Download Avitron® V

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Avitron® V
Tablet
Description
Avitron V tablet contains Vitamin B1 or Thiamine Hydrochloride USP.
Thiamine Hydrochloride is a water soluble vitamin belongs to vitamin B
complex family. Thiamine in the form of Thiamine Pyrophosphate (also
known as cocarboxylase), is the co-enzyme for decarboxylation of α keto
acids. Thiamine pyrophosphate also acts as the co-enzyme of
transketolase in the direct oxidation pathway of glucose metabolism. In
thiamine deficiency, pyruvic acid and lactic acid accumulate in tissues.
Thiamine deficiency affects the peripheral nervous system, the
gastrointestinal tract, and the cardiovascular system.
Thiamine is not stored in the body, intracellular thiamine is present almost
entirely as the co-enzyme moiety of active enzymes. Thiamine
requirement is related to carbohydrate intake and the metabolic rate. A
daily intake of 400 µg thiamine per 1000 kcal is recommended. The total
requirement increases during periods of active growth or heavy physical
labour, during pregnancy and lactation, in pathological conditions such as
fever and hyperthyroidism and in other conditions causing increased
metabolism.
Indications
Avitron V is indicated in the treatment of the various manifestations of
thiamine deficiency such as beriberi (wet or dry) and Wernicke's
encephalopathy, neuritis associated with pregnancy and pellagra.
Supplementary thiamine may be indicated prophylactically in conditions
where there is low dietary intake or low gastrointestinal absorption of
thiamine, and increased thiamine requirement periods e.g.
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active growth
heavy physical labour
pregnancy and lactation
in pathological conditions such as fever and hyperthyroidism and other
conditions causing increased metabolism.
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Dosage and Administration
Mild chronic deficiency : 10-25 mg daily
Severe deficiency : 200-300 mg daily or as advised by the physician
Contraindication
Thiamine is contraindicated in patients with known hypersensitivity to it.
Side Effects
Vitamin B1 does not have adverse effects when given orally. A feeling of
warmth, pruritus, urticaria, weakness, sweating, nausea, restlessness etc.
may occur.
Use in Special Populations
Pregnancy and lactation : Thiamine is safe in pregnant women and
recommended for the treatment of neuritis in pregnancy. Although it is
not known if thiamine is excreted in breast milk, the drug may be taken
safely during lactation.
Commercial Pack
Avitron® V Tablet : Box containing 25 blister strips of 10 tablets. Each
tablet contains Thiamine Hydrochloride USP 100 mg.
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