Download 2014 Operating Grants Competition Results

2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
$120,000/ 2 years
Alain, Tommy
Children's Hospital of Eastern Ontario
Dimcho, Bachvarov
Université Laval
Combining mTOR inhibitors and viral oncolysis to
target pancreatic neuroendocrine tumours
Dissecting in vivo the biological role of the
polypeptide N-acetylgalactosaminyltransferase 3
(GALNT3) in ovarian cancer cell invasiveness and its
possible implication in aberrant O-glycosylation of
mucin-like targets
Beattie, Tara
University of Calgary
Influence of telomere dynamics on disease
progression and response to therapeutics in bone
marrow failure syndromes
Beauchemin, Nicole
McGill University
Genetic control of susceptibility to colon cancer
development
Beauséjour, Christian
CHU Ste-Justine, Université de Montréal
Evaluation of the immunogenicity of murine and
human senescent cells
CancerResearchSociety.ca
[email protected]
Funded in partnership with the Steven E. Drabin
Research fund
$120,000/ 2 years
Funded in partnership with Ovarian Cancer Canada
$120,000/ 2 years
Funded in partnership with Alberta Innovates Health
Solutions
$120,000/ 2 years
$120,000/ 2 years
Page 1 of 15
2014 Operating Grants Competition Results
Researcher
Bridle, Byram
University of Guelph
Project Title
Funding Details
Evaluation of Adjunct Oncolytic Immunotherapy in a
Canine Lymphoma Clinical Trial
$120,000/ 2 years
Chan, Gordon
University of Alberta
Altered mitotic checkpoint protein expression and
kinetochore localization: mechanism of checkpoint
defect and aneuploidy in melanoma.
Cloutier, Guy
Université de Montréal
Quantitative ultrasound imaging to reduce the
number of irrelevant biopsies and to follow the
response to neoadjuvant chemotherapy in woman
with operable breast cancers
$120,000/ 2 years
Funded in partnership with Alberta Innovates Health
Solutions
$118,604 / 2 years
Funded in partnership with the Quebec Breast Cancer
Foundation
$120,000/ 2 years
Funded in partnership with the University of Ottawa
Copeland, John
University of Ottawa
CancerResearchSociety.ca
[email protected]
Isoform specific function of the metastatic forming
FMNL2
Page 2 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
Cowan, Kyle
CHEO Research Institute/University of
Ottawa
Pannexin1 and Pannexin3 as New Therapeutic
Targets for Rhabdomyosarcomas.
$117,590 / 2 years
Cox, Michael
University of British Columbia
Targeting PcG complexes in prostate cancer
initiation and neuroendocrine transdifferentiation
$120,000/ 2 years
D'Amours, Damien
Université de Montréal
Roles of polo-like kinases in the cellular response to
DNA damage
$120,000/ 2 years
Dankort, David
McGill University
Identifying and targeting critical Pten proximal genes
in BRAF(V600E) malignant melanoma
$120,000/ 2 years
De Carvalho, Daniel
University Health
Network, Toronto
Use of high throughput functional genomics screen
to identify novel targets for cancer-specific
epigenetic
therapy
De Carvalho, Daniel
University Health
Network, Toronto
CancerResearchSociety.ca
[email protected]
Modelling the colorectal cancer epigenomes
$120,000/ 2 years
$120,000/ 2 years
Page 3 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
Dick, Fred
Western University
Regulation of apoptosis by the retinoblastoma
Protein and E2F1
$120,000/ 2 years
Duchaine, Thomas
McGill University
Moving targets: Differential regulation of PTEN
3’UTR isoforms by microRNAs in cancer.
$119,670 / 2 years
Egan, Sean
Hospital for Sick Children, Toronto
Modeling APOBEC3B, an endogenous mutagenic
enzyme responsible for non-familial breast cancer in
humans
$120,000 / 2 years
Elliott, Bruce
Queen's University Cancer Research Institute
A novel role of ezrin in lymphangiogenesis and lymph $119,468 / 2 years
node metastasis in breast cancer
Elowe, Sabine
Université Laval
Exploring the role of the spindle checkpoint kinase
Mps1 in maintaining genome stability
$120,000 / 2 years
$120,000 / 2 years
Engert, James
McGill University Health Centre
CancerResearchSociety.ca
[email protected]
Gene environment interactions in the development
of cigarette smoking and obesity
Funded by the Cancer Research Society’s EnvironmentCancer FundTM, in partnership with Read for the Cure
Page 4 of 15
2014 Operating Grants Competition Results
Researcher
Ferbeyre, Gerardo
Université de Montréal
Project Title
Low ERK pancreatic cancer cells define a
subpopulation of tumor initiating cells
Funding Details
$120,000 / 2 years
Funded in partnership with the Charlotte Légaré
Memorial Fund.
