Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Rottlerin
Document related concepts
Transcript
Rottlerin Size Cat. No. 10 mg 557370 Synonym: Mallotoxin Description: Inhibits protein kinase C δ (PKCδ, IC50 = 3-6 µM) and PKCθ isozymes. Also inhibits PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCξ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM). Form: Solid CAS Number: 82-08-6 RTECS: AM6913800 Molecular Weight: 516.5 Molecular Formula: C30H28O8 Structure: HO CH3 OH O OH O CH3 CH3 O CH3 OH OH Purity: ≥98% by TLC Solubility: DMSO and ethanol Storage: Refrigerate (+4°C). Following reconstitution, aliquot and freeze (-20°C). This product is stable for 2 years as supplied. Ethanol stock solutions are stable for up to 3 months at -20°C. Toxicity: MSDS available upon request. Merck Index: 12: 8429 Germany Tel 0800 6931 000 USA & Canada Tel (800) 628-8470 United Kingdom Tel 0115 9430 840 E-mail address for technical inquiries: [email protected] Find our current product data sheets on the web: http://www.calbiochem.com Revised: 16-Jul-01 CN: 557370 References: Villalba, M., et al. 1999. J. Immunol. 163, 5813. Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93. Gschwendt, M., et al. 1994. FEBS Lett. 338, 85. Gschwendt, M., et al. 1984. Cancer Lett. 25, 177. FOR RESEARCH USE ONLY. NOT FOR HUMAN OR DRUG USE.
