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Synthesis of B-homo analogues of steroid esrtogenes Drozdov Andrey [email protected] Scientific supervisor: Prof. Dr. Shavva A.G., Department of Natural Compounds Chemistry, Faculty of Chemistry, SaintPetersburg State University Estrogens play an important role in many biological processes. Because of the regulatory function estrogens play an important role in cancer development. Up to 95% of human breast cancers, at the origin, are hormone-dependent. By combination of different modifications it is possible to alter biological activity of the estrogen analogue to use it as drug [1]. Most important modifications are to reduce hormonal activity of the analogue, to reduce toxicity of its metabolites and to introduce some new biological activity, e.g. ability to inhibit estrone sulfatase [2]. B-homo analogues of steroid estrogenes (Fig. 1) are representing interesting class of estrogenes. Conformational mobility of 7-member B ring reduces hormonal activity of these analogues and may prevent formation of cancerogenic metabolites. Further modifications may make them potential anticancer agents. O O H H O O I II Fig. 1. B-homo analogues of steroid estrogenes. References 1. R. Maltais, M.R. Tremblay, L.C. Ciobanu, D. Poirier // J. Comb. Chem., v. 6, № 3, p. 443-456 (2004). 2. H. Lawrence, N. Vicker, G.M. Allan, A. Smith, M.F. Mahon, H.J. Tutill, A. Purohit, M.J. Reed, B.V.L. Potter // J. Med. Chem., 48, 2759 (2005).