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Rottlerin Size Cat. No. 10 mg 557370 Synonym: Mallotoxin Description: Inhibits protein kinase C δ (PKCδ, IC50 = 3-6 µM) and PKCθ isozymes. Also inhibits PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCξ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM). Form: Solid CAS Number: 82-08-6 RTECS: AM6913800 Molecular Weight: 516.5 Molecular Formula: C30H28O8 Structure: HO CH3 OH O OH O CH3 CH3 O CH3 OH OH Purity: ≥98% by TLC Solubility: DMSO and ethanol Storage: Refrigerate (+4°C). Following reconstitution, aliquot and freeze (-20°C). This product is stable for 2 years as supplied. Ethanol stock solutions are stable for up to 3 months at -20°C. Toxicity: MSDS available upon request. Merck Index: 12: 8429 Germany Tel 0800 6931 000 USA & Canada Tel (800) 628-8470 United Kingdom Tel 0115 9430 840 E-mail address for technical inquiries: [email protected] Find our current product data sheets on the web: http://www.calbiochem.com Revised: 16-Jul-01 CN: 557370 References: Villalba, M., et al. 1999. J. Immunol. 163, 5813. Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93. Gschwendt, M., et al. 1994. FEBS Lett. 338, 85. Gschwendt, M., et al. 1984. Cancer Lett. 25, 177. FOR RESEARCH USE ONLY. NOT FOR HUMAN OR DRUG USE.