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Open Notebook Science And the Library British Columbia Library Association Open Access Conference Jean-Claude Bradley E-Learning Coordinator College of Arts and Sciences Drexel University April 19, 2007 Open and Closed Science Traditional Lab Notebook (unpublished) Traditional Journal Article Open Access Journal Article Open Notebook Science (full transparency) RESEARCH OPEN CLOSED TEACHING Traditional Paper Textbook F2F lectures Lectures Notes public Assigned problems public Archived Lectures Public and free online textbooks Agenda This session will cover the dissemination of primary scientific information via blogs, wikis and other non-traditional vehicles 1. Types of information raw experimental data (Open Notebook Science) analyzed data hypotheses “failed” experiments generalized protocols traditional article format 2. Issues Intellectual Property Referencing and claims to priority Academic Validation Peer Review – mandatory and elective 3. Opportunities Increasing productivity in terms of universally usable knowledge units Making explicit the nature and quantity of work in collaborations Using semantically rich formats and automation at zero publication cost – is this the way to the technological singularity? Where is Science headed? WE ARE HERE The Robot Scientist How will this happen? Self-organizing reduntant processes Agents can participate with zero or nearzero cost (free hosted services) Fully Open Access (Read and Write) Publication of all aspects of the scientific process: Open Source Science / Open Notebook Science How can machines know what is important? Ask the humans UsefulChem Blog What chemists think is important in 2005 Find-A-Drug Diketopiperazine Library First iteration: Solid Support Synthesis Evolves to: on pot Ugi reaction/cyclization The Molecules Blog The Experiments Blog Comments from peers The UsefulChem Wiki Telling the story of the failures Experiments moved to wiki Experiment History Experiment Edits Third Party Time-Stamp on Experiment Versions Monitoring experimental progress How are people finding our experiments? Molecules found by InChI Automation in UsefulChem CMLRSS feed on Bioclipse Open science connectivity More info on open source science here http://usefulchem.wikispaces.com The blog as an integrative tool usefulchem.blogspot.com The wiki as the laboratory notebook usefulchem.wikispaces.com/Exp049 Graphical Mining of Data with JSpecView usefulchem.wikispaces.com/Exp049 (2 min) Raw Experimental Data neurodatabase.org Selected Experiments (some failed) Orgprepdaily.wordpress.com Vendor Reliability Orgprepdaily.wordpress.com Generalized Protocols Openwetware.org Lab Notebook for intra-group communication Openwetware.org Discussing Hypotheses RRResearch.blogspot.com Writing Code for the Automation Component Also – Rich Apodaca, Christoph Steinbeck, Peter Murray-Rust