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DR. STEFANO DONADIO Fundador y Presidente KtedoGen, Italia. http://www.ktedogen.com/stefano.html Miercoles 20 de Octubre 12:00pm Sala de Seminarios 4º PISO, Edificio B There is an urgent need for new antibiotics effective against the increasing number of multidrug resistant pathogens. Natural products have represented and still represent an important source of chemical diversity. Our core technology is represented by a microbial product platform acquired from the former Biosearch Italia/Vicuron and we are thus undertaking different approaches to discover previously unreported chemical classes or significantly improved variants of existing classes. One approach is represented by data mining from a database of previously generated HTS data; the other approach consists in directly screening new actinomycete taxa. For the data mining approach, we have looked at a program aimed at identifying inhbitors of cell wall biosynthesis. From it, we have identified several novel lantibiotics from diverse actinomycete genera, revised the structure of a previously reported molecule and compared their bioactivities to those of NAI-107, produced by a Microbispora strain, the most advanced compound in this series. NAI-107 shows excellent activity against all isolates of Staphylococcus aureus, Streptococcus pneumoniae and enterococci, irrespective of their reisistance phenotype. This molecule is also efficacious in several models of experimental infections. Other lantibiotics structurally related to NAI-107 have been characterized and their properties will be presented. Concerning the second approach, in the course of an isolation program aimed at identifying actinomycetes belonging to new taxa, we isolated hundreds of different representatives of a new taxon within the suborder Thermomonosporaceae, initially denominated "alpha" and independently named Actinoallomurus. We present a phylogenetic analysis of some strains from our collection and the preliminary results from a screening program, with the first metabolites identified from the genus Actinoallomurus.