Download REFERENCES FOR DRUGS IN CATEGORY A ALLOPURINOL

REFERENCES FOR DRUGS IN CATEGORY A
ALLOPURINOL
Simmons F, Feldman B, Gerety D. Granulomatous hepatitis in a
patient receiving allopurinol. Gastroenterology 1972; 62: 101-4.
Young JL, Boswell RB, Nies AS. Severe allopurinol hypersensitivity.
Association with thiazides and prior renal compromise. Arch Intern
Med 1974; 134: 553-8.
McMenamin RA, Davies LM, Craswell PW. Drug induced interstitial
nephritis, hepatitis and exfoliative dermatitis. Aust N Z J Med 1976;
6: 583-7.
Boyer TD, Sun N, Reynolds TB. Allopurinol-hypersensitivity
vasculitis and liver damage. West J Med 1977; 126: 143-7.
Espiritu CR, Alalu J, Glueckauf LG, Lubin J. Allopurinol-induced
granulomatous hepatitis. Am J Dig Dis 1976; 21: 804-6.
Chawla SK, Patel HD, Parrino GR, Soterakis J, Lopresti PA, D'Angelo
WA. Allopurinol hepatotoxicity. Case report and literature review.
Arthritis Rheum 1977; 20: 1546-9.
Butler RC, Shah SM, Grunow WA, Tester EC. Massive hepatic
necrosis in a patient receiving allopurinol. JAMA 1977; 237: 473-4.
Shah SM, Butler RC, Grunow WA, Texter EC Jr. Massive hepatic
necrosis in a patient receiving concomitant medication. JAMA 1977;
237: 2036.
Swank LA, Chejfec G, Nemchausky BA. Allopurinol-induced
granulomatous hepatitis with cholangitis and a sarcoid-like reaction.
Arch Intern Med 1978; 138: 997-8.
Male PJ, Schaer B, Posternak R. Reaction d'hypersensibilite a
l'allopurinol. Schweiz Med Wochenschr 1978; 108: 661-3.
Medline A, Cohen LB, Tobe BA, Sellers EM. Liver granulomas and
allopurinol. Br Med J 1978; 108: 681-2.
Korting HC, Lesch R. Acute cholangitis after allopurinol treatment.
Lancet 1978; 1: 275-6.
Haughey DB, Lanse S, Imhoff T, Tobin M, Schentag JJ. Allopurinol
sensitivity: report of two cases. Am J Hosp Pharm 1979; 36: 137780.
Lang PG. Severe hypersensitivity reactions to allopurinol. South Med
J 1979; 72: 1361-8.
Olsen H, Mrland J. [Hepatic damages caused by allopurinol] Tidsskr
Nor Laegeforen 1980; 100: 562-3.
Al-Kawas FH, Seeff LB, Berendson RA, Zimmerman HJ, Ishak KG.
Allopurinol hepatotoxicity. Report of two cases and review of
literature. Ann Intern Med 1981; 95: 588-90.
Shah KA, Levin J, Rosen N, Greenwald E, Zumoff B. Allopurinol
hepatotoxicity potentiated by tamoxifen. N Y State J Med 1982; 82:
1745-6.
Ramond MJ, Nouel O, Degott C, Lebrec D, Benhamou JP.
[Allopurinol-induced hepatitis. Report of a case and review of the
literature (author's transl)] Gastroenterol Clin Biol 1982; 6: 138-42.
Raper R, Ibels L, Lauer C, Barnes P, Lunzer M. Fulminant hepatic
failure due to allopurinol. Aust NZ J Med 1984; 14: 63-5.
Hande KR, Noone RM, Stone WJ. Severe allopurinol toxicity.
Description and guidelines for prevention in patients with renal
insufficiency. Am J Med 1984; 76: 47-56.
Ohsawa T, Ohtsubo M. Hepatitis associated with allopurinol. Drug
Intell Clin Pharm 1985; 19: 431-3.
Mousson C, Justrabo E, Tanter Y, Chalopin JM, Rifle G. [Acute
granulomatous interstitial nephritis and hepatitis caused by drugs.
Possible role of an allopurinol-furosemide combination] Nephrologie
1986; 7: 199-203.
Vanderstigel M, Zafrani ES, Lejonc JL, Schaeffer A, Portos JL.
Allopurinol hypersensitivity syndrome as a cause of hepatic fibrinring granulomas. Gastroenterol 1986; 90: 188-90.
Pewsner D, Bachmann C, Müller U. [Allopurinol-induced kidney
failure with hepatitis and squamous dermatitis in pre-existing
kidney insufficiency] Schweiz Med Wochenschr 1987; 117: 139-41.
Olmos M, Guma C, Colombato LO, Lami G, Miyashiro R, Alvarez E.
[Hepatic lesions induced by drugs. Report of 26 cases] Acta
Gastroenterol Latinoam 1987; 17: 105-11. Spanish.
Stricker BH, Blok AP, Babany G, Benhamou JP. Fibrin ring
granulomas and allopurinol. Gastroenterology 1989; 96: 1199-203.
González Ramallo VJ, Rodríguez Gorostiza FJ, Muiño Míguez A,
López de la Riva M. [Severe cholestasis caused by allopurinol] Rev
Esp Enferm Apar Dig 1989; 75: 317-8. Spanish.
Tam S, Carroll W. Allopurinol hepatotoxicity. Am J Med 1989; 86:
357-8.
Arellano F, Sacristán JA. Allopurinol hypersensitivity syndrome: a
review. Ann Pharmacother 1993; 27: 337-43
Berbegal J, Morera J, Andrada E, Navarro V, Lluch V, López-Benito
I. [Syndrome of allopurinol hypersensitivity. Report of a new case
and review of the Spanish literature] Med Clin (Barc) 1994; 102:
178-80. Spanish.
Lee SS, Lin HY, Wang SR, Tsai YY. Allopurinol hypersensitivity
syndrome. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi.
1994; 27: 140-7.
González U, Reyes E, Kershenovich J, Orozco-Topete RL.
