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Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. GR‐2010‐ 2317594 NEW GENETIC LESIONS CHARACTERIZING HIGH Piemonte RISK CHRONIC LYMPHOCYTIC LEUKEMIA: CLINICAL AND FUNCTIONAL IMPLICATIONS BIO Oncology 2 ‐ Translational Clinical RF‐2010‐ 2319316 High‐density EEG as a tool for localizing the epileptogenic zone in extratemporal refractory focal epilepsy: a validation study by means of Stereo‐EEG and post‐surgical outcome evaluation CLI RF‐2010‐ 2310438 PROTECTIVE AND DANGEROUS IMMUNE RESPONSES OSPEDALE BAMBINO DURING HIV‐1 INFECTION GESU' RF‐2010‐ 2318372 Novel surface and intracellular targets for tailored nanotechnology‐based drug delivery in colorectal cancer RF‐2010‐ 2306232 Finanz.Richiesto SCORE. 4,5 € 600.000 Brain Disorders and Clinical Neuroscience 5 € 393.000 CLI AIDS and Related Research 5 € 515.000 SDN BIO Oncology 1 ‐ Basic Translational 5,5 € 530.000 Identification and functional validation of microRNA biomarkers in lung cancer ISTITUTO TUMORI MILANO BIO Oncology 2 ‐ Translational Clinical 6 € 396.000 RF‐2010‐ 2307403 Congenital anomalies of the kidney and urinary tract (CAKUT): definition of genetic and structural backgrounds based on high through‐put innovative approaches. GASLINI BIO Digestive, Kidney and Urological Systems 6 € 355.000 RF‐2010‐ 2305199 Autophagy in the immune response against Istituto Superiore di Sanita' Mycobacterium tuberculosis: identification of novel rapamycin‐regulated host targets to improve BCG vaccine immunogenicity. BIO Infectious Diseases and Microbiology 6 € 500.000 GR‐2010‐ 2318367 Biomarkers and functional imaging guided treatment decision making in recurrent prostate cancer. CLI Oncology 2 ‐ Translational Clinical 6 € 470.000 Lombardia Toscana NOTE Pagina 1 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE PROGETTO RF‐2010‐ 2316198 PATHWAYS OF COAGULATION AND PLATELET ACTIVATION IN FLOWING BLOOD: NEW PERSPECTIVES IN THE MANAGEMENT OF ANTITHROMBOTIC THERAPY C.R.O. AVIANO BIO Vascular and Hematology 6,25 € 525.000 GR‐2010‐ 2311329 Dissection of the immune response to human cytomegalovirus glycoprotein complexes: perspective for the development of a candidate subunit vaccine SAN MATTEO BIO Immunology 6,33 € 445.000 RF‐2010‐ 2305605 Mechanisms of aggregation and toxicity of tau protein in Alzheimer's disease IRCCS AOU San Martino‐ IST (Genova) BIO Molecular, Cellular, and Developmental Neuroscience 6,5 € 520.000 RF‐2010‐ 2316010 P2X7 receptor/MMP9 pathway in thrombosis and atherosclerotic plaque destabilization: exploring the possibility to modulate carotid plaque progression SAN RAFFAELE MONTE TABOR BIO Vascular and Hematology 6,5 € 548.800 RF‐2010‐ 2319059 Preparatory, response‐related, outcome‐evaluation and predictive components of attentional orienting in right brain damage: clues for diagnosis and rehabilitation SANTA LUCIA CLI Biobehavioral and Behavioral Processes 6,5 € 400.000 RF‐2010‐ 2309704 Targeting drug resistance in Ovarian Cancer C.R.O. AVIANO BIO Oncology 2 ‐ Translational Clinical 6,5 € 540.000 GR‐2010‐ 2315414 mTOR‐dependent oscillatory metabolic switch controlling self‐immune tolerance SANTA LUCIA BIO Immunology 6,75 € 570.000 RF‐2010‐ 2309790 Pemphigus vulgaris as a paradigm of autoantibody‐ ISTITUTO DERMOPATICO mediated organ‐specific autoimmune disorder: pathophysiology and novel tools for diagnosis and therapy DELL'IMMACOLATA BIO Musculoskeletal, Oral and Skin Sciences 7 € 480.000 RF‐2010‐ 2305526 TArgeted Multistage vector (MSV) for the DIagnosis and Veneto treatment of Solid tumors BIO Bioengineering Sciences and Technologies 7 € 478.000 GR‐2010‐ 2318448 Towards intervertebral disc regeneration: mesenchymal stem/stromal cells with a novel bioactive hydrogel based approach. BIO Musculoskeletal, Oral and Skin Sciences 7 € 550.000 MAGGIORE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE SCORE. NOTE Pagina 2 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2308270 Interleukin‐27 in the control of pediatric acute leukemia cell growth in NOD/SCID/Il2rg‐/‐ mice with human immune system GASLINI BIO Immunology 7 € 520.000 RF‐2010‐ 2316197 HPV INFECTION AND DISEASE IN IMMUNOSUPRESSED MALES AND FEMALES: PREVALENCE ANDVIRO‐IMMUNOLOGICAL DETERMINANTS OF ORGAN DAMAGE IRCCS AOU San Martino‐ IST (Genova) BIO Immunology 7 € 315.000 RF‐2010‐ 2313497 Early detection and treatment of recurrent, ISTITUTO TUMORI chemotherapy‐resistant ovarian cancer stem cells by CPE MILANO peptide complexed superparamagnetic iron oxide nanoparticles (CPE‐SPIONs) BIO Oncology 2 ‐ Translational Clinical 7 € 570.000 RF‐2010‐ 2315888 Dissecting the role of plasmacytoid dendritic cells in the progression of cutaneous melanoma Lombardia BIO Oncology 1 ‐ Basic Translational 7 € 560.000 RF‐2010‐ 2317597 Identification of common biological pathways in Rett patients mutated in MECP2, CDKL5 and FOXG1. Toscana BIO Molecular, Cellular, and Developmental Neuroscience 7 € 470.000 RF‐2010‐ 2318512 Role of influenza virus infection in the etiopathogenesis of diabetes Istituto Zooprofilattico Sperimentale delle Venezie BIO Infectious Diseases and Microbiology 7 € 470.000 RF‐2010‐ 2312580 The ECM molecule MULTIMEIN2 as a potential therapeutic tool to hamper tumor angiogenesis and tumor growth. C.R.O. AVIANO BIO Oncology 1 ‐ Basic Translational 7 € 350.000 RF‐2010‐ 2306205 Noncoding RNAs and cancer IRCCS AOU San Martino‐ IST (Genova) BIO Oncology 1 ‐ Basic Translational 7 € 311.300 RF‐2010‐ 2305957 Enhancement of models for identification of patients with potential benefit from chronic care case/disease management programs. Emilia‐Romagna CLI Healthcare Delivery and Methodologies 7 € 200.000 RF‐2010‐ 2310869 Overcoming the postmitotic state of terminally differentiated cells in favor of regenerative medicine Istituto Superiore di Sanita' BIO Musculoskeletal, Oral and Skin Sciences 7 € 390.000 NOTE Pagina 3 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. RF‐2010‐ 2318827 Microvescicles (MVs) in human Hepatocellular carcinoma (HCC): Potential for diagnostic and therapeutic applications. Abruzzo BIO Oncology 1 ‐ Basic Translational RF‐2010‐ 2321176 NOVEL APPROACH FOR BONE REGENERATION AND REPAIR USING SULFUR DONOR‐BASED THERAPY RIZZOLI BIO GR‐2010‐ 2311017 MacroH2A1 in the pathogenesis of metabolic syndrome‐ associated hepatocellular carcinoma CASA SOLLIEVO SOFFERENZA GR‐2010‐ 2319582 Involvement of microRNAs in triple negative breast cancer: from biology to possible therapeutic applications. ISTITUTO TUMORI MILANO GR‐2010‐ 2316264 Finanz.Richiesto SCORE. 7 € 385.000 Musculoskeletal, Oral and Skin Sciences 7,5 € 565.000 BIO Oncology 1 ‐ Basic Translational 7,5 € 379.555 BIO Oncology 1 ‐ Basic Translational 7,5 € 363.200 CASA SOLLIEVO Deregulation of molecular cross‐talk between NRF2/KEAP1 and BCL2 pathways in Non Small Cell Lung SOFFERENZA Cancer (NSCLC) and Small Cell lung Cancer (SCLC): implications for patients treatment. BIO Oncology 2 ‐ Translational Clinical 7,5 € 350.000 RF‐2010‐ 2301677 Nanotechnology for the multiplex diagnosis of infectious diseases Istituto Superiore di Sanita' BIO Infectious Diseases and Microbiology 7,5 € 560.000 RF‐2010‐ 2310716 Role of Th22 lymphocytes in the expression and persistence of psoriatic phenotype: identification of molecular pathways for innovative biologic therapy ISTITUTO DERMOPATICO DELL'IMMACOLATA BIO Immunology 7,5 € 470.000 RF‐2010‐ 2298992 Modulation of FoxO1 antioxidant function to prevent aging related disorders:diabetes and atherosclerosis Abruzzo BIO Biology of Development and Aging 7,5 € 350.000 RF‐2010‐ 2318830 Role of the immunological impairment in progression of from MGUS to Multiple Myeloma Sicilia BIO Oncology 1 ‐ Basic Translational 7,5 € 460.000 RF‐2010‐ 2318092 Molecular mechanisms underlying metabotropic glutamate (mGlu) receptor dysfunction in Fragile X syndrome OASI MARIA S.S. BIO Molecular, Cellular, and Developmental Neuroscience 7,5 € 530.000 RF‐2010‐ 2318170 Cognitive, physiological and imaging correlates of visual hallucinations in Lewy body dementia: a multimodality functional study S.CAMILLO CLI Brain Disorders and Clinical Neuroscience 7,5 € 280.000 NOTE Pagina 4 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2313390 Amniotic Fluid Stem Cells (AFSCs): molecular markers of Abruzzo osteogenic differentiation and pre‐clinical studies of orthopedic and odontoiatric diseases. BIO Biology of Development and Aging 7,5 € 509.858 RF‐2010‐ 2319485 Nanotechnology‐based approach for induction of immune tolerance Lazio BIO Bioengineering Sciences and Technologies 7,5 € 395.000 RF‐2010‐ 2318880 Prevention and Treatment of Hardware Infection Through Titanium Surface Modifications and Improved Wound Healing Through Nanoparticle Delivery Mechanisms. MAUGERI BIO Bioengineering Sciences and Technologies 8 € 600.000 GR‐2010‐ 2318370 New nanotechnology and biomedical approaches to improve postoperative pain treatment reducing risks related to opioids SAN MATTEO CLI Surgical Sciences, Biomedical Imaging, and Bioengineering 8 € 580.000 GR‐2010‐ 2320784 Development and preclinical assessment of an innovative Veneto endovascular device to occlude prosthetic paravalvular leakage BIO