Download curriculum vita - Indiana University School of Optometry

Date of Preparation: March1st, 2015
CURRICULUM VITA
1. NAME AND PERSONAL DATA
Name: Chia-Yang Liu, Ph.D.
Date/Place of Birth: October 10th, 1960/Taipei, Taiwan
Citizenship: Naturalized US Citizen
Phone: (513)335-7152
Home Address: 822 N. Woodbridge Dr. Bloomington IN 47408
Current Academic Rank: Associate Professor
Primary Appointment: School of Optometry
2. EDUCATION & EXPERIENCE
09/1979-05/1983, B.S., Taipei Medical University (Taiwan) (Department of Pharmacy)
09/1983-05/1985, M.S., National Taiwan University (Institute of Biochemistry, College of
medicine)
07/1985-05/1987, Lieutenant, Military Service (Republic of China, Taiwan)
06/1987-07/1988, Research Associate, National Taiwan University (Institute of Biochemistry,
College of medicine)
09/1988 -05/1993, Ph.D., University of Cincinnati Medical Center (Interdisciplinary Ph.D.
Program/Molecular Ophthalmology) (Mentor: Winston Kao, Ph.D., Professor and Ophthalmic
research director)
Dissertation: Molecular cloning and identification of mouse cornea-specific Keratin 12 gene.
06/1993-06/1997, Post-doctoral fellow, University of Texas Health Science Center at San
Antonio, Department of Molecular Medicine/Institute of Biotechnology (Mentor: Wen-Hwa Lee,
Ph.D., Professor and Chairman)
Projects:
1, Structure-function analysis of retinoblastoma protein in the transgenic mouse.
2, Generation and characterization of Brca-1 knockout mice.
3. ACADEMIC APPOINTMENT
07/1997-08/2002, Research Assistant Professor, Department of Ophthalmology,
Faculty member of the graduate program of molecular and cellular biology, University of
Cincinnati, College of Medicine
09/2002-06/2005, Assistant Professor, Department of Ophthalmology/Bascom Palmer Eye
Institute, Miller School of Medicine, University of Miami, Florida
01/2003-06/2005, Adjunct Assistant Professor, Department of Cell Biology and Anatomy,
Miller School of Medicine, University of Miami, Florida
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Date of Preparation: March1st, 2015
01/2003-06/2005, Adjunct Assistant Professor, Department of Molecular Pharmacology, Miller
School of Medicine, University of Miami, Florida
01/2003-06/2006, Faculty member, Physiology and Biophysics Ph.D. Program, Miller School
of Medicine, University of Miami, Florida.
07/2005-06/2012, Associate Professor, Department of Ophthalmology, College of Medicine,
University of Cincinnati
07/2012-02/2015, Research Associate Professor (non-tenure track), Department of
Ophthalmology, College of Medicine, University of Cincinnati
09/2010-02/2015,, Faculty member, Neuroscience Graduate Program, College of medicine,
University of Cincinnati
09/2011-02/2015, Faculty member, Physician Scientist (MD & Ph.D.) Graduate Program,
College of medicine, University of Cincinnati
03/2015-present Associate Professor, School of Optometry, Indiana University at Bloomington
4. AWARDS AND HONORS
1992, Honorable mention, 13th Graduate Student Research Forum, University of Cincinnati
1991-1993 Predoctoral Scholarship (Ohio Lions Eye Research Foundation)
1999-2000, Grant-in-Aid Award (Fight for Sight Organization)
2004-2005, Olga Keith Wiess Scholar (Research to Prevent Blindness)
2010-2011, Dean’s bridge funding award, University of Cincinnati College of Medicine
5. MEMBERSHIPS IN PROFESSIONAL ORGANIZATIONS
1992—present, Member, Association for Research in Vision and Ophthalmology (ARVO)
1998—present, Member, American Society of Cell Biology (ASCB)
2001—present, Member, International Ocular Surface Society (IOSS)
2006—present, Member, International Society for Eye Research (ISER)
6. SERVICE
A. Committee Involvement:
2005-present, Committee member for organization of annual emeritus faculty dinner,
college of medicine, University of Cincinnati
B. Professional activities:
1. Guest Speaker in the Department of Anatomy and Cell Biology Seminar Series at the
University of North Dakota School of Medicine (March 31st-April 2nd, 2001)
2. Guest Speaker in the Institute of Biochemistry at the Academic Sinica Taipei Taiwan,
Republic of China (July 2nd, 2001)
3. Invited moderator on Corneal Wound Healing Section (Abstract # 5012-5017) in the
ARVO annual meeting, Fort Lauderdale, Florida (May 4th, 2001)
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Date of Preparation: March1st, 2015
4. Guest Speaker at the Department of Biological Science, SUNY College of Optometry
(April 4th, 2002)
5. Invited moderator on Keratocytes and Corneal Stroma Section (Abstract#2930-2936)
in the ARVO annual meeting, Fort Lauderdale, Florida (May 8th, 2002)
6. Guest Speaker at the Bascom Palmer Eye Institute, University of Miami, Florida (May
15 th, 2002)
7. Invited speaker. Symposium of "Animal models for ocular surface diseases."
International Congress of Eye Research. Sydney, Australia. 29August-3rd September,
2004.
8. Guest Speaker at the College of Pharmacy and Allied Health Professions, St. John’s
University, New York. November 30, 3006
Seminar title:” Molecular Genetics of a Transparent Cornea.”
9. Invited speaker. Symposium of "Animal models for ocular surface diseases."
International Congress of Eye Research. Buenos Aires, Argentina. 29 October -3rd
November, 2006.
10. Invited moderator/speaker, Symposium of "Animal models for ocular surface
diseases." International Congress of Eye Research. Beijing, China. September 24-28,
2008.
11. Invited Speaker, the 15th Japanese Ocular Wound Healing Society Symposium,
Wakayama Japan, Aug21-22, 2010
12. Invited Speaker, 2010-2011 Vanderbilt Eye Institute Academic Seminar Series,
Title: Notch gain-of-function in mouse periocular mesenchyme lead to congenital
blepharophimosis by downregulating FoxL2 transcription factor. December 13th, 2010
13. Invited moderator/speaker, Corneal cell biology symposium at Wakayama,
Title: Role of Notch signaling in ocular glands development and goblet cell
differentiation. Octber28-29, Wakayama, Japan
14. Invited section co-organizer/co-moderator on Corneal morphogenesis and
development in Gordon Research Conference (Biology & Pathobiology of the Cornea)
March 25-30, 2012 Four Points Sheraton /Holiday Inn Express Ventura, CA
15. Invited speaker, 2011-2012 Departmental Seminar Series for Visual Science
Title: Canonical Notch signaling in ocular surface morphogenesis and disease.
April 26-27, 2012, at Department of Ophthalmology and Visual Science, Washington
University in St. Louis.
16. Invited speaker, Symposium of "Cellular and Molecular Mechanisms of Ocular
Surface Morphogenesis during Development and Diseases" International Congress of
Eye Research. Berlin, Germany. July 21-25, 2012.
Title: Conjunctiva Epithelium Differentiation
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17. Invited speaker, 2011-2012 Departmental Seminar Series for Visual Science
Title: Dominant negative Mastermind-1 expression in ocular surface depletes
conjunctival goblet cells and manifests dry eye in the mouse. August 1-2, 2012, at the
Department of Ophthalmology and Visual Science, University of Illinois at Chicago.
18. Invited speaker: The 45th annual meeting of Japanese society for connective tissue
research at the Wakayama Medical University, Wakayama, Japan. June27-28, 2013.
Seminar title: Interaction between Wnt/b-catenin and Bmp-4/mTOR signalings in the
mouse corneal development
19. Invited speaker on Corneal morphogenesis and development in Gordon Research
Conference (Biology & Pathobiology of the Cornea) February 16-21, 2014; Ventura
Beach Marriott, Ventura, CA
20. Invited speaker, CE Seminar Series for Visual Science. Title: Canonical Notch
signaling is indispensable for ocular surface development and homeostasis. August 2829, 2014, at the Indiana University School of Optometry, Bloomington, Indiana.
21. Invited speaker, Scholars in Vision Science lecture. Title: Gene regulatory networks
governing goblet cell differentiation in ocular surface epithelium. January 28-29, 2015, at
the University of Pittsburgh/College of Medicine/Eye and Ear Institute, Pittsburgh, PA
15261.
C. National/International Distinguished Activities: None
D. Editorial Service:
Editorial Review Board member of Molecular Vision (since 2012)
Editorial Review Board member of The Scientific World Journal (since 2011)
International Editorial Board member of Taiwan Journal of Ophthalmology
(since 2011)
Editorial Review Board member of Journal of Ophthalmic Diseases (since 2014)
Editorial Review Board member of International Journal of Ophthalmic Research
(ISSN 2409-5680)(Since 2014/12)
E. Manuscript and Grant reviewer:
o Archive Ophthalmology (1-2/year)
o Biomaterial (1-2/Year)
o Cornea (2-3/year)
o Current Eye Research (1-2/year)
o Developmental Biology (1-2/year)
o Developmental Dynamics (1/year)
o European Journal of Clinic Pathology (1-2/year)
o Experimental Cell Research (1-2/year)
o Experimental Eye Research (4-5/year)
o Expert Review of Ophthalmology (1-2/year)
o International Journal of Molecular Sciences (3-4/year)
o Investigate Ophthalmology & Vision Science (4-5/year)
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o Journal of Biological Chemistry (1-2/year)
o Journal of Cellular and Molecular Medicine (1-2/year)
o Journal of Cell Physiology (1-2/year)
o Journal of Ophthalmology (1-2/year)
o Mechanisms of Development (1-2/year)
o Molecular Vision (4-5/year)
o Ophthalmic Genetics Journal (1-2/year)
o PLOS ONE (1-2 /year)
o The Ocular Surface (1-2/year)
o The Scientific World Journal (4-5/year)
o Translational Vision Science and Technology (1-2/year)
o Tumor Biology (1-2/year)
Invited Grant Review:
o The Welcome Trust's eGrant (1/year, since 2010)
o Fight for Sight research project grant (1/year, since 2012)
o Research Grant Council (RGC) of Hong Kong (1-3/year, since 2009)
o The Netherlands Organisation for Scientific Research (NWO) Vici grant in the
Innovational Research Incentives Scheme (2014)
o NIH Biology of Visual System (BVS) study section at Bethesda, Washington
DC, February 19-20, 2015 (Ad Hoc)
F. Participation in department recruitment activities including resident staff interviewing
Committee: interviewing applicants for lab. research associate (Semin Goins,Sarah Stewart,
Shannon Balser, and JianHua Zhang), postdoct fellow (Yong Yuan, Ph.D.; Mindy Call,
Ph.D.), and junior faculty (Minh-Thanh Nguyen, Ph.D.) in the Edith Crawley Vision research
center
G. Participation in local activities that benefit the institution, e.g., fundraising, quality
assurance, etc.: None
H. Community activities:
2005-present, Youth Sunday School Teacher (Cincinnati Chinese Church)
7. TEACHING
Lecture
1998-2000, 3 hrs Lecture (Biochemistry of the Eye), Ophthalmology Residents core course,
University of Cincinnati Medical Center.
2003-2005, 6 hrs lecture on Human Genetics and 6 hrs lecture on Gene targeting and
transgenesis, IBS 00-100 graduate core course in molecular cellular biology, University of Miami
Miller school of Medicine.
2014, 2hrs lecture (Special Topics), graduate elective course in Pharmacology & Cell
Biophysics, University of Cincinnati Medical Center.
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Date of Preparation: March1st, 2015
Seminar
1997-1999, graduate course (1hr credit) of the program of molecular and cellular biology on
Molecular and Cell Biology Journal Club University of Cincinnati
2hr/week, supervising the first and second year graduate students to present scientific papers.
Graduate student thesis advisor
Trainee: Jie Ouyang MD, Ph.D., 2003-2006, Physiology and Biophysics Ph.D. Program, Miller
School of Medicine, University of Miami, Florida.
Dissertation: Pax6 over-expression suppresses cell proliferation and retards the cell cycle in
corneal epithelial cells
Present position: Pathology residency, Department of Pathology, Mount Sinai School of
Medicine, New York.
Post-graduate training mentor
1. Trainee: Lung-Kung Yeh, MD, Ph.D., 2003-2005, Bascom Palmer Eye Institute/Department of
Ophthalmology, Miller School of Medicine, University of Miami, Florida
Project: Soluble Lumican Glycoprotein Purified from Human Amniotic Membrane Promotes
Corneal Epithelial Wound Healing.
Present position: Assistant Professor, Department of Ophthalmology, Chang Gung Memorial
Hospital, Linkou, Taiwan.
2. Trainee: Yujin Zhang, Ph.D., 2005-present, Department of Ophthalmology, College of
Medicine, University of Cincinnati
Project: Wnt/β-catenin and Notch signaling in mammalian eyelid morphogenesis
3. Trainee: Yong Yuan, Ph.D., 2009-present, Department of Ophthalmology, College of
Medicine, University of Cincinnati
Project: Proteomics and Gene profiling analysis of the mononucleocytes from age-related
macular degeneration. Mouse models for congenital angle closure glaucoma.
Graduate student thesis committee
1. Liang Chen, Pre-doctoral student, Ph.D. program/Environmental Genetics and Molecular
Toxicology/Department of Environmental Health, College of Medicine, University of
Cincinnati (Advisor: Dr. Ying Xia, Ph.D.)
