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1. Extra 10 will cause a. Will divert to Th2 (because inhibits 12, but something says, if you add 10, goes to Tr1) 2. IL-12 diverts to a. T1 b. T2 3. Sufficient IL4 for autocrine and to help others will impact which pathway a. Th2 b. Tr1 c. Th1 d. Th3 4. Sufficient IL2 for autocrine and to help others will impact which pathway a. Tr1 b. Th2 c. Th1 d. Th3 5. Theory of hygiene is 6. what doesn’t participate in the allergic response a. prostaglandin b. IgE c. IL4 d. Histamine e. Mast cells 7. What does Cyclosporine not cause a. Increase TGF b. Increase in neutrophils c. Not decrease in leukofein d. Decrease in IL-2 8. CD8 works on a. Bacteria only b. Virus only c. Virus and cancer where the DNA is internal 9. which is true a. hemopoietic pluripotent stem cells can make RBC b. common lymphoid progenitor can also make NK c. common lymphoid progenitor cells can make monocytes 10. The repoirtoire of MHC enables a. Strong response in many cases b. Evolutionary strong response to self antigen and weak to virus and bacteria c. Evolutionary of strong response to virus and bacteria where there is crossreacting with self antigens 11. CD8 kills by a. Unlike NK not by granzyme and perforin b. Receptors and injection 12. What is involved in macrophage and virus activation of dendritic cells a. Toll receptors b. CD40L 13. mannose binding lectin is involved a. activating the complement system b. adaptive immunity (it’s innate) c. opsonization 14. N and P sequences are a. Part of the RSS system b. ??? 15. RSS 12/23 rule is a. 12 and 23 long nucleotides only b. 12 on light chain and 23 on heavy chain for joining c. 12 and 23 with heptamer and nonamers also 16. recent theory about newborn immune response a. T cells aren’t mature b. B cells aren’t mature 17. MHC1 functions in killing a. Using the FAS and FAS-ligand b. Apoptosis c. Both 18. NK is activated by a. Decrease in MHC1 b. Increase in MHCI c. Increase in MHCII d. Decrease in MHCII 19. Something about MHC I a. T helper b. CTL 20. Absence of invariant (constant) portion of AB will cause 21. Number of recombinations in kappa light chain is determined by a. TdT b. D region c. J region d. Direction of frame reading 22. Positive selection in the thymus is impacted by a. Signals alone b. Self-antigen or something like that 23. Difference between mature and naïve T cells is in a. Life span b. Rate to move to peripheral tissue c. Rate of response 24. T cells are only activated a. After there is TCR b. TCR exist in the beginning… c. Clonal expansion 25. What is activated without specific activation a. CD25 b. Th1 c. Th2 d. Tr1 e. CD8 26. What isn’t involved in immune response a. CD25 b. Th1 c. Th2 d. CD16 e. B cells 27. Mouse with -/- for IL 10 gets spontaneous Chrone’s disease. What is this connected to 28. peripheral tolerance 29. quantitative and qualitative secondary immune response is a function of a. initial T cell response b. rate of tissue perfusion c. B cell ____ 30. AIRE: autoimmune regulator a. Controls expression… b. Impacts autoimmune diseases c. Something about promiscuity and maturation 31. Decrease in CTLA-4 will cause 32. IgG1 and IgG2 are different a. Isotypes b. Allotypes c. Idiotypes 33. Something about IgE and hypersensitivity 34. Allelic exclusion is expressed a. Recombinations of a single allele b. Expression of recombinations of only one type 35. Monoclonal AB comes from a. Single clone 36. SLE (lupus) a. Immunocomplexes accumulate b. Damage in spinal chord c. Limb paralysis 37. ITP (platelets) a. Treatment will include macrophages and neutrophils that compete with Fc 38. What isn’t true about the lymph system a. Closed system b. Eventually drains to the blood c. cleans the extracellular spaces d. lymphocytes made in the primary lymph nodes e. something abut peripheral lymph nodes 39. attenuated micro-ogranism vs dead one in vaccine a. attenuated has a stronger response b. should NOT give attenuated to someone with an immunodeficient disease c. dead micro-organism cannot cause isotype change d. made safer with recombinant DNA technology e. rarely reverts to virulent strain 40. Use of adjuvant a. Make more immunogenic b. Increase affinity c. Something about solubility, have bacterial products 41. IL-1 acts like hormone in a. Lectin-induced pathway b. Alternative pathway 42. HIV penetrates a. Every cell with both CCR5 and CD4 b. Just CCR5 c. Just CD4 43. intensity of IgE expression is a function of a. Type of allergen 44. liver transplant from parent to child need… a. blood type, one of MHC’s matching 45. Antigen expressed by MHC-2 is via a. Initially dendrites, then later by macrophage and B b. 1st by macrophage and B cells and later by dendrites c. dendrite only d. dendrite and B cells but not macrophage **Questions where one answer choice related to – “anergy” – “Th17” (different question) – Thymic epithelial cells (different question)