[Hypersensitivity syndrome caused by allopurinol. A case of massive
hepatic necrosis] Rev Invest Clin 1995; 47: 409-13. Spanish.
Paitel JF, Trechot P, Stockemer V, Dorvaux V, Lederlin P. [Acute
liver disease during treatment with pipobroman and allopurinol]
Presse Med. 1995; 24:460.
Urban T, Maquarre E, Housset C, Chouaid C, Devin E, Lebeau B.
[Allopurinol hypersensitivity. A possible cause of hepatitis and
mucocutaneous eruptions in a patient undergoing antitubercular
treatment] Rev Mal Respir 1995; 12: 314-6.
Wade B, Klotz F, Debonne JM, Aubert M. [Fatal hepatitis due to
allopurinol in Dakar] Med Trop (Mars) 1995; 55: 186-7.
Andrade RJ, de la Mata M, Lucena MI, López-Rubio F, Corrales MA.
[Severe acute hepatitis due to allopurinol in a patient with
asymptomatic hyperuricemia and kidney failure. A review of the
literature and an analysis of the risk factors] Gastroenterol Hepatol
1997; 20: 353-6.
Pluim HJ, van Deuren M, Wetzels JFM. The allopurinol
hypersensitivity syndrome. Neth J Med 1998; 52: 107-110.
Kluger E. [Fatal outcome in allopurinol hypersensitivity syndrome]
Ugeskr Laeger 1998; 160: 1179-80. Danish.
Pereira S, Almeida J, Silva AO, Quintas M, Candeias O, Freitas F.
[Fatal liver necrosis due to allopurinol] Acta Med Port 1998; 11:
1141-4. Portuguese.
Khoo BP, Leow YH. A review of inpatients with adverse drug
reactions to allopurinol. Singapore Med J 2000; 41: 156-60.
Hammer B, Link A, Wagner A, Böhm M. [Hypersensitivity syndrome
during therapy with allopurinol in asymptomatic hyperuricemia with
a fatal outcome] Dtsch Med Wochenschr 2001; 126: 1331-4.
German.
Descamps V, Valance A, Edlinger C, Fillet AM, Crossin M, LerunVignes B, Belatch S, et al. Association of human herpesvirus 6
infection with drug reaction with eosinophilia and systemic
symptoms. Arch Dermatol 2001; 137: 301-4.
Vázquez-Mellado J, Morales EM, Pacheco-Tena C, Burgos-Vargas R.
Relation between adverse events associated with allopurinol and
renal function in patients with gout. Ann Rheum Dis 2001; 60: 9813.
Muller P, Dubreil P, Mahé A, Lamaury I, Salzer B, Deloumeaux J,
Strobel M. Drug hypersensitivity syndrome in a West-Indian
population. Eur J Dermatol 2003; 13: 478-81.
Descamps V, Mahe E, Houhou N, Abramowitz L, Rozenberg F,
Ranger-Rogez S, Crickx B. Drug-induced hypersensitivity syndrome
associated with Epstein-Barr virus infection. Br J Dermatol 2003;
148: 1032-4.
Mete N, Yilmaz F, Gulbahar O, Avdin A, Sin A, Kokuludaq A, Yuce G,
Sebik F. Allopurinol hypersensitivity syndrome as a cause of hepatic
centrilobular hemorrhagic necrosis. J Investig Allergol Clin Immunol
2003; 13: 281-3.
Russo MW, Galanko JA, Shrestha R, Fried MW, Watkins P. Liver
transplantation for acute liver failure from drug-induced liver injury
in the United States. Liver Transpl 2004; 10: 1018-23.
Gutiérrez-Macías A, Lizarralde-Palacios E, Martínez-Odriozola P,
Miguel-De la Villa F. Fatal allopurinol hypersensitivity syndrome
after treatment of asymptomatic hyperuricaemia. BMJ 2005; 331:
623-4.
Saxena R, Loghmanee F. Fatal drug reaction due to allopurinol
therapy in a 72-year-old man. Arch Pathol Lab Med 2005; 129:
e183-4.
Choi SH, Yang SH, Song YB, Kim HJ, Seo YT, Choi DS, Moon KH, et
al. Allopurinol therapy and vanishing bile duct syndrome. Korean J
Hepatol 2005; 11: 80-85
Chiou CC, Yang LC, Hung SI, Chang YC, Kuo TT, Ho HC, Hu S, et al.
Clinicopathological features and prognosis of drug rash with
eosinophilia and systemic symptoms: a study of 30 cases in Taiwan.
J Eur Acad Dermatol Venereol 2008; 22: 1044-9.
Halevy S, Ghislain PD, Mockenhaupt M, Fagot JP, Bouwes Bavinck
JN, Sidoroff A, Naldi L, et al; EuroSCAR Study Group. Allopurinol is
the most common cause of Stevens-Johnson syndrome and toxic
epidermal necrolysis in Europe and Israel. J Am Acad Dermatol
2008; 58: 25-32.
Kaniwa N, Saito Y, Aihara M, Matsunaga K, Tohkin M, Kurose K,
Sawada J, et al; JSAR research group. HLA-B locus in Japanese
patients with anti-epileptics and allopurinol-related Stevens-Johnson
syndrome and toxic epidermal necrolysis. Pharmacogenomics 2008;
9: 1617-22.
Shalom R, Rimbroth S, Rozenman D, Markel A. Allopurinol-induced
recurrent DRESS syndrome: pathophysiology and treatment. Ren
Fail 2008; 30: 327-9.
Khanlari B, Bodmer M, Terracciano L, Heim MH, Fluckiger U,
Weisser M. Hepatitis with fibrin-ring granulomas. Infection 2008;
36: 381-3.
Yoon JY, Min SY, Park JY, Hong SG, Park SJ, Paik SY, Park YM. [A
case of allopurinol-induced granulomatous hepatitis with ductopenia
and cholestasis] Korean J Hepatol 2008; 14: 97-101.
