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Annotated Bibliography 1. Corr, Stuart J., et al. "A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia." PLoS ONE 10.8 (2015). Academic OneFile. Web. 15 Nov. 2015. This article talks about Kanzius Research, and how exchanges of high-frequency radiowaves with tissues and nanomaterials in biological tissues are presently being examined as a beneficial platform for non-invasive cancer hyperthermia therapy. This article talks about publications that have validated anti-tumor effects subsequent to non-invasive radio frequency waves. A custom portable radio frequency system has been designed and engineered, and it can be retrofitted simply to a high-resolution Nikon A1R+ intravital microscopy system permitting real-time in vivo image acquisition of radio frequency-induced biological effects such as enhanced fluorescent tracer perfusion into tumors and high-temperature vessel deformation Future work with the new imaging platform include detailed analysis of radio frequency mediated biological effects, including vascular permeability, blood flow, tissue alterations, nanoparticle and drug accumulation, tissue penetration, and cellular migration events. This article included information that I can use in my paper to discuss benefits of investing into this research and the future possibilities of this research. It talks Kanzius Research and how it is being furthered with the creation of a new portable radio frequency system. I found this article on the FSW library electronic database. Research reported in this publication was supported by the NIH Physical Science in Oncology Program. (200 words) 2. "Cure for Cancer." Cure for Cancer. N.p., n.d. Web. 16 Nov. 2015. <http://www.free-bullion- investment-guide.com/cure-for-cancer.html>. This article talks about Kanzius Research which is a type of radiotherapy, which is being used by many different research groups, and was created by John Kanzius. Radiotherapy is a regularly used method of research that destroys Cancer Cells using Gold Nano-Particles and incorporates the use of radio waves. The way the Kanzius method worked was by injecting Gold Nano-particles with antibodies attached, into the blood stream of a subject with cancer. As soon as the Gold Nano-Particles collected on the tumor or tumors, the subject is then placed between two radio wave machines, for anywhere from a few minutes up to an hour. The Gold Nanoparticles are heated by the radio waves, destroying the cancerous cells, thus leaving the rest of the healthy tissues in the body unaffected. Currently, Gold Nano-Particle research is showing that subjects (which currently is only animal subjects) who have been treated with radio-waves, lasers, targeted-drugs and infrared light, etc., don’t display the harmful side effects that are caused by radiation and chemotherapy. This article included information that I can use in my paper. It talks Kanzius Research and gives a lot of background information as well as some benefits to supporting the research. This article was published in a free investment guide, Free Bullion Investment Guide. Although their disclaimer says all information provided has been researched and every effort has been made to insure that the information is accurate and up to date, it also states that all articles are strictly for informational purposes only. (251 words) 3. Hayasaki, Erika. "Kanzius Cancer Machine Gets Its First Human Trial." Newsweek.com. N.p., n.d. Web. 15 Nov. 2015 This article talks how the Noninvasive Radiowave Cancer Device that evolved from this thought experiment by John Kanzius eventually made the pages of many respected medical journals and attracted the funding and backing of leading cancer researchers, as well as a Nobel Prize winner. After Kanzius death his research was continued by an oncologist named Dr. Steven A. Curley. In May of this year, Dr. Curley filed protocols with the Italian Ministry of Health to do human trials with the radio wave machine on subjects diagnosed with pancreatic and liver cancer. If this is approved, human clinical trials will begin in Naples, Italy in spring of 2016. Although the original Kanzius machine got the job done, Curley will use a much different looking machine for clinical trials. They are currently on the sixth-generation version of the machine. Curley’s team injected nanoparticles into petri dishes full of human cancer cells, as well as into tumors in mice, rats, rabbits and pigs. Using the Kanzius machine, the team was able to heat the nanoparticles and, as a result, destroy all those cancerous cells. Curley along with 20 researchers with expertise in nanomaterials, radiofrequency, immune function and drug delivery functions are working in his lab at the Dan L. Duncan Cancer Center at Baylor College of Medicine in Houston, Texas and deeply believe in the potential of this Kanzius’ work. This article included information that I can use in