Bioengineering Sciences and Technologies 8 € 540.000 GR‐2010‐ 2311677 High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices Calabria BIO Bioengineering Sciences and Technologies 8 € 600.000 RF‐2010‐ 2302437 RELEVANCE OF TMEM16A PROTEIN (ANOCTAMIN 1) IN THE PATHOPHYSIOLOGY OF CYSTIC FIBROSIS AND GASTROINTESTINAL MOTILITY DISORDERS GASLINI BIO Cell Biology 8 € 600.000 RF‐2010‐ 2312243 Role of relaxin in bone metastasis Veneto BIO Oncology 1 ‐ Basic Translational 8 € 300.000 RF‐2010‐ 2317059 Identification and validation of miRNAs as novel biomarkers and therapeutic targets in diffuse malignant peritoneal mesothelioma ISTITUTO TUMORI MILANO BIO Oncology 2 ‐ Translational Clinical 8 € 500.000 RF‐2010‐ 2309234 Characterization and functions of ROR{gamma}t+ IL22‐ producing innate lymphoid cells in autoimmune and neoplastic human diseases Sicilia BIO Immunology 8 € 390.000 NOTE Pagina 5 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2010‐ 2321104 Optoelectronic retinal prosthesis: the astrocyte approach Toscana to visual restoration. RF‐2010‐ 2308133 Exploiting cellular transcription factors of the Interferon Regulatory Factors family in novel therapeutic approaches to HIV‐1 infection and reactivation from latency RF‐2010‐ 2309867 AREA Classificazione 1 Liv. Finanz.Richiesto SCORE. NOTE BIO Emerging Technologies and Training in Neurosciences 8,25 € 440.000 BIO AIDS and Related Research 8,25 € 546.700 Targeting myeloid cells with novel nanotechnology‐based Veneto platforms to control metastatic disease BIO Oncology 1 ‐ Basic Translational 8,5 € 596.000 GR‐2010‐ 2311890 Identification of miRNAs involved in the regulation of ALK expression in neuroblastoma BIO Oncology 1 ‐ Basic Translational 8,5 € 200.200 GR‐2010‐ 2319335 Lazio Empowering the brain. Induction of Hebbian‐like plasticity in cortico‐cortical neural networks with transcranial magnetic stimulation (TMS): investigations of functional connectivity in healthy subjects and clinical trials in stroke patients BIO Brain Disorders and Clinical Neuroscience 8,5 € 520.000 GR‐2010‐ 2310981 Congenital Myopathies: genetic screening starting from a OSPEDALE BAMBINO new diagnostic algorithm GESU' CLI Musculoskeletal, Oral and Skin Sciences 8,5 € 550.000 RF‐2010‐ 2319081 Hypertension in high school students: Genetic and Environmental Factors Toscana CLI Population Sciences and Epidemiology 8,5 € 600.000 RF‐2010‐ 2314954 Post‐partum depression:chronobiology , sleep‐related risk factors and light therapy Emilia‐Romagna CLI Risk, Prevention and Health Behavior 8,5 € 0 RF‐2010‐ 2316490 Membrane remodeling and its role in malaria parasite infection and pathogenesis Istituto Superiore di Sanita' BIO Infectious Diseases and Microbiology 8,5 € 260.700 RF‐2010‐ 2318970 ROLE OF REGULATORY T‐CELLS IN THE PATHOGENESIS AND THERAPY OF PRIMARY MYELOFIBROSIS SAN MATTEO BIO Oncology 2 ‐ Translational Clinical 8,5 € 240.000 RF‐2010‐ 2312524 EVALUATION OF HUMAN ADIPOSE TISSUE‐DERIVED SAN RAFFAELE PISANA STROMAL CELLS FOR THE TREATMENT OF DIABETIC CARDIOVASCULAR COMPLICATIONS BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 8,5 € 580.000 Istituto Superiore di Sanita' IRCCS AOU San Martino‐ IST (Genova) Pagina 6 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE PROGETTO GR‐2010‐ 2315762 Progressive Neurodegeneration in Primary Immunodeficiencies (PIDs): characterization, genetic predisposition, pathogenesis and identification of predictive biomarkers for diagnosis and follow‐up FATEBENEFRATELLI BIO Immunology 8,5 € 405.020 RF‐2010‐ 2304935 Hypoxia in neuroblastoma tumors: from the biology to the identification of novel predictors of outcome GASLINI BIO Oncology 1 ‐ Basic Translational 8,5 € 318.600 RF‐2010‐ 2309251 Role of Ezh2 in DNA damage response REGINA ELENA BIO Oncology 1 ‐ Basic Translational 8,5 € 600.000 RF‐2010‐ 2302590 Development of new peptide‐mimetic compounds and small organic molecules targeting the ErbB3/p85 interaction to improve ErbB2‐overexpressing metastatic breast cancers therapy REGINA ELENA BIO Oncology 1 ‐ Basic Translational 8,5 € 300.000 RF‐2010‐ 2320561 Regulation of cancer stem cell symmetric divisions by myc I.E.O. BIO Oncology 1 ‐ Basic Translational 8,5 € 600.000 GR‐2010‐ 2307889 The role of macrophages in Primary Biliary Cirrhosis: novel targets for immune intervention HUMANITAS BIO Immunology 8,75 € 539.000 RF‐2010‐ 2316566 Search for new genes and new therapies for Neonatal Diabetes Mellitus (NDM) and Hyperinsulinism and Hypoglycemia (HH). OSPEDALE BAMBINO GESU' CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 8,75 € 300.000 GR‐2010‐ 2320696 Novel multi‐scale approach to 3d cancer models for the discovery of new therapeutic strategies for bone metastases GALEAZZI BIO Oncology 1 ‐ Basic Translational 9 € 600.000 GR‐2010‐ 2319462 Nanometer‐size Gold Clusters Bioconjugates for Efficient C.R.O. AVIANO Drug Delivery BIO Oncology 2 ‐ Translational Clinical 9 € 600.000 GR‐2010‐ 2319005 Dual ErbB‐3 and PI3K/AKT pathway inhibition as a novel Abruzzo approach to targeting cancer BIO Oncology 2 ‐ Translational Clinical 9 € 350.000 GR‐2010‐ 2317750 Targeting neuroprotective endogenous neural stem cells in stroke CLI Brain Disorders and Clinical Neuroscience 9 € 407.000 SANTA LUCIA AREA Classificazione 1 Liv. Finanz.Richiesto CODICE SCORE. NOTE Pagina 7 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2317957 Biochemical markers of brain damage following epileptic Toscana seizures in children and correlation with cognitive outcome and quantitative imaging data CLI Brain Disorders and Clinical Neuroscience 9 € 265.000 RF‐2010‐ 2306483 RAPAMYCIN PLUS DPPIV INHIBITOR IN IMPROVING SAN RAFFAELE MONTE BETA CELL FUNCTION IN LONG‐STANDING TYPE 1 TABOR DIABETES: PROSPECTIVE RANDOMIZED TRIAL BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 9 € 550.000 RF‐2010‐ 2302555 IDENTIFICATION AND VALIDATION OF NEW THERAPEUTIC TARGETS FOR MULTIPLE MYELOMA PATIENTS Emilia‐Romagna BIO Oncology 1 ‐ Basic Translational 9 € 287.777 RF‐2010‐ 2298966 Pre‐clinical assessment of innovative treatments against malignancies based on microRNAs ISTITUTO DERMOPATICO DELL'IMMACOLATA BIO Oncology 2 ‐ Translational Clinical 9 € 400.500 RF‐2010‐ 2321646 The impact of local sleep on awake human behavior Toscana BIO Integrative, Functional, and Cognitive Neuroscience 9 € 580.000 RF‐2010‐ 2302355 Innovation, education and treatment of drug abuse with dual diagnosis (INNUENDO) Abruzzo CLI Risk, Prevention and Health Behavior 9,25 € 300.000 RF‐2010‐ 2320094 Gene identification in rare genetic disorders affecting lysosomal degradation pathways in skeletal muscle. CARLO BESTA BIO Musculoskeletal, Oral and Skin Sciences 9,25 € 480.800 GR‐2010‐ 2313864 Role of hypoxia‐induced miR‐210 in tissue response to peripheral ischemia ISTITUTO DERMOPATICO DELL'IMMACOLATA BIO Vascular and Hematology 9,25 € 600.000 GR‐2010‐ 2320147 Extracellular iron as a key signal in muscle necrosis and regeneration SAN RAFFAELE MONTE TABOR BIO Immunology 9,25 € 350.000 RF‐2010‐ 2316726 Role of HIV‐1 infection on colorectal carcinoma onset and Istituto Superiore di Sanita' progression: development of novel therapeutic strategies BIO AIDS and Related Research 9,25 € 533.500 RF‐2010‐ 2312196 Effects of testosterone supplementation on Emilia‐Romagna erythropoiesis: potential therapeutic implications in the anemia of older patients CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 9,5 € 157.500 NOTE Pagina 8 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2302573 EVALUATION OF THE SENSITIVITY AND SPECIFICITY SAN RAFFAELE MONTE TABOR OF DIFFERENT MEMORY TESTS FOR ALZHEIMERS DISEASE CLI Brain Disorders and Clinical Neuroscience 9,5 € 600.000 GR‐2010‐ 2318314 Autoimmunity to PDGF receptor and DNA instability: a novel pathogenic mechanism with implications for new diagnostic and therapeutic tools in fibrotic diseases Marche BIO Immunology 9,5 € 595.000 GR‐2010‐ 2319057 Robotic Therapy for balance recovery and evaluation in pediatrics OSPEDALE BAMBINO GESU' BIO Integrative, Functional, and Cognitive Neuroscience 9,5 € 330.000 RF‐2010‐ 2317381 New molecular pathways involved in coronary and carotid atherosclerosis SAN RAFFAELE MONTE TABOR BIO Vascular and Hematology 9,5 € 600.000 RF‐2010‐ 2319378 Quantitative assessment of spasticity: physiopathology and clinical application SANTA LUCIA CLI Biobehavioral and Behavioral Processes 9,5 € 454.000 RF‐2010‐ 2315253 Role of squamous cell differentiation regulators in lung cancer. SDN BIO Musculoskeletal, Oral and Skin Sciences 9,5 € 360.000 RF‐2010‐ 2308905 Reactive oxygen species (ROS) and phosphoinositide 3‐ kinase (PI3K) signalling in breast cancer Abruzzo BIO Oncology 1 ‐ Basic Translational 9,5 € 290.451 RF‐2010‐ 2303925 Assessing the immunomodulatory effect of probiotics in the Experimental Model of Myasthenia Gravis CARLO BESTA BIO Brain Disorders and Clinical Neuroscience 9,5 € 495.300 RF‐2010‐ 2311107 ROLE OF THE DNAM‐1/PVR PATHWAY IN THE PATHOGENESIS OF HIV‐1 INFECTION OSPEDALE BAMBINO GESU' BIO AIDS and Related Research 9,5 € 252.500 GR‐2010‐ 2311772 The role of T cells in postmenopausal bone loss: focus on Piemonte autoreactive T cells in peripheral blood of patients affected