$119,995 / 2 years
Fujita, Donald
University of Calgary
Use of modified tumor-penetrating peptides to
deliver inhibitory siRNAs to tumors
Funded in partnership with Alberta Innovates Health
Solutions
Ghanekar, Anand
University Health Network,
Toronto
Phenotypic and Transcriptional Characterization
of Tumor-Initiating Cells in Primary Human
Hepatocellular Carcinoma
$120,000 / 2 years
$118,075 / 2 years
Grant, Denis
University of Toronto
CancerResearchSociety.ca
[email protected]
A novel role for cytochrome P4502E1 in the
carcinogenicity of aromatic amines
Funded by the Cancer Research Society’s
Environment-Cancer FundTM, in partnership with Read
for the Cure
Page 5 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
Greer, Peter
Queen's University Cancer
Research Institute
Arpin: A novel regulator of actin branching and
directional cell migration as a potential therapeutic
target in breast cancer
$120,000 / 2 years
Guillemette, Chantal
Université Laval
Function and regulation of a novel metabolic
pathway associated with prognosis and drug
resistance in chronic lymphocytic leukemia
$120,000 / 2 years
Guillemette, Chantal
Université Laval
Targeted metabolomics to discover novel biomarkers
of uterine cancer
$120,000 / 2 years
Haibe-Kains, Benjamin
Princess Margaret Cancer Center
Assessment of biomedical relevance of molecular
subtyping in breast and ovarian cancers
$101,500 / 2 years
$120,000 / 2 years
Hakem, Razq
University Health Network,
Toronto
CancerResearchSociety.ca
[email protected]
Functional interactions of Rnf169 and Rnf168
proteins in cell signalling and cancer
Funded in partnership with the CURE Foundation
Page 6 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
Harder, Keneth
The University of British Columbia
Enhancing anti-tumour immunotherapy by blocking
tumour-induced immunosuppression
$120,000 / 2 years
Hof, Frazer
University of Victoria
Using novel small molecule antagonists to
understand and exploit epigenetic polycomb targets
that drive aggressive, stem-like cancers
$120,000 / 2 years
Holcik, Martin
Children's Hospital of Eastern Ontario
Rersearch Institute
Targeting apoptotic resistance for cancer treatment
$120,000 / 2 years
Ikura, Mitsuhiko University Health
Network, Toronto
Mechanisms of regulation of oncogenic RhoGEF Lfc
$120,000 / 2 years
Jeannotte, Lucie
Centre de recherche sur le cancer de
l'Université Laval
Characterization of the role of the Yin Yang1 (YY1)
transcription factor in pleuropulmonary blastoma
$120,000 / 2 years
Jones, Russell
McGill University
Investigating metabolic checkpoints in colon cancer
$120,000 / 2 years
Koebel, Martin
University of Calgary
The role of thymidylate synthase polymorphism and
expression in ovarian cancer
$45,000 / 1 year
CancerResearchSociety.ca
[email protected]
Page 7 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
Koromilas, Antonis
Lady Davis Institute for Medical ResearchJewish General Hospital
Translational control by Stat1 and its role in cell
survival and resistance to chemotherapies
$120,000 / 2 years
Koti, Madhuri
Queen's University
Role of tumor inflammatory microenvironment in
differential therapeutic response in ovarian cancer
$120,000 / 2 years
Leask, Andrew
University of Western Ontario
Role of matricellular proteins CCN1 and CCN2 in
melanoma metastasis
$113,054 / 2 years
Leyton, Jeffrey
Université de Sherbrooke
An advanced development in targeted radiation
against muscle invasive migrating bladder cancer
cells
Ling, Hong
University of Western Ontario
CancerResearchSociety.ca
[email protected]
Molecular mechanism of translesion DNA synthesis
in carcinogenesis and cancer drug resistance
$120,000 / 2 years
$120,000 / 2 years
Funded by the Cancer Research Society’s
Environment-Cancer FundTM, in partnership with Read
for the Cure
Page 8 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
$120,000 / 2 years
Funded in partnership with Myeloma Canada
Mai, Sabine
University of Manitoba
Genetic profiling of disease progression in myeloma
McAlpine, Jessica
University of British Columbia
Circulating tumour DNA mutations in endometrial
and ovarian cancer patients can be used to guide
clinical management
$119,147 / 2 years
$120,000 / 2 years
McCaffrey, Luke
McGill University
Understanding the benign-to-malignant transition in
breast cancer
Meloche, Sylvain
Institut de recherche en immunologie
et cancer, Université de Montréal
Role of ERK1/2 signaling in the chromosomal
instability and malignant progression of colorectal
cancer
Moon, Nam-Sung
McGill University
Investigating the function of the RB tumor
suppressor protein in epigenetic regulation
CancerResearchSociety.ca
[email protected]
Funded in partnership with the Quebec Breast Cancer
Foundation
$120,000 / 2 years
$120,000 / 2 years
Page 9 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
Mulligan, Lois
Queen's University
Isoform-specific regulation of the RET receptor
tyrosine kinase
$120,000 / 2 years
$120,000 / 2 years
Funded in partnership with Ovarian Cancer Canada
Nelson, Brad
BC Cancer Agency
What proportion of mutations in the ovarian cancer
genome can be recognized by the immune system?
