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EURO DIAGNOSTICA
PRODUCT CATALOG
RADIOIMMUNOASSAY (RIA)
Copyright: © 2014, Euro Diagnostica AB
Version: 2014-06
Graphic design: Oddville AB
Printed by: Bildcenter i Lund AB
Radioimmunoassay Catalog
Euro Diagnostica
We are proud to introduce the 2013/2014
RIA Catalog
Euro Diagnostica is an international diagnostic solutions provider in autoimmunity testing with
a long history and commitment to quality. The company celebrates 20 years this year and was
created following a merger between Ferring Diagnostica, Balticor Diagnostica, Euro Diagnostics
and Medscand Diagnostics (MILAB). In 2004, Euro Diagnostica expanded its services by acquiring Wieslab AB, Sweden, a leading autoimmunity testing laboratory.
From its facilities in Malmö, Sweden, Euro Diagnostica develops, manufactures and markets an
extensive product range of the highest possible quality in over 100 countries. Our complete diagnostic kits and reagents are used daily in medical assessments both manually and on the majority
of instrument platforms available worldwide. Our tests are developed for clinical auto­immunology,
microbiology and immunochemistry. Thanks to the long experience and continuous development
of our personnel and production processes, Euro Diagnostica offers top quality cost-effective customized coating services. Our Laboratory Testing Unit, Wieslab, offers clinical testing and disease
assessment within autoimmunity by qualified diagnostic specialists every day of the year. Wieslab
Laboratory Services offers a comprehensive range of individual and panel tests, and ensures
accurate and fast results. Testing is available for most autoimmune diseases.
In this catalog our radioimmunoassay (RIA) kits are presented. For a complete overview of our
product portfolio please visit our website (www.eurodiagnostica.com).
Euro Diagnostica RIA kits
Name
Page
Background RIA - Radioimmunoassay
4
Principle of the RIA technology
5
Angiotensin II EURIA
6
ANP EURIA
6
CCK EURIA
7
Chromogranin A EURIA
8
Chromogranin B EURIA
8
Beta-Endorphin EURIA
9
Endothelin EURIA
9
Gastrin EURIA
10
Glucagon EURIA
10
Alpha-MSH EURIA
11
NPY EURIA
11
PP EURIA
12
Somatostatin EURIA
12
Vasopressin EURIA
13
VIP EURIA
13
Availability and product claims may differ from country to country based on regulations and product approvals.
Please contact your local representative for further details.
RIA CATALOG
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RADIOIMMUNOASSAY (RIA)
Radioimmunoassay (RIA)
Technology
Background RIA - Radioimmunoassay
The radioimmunoassay (RIA) technology was developed during the late 1950s by Berson
and Yalow. Their work resulted in the classical paper on measurement of insulin concentrations in human plasma1. For this work on insulin, Rosalyn Yalow received the 1977
Nobel Prize in Medicine. The development of the RIA technique eventually revolutionized
research and clinical practice in many areas, in particular endocrinology. Due to the superior sensitivity of RIA, the technique continues to be widely used for accurate determination of biological components in low concentrations such as hormones. The high sensitivity allows for accurate determinations in the pmol/L range.
Technology
The rationale behind the RIA technology is fascinating in its simplicity and elegance, and
based on the principle illustrated in figure 1.
An unknown quantity of antigen in the test sample competes with a fixed concentration
of radio­labeled antigen in binding to a fixed amount of specific antibody.
Known concentrations of unlabeled antigen are included in the assay to construct a calibration
curve from which the concentration of unknown antigen in the test samples can be calculated.
Euro Diagnostica RIA Portfolio
Euro Diagnostica offers a portfolio of in-house developed RIA kits presented on the following pages. All kits are manufactured in our own production facilities. Focus areas of our RIA
products are:
•
•
•
•
Tumor markers
Endocrine markers
Metabolic markers
Vasoregulation
Our RIA portfolio was introduced more than 20 years ago and has continuously been expanded
and improved since then. Over the years the products have been appreciated by customers,
not only for their simplicity and excellent performance, but also for practical characteristics as
up to 4 years shelf life for some non-radioactive key components. This in turn results in stable
and repeatable assays.
The specification of several of our RIA kits regarding cross-reactivity and sensitivity are superior to other technologies, allowing for accurate and specific determination of some peptide
hormones present at very low concentrations.
