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Pharmaceuticals 03 (Keywords: Light-emitting diode (LED), D-Allose, Cancer cells, Light therapy) ●Research representative Kensho Okamoto, Professor, Kagawa University Faculty of Engineering Outline of technology Absorbance Sales points ●Proliferation of cancer cells can be suppressed effectively by a combination of LED irradiation and administration of a rare sugar, both of which have few adverse effects and are minimally invasive. Expected application fields and products (1) (2) (3) (4) Treatment Treatment Treatment Treatment for for for for skin cancer leukemia esophageal, stomach, and colon cancers lung and laryngeal cancers (5) Treatment for penile, vaginal, and uterine cancers (6) Treatment for liver, pancreatic, and ovarian cancers (7) Treatment for diseases due to abnormal cell proliferation Comparison with existing treatments Advantages LED irradiation + D-Allose administration Radiotherapy Disadvantages Therapeutic effect Stress to patients Hemorrhage, etc. Cost No pain No hemorrhage Inexpensive Effective only for early cancers Inexpensive Causes immunosuppression Adverse effects and wasting No hemorrhage Involves risk Chemotherapy Adverse effects No hemorrhage Expensive Symptomatic therapy Surgery Physically painful Causes hemorrhage Expensive Effective if successful References, patents, etc. ●Related industrial property rights: Kokai number (2005) 65977 [Application for evaluation have been made] Other matters to note (Developer’ s comment) While this study was an experiment of in vitro nature, it showed that cancer cell proliferation can be suppressed by the addition of a trace amount of D-allose to the medium and irradiating the medium with blue LED in cancer cell cultures (liver cancer and leukemia cells). However, the cell growth inhibiting effect of blue LED light was slightly reduced by the addition of D-allose in some experiments. (Developer’ s contact address) TEL: +81-87-864-2250 E-mail: [email protected] Kagawa Prefecture Glyco-Biocluster Formation Project Collection of Technological Achievements Related to Rare Sugars Cell count 200 cells/μl Rare sugar 50 mmol/l The growth of cancer cells can be inhibited by both the light of highbrightness light-emitting diode (LED) 96-well plate for MTT (particularly blue and green lights) and the rare sugar D-allose alone, but it can LED light irradiation be inhibited more effectively by their concomitant use. Since both treatments Measurement Day 1 Day 2 Day 3 Culturing in an incubator have few adverse effects and are Time course minimally invasive to patients, the Figure: Changes in the cell count when D-allose was added in a very combination has a great potential as a small amount to the culture medium of K562 chronic new treatment for cancer. myelocytic leukemia cells and irradiated with blue LED light Cancers on the surface such as skin (5W/m2) (proportionate to changes in the absorbance) cancer can be directly irradiated with LED. Blood cancers such as leukemia can be exposed to LED by leading blood temporarily out of the body as in hemodialysis. Cancers of the digestive, respiratory, and reproductive systems such as stomach cancer, lung cancer, and uterine cancer may be irradiated by LED using an LED irradiator attached to various fiberscopes. Intraperitoneal cancers such as liver cancer can be irradiated using a laparoscope mounted with an LED irradiator. D-Allose can be administered by injection, intravenous injection, instillation, topical spraying, or external application as a solution. This treatment is also considered to be effective for the treatment of diseases due to abnormal proliferation of cells other than cancer (such as psoriasis vulgaris and verruca). Glyco-Bio Project Team, Technical Promotion Division, Kagawa Industry Support Foundation 1st floor, FROM Kagawa, 2217-16 Hayashi-cho, Takamatsu City, Kagawa 761-0301 Japan TEL: +81-87-840-0338 FAX: +81-87-864-6303 URL http://www.kagawa-isf.jp/ Suppression of cancer cell proliferation by a combination of lightemitting diode (LED) irradiation and administration of rare sugars ●Research theme