by severe form of osteoporosis. BIO Immunology 9,5 € 205.000 RF‐2010‐ 2308348 THE GASTRIC SUBMUCOSAL SPACE(GSMS) AS A SITE FOR ISLET ALLOTRANSPLANTATION WITH THE USE OF ALEMTUZUMAB Sicilia BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10 € 600.000 GR‐2010‐ 2319063 The role of eNOS in neoplastic progression induced by chronic stress. PASCALE BIO Oncology 1 ‐ Basic Translational 10 € 600.000 NOTE Pagina 9 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE PROGETTO GR‐2010‐ 2306686 Effects of cognitive and aerobic training on cognitive Abruzzo performances and the resting state brain activity in aging individuals BIO Biobehavioral and Behavioral Processes 10 € 594.000 GR‐2010‐ 2302599 Targeting Histone Acetylation as a Approach to Cancer Therapy BIO Oncology 2 ‐ Translational Clinical 10 € 500.000 GR‐2010‐ 2318215 Assessment of the diagnostic value of novel salivary and Toscana lachrymal biomarkers for the early non‐invasive diagnosis of primary Sjögrens syndrome BIO Musculoskeletal, Oral and Skin Sciences 10 € 405.000 RF‐2010‐ 2309791 SURVEILLANCE OF MULTI‐DRUG RESISTANT (MDR) Sicilia MICRO‐ORGANISM AND FUNGI COLONIZATION AND INFECTIONS ACQUIRED IN A NOSOCOMIAL SETTING, WITH PARTICULAR REFERENCE TO SURGICAL INFECTIONS IN CANCER PATIENTS AND EMERGENCY SURGERY PATIENTS. CLI Risk, Prevention and Health Behavior 10 € 150.000 RF‐2010‐ 2312990 Role of HIF factors in leukemogenesis and evaluation of the effectiveness of their targeting as anti‐leukemia therapy SAN RAFFAELE MONTE TABOR BIO Oncology 1 ‐ Basic Translational 10 € 490.000 RF‐2010‐ 2316030 Translational Research Strategies for Treatment of Acute Neurodegenerative Disorders CARLO BESTA BIO Brain Disorders and Clinical Neuroscience 10 € 566.500 RF‐2010‐ 2317527 A new approach to diagnosis in muscular diseases CARLO BESTA BIO Genes, Genomes and Genetics 10 € 532.550 RF‐2010‐ 2306978 Lysophosphatidic acid (LPA) as a lipid modulator of tumor/stroma cross‐talk during HCC tumor progression ONCOLOGICO DI BARI BIO Oncology 1 ‐ Basic Translational 10 € 500.000 RF‐2010‐ 2318457 Susceptibility to heat in cohorts of births, children and elderly: a multi‐centric study to identify short‐term effects of heat, effect modifiers and to study long term exposure effects over a ten year period Lazio BIO Population Sciences and Epidemiology 10 € 400.000 RF‐2010‐ 2319391 Comprehensive analysis for identification of prognostic and predictive epigenetic signature in Renal Cell Carcinoma REGINA ELENA BIO Oncology 1 ‐ Basic Translational 10 € 450.000 REGINA ELENA AREA Classificazione 1 Liv. Finanz.Richiesto CODICE SCORE. NOTE Pagina 10 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE PROGETTO RF‐2010‐ 2321072 Neurophysiological and functional connectivity markers of fluctuating cognition and attention disorders in Dementia with Lewy Bodies and Parkinsons Disease with Dementia NEUROLESI BIO Brain Disorders and Clinical Neuroscience 10,25 € 400.000 RF‐2010‐ 2314622 DOPAMINERGIC MODULATION OF TONIC GABAA INHBITION: PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS FOR ABSENCE SEIZURES NEUROMED BIO Brain Disorders and Clinical Neuroscience 10,5 € 300.000 GR‐2010‐ 2318791 Study of the role of epigenetics in the regulation of microRNA expression in heart failure to identify novel therapeutic targets HUMANITAS BIO Cardiovascular and Respiratory Sciences 10,5 € 572.000 GR‐2010‐ 2321515 Modulation of HIF by new synthetic PHD2 inhibitors for a new and effective treatment of ischemic heart failure SAN DONATO BIO Cardiovascular and Respiratory Sciences 10,5 € 500.000 GR‐2010‐ 2311146 Long term safety and efficacy of thalidomide in IBD. BURLO GAROFALO CLI Digestive, Kidney and Urological Systems 10,5 € 425.000 RF‐2010‐ 2319721 Whole‐exome approach to identify the gene responsible for a novel condition associating severe mental retardation with skeletal dysplasia (SEMD‐Mental Retardation) ARCISPEDALE BIO Genes, Genomes and Genetics 10,5 € 184.100 RF‐2010‐ 2311325 ROLE OF TGFbeta AND HER‐2 PATHWAYS IN THE DEVELOPMENT OF EMT, ENDOCRINE RESISTANCE AND BREAST CANCER PROGRESSION Sicilia BIO Oncology 2 ‐ Translational Clinical 10,5 € 585.000 RF‐2010‐ 2307091 ECHOCARDIOGRAPHIC EPICARDIAL FAT THICKNESS SAN DONATO AS NEW PREDICTIVE MARKER OF CARDIOVASCULAR EVENTS AND CARDIAC REMODELLING CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10,5 € 150.000 RF‐2010‐ 2314888 PRE‐CLINICAL EVALUATIONS OF CELL THERAPY FOR RIZZOLI OSTEOARTHRITIS TREATMENT BIO Musculoskeletal, Oral and Skin Sciences 10,5 € 520.000 RF‐2010‐ 2306728 Molecular and metabolic signature of Gleason grading in prostate cancer BIO Oncology 1 ‐ Basic Translational 10,5 € 450.000 Emilia‐Romagna AREA Classificazione 1 Liv. Finanz.Richiesto CODICE SCORE. NOTE Pagina 11 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2310964 A toxicological redox assay as a new tool for the discovery MONDINO of susceptibility biomarkers in Parkinsons disease BIO Brain Disorders and Clinical Neuroscience 10,75 € 492.800 RF‐2010‐ 2315335 Genomic and proteomic profiling in Traumatic Brain Injury patients. Sicilia BIO Brain Disorders and Clinical Neuroscience 11 € 397.000 GR‐2010‐ 2319243 Collaboratory and remote mentoring: a strategy to optimize pancreatic islet isolation . Sicilia BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11 € 462.000 GR‐2010‐ 2319431 Chimeric antigen receptor‐redirected T cells targeting CD19 for therapy of high‐risk/relapsed childhood acute lymphoblastic leukemia OSPEDALE BAMBINO GESU' BIO Oncology 2 ‐ Translational Clinical 11 € 600.000 GR‐2010‐ 2321629 Fragile X Protein in breast cancer progression CASA SOLLIEVO SOFFERENZA BIO Oncology 1 ‐ Basic Translational 11 € 500.000 GR‐2010‐ 2309252 MicroRNA as predictive biomarkers in Hepatoblastoma pediatric tumour Istituto Superiore di Sanita' BIO Oncology 1 ‐ Basic Translational 11 € 550.000 GR‐2010‐ 2318041 Enteric glial cells: at the crossroads of obesity, gastrointestinal neurodysfunction and gut bacterial endotoxins MEDEA BIO Digestive, Kidney and Urological Systems 11 € 460.000 GR‐2010‐ 2318297 Exploring the role of Epstein‐Barr virus infection and innate immune signalling pathways in the pathogenesis of myasthenia gravis CARLO BESTA BIO Brain Disorders and Clinical Neuroscience 11 € 567.248 RF‐2010‐ 2318911 CLINICAL AND GENETIC CHARACTERIZATION OF EARLY COMPLICATIONS IN JUVENILE OBESITY OSPEDALE BAMBINO GESU' CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11 € 592.000 RF‐2010‐ 2315795 Genetics of cardiovascular disease in patients with type 2 diabetes. An integrated approach, including epidemiology, gene expression profiles and cell biology functional studies CASA SOLLIEVO SOFFERENZA BIO Genes, Genomes and Genetics 11 € 600.000 RF‐2010‐ 2311016 Hexanucleotide repeat expansion in c9orf72 as a bridge between amyotrophic lateral sclerosis and other neurodegenerative diseases. AUXOLOGICO BIO Brain Disorders and Clinical Neuroscience 11 € 593.000 NOTE Pagina 12 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO CODICE PROGETTO RF‐2010‐ 2309665 A novel in‐vivo diagnostic test for Creutzfeldt‐Jakob disease (CJD) patients by nasal brushing GR‐2010‐ 2318650 DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto SCORE. BIO Brain Disorders and Clinical Neuroscience 11 € 270.000 Group I metabotropic glutamate receptors and regulation NEUROMED of synaptic plasticity in a mouse model of Angelman syndrome BIO Brain Disorders and Clinical Neuroscience 11 € 300.000 RF‐2010‐ 2309134 New insigths in the treatment of necrotizing enterocolitis: Modulation of the cholinergic anti‐ inflammatory pathway with the use of melanocortins in an experimental neonatal model. Sicilia BIO Surgical Sciences, Biomedical Imaging, and Bioengineering 11 € 300.000 RF‐2010‐ 2317851 Unveiling the microbial signature of Coeliac Disease SDN BIO Infectious Diseases and Microbiology 11 € 550.000 RF‐2010‐ 2299665 Novel therapeutic approaches to counteract neuronal loss Abruzzo and cognitive decline in an animal model of AD BIO Brain Disorders and Clinical Neuroscience 11 € 592.072 RF‐2010‐ 2308550 ADVANCED THERAPY IN THE TREATMENT OF SKIN LOSS: HUMAN ALLODERMIS WITH PLATELET GEL AND MINIMALLY MANIPULATED MESENCHIMAL STEM CELLS. Toscana CLI Surgical Sciences, Biomedical Imaging, and Bioengineering 11 € 372.000 RF‐2010‐ 2304785 Correction of Beta‐Haemoglobinopathies after in situ gene transfer by homologous recombination Liguria BIO Genes, Genomes and Genetics 11 € 400.000 RF‐2010‐ 2307118 Molecular genetic variants and circulating levels of natriuretic peptides: assessment of their predictive role for cardiovascular acute events and cardiovascular diseases in a general Italian population NEUROMED CLI Cardiovascular and Respiratory Sciences 11 € 300.000 RF‐2010‐ 2320967 The early phases of diabetic retinopathy: possible role of Pigmented Epithelium Derived Factor in contrasting neuroglial dysfunction Istituto Superiore di Sanita' BIO Cell Biology 11 € 380.000 GR‐2010‐ 2311620 DO INHIBITORY NETWORKS SUSTAIN SEIZURE GENESIS IN FOCAL EPILEPSY? CARLO BESTA BIO Brain Disorders and Clinical Neuroscience 11,25 € 300.500 Istituto Superiore di Sanita' NOTE Pagina 13 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2312459 