Lonjou C, Borot N, Sekula P, Ledger N, Thomas L, Halevy S, Naldi L,
et al; RegiSCAR study group. A European study of HLA-B in
Stevens-Johnson syndrome and toxic epidermal necrolysis related
to five high-risk drugs. Pharmacogenet Genomics 2008; 18: 99107.
Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J,
Reddy KR, Watkins PB, Navarro V, Barnhart H, Gu J, Serrano J
Features and Outcomes of 889 Patients with Drug-induced Liver
Injury: The DILIN Prospective Study. Gastroenterology. 2015 Mar 6.
pii: S0016-5085(15)00311-X.
Tausche AK, Aringer M, Schroeder HE, Bornstein SR, Wunderlich C,
Wozel G. The Janus faces of allopurinol-allopurinol hypersensitivity
syndrome. Am J Med 2008 ; 121: e3-4.
Eshki M, Allanore L, Musette P, Milpied B, Grange A, Guillaume JC,
Chosidow O, et al. Twelve-year analysis of severe cases of drug
reaction with eosinophilia and systemic symptoms: a cause of
unpredictable multiorgan failure. Arch Dermatol 2009; 145: 67-72.
Gyotoku E, Iwamoto T, Ochi M. [A fatal case of drug-induced
hypersensitivity syndrome due to allopurinol]. Arerugi 2009; 58:
560-6. Japanese.
Um SJ, Lee SK, Kim YH, Kim KH, Son CH, Roh MS, Lee MK. Clinical
features of drug-induced hypersensitivity syndrome in 38 patients. J
Investig Allergol Clin Immunol 2010; 20: 556-62.
Reuben A, Koch DG, Lee WM; Acute Liver Failure Study Group.
Drug-induced acute liver failure: results of a U.S. multicenter,
prospective study. Hepatology 2010; 52: 2065-76.
Botelho LF, Higashi VS, Padilha MH, Enokihara MM, Porro AM.
DRESS: clinicopathological features of 10 cases from an University
Hospital in São Paulo. An Bras Dermatol 2012; 87: 703-7.
Yaylacı S, Demir MV, Temiz T, Tamer A, Uslan MI. Allopurinolinduced DRESS syndrome. Indian J Pharmacol 2012; 44: 412-4.
Stamp LK, Taylor WJ, Jones PB, Dockerty JL, Drake J, Frampton C,
Dalbeth N. Starting dose is a risk factor for allopurinol
hypersensitivity syndrome: a proposed safe starting dose of
allopurinol. Arthritis Rheum 2012; 64: 2529-36.
Wongkitisophon P, Chanprapaph K, Rattanakaemakorn P,
Vachiramon V. Six-year retrospective review of drug reaction with
eosinophilia and systemic symptoms. Acta Derm Venereol 2012;
92: 200-5.
Bollaert M, Jeulin H, Waton J, Gastin I, Tréchot P, Rabaud C,
Schmutz JL, Barbaud A. [Six cases of spring DRESS]. Ann Dermatol
Venereol 2012; 139: 15-22.
Kardaun SH, Sekula P, Valeyrie-Allanore L, Liss Y, Chu CY, Creamer
D, Sidoroff A, et al; The RegiSCAR study group. Drug Reaction with
Eosinophilia and Systemic Symptoms (DRESS): an original
multisystem adverse drug reaction. Results from the prospective
RegiSCAR study. Br J Dermatol 2013; 169: 1071-80.
Ramasamy SN, Korb-Wells CS, Kannangara DR, Smith MW, Wang
N, Roberts DM, Graham GG, Williams KM, Day RO. Allopurinol
Hypersensitivity: A Systematic Review of All Published Cases, 19502012. Drug Saf 2013; 36: 954-80.
Walsh S, Diaz-Cano S, Higgins E, Morris-Jones R, Bashir S, Bernal
W, Creamer D. Drug reaction with eosinophilia and systemic
symptoms: is cutaneous phenotype a prognostic marker for
outcome? A review of clinicopathological features of 27 cases. Br J
Dermatol 2013; 168: 391-401.
Choi HG, Byun J, Moon CH, Yoon JH, Yang KY, Park SC, Han CJ.
Allopurinol-induced DRESS syndrome mimicking biliary obstruction.
Clin Mol Hepatol 2014; 20: 71-5.
Gonçalo M, Coutinho I, Teixeira V, Gameiro AR, Brites MM, Nunes R,
Martinho A. HLA-B*58:01 is a risk factor for allopurinol-induced
DRESS and Stevens-Johnson syndrome/toxic epidermal necrolysis
in a Portuguese population. Br J Dermatol 2013; 169: 660-5.
AMIODARON
Lim PK, Trewby PN, Storey GC, Hole DW. Neuropathy and fatal
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Patterson J, Blendis L, Phillips MJ. Amiodarone-associated
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Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J,
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NILUTAMIDE
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PANTOPRAZOLE
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PHENELZINE
Holdswoth CD, Atkinson M, Goldie W. Hepatitis caused by the newer
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PIOGLITAZONE
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PRAVASTATIN
Hartleb M, Rymarczyk G, Januszewski K. Acute cholestatic hepatitis
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PREGABALIN
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Features and Outcomes of 889 Patients with Drug-induced Liver
Injury: The DILIN Prospective Study. Gastroenterology. 2015 Mar 6.
pii: S0016-5085(15)00311-X.
PROCAINAMIDE
Zimmerman HJ. Antiarrhythmics. Drugs used in cardiovascular
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PROCHLORPERAZINE
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PYRIMETHAMINE
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QUIETAPINE
El Hajj I, Sharara AI, Rockey DC. Subfulminant liver failure
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RAMIPRIL
Douros A, Kauffmann W, Bronder E, Klimpel A, Garbe E, Kreutz R.
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RISPERIDONE
Fuller MA, Simon MR, Freedman L. Risperidone-associated
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RITONAVIR
Carr A, Cooper DA. Restoration of immunity to chronic hepatitis B
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ROSIGLITAZONE
Al-Salman J, Arjomand H, Kemp DG, Mittal M. Hepatocellular injury
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SALSALATE
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Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J,
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pii: S0016-5085(15)00311-X.
