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OIE Collaborating Centre Reports
Activities in 2012
Title of Collaborating Centre:
Address of Collaborating Centre:
Research and Training in Population
Animal Health Diagnosis and
Surveillance Systems
Technical University of Denmark,
National Veterinary Institute,
International EpiLab
Bülowsvej 27, DK-1790 Copenhagen
V, Denmark
Tel.:
(45) 35 88 60 00
Fax:
(45) 35 88 60 01
e-mail address:
[email protected]
website:
www.vet.dtu.dk
Name of Director of Institute
(Responsible Official):
Kristian Møller
Name (including Title and
Position) of Head of the
Collaborating Centre (formally
OIE Contact Point):
Claes Enøe, DVM, PhD, Dipl.
ECVPH, Senior Researcher, Section
for Epidemiology
Name (including Title and
Position) of writer of this report
(if different from above)
Annual reports of OIE Reference Centres, 2012
1
Research and Training in Population Animal Health Diagnosis and Surveillance Systems
Summary of activities specifically related to the mandate of
OIE Collaborating Centres
1.
Activities as a centre of research, expertise, standardisation and dissemination of
techniques within the remit of the mandate given by the OIE
1.
The National Veterinary Institute is project leader of the research project “Optimizing the control of
foot-and-mouth disease in Denmark by simulation“ that were completed mid 2012. This project
included a scientific network including: the National Veterinary Institute, Technical University of
Denmark; Informatics and Mathematical Modelling, Technical University of Denmark; the Institute
of Food and Resource Economics, University of Copenhagen, LIFE; the Danish Veterinary and Food
Administration, Ministry of Family and Consumer Affairs; Center for Animal Disease Modeling and
Surveillance, University of California, Davis; Centers for Epidemiology and Animal Health, USDA,
Fort Collins, Colorado; and the livestock industries, Danish Meat Association and Danish Dairy
Board, Danish Cattle Federation.
The results from the project are in the process of being published. They will among other issues cover
how the time to detection of the first case of FMD influences the size of the epidemic outbreak.
2.
The National Veterinary Institute participates as partner in the consortium FMD-DISCONVAC.
FMD-DISCONVAC is a small collaborative project funded by the European Commission within the
7th Framework Programme for Research and Technological Development. The aim of the project is
to improve and/or develop vaccine against foot-and-mouth disease, including vaccination strategies
and diagnostics assays for field use. The project has started 1st of April 2009 and will end mid 2013.
http://fmddisconvac.net/.
As part of this project it was investigated if the size of an FMD outbreak on day 14 after the detection
of the first case can predict the size og the epidemic. This is in the process of being published.
3.
The National Veterinary Institute is project leader of the research project “Optimizing the
surveillance of diseases in cattle”. This project includes a Ph.D.-study. The project is funded by the
Danish Dairy Board, Danish Cattle Federation and by ‘Innovationsloven’ – a national funding body.
The aim of the project is to evaluate and optimize existing surveillance programs primarily based on
bulk tank milk testing in dairy cattle herds. Additionally, surveillance programs for other diseases are
considered. The model disease is BVDV but the expected outcome from the project is generic and
should cover all relevant diseases. The project started 1July 2010 and will run for at least 3 years.
The project has this far resulted in new insight in the limitations of bulk milk testing, the within herd
spread and the implications for herd level testing and how this will influence the probability of testing
freedom from infection at the herd level. The results from this study are going to be published over
the next year.
4.
The Danish National Centre for Wildlife Health which is part of the section for epidemiology at the
National Veterinary Institute carried out a survey of intestinal parasites in the common eider
(Somateria mollissima) in 2010-2012. The gastrointestinal tracts from a total of 157 eiders were
examined and the intestinal parasites were characterized. The results from this survey are in the
process of being published.
Additionally, in the first half of 2012 the Danish National Centre for Wildlife Health examined 206
wild mammals and 26 wild birds for wild life diseases and the cause of dead.
A web based survey of the occurrence of diarrhea in roe deer is running and has shown potential as a
mean of collecting real time surveillance data on wild life. However, there are some unresolved
issues regarding the statistical analyses based on these data.
An active surveillance for intestinal parasites was conducted in raccoon dogs (45) and foxes (290).
As a result from this program Echinococcus multilocularis was found in a fox in March 2012.
