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Parkinson‘s disease and its therapy AUTHOR: MARTIN AMBROZ SUPERVISOR: RNDR. IVA KUBIŠTOVÁ, PH.D. BRNO, APRIL 2015 Why Parkinson‘s disease? incurable disease ongoing development of new therapies PD influences interesting areas of the brain complicated neurosurgery of DBS encompass vast spectrum of knowledge Parkinson‘s disease movement disorder affects basal ganglia neurodegenerative proces of dopaminergic neurons within the substantia nigra leads to deficiency of dopamin in striatum Therapy Farmakological substitution of dopamine main L-DOPA Surgical when patient‘s symptoms are unresponsive to the current medication includes Deep Brain Stimulation Deep Brain Stimulation implanting electrodes into the certain areas of the brain frequently stimulated areas: subthalamic nucleus globus pallidus internus Connecting wire delivers therapeutic stimulation from the pulse generator to the target region of the brain. https://www.youtube.com/watch?v=dbX1t9dfgVE Thank you for the attention!
