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Saturday Scientific Breakthroughs in Parkinson’s Disease CME: 3 hours January 16, 2016 1:15 p.m.–4:15 p.m. Program Director Aleksandar Videnovic, MD, MSc, Boston, MA Program Description Recent years have brought significant scientific developments to the forefront of Parkinson’s disease (PD). This program will encompass selected and diverse scientific topics that have the potential to be transformative for our understanding of PD pathophysiology, diagnosis, treatment, and disease modification. The program will cover emerging concepts related to the similarities between PD and prion disorders with implications for PD treatment. Opportunities and challenges for implementing stem cell based therapies for the treatment of PD will be discussed. Advances in brain imaging and its role in the diagnosis, treatment, and monitoring of PD progression present a tremendous resource to neurologists and other allied health professionals involved in the care of PD patients. Novel developments in our understanding of the biological effects of exercise on neural circuitry emphasize the role of exercise not only in day-to-day routine management, but also in slowing PD progression. Learning Objectives Recommended Audience Upon completion, participants should be able to understand the prion hypothesis of Parkinson’s disease; discuss applications of stem cell based therapies in PD; understand new developments in brain imaging of PD and its implications in clinical care, disease progression, and biomarker research; and understand the biological effects of exercise in PD and its implications in treatment and disease modification. Trainee; General Neurologist; Specialist Neurologist; Non-neurologist; Advanced Practice Provider Core Competencies Interpersonal and Communication Skills; Medical Knowledge; Patient Care; Practice-based Learning and Improvement Schedule 1:15 p.m.–1:20 p.m. Introduction 1:20 p.m.–2:00 p.m. Is Parkinson’s Disease Prion Disease? 2:00 p.m.–2:40 p.m. Human Stem Cell Based Therapies in Parkinson’s Disease: Past, Present, and Future 2:40 p.m.–3:20 p.m. New Scientific Advances in Imaging of Parkinson’s Disease 3:20 p.m.–4:00 p.m. Biological Effects of Exercise in Parkinson’s Disease: Implications for Disease Modification and Clinical Care Aleksandar Videnovic, MD, MSc, Boston, MA Patrik Brundin, MD, PhD, Grand Rapids, MI Ole Isacson, MD, Belmont, MA Jennifer G. Goldman, MD, MS, Chicago, IL Lisa M. Shulman, MD, FAAN, Baltimore, MD 4:00 p.m.–4:15 p.m. Panel Discussion Faculty RECOMMENDED COMPANION COURSE – PAGE 15 Parkinson’s Disease: An Update on Motor and Non-motor Features, Current Treatments, and Clinical Trials in the Pipeline Fast, Easy Registration Online · AAN.com/view/breakthroughs 19