Parks, Robin
Ottawa Hospital Research Institute
Cancer therapy using a combination of oncolytic
adenovirus vector and Smac mimetics
$120,000 / 2 years
Pelletier, Jerry
McGill University
Engineering chromosome translocations to
recapitulate primary events of human cancer
$120,000 / 2 years
Picketts, David
Ottawa Hospital Research Institute
CancerResearchSociety.ca
[email protected]
Defining the mechanisms through which ATRX
represses the alternative lengthening of telomeres
(ALT) pathway
$120,000 / 2 years
Funded in partnership with the
University of Ottawa
Page 10 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
$118,389 / 2 years
Funded in partnership with the Rob Lutterman
Memorial Fund
Pin, Christopher
University of Western Ontario
The role of ATRX in pancreatic cancer
Porter, Lisa
University of Windsor
Resolving the growth properties of glioma stem
cells
$120,000 / 2 years
$120,000 / 2 years
Pugh, Trevor
University Health Network
CancerResearchSociety.ca
[email protected]
Integrated genomic analysis of gastrointestinal and
pancreatic neuroendocrine tumors treated with
mTOR inhibitor therapies
Funded in partnership with Carcinoid
NeuroEndocrine Tumour Society Canada (CNETS)
Page 11 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
$119,988.00 / 2 years
Reilly, Raymond
University of Toronto
High specific activity polymer-amplified radioimmuno
conjugates for treatment of pancreatic cancer
Rivard, Nathalie
Université de Sherbrooke
Understanding the dual nature of SHP-2 tyrosine
phosphatase in colorectal cancer
Funded in partnership with the Rob Lutterman
Memorial Fund
$120,000 / 2 years
$57,650 / 1 year
Funded by the Cancer Research Society’s
Environment-Cancer FundTM, in partnership with Read
for the Cure
Sawka, Annie
University Health
Network, Toronto
CancerResearchSociety.ca
[email protected]
A detailed spatial analysis on contrasting cancer
incidence patterns in thyroid and lung cancer in
Toronto women
Page 12 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
Seth, Arun
Sunnybrook Health Sciences Centre
miRNA signatures predictive of prostate cancer
recurrence and metastasis
$120,000 / 2 years
Swallow, Carol
Lunenfeld-Tanenbaum Research Institute
The role of centriolar proteins in cancer progression
$120,000 / 2 years
Taylor, Michael D
Hospital for Sick Children, Toronto
Defining the subgroup specific epigenetic landscape
of medulloblastoma
$120,000 / 2 years
Teodoro, Jose
McGill University
Role of the G0S2 gene in cancer cachexia.
$120,000 / 2 years
Thibodeau, Jacques
Université de Montréal
Fighting tumours with immunosuppressive cytokines
$120,000 / 2 years
Topisirovic, Ivan
Jewish General Hospital
The role of RACK1/JNK/eEF1A2 mediated
surveillance of newly synthesized polypeptides in
breast cancer
CancerResearchSociety.ca
[email protected]
$119,980 / 2 years
Page 13 of 15
2014 Operating Grants Competition Results
Researcher
Project Title
Funding Details
$120,000 / 2 years
Funded in partnership with Ovarian Cancer Canada
Vanderhyden, Barbara
Ottawa Hospital Research Institute
Role of PAX2 in the etiology of ovarian and fallopian
tube cancers
Vizeacoumar, Franco
University of Saskatchewan
Targeting telomerase by synthetic lethality
$120,000 / 2 years
Wallace, Valerie
University Health Network
Functional analysis of norrie disease protein
signaling in progression of medulloblastoma
$120,000 / 2 years
$120,000 / 2 years
Whyte, Peter
McMaster University
The requirement for Bmi1 in tumour development in
a mouse model of pancreatic cancer
Wong, Shung
Circadian regulation of brain responses after
radiotherapy
Sunnybrook Health Sciences Centre
CancerResearchSociety.ca
[email protected]
Funded in partnership with
Pancreatic Cancer Canada
(PCC/John van Haastrecht
operating grant)
$120,000 / 2 years
Page 14 of 15
2014 Operating Grants Competition Results
Researcher
Zogopoulos, George
The Research Institute of the McGill
University Health Centre
CancerResearchSociety.ca
[email protected]
Project Title
Funding Details
$120,000 / 2 years
Elucidating the Genetics of Pancreatic Cancer
Funded in partnership
with Pancreatic
Cancer Canada
Page 15 of 15