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Organizing Principles of Cell Signalling During Development modification Protein functional protein interacting with other proteins RNA Gilbert e11 ch 4 pp 115-142, E10 ch 3 pp84-99: Cell to cell communication TGF b superfamily signaling Wnt signaling, MAPK pathways DNA BACTERIAL SIGNAL TRANSDUCTION Nitrogen phosphate osmolarity Signal N Sensor ATP C ADP PO4 3- Regulator N C Polymerase MAIN COMPONENTS OF GROWTH FACTOR SIGNALLING PATHWAYS TO THE NUCLEUS SIGNAL (GF) SENSOR (RTK) (Kinase Cascade) Activation of transcription of genes that respond to the stimulus P REGULATOR (Transcription Factor) Relationships among members of the TGF b superfamily cytokines The Smad pathway activated by TGF-β superfamily ligands Extracellular processing of TGF b ligands Canonical Wnt signaling FGF8 expression in the 3-day chick embryo Figure 3.19 Structure and function of a receptor tyrosine kinase Figure 3.21 The widely used RTK signal transduction pathway Even skipped (Eve) a pair rule gene Model of major postulated interactions in the patterning of the somite Signaling between NT, Nc and somite