Peptides labeling services
In addition to RIA kits Euro Diagnostica also offers peptide labeling services. During the
years of development and manufacturing of RIA kits, Euro Diagnostica has optimized the
production processes resulting in an efficient and flexible production fulfilling all applicable
quality standards.
Please contact us for prices and further discussions.
1) Yalow, RS, Berson, SA (1960). Immunoassay of endogenous plasma insulin in man.
4
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RIA catalog
J Clin Invest 39 (7): 1157–75.
Radioimmunoassay (RIA)
Technology
Principle of the RIA-technology
After mixing
and incubation
Start
Zero-standard
No Ag added
Bound* = 6
Free *= 0
I-(Labeled antigen) 125I-Ag (Fixed concentration)
Antigen Ag (Unknown concentration in test sample)
Antibody (Fixed amount)
125
*125I-Ag
Low concentration of
Ag=6
Bound* = 3
Free *= 3
Ag=12
Bound* = 2
Free *= 4
unknown antigen
High concentration of
% binding
unknown antigen
Figure 1a. RIA is a competitive assay where a fixed and
known amount of 125I-labeled antigen is used to calculate
the unknown levels of antigen (unlabeled) in the test
sample. The labeled and unlabeled antigens will compete
in binding to fixed amount of antibodies to form antigenantibody complexes. These can then be separated from
the unbound antigens and the radioactivity is measured.
Higher levels of antigen in the test sample will result in
lower signal as the unlabeled antigens will outcompete
the labeled.
ratio in
“unknown”
antigen in
“unknown”
Figure 1b. Schematic graph of a RIA standard curve.
This is prepared from known levels of antigen and used to
calculate the amount of antigen in test samples.
Unlabeled antigen (conc.)
RIA CATALOG
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RADIOIMMUNOASSAY (RIA)
Radioimmunoassay (RIA)
Products
Angiotensin II EURIA
Angiotensin II is a biologically active key compound of the reninangiotensin system. The octapeptide angiotensin II is the strongest
physiological vasoconstrictor known.
Euro Diagnostica angiotensin II kit contains reagents and instructions for
measuring angiotensin II in plasma. After the plasma samples, angiotensin II is assayed by a competitive radioimmunoassay. The assay is specific
and the cross-reactivity with Angiotensin I is very low (<0.1%). Sensitivity
determined as 3 standard deviations change from zero calibrator is
2.0 pmol/L.
Code
Name
Tests
RB 320
EURIA Angiotensin II
RIA (100 tubes)
RB 320 RUO
EURIA Angiotensin II
RIA (100 tubes)
1
2
1)
CE marked for IVD use. Not available in the US. 2) For research use only. Please contact
your local representative for availability in your country.
ANP EURIA
It has been shown that alpha-ANP causes diuretic and natriuretic
activities and relaxes smooth muscle. These effects are thought to be
mediated by circulation in peripheral blood. EURIA-ANP is a simple,
sensitive and reliable radioimmunoassay for ANP in human plasma.
Euro Diagnostica ANP kit contains reagents and instructions for quantitative measurement in plasma samples. After extraction, concentrations
are measured by non-equilibrium radioimmunoassay with delayed
addition of the iodinated tracer. The determined concentration of ANP is
expressed in picograms/mL (pg/mL). The sensitivity of the assay, judged
as 3 SD change from zero calibrator is 3.5 pg/mL.
Code
BANI RUO
1
Name
Tests
EURIA ANP
RIA (100 tubes)
For research use only.
Please contact your local representative for availability in your country.
1)
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RIA catalog
CCK EURIA
Cholecystokinin (CCK) is one of the classical gut hormones. It is believed to be a major regulator of gall bladder contraction and pancreatic enzyme secretion. CCK occurs in many different molecular forms.
The intended use of these reagents is for determination of CCK in pla­
sma. CCK is extracted from plasma. The C-terminal sulphation and the
C-terminal amidation are important for the biological activity of CCK. CCK
shares an identical sequence with gastrin in the five C-terminal amino acids, which requires an antiserum with very low cross-reactivity to gastrin.
