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National Institute of Integrative Medicine Newsletter February, 2007 www.niim.com.au This edition: News Snapshot – Travel Restrictions ‘Cancer and Complementary Medicine’ Prof Avni Sali and Assoc Prof Luis Vitetta Booklist: ‘Foods that fight cancer’ Richard Beliveau ‘We want real food’ Graham Harvey News The last few months have been extremely busy at the NIIM with both Professor Avni Sali and Associate Professor Luis Vitetta being invited to speak at several seminars as well as conducting various workshops. In October, Professor Sali visited Singapore where, as keynote speaker at the Singapore International Integrative Medicine Meeting, he addressed the topic of 'the overview and scope of integrative medicine in Asia-Pacific' and also offered workshops on multiple topics. Following this, back at home in Australia, he addressed the Gawler Foundation Annual Conference receiving extremely positive feedback for his lecture on Mind/Body medicine and workshop on the management of cancer. In November, Professor Sali was a lecturer at the Natural Therapies Expo where he spoke about Anti-Ageing medicine and later that month he was joined by Associate Professor Vitetta at the General Practitioners’ Conference and Exhibition in Melbourne. Associate Professor Vitetta opened the conference with a seminar on 'Nutrition and Osteoarthritis' and Professor Sali conducted a workshop on ‘Foods that accelerate ageing’. In addition to the seminars and conferences, both Professor Sali and Associate Professor Vitetta have continued writing articles in the usual publications. 2007 looks to be a busy year; already we have welcomed Stephen Bunce BBus(InfoSys) to the team, with the focus of expediting the necessary processes for offering our post-graduate courses. The various systems required to facilitate course delivery are currently being developed and with the experience brought to the team by Mr. Bunce we are hoping to have these operational and the course accreditation process completed in the near future. Please make sure to check our website for news updates as well as details about upcoming seminars and workshops. www.niim.com.au Snapshot – Travel Restrictions A recent study investigated what effect different levels of travel restrictions might have on the speed and geographical spread of an outbreak of a disease similar to severe acute respiratory syndrome (SARS). A stochastic simulation model was used, incorporating survey data of travel patterns between municipalities in Sweden collected over 3 years. The study tested scenarios of travel restrictions in which travel over distances >50 km and 20 km would be banned, taking into account different levels of compliance and found that a ban on journeys >50 km would drastically reduce the speed and geographical spread of outbreaks, even when compliance is < 100%. See the whole article: http://www.biomedcentral. com/1741-7015/4/32 2 NATIONAL INSTITUTE OF INTEGRATIVE MEDICINE – FEBRUARY 07 Cancer and Complimentary Medicine This article, written by Avni Sali and Luis Vitetta, appeared in the Journal of Complimentary Medicine. “…most cancers are difficult to treat successfully and therefore there needs to be a major effort made to prevent this disease and community education is an integral part” This editorial highlights the priority that is the prevention of cancer and the role mind-body medicine modalities and nutritional and herbal therapies can play in the management of this disease. The Cook Senate inquiry on the care of cancer patients and complementary medicine [CM] summarises the current needs. Incidence The prognosis of the majority of cancer patients has not improved over the last forty years. The incidence rates of cancer for males and females in Australia are much higher than for the UK and Canada, but slightly lower than for the US and lower than for New Zealand [NZ][1]. Australia’s mortality rates are lower than all of these countries. Australia has one of the highest rates of colorectal cancer. Breast cancer is also much higher in Australia than the average for the more developed countries of the world, but almost the same as for Canada and NZ and below that of the US. Australia’s male lung cancer incidence and mortality rates are both well below the averages for the more developed countries of the world, especially when compared with the high incidence rates in Canada, the US and most European countries. illness better significantly prognosis. Prevention of Cancer Mind-Body Medicine The lower incidence for lung cancer in Australia is almost certainly due to the major preventive programs that have been a feature in this country [1,2]. Another example of the success of preventive action is that of cervical cancer primarily as a result of the national screening program. Clearly most cancers are difficult to treat successfully and therefore there needs to be a major effort made to prevent this disease and community education is an integral part. It is known that stress reduction improves immunity and decreases stress hormones such as cortisol, insulin, growth hormone and prolactin which can stimulate growth [3-5]. It is now generally accepted that psychosocial interventions have beneficial effects on psychological health although there is considerable controversy surrounding the effects of such interventions on physical health and survival for cancer. A review of the published studies shows that five of ten studies report that psychotherapy prolongs survival. Whereas