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Size-controlled preparation of nanosoy for potential biomedical applications ISAAC STOKES 3/9/17 Soy Characteristics • • • • • Soy Protein Isolate Drug Delivery Wound Dressings Tissue Engineering Protein vs Polymers • • • Non-Immungenic Non-Alergenic Charges Allow Flexibility Nanosoy Nanoprecipitation/Solvent Displacement Ouzo Effect ◦ Solute dissolved in organic solvent ◦ Gradually mixed into aqueous ◦ Stabilizes solute SPI Solution (pH 11) High pH raises electrostatic repulsion Separated By Centrifugation Tested Parameters Temperature Dependence ◦ 30-70°C Solution pH ◦ 3-11 Solvent/Non Solvent Ratio ◦ 1:10-1:30 Surfactant Type Spherical Shape Nearly Monodispersed 5-15nm In Diameter Acidic Conditions Lead To Flocculation ◦ Electrostatic Conditions Altered ◦ Limits Protein-Protein Interactions Higher Temperature Increased Diameter Greater Ratio Lead To Larger Particles Tween 80 (surfactant) Made Largest Particles Stability and Size Ciproflaxcin Augmented Nanosoy Added to Soy then Nanoprecipitated Drug Released by Diffusion Burst then Sustained Release Ciproflaxcin References Singh, Surabhi, and Bhuvanesh Gupta. "Size-controlled preparation of nanosoy for potential biomedical applications." Polymer International 65.12 (2016): 1373-381. Web. 33 Mar. 2017 Beck-Broichsitter, Moritz, Erik Rytting, Tobias Lebhardt, Xiaoying Wang, and Thomas Kissel. "Preparation of nanoparticles by solvent displacement for drug delivery: A shift in the “ouzo region” upon drug loading." European Journal of Pharmaceutical Sciences 41.2 (2010): 244-53. Web. 7 Mar. 2017. Ding, Xuzhe, and Ping Yao. "Soy Protein/Soy Polysaccharide Complex Nanogels: Folic Acid Loading, Protection, and Controlled Delivery." Langmuir 29.27 (2013): 8636-644. Web. 7 Mar. 2017.