Graduated at January 27th, 2012
Present position: postdoctoral fellow at the University of California San Diego.
2. Poonam Chopra, Pre-doctoral student, Ph.D. program/The James L. Winkle College of
Pharmacy, University of Cincinnati (Advisor: Dr. Kevin Li, Ph.D.)
3. Qinghang Meng, Pre-doctoral student, Ph.D. program/Environmental Genetics and
Molecular Toxicology/Department of Environmental Health, College of Medicine,
University of Cincinnati (Advisor: Dr. Ying Xia, Ph.D.)
Summer Undergraduate Research Forum (SURF) training mentor
1. Ian Han, June-August, 2001
Project: Molecular cloning of mouse Angiopoietin-like factor-6.
Present position: Third year residence in Wilmer Eye Institute/Department of
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Ophthalmology at the Johns Hopkins Bayview Medical Center.
2. Tyler Kochel, June - August, 2008
Project: β-catenin is required for mediating FGF-7-induced ocular surface squamous
neoplasia in mice.
Present position: Graduate Student (Ph.D. program) in the Department of Molecular
genetics, University of Maryland
3. Jeffrey Miller, June-August, 2009
Project: Conditional overexpression of TGF-α in adult mice corneal epithelium causes
cornea inflammation and plateau iris
Present position: Medical Student at the Ohio State University
4. Oliver Lam, June-August, 2010
Project: Essentiality of Canonical Notch signaling in ocular surface glands development
and conjunctival goblet cell differentiation.
Present position: Undergraduate student (3rd year) in the Developmental biology at the
University of Michigan, An Arbor.
5. Gracia Ng, June-August, 2012
Project: Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial
stratification.
Present position: 1st year in the MD/PhD program at the Ohio State University
8. RESEARCH
A. Peer reviewed Grants
1.
Fight For Sight Grant-In-Aid
Project Title: Functional Analysis and Promoter Characterization of the Mouse
Keratocan Gene
Total amount: $11,000 (08/01/98-02/01/99)
Role: Principal Investigator
2.
NEI/NIH RO1 EY12486
Project Title: Role of Keratocan in Corneal Biology
Annual Direct Cost: $175,000 (02/01/2001~01/31/2009)
Role: Principal Investigator (70%)
3.
NEI/NIH 5 R01 EY012486-09 (ARRA)
Project Title: Role of Keratocan in Corneal Biology
Annual Direct Cost: $ 250,000 (09/01/2009~08/31/2011)
Role: Principal Investigator (70%)
4.
NIH/NEI, RO1 EY011845.
Project Title: Structure function relationship of lumican/PI: Dr. Winston W.-Y. Kao
(University of Cincinnati)
Annual Direct Cost: $250,000 (07/01/07~06/30/2012)
Role : Co-PI (5%)
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Date of Preparation: March1st, 2015
5.
NEI/NIH RO1 EY 03890 subcontract from the University of Illinois at Chicago
Project Title: Biochemcal Basis of Keratoconus/PI: Dr. Bretrice Yue
Annual Direct Cost: $46,477 (07/01/2003~06/30/2008)
Role: Principal Investigator at University of Cincinnati (5%)
6.
NIH/NEI RO1 EY012651-09
Project Title: Maintenance of ocular surface integrity/PI: M. Elizabeth Fini (University of
Miami)
Annual Direct Cost: $ 200,000 (08/01/2003~07/31/2007)
Role: Co-PI (20%)
7.
NIH/NEI RO1 EY021501
Title: Mouse model for eyelid disease: congenital blepharophimosis
Annual Direct Cost: $ 250,000 (09/01/2011~08/31/2016)
Role: Principal Investigator (70%)
8.
NIH/NEI R21EY024409
Title: RNA Nanoparticles for Ocular Drug Delivery to the Posterior Eye /Principal
Investigator: Kevin S Li, PHD (University of Cincinnati College of Pharmacy)
Annual Direct Cost: $247,753 (12/02/2014-11/30/2016)
Role : Co-Investigator (5%)
9.
Sponsor Award Number: WU-12-197 to University of Cincinnati
Prime Sponsor NIH/NEI 5R01EY017609 to Dr. Andrew Huang, M.D. at Washington
University in St. Louis.
Project Title: Mouse model for human genetic corneal stromal dystrophy
Annual Direct Cost: $ 75,000 (3/1/2012~2/28/2013)
Role : Principal Investigator (PI) at University of Cincinnati
B. Peer reviewed articles.
Publications in Peer-Reviewed Journals
1. Chia-Yang Liu, Bjorn R. Olsen, and Winston W.-Y. Kao (1993). Developmental Patterns
of two α1(IX) collagen mRNA isoforms in mouse. Developmental Dynamics 198: 150-157.
PMID: 8305707
2. Chia-Yang Liu, Guang Zhu, Andrea Weasterhausen-Larsen, Richard Converse,
Candace Kao, Tung-Tien Sun and Winston W.-Y. Kao (1993). Cornea-Specific Expression
of K12 Keratin during mouse development. Current Eye Research 12: 963- 974. PMID:
7508359
3. Chia-Yang Liu, Guang Zhu, Richard Converse, Candace W.-C. Kao, Hiroshi Nakamura,
Scheffer C.-G. Tseng, Mei-Mei Mui, Jerome Seyer, Monica J Justice,Mary E. Stech, Gwenn
M. Hansen, and Winston W.-Y. Kao. (1994) Characterization and Chromosomal Localization
of the Cornea-Specific MurineK12 keratin gene Krt1.12. J. Biol. Chem. 269:24627-24636.
PMID: 7523376
4. Willie Y. W. Chen, Mei Mei Mui, Winston W.-Y. Kao, Chia-Yang Liu, and Scheffer C.G
Tseng (1994) Conjunctival Epithelial Cells do not Transdifferentiatein Organotypic Cultures:
Expression of K12 Keratin is Restricted to Corneal Epithelium. Current Eye Research 13:
65-778. PMID: 7531131
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Date of Preparation: March1st, 2015
5. Jim L. Funderburgh, Martha L. Funderburgh, Nathanael A. Hevelone, Mary E.Stech,
Monica J. Justice, Chia-Yang Liu, Winston W.-Y. Kao and Gary W. Conrad. (1995)
Sequence, Molecular Properties, and Chromosomal Mapping ofMouse Lumican. Invest.
Ophthal. & Vis. Sci. 36 (11): 2296-2303. PMID: 7558724
6. Xueliang Zhu, Michael A. Mancini, Kai-Hsuan Chang, Chia-Yang Liu, Chi-Fen Chen, Bei
Shan, Diane Jones, Teresa L. Yang-Feng, and Wen-Hwa Lee (1995) Characterization of a
novel 350 kd nuclear phosphoprotein specifically involved in mitotic phase progression.
Molecular and Cellular Biology 15(9): 5017-5029. PMID: 7651420
7. Chia-Yang Liu, Andrea Fleskin-Nikitin, Shang Li, Yingying Zeng, and Wen-Hwa Lee
(1996) Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the
egg cynlinder in early postimplantation development. Genes & Development 10: 1835-1843.
PMID: 8698242
8. Winston W.-Y. Kao, Chia-Yang Liu, Richard L. Converse, Atsushi Shiraishi, Candace,
W.-C. Kao, Masamichi Ishizaki, Thomas Doetschman and John Duffy.(1996) Keratin 12
deficient mice with epithelial erosion. Invest. Ophthal. & Vis. Sci. 37(13): 2572-2584. PMID:
8977471
9. Daniel J. Riley∗, Chia-Yang Liu ∗, and Wen-Hwa Lee (1997) The N-terminal Region of
the Retinoblastoma Protein Is Essential for Growth Retardation, Embryonic Development,
and Tumor Suppression. Molecular and Cellular Biology 17(12): 7342-7352. PMID: 9372965
∗ Equal first author
10. Chia-Yang Liu, Atsushi Shiraishi, Candace W.-C. Kao, Richard L. Converse, James L.
Funderburgh, L.M. Corpuz, G.W. Conrad, and Winston W.-Y. Kao (1998) The Cloning of
Mouse Keratocan cDNA and Genomic DNA and the Characterization of Its Expression
During Eye Development. J. Biol. Chem.273:22584-22588. PMID: 9712886
11. Atsushi Shiraishi, Richard L. Converse, Chia-Yang Liu, Fang Zhou, CandaceW.-C.Kao,
and Winston W.-Y. Kao (1998) Identification of the Cornea-SpecificKeratin 12 Promoter by
In Vivo Particle-Mediated Gene Transfer. Invest.Ophthalmol. Vis. Sci. 39:2554-2561. PMID:
9856765
12. Shizuya Saika, Atsushi Shiraishi, Chia-Yang Liu, Satoko Saika, Candace Kao, and
Winston W.-Y. Kao (2000) Role of Lumican in the Corneal Epithelium During Wound
Healing. J. Biol. Chem.275: 2607-2612. PMID: 10644720
13. Chia-Yang Liu, Hisham Arar, Candace Kao, and Winston W.-Y. Kao (2000)
Identification of A 3.2 KB Cornea-Specific Murine Keratocan Promoter in the Adult
Transgenic Mice. Gene 250: 85-96. PMID: 10854782
14. Judy Grover, Chia-Yang Liu, Winston W.-Y. Kao, and Peter J. Roughley (2000)
Analysis of the Human Lumican Gene Promoter. J. Biol. Chem. 275: 40967-40973. PMID:
11016924
15. Robert Gendron, Chia-Yang Liu, Helene Paradis, Lisa C. Adams, and Winsto W.-Y.
Kao. (2001) MK/T-1, an immortalized fibroblast cell line derived using cultures of mouse
corneal stroma. Molecular Vision 7:107-13. PMID: 11344338
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Date of Preparation: March1st, 2015
16. I-Jong Wang, Candace W.-C. Kao, Chia-Yang Liu, Shizuya Saika, Patsy M. Nishina,
John P. Sundberg, Richard S. Smith, and Winston W.-Y. Kao (2001) Characterization of
Corn1 Mice: Alteration of Epithelial Cell Gene Expression Molecular Vision 7:20-26. PMID:
11182022
17. Shizuya Saika, Satoko Saika, Chia-Yang Liu, Candace Kao, Azar Muhamad, Philip
Sanford, Thomas Doetschman, and Winston W.-Y. Kao. (2001) TGFbeta2 in corneal
morphogenesis during mouse embryonic development. Developmental Biology 240: 419432. PMID: 11784073
18. I-Jong Wang, Eric C. Carlson, Chia-Yang Liu, Candace W.-C. Kao, Fung-Rong Hu,
and Winston W.-Y. Kao. (2002) Cis-regulatory elements of the mouse Krt1.12 gene.
Molecular Vision 8: 94-101. PMID: 11951085
19. Barbe.A. Austin, Christopher Coulon, Chia-Yang Liu, Winston.W.-Y. Kao, andJody.A.
Rada.(2002) Altered Collagen Fibril Formation in the Sclera of Lumican-Deficiency Mice.
Invest. Ophthalmol. Vis. Sci. 43:1695-1701. PMID: 12036967
20. Nikitin AY, Chia-Yang Liu, Flesken-Nikitin A, Chen CF, Chen PL, Lee WH. (2002) Cell
lineage-specific effects associated with multiple deficiencies of tumorsusceptibility genes in
Msh2(-/-)Rb(+/-) mice. Cancer Res. 62:5134-8. PMID: 12234974
21. Helene Paradis, Chia-Yang Liu, Shizuya Saika , Azar Muhamad, ThomasDoetschman,
W. Good, R. Nayak, N. Laver, Candace Kao, and Winston W.-Y. Kao. Robert Gendron.
(2002) Tubedown-1 in remodeling of the developing vitreal vasculature in vivo and
regulation of capillary outgrowth in vitro. Developmental Biology 249:140-155. PMID:
12217325
22. Eric C. Carlson, Kazuhisa Mamiya, Chia-Yang Liu, Robert L. Gendron, David E. Birk,
James L. Funderburgh, and Winston W-Y. Kao. (2003) Role of 41Cys in the N-terminal
Domain of Lumican in Ex Vivo Collagen Fibrillogenesis by Cultured Corneal Stromal Cells.
Biochem J. 369:461-8. PMID: 12381269
23. Carlson EC, Wang IJ, Chia-Yang Liu, Brannan P, Kao CW, Kao WW. (2003) Altered
KSPG expression by keratocytes following corneal injury. Mol Vis. 9:615-623. PMID:
14654769
24. C.-Y. Liu∗, D. E. Birk, J. R. Hassell, B. Kane, and W. W.-Y. Kao (2003) Keratocandeficient mice display alterations in corneal structure. J. Biol. Chem. 278:21672-7. PMID:
12665512 ∗: Corresponding Author
25. Meek KM, Quantock AJ, Boote C, Chia-Yang Liu, Kao WW. (2003) An X-ray scattering
investigation of corneal structure in keratocan-deficient mice. Matrix Biol. 22:467-75. PMID:
14667839
26. L. Zhang, W. Wang, Y. Hayashi, J. V.Jester, D. E.Birk, M. Gao, Chia-Yang Liu, W. W.Y.Kao, M. Karin and Y. Xia (2003) A role for MEKK1 in TGF-beta/activin-induced epithelium
movement and embryonic eyelid closure. The EMBO J. 22:4443-4454. PMID: 12941696
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Date of Preparation: March1st, 2015
27. E. Espana, He Hua, T. Kawakita, M. Pascuale, V. K. Raju, C.-Y. Liu, and S. C. G.
Tseng. (2003) Human keratocytes cultured on amniotic membrane stroma preserve
morphology and express keratocan. Invest Ophthalmol Vis Sci. 44:5136-5141. PMID:
14638709
28. Espana EM, Kawakita T, Romano A, Di Pascuale M, Smiddy R, Chia-Yang Liu, Tseng
SC. (2003) Stromal niche controls the plasticity of limbal and corneal epithelial differentiation
in a rabbit model of recombined tissue. Invest Ophthalmol Vis Sci. 44:5130-5. PMID:
14638708
29. Tanaka T, Saika S, Ohnishi Y, Ooshima A, McAvoy JW, Chia-Yang Liu, Azhar M,
Doetschman T, Kao WW. (2004) Fibroblast growth factor 2: roles of regulation of lens cell
proliferation and epithelial-mesenchymal transition in response to injury. Mol Vis. 10:462-7.