Cellular and molecular determinants of mitral valve prolapse MONZINO BIO Cardiovascular and Respiratory Sciences 11,5 € 405.556 RF‐2010‐ 2312101 Toxins produced by intestinal bacteria and predisposing genetic variations: a dangerous link for colorectal cancer development? Istituto Superiore di Sanita' BIO Oncology 1 ‐ Basic Translational 11,5 € 397.000 GR‐2010‐ 2313839 Acid Retinoic‐Producing Dendritic Cells as New Therapy for Type 1 Diabetes Sicilia BIO Immunology 11,5 € 180.000 GR‐2010‐ 2311169 Autoimmunity in Diabetes: a Holistic Hypothesis of the Diabetes Syndrome SAN DONATO BIO Immunology 11,5 € 325.000 GR‐2010‐ 2315189 Circuitry rearrangement and clinical outcome of high technological platform based‐ restorative therapy in an ovine model of stroke: definition of microenvironment interactions and epigenetic modification contribution CARLO BESTA BIO Brain Disorders and Clinical Neuroscience 11,5 € 572.300 GR‐2010‐ 2312195 Mitochondria involvement in synaptic dysfunction during early stage of Alzheimer's disease SANTA LUCIA CLI Brain Disorders and Clinical Neuroscience 11,5 € 407.000 RF‐2010‐ 2318415 Mechanism of hypertrophy in genetically determined Hypertrophic Cardiomyopathy (HCM) Lombardia BIO Cardiovascular and Respiratory Sciences 11,5 € 600.000 RF‐2010‐ 2311018 Identification of humoral and cellular biomarkers for cerebro and coronary acute vascular events NEUROMED CLI Vascular and Hematology 11,5 € 300.000 RF‐2010‐ 2311956 The role of mineralocorticoid receptor (MR) overactivation in obesity:effects of MR blockade in human and animal models of overfeeding. SAN RAFFAELE PISANA BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11,5 € 580.000 RF‐2010‐ 2311565 ANALYSIS OF PHERIPHERAL BLOOD DENDRITIC CELLS IN ALZHEIMERS DISEASE SANTA LUCIA BIO Brain Disorders and Clinical Neuroscience 11,5 € 400.000 RF‐2010‐ 2310625 Production and optimization of cartilage and bone spherules for repairing large bone losses and osteoarthritis. Istituto Superiore di Sanita' BIO Musculoskeletal, Oral and Skin Sciences 11,5 € 500.000 NOTE Pagina 14 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2010‐ 2320054 Disabilityrelated chronic conditions in older adults: an innovative approach to estimate the disease burden and the adherence to evidence‐based pharmacological treatments using linked clinical and administrative data. RF‐2010‐ 2319473 AREA Classificazione 1 Liv. Finanz.Richiesto SCORE. CLI Healthcare Delivery and Methodologies 11,5 € 300.000 Corticostriatal alterations in dopamine‐graft transplanted SANTA LUCIA parkinsonian rats: implications for L‐DOPA therapy BIO Brain Disorders and Clinical Neuroscience 11,5 € 430.000 RF‐2010‐ 2317931 Prediction of targeted therapies for hepatocellular carcinoma through molecular profiling of tumorous and cirrhotic tissue Emilia‐Romagna BIO Oncology 2 ‐ Translational Clinical 11,5 € 540.000 GR‐2010‐ 2312436 The role of B cells in Graft‐versus‐Host Disease after allogeneic hemopoietic cell transplantation Provincia autonoma Bolzano BIO Immunology 11,75 € 275.000 GR‐2010‐ 2308317 Identification of new genetic variations involved in Bipolar I disorder via all exome sequencing of families with high genetic vulnerability from a founder Sardinian population FATEBENEFRATELLI BIO Genes, Genomes and Genetics 12 € 599.000 RF‐2010‐ 2319788 Controlled Ex Vivo Expansion of Human Mesenchymal RIZZOLI Stem Cells Methodologies: A First Step Toward Clinically Relevant Bone Regeneration BIO Cell Biology 12 € 328.000 RF‐2010‐ 2300967 IN PURSUIT OF NOVEL THERAPEUTIC STRATEGIES FOR NON‐ALCOHOLIC FATTY LIVER DISEASE: UNDERSTANDING THE ROLE OF LITAF PROTEIN. OSPEDALE BAMBINO GESU' BIO Digestive, Kidney and Urological Systems 12 € 488.000 RF‐2010‐ 2307645 Exploiting endoplasmic reticulum aminopeptidases modulation for innovative strategies of anticancer immunotherapy OSPEDALE BAMBINO GESU' BIO Immunology 12 € 480.000 RF‐2010‐ 2319774 UNRAVELING MECHANISMS UNDERLYING THE RECOVERY OF WALKING ABILITY IN STROKE SURVIVORS Emilia‐Romagna CLI Brain Disorders and Clinical Neuroscience 12 € 600.000 Lazio NOTE Pagina 15 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. GR‐2010‐ 2315085 Prospective, Randomized, Multi‐Center Trial of Lateral Trendelenburg versus Semi‐Recumbent Body Position in Mechanically Ventilated Patients For The Prevention of Ventilator‐Associated Pneumonia MAGGIORE CLI Infectious Diseases and Microbiology 12 € 600.000 GR‐2010‐ 2317866 New specific calcium inhibitor BZ194 as potential modulator of Myasthenia Gravis CARLO BESTA BIO Brain Disorders and Clinical Neuroscience 12 € 430.000 GR‐2010‐ 2321987 Scaffold‐assisted mesenchymal stem cells therapy for cartilage tissue engineering GALEAZZI BIO Musculoskeletal, Oral and Skin Sciences 12 € 600.000 RF‐2010‐ 2319842 Associations between ambulatory blood pressure AUXOLOGICO monitoring profiles, cognitive decline, and diastolic dysfunction in the very elderly population: a multicentre study to identify novel, population‐specific, management algorithms. CLI Cardiovascular and Respiratory Sciences 12 € 400.000 GR‐2010‐ 2321727 Sodium channel Nav1.1: the most relevant epilepsy gene. Lombardia Pathomechanisms and development of novel therapeutic strategies. BIO Molecular, Cellular, and Developmental Neuroscience 12 € 197.000 RF‐2010‐ 2309532 Role of purinergic receptor P2X7R in ischemic tissue damage and collateral vessels development SAN RAFFAELE PISANA BIO Cardiovascular and Respiratory Sciences 12 € 600.000 RF‐2010‐ 2298967 Studies on the functional role and regulation of a restricted signature of microRNAs in acute myeloid leukemia REGINA ELENA BIO Oncology 1 ‐ Basic Translational 12 € 300.000 RF‐2010‐ 2320500 Validation of a health technology for calculating fractionated doses for pediatric drugs Piemonte CLI Healthcare Delivery and Methodologies 12 € 240.000 RF‐2010‐ 2309615 IDENTIFICATION OF NEW DISEASE GENES IN MITOCHONDRIAL COMPLEX I DEFICIENCY OSPEDALE BAMBINO GESU' BIO Brain Disorders and Clinical Neuroscience 12 € 578.000 RF‐2010‐ 2312752 Adipocyte‐derived leptin as a new tool to manipulate immune response in Tuberculosis Istituto Superiore di Sanita' BIO Infectious Diseases and Microbiology 12 € 600.000 NOTE Pagina 16 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2309741 Hereditary spastic paraplegia: generation of cellular and animal models to dissect the complex interplay of the pathways involved combined with novel tools for disease diagnosis MEDEA BIO Brain Disorders and Clinical Neuroscience 12 € 600.000 RF‐2010‐ 2304907 Turning expression into advantage: a new tool for regulatory T cell therapy BURLO GAROFALO BIO Immunology 12 € 560.000 RF‐2010‐ 2315045 Myocardial regeneration and functional recovery of the infarcted heart:role of pericardial fluids SAN RAFFAELE PISANA BIO Cardiovascular and Respiratory Sciences 12 € 300.000 RF‐2010‐ 2304930 Development of vaccines to control salmonellosis using attenuated strains with altered metal uptake capability Istituto Superiore di Sanita' BIO Veterinary 12 € 480.000 RF‐2010‐ 2320697 Functional validation of candidate oncogenes in pancreatic cancer SAN RAFFAELE MONTE TABOR BIO Oncology 2 ‐ Translational Clinical 12 € 450.000 GR‐2010‐ 2313877 A defect in TLR7 gene expression impaires innate and adaptive immunity in Multiple Sclerosis patients: intracellular mechanisms as therapeutic targets Istituto Superiore di Sanita' BIO Immunology 12,25 € 350.000 RF‐2010‐ 2311277 ULTRA‐HIGH FIELD(7T)MAGNETIC RESONANCE SYSTEM: NEUROMUSCOLAR APPLICATIONS STELLA MARIS CLI Brain Disorders and Clinical Neuroscience 12,5 € 178.500 RF‐2010‐ 2303770 Role of Human Papilloma Virus in Head and Neck Cancer. I.E.O. BIO Infectious Diseases and Microbiology 12,5 € 360.000 RF‐2010‐ 2312240 Molecular characterization of the epithelial‐mesenchimal SAN MATTEO transition process underlying idiopathic pulmonary fibrosis and lung cancer. BIO Cardiovascular and Respiratory Sciences 12,5 € 500.000 RF‐2010‐ 2315861 Role of multiple HPV infections in the development of cervical diseases. BURLO GAROFALO CLI Infectious Diseases and Microbiology 12,5 € 175.000 RF‐2010‐ 2314813 MEDITERRANEAN DIET, PHYTO‐ESTROGENS AND RECURRENCE OF COLORECTAL ADENOMAS. A MULTICENTER RANDOMIZED CONTROLLED TRIAL . DE BELLIS BIO Oncology 2 ‐ Translational Clinical 12,5 € 400.000 NOTE Pagina 17 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2313125 The role of microbial agents in prostate cancer pathogenesis C.R.O. AVIANO BIO Oncology 2 ‐ Translational Clinical 12,5 € 463.290 RF‐2010‐ 2321885 FK‐506 Pharmacogenetics/Pharmacogenomics and new approaches in FK‐506 therapeutic drug monitoring in pediatric and adult liver transplantation Piemonte BIO Immunology 12,5 € 300.000 GR‐2010‐ 2321227 Unravelling the susceptibility to develop rotator cuff tears OSPEDALE BAMBINO and its role onto surgical outcome GESU' CLI Musculoskeletal, Oral and Skin Sciences 12,5 € 290.000 GR‐2010‐ 2317163 Modularity for sensory motor control: implications of muscles synergies in motor recovery after stroke. S.CAMILLO CLI Biobehavioral and Behavioral Processes 12,5 € 294.000 GR‐2010‐ 2311331 INTERMED Self Assessment Study (IMSAS) ‐ Self‐ assessed clinical evaluation of