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Fatah Kashanchi, Ph.D. The George Washington University School of Medicine and Health Sciences • • • • Genomics and Proteomics of HIV and other related human retroviruses Resources – 12 members – NIH, DOD, Keck, Snyder funding – Affymetrix, MALDI, LCQ Active collaborations with GWU, NIH, TIGR Output – 86 peer reviewed publications – Director of Genomics and Proteomics MS program – Co-Director of the Institute for Proteomics Technology and development [email protected] 202-994-1781 Human Retroviruses Apoptotic Anti-Apoptotic (Cancerous) HIV (AIDS) HTLV-1 (ATL) Overall approach: Genomics and Proteomics - Standard Microarrays, siRNA, ChIP-Chip - Virus Chip with TIGR - Proteomics and Mass Spec Drug studies and Membrane Proteome - New animal model for HIV using Stem cells (In collaboration with Dr. Saifuddin (Conrad)) Complex Microarray (Computer assisted data analysis) Gene Narrow down to ~20-50 genes to define individual pathways. “Guilt by Association” for unknown genes or for ~2 fold differences Detection of protein complexes (Use of conventional and immunoaffinity chromatography) Mass Spec to determine individual partners Protein Biochemical/Functional Assays Simple Localization studies