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Chemotherapy of Cancer Folder Title: Chemothe Updated: April 6, 2003 (Powerpoint) ALL4656A ALL4656A ALL4656B ALL4656B ALL4656C ALL4656C ALL4656D AL465T ALL4680A ALL4689T Pitot, Table 20.1 Acquisition of New Anti-Cancer Drug, 1940 – 1990. Pitot, Figure 20.1 Needs in Cancer Chemotherapy Mechanisms of action beyond DNA synthesis and microtubule effects on mitosis Exploitation of tumor-specific cell biology Exploitation of physiology beyond cellular level Oncogene products and signal transduction Induction of apoptosis Reversal of immortalization Angiogenesis Invasion and metastasis New sources of anti-neoplastic agents Needs Cell cycle specific anti-cancer agents Pitot, Figure 20-13 Molecular Mechanisms of Resistance to Chemotherapy Pitot, Figure 20-10