three trials demonstrated psychological benefit and no survival benefit [4]. It is likely that the quality of the psychosocial support determines whether there is survival benefit. Those who are best placed to carry out education about prevention of this disease are general practitioners [GP’s] who have frequent contact with the community [2]. Other health professionals e.g. naturopaths, pharmacists and others are also well placed to carry out education about cancer prevention. GP’s who work in integrative medicine are interested in why a person has developed cancer but this is not the case in mainstream medicine where the emphasis is on diagnosis and treatment. In the care of the cancer patient the very least that should be done is to make the patient as healthy as possible as this in itself is very likely to help the patient cope with their and may improve Nutritional and Supplements. Herbal Epidemiology provides compelling evidence that many cancers may be avoidable. In an epidemiological study of 24 European countries a direct correlation was found between the consumption of animal fat and colorectal plus breast cancer with an inverse relationship with fish oil consumption [6,7]. NATIONAL INSTITUTE OF INTEGRATIVE MEDICINE – FEBRUARY 07 3 Cancer and Comp. Medicine Cont… There is ongoing controversy over the role of dietary fat and cancer [8]. It is our opinion that epidemiological studies that compare people in different countries tend to yield the most reliable information provided differences in human behaviour are taken into consideration. Many of the studies have not differentiated between the different types of fats consumed [8]. Fruit and vegetables have generally been shown to be protective against cancer and it is possible that nutrients such as vitamin C and E plus other plant phytochemicals such as isoflavones play an important part [9,10]. A healthy diet for a cancer patient is of key importance not only to improve general health but as there is increasing evidence showing that certain nutrients can be cytotoxic to cancer cells whereas other nutrients can promote cancer growth. For example substances in cruciferous vegetables can be cytotoxic to cancer cells in vitro and soy can influence growth of prostate cancer [10]. Selenium and vitamin D also inhibit prostate cancer cells [11]. Although there is a dearth of clinical studies investigating the role of nutrient supplements, an example is the use of a combination of a mega dose of nutrients to reduce the recurrence of bladder cancer by approximately half [12,13]. Prasad and others have demonstrated in in vitro experiments and preliminary human studies that high doses of multiple antioxidants enhance the efficacy of chemotherapy on cancer cells [14]. It is essential that these studies are further tested in humans. A Chinese herbal combination initially called PC SPES and more recently prostasol has been found to cause regression of prostate cancer in humans in several studies but there has been very little interest on its role [15]. Senate Inquiry Senator Peter Cook, a Western Australian Senator who died last year was responsible for initiating one of the most important Senate inquiries to do with health in this country [16]. It is significant that there was all party support for this Senate inquiry. Senator Cook had developed metastatic melanoma and was very disappointed with the poor care he received especially as a result of the lack of integration in the management of his cancer. With the Gawler Foundation, one of us (AS) was fortunate to provide input to this Senate inquiry and the receptive response by the Senators was most auspicious. The Senate report has been passed by the Senate and is currently being processed by Government. Key aspects of the report included that there should be dedicated research funding established with appropriate CM representation to assess research applications, Cancer Australia was to provide information on CM to cancer patients and health professionals, referral networks to be enhanced and that an integrative approach be encouraged through expansion of the MBS. A diagnosis of cancer is enough to shatter most people. It is essential that those involved with cancer patients maintain a sense of humanity and sensitivity as human beings and also remain open to the possibilities that could improve the well being and survival of their chronically ill patients. It is clear that while survival from cancer is generally poor, the emphasis must be on prevention of this family of diseases. References 1. Australian Bureau of Statistics. National Health Survey: Summary of Results - Australia 2004 - 2005 ; <http://www.abs.gov.au/a usstats/[email protected]/> 2. Sali A. JCM 2004; 2:58-65 3. Fawzy F, et al. Malignant melanoma. Effects of an early structured psychiatric intervention, coping, and affective state on recurrence and survival 6 years later. Arch Gen Psychiatry. 1993; 50(9):681-9 Continues on next page… Professor Avni Sali MBBS, PhD, FRACS, FACS, FACNEM is founding head and director of the National Institute of Integrative Medicine (NIIM), president of the Gawler Foundation and Vice-President of the Australian Integrative Medicine Association (AIMA). Assoc Professor Luis Vitetta BSc(Hons), PhD, GradDip IntegrMed, GradDip NutrEnvironMed is deputy director of the National Institute of Integrative Medicine (NIIM) and Senior Research Fellow, Centre for Molecular Biology and Medicine. 4 NATIONAL INSTITUTE OF INTEGRATIVE MEDICINE – FEBRUARY 07 Cancer and Comp. Medicine Cont… 4. Reavley N, Vitetta L, Cortizo F, Sali A. JAIMA 2004. 