Plasma concentrations of CCK are very low, which makes it necessary to
have a highly sensitive assay system. EURIA CCK radioimmunoassay is
based on an antiserum specific for the sulphated form of CCK, with very
low cross-reactivity to gastrin-17, sulphated gastrin. The assay system
has been optimized to a very high sensitivity of 0.3 pmol/L.
Code
Name
Tests
RB 302
EURIA CCK
RIA (100 tubes)
RB 302 RUO2
EURIA CCK
RIA (100 tubes)
1
Specificity
The following cross-reactions have been found:
Peptide
Cross-reaction
Cholecystokinin 26-33, sulphate
100.0%
Cholecystokinin-33, sulphate
134.0%
Cholecystokinin 26-33, non-sulphated
< 0.01%
Cholecystokinin 30-33
< 0.01%
Gastrin-17, sulphate
0.5%
Gastrin-17, non-sulphated
< 0.01%
1)
CE marked for IVD use. Not available in the US. 2) For research use only. Please contact
your local representative for availability in your country.
RIA CATALOG
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RADIOIMMUNOASSAY (RIA)
Radioimmunoassay (RIA)
Products
Chromogranin A EURIA
Tumours of neuroendocrine origin such as carcinoids usually present
with increased levels of chromogranin A in serum and plasma.
Neuroendocrine tumours are derived from the neuroendocrine cells and
typically include carcinoid tumours, pheochromocytomas, neuroblastomas, small cell lung cancers, hyperparathyroid adenomas, pituitary
tumours, prostate cancers and pancreatic islet tumours, including MEN1
and MEN2 syndromes. The present chromogranin A RIA is a competitive method based on polyclonal rabbit antibodies. The antibodies were
raised against a purified fragment containing amino acid sequence
116-439 of the chromogranin A molecule. The sensitivity of the assay,
judged as 2 SD change from zero calibrator, is 0.035 nmol/L. The assay
kit includes two controls (high and low).
Code
Name
Tests
RB 3211
EURIA Chromogranin A
RIA (100 tubes)
RB 321 RUO2
EURIA Chromogranin A
RIA (100 tubes)
1)
CE marked for IVD use. Not available in the US. 2) For research use only. Please contact
your local representative for availability in your country.
Chromogranin B EURIA
Chromogranins are soluble secretory proteins which are stored in
the majority of different neuroendocrine cells. Increased levels in
the circulation are often seen in conjunction with various neuro­
endocrine tumours.
However, chromogranin A levels are often elevated in response to de­
creased renal function, atrophic gastritis and treatment with proton
pump inhibitors. Chromogranin B levels are not affected by either proton
pump inhibitor treatment or decreased renal function and have been
shown to have similar use as chromogranin A. With its lower sensitivity
but very high specificity, chromgranin B measurements can serve as a
valuable complement to chromogranin A. EURIA Chromogranin B kit is a
competitive radioimunoassay (RIA) for determination of chromogranin
B in human plasma and serum. The antibodies were raised against a
synthetic peptide containing amino acid sequence 439-451 in the
chromogranin B molecule.
The sensitivity of the assay, judged as 2 SD change from zero calibrator,
is 0.19 nmol/L.
Code
RB 322
1
RB 322 RUO
2
Name
Tests
EURIA Chromogranin B
RIA (100 tubes)
EURIA Chromogranin B
RIA (100 tubes)
1)
CE marked for IVD use. Not available in the US. 2) For research use only. Please contact
your local representative for availability in your country.
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RIA catalog
Beta-Endorphin EURIA
ß-endorphin is found in neurons of the hypothalamus, as well as the
pituitary gland. The behavioural effects of ß-endorphin are exerted
by its actions in the brain and spinal cord, and it is presumed that the
hypothalamic neurons are the major source of ß-endorphin at these
sites. In situations where the level of ACTH is increased (e.g., Cushing’s Syndrome), the level of endorphins also increases.
ß-endorphin in sample (plasma, cerebrospinal fluid or tissue) is extracted.
The extracts are analysed by a competitive radioimmunoassay using antibodies against synthetic human ß-endorphin. Sensitivity calculated from
a decrease in binding of 2 SD in the zero standard is 3 pmol/L.
Code
RB 301 RUO
1
Name
Tests
EURIA Beta-Endorphin
RIA (100 tubes)
For research use only.
Please contact your local representative for availability in your country.
