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Ebola Virus Disease: what you should know and how to manage the risks This leaflet has been put together to provide background information on Ebola Virus Disease (EVD). This briefing material has been produced for those who work in healthcare professions, the media, those with responsibility for giving guidance to the public, and others who are looking for some background understanding of issues and risks related to Ebola. It provides information on symptoms, transmission and how to manage the risk of infection, with links to further information and tools. Key facts Ebola Virus Disease (EVD), formerly known as Ebola haemorrhagic fever, is a severe, often fatal illness in humans with a death rate of up to 90%. EVD outbreaks occur mostly in villages in Central and West Africa, near tropical rainforests. Transmission of the Ebola virus is primarily through direct contact with bodily fluids of an infected individual or through exposure to objects like needles that have been contaminated. Ebola becomes contagious only when symptoms appear in infected people. You cannot catch it from individuals without symptoms Symptoms of EBV include: fever, headache, joint and muscle aches, weakness, diarrhea, vomiting, stomach pain, lack of appetite and abnormal bleeding. Severely ill patients require intensive supportive care and health workers or those in charge of their care need to take strict precautions to prevent spread of the disease Symptoms may appear anytime from two to 21 days after exposure to the virus; most commonly, symptoms appear between eight and ten days after exposure to the virus. Ebola is not transmitted from contaminated food or water. No licensed specific treatment or vaccine is available for use in people or animals. Why are we concerned about Ebola? In March 2014 a new outbreak of EVD was reported in Liberia and New Guinea. The disease has continued to spread and has now reached several surrounding states. A number of health workers have been infected and some have been transported back to the United States for treatment. EVD is a serious, often fatal disease and, if unchecked, will continue to spread within the affected countries as well as across borders. This outbreak is now the longest in history and on the 8th of August 2014 the WHO declared the outbreak an international public health emergency. The main countries affected by the disease lack adequate resources to manage the situation and the WHO has called on the international community for help. Although their advice is that "there should be no general ban on international travel or trade," it issued a long list of recommendations on travel and contacts. This includes for all travellers leaving the affected countries to be screened for fever, and no corpses to be transported across borders. The Centre for Disease Control in Atlanta has issued a level 3 travel alert advising people to avoid unnecessary travel to the region. The president of Sierra Leone has ordered the quarantine of affected neighbourhoods and house to house searches for people who might have been exposed to the virus. Reports like this can be very confusing to the general public, who have to make sense of the infection risks to themselves and their families, and who will be alarmed by reports of the scary symptoms and deathly potential of this infection. In recent years they have had to deal with threats from pandemics like ‘Swine Flu’ and stories from newly emerging viruses like SARS. Global travel has increased the chances of diseases spreading across borders and continents, and people are justifiably concerned and need guidance on the real risks. Although the threat of EVD in the affected countries is real and substantial, the risk in currently unaffected countries is very low and should be kept in proportion. Ebola transmission requires close contact with body fluids from infected persons, and the risk to people visiting friends and relatives in affected countries is considered low. What is Ebola Virus Disease? Ebola Virus Disease (which used to be known by the name Ebola haemorrhagic fever), is a severe illness in humans caused by Ebola virus. The virus causes fever, vomiting and diarrhoea and sometimes internal bleeding and is fatal in up to 90% of cases. It first appeared in 1976 in a village in what is now the Democratic Republic of Congo near the Ebola River, which is how it received its name. EVD outbreaks occur primarily in remote villages in Central and West Africa near tropical rainforests. Ebola virus is part of the family of Filoviridae, genus Ebolavirus. There are five identified subspecies of Ebolavirus. Four of the five have caused disease in humans: Ebola virus (Zaire ebolavirus); Sudan virus (Sudan ebolavirus); Taï Forest virus (Taï Forest ebolavirus, formerly Côte d’Ivoire ebolavirus); and Bundibugyo virus (Bundibugyo ebolavirus). The fifth, Reston virus (Reston ebolavirus), has caused disease in nonhuman primates, but not in humans. The natural reservoir of Ebola virus is thought to be fruit bats of the Pteropodidae family. The virus was introduced to humans through close contact with the organs, blood, and other bodily fluids of infected animals, such as chimpanzees, gorillas, fruit