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Appendix 3: Included articles
1. Amr YM, Makharita MY. Comparative study between 2 protocols for management of
severe pain in patients with unresectable pancreatic cancer: one-year follow-up. Clin J
Pain. 2013 Sep;29(9):807-13. doi: 10.1097/AJP.0b013e3182757673. PubMed PMID:
23917696.
2. Basile A, Masala S, Banna G, Cotta E, Cavalli M, Fiumara P, Di Raimondo F, Mundo E,
Scavone G, Granata A, Carrafiello G, Tsetis D. Intrasomatic injection of corticosteroid
followed by vertebroplasty increases early pain relief rather than vertebroplasty alone in
vertebral bone neoplasms: preliminary experience. Skeletal Radiol. 2012 Apr;41(4):45964. doi: 10.1007/s00256-011-1300-6. Epub 2011 Nov 16. PubMed PMID: 22086119
3. Berenson J, Pflugmacher R, Jarzem P, Zonder J, Schechtman K, Tillman JB, Bastian L,
Ashraf T, Vrionis F; Cancer Patient Fracture Evaluation (CAFE) Investigators. Balloon
kyphoplasty versus non-surgical fracture management for treatment of painful vertebral
body compression fractures in patients with cancer: a multicentre, randomised controlled
trial. Lancet Oncol. 2011 Mar;12(3):225-35. doi: 10.1016/S1470-2045(11)70008-0. Epub
2011 Feb 16. PubMed PMID: 21333599
4. Bhatnagar S, Joshi S, Rana SP, Mishra S, Garg R, Ahmed SM. Bedside ultrasoundguided celiac plexus neurolysis in upper abdominal cancer patients: a randomized,
prospective study for comparison of percutaneous bilateral paramedian vs. unilateral
paramedian needle-insertion technique. Pain Pract. 2014 Feb;14(2):E63-8. doi:
10.1111/papr.12107. Epub 2013 Aug 15. PubMed PMID: 23944980.
5. Chiu M, Bryson GL, Lui A, Watters JM, Taljaard M, Nathan HJ. Reducing persistent
postoperative pain and disability 1 year after breast cancer surgery: a randomized,
controlled trial comparing thoracic paravertebral block to local anesthetic
infiltration. Ann Surg Oncol. 2014;21(3):795-801. doi: 10.1245/s10434-013-3334-6.
Epub 2013 Oct 29. PubMed PMID: 24165901; PubMed Central PMCID: PMC3933756.
6. Dahm P, Lundborg C, Janson M, Olegård C, Nitescu P. Comparison of 0.5% intrathecal
bupivacaine with 0.5% intrathecal ropivacaine in the treatment of refractory cancer and
noncancer pain conditions: results from a prospective, crossover, double-blind,
randomized study. Reg Anesth Pain Med. 2000;25(5):480-7. PubMed PMID: 11009233.
7. de Oliveira R, dos Reis MP, Prado WA. The effects of early or late neurolytic
sympathetic plexus block on the management of abdominal or pelvic cancer pain. Pain.
2004;110(1-2):400-8. PubMed PMID: 15275792
8. Doi S, Yasuda I, Kawakami H, Hayashi T, Hisai H, Irisawa A, Mukai T, Katanuma A,
Kubota K, Ohnishi T, Ryozawa S, Hara K, Itoi T, Hanada K, Yamao K. Endoscopic
ultrasound-guided celiac ganglia neurolysis vs. celiac plexus neurolysis: a randomized
multicenter trial. Endoscopy. 2013;45(5):362-9. doi: 10.1055/s-0032-1326225. Epub
2013 Apr 24. PubMed PMID: 23616126.
9. Eisenach JC, DuPen S, Dubois M, Miguel R, Allin D. Epidural clonidine analgesia for
intractable cancer pain. The Epidural Clonidine Study Group. Pain. 1995;61(3):391-9.
PubMed PMID: 7478682.
10. Gamal G, Helaly M, Labib YM. Superior hypogastric block: transdiscal versus classic
posterior approach in pelvic cancer pain.Clin J Pain. 2006;22(6):544-7. PubMed PMID:
16788341
11. Georgiou L, Louizos A, Sklavou C, Manolopoulos L, Yiotakis I, Adamopoulos
G. Cervical versus thoracic epidural morphine for the treatment of head and neck cancer
pain. Ann Otol Rhinol Laryngol. 2000;109(7):676-8. PubMed PMID: 10903050.