bio‐psycho‐social complexity Emilia‐Romagna CLI Healthcare Delivery and Methodologies 12,5 € 110.000 GR‐2010‐ 2305115 Pathway association and genetic interaction analysis for genome wide association study of cerebrovascular ischemic diseases in the Italian population CARLO BESTA CLI Genes, Genomes and Genetics 12,5 € 571.100 RF‐2010‐ 2312613 Phenotypic characterization and genomic sequencing in schizophrenia SAN RAFFAELE PISANA BIO Genes, Genomes and Genetics 12,5 € 593.000 GR‐2010‐ 2321373 Investigation of B cell function and diversity in patients with SCID‐X1 following HSCT or gene therapy Toscana BIO Immunology 12,75 € 195.000 RF‐2010‐ 2314589 Modulation of pharmacogenomic and pharmacodynamic Toscana biomarkers of glucose metabolism by metronomic chemotherapy in cancer and endothelial cells BIO Oncology 2 ‐ Translational Clinical 13 € 240.000 GR‐2010‐ 2321033 Pulmonary Valve Implantation using Self‐expanding Tissue Valve without Cardiopulmonary Bypass: a Controlled Randomised Clinical Trial MAGGIORE CLI Surgical Sciences, Biomedical Imaging, and Bioengineering 13 € 460.000 GR‐2010‐ 2321979 Daily at‐home follow‐up of Parkinsons Disease patients motor performance through robotic and portable devices SAN RAFFAELE PISANA BIO Brain Disorders and Clinical Neuroscience 13 € 600.000 NOTE Pagina 18 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. GR‐2010‐ 2320268 Indoleamine 2,3‐Dioxygenase and Peripheral Tolerance to Umbria Exogenous Factor VIII:A Multi‐Centre Study BIO Vascular and Hematology 13 € 284.000 GR‐2010‐ 2310943 NAD‐dependent signaling as a target in cerebrovascular IRCCS AOU San Martino‐ disease: a preclinical assessment in mouse disease models IST (Genova) BIO Brain Disorders and Clinical Neuroscience 13 € 585.000 RF‐2010‐ 2305545 TLR2 at the crossroads between infections and Multiple Sclerosis in human and experimental pathology Lazio BIO Immunology 13 € 400.000 RF‐2010‐ 2315369 Effect of dopamine treatment on neurocognitive functioning in Parkinsons disease: a fMRI study SANTA LUCIA BIO Brain Disorders and Clinical Neuroscience 13 € 400.000 RF‐2010‐ 2309338 Analysis of pattern recognition receptor activation in cognitively impaired subjects SANTA LUCIA BIO Brain Disorders and Clinical Neuroscience 13 € 354.440 RF‐2010‐ 2316216 Molecular bases of phenotypic heterogeneity of Alzheimer's disease: diagnostic and therapeutic implications CARLO BESTA BIO Brain Disorders and Clinical Neuroscience 13 € 540.000 RF‐2010‐ 2320177 From personality to molecular mechanisms through neurocognitive phenotypes: a translational study of liability to compulsive drug‐seeking SANTA LUCIA BIO Brain Disorders and Clinical Neuroscience 13 € 413.600 GR‐2010‐ 2311289 A novel in vivo model to study molecular determinants in C.R.O. AVIANO lymphopoietic disorders BIO Oncology 1 ‐ Basic Translational 13 € 538.800 RF‐2010‐ 2311213 The KidsInPlaces Initiative: an international partnership for the study of societal resilience and early child development Emilia‐Romagna CLI Population Sciences and Epidemiology 13,25 € 220.000 GR‐2010‐ 2318337 In vivo imaging of microglia signature: from mouse models to brain injured patients MAGGIORE BIO Molecular, Cellular, and Developmental Neuroscience 13,25 € 529.000 GR‐2010‐ 2315805 EARLY EVENTS IN THE INDIRECT PATHWAY IN ANIMAL MODELS OF PARKINSONS DISEASE. NEUROMED BIO Brain Disorders and Clinical Neuroscience 13,25 € 290.000 NOTE Pagina 19 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. GR‐2010‐ 2312633 Evaluation of chemotherapy induced liver damage in patients with colorectal liver metastasis using of non invasive tools REGINA ELENA CLI Digestive, Kidney and Urological Systems 13,5 € 250.000 RF‐2010‐ 2319227 Early risk indicators and prevention of dementia following stroke. S.CAMILLO CLI Brain Disorders and Clinical Neuroscience 13,5 € 600.000 GR‐2010‐ 2319078 Integration of high throughput and analytical data to discover biomarkers of cell‐products quality and therapy efficacy in dendritic‐cells‐based cancer immunotherapy studies Istituto Superiore di Sanita' BIO Oncology 2 ‐ Translational Clinical 13,5 € 350.000 RF‐2010‐ 2317978 Glucocorticoid receptor polymorphisms and Corticosteroid‐Binding Globulin polymorphisms may modulate the clinical effects of immunosuppressive therapy with corticosteroids in determining the risk of developing diabetes after kidney transplantation. Marche CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 13,5 € 250.000 RF‐2010‐ 2317080 Clinical impact of accurate patient specific three‐ dimensional treatment planning in molecular radiotherapy ARCISPEDALE BIO Oncology 2 ‐ Translational Clinical 13,5 € 600.000 RF‐2010‐ 2312849 Unlocking tumor immune recognition through self HLA‐ E molecules REGINA ELENA BIO Immunology 13,5 € 300.000 GR‐2010‐ 2319264 Integration of expression profiles and genetic mapping data to identify risk variants in IgA nephropathy Puglia BIO Digestive, Kidney and Urological Systems 13,5 € 450.000 RF‐2010‐ 2319175 DEVELOPMENT OF AN INTEGRATED BIOSTATISTICS AND BIOINFORMATICS FRAMEWORK FOR CLINICAL TRANSLATION AND EVALUATION OF NEW BIOMARKER TECHNOLOGIES ISTITUTO TUMORI MILANO BIO Oncology 2 ‐ Translational Clinical 13,5 € 212.000 RF‐2010‐ 2310982 The neurobiology of social behaviour: physiological and pathological processes in mice and humans Istituto Superiore di Sanita' BIO Biobehavioral and Behavioral Processes 13,75 € 526.000 NOTE Pagina 20 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE PROGETTO RF‐2010‐ 2303796 PREGNANCIES IN WOMEN WITH PREVIOUS ADVERSE OBSTETRIC EVENTS AND PREGNANCY‐ RELATED VENOUS THROMBOEMBOLISM : NEW DIAGNOSTIC TOOLS AND IMPROVEMENT OF THERAPEUTHIC STRATEGIES CASA SOLLIEVO SOFFERENZA BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14 € 300.000 GR‐2010‐ 2321960 Identification of new genes responsible for Albinism phenotype Lombardia BIO Genes, Genomes and Genetics 14 € 220.000 GR‐2010‐ 2308290 Understanding and treating impairment in automatic movements execution in Parkinson's disease IRCCS AOU San Martino‐ IST (Genova) CLI Integrative, Functional, and Cognitive Neuroscience 14 € 150.000 GR‐2010‐ 2306549 Molecular determinants of tumour resistance to radio/chemotherapies Veneto BIO Oncology 2 ‐ Translational Clinical 14 € 450.000 GR‐2010‐ 2315899 Vaccine platform for oncogenic viruses. PASCALE BIO Immunology 14 € 587.500 GR‐2010‐ 2313075 Synaptic alteration of mGluR signaling underlying SHANK3 mutations in intellectual disability and their rescue by pharmacological therapies CARLO BESTA BIO Molecular, Cellular, and Developmental Neuroscience 14 € 360.000 RF‐2010‐ 2312951 Tuberculosis control among immigrants in Italy: a cost‐ effectiveness assessment. Piemonte CLI Infectious Diseases and Microbiology 14 € 360.000 RF‐2010‐ 2320796 Mechanisms of altered DNA methylation in sporadic and REGINA ELENA hereditary colorectal cancer BIO Genes, Genomes and Genetics 14 € 600.000 RF‐2010‐ 2320335 Identification of slow proliferating cancer cells with stem‐ Istituto Superiore di Sanita' like features BIO Oncology 1 ‐ Basic Translational 14 € 570.000 RF‐2010‐ 2314055 Innovative therapeutic approaches against CD49d‐driven C.R.O. AVIANO microenvironmental interactions in chronic lymphocytic leukemia BIO Oncology 1 ‐ Basic Translational 14 € 600.000 RF‐2010‐ 2317730 LCAT MODULATION TO TREAT ATHEROSCLEROTIC CARDIOVASCULAR DISEASE BIO Vascular and Hematology 14 € 350.000 Lombardia AREA Classificazione 1 Liv. Finanz.Richiesto CODICE SCORE. NOTE Pagina 21 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE PROGETTO RF‐2010‐ 2314049 Hormonal implications in the mesothelioma pathogenesis. REGINA ELENA BIO Oncology 1 ‐ Basic Translational 14 € 596.500 RF‐2010‐ 2311234 Emilia‐Romagna Using hyperbaric‐hyperoxigenated‐transportable machine to preserve liver to be transplanted.A new preservation method evaluated throught an animal model transplantation study. BIO Surgical Sciences, Biomedical Imaging, and Bioengineering 14 € 600.000 RF‐2010‐ 2320258 THERapeutically relevant STEM cells for THALassemia (THERSTEMTHAL) Emilia‐Romagna BIO Genes, Genomes and Genetics 14 € 600.000 GR‐2010‐ 2303803 Fighting Alzheimer: new prospectives and therapeutical strategies SANTA LUCIA BIO Brain Disorders and Clinical Neuroscience 14 € 644.800 RF‐2010‐ 2314240 Enpowering neuromodulation by individually tuned brain‐behavior frequency Istituto Superiore di Sanita' BIO Emerging Technologies and Training in Neurosciences 14,25 € 230.000 RF‐2010‐ 2312471 Neurobiological bases of the Impulse Control Disorders: the role of the cerebellum. SANTA LUCIA CLI Brain Disorders and Clinical Neuroscience 14,5 € 230.000 GR‐2010‐ 2318381 Effects of Antidepressant Drugs on Autophagy pathway in MONDINO neurons BIO Brain Disorders and Clinical Neuroscience 14,5 € 600.000 GR‐2010‐ 2314036 Oncolytic HSV vector strategy for the study of TRIM8 role in the pathogenesis of glioblastoma and therapy. CASA SOLLIEVO SOFFERENZA BIO Oncology 1 ‐ Basic Translational 14,5 € 571.000 GR‐2010‐ 2314427 Autoantibodies specific to ATP synthase in the pathogenesis of Alzheimer disease SAN RAFFAELE PISANA BIO Brain Disorders and Clinical Neuroscience 14,5 € 540.000 GR‐2010‐ 2315991 Tailoring electrical