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Sickle Cell, The Sticky Cell: 7th Grade Life Science Module Math and Science Partnership Teacher’s Professional Development Workshop McWane Science Center September 19, 2013 Lauren C. Jackson Undergraduate TU Dee Dee Canionero, M.S. Dr. Chastity Bradford, PhD Module Pre-Requisites This module is designed for students with a background knowledge of: • The Central Dogma • Chromosomes and Alleles • The Circulatory System Tuskegee University's Department of Biology • Introduce the Module Using the Five E Model • Students should be able to… Recognize Sickle Cell Anemia as an inherited genetic disorder. Understand the Punnett Square. Relate major organs of circulatory system to their functions. Blood Vessels Deliver Oxygen to the Body Tuskegee University's Department of Biology The Five E Model 1. 2. 3. 4. 5. Engage Explain Explore Elaborate Evaluate Tuskegee University's Department of Biology Engage: Pre-Test Video Tuskegee University's Department of Biology Living with Sickle Cell Anemia This video—presented by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health—shows how Tiffany, a mother and student, has coped with having sickle cell disease. http://youtu.be/qe59ar-GZmg Tuskegee University's Department of Biology Explain: PPT Presentation that Highlights Key Concepts Tuskegee University's Department of Biology The Central Dogma DNA RNA Protein Tuskegee University's Department of Biology Determining Genotype and Traits: Using The Punnett Square Tuskegee University's Department of Biology DNA RNA ? Protein: Building Blocks? Amino Acids Tuskegee University's Department of Biology Amino Acids Tuskegee University's Department of Biology What is the Function of Red Blood Cell ? Carry Oxygen Through Body Tuskegee University's Department of Biology What do Red Blood Cells Travel Through? Blood Vessels Tuskegee University's Department of Biology Circulatory System • The overall function of the • Circulatory System circulatory system is to • Organs: transport blood throughout Heart and Blood Vessels the body. – Arteries – Veins • Blood (Hemoglobin) • Cells: Red Blood Cells Tuskegee University's Department of Biology Protein Shape Function Tuskegee University's Department of Biology The Punnett Shuffle To the right (4x), To the left (4x) Now switch (4x), Now move it down a square (2x) To the right (4x), To the left (4x) That’s it (4x), Now that’s your Punnett Square (2x) Tuskegee University's Department of Biology Elaborate: Review Worksheet Tuskegee University's Department of Biology Sickle Cell Anemia: A serious blood disorder, inherited from both parents, in which the body makes sickle-shaped red blood cells instead of normal shaped red blood cells. Tuskegee University's Department of Biology Evaluate: Post Test Tuskegee University's Department of Biology