PMID: 15273655
30. Carlson EC, Chia-Yang Liu, Yang X, Gregory M, Ksander B, Drazba J, Perez VL.(2004)
In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector
and keratocyte-specific promoter. Invest Ophthalmol Vis Sci. 45:2194-2200. PMID:
15223795
31. Espana EM, Kawakita T, Chia-Yang Liu, Tseng SC.(2004) CD-34 expression by
cultured human keratocytes is downregulated during myofibroblast differentiation induced
by TGF-beta1. Invest Ophthalmol Vis Sci. 45:2985-2991. PMID: 15326111
32. Saika S, Okada Y, Miya T, Yamanaka O, Ohnishi Y, Oshima A, Chia-Yang Liu, Weng
D, Kao WW.(2004) Role of p38 MAP kinase in regulation of cell migration and proliferation
in healing corneal epithelium. Invest Ophthalmol Vis Sci. 45:100-109. PMID: 14691160
33. Saika S, Kono-Saika S, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Flanders KC, Yoo
J, Anzano M, C.-Y. Liu, Kao WW, Roberts AB. (2004) Smad3 signaling is required for
epithelial-mesenchymal transition of lens epithelium after injury. Am J Pathol. 164:651-63.
PMID: 14742269
34. Tetsuya Kawakita, Edgar M. Espana, Hua He, Lung-Kun Yeh, Chia-Yang Liu, and
Scheffer C. G. Tseng (2004) Calcium-Induced Abnormal Epidermal-like Differentiation in
Cultures of Mouse Corneal-Limbal Epithelial Cells Invest Ophthalmol Vis Sci 45: 3507-3512.
PMID: 15452056
35. Johan Holmberg, Chia-Yang Liu, and Tord Hjalt (2004) PITX2 gain-of-function in Rieger
syndrome eye model. Am J Pathol. 165:1633-1641. PMID: 15509533
36. Yasuhito Hayashi, Chia-Yang Liu, James J. Jester, Miyuki Hayashi, I-Jong Wang,
James L. Funderburgh, Shizuya Saika, Peter J. Roughley, Candace Whei-Cheng Kao CW-C
and Winston Whei-Yang Kao (2005) Excess Biglycan Interferes with TGFα Signaling
Required for Eyelid Morphogenesis. Developmental Biolology. 277:222-234. PMID:
15572151
37. Lung-Kun Yeh, Wei-Li Chen, Wei Li, Edgar M. Espana, Jie Ouyang, Tetsuya Kawakita,
Winston W.-Y. Kao, Scheffer C.G. Tseng, and Chia-Yang Liu ∗ (2005) Soluble Lumican
Glycoprotein Purified from Human Amniotic Membrane Promotes Corneal Epithelial Wound
Healing. Invest Ophthalmol Vis Sci. 46:479-86. PMID: 15671272. ∗: Corresponding Author
11
Date of Preparation: March1st, 2015
38. Kawakita T, Espana EM, He H, Hornia A, Yeh LK, Ouyang J, Chia-Yang Liu, Tseng
SCG (2005) Kera expression of murine keratocytes is maintained on amniotic membrane by
down-regulating transforming growth factor-beta signaling. J Biol Chem.280, 27085-27092.
PMID: 15908433
39. Chikama T, Hayashi Y, Chia-Yang Liu, Terai N, Terai K, Kao CW, Wang L, Hayashi M,
Nishida T, Sanford P, Doestchman T, Kao WW. (2005) Characterization of tetracyclineinducible bitransgenic Krt12rtTA/+/tet-O-LacZ mice. Invest Ophthalmol Vis Sci. 46:1966-72.
PMID: 15914610
40. Carlson EC, Chia-Yang Liu, Chikama T, Hayashi Y, Kao CW, Birk DE, Funderburgh JL,
Jester JV, Kao WW. (2005) Keratocan, a cornea-specific keratan sulfate proteoglycan, is
regulated by lumican. J Biol Chem. 280:25541-7. PMID: 15849191
41. Hayashi M, Hayashi Y, Chia-Yang Liu, Tichelaar JW, Kao WW. (2005) Over expression
of FGF7 enhances cell proliferation but fails to cause pathology in corneal epithelium of
Kerapr-rtTA/FGF7 bitransgenic mice. Mol Vis. 11:201-207. PMID: 15788998
42. Kawakita T, Espana EM, He H, Li W, Chia-Yang Liu, Tseng SC. (2005) Intrastromal
invasion by limbal epithelial cells is mediated by epithelial-mesenchymal transition activated
by air exposure. Am J Pathol. 167:381-93. PMID: 16049325
43. Espana EM, Kawakita T, Di Pascuale MA, Li W, Yeh LK, Parel JM, Chia-Yang Liu,
Tseng SC. (2005) The heterogeneous murine corneal stromal cell populations in vitro.
Invest Ophthalmol Vis Sci. 46:4528-4535. PMID: 16303944
44. Tetsuya Kawakita, Edgar M. Espana, Hua He, Robert Smiddy, Jean-Marie Parel, ChiaYang Liu, and Scheffer C. G. Tseng (2006) Preservation and Expansion of Primate
Keratocyte Phenotype by Downregulating TGF-β Signaling in a Low Calcium Serum-free
Medium Invest Ophthalmol Vis Sci. 47(5):1918-1927. PMID: 16638999
45. Jie Ouyang, Ying-Cheng Shen, Lung-Kun Yeh, Wei Li, Brad M. Coyle, Chia-Yang Liu ∗,
and M. Elizabeth Fini∗ (2006) Pax6 Over-expression Suppresses Cell Proliferation and
Retards the Cell Cycle in Corneal Epithelial Cells Invest Ophthalmol Vis Sci. 6:2397-2407.
PMID: 16723449 ∗: co-senior author
46. Tong, YC, Chang SF, Chia-Yang Liu, Kao, WW, Huang CH, and Liaw, J. (2007) Eye
drop delivery of nano-polymeric micelle formulated genes with cornea-specific promoters. J
Gene Medicine 9: 956-966. PMID: 17724775
47. Meij, JTA, Carlson, EC, Wang, L, Chia-Yang Liu, Jester, JV, Birk, DE, and Kao WWY
(2007) Targeted expression of a lumican transgene rescues corneal deficiencies in lumicannull mice. Molecular Vision 13:2012-2018. PMID: 17982425
48. Carlson EC, Lin M, Chia-Yang Liu, Kao WW, Perez VL, Pearlman E. (2007) Keratocan
and lumican regulate neutrophil infiltration and corneal clarity in LPS-induced keratitis by
direct interaction with KC/CXCL1. J. Biol. Chem. 282:35502-35509. PMID: 17911102
12
Date of Preparation: March1st, 2015
49. Yeh LK, Chia-Yang Liu, Chien CL, Converse RL, Kao WW, Chen MS, Hsieh FJ, Wang
IJ.(2008) Molecular analysis and characterization of zebrafish keratocan (zKera) gene. J
Biol Chem. 283:506-517. PMID: 17965408
50. Chen, Chun-Chen, Yeh, Lung-Kun, Chia-Yang Liu, Kao, Winston W. -Y. Kao, John R.,
Lin, Shing-Jong, Hu, Fung-Rong and Wang, I-Jong (2008) Morphological Differences
between the Trabecular Meshworks of Zebrafish and Mammals, Current Eye Research,
33:1,59 -72. PMID: 18214743
51. W Li, Y-T Chen, Y Hayashi, G Blanco, A Kheirkah, H He, S-Y Chen, Chia-Yang Liu and
SCG Tseng (2008) Down-regulation of Pax6 is associated with abnormal differentiation of
corneal epithelial cells in severe ocular surface diseases. Journal of Pathology; 214:114122. PMID: 18027901
52. Tai-ichiro Chikama, Chia-Yang Liu ∗, Johanna T.A. Meij, Yasuhito Hayashi, I-Jong
Wang, Liu Yang, Teruo Nishida, and Winston W.Y. Kao∗ (2008) Excess FGF-7 in Corneal
Epithelium Causes Corneal Intraepithelial Neoplasia in Young Mice and Epithelium
Hyperplasia in Adult Mice. Am J Pathol 172: 638-649. PMID: 18276784 ∗:corresponding
author
53. Hao J, Li SK, Chia-Yang Liu, Kao WW. (2009) Electrically assisted delivery of
macromolecules into the corneal epithelium. Exp Eye Res. 89:934-41. Epub 2009 Aug
12.PMID: 19682448
54. Zhang Y, Call MK, Yeh LK, Liu H, Kochel T, Wang IJ, Chu PH, Taketo MM, Jester JV,
Kao WW, Chia-Yang Liu ∗. (2010) Aberrant expression of a beta-catenin gain-of-function
mutant induces hyperplastic transformation in the mouse cornea. J Cell Sci. 123:1285-94.
PMID: 20332116 ∗:corresponding author
55. YC Tong, SF Chang, WWY Kao, Chia-Yang Liu, J Liaw. (2010) Polymeric micelle gene
delivery of bcl-xL via eye drop reduced corneal apoptosis following epithelial debridement. J
Control Rel. 147: 76–83. PMID: 20600407.
56. Yeh LK, Chia-Yang Liu, Kao WW, Huang CJ, Hu FR, Chien CL, Wang IJ. (2010)
Knockdown of zebrafish lumican gene (zlum) causes scleral thinning and increased size of
scleral coats. J Biol Chem. 285:28141-55. PMID: 20551313
57. Liu H, Zhang J, Chia-Yang Liu, Wang IJ, Sieber M, Chang J, Jester JV, Kao WW.
(2010) Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells:
lumican null mice. PLoS One. 5(5):e10707.PMID: 20502663
58. Carlson EC, Sun Y, Auletta J, Kao WW, Chia-Yang Liu, Perez VL, Pearlman E. (2010)
Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate
proteoglycans as a model for breakdown of the chemokine gradient. J Leukoc Biol. 88:51722. PMID: 20495072
59. Wang I-J, Huang M-C, Chen Y-H, Yeh L-K, Chia-Yang Liu, et al. (2010) Chitosan
Modification of Adenovirus to Modify Transfection Efficiency in Bovine Corneal Epithelial
Cells. PLoS ONE 5(8): e12085. PMID: 20711466
13
Date of Preparation: March1st, 2015
60. Yasuhito Hayashi, Mindy K. Call, Tai-ichiro Chikama, Hongshan Liu, Eric C. Carlson,
Yan Sun, Eric Pearlman, James L. Funderburgh, George Babcock, Chia-Yang Liu, Yuichi
Ohashi, and Winston W.-Y. Kao. (2010) Lumican is required for neutrophil extravasation
following corneal injury and wound healing J. Cell Sci. 123:2987-95. PMID: 20699360
61. Hayashi Y, Call MK, Chia-Yang Liu, Hayashi M, Babcock G, Ohashi Y, Kao WW. (2010)
Monoallelic Expression of Krt12 Gene during Corneal-type Epithelium Differentiation of
Limbal Stem Cells. Invest Ophthalmol Vis Sci.51:4562-8. PMID: 20393120
62. Nien CJ, Massei S, Lin G, Liu H, Paugh JR, Chia-Yang Liu, Kao WW, Brown DJ, Jester
JV. (2010) The development of meibomian glands in mice. Mol Vis. 16:1132-40.PMID:
20664693
63. Yeh JT, Yeh LK, Jung SM, Chang TJ, Wu HH, Shiu TF, Chia-Yang Liu, Kao WW, Chu
PH. (2010) Impaired Skin Wound Healing in Lumican-null Mice. Br J Dermatol. 163:11741180. PMID: 20738297
64. Zhang Y, Kao WW, Pelosi E, Schlessinger D, Chia-Yang Liu ∗. (2011) Notch gain of
function in mouse periocular mesenchyme downregulates FoxL2 and impairs eyelid levator
muscle formation, leading to congenital blepharophimosis. J Cell Sci. 124:2561-2572. PMID:
21730020 ∗: corresponding author
65. Terai K, Call MK, Liu H, Saika S, Chia-Yang Liu, Hayashi Y, Chikama T, Zhang J, Terai
N, Kao CW, Kao WW. (2011) Crosstalk between TGF-beta and MAPK signaling during
corneal wound healing. Invest Ophthalmol Vis Sci. 52:8208-8215. PMID: 21917935
66. Liu H, Zhang J, Chia-Yang Liu, Hayashi Y, Kao WW. (2012) Bone marrow
mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype. J Cell
Mol Med. 16 (5):1114-1124. PMID: 21883890
67. Chia-Yang Liu, Kao WW. (2012) Lumican promotes corneal epithelial wound healing.
Methods Mol Biol. 836:285-90. PMID: 22252641
68. Wu YC, Chia-Yang Liu, Chen YH, Chen RF, Sun TT, Huang CJ, Wang IJ (2012). Blood
vessel epicardial substance (BVES) regulates epidermal tight junction integrity through
atypical protein kinase C. J Biol Chem. 287: 39887-39897. PMID: 23019331
69. Chia-Yang Liu (2012) Wakayama Symposium: Notch-FoxL2-α-SMA Axis in Eyelid
Levator Muscle Development and Congenital Blepharophimosis. Ocul Surf.10:221-223.