SORAFENIB
Schramm C, Schuch G, Lohse AW. Sorafenib-induced liver failure.
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TEMOZOLOMIDE
Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T,
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Int J Antimicrob Agents. 2003 Jun;21(6):596-7.
EXEMESTANE
Rabaglio M, Ruepp B; Soft/Text/Perche Steering Committee. Death due to
liver failure during endocrine therapy for premenopausal breast cancer. Acta
Oncol 2010; 49: 874-6.
Fosinopril
SchoondykeJW, Mohan R, Kelly JL, Ponder MA, Iskandar S, Douglas JE.
Fosinopril- induced hepatotoxicity in acomplex medical patient. Tenn Med.
2002Apr;95(4):155-6.
Gliclazide
Caksen H, Kendirci M, Tutus A, Uzüm K, Kurtoglu S. Gliclazide-induced
hepatitis, hemiplegia and dysphasia in a suicide attempt. J Pediatr Endocrinol
Metab 2001; 14: 1157-9.
Hydrochorothiazide
Arinzon Z, Alexander P, Berner Y. Hydrochlorothiazide induced hepatocholestatic liver injury. Age Ageing 2004; 33: 509-10.
Lapatinib
Shah RR, Morganroth J, Shah DR.Hepatotoxicity of tyrosine kinase
inhibitors:clinical and regulatory perspectives. Drug Saf. 2013
Jul;36(7):491-503.
Spraggs CF, Parham LR, Hunt CM, Dollery CT. Lapatinib - induced liver injury
characterized byclass II HLA and Gilbert's syndrome genotypes. Clin
Pharmacol Ther. 2012 Apr;91(4):647-52.
LOPINAVIR
Kottilil S, Polis MA, Kovacs JA. HIV Infection, hepatitis C infection, and
HAART: hard clinical choices. JAMA 2004; 292:243-50.
Mefloquine
Gotsman I, Azaz-Livshits T, Fridlender Z, Muszkat M, Ben-Chetrit E.
Mefloquine-induced acute hepatitis. Pharmacotherapy 2000; 20: 1517-9.
Mithramycin
Green L, Donehower RC. Hepatic toxicity of low doses of mithramycin in
hypercalcemia. Cancer Treat Rep. 1984 Nov;68(11):1379-81.
Nelfinavir
Trapé M, Barnosky S. Nelfinavir in expanded postexposure prophylaxis
causing acute hepatitis with cholestatic features: two case reports.
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Pentostatin
Sanchez M, Orero M, Marco J, Simó, Linares M, Carbonell F. Fulminant
hepatic failure after 2'-deoxycoformycin(pentostatin). Br J Haematol 1999;
105: 316.
Propofol
Motsch J, Schmidt H, Bach A, Böttiger BW, Böhrer H. Long-term sedation
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11: 499-502.
Müller C, Jelinek T, Endres S, Loeschke K. [Severe protracted cholestasis
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RABEPRAZOLE
Johnstone D, Berger C, Fleckman P. Acute fulminant hepatitis after
treatment with rabeprazole and terbinafine. Arch Intern Med 2001; 161:
1677-8.
RALTEGRAVIR
Mateo-Carrasco H, Gálvez-Contreras MC, Fernández-Ginés FD, Nguyen TV.
Elevated liver enzymes resulting from an interaction between Raltegravir
and Panax ginseng: a case report and brief review.
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Sirolimus
Yaich S, El Aoud N, Zaghdane S, Charfeddine K, Kharrat M, Masmoudi M,
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Niemczyk M, Wyzgał J, Perkowska A, Porowski D, Paczek L. Sirolimusassociated hepatotoxicity in the kidney graft recipient. Transpl Int. 2005
Nov;18(11):1302-3.
Neff GW, Ruiz P, Madariaga JR, Nishida S, Montalbano M, Meyer D, Levi DM,
Tzakis AG, O'Brien CB. Sirolimus-associated hepatotoxicity in liver
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Sunitinib
Mueller EW, Rockey ML, Rashkin MC. Sunitinib-related fulminant hepatic
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Mermershtain W, Lazarev I, Shani-Shrem N, Ariad S. Fatal liver failure in a
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Daghfous R, El Aidli S, Zaiem A, Loueslati MH, Belkahia C. Sildenafilassociated hepatotoxicity. Am J Gastroenterol. 2005 Aug;100(8):1895-6.
TACROLIMUS
Kusumi E, Kami M, Kanda Y, Murashige N, Seki K, Fujiwara M, Koyama R,
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Ganschow R, Albani J, Grabhorn E, Richter A, Burdelski M. Tacrolimusinduced cholestatic syndrome following pediatric liver transplantation and
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Oto T, Okazaki M, Takata K, Egi M, Yamane M, Toyooka S, Sano Y, Snell GI,
Goto K, Miyoshi S. Calcineurin inhibitor-related cholestasis complicating lung
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Thiotepa
Lee JL, Gooley T, Bensinger W, Schiffman K, McDonald GB. Veno-occlusive
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Triazolam
Cobden I, Record CO, White RWB. Fatal intrahepatic cholestasis associated
with triazolam. Postgrad Med J 1981; 57: 730-1
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Gómez NA, Mejillón JL, Zapatier JA, Vargas PE.[Biliary stenosis, hepatitis A
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Fujita Y, Hasegawa M, Nabeshima K, Tomita M, Murakami K, Nakai S,
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Patterson JP. Amoxapine associated with hepatotoxicity. J Clin
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Pavel S, Burty C, Alcaraz I, de la Tribonnière X, Baclet V, Ajana F, Mouton
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Hayes D Jr, McConnell PI, Preston TJ, Nicol KK.
