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Research Group n. 2 UNIVERSITA’ DEGLI STUDI DI PADOVA Synthesis of Platinum Group Metal Complexes for Homogeneous Catalysis and Biological Applications Synthesis of Hybrid, Fluorinated and Nanocomposite Materials R. Bertani, M. De Nardi, G. Facchin, R.A. Michelin, M. Mozzon, P. Sgarbossa, A. Tassan, E. Ugel, F. Simionato Dipartimento di Ingegneria Industriale, Università di Padova, Via F. Marzolo 9, I-35131 Padova; E-mail: [email protected] • Synthesis of of Pt(II) and Pd(II) complexes as Lewis acids, containing new C-, N- and P- based ligands, to be used in homogeneous catalysis such as epoxidation and isomerization of olefins, hydration of alkynes, Baeyer-Villiger oxidation of ketones and the catalytic formation of C-C and/or C-X (X = heteroatom) bonds, in organic and acqueous medium. • Synthesis and biological activity of Pt(II) and Pd(II)-carbene complexes derived by metalpromoted addition reactions of alcohols, thiols, amines and other protic nucleophiles to coordinated isocyanides. Investigation of the structure/cytostatic activity relationship of the resulting complexes either in vitro and in vivo. • Synthesis and biological activity of Pt(II) complexes derived by metal-promoted addition reactions of alcohols, thiols, amines and other protic nucleophiles to coordinated organonitriles, alkyl cyanamides and cyanoguanidine. Investigation of the structure/cytostatic activity relationship of the resulting complexes either in vitro and in vivo. • Synthesis and characterisation of new phosphazene materials, either trimers and polymers, bearing different functional groups able to coordinate metal centers or nucleophilic moieties in order to prepare supramolecular systems and functionalized metal nanoparticles. • Synthesis of perfluorinated or partially fluorinated organic and organometallic compounds in order to prepare supramolecular arrangements. Study of the physical/chemical properties of multiblocks semifluorinated compounds either as small molecules and gas dissolving agents. • Functionalization of clays to prepare nanocpmposites with advanced properties. • Functionalization of metal and metal oxide nanoparticles and preparation of nanostructured innovative composites via melt blending. • Synthesis of new polymer-based nanostructured membranes containing transition metal complexes via electrospinning, for the catalytic decomposition of volatile organic compounds. Keywords: Platinum group metals, Homogeneous catalysis, Inorganic synthesis, Antitumor activity, Nanocomposites, Fluorinated systems, Phosphazenes, Hybrid materials 1. C. Marzano, S.M. Sbovata, V. Gandin, D. Colavito, E. Del Giudice, R.A. Michelin, A. Venzo, R. Seraglia, F. Benetollo, M. Schiavon, R. Bertani J. Med. Chem. 53 (2010) 6210-6227. 2. R.A. Michelin, P. Sgarbossa, A. Scarso, G. Strukul Coord. Chem. Rev. 254 (2010) 646 – 660. 3. Michelin R., Sgarbossa P, Sbovata SM, Gandin V, C. Marzano, Bertani R (2011). Chemistry and Biological Activity of Platinum Amidine Complexes. ChemMedChem, vol. 6; p. 11721183. 4. Amadio E, Bertoldini M, Scrivanti A, Chessa G, Beghetto V, Matteoli U, Bertani R., A. Dolmella. (2011). Synthesis, crystal structure, solution behavior and catalytic activity of a palladium (II)-allyl complex containing a 2-pyridyl-1,2,3-triazole bidentate ligand. Inorganica Chimica Acta. vol. 370, pp. 388-393. 5. Cavarzan A., Scarso A., Sgarbossa P., Strukul G., Reek Joost N. H. (2011). Supramolecular Control on Chemo- and Regioselectivity via Encapsulation of (NHC)-Au Catalyst within a Hexameric Self-Assembled Host. Journal of The American Chemical Society. vol. 133, pp. 2848-2851. SUPPLEMENTARY MATERIAL Detailed list of the components of the research groups (permanent staff, included graduated students and postdocs) Name Surname Position * Affiliation Roberta Bertani PA University of Padova Marco De Nardi PoD University of Padova Giacomo Facchin RC ISTM-CNR, Padova Rino A. Michelin PO University of Padova Mirto Mozzon PA University of Padova Paolo Sgarbossa RU University of Padova Augusto Tassan T University of Padova Elisabetta Ugel PoD University of Padova Fabio Simionato PoD University of Padova *: PO = full professor; PA = associated professor; RU = university researcher; PhD = graduated student; PoD = postdoctoral fellows; RC = CNR staff; T = technician Apparatus (minimum value 25.000 Euro per item) Type LCQ-Duo ESI-MS Spectrum 100 FT-IR Lambda 19 UV/VIS/NIR AC-200 NMR HRGC/MS TG-DSC Producer Finnigan Thermo Perkin Elmer Perkin Elmer Bruker Carlo Erba TA Instruments Year of acquisition 2009 2007 2007 2001 2002 2001 Technical skills • • • Design and synthesis of functional P-, C- and N- ligands; Design and synthesis of platinum(II) and palladium(II) complexes for catalytic and biological applications; Synthesis of new inorganic or hybrid materials.