bats and monkeys. What are the symptoms of Ebola Virus Disease? Symptoms of Ebola include fever, headache, joint and muscle aches, weakness, diarrhea, vomiting, stomach pain, lack of appetite and abnormal bleeding. These may appear any time from 2 to 21 days after exposure, but 8-10 days is the most Page 2/6 common. Those who die have usually not developed a significant immune response, but the reasons why some people recover and others don’t are not well understood. There is no vaccine and no known cure for the disease. Although a highly experimental monoclonal antibody, ‘ZMapp’, is showing promising results in reversing the course of the disease in animals, the recent report of a ‘miracle’ cure of a health worker with the antibody ZMAPP is incidental and there have been no published results of human trials. How is the virus transmitted? The virus is transmitted by close contact with someone who is infected. It is assumed that infection occurs by inhaling infected droplets (mucous and other body fluids) from an infected person, or by touching the mouth with contaminated hands. This is different from viral infections like influenza and colds which can be transmitted over significant distances through droplet and aerosol transmission. It is assumed that contamination of hands can occur through exposure to contaminated objects like needles, clothing and other surfaces in close contact with the patient. Public health England advise that infection can also occur if broken skin or mucous membranes of a healthy person come into contact with environments that have become contaminated with an Ebola patient’s infectious fluids such as soiled clothing, bed linen, or used needles. Public Health England also advise that infection generally does not occur through routine, social contact (such as shaking hands) with asymptomatic individuals. People most at risk are health workers or the family caring for an infected person. This is because the more often a person is in contact with an infected person or infected material from that person, the greater the risk. The disease can spread quickly within health care settings when hospital staff are not wearing protective equipment or fail to observe strict hygiene protocols. The first infection in humans is thought to have happened through exposure to infected animals. Who is at risk and how can we contain the spread? The likelihood of contracting any viral hemorrhagic fever (VHF), including Ebola is considered extremely low unless there has been travel to the affected area and direct contact with the blood or body fluids (e.g., saliva, urine) of symptomatic infected persons or animals, or objects that have been contaminated with body fluids. During outbreaks of EVD, those at highest risk of infection are people in close and frequent contact with the patient. This includes health workers and the family and friends of an infected person. This is different from viral infections like influenza and colds which can be transmitted over significant distances through droplet and aerosol transmission. For anyone who cares for an Ebola-infected individual should observe strict precautions as outlined by the WHO or other relevant Public Health bodies like Public Health England. This includes wearing protective clothing such as face masks, gowns and gloves and using disposable equipment wherever possible. Page 3/6 It is not always possible to identify patients with EBV early because initial symptoms such as a fever and a sore throat may be non-specific. For this reason, it is important that health-care workers in countries with suspected or actual Ebola outbreaks apply standard precautions consistently with all patients – regardless of their diagnosis – in all work practices at all times. For healthcare workers these include basic hand hygiene, respiratory hygiene, the use of personal protective equipment (according to the risk of splashes or other contact with infected materials), safe injection practices and safe burial practices. Advice for non healthcare people (including families of infected people) living in affected areas • As with other infectious illnesses, one of the most important preventive practices is careful and frequent handwashing. Cleaning your hands often, using soap and water (or waterless alcohol-based hand rubs when soap is not available), removes potentially infectious materials from your skin and helps prevent disease transmission. • Avoid close contact with infected persons • Surfaces which can transmit infection include surfaces which have become contaminated with body fluids, including feeding utensils and clothing and bedlinens from patients. Take advice from carers on how to handle and decontaminate these items safely. • Take advice from local carers on safe disposal of body fluids and faecal material. • Avoid contact with ill or dead animals, especially primates. • Do not eat “bushmeat” (wild animals, including primates, sold for consumption as food in local markets). Is there a risk from travelling on a flight with someone with Ebola? You cannot catch Ebola through social contact or by travelling on a plane with someone who is infected, without direct contact with the blood or body fluids of an infected person. This is different from viral