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Transcript
BSC 2011 - 02
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Developmental Biology
Patterns of Inheritance
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Evolution
Ecology
Some Important Definitions
Science - the investigation of rational concepts that can be evaluated
by observations and experimentation.
Hypothesis - a proposed explanation for an observed phenomenon
Theory - a hypothesis that is consistent with all available evidence
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Outline of Lecture 1
I. THE CENTRAL DOGMA
A. DNA structure
B. DNA Replication
C. Chromosomes
1. Prokaryotic
2. Eukaryotic
D. RNA Structure
E. Transcription
1. Summary
2. Prokaryotes
3. Eukaryotes
F. Translation
1. The genetic code
2. Summary of translation
DNA structure
A linear sequence
of nucleotides
Nucleotide
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Fig 16.3
Phosphate
5-C sugar
Nitrogenous base
Thymine
Cytosine
Guanine
Adenine
Fig. 16.5
DNA Structure - the double helix
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Fig. 16.7
DNA Replication
Catalyzed by DNA-polymerase
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Fig.1.4
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Chromosome numbers in
Eukaryotes
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Chimps - 48
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Humans - 46
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Fruit fly 4
Onion - 8
Potato - ??
Chromosome numbers in
Eukaryotes
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Chimps - 48
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Humans - 46
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Fruit fly 4
Onion - 8
Potato - 48
Fig. 17.6
Transcription
Template strand - the single strand of DNA that is transcribed
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RNA polymerase - the enzyme that catalyzes the synthesis of RNA
using DNA as the template
Promoter - the segment of the DNA template strand where RNA
polymerase binds and initiates transcription
Fig. 17.6
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Fig. 17.6
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Fig. 17.6
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Fig. 17.8,17.9
RNA processing
5’ cap
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RNA splicing
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Poly-A- tail
Fig. 17.4
The Genetic Code
Codon - 3 base sequence
that codes for one amino
acid or is a signal.
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Fig. 17.13
Transfer RNA (tRNA)
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Fig. 17.12
Translation of mRNA
into protein
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Fig. 17.25
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