Hyperbilirubinemia complicating plasma-free hemoglobin and antifactor Xa
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Mahapatra S, Belgrad JL, Adeoye MA. Psychotropic drug-related
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Atovaquone
Grieshaber M, Lämmli J, Marcus L. Acute hepatitis and
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Hubbard SP, Chabner BA, Canellos GP, Young RC, DeVita VT Jr. High dose
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Aleem A, Al-Katari M, Alsaleh K, AlSwat K, Al-Sheikh A. Vanishing bile
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Gurzu S1, Jung I, Comsulea M, Kadar Z, Azamfirei L, Molnar C. Lethal
cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis
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Lokich JJ, Drum DE, Kaplan W. Hepatic toxicity ofnitrosourea analogues.
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McIntyre RE, Magidson JG, Austin GE, Gale RP. Fatal veno-occlusive
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Combe C, Banas B, Zoller WG, Manns MP, Schlöndorff D. [Antibioticinduced prolonged cholestasis: suspected induction by ceftibuten]. Z
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CLOFARABINE
Johnston DL, Mandel KM. Fatal skin and liver toxicity in a patient treated
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PROBABLY UNLIKELY: HEP A, B AND C NOT INCLUDED
Parker JLW. Potassium clorazepate (Tranxene)-induced jaundice. Acute
hepatitis-like injury due to clorazepate. Postgrad Med J 1979; 55: 908910.
Desipramine
Powell WJ, Koch-Weser J, Williams RA. Lethal hepatic necrosis after
therapy with imipramine and desipramine. JAMA 1968; 206: 642-5.
Price LH, Nelson JC, Waltrip RW. Desipramine-associated hepatitis. J Clin
Psychopharmacol. 1983 Aug;3(4):243-6. Blood transfusion 6 months
earlier in case 1, parenteral drug use in case 2.
Remy AL, Larrey D, Pageaux GP, Desprez D, Ramos J, Michel H. Cross
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Gastroenterol 1995; 7: 373-6.
Diazepam
Fors B, Nilsson F. [Hepatitis probably induced by diazepam medication]
Lakartidningen 1968; 65: 4528-31. Swedish.
Cunningham ML. Acute hepatic necrosis following treatment with
amitriptyline and diazepam. Brit J Psychiat 1965; 111: 1107-9.
Dydrogesterone
Altintaş E, Oğuz D, Kaçar S, Ozderin Y, Sezgin O, Zengin NI.
Dydrogesterone-induced hepatitis and autoimmune hemolytic anemia.
Turk J Gastroenterol. 2004 Mar;15(1):49-52.
Ethosuximide
Coulter DL. Ethosuximide-induced liver dysfunction. Arch Neurol 1983;
40: 393-4.
Conilleau V, Dompmartin A, Verneuil L, Michel M, Leroy D.
Hypersensitivity syndrome due to 2 anticonvulsant drugs. Contact
Dermatitis 1999; 41: 141-4.
Flucytosine
Record CO, Skinner JM, Sleight P, Speller DCE. Candida endocarditis
treated with 5-fluorocytosine. Br Med J 1971; 1: 262-4.
Fluphenazine
Walters GM, Terrence C, Steckel R. Jaundice followingadministration of
fluphenazine dihydrochloride. Am J Psychiatry 1963; 120: 81-2.
Snyder S. Fluphenazine jaundice. Report of a case. Am J Gastroenterol
1980; 73: 336-40.
Holt RJ. Fluphenazine decanoate-induced cholestatic jaundice and
thrombocytopenia. Pharmacotherapy 1984; 4: 227-9.
Aruna AS, Murungi JH. Fluphenazine-induced neuroleptic malignant
syndrome in a schizophrenic patient. Ann Pharmacother 2005; 39: 11315.
Fluvoxamine
Lam KS, Blanchi A, Chavaillon JM. [Hepatitis probably secondary to the
massive ingestion of fluvoxamine]. Gastroenterol Clin Biol 1988; 12: 3989.
Indinavir
Bräu N, Leaf HL, Wieczorek RL, Margolis DM. Severe hepatitis in three
AIDS patients treated with indinavir. Lancet. 1997 Mar
29;349(9056):924-5.
Vergis E, Paterson DL, Singh N. Indinavir-associated hepatitis in patients
with advanced HIV infection. Int J STD AIDS 1998; 9:53.
Lithium
Warick LH. Lithium poisoning. Report of a case with neurologic, cardiac
and hepatic sequelae. West J Med 1979; 130: 259-63.
Kosson H, Chou JC-Y. Abnormal liver function tests associated with lithium
treatment. J Clin Psychopharmacol 1992; 12: 216-7.
Isocarboxazid
Knight JA. Drug-induced hepatic injury. Marplan hepatitis. Am J Psychiatry
1961; 118: 73-4.
Maraviroc
Horster S, Goebel FD. Serious doubts on safety and efficacy of CCR5
antagonists: CCR5 antagonists teeter on a knife-edge. Infection 2006; 34;
110-3.
Mangiafico L, Perja M, Fusco F, Riva S, Mago D, Gringeri A. Safety and
effectiveness of raltegravir in patients with haemophilia and anti-HIV
multidrug resistance. Haemophilia 2012; 18: 108-11.
Minoxidil
David J. DiSantis, John Flanagan. Minoxidil-induced Stevens-Johnson
syndrome. Arch Intern Med 1981; 141: 1515.
Piperacillin
Schneider M, Helbling A, Zimmermann A, Krähenbühl S. Cholangiopathy
after short-term administration of piperacillin and imipenem/cilastatin.
Liver 2001; 21: 213-6).
Dietze MA, Martin P, Schaaf-Lafontaine N. [Clinical case of the
month. Cholestatic hepatitis after administration of piperacillin]. Rev Med
Liege 2002; 57: 571-4. French.
PROBENEZID
Reynolds ES, Schlant RC, Gonick HC, Dammin GJ. Fatal massive necrosis
of the liver as a manifestation of hypersensitivity to probenecid. N Engl J
Med 1957; 256: 592-6.
Proguanil
Grieshaber M, Lämmli J, Marcus L. Acute hepatitis and
atovaquone/proguanil. J Travel Med 2005; 12: 289-90.
Wielgo-Polanin R, Lagarce L, Gautron E, Diquet B, Lainé-Cessac P.