5. Stolzenberg-Solomon RZ, et al. Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA. 2005; 294(22):2872-8. ‘Foods that Fight Cancer’ Richard Beliveau Ph.D, Denis Gingras Ph.D Publisher: McClelland & Stewart (2006) 216 pages ISBN-10: 0771011350 ISBN-13: 978-0771011351 6. Terry PD, et al. Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence. Am J Clin Nutr. 2003; 77(3):532-43. Review. 7. Caygill CP et al. Fat, fish, fish oil and cancer. Br J Cancer. 1996; 74(1):159-64. 8. Prentice RL, et al. [The Women’s Health Initiative]. Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized. Controlled Dietary Modification Trial. JAMA. 2006; 295(6):629-42. 9. Pham PTK et al, In Complementary and Alternative Medicine, an evidence-based approach, St. Louis, Mosby, 2003; 93152. 10. Tiwari RK, etal. Selective responsiveness of human breast cancer cells to indole-3-carbinol, a chemopreventive agent. JNCI 1994; 86(2):126-31. 11. Corcoran NM et al. Inorganic selenium retards progression of experimental hormone refractory prostate cancer. J Urol. 2004; 171(2 Pt 1):907-10. 12. De Luca HF et al, In An Evidence-Based-Approach to Vitamins and Minerals , New York, Thieme, 2003:73-81 13, Lamm DL et al , Megadose vitamins in bladder cancer: a doubleblind clinical trial. J Urol. 1994; 151(1):21-6. 14. Prasad K et al, Complementary Oncology, New York, Thieme, 2005:151170 15. Pirani JF. The effects of phytotherapeutic agents on prostate cancer: an overview of recent clinical trials of PC SPES. Urology. 2001; 58(2 Suppl 1):36-8. Review. 16. Commonwealth of Australia. Inquiry into services and treatment options for persons with cancer, 2006. <http://www.aph.gov.au/Sen ate/committee/clac_ctte/ca ncer/index.htm> Recommended Books ‘Foods that Fight Cancer’, Richard Beliveau Ph.D, Denis Gingras Ph.D “Over 138,000 Frenchlanguage copies sold! ‘We Want Real Food’ Graham Harvey Publisher: Constable & Robinson (2006) 256 pages ISBN-10: 1845292677 ISBN-13: 978-1845292676 Within this book is the perfect recipe for success: An author who is one of the world’s foremost experts in the groundbreaking area of how food chemistry can fight cancer. A highly accessible and practical text. A beautifully designed package accompanied by full-colour illustrations. According to the Canadian Cancer Society, an estimated 149,000 new cases of cancer occurred in Canada in 2005. While this statistic is alarming, current research is showing convincingly that elements in particular foods may significantly reduce the risk of cancer in healthy individuals and slow its progress in those already suffering from the disease. We can help ourselves and our families through healthy eating. But the information coming through the popular media is confusing and often hard to understand. Just what should we be eating and in what combinations? Do all cancer-fighting foods work the same way? Do they all fight all kinds of cancers? In Foods That Fight Cancer, leading biochemist Richard Béliveau teams up with Denis Gingras to describe the science of food and which properties of particular foods are the active cancer-fighting elements. They deftly explain how different foods work to protect the body against different cancers and show which foods will be most effective. By understanding the science behind these therapeutic benefits, we come to realize not only why it is so critical to add these foods to our diet, but how easily it can be done.” NATIONAL INSTITUTE OF INTEGRATIVE MEDICINE – FEBRUARY 07 NATIONAL INSTITUTE OF INTEGRAIVE MEDICINE Recommended Books E-mail [email protected] ‘We Want Real Food’ Graham Harvey Jamie Oliver's School Dinners, Rick Stein's Food Heroes, Hugh Fearnley-Whittingstall's field-to-table fare at River Cottage - the message is all around us that good food, nutrition and health go hand in hand, and we need to eat more fresh, unprocessed foods. Graham Harvey won the BP Natural World Book Prize for his book, The Killing of the Countryside in 1997. Now he tells the story of how the food we buy in supermarkets was grown, why it is lacking in nutrients and what we can do about it - by mounting a campaign for real food. He tells the story of industrial farming's huge growth in the second half of the 20th century and shows how the widespread use of nitrate fertilisers has depleted the soil of minerals. Even organic foods can be tasteless and lacking in vitamins and, particularly, in the essential trace elements that keep us healthy. The lack of minerals in modern foods is a contributing factor to the chronic diseases of industrial societies. He argues eloquently and clearly that the solution is an increase in the nutrient-rich foods our bodies need. The campaign for real food begins with us, whether we shop at farmers' markets, organic suppliers or at supermarkets. About Our Organization The National Institute of Integrative Medicine (NIIM) formed as a natural development from the Graduate School of Integrative Medicine (GSIM), formerly part of Swinburne University. The NATIONAL INSTITUTE OF INTEGRATIVE MEDICINE [email protected] Visit our website at: www.niim.com.au GSIM was founded by Professor Avni Sali in 1997 as a reflection of the growing number of general practitioners who were combining complementary medicine and therapies with conventional medical 5 practice. The NIIM is currently in the process of establishing a unique wellness clinic as well as development to a position where it can begin to deliver courses and conduct research.