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Organizing Principles of Cell Signalling
During Development
modification
Protein
functional protein
interacting with other proteins
RNA
Gilbert e11 ch 4 pp 115-142,
E10 ch 3 pp84-99: Cell to cell communication
TGF b superfamily signaling
Wnt signaling, MAPK pathways
DNA
BACTERIAL SIGNAL TRANSDUCTION
Nitrogen
phosphate
osmolarity
Signal
N
Sensor
ATP
C
ADP
PO4 3-
Regulator
N
C
Polymerase
MAIN COMPONENTS OF GROWTH FACTOR SIGNALLING
PATHWAYS TO THE NUCLEUS
SIGNAL
(GF)
SENSOR
(RTK)
(Kinase Cascade)
Activation of
transcription of genes
that respond to the
stimulus
P
REGULATOR
(Transcription
Factor)
Relationships among members of the TGF b superfamily cytokines
The Smad pathway activated by
TGF-β superfamily ligands
Extracellular processing of TGF b ligands
Canonical Wnt signaling
FGF8 expression in the 3-day
chick embryo
Figure 3.19 Structure and function of a receptor tyrosine kinase
Figure 3.21 The widely used RTK signal transduction pathway
Even skipped (Eve) a pair rule gene
Model of major postulated interactions in
the patterning of the somite
Signaling between NT, Nc and somite