parameters of subthalamic nucleus stimulation to treat behavioural symptoms in Parkinsons disease MAGGIORE CLI Brain Disorders and Clinical Neuroscience 14,5 € 408.800 RF‐2010‐ 2314571 Effect of Human C‐Peptide on the Prevention of Diabetic SAN RAFFAELE MONTE Retinopathy and Nephropathy in a Rat Model of Type 2 TABOR Diabetes BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14,5 € 400.000 RF‐2010‐ 2315800 EARLY ENVIRONMENTAL RISK FACTORS AND THE RISK OF DEVELOPING ANOREXIA NERVOSA CLI Brain Disorders and Clinical Neuroscience 14,5 € 350.000 FATEBENEFRATELLI AREA Classificazione 1 Liv. Finanz.Richiesto CODICE SCORE. NOTE Pagina 22 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE PROGETTO RF‐2010‐ 2314660 Myocardial Toll‐like receptors in human myocarditis. SAN RAFFAELE PISANA CLI Cardiovascular and Respiratory Sciences 14,5 € 363.000 RF‐2010‐ 2312530 Wnt/b‐catenin signaling in melanoma: in vitro and in vivo investigations SAN GALLICANO BIO Oncology 1 ‐ Basic Translational 14,5 € 520.000 RF‐2010‐ 2313681 Use of antisense oligonucleotides to PTPN22 gene variant OSPEDALE BAMBINO conjugated to immuno‐liposomes as a novel therapeutic GESU' approach in type 1 diabetes and autoimmune polyendocrine syndrome type 3 variant CLI Immunology 14,5 € 600.000 RF‐2010‐ 2307217 Wilson disease: methionine metabolism and epigenetic regulation of gene expression BIO Genes, Genomes and Genetics 14,5 € 500.000 RF‐2010‐ 2315965 Host biomarkers in exhalate breath condensate and other SAN RAFFAELE MONTE accessible body fluids for clinical and incipient TABOR tuberculosis detection BIO Infectious Diseases and Microbiology 14,5 € 600.000 RF‐2010‐ 2320384 Preclinical studies on TM9SF4, a novel potential biomarker associated with malignancy in patients with skin cancers Istituto Superiore di Sanita' BIO Oncology 1 ‐ Basic Translational 14,5 € 500.000 RF‐2010‐ 2312125 Role of Notch in regulation of mesenchymal cells from adipose tissue of heart failure patients: consequences for cell therapy MAUGERI BIO Cardiovascular and Respiratory Sciences 14,5 € 400.000 RF‐2010‐ 2317428 DEVELOPMENT OF VALIDATED INSTRUMENTS TO ASSESS SPINAL CORD INJURY (SCI) SUBJECTS. SANTA LUCIA CLI Brain Disorders and Clinical Neuroscience 14,75 € 295.000 RF‐2010‐ 2318892 Mother‐delivered infant massage in preterm infants to promote neurodevelopment and bonding: effects on infant sleep and brain maturation STELLA MARIS CLI Brain Disorders and Clinical Neuroscience 14,75 € 115.000 GR‐2010‐ 2309621 NEUROREHABILITATIVE PROGRAM FOR LIMB APRAXIA BY NEUROMODULATION OF LINGUISTIC VICARIOUS SKILLS FATEBENEFRATELLI BIO Integrative, Functional, and Cognitive Neuroscience 14,75 € 580.000 Veneto AREA Classificazione 1 Liv. Finanz.Richiesto CODICE SCORE. NOTE Pagina 23 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. RF‐2010‐ 2319562 Study of the interactions between noise and vibration Ist. Sup. per la exposure in view of the assessment of synergistic effect on Prevenzione e Sicurezza the cochlea sul Lavoro BIO Risk, Prevention and Health Behavior GR‐2010‐ 2312697 Impaired VitaminD metabolism in Rheumatoid Arthritis. Piemonte Implication for disease pathogenesis and treatment. CLI GR‐2010‐ 2316050 Transcranial Direct Current Stimulation as treatment in depressive illness: mechanism of action and efficacy MAGGIORE GR‐2010‐ 2308883 The role of internal models in locomotor schemas and neurorehabilitation of children with cerebral palsy GR‐2010‐ 2318987 Finanz.Richiesto SCORE. 14,75 € 585.000 Musculoskeletal, Oral and Skin Sciences 15 € 300.000 CLI Brain Disorders and Clinical Neuroscience 15 € 310.000 SANTA LUCIA BIO Brain Disorders and Clinical Neuroscience 15 € 350.000 The VERY SHINING (Vessels, Endothelium and Risk in the next Years. Sodium Handling and INtake: INteractions with Genes) Study. Veneto CLI Cardiovascular and Respiratory Sciences 15 € 400.000 GR‐2010‐ 2313156 Gaining new insights into the molecular mechanisms underlying the cholangiocarcinoma REGINA ELENA BIO Genes, Genomes and Genetics 15 € 250.000 GR‐2010‐ 2316602 Role of FOXP3 in breast cancer metastatic process and possible therapeutic targeting ISTITUTO TUMORI MILANO BIO Oncology 1 ‐ Basic Translational 15 € 357.500 GR‐2010‐ 2309328 Novel strategies for tackling obesity epidemics by targeting the resting energy expenditure (EE) AUXOLOGICO CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 15 € 460.000 GR‐2010‐ 2312856 GENERATION OF PRION PROTEIN‐BASED COMPOUNDS AS NOVEL THERAPEUTIC STRATEGY FOR ALZHEIMER'S DISEASE Lombardia BIO Brain Disorders and Clinical Neuroscience 15 € 595.000 GR‐2010‐ 2316389 LONGITUDINAL CHANGES IN MICROARCHITECTURE REGINA ELENA AND NEURONAL METABOLISM ASSOCIATED WITH PROPRIOCEPTIVE TRAINING TO AMELIORATE BALANCE IN MULTIPLE SCLEROSIS CLI Emerging Technologies and Training in Neurosciences 15 € 415.000 RF‐2010‐ 2318768 Shaping the autoimmune response in the gut: the role of intestinal microbiota in immune regulation of Type 1 Diabetes BIO Immunology 15 € 500.000 SAN RAFFAELE MONTE TABOR NOTE Pagina 24 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE PROGETTO GR‐2010‐ 2318218 Diffusion Weighted Imaging (DWI) for the detection and Veneto monitoring of pulmonary inflammation: preliminary assessment and validation with molecular imaging. BIO Surgical Sciences, Biomedical Imaging, and Bioengineering 15 € 300.000 GR‐2010‐ 2317973 Cerebrospinal fluid and serum biomarkers of brain damage in epilepsy CLI Brain Disorders and Clinical Neuroscience 15 € 370.500 RF‐2010‐ 2316350 Induced pluripotent stem cell (iPSC) technology in the HUMANITAS study of human genetic diseases of the hematologic system: modelling and correcting the cellular and genetic defect BIO Immunology 15 € 600.000 GR‐2010‐ 2309479 Risk assessment and safety procedures for MRI examination on patients with deep brain stimulators Istituto Superiore di Sanita' BIO Surgical Sciences, Biomedical Imaging, and Bioengineering 15 € 400.000 RF‐2010‐ 2314737 Multimodal optical imaging platform for video‐rate Provincia autonoma Trento intraoperative near infrared fluorescence cardiac imaging. BIO Surgical Sciences, Biomedical Imaging, and Bioengineering 15 € 520.000 GR‐2010‐ 2319145 Identification of predictive biomarkers of pegIFN‐alpha‐ induced depression and comprehension of the underlying mechanisms FATEBENEFRATELLI BIO Brain Disorders and Clinical Neuroscience 15 € 400.000 RF‐2010‐ 2318954 Identification of new biomarkers in rhabdomyosarcoma: potential targets of novel therapeutic strategies. OSPEDALE BAMBINO GESU' BIO Oncology 1 ‐ Basic Translational 15 € 600.000 RF‐2010‐ 2319109 OVERCOMING TARGETED TREATMENT RESISTANCE REGINA ELENA IN HUMAN CANCER: NOVEL STRATEGIES TO INHIBIT SURVIVAL AND ESCAPE SIGNALS AND TARGETED DELIVERY OF ANTI‐CANCER NANOPARTICLES BIO Oncology 2 ‐ Translational Clinical 15 € 600.000 RF‐2010‐ 2314017 Exploitation of immunogenic tumor cell death for improved dendritic cell‐based cancer vaccines C.R.O. AVIANO BIO Oncology 2 ‐ Translational Clinical 15 € 550.000 RF‐2010‐ 2314997 Identification of a panel of enteric‐hepatic biomarkers in children with an elevated risk of cardiovascular disease and type 2 diabetes Toscana CLI Cardiovascular and Respiratory Sciences 15 € 581.000 NEUROLESI AREA Classificazione 1 Liv. Finanz.Richiesto CODICE SCORE. NOTE Pagina 25 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2317496 Plasma factors, integrins and modulators of podocyte shape. A new window on focal segmental glomerulosclerosis and its treatment GASLINI BIO Digestive, Kidney and Urological Systems 15 € 208.440 RF‐2010‐ 2318760 The impact of the insulin/IGF‐I pathway in bladder cancer invasion and metastasis Calabria BIO Oncology 1 ‐ Basic Translational 15 € 420.000 GR‐2010‐ 2299397 Development of new strategies to study alcoholism: evaluation of toxicity, tolerance and ethanol dependence mechanisms by molecular imaging, genetic and epigenetic analysis Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise BIO Molecular, Cellular, and Developmental Neuroscience 15 € 433.000 RF‐2010‐ 2319269 DIALECTICAL BEHAVIOR THERAPY (DBT) VS. HIGH‐ QUALITY OUTPATIENT CARE FOR BORDERLINE PERSONALITY DISORDER. A PRAGMATIC RANDOMIZED TRIAL. Emilia‐Romagna CLI Biobehavioral and Behavioral Processes 15 € 300.000 RF‐2010‐ 2311225 Improving the diagnostic homogeneity in schizophrenia using cognitive endophenotypes: an integrated genetic, neuroimaging and neurocognitive approach SANTA LUCIA CLI Brain Disorders and Clinical Neuroscience 15,25 € 600.000 RF‐2010‐ 2319204 Targeting mitochondria‐associated Heat Shock Proteins, autophagy and bioenergetics in human solid tumors MAGGIORE BIO Oncology 2 ‐ Translational Clinical 15,5 € 380.000 GR‐2010‐ 2321042 Neural correlates of apathy and Executive Dysfunction in NEUROLESI Parkinsons disease. BIO Brain Disorders and Clinical Neuroscience 15,5 € 420.000 GR‐2010‐ 2312269 Neural response to behavioral treatments in Focal Hand Dystonia Veneto CLI Brain Disorders and Clinical Neuroscience 15,5 € 385.000 GR‐2010‐ 2319406 Neurophysiological indices of functional network integration in vegetative and minimally conscious patients and their relation to awareness and prognosis SANTA LUCIA CLI Brain