Download - Neuromorphometrics, Inc.

Neuromorphometrics, Inc.
1Dept.
of Speech, Language, and Hearing Sciences, Boston Univ., Boston, MA;
2Neuromorphometrics, Inc., Somerville, MA Funded by SBIR grant R43 MH084358 from the National Institute of Mental Health
References for Brain Labeling
Objective
To build a statistically meaningful, MRI-based interactive atlas of the human
cerebral sulci that represents an update and large-scale expansion of the atlas by
Ono and colleagues (“Ono”; Thieme Medical, Stuttgart, 1990).
Probabilistic Atlases
Traditional Atlases
Digital Atlas
The modern atlas has multiple subjects with explicitly defined borders, regions
and surfaces, is stereotaxic, searchable, expandable, and allows interaction
and manipulation in the native space of individual scan.
Surface-Assisted Manual Labeling
Examples of Sulcal Variability
Common Patterns of Cingulate Sulcus:
Common Patterns:
“Double Parallel”
Single, Continuous Segment
Two Segments
Three Segments
Intersects Superior Rostral Sulcus
% Total
48
45
40
13
55
% RH
30
35
40
5
65
%LH
65
55
40
20
45
Manually drawn “parcellation lines” visualized with the white matter surface
highlight sulcal locations and configurations.
2D and 3D Visualization
NeuroMorphoNaut, open-source software developed by Neuromorphometrics,
was used to manually label 20 unique T1 scans from the Open Access Series of
Imaging Studies (OASIS) database. The slice-by-slice manually labeled white
matter is used to generate a highly accurate white matter surface that assists in
the identification of anatomical landmarks.
Cortical Labeling Protocol
Single cingulate (green), formed by a single continuous segment
that intersect the superior rostral sulcus (SROS; blue)
Database of
Labeled Scans
“Double Parallel” with SROS intersection
Database of
Normative Values
Two Segments, No SROS Intersection
Position of the Lateral Orbital Sulcus (LOS) relative to the
Anterior Horizontal Ramus of the Lateral Sulcus (AHLS):
Future Directions
aals
ahls
aocs
cas
ccs
cgs
cis
cos
crs
cs
fms
ftts
anterior ascending ramus of the lateral sulcus
hs Heschl's sulcus
anterior horizontal ramus of the lateral sulcus
ifrs inferior frontal sulcus
ihs interhemispheric sulcus
anterior occipital sulcus
callosal sulcus
iros inferior rostral sulcus
calcarine sulcus
itps intraparietal sulcus
cingulate sulcus
its inferior temporal sulcus
central insular sulcus
lhos lateral H-shaped orbital sulcus
locs lateral occipital sulcus
collateral sulcus
circular insular sulcus
los lateral orbital sulcus
central sulcus
ls lateral sulcus
frontomarginal sulcus
mho medial H-shaped orbital sulcus
first transverse temporal sulcus
olfss olfactory sulcus
ots
pals
phls
pis
pocs
pos
prcs
sbps
sfrs
sros
sts
thos
occipitotemporal sulcus
posterior ascending ramus of the lateral sulcus
posterior horizontal ramus of the lateral sulcus
primary intermediate sulcus
postcentral sulcus
parietooccipital sulcus
precentral sulcus
subparietal sulcus
superior frontal sulcus
superior rostral sulcus
superior temporal sulcus
transverse H-shaped orbital sulcus
49 regions of interest per hemisphere rely on 36 sulci according to the
brainCOLOR labeling Protocol (http://www.braincolor.org/).
•  Label more brains and catalog more sulcal variants
•  Develop interactive atlas software
•  Develop automated means for sulcus identification, variant classification
•  Customized brain classification based on “sulcal signatures”
•  Optimize labeling protocol
Reference
LOS (tan) Medial to AHLS (green) in 35%
of hemispheres (25% in LH, 45% in RH)
LOS Lateral to AHLS in 65% of
hemispheres (55% in RH, 75% in LH)
M. Ono, S. Kubik and C. Abernathey (1990). Atlas of the cerebral sulci. G. Thieme
Verlag, Stuttgart, Germany