PMID: 23084143
70. Yujin Zhang, Oliver Lam, Minh-Thanh T. Nguyen, Gracia Ng, Warren S. Pear, Walden Ai,
I-Jong Wang, Winston W.-Y. Kao, Chia-Yang Liu∗ (2013) Mastermind-like 1 mediated
Notch signaling is indispensable for maintenance of conjunctival epithelial identity.
Development 140, 594-605. PMID: 23293291 ∗: corresponding author
71. Yong Yuan∗, Lung-Kun Yeh, Hongshan Liu, Osamu Yamanaka, William D. Hardie, and
Winston W.-Y. Kao, Chia-Yang Liu∗ (2013) Targeted Overexpression of TGF-α in the
corneal epithelium induces changes in anterior segment morphology and activates Noncanonical Wnt signaling. Invest Ophthalmol Vis. Sci. 54:1829-1837. PMID: 23412089
14
Date of Preparation: March1st, 2015
∗: corresponding author
72. Yong Yuan, Call MK, Yuan Y, Zhang Y, Fischesser K, Chia-Yang Liu, and Winston W.Y. Kao (2013) Dexamethasone induces cross-linked actin networks in trabecular meshwork
cells through noncanonical wnt signaling. Invest Ophthalmol Vis Sci. 54:6502-6509. PMID:
23963164
73. Gracia Y. Ng, Lung-Kun Yeh, Yujin Zhang, HongShan Liu, Gen-Sheng Feng, Winston
W. Y. Kao, and Chia-Yang Liu∗ (2013) Role of SH2-Containing Tyrosine Phosphatase
Shp2 in Mouse Corneal Epithelial Stratification. Invest Ophthalmol Vis Sci. 54:7933-7942.
PMID: 24204042 ∗: corresponding author
74. Osamu Yamanaka ,Yong Yuan,Vivien Jane Coulson-Thomas,Tarsis Ferreira Gesteira,
Mindy K. Call, Yujin Zhang, Jianhua Zhang, Shao-Hsuan Chang, Changchun Xie, ChiaYang Liu, Shizuya Saika, James V. Jester, Winston W-Y Kao (2013) Lumican Binds ALK5
to
Promote
Epithelium
Wound
Healing.
PLoS
ONE
8(12):
e82730.
doi:10.1371/journal.pone.0082730
75. Yu-Ching Wu, Ruei-Feng Chen, Chia-Yang Liu, Fung Rong Hu, Chang-Jen Huang, and
I-Jong Wang (2014) Knockdown of Zebrafish Blood Vessel Epicardial Substance Results in
Incomplete Retinal Lamination. The Scientific World Journal, vol. 2014, Article ID 803718, 9
pages, 2014. doi:10.1155/2014/803718.
76. Feng L, Li SK, Liu H, Chia-Yang Liu, Lasance K, Haque F, Shu D, Guo P.(2014) Ocular
Delivery of pRNA Nanoparticles: Distribution and Clearance After Subconjunctival Injection.
Pharm Res. 31:1046-1058. PMID: 24297069
77. Heather A. McCauley, Chia-Yang Liu, Aria C. Attia, Kathryn A. Wikenheiser-Brokamp,
Yujin Zhang, Jeffrey A. Whitsett, and Géraldine Guasch (2014) TGFβ signaling inhibits
goblet cell differentiation via SPDEF in conjunctival epithelium. Development 141: 46284639. PMID: 25377551
78. Meng Q, Mongan M, Carreira V, Kurita H, Chia-Yang Liu, Kao W, Xia Y. (2014) Eyelid
closure in embryogenesis is required for ocular adnexa development. Invest Ophthalmol Vis
Sci. 55:7652-7661. PMID: 25377219
79. Yang D, Sun YY, Bhaumik SK, Li Y, Baumann JM, Lin X, Zhang Y, Lin SH, Dunn RS,
Chia-Yang Liu, Shie FS, Lee YH, Wills-Karp M, Chougnet CA, Kallapur SG, Lewkowich IP,
Lindquist DM, Murali-Krishna K, Kuan CY. (2014) Blocking lymphocyte trafficking with
FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J
Neurosci. 34:16467-16481. PMID: 25471584
80. Byun YS, Tibrewal S, Kim E, Yco L, Sarkar J, Ivanir Y, Chia-Yang Liu, Sano CM, Jain
S. (2014) Keratocytes derived from spheroid culture of corneal stromal cells resemble tissue
resident keratocytes. PLoS One. 9(11):e112781. PMID: 25471584
C. Quality review of publications
15
Date of Preparation: March1st, 2015
1. Chia-Yang Liu, G. Zhu, R. Converse, C. W.-C. Kao, H. Nakamura, S. C.-G. Tseng, M.M. Mui, J. Seyer, M. J Justice, M. E. Stech, G. M. Hansen, and W. W.-Y. Kao. (1994).
Characterization and chromosomal localization of the cornea-specific murine K12 keratin
gene Krt1.12. J. Biol. Chem. 269: 24627-36. PMID: 7523376
Significance: Isolation and characterization of mouse Krt1.12, the first corneal epitheliumspecific gene.
Cited 4 times in the last five years
Li W, He H, Kuo CL, Gao Y, Kawakita T, Tseng SC. (2006) Basement membrane
dissolution and reassembly by limbal corneal epithelial cells expanded on amniotic
membrane. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2381-9.PMID: 16723447
Kayama M, Kurokawa MS, Ueno H, Suzuki N. (2007) Recent advances in corneal
regeneration and possible application of embryonic stem cell-derived corneal epithelial
cells. Clin Ophthalmol.1(4):373-82.PMID: 19668514
Li W, Hayashida Y, Chen YT, He H, Tseng DY, Alonso M, Chen SY, Xi X, Tseng SC.
(2008) Air exposure induced squamous metaplasia of human limbal epithelium. Invest
Ophthalmol Vis Sci. Jan;49(1):154-62.PMID: 18172087
Kawakita T, Shimmura S, Higa K, Espana EM, He H, Shimazaki J, Tsubota K, Tseng
SC. (2009) Greater growth potential of p63-positive epithelial cell clusters maintained in
human limbal epithelial sheets. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4611-7.
Epub 2009 Mar 25.PMID: 19324845
2. W. W.-Y. Kao, Chia-Yang Liu, R. L. Converse, A. Shiraishi, C., W.-C. Kao, M. Ishizaki, T.
Doetschman and J. Duffy. (1996). Keratin 12 deficient mice with epithelial erosion. Invest.
Ophthal. & Vis. Sci. 37: 2572-84. PMID: 8977471
Significance: Establishment of Krt1.12 knockout mice, demonstration of indispensability of
K12 in corneal epithelial integriety, and association between K12 mutation and Meesman’s
corneal dystrophy.
Cited 7 times in the last five years
Swamynathan SK, Katz JP, Kaestner KH, Ashery-Padan R, Crawford MA, Piatigorsky J.
(2007) Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility,
stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol. 2007 Jan;27(1):18294. Epub 2006 Oct 23.PMID: 17060454
Sullivan LS, Baylin EB, Font R, Daiger SP, Pepose JS, Clinch TE, Nakamura H, Zhao
XC, Yee RW. (2007) A novel mutation of the Keratin 12 gene responsible for a severe
phenotype of Meesmann's corneal dystrophy. Mol Vis. 2007 Jun 21;13:975-80.PMID:
17653038
Madhira SL, Vemuganti G, Bhaduri A, Gaddipati S, Sangwan VS, Ghanekar Y. (2008)
Culture and characterization of oral mucosal epithelial cells on human amniotic
membrane for ocular surface reconstruction. Mol Vis. 2008 Jan 30;14:189-96.PMID:
18334934
Dorà N, Ou J, Kucerova R, Parisi I, West JD, Collinson JM. (2008) PAX6 dosage effects
on corneal development, growth, and wound healing. Dev Dyn. 2008
16
Date of Preparation: March1st, 2015
Moll R, Divo M, Langbein L. (2008) The human keratins: biology and pathology.
Histochem Cell Biol. 2008 Jun;129(6):705-33. Epub 2008 May 7. Review.PMID:
18461349
Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA,
Govindarajan V. (2010) Activated Ras alters lens and corneal development through
induction of distinct downstream targets. BMC Dev Biol. 2010 Jan 27;10:13.PMID:
2010528
Clausen I, Duncker GI, Grünauer-Kloevekorn C. (2010) Identification of a novel
mutation in the cornea specific keratin 12 gene causing Meesmann's corneal dystrophy
in a German family. Mol Vis. 2010 May 29;16:954-60.PMID: 20577595
3. Chia-Yang Liu∗, A. Shiraishi, C. W.-C. Kao, R. L. Converse, J. L. Funderburgh, L.M.
Corpuz, G.W. Conrad, and W. W.-Y. Kao (1998) The Cloning of Mouse Keratocan cDNA
and Genomic DNA and the Characterization of Its Expression During Eye Development. J.
Biol. Chem. 273: 22584-22588. PMID: 9712886 ∗: Corresponding author
Significance: Isolation and characterization of Mouse Kera, the first corneal stromal-specific
gene.
Cited 2 times in the last five years
Mimura T, Amano S, Yokoo S, Uchida S, Usui T, Yamagami S. (2008) Isolation and
distribution of rabbit keratocyte precursors. Mol Vis. 2008 Jan 30;14:197-203.PMID:
18334932
Young RD, Swamynathan SK, Boote C, Mann M, Quantock AJ, Piatigorsky J,
Funderburgh JL, Meek KM. (2009) Stromal edema in klf4 conditional null mouse cornea
is associated with altered collagen fibril organization and reduced proteoglycans. Invest
Ophthalmol Vis Sci. 2009 Sep;50(9):4155-61. Epub 2009 Apr 22.PMID: 19387067
4. Chia-Yang Liu∗, H. Arar, C. Kao , and W. W.-Y. Kao (2000) Identification of A 3.2 KB
Cornea-Specific Murine Keratocan Promoter in the Adult Transgenic Mice. Gene 250: 8596. PMID: 10854782 ∗: Corresponding Author
Significance: Demonstration of Keratocan promoter activity is periocular mesenchyma
specific in vivo.
Cited 2 times in the last five years
Holmberg J, Ingner G, Johansson C, Leander P, Hjalt TA. (2008) PITX2 gain-of-function
induced defects in mouse forelimb development. BMC Dev Biol. 2008 Feb
29;8:25.PMID: 18312615
Wang IJ, Yu CJ, Hu FR. (2009) Alteration of ocular surface mucins in MUC5AC-DTA
transgenic mice. Mol Vis. 2009;15:108-19. Epub 2009 Jan 16.PMID: 19158956
5. Chia-Yang Liu∗, D. E. Birk, J. R. Hassell, B. Kane, and W. W.-Y. Kao (2003) Keratocandeficient mice display alterations in corneal structure. J. Biol. Chem. 278:21672-7. PMID:
12665512.∗: Corresponding Author
Significance: Establishment of Keratocan knockout mouse model for keratocyte
differentiation and pathogenesis of corneal plana
17
Date of Preparation: March1st, 2015
Cited 10 times in the last five years
Cooper LJ, Bentley AJ, Nieduszynski IA, Talabani S, Thomson A, Utani A, Shinkai H,
Fullwood NJ, Brown GM. (2006) The role of dermatopontin in the stromal organization
of the cornea. Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3303-10.PMID: 16877395
Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by
GlcNAc 6-O-sulfotransferase. (2006) Hayashida Y, Akama TO, Beecher N, Lewis P,
Young RD, Meek KM, Kerr B, Hughes CE, Caterson B, Tanigami A, Nakayama J,
Fukada MN, Tano Y, Nishida K, Quantock AJ. Proc Natl Acad Sci U S A. 2006 Sep
5;103(36):13333-8. Epub 2006 Aug 25.PMID: 16938851
Musselmann K, Kane BP, Alexandrou B, Hassell JR. (2008) IGF-II is present in bovine
corneal stroma and activates keratocytes to proliferate in vitro. Exp Eye Res. 2008
Mar;86(3):506-11. Epub 2007 Dec 23.PMID: 18237730
Melrose J, Fuller ES, Roughley PJ, Smith MM, Kerr B, Hughes CE, Caterson B, Little
CB. (2008) Fragmentation of decorin, biglycan, lumican and keratocan is elevated in
degenerate human meniscus, knee and hip articular cartilages compared with agematched macroscopically normal and control tissues. Arthritis Res Ther.
