Download Clopidogrel Bicarbonate-Platelet Inhibitor Plavix

Action:
Uses: For patients with a
Clopidogrel is an inhibitor of
platelet activation and
aggregation through the
irreversible binding of its
active metabolite to the
P2Y12 class of ADP receptors
on platelets.
history of recent MI,
recent CVA, established
PAD, Plavix has been
shown to reduce the rate
of a combined endpoint of
new ischemic stroke, new
MI , and other vascular
death.
Clopidogrel Bicarbonate-Platelet Inhibitor
Plavix, Clopivas, Zylitt, Clopidogrel, Laviguard
Dosages:
Adult: 300mg/day (loading dose;
only for day 1); 75 mg/day
Can be prescribed without a
loading dose
A: Bioavailibility <50%
D: Protein Binding 9498%
M: Hepatic
E: 50% renal
46% biliary
Routes: PO
Onset: 2h
Peak: 12 h (after initial
dose)
Duration: 24 h (after
initial does)
Half-life: (after initial dose)
6h;
Common Side Effects: fever, diarrhea, taste disorders, hallucinations, headache, bronchospasms,
generalized pruritus
Adverse Effects: hepatic failure, hepatitis (non infectious), hemorrhage (often fatal hemorrhage:
GI, cerebral, musculoskeletal, skin, respiratory tract, surgical wounds), FATAL intracranial
bleeding, elevated creatinine levels, colitis, pancreatitis, pneumonia
Contraindications: Plavix is contraindicated with persons with active bleeding, such as peptic
ulcer; not to be used with tipinovir (a protease HIV medication); not to be used with proton pump
inhibitors, such as acid relievers (this can affect how the drug is eliminated from your body); discuss
use of NSAIDs and other aspirins with your provider prior to Plavix use
Nursing Considerations:
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Educate patient on the risk for bleeds: avoid contact sports (bruising), caution use of sharp
objects like razors (active bleeding);
Carefully monitor for and immediately report S&S of GI bleeding, especially when
coadministered with NSAIDs, aspirin, heparin, or warfarin.
Lab tests: Periodic platelet count and lipid profile.
Evaluate patients with unexplained fever or infection for myelotoxicity.