Disorders and Clinical Neuroscience 15,5 € 490.000 GR‐2010‐ 2313440 Molecular tools for the diagnosis and treatment of early placentation defects and related pregnancy pathologies BURLO GAROFALO BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 15,5 € 225.000 NOTE Pagina 26 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2315471 Muscle Catabolism Fuels Anabolic Tumor Growth: Translational and Therapeutic Implications GASLINI BIO Oncology 1 ‐ Basic Translational 15,5 € 258.000 RF‐2010‐ 2306180 Development of Training Optimization Techniques for Robot‐assisted Neurorehabilitation. MAUGERI BIO Brain Disorders and Clinical Neuroscience 15,5 € 450.000 RF‐2010‐ 2312206 MicroRNAs as potential diagnostic and therapeutic tools for Multiple Osteochondromas disease RIZZOLI BIO Musculoskeletal, Oral and Skin Sciences 15,5 € 468.000 RF‐2010‐ 2305056 Cancer and Heart study: Cancer from Radiological medical imaging in cardiovascular patients Toscana CLI Cardiovascular and Respiratory Sciences 15,5 € 301.000 RF‐2010‐ 2317543 Air pollution, Epigenomic Arterial Signatures, and Post Heart‐Surgery Risk of Cardiovascular Events MAGGIORE BIO Genes, Genomes and Genetics 15,5 € 570.000 RF‐2010‐ 2320087 Hormonal changes and impaired spermatogenesis in young males with different levels of spinal cord injury: A longitudinal study MAUGERI CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 15,5 € 150.000 RF‐2010‐ 2309199 Brain‐heart axis impairment in stroke patients: integration of neuroimaging data with cardiovascular variability signals. Istituto Superiore di Sanita' BIO Brain Disorders and Clinical Neuroscience 15,5 € 395.000 RF‐2010‐ 2319131 Global and gene‐specific DNA methylation in maternal‐ Lazio infant pairs, environmental exposures, and subsequent respiratory and neurobehavioral phenotypes in childhood BIO Genes, Genomes and Genetics 15,5 € 600.000 GR‐2010‐ 2319470 ELBA.PSDEcological Language Behaviour Assessment For Post Stroke Dementia S.CAMILLO CLI Biobehavioral and Behavioral Processes 15,75 € 200.000 RF‐2010‐ 2311912 Lower limb robotic exoskeleton for children with motor impairment OSPEDALE BAMBINO GESU' CLI Musculoskeletal, Oral and Skin Sciences 15,75 € 600.000 RF‐2010‐ 2321986 Oxidative stress induced DNA damage response and autophagy in skeletal muscle cells: mechanisms and implication for muscle dystrophy SANTA LUCIA BIO Biology of Development and Aging 15,75 € 600.000 GR‐2010‐ 2300170 Impact of influenza vaccination in HIV‐1 multi‐treated elderly patients Istituto Superiore di Sanita' BIO AIDS and Related Research 16 € 435.000 NOTE Pagina 27 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2321005 Study of SP‐A polymorphisms as a predictor of over‐all lung transplant outcome. SAN MATTEO BIO Cardiovascular and Respiratory Sciences 16 € 300.000 RF‐2010‐ 2315568 Clinical and molecular genetic spectrum of Coenzyme Q10 deficiencies: identifications of new phenotypes and genetic variants. Implications for the pathogenesis and therapeutic approach. NEUROLESI CLI Genes, Genomes and Genetics 16 € 338.000 RF‐2010‐ 2314830 The hMena alternative splicing program and host immune response in EMT and breast tumor progression REGINA ELENA BIO Oncology 1 ‐ Basic Translational 16 € 280.000 RF‐2010‐ 2315820 Innovative combinatorial therapeutic strategies to revert resistance to target therapy in NSCLC PASCALE BIO Oncology 2 ‐ Translational Clinical 16 € 580.000 RF‐2010‐ 2317064 Biocompetent dendrons (BD) vs platelet‐rich plasma (PRP) finalized to induce angiogenesis and bone regeneration in osteonecrosis. Marche BIO Musculoskeletal, Oral and Skin Sciences 16 € 480.000 RF‐2010‐ 2310905 Gene identification in muscle disorders disrupting cell‐ extracellular matrix interactions CARLO BESTA BIO Musculoskeletal, Oral and Skin Sciences 16 € 480.500 RF‐2010‐ 2319783 Preventing onset of psychosis in high risk youths: identification and treatment MONDINO CLI Brain Disorders and Clinical Neuroscience 16 € 396.000 RF‐2010‐ 2318826 Autoimmunome‐driven immunotherapy of Alzheimer's Disease Piemonte BIO Brain Disorders and Clinical Neuroscience 16,25 € 280.000 GR‐2010‐ 2319637 Structure, Function and New Insight Strategies for Prevention of Left Atrium Remodeling In Mouse Heart Failure MONZINO BIO Cardiovascular and Respiratory Sciences 16,5 € 510.000 GR‐2010‐ 2304836 Role of Mcl‐1 protein in tumor angiogenesis and progression REGINA ELENA BIO Oncology 1 ‐ Basic Translational 16,5 € 400.000 GR‐2010‐ 2311275 Multimodality MR imaging (DTI, fMRI and quantitative relaxometry) for the evaluation of cerebral modifications induced by different rehabilitation protocols in children with cerebral palsy and traumatic brain injury. MEDEA CLI Brain Disorders and Clinical Neuroscience 16,5 € 545.000 NOTE Pagina 28 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2010‐ 2312350 PHENOTYPE VARIABILITY IN PRNP E200K MUTATION Istituto Superiore di Sanita' CARRIERS: A CLINICAL, GENETIC AND PROTEOMIC STUDY GR‐2010‐ 2317988 SiPIMIS (Single Portal with Intraperitoneal Magnetic Instruments Surgery): a brand new no scar surgical approach for major abdominal intervention. RF‐2010‐ 2312902 Assessment and management of risk factors for sleep disordered breathing and sleep bruxism in pediatric populations. The role of Orthodontics. GR‐2010‐ 2313277 AREA Classificazione 1 Liv. Finanz.Richiesto SCORE. NOTE BIO Genes, Genomes and Genetics 16,5 € 580.000 Lombardia BIO Surgical Sciences, Biomedical Imaging, and Bioengineering 16,5 € 210.540 Emilia‐Romagna CLI Integrative, Functional, and Cognitive Neuroscience 16,75 € 85.000 Engineering the microenvironment of implantable IRCCS AOU San Martino‐ matrices to enhance the host response to tissue damages: IST (Genova) a new regenerative medicine approach for wound healing BIO Cell Biology 17 € 450.000 GR‐2010‐ 2308645 Biotherapy of Colorectal Carcinoma by enhancing HLA‐ class II expression and cooperation with CD16+ myeloid cells in the CRC microenvironment Lazio BIO Oncology 2 ‐ Translational Clinical 17 € 0 GR‐2010‐ 2320517 Biomarkers of adverse neuropsychological outcomes in pre‐term newborns: Structural/functional connectivity Magnetic Resonance Imaging (MRI), Electroencephalography (EEG) and genetics Abruzzo CLI Brain Disorders and Clinical Neuroscience 17 € 202.000 GR‐2010‐ 2319832 Linguistic competence screening for dementia in patients S.CAMILLO with ischemic stroke. CLI Biobehavioral and Behavioral Processes 17 € 200.000 RF‐2010‐ 2311128 Genetics and molecular biomarkers of Food Allergy Toscana BIO Genes, Genomes and Genetics 17 € 300.000 RF‐2010‐ 2304912 Genomic and Proteomic Biomarkers in Patients with Subarachnoid Hemorrhage Sicilia BIO Brain Disorders and Clinical Neuroscience 17 € 585.000 RF‐2010‐ 2311814 Multimodal MRI in the degenerative brain diseases SANTA LUCIA CLI Brain Disorders and Clinical Neuroscience 17 € 594.000 Pagina 29 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2314311 Nutrient Signaling Pathways and Immune Response in the Sensitization of Neuroblastoma and Breast Cancer to Chemotherapy GASLINI BIO Oncology 2 ‐ Translational Clinical 17 € 450.000 RF‐2010‐ 2315009 Bioengineering of TAVI Istituto Superiore di Sanita' BIO Cardiovascular and Respiratory Sciences 17 € 400.000 GR‐2010‐ 2309161 Cancer stem cells as a model of carcinogenesis for head and neck squamous cell carcinoma: new technologies with potential to translate from the laboratory into the clinic. CROB BIO Oncology 2 ‐ Translational Clinical 17 € 500.000 RF‐2010‐ 2310650 Recruitment, computer‐assisted electroencephalographic MONDINO analysis and functional evaluation in Encephalopathy with Status Epilepticus during Sleep/Continuous Spike and Waves during Sleep. CLI Brain Disorders and Clinical Neuroscience 17,25 € 394.000 RF‐2010‐ 2317962 Predicting recidivism of driving under the influence of alcohol and drug. A genetic, neuropsychological and evoked potential study. Veneto BIO Biobehavioral and Behavioral Processes 17,5 € 250.000 GR‐2010‐ 2310058 HUNT FOR NEW DISEASE GENES IN CONGENITAL MUSCULAR DYSTROPHY WITH HYPOGLYCOSYLATED ALPHA‐DYSTROGLYCAN STELLA MARIS BIO Brain Disorders and Clinical Neuroscience 17,5 € 465.000 GR‐2010‐ 2314305 Clinical and biological markers in unipolar vs bipolar depression FATEBENEFRATELLI BIO Brain Disorders and Clinical Neuroscience 17,5 € 600.000 RF‐2010‐ 2306863 HEREDITARY EARLY ONSET ATAXIAS: DIAGNOSTIC PROTOCOLS AND THERAPEUTIC STRATEGIES OSPEDALE BAMBINO GESU' CLI Brain Disorders and Clinical Neuroscience 17,5 € 520.000 GR‐2010‐ 2304348 Mesenchymal stem cells and islet co‐transplantation in diabetic rats: natural chemistry and physical Energy to improve graft revascularization and function by human adipose derived stem cells Emilia‐Romagna BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 17,5 € 600.000 RF‐2010‐ 2319108 Effects of ambulatory oxygen on breathlessness, mobility and quality of life in patients with idiopathic pulmonary fibrosis Toscana CLI Cardiovascular and Respiratory Sciences 17,5 € 250.000 NOTE Pagina 30 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. GR‐2010‐ 2312854 Genetic polymorphism and bisphosphonate‐related osteonecrosis of the jaws: a case control study Emilia‐Romagna