2008;10(4):R79. Epub 2008 Jul 14.PMID: 18620607
Zhang G, Chen S, Goldoni S, Calder BW, Simpson HC, Owens RT, McQuillan DJ,
Young MF, Iozzo RV, Birk DE. (2009) Genetic evidence for the coordinated regulation
of collagen fibrillogenesis in the cornea by decorin and biglycan. J Biol Chem. 2009 Mar
27;284(13):8888-97. Epub 2009 Jan 9.PMID: 19136671
Boote C, Hayes S, Young RD, Kamma-Lorger CS, Hocking PM, Elsheikh A, Inglehearn
CF, Ali M, Meek KM. (2009) Ultrastructural changes in the retinopathy, globe enlarged
(rge) chick cornea. J Struct Biol. 2009 May;166(2):195-204. Epub 2009 Mar 1.PMID:
19258040
Young RD, Swamynathan SK, Boote C, Mann M, Quantock AJ, Piatigorsky J,
Funderburgh JL, Meek KM. (2009) Stromal edema in klf4 conditional null mouse cornea
is associated with altered collagen fibril organization and reduced proteoglycans. Invest
Ophthalmol Vis Sci. 2009 Sep;50(9):4155-61. Epub 2009 Apr 22.PMID: 19387067
Jaworski CJ, Aryankalayil-John M, Campos MM, Fariss RN, Rowsey J, Agarwalla N,
Reid TW, Dushku N, Cox CA, Carper D, Wistow G. (2009) Expression analysis of
human pterygium shows a predominance of conjunctival and limbal markers and genes
associated with cell migration. Mol Vis. 2009 Nov 20;15:2421-34.PMID: 19956562
Yanai-Balser GM, Duncan GA, Eudy JD, Wang D, Li X, Agarkova IV, Dunigan DD, Van
Etten JL. (2010) Microarray analysis of Paramecium bursaria chlorella virus 1
transcription. J Virol. 2010 Jan;84(1):532-42. Epub .PMID: 19828609
Dimasi DP, Burdon KP, Hewitt AW, Savarirayan R, Healey PR, Mitchell P, Mackey DA,
Craig JE. (2010) Candidate gene study to investigate the genetic determinants of
normal variation in central corneal thickness. Mol Vis. 2010 Mar 31;16:562-9.PMID:
20360993
18
Date of Preparation: March1st, 2015
6. Chia-Yang Liu, A. Fleskin, S. Li, Y. Zeng, and W.-H. Lee (1996). Inactivation of the
mouse Brca1 gene leads to failure in the morphogenesis of the egg cynlinder development.
Genes & Development 10: 1835-43. PMID: 8698242
Significance: Establishment of Brca1 knockout mice and demonstration of indispensability of
Brca1 in early development
Cited 10 times in the last five years
Tavtigian SV, Deffenbaugh AM, Yin L, Judkins T, Scholl T, Samollow PB, de Silva D,
Zharkikh A, Thomas A. (2006) Comprehensive statistical study of 452 BRCA1 missense
substitutions with classification of eight recurrent substitutions as neutral. J Med Genet.
2006 Apr;43(4):295-305. Epub 2005 Jul 13.PMID: 16014699
Kim SS, Cao L, Lim SC, Li C, Wang RH, Xu X, Bachelier R, Deng CX. (2006)
Hyperplasia and spontaneous tumor development in the gynecologic system in mice
lacking the BRCA1-Delta11 isoform. Mol Cell Biol. 2006 Sep;26(18):6983-92.PMID:
16943438
Brooks WS, Banerjee S, Crawford DF. (2007) G2E3 is a nucleo-cytoplasmic shuttling
protein with DNA damage responsive localization. Exp Cell Res. 2007 Feb
15;313(4):665-76. Epub 2006 Dec 14.PMID: 17239372
Hoshino A, Yee CJ, Campbell M, Woltjer RL, Townsend RL, van der Meer R, Shyr Y,
Holt JT, Moses HL, Jensen RA. (2007) Effects of BRCA1 transgene expression on
murine mammary gland development and mutagen-induced mammary neoplasia. Int J
Biol Sci. 2007 Apr 25;3(5):281-91.PMID: 17505536
Hakem R. (2008) DNA-damage repair; the good, the bad, and the ugly. EMBO J. 2008
Feb 20;27(4):589-605. Review.PMID: 18285820
Greenberg RA. (2008) Recognition of DNA double strand breaks by the BRCA1 tumor
suppressor network. Chromosoma. 2008 Aug;117(4):305-17. Epub 2008 Mar 28.
Review.PMID: 18369654
Brooks WS, Helton ES, Banerjee S, Venable M, Johnson L, Schoeb TR, Kesterson RA,
Crawford DF. (2008) G2E3 is a dual function ubiquitin ligase required for early
embryonic development. J Biol Chem. 2008 Aug 8;283(32):22304-15. Epub 2008 May
28.PMID: 18511420
Ghosh AK, Kanda T, Steele R, Ray RB. (2008) Knockdown of MBP-1 in human foreskin
fibroblasts induces p53-p21 dependent senescence. PLoS One. 2008;3(10):e3384.
Epub 2008 Oct 13.PMID: 18852884
Goldgar DE, Easton DF, Byrnes GB, Spurdle AB, Iversen ES, Greenblatt MS; IARC
Unclassified Genetic Variants Working Group. (2008) Genetic evidence and integration
of various data sources for classifying uncertain variants into a single model. Hum Mutat.
2008 Nov;29(11):1265-72.PMID: 18951437
Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan AC, Pack M. (2008)
Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication
stress. PLoS Genet. 2008 Oct;4(10):e1000240. Epub 2008 Oct 31.PMID: 18974873
19
Date of Preparation: March1st, 2015
7. Lung-Kun Yeh, Wei-Li Chen, Wei Li, Edgar M. Espana, Jie Ouyang, Tetsuya Kawakita,
Winston W.-Y. Kao, Scheffer C.G. Tseng, and Chia-Yang Liu∗ (2005). Soluble lumican
glycoprotein purified from human amniotic membrane promotes corneal epithelial wound
healing. Invest Ophthalmol Vis Sci. 46:479-86. PMID: 15671272. ∗: Corresponding author
Significance: exogenous lumican can promote corneal epithelial wound healing.
8. Jie Ouyang, Ying-Cheng Shen, Lung-Kun Yeh, Wei Li, Brad M. Coyle, Chia-Yang Liu∗,
and M. Elizabeth Fini∗ (2006) Pax6 over-expression suppresses cell proliferation and
retards the cell cycle in corneal epithelial cells. Invest Ophthalmol Vis Sci. 47(6):2397-2407.
PMID: 16723449. ∗: Co-senior author
Significance: implication of Pax-6 transcription factor function as cell cycle regulator for
corneal epithelial cells.
Cited 5 times in the last five years
Leiper LJ, Walczysko P, Kucerova R, Ou J, Shanley LJ, Lawson D, Forrester JV,
McCaig CD, Zhao M, Collinson JM. (2006) The roles of calcium signaling and ERK1/2
phosphorylation in a Pax6+/- mouse model of epithelial wound-healing delay. BMC Biol.
2006 Aug 16;4:27.PMID: 16914058
Lesaffre B, Joliot A, Prochiantz A, Volovitch M. (2007) Direct non-cell autonomous Pax6
activity regulates eye development in the zebrafish. Neural Dev. 2007 Jan 17;2:2.PMID:
17229313
Dorà N, Ou J, Kucerova R, Parisi I, West JD, Collinson JM (2008) PAX6 dosage effects
on corneal development, growth, and wound healing. Dev Dyn. 2008 May;237(5):1295306.PMID: 18386822
Akinci MA, Turner H, Taveras M, Barash A, Wang Z, Reinach P, Wolosin JM. (2009)
Molecular profiling of conjunctival epithelial side-population stem cells: atypical cell
surface markers and sources of a slow-cycling phenotype. Invest Ophthalmol Vis Sci.
2009 Sep;50(9):4162-72. Epub 2009 Mar 25.PMID: 19324848
Chanas SA, Collinson JM, Ramaesh T, Dorà N, Kleinjan DA, Hill RE, West JD. (2009)
Effects of elevated Pax6 expression and genetic background on mouse eye
development. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4045-59. Epub 2009 Apr
22.PMID: 19387074
9. Taiichiro Chikama, Chia-Yang Liu∗, Johanna T.A. Meij, Yasuhito Hayashi, I-Jong Wang,
Liu Yang, Teruo Nishida, and Winston W.Y. Kao∗ (2008) Excess FGF-7 in corneal
epithelium causes corneal intraepithelial neoplasia in young mice and epithelium
hyperplasia in adult mice. Am J Pathol 172: 638-649. PMID: 18276784. ∗: Corresponding
author
Significance: Establishment of a mouse model for human ocular surface neoplasia. Linking
FGF-7 signaling to β-catenin signaling activation to alter corneal homeostasis.
10. Zhang Y, Call MK, Yeh LK, Liu H, Kochel T, Wang IJ, Chu PH, Taketo MM, Jester JV,
Kao WW, Chia-Yang Liu∗. (2010) Aberrant expression of a β-catenin gain-of-function mutant
induces hyperplastic transformation in the mouse cornea. J Cell Sci 123: 1285-1294. PMID:
20332116. ∗: Corresponding author
20
Date of Preparation: March1st, 2015
Significance: Wnt/β-catenin signaling needs to be repressed to maintain corneal
homeostasis and inhibitors against Wnt/b-catenin may be beneficial to treat human ocular
surface neoplasia.
D. Abstracts
1992
C.-Y. Liu, Bjorn R. Olsen, and Winston W.-Y. Kao (1992) Developmental Patterns of two
α1(IX) collagen mRNA isoforms in mouse. ARVO annual meeting at Sarasota, Florida
(May3-8) (Poster Presentation);
1993
C.-Y. Liu, Guang Zhu, Richard Converse, Candace W.-C. Kao, Hiroshi Nakamura, Scheffer
C.-G. Tseng, Mei-Mei Mui, Jerome Seyer, Monica J Justice, Mary E. Stech, Gwenn M.
Hansen, and Winston W.-Y.Kao (1993) Molecular Cloning and Characterization of the
Cornea-Specific Murine K12 Keratin gene. ARVO annual meeting at Sarasota, Florida
(May2-7) (Poster Presentation)
1996
C.-Y. Liu, Andrea Fleskin-Nikitin, Shang Li, Yingying Zeng, and Wen-Hwa Lee (1996)
Inactivation of the Mouse Brca1 Gene Leads To Failure in the Morphogenesis of the Egg
Cynlinder; Cold Spring Harbor Symposium in Tumor Suppressor Genes and Cancer
Genetics at Cold Spring Harbor, Long Island, New York (July)(Oral Presentation)
1998
C.-Y. Liu, Atsushi Shiraishi, Candace W.-C. Kao, Richard L. Converse, James L.
Funderburgh, L.M. Corpuz, G.W. Conrad, and Winston W.-Y. Kao (1998) Molecular Cloning
and Characterization of the Cornea-Specific Murine Keratan Sulphate Proteoglycan Gene,
Keratocan. ARVO annual meeting at Ft. Lauderdale, Florida (May3-8) (Oral Presentation)
C.-Y. Liu and Winston W.-Y. Kao (1998) Molecular Cloning and Characterization of the
Cornea-Specific Murine Keratan Sulphate Proteoglycan Gene, Keratocan Gordon Research
Conference/Proteoglycans at Proctor AcademyAndover, NH (July 5-10, 1998) (Short Talk)
1999
C.-Y. Liu and Winston W.-Y. Kao (1999) The Murine Lumican Gene Expression is
Differentially Regulated by Cell-Density, TGFβ2, and Ascorbic Acid; ARVO annual meeting
at Ft. Lauderdale, Florida (May2-7) (Poster Presentation)
C.-Y. Liu, Shizuya Saika, Satoko Saika, Candace Kao, Azar Muhamad, Philip Sanford,
Thomas Doetschman, and Winston W.-Y. Kao (1999) TGFβ2 Involves Corneal
Morphogenesis during Mouse Embryonic Development; Keystone Symposium on Ocular
Molecular and Cellular Biology at Keystone, Colorado (Oral Presentation)
C.-Y. Liu, Hisham Arar, Candace Kao, and Winston W.-Y. Kao (1999) Identification of A 3.2
KB Cornea-Specific Murine Keratocan Promoter in the Adult Transgenic Mice; The 39th
ASCB annual meeting at Washington, DC (Poster Presentation)
2000
21
Date of Preparation: March1st, 2015
C.-Y. Liu, Hisham Arar, Candace Kao, and Winston W.-Y. Kao (2000) Identification of A 3.2
KB Cornea-Specific Murine Keratocan Promoter in the Adult Transgenic Mice ARVO annual
meeting at Ft. Lauderdale, Florida (April30-May5) (Oral Presentation)
C.-Y. Liu, I-Jong Wang, Candace Kao, and Winston W.-Y. Kao (2000) Transgenic Mouse
Model for Ocular Surface Disorders; 5th International Ocular Surface Society annual
Meeting at Ft. Lauderdale, Florida (Oral Presentation)
C.-Y. Liu, Helene Paradis, Robert Gendron, Pascal Chapon, Scheffer Tseng, Candace Kao,
and Winston W.-Y. Kao (2000) AngX/CDT6, a novel fibrinogen/angiopoietin-like factor that
enhances angiogenesis in vivo; The 40th American Society for Cell Biology annual meeting
at San Francisco (Dec.9-13) (Poster Presentation)
C.-Y. Liu, J.R. Hassel, B. Kane, T.C. Doetschman, W.W. Y. Kao (2000) Generation of the
Keratocan Gene-Targeted Mutagenesis in the Mouse; ARVO annual meeting at Ft.
