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Transcript
ANTIPSYCHOTICS B Y A L A I N A DA R B Y Which of the following is an example of a negative symptom of psychosis? a. Crawling sensation b.Delusion of grandeur c. Lack of social interest d.Waxy flexibility Which of the following would be an example of disorganized or catatonic behavior? a. Tangentiality of speech b.Inappropriate affect c. Feeling of persecution d.Hearing voices Which of the following is evidence that contradicts with the dopamine hypothesis? a. Dopamine underactivity in the prefrontal cortex causes negative symptoms b.Time delay in reduction of psychotic symptoms after treatment c. Anti-schizophrenic drugs block dopamine receptors d.Amphetamine can induce psychosis Which of the following drugs is used to support the glutamate hypothesis of schizophrenia? a. Amphetamine b.PCP c. Strychnine d.Cocaine Why would targeting mGlu receptors not be a good method of preventing psychosis? a. They can modulate glutamate release b.They can modulate dopamine release c. There are 8 subtypes of the receptors d.Agonism can induce seizures Typical antipsychotics have affinity for all of the following receptors except… a. Muscarinic b.Alpha-adrenergic c. Histamine d.Serotonin e.Dopamine Which of the following groups of typical antipsychotics have the highest potency? a. Phenothiazines with an aliphatic side chain b.Phenothiazines with a piperidine ring in the side chain c. Thioxanthenes d.Phenothiazines with a piperazine group in the side chain Which of the following groups of typical antipsychotics have the lowest potency? a. Phenothiazines with an aliphatic side chain b.Phenothiazines with a piperidine ring in the side chain c. Thioxanthenes d.Phenothiazines with a piperazine group in the side chain Which of the following is true of antipsychotics? a. High potency typicals have a reduced risk of EPS b.Low potency typicals are less efficacious than higher potency antipsychotics c. Atypical antipsychotics have increased affinity for D2 as compared to typical antipsychotics d.Increased anticholinergic activity reduces the risk of EPS Which of the following atypical antipsychotics has an active metabolite that is also marketed? a. Molindone b.Risperidone c. Ziprasidone d.Lurasidone Which of the following antipsychotics reduces the incidence of side effects by only partially antagonizing D2 receptors? a. Aripiprazole b.Asenapine c. Clozapine d.Lurasidone Which of the following has affinity for alpha adrenergic and histamine receptors but low affinity for muscarinic receptors? a. Aripiprazole b.Asenapine c. Clozapine d.Lurasidone Which of the following has a low affinity for muscarinic and histamine receptors but still maintains affinity for alpha adrenergic receptors? a. Iloperidone b.Resperidone c. Molindone d.Lurasidone Which of the following is considered a low potency antipsychotic? a. Fluphenazine b.Loxapine c. Thioridazine d.Pimozide Which of the following is not an atypical antipsychotic? a. Risperidone b.Olanzepine c. Loxapine d.Asenapine Which receptor do all atypical antipsychotics target? a. 5-HT1 b.5-HT2 c. Alpha adrenergic d.Histamine e.Muscarinic Which of the following would have the least side effects but still has a risk of EPS? a. Lurasidone b.Iloperidone c. Asenapine d.Rispiridone The term “neuroleptic syndrome” is used to describe the therapeutic effects of antipsychotics that can be seen in animals. Which of the following is not one of these effects? a. Supression of spontaneous movements b.Increased initiative and interest in environment c. Decreased manifestations of emotion d.Disappearance of psychotic symptoms Where are the antipsychotic effects thought to occur? a. Cerebral cortex b.Basal ganglia c. Limbic system d.Brainstem Which of the following increases prolactin secretion? a. Lurasidone b.Iloperidone c. Asenapine d.Rispiridone Which of the following antipsychotics is most likely to lower seizure thresholds? a. Olanzapine b.Rispiridone c. Ziprasidone d.Asenapine What portion of the brain is thought to be associated with the EPS effects? a. Cerebral cortex b.Basal ganglia c. Limbic system d.Brainstem Scott has a family history type II diabetes. With this in mind, which of the following antipsychotic would be preferred? a. Clozapine b.Rispiridone c. Thioridazine d.Olanzepine Prolonged QT is most likely to be a problem in which of the following classes of antipsychotics? a. Low potency typicals b.Potent typicals c. Low potency atypicals d.Potent atypicals Which of the following is not true of the pharmacokinetics of antipsychotics? a. Highly protein bound b.Accumulates in high blood supply tissues c. Crosses placental barrier and enters breast milk d.Good oral absorption Which of the following is true of antipsychotics? a. Low therapeutic index b.Abrupt stoppage causes difficulty sleeping c. Addicting d.Most metabolites are active Which of the following is a neurological side effect associated with prolonged use of antipsychotics? a. Acute dystonia b.Neueroleptic malignant syndrome c. Tardive dyskinesia d.Akathesia Which of the following is benztropine not one of the primary methods of treatment? a. Acute dystonia b.Akathesia c. Parkinsonian syndrome d.Neuroleptic malignant syndrome Which of the following is not a risk of taking antipsychotics? a. Type II diabetes b.Weight gain c. Jaundice d.Insomnia Which of the following is most likely to cause blood dyscrasis? a. Clozapine b.Chlorpromazine c. Quentiapine d.Rispiridone Which of the following is most likely to cause drug interactions? a. Thioridazine b.Haloperidol c. Pimozide d.Lurasidone What would not be a strategy for treating psychosis? a. Choose based on side effects b.Target specific symptoms c. Use only in schizophrenia d.Trial and error in drug choice Which would not be a use of antipsychotics? a. Major depression b.Parkinson’s disease c. Nausea and vomiting d.Alcoholic hallucinations