Download Path Seminar_Amarni_Luke

Department of Pathology
2016 Seminar Programme Presents:
Amarni Thomas and Luke Henderson
Friday 5th August 2016 D’Ath Lecture Theatre, Hercus Building
Amarni Thomas: Transcrip/onal regula/on of the Runx1 gene
The developmental transcription factor RUNX1/AML1 is a well-known leukaemia-associated
gene. Runx1 is an important regulator of definitive haematopoiesis in vertebrates; it is crucial for
early myeloid differentiation, and plays a vital role in adult haematopoiesis. Although RUNX1 is
frequently translocated or mutated in AML, 25 % of patients do not have a disruption in known
AML genes. We hypothesise that in cases where no mutation or translocation is found in the
coding sequence of RUNX1, there may be mutations in non-coding regulatory sequences that
affect gene expression. This PhD project aims to provide insight into the elaborate orchestration
of Runx1 regulation, as well as reveal the genetic roles of RUNX1 and cis-regulatory elements in
AML development. Luke Henderson: Melanoma and the regula/on of the p53 pathway" The developmental transcription factor RUNX1/AML1 is a well-known leukaemia-associated
gene. Runx1 is an important regulator of definitive haematopoiesis in vertebrates; it is crucial for
early myeloid differentiation, and plays a vital role in adult haematopoiesis. Although RUNX1 is
frequently translocated or mutated in AML, 25 % of patients do not have a disruption in known
AML genes. We hypothesise that in cases where no mutation or translocation is found in the
coding sequence of RUNX1, there may be mutations in non-coding regulatory sequences that
affect gene expression. This PhD project aims to provide insight into the elaborate orchestration
of Runx1 regulation, as well as reveal the genetic roles of RUNX1 and cis-regulatory elements in
AML development. Proudly sponsored by