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Transcript
Working with the Big Bang Boys By the end of the presentation the attendees will be able to: - Discuss the EH requirements for research employees - Identify employee screening requirements for various organisms - Discuss evaluation/treatment of WR incidents Most animals used in research are breed and NOT wild caught – No issue of worms, parasites Exposure maybe to the research or to the specific type of animal University of Pittsburgh one of four centers with BSL 3 level approval University of Pittsburgh one of 23 NHP centers Exceptional care for the animals ◦ Ill animals Development of Animal Exposure Surveillance Program Involvement of Environmental Health and Safety Involvement of a Biosafety Officer Educational level of employees and need for education CONSTANTLY Small ◦ Rodents Large ◦ Sheep, goats ◦ Cows, pigs ◦ Rabbits, NHP ◦ Old world ◦ Macaque ◦ Baboons - - Tissue Organisms related to Rodents ◦ ◦ ◦ ◦ ◦ ◦ ◦ Mice Rats Shews Prairie Dogs Ferrets Gerbils Hamsters – sensory Cancer TB Plague FLU Surgical procedures Genetics and risk factor IBS Spinal cord injury Asthma Aging Drug delivery strategies Sheep Goats Swine Dogs Cats Knee/joint replacement Transplants - lung Huntington Disease Infectious disease Heart valve DM Drug testing Brain/vision studies Baboons Macaques ◦ Rhesus ◦ Cynomolgus New World ◦ Squirrel Monkeys HIV Rabies Metabolic disease CV disease Neurological diseases Polio Space research Behavioral research Tularemia Anthrax Yellow Fever Equine Fever Zika West Nile Small Pox ◦ Monkey pox Rift Valley Botulinum Meningitis Japanese Encephalitis Toxoplasma Malaria Chikungunya Garb No treatment/No vaccines for many Mandatory approved vaccine Non approved vaccines Exclusion with certain disease, medications Baseline/exit blood work All animals are guaranteed upon arrival ◦ Even from breeder If become ill removed from area Rat Fever ◦ Streptobacillus ◦ Penicillin Plague ◦ Examine Brain of animal FLU ◦ Tamiflu Cancer Cells Ringworm Large Bites – suturing Toxoplasmosis Q fever (female) Orf fever Anthrax Rabies Cat bites Pasteurella (rabbits with red eyes) Tularemia (Rabbit fever) Verification animal is “clean” – if not treat what animal has Herpes B ◦ ◦ ◦ ◦ ◦ ◦ Special laboratory NHP examination Bite worse than scratch, close to head worse Numbness of area ---- meningoencephalitis Antiviral medication Follow up with human and Non-human SIV/HIV 2 Strength of animal underestimated Rabies Animals are observed every day ◦ Looking for any open areas ◦ Looking for pain signs Measles ◦ Positive titer NOT just history vaccines TB ◦ Every six month evaluation – both humans and NHP Proactive is better than reactive ◦ ◦ ◦ ◦ ◦ AESP Biosafety involvement CDC Internet resources Other OHN’s -