Lauderdale, Florida (April30-May5) (Oral Presentation)
2002
C.-Y. Liu, JR Hassel, B Kane, TC Doetschman, and WW Y Kao (2002) Generation of the
Keratocan Gene-Targeted Mutagenesis in the Mouse. Invest. Ophthalmol. Vis. Sci. 2002 43:
E-Abstract 2936. ARVO annual meeting at Ft. Lauderdale, Florida (April28-May3) (Oral
Presentation).
M Hayashi, C.-Y. Liu, Y Hayashi, J Tichelaar, JA Whitsett, and WW Kao (2002) Induction of
Corneal Epithelial Hypertrophy by FGF-7 in a Binary Inducible Transgenic Mouse Model.
Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 1649. ARVO annual meeting at Ft.
Lauderdale, Florida (April28-May3) (Poster Presentation).
PA Brannan, E Carlson, IJ Wang, C.-Y. Liu, C Kao, and W Kao (2002) The Correlation of
Clinical Observations and Expression of Extracellular Matrix Proteins and -Smooth Muscle
Actin in Corneal Wound Healing. Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 1706.
ARVO annual meeting at Ft. Lauderdale, Florida (April28-May3) (Poster Presentation).
Y Hayashi, C.-Y. Liu, S Saika, M Hayashi, I-J Wang, JL Funderburgh, CW Kao, and WW
Kao (2002) Further Characterization of KeraprBgn/+ Transgenic Mice. Invest. Ophthalmol.
Vis. Sci. 2002 43: E-Abstract 3216. ARVO annual meeting at Ft. Lauderdale, Florida
(April28-May3) (Poster Presentation).
S Saika, T Miyamoto, Y Okada, N Hashizume, Y Ohnishi, A Ooshima, C.-Y. Liu, and WW Y
Kao (2002) TGFβ-SMAD Signaling and MAP Kinase Signaling in Healing Corneal
Epithelium in Mice. Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 1982. ARVO annual
meeting at Ft. Lauderdale, Florida (April28-May3) (Oral Presentation).
Y Xia, L Zhang, Y Hayashi, CW C Kao, C.-Y. Liu, D Birk, JV Jester, and WW Y Kao (2002)
Role of MEKK1 in Mouse Ocular Surface Morphogenesis. Invest. Ophthalmol. Vis. Sci. 2002
43: E-Abstract 2000. ARVO annual meeting at Ft. Lauderdale, Florida (April28-May3)
(Poster Presentation).
2003
D.Y. Weng, Y. Hayashi, C.-Y. Liu, and W.W. Kao (2003) Preparation of Kera-Cre
Transgenic Mice in Which a Floxed Gene is Removed in Keratocytes. Invest. Ophthalmol.
22
Date of Preparation: March1st, 2015
Vis. Sci. 2003 44: E-Abstract 2142. ARVO annual meeting at Ft. Lauderdale, Florida (May 49) (Poster Presentation).
I. Wang, W.W. Kao, and C.-Y. Liu (2003) The Change of Mucins in Conjunctival Goblet Cells
in MUC5AC-DTA Transgenic Mice. Invest. Ophthalmol. Vis. Sci. 2003 44: E-Abstract 3775.
ARVO annual meeting at Ft. Lauderdale, Florida (May 4-9) (Poster Presentation).
Y. Hayashi, C.-Y. Liu, M. Hayashi, T. Chikama, T. Doetschman, and W.W. Kao (2003)
Preparation of K12-Cre Knock-In Mice by Gene Targeting Techniques. Invest. Ophthalmol.
Vis. Sci. 2003 44: E-Abstract 909. ARVO annual meeting at Ft. Lauderdale, Florida (May 49) (Poster Presentation).
C.-Y Liu, M. Azhar, T.C. Doetschman, B.J. Aronow, S. Kong, and W.W. Kao (2003) Gene
Expression Profiling of the Mouse Eye Lacking Tgfb2. Invest. Ophthalmol. Vis. Sci. 2003 44:
E-Abstract 410. ARVO annual meeting at Ft. Lauderdale, Florida (May 4-9) (Poster
Presentation).
K.M. Meek, A.J. Quantock, S. Akhtar, C.-Y. Liu, and W. Kao (2003) Collagen Fibril
Disorganisation in the Corneas of Keratocan-deficient Mice as Revealed by Synchrotron Xray Diffraction. Invest. Ophthalmol. Vis. Sci. 2003 44: E-Abstract 883. ARVO annual meeting
at Ft. Lauderdale, Florida (May 4-9) (Poster Presentation).
S. Saika, Y. Ohnishi, M. Sato, A. Ooshima, K.C. Flanders, M. Anzono, J. Yoo, C. Liu, W.W.
Kao, and A.B. Roberts (2003) TGF Beta-Smad3 Signaling Is Required for EpithelialMesenchymal Transition of Lens Epithelium. Invest. Ophthalmol. Vis. Sci. 2003 44: EAbstract 4505. ARVO annual meeting at Ft. Lauderdale, Florida (May 4-9) (Oral
Presentation).
T. Tanaka, S. Saika, J.W. McAvoy, C.-Y. Liu, M. Azhar, Y. Ohnishi, A. Ooshima, T.
Doetschman, and W.W. Kao (2003) Loss of Fgf2 Retards Proliferation without Impairing
Epithelial-mesenchymal Transition of Lens Epithelial Cells upon Injury. Invest. Ophthalmol.
Vis. Sci. 2003 44: E-Abstract 4508. ARVO annual meeting at Ft. Lauderdale, Florida (May 49) (Poster Presentation).
2004
T.-I. Chikama, C.-Y. Liu, and W.W. Kao (2004) Lumican Has A Critical Role in Modulating
Inflammatory Responses during Corneal Wound Healing. Invest. Ophthalmol. Vis. Sci. 2004
45: E-Abstract 1166. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster
Presentation).
M.A. Di Pascuale, E.M. Espana, H. He, T. Kawakita, C.-Y. Liu, and S.C. G. Tseng (2004)
Characterization of Corneal Pannus Removed from Patients with Total Limbal Stem Cell
Deficiency. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 1436. ARVO annual meeting
at Ft. Lauderdale, Florida (April25-29) (Poster Presentation).
L.K. Yeh, T. Kawakita, E.M. Espana, H. He, C.-Y. Liu, and S.C. G. Tseng (2004). Air
Exposure Promotes Intrastromal Invasion of Rabbit limbal Epithelial Cells at the Limbal
Location in Vivo. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 1438. ARVO annual
meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation).
23
Date of Preparation: March1st, 2015
T. Kawakita, E.M. Espana, H. He, M. Di Pascuale, C.-Y. Liu, and S.C. G. Tseng (2004). In
Vitro Growth and Differentiationof MouseCorneal Epitheliumon Plastic Dependson
Extracellular Calcium Concentration. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 1450.
ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation).
D.Y. Weng, T.-I. Chikama, Y. Hayashi, C.-Y. Liu, and W.W. Kao (2004). Structure And
Function Relationship of Lumican: Role of N–terminal Disulfide Bond. Invest. Ophthalmol.
Vis. Sci. 2004 45: E-Abstract 4550. ARVO annual meeting at Ft. Lauderdale, Florida
(April25-29) (Poster Presentation).
J. Ouyang, E.C. Carlson, V.L. Perez, T. Chikama, W.W. Kao, H. Yi, L.-K. Yeh, M.E. Fini, and
C.-Y. Liu (2004) In Vivo Characterization of the Murine Keratocan (mKera) Promoter. Invest.
Ophthalmol. Vis. Sci. 2004 45: E-Abstract 4714. ARVO annual meeting at Ft. Lauderdale,
Florida (April25-29) (Poster Presentation).
H. Yi, J. Ouyang, L.-K. Yeh, C.W. Kao, W.W. Kao, and C.-Y. Liu (2004) Characterzation of a
novel mCDT22 transcript in the murine cornea and retina. Invest. Ophthalmol. Vis. Sci. 2004
45: E-Abstract 4715. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster
Presentation).
Y. Hayashi, C.-Y. Liu, C.C. Kao, T. Doetschman, M. Hayashi, and W.W. Kao (2004)
Selected Expression of One of the Two Krt12 Alleles during Corneal Type Epithelial
Differentiation. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 2223. ARVO annual
meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation).
W.-L. Chen, C.-Y. Liu, Y. Hayashi, T-I. Chikama, and W.W. Kao (2004) Further
Characterization of Keratocan Promoter. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract
3778. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation).
C.W. C. Kao, E.C. Carlson, C.-Y. Liu, T.-I. Chikama, D.E. Birk, J.L. Funderburgh, J.J. Jester,
and W.W. Kao (2004) Lumican Modulates Keratocan Gene Expression. Invest. Ophthalmol.
Vis. Sci. 2004 45: E-Abstract 3779. ARVO annual meeting at Ft. Lauderdale, Florida
(April25-29) (Poster Presentation).
H. He, E.M. Espana, T. Kawakita, D. Tseng, C.-Y. Liu, and S.C. G. Tseng (2004)
Suppression of TGF-β Signaling and Myofibroblast Differentiation in Human Keratocytes
Maintained by Amniotic Membrane Stromal Matrix. Invest. Ophthalmol. Vis. Sci. 2004 45: EAbstract 3782. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster
Presentation).
E.M. Espana, T. Kawakita, H. He, M.A. Di Pascuale, V. Raju, R. Smiddy, C.-Y. Liu, and S.C.
G. Tseng (2004) Human And Mouse Keratocyte Morphology And Expression Of Keratocan
And Cd 34 Are Maintained Duing Expansion By Serum Containing Media On Amniotic
Membrane Stroma. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 3837. ARVO annual
meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation).
C.-Y. Liu, Y. Hayashi, J.J. Jester, M. Hayashi, I.-J. Wang, J.L. Funderburgh, S. Saika, P.J.
Roughley, C.W. Kao, and W.W. Kao (2004) Excess Biglycan Interferes with TGF-α
Signaling Required for Eyelid Morphogenesis. Invest. Ophthalmol. Vis. Sci. 2004 45: EAbstract 712. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster
Presentation).
24
Date of Preparation: March1st, 2015
C.-Y. Liu, Edgar M. Espana, Tetsuya Kawakita, Hua He, and Scheffer Tseng (2004) Corneal
Keratocytes Cultured on human Amniotic Membrane (hAM) Stroma Preserve Morphology
and Express Keratocyte Markers. XVI International Congress of Eye Research at Sydney,
Australia (August29-September 3) (Oral Presentation)
2005
E.C. Carlson, X. Yang, C.-Y. Liu, G. Amescua, and V.L. Perez (2005) Regulation of
Neutrophil Migration in the Corneal Stroma by Chemokines and Proteoglycans in
Endotoxin–Induced Keratitis. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 1170. ARVO
annual meeting at Ft. Lauderdale, Florida (May1-5) (Oral Presentation).
W.Y. Kao, E.C. Carlson, C.-Y. Liu, Y. Hayashi, T.-I. Chikama, M.M. Mann, D.E. Birk, J.V.
Jester, and J.L. Funderburgh (2005) Lumican Modulates Keratocan Gene Expression.
Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 3559. ARVO annual meeting at Ft.
Lauderdale, Florida (May1-5) (Poster Presentation).
T.-I. Chikama, Y. Hayashi, C.Y. Liu, N. Terai, K. Terai, C.W. C. Kao, L. Wang, T. Nishida, T.
Doestchman, and W.W. Y. Kao (2005) Induction of Corneal Epithelium–specific LacZ
Expression in Bitransgenic Krt12-rtTA/tetO-lacZ Mice. Invest. Ophthalmol. Vis. Sci. 2005 46:
E-Abstract 3621. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster
Presentation).
A Assadoullina, A. Abri, P. Catanuto, C.-Y. Liu, H. Yamamoto, A.C. Acosta, J.M. Parel, and
S. Binder (2005) Comparison of Indocyanine Green and Trypan Blue Related Toxicity in
RPE 19 Cell Culture With Light Exposure. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract
5311. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation).
D.-Y. Weng, C.-Y. Liu, and W.W. Y. Kao (2005) Keratocan-Cre Transgenic Mouse: A New
Model for Neural–Crest Cell Lineage Analysis During Embryonic Development. Invest.
Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2594. ARVO annual meeting at Ft. Lauderdale,
Florida (May1-5) (Poster Presentation).
J. Ouyang, S.-Y. Cheng, L.-K. Yeh, C.-Y. Liu, and M.E. Fini (2005) Over–Expression of
Pax6 Retards Cell Cycle Progression and Reduces Cell Migration Rate in Corneal Epithelial
Cells. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2595. ARVO annual meeting at Ft.
Lauderdale, Florida (May1-5) (Poster Presentation).
H. Yi, E. Carlson, J. Ouyang, V. Perez, Y.-F. Lee, W.-Y. Kao, and C.-Y. Liu (2005)
In vivo Identification of the Cis–Regulatory Elements of the Murine Keratocan (mKera)
Gene. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2608. ARVO annual meeting at Ft.
Lauderdale, Florida (May1-5) (Poster Presentation).
L.-K. Yeh, J. Ouyang, C.-Y. Liu, W.-Y. Kao, and I.-J. Wang (2005) Molecular Analysis of the
Zebra Fish Lumican (zLum) and Keratocan (zKera) Genes. Invest. Ophthalmol. Vis. Sci.