1)
Endothelin EURIA
Endothelin is synthetized in and released from endothelial cells.
Endothelin occurs in three different molecular forms: Endothelin
1, 2 and 3. Endothelin 1 is a potent vasoconstrictor peptide. Endo­
thelin occurs in the circulation in very low concentrations and may be
an important factor in the regulation of local blood circulation, blood
pressure and contractility of the heart.
Endothelin is extracted from plasma. The extracts are assayed by a competitive radioimmunoassay using a rabbit antiserum raised against an
endothelin-1 albumin con­jugate. The antiserum used in this assay crossreacts with endothelin-1 (100%), endothelin-2 (48%) and endothelin-3
(109%). The lowest de­tectable concentration is 4 pmol/L corresponding
to 0.4 pmol/L in the sample.
Code
Name
Tests
RB 304 RUO1
EURIA Endothelin
RIA (100 tubes)
For research use only.
Please contact your local representative for availability in your country.
1)
RIA CATALOG
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RADIOIMMUNOASSAY (RIA)
Radioimmunoassay (RIA)
Products
Gastrin EURIA
Gastrin is involved in a number of physiological processes in the GI
tract such as stimulating secretion of gastric acid (HCl) by the parietal
cells of the stomach and inducing pancreatic secretions and gall­
bladder emptying.
Determining gastrin is useful when diagnosing gastrin-producing
tumours and achylia with or without pernicious anemia. In ZollingerEllison syndrome, gastrin is produced at excessive levels, often by
a gastrinoma.
Treatment with powerful anti-secretagogues may cause a rise in the serum gastrin concentration, and measurement of serum gastrin can thus
be used to monitor the treatment efficacy. Gastrin occurs in the circulation in several different forms, among those gastrin-34 and gastrin-17,
sulphated and non-sulphated. The five C-terminal amino acids of gastrin
and cholecystokinin are identical, which explains their overlapping biological effects. The antiserum used in this assay completely cross-reacts
with gastrin-34 and the sulphated forms of gastrin-17 and gastrin-34,
but much less with CCK-8.
Code
MD 302
1
MD 302 RUO
2
Name
Tests
EURIA Gastrin
RIA (100 tubes)
EURIA Gastrin
RIA (100 tubes)
Specificity
The following cross-reactions have been found:
Compound
Cross-reaction
Gastrin-17
100.0%
Gastrin-17, sulphated
83%
Gastrin-34
61%
CCK-8
36%
Gastrin 1-14
< 0.1%
Gastric releasing peptide
< 0.01%
Vascoactive intestinal peptide
< 0.01%
Motilin
< 0.01%
Glucagon
< 0.01%
Somatostatin 14
< 0.01%
C-peptide
< 0.01%
1)
CE marked for IVD use. Available in the US. 2) For research use only. Please contact your
local representative for availability in your country.
Glucagon EURIA
Glucagon is involved in carbohydrate, fat and protein metabolism.
Basal amounts of glucagon are essential for the maintenance of
normoglycemia and one physiological role for glucagon is to
prevent hypoglycemia.
Since glucagon in diabetics has been found elevated absolutely or relatively to insulin, it has been proposed that glucagon contributes essentially to the development of the hyperglycemia and keto acidosis found
in diabetes. Elevated levels of glucagon in plasma are found in patients
with A-cell tumors. (Glucagon is a 29-amino acid straight-chain peptide
produced in the pancreatic alpha cells.) EURIA radioimmuno assay is
specific for pancreatic glucagon with no cross-reactivity with gut GLI
(Glucagon-Like-Immunoreactivity). The sensitivity of the assay, judged as
2 SD change from zero calibrator, is 3 pmol/L.
EURIA Glucagon correlates with WHO 69/164 standard.
Code
RB 310
1
RB 310 RUO
1)
2)
10
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2
Name
Tests
EURIA Glucagon
RIA (100 tubes)
EURIA Glucagon
RIA (100 tubes)
CE marked for IVD use. Available in the Us and Japan.
For research use only. Please contact your local representative for availability in your country.
