Download International Institute of Nano and Molecular Medicine

International Institute of
Nano and Molecular Medicine
I²NM² is engaged in multifaceted research projects involving the creation of novel boroncontaining materials, devices and agents enhanced by nanotechnology with applications in
medicine, related materials science and beyond. Research highlights include:
FACULTY
M. Frederick Hawthorne, Ph.D.
Director
Mark W. Lee, Jr., Ph.D.
Assistant Director
Satish Jalisatgi, Ph.D.
Director of Research Operations
Development of nano-sized molecular
motors with biomedical applications.
Development of catabolism-resistant
pharmaceuticals based on carborane
surrogate chemistry.
Alexander Safronov, Ph.D.
Research Assistant Professor
Lalit Goswami, Ph.D.
Research Assistant Professor
Design, synthesis and characterization
Yulia Sevryugina, Ph.D.
Research Assistant Professor
Lixin Ma, Ph.D.
Assistant Professor
of new, high-energy materials for energy storage in structural units ranging
from nano dimensional to macroscale.
Molecular Motors
Development of advanced chemical storage systems for
hydrogen storage based upon nanotechnology and hydride chemistry.
Chemical Hydrogen Storage
Boron Neutron Capture Therapy of Cancer
First demonstration of the proof-of-principle for boron
neutron capture therapy of cancer, arthritis and radiation
mediated surgery (BNCT).
Discrete molecular (monodisperse) nanoparticles which
Drug Delivery
carry multiple copies of, or a combination of, diagnostic
and therapeutic agents for cell-specific delivery to malignant cells.
1514 RESEARCH PARK DR. COLUMBIA MO 65211 573-882-7016
WWW.NANOMED.MISSOURI.EDU
Institute Facts
The International Institute
of Nano and Molecular
Medicine (I²NM²) is a new
campus- wi d e res earc h
center dedicated to the
discovery and application
of fundamental and translational medical science
based upon previously
unexplored
chemistry
combined with nanotechnology and the biosciences.
I²NM² will shortly become
the international leader in
the reinvigorated field of
boron neutron capture
therapy (BNCT), a cellselective binary radiation
method for cancer, arthritis and evolving noninvasive surgical protocols. The BNCT program
will be conducted with the
dedicated neutron source
recently constructed at
the University of Missouri
Research
Reactor
(MURR; the most powerful university-based research reactor in the
world) and the use of the
life sciences laboratory of
the Dalton Cardiovascular
Research Center, including small animal facilities.
I²NM² is housed in its own
3 0, 0 0 0 f t ² la b or at o r y
building in Reactor Park
adjacent to the MURR
and the Dalton Cardiovascular Research Center. The building houses
several state of the art
synthetic and analytical
c h em i s t r y l a b or a t or i e s
including
world-class
mass spectrometry facilities and a nuclear magnetic resonance laboratory.
In addition to instituteowned facilities and instrumentation, the center
will have access to several university instrumentation core facilities.
These include additional
NMR instr umentat ion,
including 600 and 800
MHz NMR spectrometers, an electron microscopy facility with SEM,
TEM and atomic force
microscopy center.
The unique strength of
I²NM² is its new approach to medical inventions and its developing
position as the strongest
research facility for the
development of boron
neutron capture therapy
of cancer in the world.
These efforts are supported
by
superbly
equipped laboratories
with great strength in
chemical synthesis coupled with nanoscience,
biological chemistry,
radiation biology and
medicine. I²NM² will truly
serve translational medicine.
The Institute has been
funded by the NIH, DOE,
NSF, and Honeywell. and
shares dual-use research
projects with its subsidiary,
Center for Borane
Technology supported by
the US Army (Picatinny
Arsenal) and partnered
with I 2 NM 2 .
About the Director
Dr. M. Frederick Hawthorne
Fred Hawthorne, Ph.D.,
and founding Director of
the International Institute of Nano and Molecular Medicine, came
to MU from the University of California, Los
Angeles in 2006.
Hawthorne has led in
the creation of the new
field of polyhedral borane
chemistry
(carboranes, polyhedral
borane anions, metallacarboranes and metallaboranes).
These
building blocks are finding use in nanoscience,
biomedicine, catalysis
and materials applications. An ongoing objective is the development of boron neutron
capture therapy of cancer (BNCT) which Hawthorne will continue at
the University of Missouri nuclear reactor
and supporting facilities.
For 32 years, Hawthorne
served as the Editor-inChief
of
Inorganic
Chemistry published by
The American Chemical
Society.
Hawthorne
has been honored by
numerous national and
international
awards,
honorary degrees and
lectureships.
He was
the co-winner of the
King Faisal International
Prize in Science (2003),
the highest scientific
award of the Islamic
world. In 2009 Hawthorne
was
named
Priestley Medalist, the
premier award of the
American Chemical Society. He has published
over 500 peer-reviewed
papers and he holds 35
patents.Drug Delivry
INTERNATIONAL INSTITUTE OF NANO AND MOLECULAR MEDICINE