BIO Genes, Genomes and Genetics 18 € 225.000 GR‐2010‐ 2315620 Evaluation of effect of PARP inhibitors with or without irradiation in preclinical models of soft‐tissue sarcomas. Toscana BIO Oncology 2 ‐ Translational Clinical 18 € 345.000 GR‐2010‐ 2319358 Quantitative gait analysis in older adults with Alzheimers disease and mild cognitive impairment: pathophysiological meaning and possible clinical applications Toscana CLI Brain Disorders and Clinical Neuroscience 18 € 199.000 RF‐2010‐ 2317818 POST‐STROKE DYSPHAGIA:CLINICAL, COGNITIVE AND NEUROANATOMICAL CORRELATES Lazio CLI Brain Disorders and Clinical Neuroscience 18 € 170.000 RF‐2010‐ 2321774 TUMORIGENIC CELLS OF PANCREATIC CANCER. IN SITUIDENTIFICATION AND CLINICAL SIGNIFICANCE Lazio BIO Interdisciplinary Molecular Sciences and Training 18 € 475.000 GR‐2010‐ 2305274 Iron in cholangiocarcinoma: from understanding the role HUMANITAS to possible development of novel treatments BIO Oncology 1 ‐ Basic Translational 18 € 420.700 RF‐2010‐ 2319339 Studies on antibodies in single‐chain format against the HPV16 E6, E7 oncoproteins as a novel therapeutic approach for HPV‐associated lesions. Istituto Superiore di Sanita' BIO Oncology 2 ‐ Translational Clinical 18 € 480.000 GR‐2010‐ 2306417 Role of leukocyte telomere length and CD34+ hematopoietic precursor telomerase activity in the pathogenesis of cellular senescence in diabetic nephropathy Emilia‐Romagna BIO Digestive, Kidney and Urological Systems 18,5 € 535.555 GR‐2010‐ 2316629 Genetic and functional analysis of circulating microRNAs MAGGIORE in multiple sclerosis: potential prognostic biomarkers of disease course? BIO Brain Disorders and Clinical Neuroscience 18,5 € 598.000 RF‐2010‐ 2317895 Cognitive changes associated with adjuvant chemotherapy (AC) in breast cancer: a FDG‐PET study Toscana CLI Brain Disorders and Clinical Neuroscience 18,75 € 255.000 RF‐2010‐ 2318452 Use of saliva as biological matrix for non invasive screening of oral cancer ‐ ONCOSAL (ONCOlogical Diagnosis by SALiva) CROB BIO Oncology 2 ‐ Translational Clinical 19 € 500.000 NOTE Pagina 31 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. GR‐2010‐ 2314318 Role of type I IFN in dictating the immunogenicity of chemotherapy and in predicting the therapeutic efficacy of anticancer treatments Istituto Superiore di Sanita' BIO Oncology 2 ‐ Translational Clinical 19 € 450.000 RF‐2010‐ 2313911 Hypoxia, necrosis, NF‐kB activation and pro‐ inflammatory genes expression in mesothelioma progression. SAN RAFFAELE PISANA BIO Oncology 1 ‐ Basic Translational 19 € 350.000 RF‐2010‐ 2312946 Experimental and clinical evaluation of the role of obesity Emilia‐Romagna and its treatment in determining and treating decompensation in chronic liver disease BIO Digestive, Kidney and Urological Systems 19 € 590.000 RF‐2010‐ 2310617 Study and application of innovative instrumentation and diagnostic protocols in the clinical electrophysiology of vision Istituto Superiore di Sanita' BIO Emerging Technologies and Training in Neurosciences 19,25 € 350.000 GR‐2010‐ 2319248 Neuroinflammation in cerebral ischemia: discerning the role of G protein beta/gamma complex translocation in reactive gliosis Sicilia BIO Molecular, Cellular, and Developmental Neuroscience 19,25 € 250.000 GR‐2010‐ 2321773 Traditional Chinese Medicine Herbal Drugs as Modulators of Multidrug Resistance in Cancer Cells Toscana BIO Oncology 2 ‐ Translational Clinical 19,5 € 380.000 RF‐2010‐ 2314722 NEURAL BASIS OF FREE WILL AND VOLITIONAL INHIBITION IN PARKINSONS AND PHARMACORESISTANT EPILEPTIC PATIENTS NEUROMED CLI Brain Disorders and Clinical Neuroscience 19,5 € 300.000 RF‐2010‐ 2305061 A web‐based intervention to educate patients with type 2 Emilia‐Romagna diabetes to healthy lifestyles CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 19,5 € 180.000 RF‐2010‐ 2315660 Plasma miRNAs as prognostic factors in patients with Chronic Lymphocytic Leukemia (CLL) ARCISPEDALE BIO Oncology 2 ‐ Translational Clinical 19,5 € 400.000 GR‐2010‐ 2300612 DERMATOLOGIC PROBLEMS IN ONCOLOGICAL PATIENTS. A PREVENTIVE AND THERAPEUTIC APPROACH SAN GALLICANO BIO Musculoskeletal, Oral and Skin Sciences 19,5 € 280.000 NOTE Pagina 32 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE PROGETTO GR‐2010‐ 2321901 "miRNA and protein expression profile in Colorectal cancer: analysis of their potential as screening, prognosis and therapeutic response biomarkers and as therapeutic targets?" Piemonte BIO Oncology 2 ‐ Translational Clinical 20 € 480.000 RF‐2010‐ 2321234 MRI imaging of tumor associated macrophages in the early development of lung and bone metastasis SAN RAFFAELE PISANA BIO Oncology 2 ‐ Translational Clinical 20 € 600.000 GR‐2010‐ 2319216 Loss‐related pain as reflected by cortical responses to SANTA LUCIA nociceptive stimuli in healthy subjects and individuals with complicated grief: perception, electrophysiology and a tentative pharmacological approach BIO Integrative, Functional, and Cognitive Neuroscience 20 € 440.000 RF‐2010‐ 2316037 Genetic contribution to acquired Long QT Syndrome in cancer patients receiving Tyrosine‐Kinase Inhibitors CLI Oncology 2 ‐ Translational Clinical 20 € 600.000 RF‐2010‐ 2318289 Antigen presentation defects and immunoevasion during HUMANITAS colorectal cancer progression BIO Oncology 2 ‐ Translational Clinical 20 € 417.450 RF‐2010‐ 2314748 Vitiligo as model for autoinflammatory‐induced degenerative disease. CLI Musculoskeletal, Oral and Skin Sciences 20,5 € 400.000 GR‐2010‐ 2319189 Circulating microRNAs as biomarkers of Atrial Fibrillation MONZINO CLI Cardiovascular and Respiratory Sciences 20,5 € 297.000 RF‐2010‐ 2316451 New basic and clinical approaches to improve diagnosis Piemonte and therapeutics strategies in extreme phenotypes of type 2 diabetic patients BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 21 € 300.000 GR‐2010‐ 2317776 MICROBEAM STEREOTACTIC RADIOSURGICAL SUBTHALAMOTOMY AS A NEW SYMPTOMATIC TREATMENT FOR PARKINSONS DISEASE NEUROMED BIO Brain Disorders and Clinical Neuroscience 21 € 300.000 GR‐2010‐ 2314876 Synergistic anticancer effects of the iBRAF, iMEK1/2 and iPI3K in melanoma and possible strategies to overcome the drug‐resistance PASCALE BIO Oncology 2 ‐ Translational Clinical 21 € 400.000 MAUGERI SAN GALLICANO AREA Classificazione 1 Liv. Finanz.Richiesto CODICE SCORE. NOTE Pagina 33 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. NOTE RF‐2010‐ 2314303 ASSESSMENT OF THE PHYSIOPATHOLOGICAL MECHANISMS UNDERLYING GLIAL AND NEURONAL DAMAGE AND EVALUATION OF THE NEUROPROTECTIVE EFFECTS EXERTED BY RECOMBINANT ERYTHROPOIETIN AND OTHER TISSUE‐PROTECTIVE MEDIATORS. Sicilia CLI Brain Disorders and Clinical Neuroscience 21,5 € 160.000 GR‐2010‐ 2313802 Development of minimally invasive techniques in treatment of skull base tumors. Anatomic and clinical study. Lazio CLI Surgical Sciences, Biomedical Imaging, and Bioengineering 21,5 € 0 GR‐2010‐ 2317516 Gene Expression Profiles of the aneurysm wall and Genome‐wide screen in patients with Ruptured and Unruptured Intracranial Aneurysm: are there genetic determinants identifying Ruptured Aneurysm and patients at risk of rupture in Aneurysm Population? CARLO BESTA BIO Vascular and Hematology 21,5 € 592.803 GR‐2010‐ 2316826 Diabetes and neurocognition: the role of glycemic control NEUROLESI and vascular comorbidities in elderly people with diabetes CLI Biology of Development and Aging 22 € 162.000 RF‐2010‐ 2320044 Multi‐criteria decision approach (MCDA) to analyse priority setting decisions in the context of a transition from acute‐focused towards chronic care‐focused healthcare systems: implications for the Italian SSN Emilia‐Romagna CLI Healthcare Delivery and Methodologies 22,5 € 570.000 RF‐2010‐ 2316794 Optimizing the combined use of electrical stimulation and dopaminergic drugs in temporal and spatial aspects of action neuro‐rehabilitation Lazio CLI Brain Disorders and Clinical Neuroscience 24,75 € 276.000 RF‐2010‐ 2320746 Control of Feral Dog Populations by Immunocontraception Istituto Zooprofilattico Sperimentale del Lazio e della Toscana BIO Veterinary 26,25 € 415.000 RF‐2010‐ 2319502 Effect of long‐term Physical Activity training on health: epigenetic and OMICs‐ integrated approaches SDN BIO Interdisciplinary Molecular Sciences and Training 26,5 € 441.000 RF‐2010‐ 2320496 Immunological properties of fetal stem cells retrieved from placenta and amniotic fluid Veneto BIO Immunology 26,75 € 492.000 Pagina 34 di 35 BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Finanz.Richiesto CODICE PROGETTO SCORE. RF‐2010‐ 2302821 Adjuvant therapy for resected stage III‐N1 melanoma patients Istituto Superiore di Sanita' CLI Oncology 2 ‐ Translational Clinical 29 € 75.000 GR‐2010‐ 2315979 Investigations on the multifaceted role of Enhancer of Zeste 2 (EZH2) in glioblastoma biology CARLO BESTA BIO Oncology 1 ‐ Basic Translational 36 € 399.000 NOTE LEGENDA NOTE: NOTA 1 = Il PI del Progetto ha richiesto un finanziamento inferiore a quello minimo previsto dal Bando NOTA 2 = Principal Investigator non è operatore SSN NOTA 3 = Il Progettoè risultato uguale ad altro progetto presentato nello stesso Bando anche se in altra sezione Pagina 35 di 35