RIA catalog
Specificity
The following cross-reactions have been found:
Peptide
Cross-reaction
Glucagon, pancreatic, human
100.0%
Gut GLI
< 0.1%
Secretin
< 0.02%
Cholecystokinin -39
< 0.02%
Vasoactive intestinal peptide
< 0.02%
Gastric inhibitory peptide
< 0.02%
Alpha-MSH EURIA
Alpha-Melanocyte Stimulating Hormone (Alpha-MSH) is a potent
modulator of fever and inflammation. The average plasma AlphaMSH level has been found higher in subjects with AIDS than in
control subjects.
Alpha-MSH is derived from pro-opiomelanocortin, a precursor protein
that contains, within its structure, the sequences of other melanotropic
peptides. Alpha-MSH is a 13-amino acid peptide with identical sequence
to adrenocorticotropic hormone (ACTH 1-13). The intended use of the
EURIA radioimmuno assay kit is the determination of Alpha-MSH in
human plasma or cerebrospinal fluid. The antiserum used in this kit is
directed to the amidated C-terminal part of the Alpha-MSH molecule and
shows no cross-reactivity to ACTH (Adreno-Corticotropic-Hormone). Sensitivity calculated from a decrease in binding of 2 SD in the zero standard
is 3 pmol/L.
Code
RB 303 RUO
1
Name
Tests
EURIA Alpha-MSH
RIA (100 tubes)
For research use only.
Please contact your local representative for availability in your country.
1)
NPY EURIA
Neuropeptide Y (NPY) is a 36-amino acid peptide hormone found
in the brain and autonomic nervous system. The hormone has been
shown to be involved in several physiological/clinical processes
including food intake, obesity, and anorexia nervosa.
Increased serum/plasma concentrations of NPY have been found in pat­
ients with neuroblastoma and phaeochromocytoma. Increased serum/
plasma concentrations of NPY have also been found in pediatric B-cell
precursor leukemia. The intended use of this EURIA kit is determination
of NPY in human serum/plasma by direct assay without extraction. The
antiserum used is very specific for NPY with no cross-reactivity with
either pancreatic polypeptide (PP) or peptide YY (PYY). Sensitivity calculated from a decrease in binding of 2 SD in the zero standard is 3 pmol/L.
Code
RB 317
1
RB 317 RUO
2
Name
Tests
EURIA NPY
RIA (100 tubes)
EURIA NPY
RIA (100 tubes)
1)
CE marked for IVD use. Not available in the US. 2) For research use only. Please contact
your local representative for availability in your country.
RIA CATALOG
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RADIOIMMUNOASSAY (RIA)
Radioimmunoassay (RIA)
Products
PP EURIA
Pancreatic polypeptide (PP) is secreted by the F-cells of the islets
of Langerhans in the pancreas. PP is localized almost entirely in the
pancreas , although detectable levels throughout gastrointestinal tract
have been reported.
The secretion of PP is stimulated by intake of food, especially protein
and fat. Its function is to self-regulate pancreatic secretion activities. PP
also effects hepatic glycogen levels and gastrointestinal secretions. It
is also produced by endocrine-active tumours in the pancreas and the
gastrointestinal tract. These tumours often produce several peptide hormones in the combinations PP-VIP, PP-glucagon or PP-gastrin. Tumours
with only PP-secretion have been reported. These tumours may occur at
the WDHA or Verner- Morrison syndrome.
EURIA PP kit is intended for determining PP in human serum. Serum PP
is assayed without extraction by a competitive radio­immunoassay using
a rabbit antiserum raised against bovine PP. The assay is specific for PP
with very low cross-reactivity to a number of other functionally-related
peptide hormones. Sensitivity calculated from a decrease in binding of
2 SD in the zero standard is 3 pmol/L.
Code
Name
Tests
RB 3161
EURIA PP
RIA (100 tubes)
RB 316 RUO2
EURIA PP
RIA (100 tubes)
1)
CE marked for IVD use. Not available in the US. 2) For research use only. Please contact
your local representative for availability in your country.
Somatostatin EURIA
Somatostatin is a cyclic peptide hormone secreted in several locations
of the digestive system such as the stomach, intestine and delta cells
of the pancreas. It is also secreted in the brain (e.g. hypothalamus).
Functionally, somatostatin is an inhibitor hormone, inhibiting release of
other hormones such as growth hormone, TSH, glucagon and gastrin.