2005 46: E-Abstract 2610. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5)
(Poster Presentation).
C.-L. Kuo, S. Tseng, H. Yi, J. Ouyang, L.-K. Yeh, W.-Y. Kao, and C.-Y. Liu (2005)
Characterization of SARG/CDT22 in Ocular Surface. Invest. Ophthalmol. Vis. Sci. 2005 46:
25
Date of Preparation: March1st, 2015
E-Abstract 5151. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster
Presentation).
T. Tanaka, S. Saika, Y. Ohnishi, C.-Y. Liu, M. Azhar, T. Doetschman, and W.W. Kao (2005)
Loss of FGF2 Retards Proliferation of Epithelial Cells in an Uninjured or a Penetrating
Injured Cornea in Mice. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2118. ARVO
annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation).
C. Kao, T.-I. Chikama, C.-Y. Liu, S.A. K. Harvey, M.L. Funderburgh, J.L. Funderburgh, and
W.W. Kao (2005) Lumican Serves as a Substratum for PMN Formation and Migration during
Myelopoiesis and Corneal Wound Healing Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract
2130. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation).
C.-Y. Liu, T.-I. Chikama, E. Carlson, V.L. Perez, and W.W. Kao (2005) Role of Keratocan in
Corneal Epithelium During Wound Healing. Invest. Ophthalmol. Vis. Sci. 2005 46: EAbstract 2131. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster
Presentation).
Y. Hayashi, C.-Y. Liu, D.Y. Weng, and W.W. Kao (2005) Role of cJun in Eyelid
Morphogenesis during Mouse Embryonic Development. Invest. Ophthalmol. Vis. Sci. 2005
46: E-Abstract 2177. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster
Presentation).
C.-Y. Liu, Edgar M. Espana, Tetsuya Kawakita, Wei Li, Lung-Kun Yeh, Jean-Marie Parel,
and Scheffer C. G. Tseng (2005) The Heterogeneous Murine Corneal Stromal Cell
Populations In Vitro. The International Society for Ocular Cell Biology (ISOCB) meeting at
Sarasota, Florida (October) (Poster presentation)
2006
D.-Y. Weng, Y. Hayashi, C.-Y. Liu, S. Schwemberger, G. Babcock, A. Kuan, and W.W. Y.
Kao (2006) Cryptic Cre Activity During Gametogenesis in Cre–loxP Transgenic Mouse
Lines. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 1588. ARVO annual meeting at Ft.
Lauderdale, Florida (April30-May4) (Poster Presentation).
Y. Zhang, R.L. Converse, C.-Y. Liu, L.-K. Yeh, H. Liu, and W.W. Y. Kao (2006) Identification
of Talin and 14-3-3 as SARG Interacting Proteins in Corneal Epithelium by Two–Hybrid
System. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 1599. ARVO annual meeting at
Ft. Lauderdale, Florida (April30-May4) (Poster Presentation).
L.-K. Yeh, C.-Y. Liu, W.-Y. Kao, C.-L. Chien, and I.-J. Wang (2006) Molecular
Characterizations of the Zebrafish Lumican (zLum) and Keratocan (zKera) Genes. Invest.
Ophthalmol. Vis. Sci. 2006 47: E-Abstract 3006. ARVO annual meeting at Ft. Lauderdale,
Florida (April30-May4) (Poster Presentation).
T.-I. Chikama, Y. Hayashi, C.-Y. Liu, W.-C. Kao, L. Wang, T. Nishida, and W.W. Kao (2006)
Effects of Excess FGF7 on Development and Differentiation of Corneal Epithelial Cells.
Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 3010. ARVO annual meeting at Ft.
Lauderdale, Florida (April30-May4) (Poster Presentation).
26
Date of Preparation: March1st, 2015
J. Ouyang, C.-Y. Liu, and M.E. Fini (2006) Role of Transcription Factor Pax6 in Corneal
Epithelial Cell Migration. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 5021. ARVO
annual meeting at Ft. Lauderdale, Florida (April30-May4) (Poster Presentation).
E. C. Carlson, M. Lin, C.-Y. Liu, W.W. Y. Kao, and E. Pearlman (2006) Alterations in
Extracelluar Matrix Gene Expression Due to Corneal Inflammation. Invest. Ophthalmol. Vis.
Sci. 2006 47: E-Abstract 4356. ARVO annual meeting at Ft. Lauderdale, Florida (April30May4) (Oral Presentation).
C.-Y. Liu, D. Weng, Y. Hayashi, and W.W. Kao (2006) Induction of LacZ Expression in
Kera3.2-int-rtTA /tet-O-Cre /Rosa26-LacZ Transgenic Mice. Invest. Ophthalmol. Vis. Sci.
2006 47: E-Abstract 2327. ARVO annual meeting at Ft. Lauderdale, Florida (April30-May4)
(Oral Presentation).
C.-Y. Liu, Johan Holmberg, and Tord A. Hjalt (2006) PITX2 Gain-of-Function in Rieger
Syndrome Eye Model; XVII International Congress of Eye Research at Buenos Aires,
Argentina (October 29-November3) (Oral Presentation)
2007
Y. Zhang, R. Converse, H. Liu, J. Jester, W.-Y. Kao, and C.-Y. Liu (2007) Over-Expression
of SARG Triggers Apoptosis in Human Corneal Epithelial Cells. Invest. Ophthalmol. Vis. Sci.
2007 48: E-Abstract 547. ARVO annual meeting at Ft. Lauderdale, Florida (May6-10)
(Poster Presentation)
Y. Hayashi, M. Hayashi, Y. Shirakata, W.-L. Chen, C.-Y. Liu, K. Hashimoto, Y. Ohashi, and
W. W. Kao (2007) Over-Expression of FGF7 Causes Sex Dependent Change in Eyelid
Morphogenesis. Invest. Ophthalmol. Vis. Sci. 2007 48: E-Abstract 5876. ARVO annual
meeting at Ft. Lauderdale, Florida (May6-10) (Poster Presentation)
H. Liu, C.-Y. Liu, E. Carlson, and W. Kao (2007) Bone Marrow Cells Can Differentiate and
Assume Keratocyte Characteristics of Keratocan Expression in Mouse Corneas. Invest.
Ophthalmol. Vis. Sci. 2007 48: E-Abstract 4435. ARVO annual meeting at Ft. Lauderdale,
Florida (May6-10) (Oral Presentation)
J. T. Meij, E. C. Carlson, L. Wang, C.-Y. Liu, J. V. Jester, D. E. Birk, and W. W. Kao (2007)
Cornea-Targeted Lumican Transgene Enhances Corneal Transparency and. Keratocan
Expression in Mice Lacking the Lumican Gene. Invest. Ophthalmol. Vis. Sci. 2007 48: EAbstract 1485. ARVO annual meeting at Ft. Lauderdale, Florida (May6-10) (Poster
Presentation)
E. Carlson, M. Lin, C.-Y. Liu, V. Perez, W. Kao, and E. Pearlman (2007) Lumican and
Keratocan Regulate Neutrophil Infiltration to the Corneal Stroma in Microbial Keratitis.
Invest. Ophthalmol. Vis. Sci. 2007 48: E-Abstract 3647. ARVO annual meeting at Ft.
Lauderdale, Florida (May6-10) (Oral Presentation)
C.-Y. Liu, T. Chikama, Y. Hayashi, C. W. C. Kao, L. Wang, J. Meij, T. Nishida, and W. W.-.
Y. Kao (2007) Age-Dependent Corneal Anomalies by Excess FGF7 in Bitransgenic Krt12rtTA/tetO-FGF7 Mice Upon Doxycyclin Induction. Invest. Ophthalmol. Vis. Sci. 2007 48: EAbstract 4929. ARVO annual meeting at Ft. Lauderdale, Florida (May6-10) (Oral
Presentation)
27
Date of Preparation: March1st, 2015
2008
W. W. Kao, J. V. Jester, C.-Y. Liu, Y. Hayashi, D. Weng, and E. Carlson (2008) Neural Crest
Derived Periocular Mesenchymal Cell Lineages in Ocular Surface Tissues. Invest.
Ophthalmol. Vis. Sci. 2008 48: E-Abstract 4926. ARVO annual meeting at Ft. Lauderdale,
Florida (April 27-May 1) (Poster Presentation)
C.-Y. Liu, H. Liu, J. Zhang, Y. Hayashi, and W. W. Y. Kao (2008) Role of KeratocanExpressing Cells in Corneal Homeostasis. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract
4826. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster
Presentation)
H. Liu, J. V. Jester, M. Sieber, J. Chang, C.-Y. Liu, and W. W. Kao (2008) Human
Mesenchymal Stem Cells Differentiate Into Keratocytes in the Mouse Cornea. Invest.
Ophthalmol. Vis. Sci. 2008 49: E-Abstract 4519. ARVO annual meeting at Ft. Lauderdale,
Florida (April 27-May 1) (Oral Presentation)
R. Paugh, C. Nien Shy, C.-Y. Liu, H. Liu, W. W. Kao, and J. V. Jester (2008) Morphogenesis
of the Mouse Meibomian Gland. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 89. ARVO
annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster Presentation)
J. T. A. Meij, C. Y. Liu, Y. Zhang, C. W. C. Kao, and W. W. Y. Kao (2008) Time-Course of
Corneal Stromal Neovascularization and Ocular Surface Squamous Neoplasia Development
in Bi-Transgenic Krt12-rtTA/TetO-FGF7 Mice, Depends on Age of Induction. Invest.
Ophthalmol. Vis. Sci. 2008 49: E-Abstract 2368. ARVO annual meeting at Ft. Lauderdale,
Florida (April 27-May 1) (Poster Presentation)
S. Li, J. T. A. Meij, J. Hao, Y. Zhang, T.-H. Young, W. W. Y. Kao, and C. Y. Liu (2008)
Electric Field Enhanced Delivery of Macromolecules for Gene Transfer in the Corneal
Epithelium. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 3194. ARVO annual meeting
at Ft. Lauderdale, Florida (April 27-May 1) (Poster Presentation)
Y. Zhang, R. Converse, W.-Y. Kao, and C.-Y. Liu (2008) Pax6 Up-Regulates p21
Expression in Corneal Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract
4291. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster
Presentation)
M.-T. T. Nguyen, Y. Hayashi, C.-Y. Liu, H. Liu, and W. W. Y. Kao (2008) Investigation of
Limbal Stem Cell Regenerative Capacity. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract
6070. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster
Presentation)
C.-Y. Liu, Taiichiro Chikama, and Winston Kao (2008) Role of FGF-7 in Ocular Surface
Squamous Neoplasia; 11th International Ocular Surface Society annual Meeting at Ft.
Lauderdale, Florida (April26) (Oral Presentation)
C.-Y. Liu, Mindy K. Call, Yujin Zhang, Makoto M. Taketo, Winston W.-Y. Kao (2008) The role
of β-catenin signaling in ocular surface homeostasis and tumorigenesis. XVIII International
Congress of Eye Research at Beijing, China (September 24-29) (Oral Presentation);
2009
28
Date of Preparation: March1st, 2015
Y. Zhang, J. Jester, P. Reinach, W. Kao, and C.-Y. Liu (2009) Fgf7 Stimulates Proliferation
and Expression of Angiogenic Factors of Human Corneal Epithelial Cells. Invest.
Ophthalmol. Vis. Sci. 2009 50: E-Abstract 2590. ARVO annual meeting at Ft. Lauderdale,
Florida (May 3-7) (Poster Presentation)
C.-Y. Liu, M. Call, Y. Zhang, and W. W. Kao (2009) The Role of β-catenin Signaling in
Ocular Surface Homeostasis and Tumorigenesis. Invest. Ophthalmol. Vis. Sci. 2009 50: EAbstract 2594. ARVO annual meeting at Ft. Lauderdale, Florida (May 3-7) (Poster
Presentation)
H. Liu, J. Zhang, C.-Y. Liu, and W. W. Kao (2009) Corneal Epithelium Can Migrate to Cover
Conjunctival Defect. Invest. Ophthalmol. Vis. Sci. 2009 50: E-Abstract 6293. ARVO annual
meeting at Ft. Lauderdale, Florida (May 3-7) (Poster Presentation)
M. K. Call, C.-Y. Liu, W. W. Kao, and M. M. Taketo (2009) The Role of β-catenin in Corneal
Wound Healing. Invest. Ophthalmol. Vis. Sci. 2009 50: E-Abstract 6300. ARVO annual
meeting at Ft. Lauderdale, Florida (May 3-7) (Poster Presentation)
C.-Y. Liu, Mindy K. Call, Yujin Zhang, Makoto M. Taketo, Winston W.-Y. Kao (2009) The role
of β-catenin signaling in ocular surface homeostasis and tumorigenesis; 49th ASCB annual
meeting at San Diego, CA (December 5-9) (Poster Presentation)
2010
C.-Y. Liu, Yujin Zhang, and Winston Kao (2010) Aberrant activation of Notch1 interrupts
eyelid morphogenesis, leading to congenital blepharophimosis. Gordon Research
Conference/Biology & Pathobiology of the Cornea at Ventura, CA (March 7-12) (Poster
Presentation)
C.-Y. Liu, Yujin Zhang, and Winston Kao (2010) Constitutive activation of Notch signaling
pathway disrupts eyelid morphogenesis during mouse embryonic development; 13th
International Ocular Surface Society annual Meeting at Ft. Lauderdale, Florida (May1st)
(Oral Presentation)
C.-Y. Liu, Y. Zhang, and W. W. Y. Kao (2010) Constitutive Activation of Notch Pathway
Disrupts Eyelid Morphogenesis During and Following Mouse Development. Invest.