12. Gourlay GK, Plummer JL, Cherry DA, Onley MM, Parish KA, Wood MM, Cousins
MJ. Comparison of intermittent bolus with continuous infusion of epidural morphine in
the treatment of severe cancer pain. Pain. 1991;47(2):135-40. PubMed PMID: 1762806.
13. Gress F, Schmitt C, Sherman S, Ikenberry S, Lehman G. A prospective randomized
comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus
block for managing chronic pancreatitis pain. Am J Gastroenterol. 1999;94(4):900-5.
PubMed PMID: 10201454.
14. Hanna MH, Peat SJ, Woodham M, Knibb A, Fung C. Analgesic efficacy and CSF
pharmacokinetics of intrathecal morphine-6-glucuronide: comparison with morphine. Br
J Anaesth. 1990;64(5):547-50. PubMed PMID: 2354092.
15. Ischia S, Ischia A, Polati E, Finco G. Three posterior percutaneous celiac plexus block
techniques. A prospective, randomized study in 61 patients with pancreatic cancer
pain. Anesthesiology. 1992;76(4):534-40. PubMed PMID: 1550278.
16. Jain PN, Shrikhande SV, Myatra SN, Sareen R. Neurolytic celiac plexus block: a better
alternative to opioid treatment in upper abdominal malignancies: an Indian experience. J
Pain Palliat Care Pharmacother. 2005;19(3):15-20. PubMed PMID: 16219607.
17. Johnson CD, Berry DP, Harris S, Pickering RM, Davis C, George S, Imrie CW,
Neoptolemos JP, Sutton R. An open randomized comparison of clinical effectiveness of
protocol-driven opioid analgesia, celiac plexus block or thoracoscopic splanchnicectomy
for pain management in patients with pancreatic and other abdominal
malignancies. Pancreatology. 2009;9(6):755-63. doi: 10.1159/000199441. Epub 2010 Jan
15. PubMed PMID: 20090396.
18. Kalso E, Heiskanen T, Rantio M, Rosenberg PH, Vainio A. Epidural and subcutaneous
morphine in the management of cancer pain: a double-blind cross-over study. Pain.
1996;67(2-3):443-9. PubMed PMID: 8951940.
19. Kawamata M, Ishitani K, Ishikawa K, Sasaki H, Ota K, Omote K, Namiki
A. Comparison between celiac plexus block and morphine treatment on quality of life in
patients with pancreatic cancer pain. Pain. 1996;64(3):597-602. PubMed PMID:
8783327.
20. King H, Xiao CS, Wooten DJ. Prolongation of epidural bupivacaine analgesia with
glycerin. Can J Anaesth. 1993;40(5 Pt 1):431-4. PubMed PMID: 8513522.
21. Korovessis P, Vardakastanis K, Vitsas V, Syrimpeis V. Is Kiva implant advantageous to
balloon kyphoplasty in treating osteolytic metastasis to the spine? Comparison of 2
percutaneous minimal invasive spine techniques: a prospective randomized controlled
short-term study. Spine (Phila Pa 1976). 2014; 15;39(4):E231-9. doi:
10.1097/BRS.0000000000000112. PubMed PMID: 24253785.
22. Lauretti GR, Rizzo CC, Mattos AL, Rodrigues SW. Epidural methadone results in dosedependent analgesia in cancer pain, further enhanced by epidural dexamethasone. Br J
Cancer. 2013;108(2):259-64. doi: 10.1038/bjc.2012.593. Epub 2013 Jan 15. PubMed
PMID: 23322191; PubMed Central PMCID: PMC3566815.
23. Lauretti GR, Gomes JM, Reis MP, Pereira NL. Low doses of epidural ketamine or
neostigmine, but not midazolam, improve morphine analgesia in epidural terminal cancer
pain therapy. J Clin Anesth. 1999;11(8):663-8. PubMed PMID: 10680109.
