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Transcript
CHEM 109C – Zhang CLAS, F10 Coenzymes II: Pyridoxal Phosphate (PLP) 1. (Ch 24, #14) What amino acids are formed from the following a-ketoacids in PLP-catalyzed transaminations? a. Pyruvate b. Oxaloacetate 2. (Ch 24, #16) Which of the following compounds is more easily decarboxylated? O O - O O + + N N a. H - b. H 3. (Ch 24, #17) Explain why the ability of PLP to catalyze an amino acid transformation is greatly reduced if a PLP-requiring enzymatic reaction is carried out at a pH at which the pyridine nitrogen is not protonated. 4. (Ch 24, #18) Explain why the ability of PLP to catalyze an amino acid transformation is greatly reduced if the OH substitiuent of the pyridoxal phosphate is replaced by a methyoxy group. 5. Which are the 5 types of reactions that we have learned that PLP catalyzes? Page 1 of 1