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Efforts Toward Short Term Objectives (up to 3 Years Year-1 Set up a Clinical Trial Platform for CL •Develop Standard Protocol •Set up communication with all sites Select trial sites and prepare for trials •Adapt the standard protocol •Enhance c-GCP through preparation for a specific trial (i.e. establish ERB, DSMB,… •Set up GCP Training Workshops •Set up infrastructure for the trial … Tox studies of selected combinations (if necessary) Immunomodulator Standardize killed parasite vaccine: •Grow in defined medium •Establish potency assay •Develop lot release test Follow Second Generation Vaccine •Develop in collaboration Antiparasitic Year-2 Conduct Phase 1-2 trials of combined drugs Conduct Phase 1-2 trials •Short term + topical •Short term drug + Immuno-modulator (Imiquimod, CpG) •Short term other combination to selected •Short term drug + therapeutic vaccines Year-3 Decision Matrix for Short Term Objectives