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I got my B.S. in Mech. Eng. from USTC and joined the first CUSPEA (initiated
by T.D. Lee) group studying physics in USA in 1981. After getting Statistical
Physics PhD from Rutgers University in 1987, I became a postdoc at the Courant
Institute of Mathematics at NYU until I became a Genome Research fellow at
CSHL in 1991. I started my Computational Genomics Lab there in 1996 and
became full professor in 2002. I became 1000-Talent guest professor of Tsinghua
University in 2009 and moved to The University of Texas at Dallas as the Cecil
H. and Ida Green Distinguished endowed chair Professor in 2010. I am currently
the director of Center for Systems Biology at UT Dallas and the co-director of
Center for Synthetic and Systems Biology at Tsinghua U.
Computational Biology of Genome Regulation from 1D to 3D
Michael Q. Zhang
The University of Texas at Dallas & Tsinghua University
Cell fate determination and transformation is intimately related to chromatin interaction and 3D
genome structure. Many 1D cancer or other developmental regulatory disease markers, such
as GWAS SNPs/CNVs, heritable or somatic mutations, gene fusions, viral insertion hotspots,
epi-mutations, etc., are often linked to dis-regulation of cis-regulatory elements to their target
genes through altered 3D DNA loops. I will review the history of computational genome
regulation and then introduce some new biochemical (BL-Hi-C), biophysical (Super-resolution
imaging) and Bioinformatics (MICC, 3CPET, FIND) technology developments that may be used
for studying 3D genomes and disease markers in the near future.