Ophthalmol. Vis. Sci. 51: E-Abstract 3491. ARVO annual meeting at Ft. Lauderdale, Florida
(May 2-6) (Oral Presentation)
Y. Zhang, W.-Y. Kao, and C.-Y. Liu (2010) Expression of β-Catenin Gain-Of-Function
Mutant Disrupts Fetal Eyelid Closure in the Mouse. Invest. Ophthalmol. Vis. Sci. 51: EAbstract 707. ARVO annual meeting at Ft. Lauderdale, Florida (May 2-6) (Poster
Presentation)
J. Zhang, H. Liu, Y. Zhang, M.-T. Nguyen, M. Call, C.-Y. Liu, and W. W. Kao (2010)
Characterization of a Tet-On Inducible, Pax6 Promoter Driven Transgenic Mouse Line.
Invest. Ophthalmol. Vis. Sci. 51: E-Abstract 350. ARVO annual meeting at Ft. Lauderdale,
Florida (May 2-6) (Poster Presentation)
M. K. Call, J. Zhang, Y. Zhang, S. Eleswarpu, C.-Y. Liu, and W. W. Kao (2010) Lineage
Tracing of Periocular Mesenchymal Cells of Neural Crest Origin in Ocular Surface Tissue
29
Date of Preparation: March1st, 2015
Morphogenesis During Development. Invest. Ophthalmol. Vis. Sci. 51: E-Abstract 351.
ARVO annual meeting at Ft. Lauderdale, Florida (May 2-6) (Poster Presentation)
M.-T. T. Nguyen, C.-Y. Liu, R. Ashery-Padan, and W. W. Y. Kao (2010) Investigation of
Pax6 Function in Mouse Cornea Using an Inducible Deletion Mouse Model,
K12rtTA/tetOCre/Pax6flox. Invest. Ophthalmol. Vis. Sci. 2010 51: E-Abstract 354. ARVO
annual meeting at Ft. Lauderdale, Florida (May 2-6) (Poster Presentation)
O. Yamanaka, Y. Zhang, C.-Y. Liu, S. Saika, and W. W. Kao (2010) Lumican Promotes
Wound Healing by Enhaning Cell Proliferation via ERK Pathway in Cultured Human Corneal
Epithelial Cell in vitro. Invest. Ophthalmol. Vis. Sci. 2010 51: E-Abstract 365. ARVO annual
meeting at Ft. Lauderdale, Florida (May 2-6) (Poster Presentation)
H. Liu, J. Zhang, C.-Y. Liu, and W. W. Kao (2010) Corneal Epithelial Progenitors Can
Maintain Corneal Surface Homeostasis for a Limited Period of Time Following Limbal
Deficiency. Invest. Ophthalmol. Vis. Sci. 2010 51: E-Abstract 6369. ARVO annual meeting
at Ft. Lauderdale, Florida (May 2-6, 2010) (Oral Presentation)
2011
Winston W. Kao, Jeffrey Miller, Hongshan Liu, William D. Hardie, Chia-Yang Liu. 309/D773
- Distinct Pathogenesis by Excess TGF-α: Anterior Segment Dysgenesis (ASD) and FGF-7:
Ocular Surface Squamous Neoplasia (OSSN). ARVO annual meeting at Ft. Lauderdale,
Florida (May 1-5) (Poster)
Chia-Yang Liu, Yujin Zhang, Winston W. Kao. 1108/D732 - Notch Activation Downregulates
Foxl2, Leading To Congenital Blepharophimosis. ARVO annual meeting at Ft. Lauderdale,
Florida (May 1-5) (poster)
Minh-Thanh T. Nguyen, Chia-yang Liu, Ruth Ashery-Padan, Winston W. Kao. 1925/D906 Investigation Of Pax6 Function In Mouse Ocular Surface Mesenchyme Using A Tissue
Specific Mouse Model, Wnt1cre+/Pax6flox/RosamTmG. ARVO annual meeting at Ft.
Lauderdale, Florida (May 1-5). (Poster)
Osamu Yamanaka, Yong Yuan, Yujin Zhang, Chia-Yang Liu, Shizuya Saika, Winston W.
Kao. 1946/D927 - Lumican Binds TGF-β type I receptor and Stimulates the Phosphorylation
of ERK and Smads in Cultured Corneal Epithelial Cells. ARVO annual meeting at Ft.
Lauderdale, Florida (May 1-5) (poster)
Yujin Zhang, Winston W-Y Kao, Chia-Yang Liu, 2093 - Conditional Knock-out β-catenin
Disrupts Mouse Fetal Eyelid Morphogenesis. ARVO annual meeting at Ft. Lauderdale,
Florida (May 1-5) (Platform presentation)
Yong Yuan, Daniel M. Miller, Penny Groves, Winston W. Kao, James J. Augsburger, ChiaYang Liu. 2317/A589 - MicroRNA Profiling of Peripheral Blood Monocytes from Patients
with Dry Age Related Macular Degeneration. ARVO annual meeting at Ft. Lauderdale,
Florida (May 1-5) (poster)
30
Date of Preparation: March1st, 2015
Hongshan Liu, Jianhua Zhang, Yong Yuan, Martin Sieber, Chia-Yang Liu, Winston W.-Y.
Kao 3944 - Cell Therapy Of Alkali Burned Cornea With Human Umbilical Mesenchymal
Stem Cells In The Mouse Mode. ARVO annual meeting at Ft. Lauderdale, Florida (May 1-5)
(platform presentation)
2012
Yong Yuan, Chia-Yang Liu, Jeffrey J. Miller, Hongshan Liu, Osamu Yamanaka, William D.
Hardie, Winston W. Kao. 1836/A299 - Doxycycline Induction of TGF-α Overexpression in
Adult Mice Corneal Epithelium Causes Cornea Inflammation and Plateau Iris. ARVO annual
meeting at Ft. Lauderdale, Florida (May 6-10). (poster)
Chia-Yang Liu, Yujin Zhang, Tien Le, Nadean L. Brown, Warren S. Pear, Winston W. Kao
2699 - Role of Canonical Notch Signaling in Ocular Surface Morphogenesis and Disease.
ARVO annual meeting at Ft. Lauderdale, Florida (May 6-10) (Platform presentation)
Osamu Yamanaka, Yong Yuan, Vivien J. Coulson-Thomas, Tarsis F. Gresteira, Yujin Zhang,
Chia-Yang Liu, Shizuya Saika, Winston W. Kao. 3568/D946 - TGFβ Type I Receptor
Mediates the Effects of Lumican on Wound Healing. ARVO annual meeting at Ft.
Lauderdale, Florida (May 6-10) (poster)
Vivien J. Coulson- Thomas, Osamu Yamanaka, Yong Yuan, Tarsis Ferreira Gesteira, ChiaYang Liu, Winston Kao. 4204/A81 - Computational Studies of potential binding sites for
Small Leucine Rich Proteoglycan to Growth Factor Receptors. ARVO annual meeting at Ft.
Lauderdale, Florida (May 6-10) (poster)
Jianhua Zhang, Sr., Hongshan Liu, Yong Yuan, Yujin Zhang, Chia-Yang Liu, Mindy Call,
Minh-Thanh Nguyen, Winston W. Kao. 4738/A49 - Allelic Expression of Tet-On rtTA
Transgenic Driver Mouse Lines in Ocular Surface Tissues. ARVO annual meeting at Ft.
Lauderdale, Florida (May 6-10) (poster)
Yujin Zhang, Lung-Kun Yeh, Winston W-Y Kao, Chia-Yang Liu. 4740/A51 - Conditional
Ablation Of beta-catenin In Keratocytes Triggers Precocious Corneal Morphogenesis During
Development. ARVO annual meeting at Ft. Lauderdale, Florida (May 6-10) (poster)
Minh-Thanh T. Nguyen, Gracia Y. Ng, Leah A. Rosenfeldt, Shannon R. Balser, Ruth
Ashery-Padan, Chia-Yang Liu, Winston W. Kao. 5247 - Ablation of Pax6 in the Basal
Corneal Epithelial Cells Changes the Rate of Desquamation. ARVO annual meeting at Ft.
Lauderdale, Florida (May 6-10) (Platform presentation)
2013
Chia-Yang Liu, Gracia Ng, Lung-Kun Yeh, Hongshan Liu, Yujin Zhang, Winston W. Kao.
Role of Shp2 Protein Phosphatase in Mouse Corneal Epithelium Stratification. ARVO annual
meeting at Seattle WA (May 4-9) (poster presentation)
31
Date of Preparation: March1st, 2015
Yujin Zhang, Lung-Kun Yeh, Winston W.-Y. Kao, Chia-Yang Liu, Conditional ablation of bCatenin in keratocytes triggers precocious corneal morphogenesis during development.
ARVO annual meeting at Seattle WA (May 4-9) (Platform presentation)
2014
Chia-Yang Liu, Yujin Zhang, Lung-Kun Yeh, Winston W.-Y. Kao, Lack of tyrosine
phosphatase Shp2 in corneal epithelium impacts sensory innervation during development
and homeostasis in adult mice. ARVO Annual Meeting, Leading Eye and Vision Research,
May 4-8, 2014, in Orlando, Florida. (poster presentation)
Yujin Zhang, Lung-Kun Yeh, Winston W.-Y. Kao, Chia-Yang Liu, Wnt/b-catenin signaling
controls corneal stroma maturation by repressing TGFbs expression. ARVO Annual Meeting,
Leading Eye and Vision Research, May 4-8, 2014, in Orlando, Florida. (Platform
presentation)
E.
Books, Chapters, Reviews, and Invited papers
I. Book Chapters
1. Griffith, M., Watsky, M.A., Liu, Chia-Yang and Trinkaus-Randall, V. Epithelial cell culture:
Cornea. In: Methods of Tissue Engineering. (A. Atala and R. Lanza, ed.), Academic Press
2001, pp. 131-140.
2. Griffith, M., Trinkaus-Randall, V., Liu, Chia-Yang, Watsky, M.A. and Sheardown, H.D.
Cornea. In: Methods of Tissue Engineering. (A. Atala and R. Lanza, ed.), Academic Press
2001, pp. 927-941.
3. Richard S. Smith, Adriana Zabeleta, Simonn W.M. John, Lesley S. Bechtold, Sakae
Ikeda, MelissaJ. Relyea, John P. Sundberg, Winston W-Y. Kao, and C.-Y. Liu. General and
Special Histopathology. In: Systematic Evaluation of the Mouse Eye. (Richard S. Smith ed.),
CRC Press 2002, pp.265-297
4. Chia-Yang Liu and Winston W.-Y. Kao (2012). Excess Fibroblast Growth Factor-7
Activates β-Catenin and Leads to Ocular Surface Squamous Neoplasia in Mice,
Intraepithelial Neoplasia, Supriya Srivastava (Ed.), ISBN: 978-953-307-987-5, InTech,
Available from: http://www.intechopen.com/articles/show/title/fgf-7-overexpression induces
ocular surface squamous neoplasia in the transgenic mice.
II. Reviews
1. Winston W.-Y. Kao, C.-Y. Liu (2003) The Use of Transgenic and Knock-out mice in the
investigation of Ocular Surface Cell Biology. The Ocular Surface 1: 5-19. PMID: 17075625
2. Tseng SC, Espana EM, Kawakita T, Di Pascuale MA, Li W, He H, Liu TS, Cho TH, Gao
YY, Yeh LK, C.-Y. Liu. (2004) How does amniotic membrane work? The Ocular Surface
2:177-187. PMID: 17216089
3. Kao WW, Funderburgh JL, Xia Y, C.-Y. Liu, Conrad GW. (2006) Focus on molecules:
Lumican. Exp Eye Res. 82:3-4. PMID: 16213485
32
Date of Preparation: March1st, 2015
4. Kao WW, Xia Y, C.-Y. Liu, Saika S. (2008) Signaling pathways in morphogenesis of
cornea and eyelid. The Ocular Surface 6:9-23. PMID: 18264652
5. Hao J, Li SK, Kao WW, C.-Y. Liu (2010) Gene delivery to cornea. Brain Res Bull. 81:25661. PMID: 19560524
6. Kao WW, C.-Y. Liu (2010) Corneal morphogenesis during development and wound
healing. Jpn J Ophthalmol. 54:206-10. PMID: 20577853
7. Yamanaka O, Liu CY, Kao WW (2010) Fibrosis in the anterior segments of the eye.
Endocr Metab Immune Disord Drug Targets. Dec 1;10(4):331-5. Review.
PMID: 20925651
8. Liu CY, Kao WW. (2012) Lumican promotes corneal epithelial wound healing
Methods Mol Biol. 836:285-290. PMID:22252641
9. Liu CY.(2012) Wakayama Symposium: Notch-FoxL2-α-SMA Axis in Eyelid Levator
Muscle Development and Congenital Blepharophimosis. Ocul Surf. 10:221-223. PMID:
23084143
9. DISTRIBUTION OF EFFORT
Indicate percent of time currently spent in bedside teaching, classroom teaching, service or
attending responsibilities, administration, and research (100%).
33