Hepatotoxicity associated with the use of a fixed combination of
chloroquine and proguanil. Int J Antimicrob Agents 2005; 26: 176-8.
Propranolol
Epeirier JM, Pageaux GP, Coste V, Perrigault PF, Banc P, Larrey D, Michel
H. Fulminant hepatitis after carbimazole and propranolol administration.
Eur J Gastroenterol Hepatol. 1996 Mar;8(3):287-8.
Kunze KD, Porst H, Tschöpel L.[Morphology and pathogenesis of liver
injury produced by dihydralazine , propranolol and ketophenylbutazone].
Zentralbl Allg Pathol. 1985;130(6):509-18. German.
RISEDRONATE
Phillips MB. Risedronate-induced hepatitis. Am J Med 2007; 120: e1-2.
Sumatriptan
Deixler E, Helmke K. [Extrahepatic cholestasis during therapy with
zolmitriptan (AscoTop)]. Z Gastroenterol 2005; 43: 1045-9. German.
Tolbutamide
Baird RW, Hull JG. Cholestatic jaundice from tolbutamide. Ann Intern Med
1960; 53: 194.
McMahon TF. Cholestatic jaundice, liver decompensation, and shock
resulting from tolbutamide: report of a case. Med Ann DC 1963; 509.
Balodimos MC, Camerini-Dávalos RA, Marble A. Nine years. experience
with tolbutamide in the treatment of diabetes. Metabolism 1966; 15: 95770.
Gregory DH, Zaki GF, Sarosi GA, Carey JB Jr. Chronic cholestasis following
prolonged tolbutamide administration. Arch Pathol 1967; 84: 194.
Ananth JV, Ban TA, Lehmann HE. Tolbutamide jaundice associated with
multiple drug therapy. Can Med Assoc J 1970; 103: 1194.
Tipranavir
Jülg B, Bogner JR, Goebel FD. Severe hepatotoxicity associated with the
combination of enfuvirtide and tipranavir/ritonavir: case report. AIDS
2006; 20:1563.
Tramadol
Loughrey MB, Loughrey CM, Johnston S, O'Rourke D. Fatal hepatic failure
following accidental tramadol overdose. Forensic Sci Int 2003; 134: 2323.
De Decker K, Cordonnier J, Jacobs W, Coucke V, Schepens P, Jorens PG.
Fatal intoxication due to tramadol alone: case report and review of the
literature. Forensic Sci Int. 2008 Feb 25;175(1):79-82.
Triazolam
Cobden I, Record CO, White RWB. Fatal intrahepatic cholestasis
associated with triazolam. Postgrad Med J 1981; 57: 730-1.
Lewis JH, Zimmerman HJ. Drug- and chemical-induced cholestasis. Clin
Liver Dis 1999; 3: 433-64, vii. Erratum in: Clin Liver Dis 1999; 3: 917.
Trifluoperazine
Kohn N, Myerson RM. Cholestatic hepatitis associated with trifluoperazine.
N Engl J Med 1961; 264: 549-50.
Margulies AI, Berris B. Jaundice associated with the administration of
trifluoperazine. Can Med Assoc J 1968; 98: 1063-4.
Valganciclovir
Shea BF, Hoffman S, Sesin GP, Hammer SM. Ganciclovir hepatotoxicity.
Pharmacotherapy 1987; 7: 223-6.
Vardenafil
Shea BF, Hoffman S, Sesin GP, Hammer SM. Ganciclovir hepatotoxicity.
Pharmacotherapy 1987; 7: 223-6.
Zolmitriptan
Deixler E, Helmke K. Recurrent jaundice in a patient taking zolmitriptan
for migraine headaches. [Extrahepatic cholestasis during therapy with
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Zolpidem
Karsenti D, Blanc P, Bacq Y, Metman EH. Hepatotoxicity associated with
zolpidem treatment. BMJ 1999; 318(7192): 1179.
No
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
Ingredient
Abatacept*
Acamprosate
Acrivastine
Adefovir
Albuterol
Alefacept*
Alemtuzumab
Alendronic acid
Almotriptan
Altretamine*
Amantadine
Ambrisentan
Amikacin
Amiloride
Aminophylline
Amobarbital
Amoxapine
Amprenavir/Fosamprenavir
Anidulafungin
Apomorphine
Aprepitant/Fosaprepitant
Aripiprazole*
Artemether*
Atovaquone*
Atropine
Azacitidine*
Aztreonam*
Basiliximab
Bendroflumethiazide
Benzphetamine
Benztropine
Betaxolol
Bevacizumab
Biperiden
Bisacodyl
Bisoprolol
Bitolterol
Bleomycin*
Brompheniramine/Dexbrompheniramine
Bumetanide
Buspirone*
Butalbital
Butobarbital
Butorphanol
Caffeine
Capecitabine*
Capreomycin
Year
2005
2004
1994
2002
1981
2001
1995
2003
2001
1990
1968
2007
1981
1986
1940
<1980
1992
1999
2006
2004
2003
2002
2008
1992
<1960
2004
1986
1998
1959
1960
1954
1985
2004
1959
2004
1992
<1980
1973
1971
1983
1986
1990
<1980
1978
1998
1971
Classification
Immunomodulatory
Substance abuse agent
Respiratory
Antimicrobial
Respiratory
Immunomodulatory
Immunomodulatory
Endocrine
CNS
Antineoplastic
CNS
Respiratory
Antimicrobial
Cardiovascular
Respiratory
CNS
CNS
Antimicrobial
Antimicrobial
CNS
Gastrointestinal
CNS
Antimicrobial
Antimicrobial
Cardiovascular
Antineoplastic
Antimicrobial
Immunomodulatory
Cardiovascular
Weight loss agent
CNS
Cardiovascular
Antineoplastic
