Download Signal transduction in plants

Signal transduction in plants
…introduction…
Michael Wrzaczek
Dept of Biosciences, Plant Biology
Viikki Plant Science Centre (ViPS)
University of Helsinki, Finland
Helsinki, August 18th, 2016
Signal transduction...
...the process by which information is transferred from the
site(s) of perception to the site(s) of response...
Leyser and Day (2016) Signal transduction. In: Biochemistry and Molecular Biology of Plants
Signal transduction refers to the transmission of a molecular
signal in a form of a chemical modification by recruitment
of protein complexes along a pathway that ultimately triggers
a biochemical event.
http://www.wikipedia.org
Plant cells constantly process external and internal information
Plant cells monitor a continuous, complex stream of information
Signal transduction...
• Within cells – intracellular
• Anterograde and retrograde signaling
Stimulus
Mitochondria
Chloroplasts
Vacuole
Nucleus
Cytosol
Signal transduction...
• Within cells – intracellular, but external stimulus
Stimulus
Mitochondria
Chloroplasts
Vacuole
Nucleus
Cytosol
Signal transduction...
• Between cells – intercellular
o Extracellular
o Symplastic
• Between cells and environment
Stimulus
Spread
Signal containment
Difficult to separate inter- and intracellular signaling
Sevilem et al. (2013) Cell Adhesion & Migration 7: 27-32
Stahl & Faulkner (2016) Trends Plant Sci 21: 450-459
Signal transduction integrates development, photosynthesis
and environmental responses
Allahverdiyeva et al. (2015) New Phytologist 208(3): 647-655.
Signal transduction integrates development, photosynthesis
and environmental responses
Allahverdiyeva et al. (2015) New Phytologist 208(3): 647-655.
Few, if any, discrete signal transduction pathways exist in plants
Interactions between pathways allow signal integration
Thursday August 18
09.00
Michael Wrzaczek
Introduction to signal transduction
10.00
Steven Spoel
Transcription dynamics in plant immunity (Teaching lecture)
11.00
Moritz Nowack
The Control of Programmed Cell Death in Plant Development
(Teaching)
13.00
Mikael Brosché
Transcriptional regulation - Negative regulation, more important than
positive regulation?
14.00
Kristiina Himanen
Regulated protein degradation in plant signaling
15.00
Michael Wrzaczek
Post-translational modifications in signal transduction
16.00
Sachie Kimura
Apoplastic ROS signaling and calcium
Transcriptional regulation and transcription factors
Lectures by
Steven Spoel
Mikael Brosché
Farnham (2009) Nature Rev Genet 10: 605-616
Programmed
Cell Death
Lecture by
Moritz Nowack
Post-translational modifications of proteins
Lectures by
Kristiina Himanen
Michael Wrzaczek
ROS signaling combines inter- and intracellular signaling
Stimuli (wounding, salinity, cold, heat, high light and flg22)
(e.g. Ca2+)
Lecture by
Modified from:
Miller et al. (2009)Sci Signal 2(84):ra45
Dubiella et al. (2013) PNAS 110(21):8744
Sachie Kimura
Friday August 19
09.30
Moritz Nowack
Things to do Before You Die - The Preparation of Programmed Cell
Death in Plant Development (Research lecture)
10.00
Cezary Waszczak
Redox signaling
11.00
Steven Spoel
Reversible oxidative protein modifications in plant immunity (Research
lecture)
13.00
Julia Krasensky
Protein Phosphorylation
14.00
Guido Durian
Calcium signaling and kinases
15.00
Paula Mulo
Retrograde signaling
16.00
Kaisa Nieminen
Plant hormone signaling
ROS signaling combines inter- and intracellular signaling
Lectures by
Guido Durian
Cezary Waszczak
Wrzaczek et al. (2013) Curr Opin Plant Biol 16: 575-582
Post-translational modifications of proteins
Lectures by
Julia Krasensky
Guido Durian
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Organelle communication - retrograde signaling
Lecture by
Paula Mulo
Allahverdiyeva et al. (2015) New Phytologist 208(3): 647-655.
Plant hormones
Lecture by
Kaisa Nieminen
Monday August 22
09.30
Duarte Figueiredo
Signaling events during plant reproduction (Teaching)
10.30
Ari-Pekka Mähönen Signal transduction in root development
11.30
Duarte Figueiredo
13.00
Saijaliisa Kangasjärvi Light signaling
14.00
Kirk Overmyer
Balancing tradeoffs between growth and pathogen immunity by
brassinosteroids
15.00
Jarkko Salojärvi
Bioinformatic methods to study signal transduction
Auxin couples fertilization to endosperm development (Research
lecture)
Root development
Lecture by
Ari Pekka Mähönen
Mähönen et al. (2014) Nature 515: 125-129
Signaling in plant reproduction
Lecture by
Duarte Figueiredo
Figueiredo & Köhler (2016) Curr Opin Plant Biol 29: 16–20
Light signaling
Lecture by
Saijaliisa Kangasjärvi
Allahverdiyeva et al. (2015) New Phytologist 208(3): 647-655.
Growth and pathogens
Lecture by
Kirk Overmyer
De Bruyne et al. (2014) Mol Plant 7(6): 943-959
Bioinformatics to study signal transduction
Lecture by
Jarkko Salojärvi
Tuesday August 23
09.00
Student lectures
Aleksia Vaattovaara (Mentor Julia Krasensky) S-locus kinases and peptides
Chang Su (Mentor AP Mähönen) Auxin-mediated lateral root formation in Arabidopsis
Delfia Isabel Marcenaro Rodrigues (Mentor Kirk Overmyer) Chitin?
Eeva Marttinen (Mentor Kirk Overmyer) Chitin?
Kai Wang (Mentor Cezary Waszczak) Methods for identification of cysteine oxidative PTMs
Kerri Hunter (Mentor Mikael Brosché) Stomatal development and signaling
Lingping Zhu (Mentor AP Mähönen) Signaling in reproduction
Mukrimin Mukrimim (?)
Nashmin Ebrahimi (Mentor Michael Wrzaczek) ROS/RNS
Omid Mohammadi (?)
Riikka Mäkikä (?)
Sitaram Rajaraman (Mentor Kaisa Nieminen) Hormones
Yan Yan (Mentor Saijaliisa Kangasjärvi) Light signaling
Yusuf Khan (Mentor Jarkko Salojärvi) Bioinformatics
Presentations
Length: 15 minutes (plus 5 minutes for discussion)
Can be supported by powerpoint slides
Evaluation criteria:
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knowledge of the selected topic
connection to signal transduction
if relevant connection to topics presented in the course
ability to answer questions (from teachers and students)