my paper to discuss some background information but also discuss the benefits of investing into this research and the future possibilities of this research. I found this article doing a google search. This article is published in Newsweek, which is a reputable magazine and has been providing high quality journalism for 80 years. (289 words) 4. "Tasia Valenza Voice's Kanzius Cancer Research Foundation Spread the Wave." YouTube. YouTube, n.d. Web. 15 Nov. 2015. This video is narrated by an American voice actress named Tasia Valenza and speaks about cancer and how everyone is somehow touched by cancer. She also discusses how the survival rates are very low in the United States, less than 50% overall over 5 years. She discusses how you have to endure many painful and life draining therapies. It also tells about John Kanzius and his theory and how his machine has continued to produce stunning results in a controlled laboratory setting. They give an overview of how this theory and machine work to destroy cancer cells, and how this procedure is non-invasive other than a small injection. The Kanzius Research has now since gotten funding and they are now in phase 2 human trials. Extensive research is being conducted at the University of Texas M.D. Cancer Center, University of Pittsburg Medical Center, and University of California-Davis.. I chose this video because it gave some good statistics on cancer and survival rates, it also gives background information about the Kanzius Research and how the machine works to treat cancer, as well as the benefits associated with using this treatment. The video was on Youtube and was published by Kanzius Cancer Research Foundation. (202 words) 5. Templeton, David. "Kanzius Radiofrequency Cancer Treatment Headed to Clinical Trials." McClatchy – Tribune Business News Sep 15 2015. ProQuest. Web. 15 Nov. 2015 . This article talks about the possibility of human clinic trials as soon as summer of 2016 in Italy for the radiofrequency cancer treatment invented by John Kanzius. The hopes are that if the trials are successful in Italy, the FDA will approve clinical trials in the United States. Dr. Curley was recently awarded a 3 year 9 million dollar grant from NeoTherma Oncology, this is a huge step forward for this research. Dr. Curley and team are hoping to show that this non-invasive technology can alter the architecture of the cancer-cell in a way that makes them weakier to existing cancer treatments. The article also talks about previous studies done by the Curley team, such as the impairment of function of the mitochondria or powerhouse of the cancer cells by using the radiofrequency treatment. According to this article a big investment group that formed NeoTherma Oncology and is investing in and backing the push into clinical trials. This article has really good information on the benefits of this Kanzius radiofrequency research and the future of the research and where it is heading. This article is published in the McClatchy Tribune Business News, which is a leading provider of news and information that is dedicated to quality journalism. I also found this article on the FSW library electronic database. (218 words) 6. Thompson, Terry. A New Strategy for the War on Cancer Finally! A New Force Is Entering the Fight and Its Success Depends on Us. New York: Morgan James, 2010. Print. This book talks about the severe damage caused to the body by radiation and chemotherapy in treating cancer, and how there has to be a better way to treat. It also talks about the radio wave generator invented by John Kanzius that heats nanoparticles that have been injected into the cells of cancer tumors. It discussed how he himself was suffering from leukemia, a type of cancer, and how seeing the sick children on the cancer ward made him determined to try something to cure cancer. It talked about how he went from building a radio wave machine in his kitchen to turning his garage into a laboratory and investing $200,000 towards experimenting to find the cure. The article also spoke about how he met a professor of oncology, Dr. Steven Curley, while going for cancer treatments and shared with him all the results of his home experiments. Kanzius also caught the attention of a fellow cancer sufferer and Nobel Rick Smalley. It was Smalley who provided nanotubes for Kanzius’ research. John Kanzius has since passed away but his research has been kept alive and continues. According to the article the radio wave treatment for cancer is a very intriguing, but may prove to be ineffective in the human trials. group that formed NeoTherma Oncology and is investing in and backing the push into clinical trials. This book has really good information on the background of Kanzius research and how it all began and ended up where it is now. This is a book with an author that is a former military officer with an academic focus, who lost his wife to a long agonizing battle with cancer. (278 words)