CNS
Gastrointestinal
Cardiovascular
Respiratory
Antineoplastic
Respiratory
Cardiovascular
CNS
CNS
CNS
Analgesic
CNS
Antineoplastic
Antimicrobial
No
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
Ingredient
Carbidopa
Carbinoxamine
Carisoprodol
Carmustine*
Caspofungin
Cefditoren*
Cefixime*
Cefoxitin*
Cefpodoxime*
Ceftibuten*
Ceftizoxime*
Cephradine*
Certolizumab pegol*
Cetuximab
Chloral hydrate
Chlorpheniramine/Dexchlorpheniramine
Chlortetracycline*
Chlorthalidone
Cholestyramine*
Cidofovir
Cilastatin
Cisapride
Cladribine
Clemastine
Clonidine
Clorazepate
Cobicistat
Codeine
Colchicine
Colesevelam
Colestipol
Cyclobenzaprine
Darifenacin
Darunavir*
Daunorubicin*
Decitabine*
Delavirdine*
Demeclocycline*
Desipramine*
Desirudin
Diazepam
Dicyclomine
Diethylpropion
Dihydroergotamine
Dimenhydrinate
Dimercaprol
Diphenhydramine
Year
1966
<1980
1959
1977
2001
2001
1989
1991
1995
1998
1971
1974
2008
2002
<1960
1971
<1960
1960
1973
1996
1985
1993
1977
1974
1972
2012
<1960
1961
2000
1977
1977
2004
2003
1979
2006
1997
1960
1964
2003
1963
1996
1959
1946
2004
1946
1946
Classification
CNS
Respiratory
CNS
Antineoplastic
Antimicrobial
Antimicrobial
Antimicrobial
Antimicrobial
Antimicrobial
Antimicrobial
Antimicrobial
Antimicrobial
Immunomodulatory
Antineoplastic
CNS
Respiratory
Antimicrobial
Cardiovascular
Cardiovascular
Antimicrobial
Antimicrobial
Gastrointestinal
Antineoplastic
Respiratory
Cardiovascular
CNS
Antimicrobial
Analgesic
Rheumatologic
Cardiovascular
Cardiovascular
CNS
Urologic
Antimicrobial
Antineoplastic
Antineoplastic
Antimicrobial
Antimicrobial
CNS
Hematologic
CNS
Gastroinestinal
Weight loss agent
CNS
CNS
Toxicology
CNS
No
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
Ingredient
Diphenoxylate
Docusate
Dolasetron
Doxazosin
Doxylamine
Dronabinol
Dutasteride
Eletriptan
Emtricitabine
Enfuvirtide
Entecavir
Epirubicin*
Eplerenone
Eprosartan
Ergotamine
Ertapenem*
Esmolol
Estazolam
Eszopiclone
Ethacrynate
Ethosuximide
Etidronate
Everolimus
Famciclovir
Felodipine
Fentanyl
Fesoterodine
Fexofenadine
Finasteride
Flavoxate
Flucytosine
Fludarabine*
Fluphenazine*
Fluvoxamine*
Formoterol
Foscarnet
Fosfestrol*
Frovatriptan
Furosemide
Galantamine
Ganciclovir/Valganciclovir
Gentamicin
Glycopyrrolate
Golimumab*
Granisetron
Griseofulvin
Guanethidine
Year
1960
<1980
1997
2007
1948
1985
2001
2002
2006
2003
2005
1999
2002
1997
<1960
2001
1986
1991
2004
1967
1960
1977
2009
1994
1991
1968
2008
1996
1992
1970
1971
1991
1972
1994
2006
1991
2001
1966
2001
1994
1970
1961
2009
1993
2007
1960
Classification
Gastrointestinal
Gastrointestinal
Gastrointestinal
Cardiovascular
CNS
Gastrointestinal
Urologic
CNS
Antimicrobial
Antimicrobial
Antimicrobial
Antineoplastic
Cardiovascular
Cardiovascular
CNS
Antimicrobial
Cardiovascular
CNS
CNS
Cardiovascular
CNS
Endocrine
Immunomodulatory
Antimicrobial
Cardiovascular
Analgesic
Urologic
Respiratory
Urologic
Urologic
Antimicrobial
Antineoplastic
CNS
CNS
Respiratory
Antimicrobial
Antineoplastic
CNS
Cardiovascular
CNS
Antimicrobial
Antimicrobial
Respiratory
Immunomodulatory
Gastrointestinal
Antimicrobial
Cardiovascular
No
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
Ingredient
Homatropine
Hydrocodone
Hydromorphone
Hydroxyzine
Hyoscyamine
Ibandronate
Idarubicin*
Indapamide
Indinavir*
Ipratropium
Isocarboxazid*
Isradipine
Ketorolac*
Lamivudine
Levamisole*
Levodopa
Levorphanol
Liraglutide
Lithium
Lomefloxacin
Loperamide
Loratadine/Desloratadine
Lorazepam
Loxapine
Lubiprostone
Maraviroc*
Mechlorethamine*
Meclizine
Mepenzolate
Meperidine
Meprobamate
Metaproterenol
Metaxalone
Methadone
Methocarbamol
Methscopolamine
Methysergide
Metoclopramide*
Metolazone
Mezlocillin*
Midazolam
Miglitol
Minoxidil
Modafinil/Armodafinil
Moexipril
Morphine
Muromonab-CD3
Year
<1980
1998
1984
1956
<1980
2003
1990
1983
1996
1986
1959
1990
1991
1994
1990
1970
1953
2010
1970
1992
1976
1991
1977
1975
2006
2007
1949
1957
1956
1942
1952
1987
1962
1947
1957
1953
1962
1980
1973
1981
1985
1996
1979
1998
1995
Old
1999
Classification
Gastrointestinal
Analgesic
Analgesic
Respiratory
Gastrointestinal
Endocrine
Antineoplastic
Cardiovascular
Antimicrobial
Respiratory
CNS
Cardiovascular
Analgesic
Antimicrobial
Antimicrobial
CNS
Analgesic
Endocrine
CNS
Antimicrobial
Gastrointestinal
Respiratory
CNS
CNS
Gastrointestinal
Antimicrobial
Antineoplastic
Respiratory
Gastrointestinal
Analgesic