Somatostatin in plasma is extracted. The extracts are analysed by a
competitive radioimmunoassay using an antiserum to synthetic cyclic
somatostatin 14. The sensitivity calculated from a decrease in binding
of 2 SD in the zero standard is 6 pmol/L.
Code
Name
Tests
RB 306 RUO2
EURIA Somatostatin
RIA (100 tubes)
For research use only.
Please contact your local representative for availability in your country.
1)
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RIA catalog
Vasopressin EURIA
One of the most important roles of vasopressin or antidiuretic hormone (ADH) is to regulate the body’s retention of water. In addition,
vasopressin has been implicated in a variety of physiological functions and has clinical applications in diabetes, hyponatraemia, and
hypertension studies.
Vasopressin, or Antidiuretic Hormone (ADH), is a cyclic nanopeptide with
a structure very similar to that of oxytocin, differing in only two amino acids. Euro Diagnostica vasopressin kit contains reagents and instructions
for the quantitative measurement of vasopressin in plasma or urine. After
solid-phase extraction (SPE) or ethanol extraction, plasma vasopressin
concentrations are measured by radioimmunoassay (RIA). Urine vasopressin concentrations can be measured directly. The assay is specific
for vasopressin with no cross-reactivity to oxytocin. It has been calibrated
against WHO standard 77/501. Sensitivity calculated from a decrease in
binding of 3 SD in the zero standard is 0.5 pmol/L
Code
RB 319
1
RB 319 RUO
1
Name
Tests
EURIA Vasopressin
RIA (100 tubes)
EURIA Vasopressin
RIA (100 tubes)
1)
CE marked for IVD use. Not available in the US. 2) For research use only. Please contact
your local representative for availability in your country.
VIP EURIA
Specificity
The following cross-reactions have been found:
Vasoactive intestinal peptide (VIP) is produced in many tissues
including the gut, pancreas and hypothalamus. It is a linear poly­
peptide structurally related to secretin and other members of the
secretin family.
VIP is believed to play crucial roles in the regulation of intestinal motility
and intestinal epithelial ion and water transport. Increased plasma immunoreactive VIP concentrations have been reported in patients with WDHA
syndrome (water, diarrhea, hypokalemia and achlor hydria). Increased
plasma levels have also been reported in patients with cirrhosis. EURIA
VIP kit is used to determine VIP in human plasma by a competitive radioimmunoassay without extraction. The assay is specific for VIP with very
low cross-reactivity to other members of the secretin family. Its sensitivity calculated from a decrease in binding of 2 SD in the zero standard
is 3 pmol/L.
Code
Name
Tests
RB 3111
EURIA VIP
RIA (100 tubes)
EURIA VIP
RIA (100 tubes)
RB 311 RUO
2
Parameter
Cross-reaction
VIP 1-28 (whole sequence)
100%
VIP 1-6
< 2.5%
VIP 1-18
< 2.5%
VIP 1-22
< 2.5%
VIP 11-28
83.3%
VIP 7-28
90.9%
VIP 18-28
71.4%
Secretin, porcine
< 0.01%
Gastric inhibitory peptide, porcine
< 0.01%
Pancreatic gluacon, porcine
< 0.01%
Enteroglucagon, porcine
< 0.01%
Pancreatic polypeptide, human
< 0.01%
Substance P
< 0.01%
Somatostatine, ovine
< 0.01%
1)
CE marked for IVD use. Not available in the US. 2) For research use only. Please contact
your local representative for availability in your country.