24. LeBlanc JK, Al-Haddad M, McHenry L, Sherman S, Juan M, McGreevy K, Johnson C,
Howard TJ, Lillemoe KD, DeWitt J. A prospective, randomized study of EUS-guided
celiac plexus neurolysis for pancreatic cancer: one injection or two? Gastrointest Endosc.
2011;74(6):1300-7. doi: 10.1016/j.gie.2011.07.073. Epub 2011 Oct 13. PubMed PMID:
22000795.
25. Leblanc JK, Rawl S, Juan M, Johnson C, Kroenke K, McHenry L, Sherman S, McGreevy
K, Al-Haddad M, Dewitt J. Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in
Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL
Alcohol. Diagn Ther Endosc. 2013;2013:327036. doi: 10.1155/2013/327036. Epub 2013
Jan 8. PubMed PMID: 23365492; PubMed Central PMCID: PMC3556397.
26. Lillemoe KD, Cameron JL, Kaufman HS, Yeo CJ, Pitt HA, Sauter PK. Chemical
splanchnicectomy in patients with unresectable pancreatic cancer. A prospective
randomized trial. Ann Surg. 1993;217(5):447-55; discussion 456-7. PubMed PMID:
7683868; PubMed Central PMCID: PMC1242819.
27. Liu HJ, Gao XZ, Liu XM, Xia M, Li WY, Jin Y. Effect of intrathecal dexmedetomidine
on spinal morphine analgesia in patients with refractory cancer pain. J Palliat Med.
2014;17(7):837-40. doi: 10.1089/jpm.2013.0544. Epub 2014 Apr 4. PubMed PMID:
24702571.
28. Mercadante S. Celiac plexus block versus analgesics in pancreatic cancer pain. Pain.
1993;52(2):187-92. PubMed PMID: 8455966
29. Mishra S, Bhatnagar S, Rana SP, Khurana D, Thulkar S. Efficacy of the anterior
ultrasound-guided superior hypogastric plexus neurolysis in pelvic cancer pain in
advanced gynecological cancer patients. Pain Med. 2013;14(6):837-42. doi:
10.1111/pme.12106. Epub 2013 Apr 11. PubMed PMID: 23577819.
30. Moulin DE, Max MB, Kaiko RF, Inturrisi CE, Maggard J, Yaksh TL, Foley KM. The
analgesic efficacy of intrathecal D-Ala2-D-Leu5-enkephalin in cancer patients with
chronic pain. Pain. 1985;23(3):213-21. PubMed PMID: 3906516.
31. Pasqualucci V, Tantucci C, Paoletti F, Dottorini ML, Bifarini G, Belfiori R, Berioli MB,
Grassi V, Sorbini CA. Buprenorphine vs. morphine via the epidural route: a controlled
comparative clinical study of respiratory effects and analgesic activity. Pain.
1987;29(3):273-86. PubMed PMID: 3614964.
32. Smith TJ, Coyne PJ, Staats PS, Deer T, Stearns LJ, Rauck RL, Boortz-Marx RL, Buchser
E, Català E, Bryce DA, Cousins M, Pool GE. An implantable drug delivery system
(IDDS) for refractory cancer pain provides sustained pain control, less drug-related
toxicity, and possibly better survival compared with comprehensive medical management
(CMM). Ann Oncol. 2005;16(5):825-33. Epub 2005 Apr 7. PubMed PMID: 15817596.
33. Staats PS, Yearwood T, Charapata SG, Presley RW, Wallace MS, Byas-Smith M, Fisher
R, Bryce DA, Mangieri EA, Luther RR, Mayo M, McGuire D, Ellis D. Intrathecal
ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a
randomized controlled trial. JAMA. 2004;291(1):63-70. PubMed PMID: 14709577.
34. Süleyman Ozyalçin N, Talu GK, Camlica H, Erdine S. Efficacy of coeliac plexus and
splanchnic nerve blockades in body and tail located pancreatic cancer pain. Eur J Pain.
2004;8(6):539-45. PubMed PMID: 15531222.
35. Vainio A, Tigerstedt I. Opioid treatment for radiating cancer pain: oral administration vs.
epidural techniques. Acta Anaesthesiol Scand. 1988;32(3):179-85. PubMed PMID:
3284266