CNS
Respiratory
CNS
Substance abuse agent
CNS
Respiratory
CNS
Gastrointestinal
Cardiovascular
Antimicrobial
CNS
Endocrine
Cardiovascular
CNS
Cardiovascular
Analgesic
Immunomodulatory
No
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
Ingredient
Nabilone
Nabumetone*
Nadolol
Nalmefene
Naloxone
Naltrexone
Naratriptan
Nateglinide
Nebivolol*
Neomycin
Nicardipine
Nicotine
Nilotinib*
Nimodipine
Nisoldipine
Nitazoxanide
Nitroprusside
Nystatin
Ofatumumab*
Olmesartan
Omalizumab
Orphenadrine
Oseltamivir
Oxazepam
Oxybutynin
Oxycodone
Oxytetracycline*
Paclitaxel*
Palonosetron
Pamidronate
Panitumumab
Pegaptanib
Penbutolol
Pentazocine
Pergolide
Perindopril
Phentermine
Phenyltoloxamine
Pimozide
Pindolol
Piperacillin*
Pirbuterol
Polythiazide
Posaconazole*
Pramipexole
Pramlintide
Praziquantel
Year
1985
1991
1979
1995
1971
2006
1976
2004
2000
1970
1988
OTC
2007
1998
1995
2004
1981
1971
2009
2002
2003
1959
1999
1965
1975
1991
<1960
1992
2003
1991
2006
2004
1987
1967
1988
1993
1983
Old
1984
1982
1981
1986
1961
2006
1997
2005
1982
Classification
Gastrointestinal
Analgesic
Cardiovascular
Substance abuse agent
Substance abuse agent
Substance abuse agent
CNS
Endocrine
Cardiovascular
Antimicrobial
Cardiovascular
Substance abuse agent
Antineoplastic
Cardiovascular
Cardiovascular
Antimicrobial
Cardiovascular
Antimicrobial
Antineoplastic
Cardiovascular
Respiratory
CNS
Antimicrobial
CNS
Urologic
Analgesic
Antimicrobial
Antineoplastic
Gastrointestinal
Endocrine
Antineoplastic
Ophthalmologic
Cardiovascular
Analgesic
CNS
Cardiovascular
Weight loss agent
Respiratory
CNS
Cardiovascular
Antimicrobial
Respiratory
Cardiovascular
Antimicrobial
CNS
Endocrine
Antimicrobial
No
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
269
269
270
271
272
273
274
275
276
277
278
279
280
281
282
Prazosin
Primaquine*
Primidone*
Probenecid
Proguanil*
Promazine*
Promethazine
Propantheline
Propranolol
Protriptyline*
Pyrantel
Quazepam
Quinapril
Ramelteon
Ranibizumab
Rasagiline*
Remifentanil
Reserpine
Ribavirin
Rifapentine*
Rifaximin
Rilonacept
Rimantadine
Risedronate*
Rizatriptan
Salbutamol
Salmeterol
Saxagliptin*
Scopolamine
Secobarbital
Selegiline*
Silodosin
Solifenacin
Sotalol
Succimer
Sufentanil
Sulbactam
Sumatriptan
Tadalafil
Tazobactam
Tegaserod
Telbivudine
Telmisartan
Temazepam
Temsirolimus
Teniposide*
Tenofovir
Ingredient
Year
1976
1952
1954
1951
2000
1957
1957
1953
1967
1967
Old
1985
1991
2005
2006
2006
1996
1955
1985
1998
2004
2010
1993
1998
2007
1981
1997
2009
1979
1950
2006
2007
2004
1992
1991
1984
1986
1997
2003
1993
2002
2006
1998
1981
2007
1992
2001
Classification
Cardiovascular
Antimicrobial
CNS
Rheumatologic
Antimicrobial
CNS
Gastrointestinal
Gastrointestinal
Cardiovascular
CNS
Antimicrobial
CNS
Cardiovascular
CNS
Ophthalmologic
CNS
Analgesic
Cardiovascular
Antimicrobial
Antimicrobial
CNS
Immunomodulatory
Antimicrobial
Endocrine
CNS
Respiratory
Respiratory
Endocrine
Gastrointestinal
CNS
CNS
Urologic
Urologic
Cardiovascular
Toxicology
Analgesic
Antimicrobial
CNS
Urologic
Antimicrobial
Gastrointestinal
Antimicrobial
Cardiovascular
CNS
Antineoplastic
Antineoplastic
Antimicrobial
No
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
Ingredient
Terazosin
Theophylline
Thiopental
Thyroid extract
Tiagabine
Ticarcillin*
Tigecycline*
Timolol
Tinidazole
Tinzaparin*
Tiotropium
Tipranavir*
Tolbutamide*
Tolterodine
Topotecan*
Torsemide
Tramadol
Trandolapril
Triazolam*
Trientine
Trifluoperazine*
Trihexyphenidyl*
Triiodothyronine*
Trimethobenzamide
Triprolidine
Trospium
Vardenafil
Vinblastine*
Vinorelbine
Zalcitabine
Zaleplon
Zanamivir
Zoledronic acid
Zolmitriptan*
Zolpidem
Year
1987
1982
<1980
<1960
1997
2005
2005
1995
2004
2000
2004
2005
1961
1998
2007
1993
1995
1996
1982
1985
1959
1949
1956
1974
<1980
2004
2003
1965
1994
1992
1999
1999
2001
1997
1992
Classification
Urologic
Respiratory
CNS
Endocrine
CNS
Antimicrobial
Antimicrobial
Cardiovascular
Antimicrobial
Hematologic
Respiratory
Antimicrobial
Endocrine
Urologic
Antineoplastic
Cardiovascular
Analgesic
Cardiovascular
CNS
Toxicology
CNS
CNS
Endocrine
Gastrointestinal
Respiratory
Urologic
Urologic
Antineoplastic
Antineoplastic
Antimicrobial
CNS
Antimicrobial
Endocrine
CNS
CNS
*These agents have been suspected of having hepatotoxicity or were implicated in published cases
that did not meet the criteria of being possibly causalitive using the RUCAM method.