RIA CATALOG
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TECHNICAL / PRODUCT OVERVIEW
Product overview
Alphabetical order
Technical / Product overview
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EURIA Product
Product code
Antigen(s)/Material
Angiotensin II
RB 320
Synthetic peptide, polyclonal antiserum
Angiotensin II
RB 320 RUO
Synthetic peptide, polyclonal antiserum
ANP
BANI RUO
Synthetic peptide, polyclonal antiserum
CCK
RB 302
Synthetic sulphated peptide (CCK-8), polyclonal antiserum
CCK
RB 302 RUO
Synthetic sulphated peptide (CCK-8), polyclonal antiserum
Chromogranin A
RB 321
Purified human chromogranin A fragment
Chromogranin A
RB 321 RUO
Purified human chromogranin A fragment
Chromogranin B
RB 322
Synthetic peptide
Chromogranin B
RB 322 RUO
Synthetic peptide
Beta-Endorphin
RB 301 RUO
Synthetic peptide, polyclonal antiserum
Endothelin
RB 304 RUO
Synthetic peptide, polyclonal antiserum
Gastrin
MD 302
Synthetic sulphated peptide, polyclonal antiserum
Gastrin
MD 302 RUO
Synthetic sulphated peptide, polyclonal antiserum
Glucagon
RB 310
Synthetic peptide, polyclonal antiserum
Glucagon
RB 310 RUO
Synthetic peptide, polyclonal antiserum
Alpha-MSH
RB 303 RUO
Synthetic peptide, polyclonal antiserum
NPY (neuropeptide Y)
RB 317
Synthetic peptide, polyclonal antiserum
NPY (neuropeptide Y)
RB 317 RUO
Synthetic peptide, polyclonal antiserum
PP (pancreatic polypeptide)
RB 316
Synthetic peptide, polyclonal antiserum
PP (pancreatic polypeptide)
RB 316 RUO
Synthetic peptide, polyclonal antiserum
Somatostatin
RB 306 RUO
Synthetic peptide, polyclonal antiserum
Vasopressin
RB 319
Synthetic peptide, polyclonal antiserum
Vasopressin
RB 319 RUO
Synthetic peptide, polyclonal antiserum
VIP (vasointestinal peptide)
RB 311
Synthetic peptide, polyclonal antiserum
VIP (vasointestinal peptide)
RB 311 RUO
Synthetic peptide, polyclonal antiserum
RIA catalog
Market Authorization
Standards,
Controls
Specimen,
Sample volume
Incubation times
(min)
IVD use in Europe (EEA)
7, low C, high C
Plasma, extraction
24 h
RUO, worldwide
7, low C, high C
Plasma, extraction
24 h
RUO, worldwide
9, low C, high C
Plasma, extraction
48 h
IVD use in Europe (EEA)
High C, low C
Plasma, extraction
6 days
RUO, worldwide
High C, low C
Plasma, extraction
6 days
IVD use in Europe (EEA)
7, low C, high C
Serum, plasma 100 µL
24 h
RUO, worldwide
7, low C, high C
Serum, plasma 100 µL
24 h
IVD use in Europe (EEA)
7, low C, high C
Serum, plasma 100 µL
24 h
RUO, worldwide
7, low C, high C
Serum, plasma 100 µL
24 h
RUO, worldwide
7, low C, high C
Plasma, extraction
48 h
RUO, worldwide
7, low C, high C
Plasma, extraction
48 h
IVD use in Europe (EEA) and US
7, low C, high C
Serum, 100 µL
2h
RUO, worldwide
7, low C, high C
Serum, 100 µL
2h
IVD use in Europe, US and Japan
7, low C, high C
Plasma
48 h
RUO, worldwide
7, low C, high C
Plasma
48 h
RUO, worldwide
7, low C, high C
Plasma, Liqvor, 100 µL
48 h
IVD use in Europe (EEA)
7, low C, high C
Serum, 200 µL
48 h
RUO, worldwide
7, low C, high C
Serum, 200 µL
48 h
IVD use in Europe (EEA)
7, low C, high C
Serum, 100 µL
48 h
RUO, worldwide
7, low C, high C
Serum, 100 µL
48 h
RUO, worldwide
7, low C, high C
Plasma, extraction
48 h
IVD use in Europe (EEA)
7, low C, high C
Plasma extraction, urine
48 h
RUO, worldwide
7, low C, high C
Plasma extraction, urine
48 h
IVD use in Europe (EEA)
7, low C, high C
Plasma, 200 µL
48 h
RUO, worldwide
7, low C, high C
Plasma, 200 µL
48 h
RIA CATALOG
I
15
Diagnostic solutions leader in autoimmunity testing
We thank you for your interest in our products and we commit ourselves to continually developing
and providing you with the highest quality innovative clinical solutions. www.eurodiagnostica.com
Euro Diagnostica AB
Mail address:
P.O. Box 50117
SE - 202 11 Malmö
Sweden
Visiting address:
Lundavägen 151
Malmö
Sweden
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+46 40 53 76 00
+46 40 43 22 88
[email protected]
www.eurodiagnostica.com
Doc No: E-083-GB01, June 2014