infections like influenza and colds which can be transmitted over significant distances through droplet and aerosol transmission. The cause of fever in persons who have travelled in areas where VHF is present is more likely to be a common infectious disease, but such persons should be evaluated by a health-care provider to be sure. If there are cases of Ebola in countries like UK, would we see an outbreak similar to West Africa? While the UK and other countries might see cases of imported Ebola, this is extremely unlikely to result in a large outbreak in the UK. Countries like England have healthcare systems with robust infection control systems and processes and disease control systems that have a proven record of dealing with imported infectious diseases. Page 4/6 What is the advice for travellers? The WHO issued the following guidance for travellers: a. The risk of a tourist or businessman/woman becoming infected with Ebola virus during a visit to the affected areas and developing disease after returning is extremely low, even if the visit included travel to the local areas from which primary cases have been reported. Transmission requires direct contact with blood, secretions, organs or other body fluids of infected living or dead persons or animal, all unlikely exposures for the average traveller. Tourists are in any event advised to avoid all such contacts. b. The risk for travellers visiting friends and relatives in affected countries is similarly low, unless the traveller has direct physical contact with a sick or dead person or animal infected with Ebola virus. In such a case, contact tracing should confirm the exposure and prevent further spread of the disease through monitoring the exposed traveller. c. The risk for fellow travellers or patient travellers: there is a possibility that a person who had been exposed to Ebola virus and developed symptoms may board a commercial flight, or other mode of transport, without informing the transport company of his status. It is highly likely that such patients would seek immediate medical attention upon arrival, especially if well informed, and then should be isolated to prevent further transmission. Although the risk to fellow travellers in such a situation is very low, contact tracing is recommended in such circumstances. d. There is a risk for healthcare workers and volunteers, especially if involved in caring for EVD patients. However, if the recommended level of precaution for such settings is implemented, transmission of the disease should be prevented. The risk level can be considered very low to low unless these precautions are not followed, e.g. no personal protective equipment, needle stick injury etc. References • World health Organisation Interim Infection Control Recommendations for Care of Patients with Suspected or Confirmed Filovirus (Ebola, Marburg) Haemorrhagic Fever. March 2008 http://www.who.int/csr/bioriskreduction/filovirus_infection_control/en/ • NHS choices Ebola virus disease http://www.nhs.uk/conditions/ebolavirus/Pages/Ebola-virus.aspx • Public Health England. Guidance: Ebola virus disease: risk assessment of outbreak in West Africa July 2014 https://www.gov.uk/government/publications/ebola-virus-disease-risk-assessmentof-outbreak-in-west-africa • Public health EnglandEbola virus disease: information for humanitarian aid workers. https://www.gov.uk/government/publications/ebola-virus-diseaseinformation-for-humanitarian-aid-workers • CDC Ebola Hemorrhagic Fever - Interim Guidance for Humanitarian Workers Jan 2014 www.cdc.gov/vhf/abroad/humanitarian-workers.html IFH Guidelines and Training Resources on Home Hygiene Page 5/6 Guidelines for prevention of infection and cross infection the domestic environment. International Scientific Forum on Home Hygiene. Available from: http://www.ifh-homehygiene.com/best-practice-care-guideline/guidelinesprevention-infection-and-cross-infection-domestic Guidelines for prevention of infection and cross infection the domestic environment: focus on issues in developing countries. International Scientific Forum on Home Hygiene. Available from: http://www.ifh-homehygiene.org/bestpractice-care-guideline/guidelines-prevention-infection-and-cross-infectiondomestic-0 Recommendations for suitable procedure for use in the domestic environment (2001). International Scientific Forum on Home Hygiene. http://www.ifhhomehygiene.org/best-practice-care-guideline/recommendations-suitableprocedure-use-domestic-environment-2001 Home hygiene - prevention of infection at home: a training resource for carers and their trainers. (2003) International Scientific Forum on Home Hygiene. Available from: http://www.ifh-homehygiene.com/best-practice-training/homehygiene-%E2%80%93-prevention-infection-home-training-resource-carers-andtheir Home Hygiene in Developing Countries: Prevention of Infection in the Home and Peridomestic Setting. A training resource for teachers and community health professionals in developing countries. International Scientific Forum on Home Hygiene. Available from: www.ifh-homehygiene.org/best-practice-training/homehygiene-developing-countries-prevention-infection-home-and-peri-domestic. (Also available in Russian, Urdu and Bengali) This fact sheet was last updated in 2014 Page 6/6