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Annual reports of OIE Reference Centres, 2012
Research and Training in Population Animal Health Diagnosis and Surveillance Systems
5.
The National Veterinary Institute is developing methods for risk based surveillance of vector borne
diseases. Biting midges, mosquitoes and ticks were sampled throughout Denmark during 2012 with
the objective to identify spatial and temporal hot spots suitable for targeting surveillance of vector
borne diseases.
During these surveillance activities emerging Schmallenberg virus was detected in biting midges
(Rasmussen, L.D., Kristensen B., Kirkeby C., Rasmussen T.B., Belsham G., Bødker R., Bøtner A.,
2012. Culicoids as Vectors of Schmallenberg Virus. Emerging Infectious Diseases (DOI:
http://dx.doi.org/10.3201/eid1807.120385), vol: 18, issue: 7). and Candidatus Neoehrlichia
mikurensis was detected in ticks for the first time in Denmark (Fertner M.E., Mølbak, M., Boye Pihl,
T.P., Fomsgaard, A., Bødker, R., 2012. First detection of tick-borne “Candidatus Neoehrlichia
mikurensis” in Denmark 2011. Eurosurveillance, vol: 17, issue: 8.).
Models of spread of Culicoides borne diseases were developed to identify risk areas (Græsbøll, K.,
Bødker, R., Enøe, C., Christiansen, L.E., 2012. Simulating spread of bluetongue virus by flying
vectors between hosts on pasture. Scientific Reports, 2).
The National Veterinary Institute is coordinating a new EMIDA funded research project with eight
European partners (VICE-Risk Based surveillance for Vector Borne Disease). VICE is developing
veterinary risk based surveillance systems based on three independent measures i) the risk of
introduction ii) the potential for transmission given an introduction and iii) syndromic surveillance.
6.
In 2011-12 the National Veterinary Institute performed a risk evaluation on the possible geographic
clustering of pH1N1-infected swine herds in Denmark. There were 16 infected herds and 229 control
herds from mainland Jutland, and clustering was assessed globally according to Cuzick & Edwards
and locally by SatScan technique. It was concluded, that there was no evidence of geographic
clustering and thus no evidence that herds close to pH1N1-infected herds were at larger risk of
contracting disease.
The Danish Veterinary Administration forwarded the risk evaluation to the Chinese Veterinary
Austhorities, and after discussions in China by mid 2012, it was recommended that the 50 km
restriction zones around pH1N1-infected swine herds in Denmark should be lifted.
2.
Proposal or development of any procedure that will facilitate harmonisation of international
regulations applicable to the surveillance and control of animal diseases, food safety or
animal welfare
None
3.
Networking
a)
Maintenance of a network with other OIE Collaborating Centres designated for the same
specialty, and
In the project mentioned above in paragraph 1, we have established collaboration with Centres for
Epidemiology and Animal Health, USDA-APHIS-VS-CEAH 2150 Centre Ave, Building B Fort Collins,
CO 80526-8117 USA, that is a OIE collaborating centre for Animal Disease Surveillance Systems, Risk
Analysis and Epidemiological Modelling.
b)
Should the need arise, maintenance of a network with Collaborating Centres in other
disciplines
None
Annual reports of OIE Reference Centres, 2012
3
Research and Training in Population Animal Health Diagnosis and Surveillance Systems
4.
Placement of expert consultants at the disposal of the OIE
None
5.
Provision of scientific and technical training, within the remit of the mandate given by the
OIE, to personnel from OIE Member Countries
None
6.
Organisation of scientific meetings on behalf of the OIE
None
7.
Coordination of scientific and technical studies in collaboration with other laboratories,
organisations or collaborating centres
None
8.
Publication and dissemination of any information within the remit of the mandate given by
the OIE that may be useful to Member Countries of the OIE
Rasmussen, L.D., Kristensen B., Kirkeby C., Rasmussen T.B., Belsham G., Bødker R., Bøtner A., 2012.
Culicoids
as
Vectors
of Schmallenberg Virus.
Emerging Infectious
Diseases
(DOI:
http://dx.doi.org/10.3201/eid1807.120385), vol: 18, issue: 7.
Fertner M.E., Mølbak, M., Boye Pihl, T.P., Fomsgaard, A., Bødker, R., 2012. First detection of tick-borne
“Candidatus Neoehrlichia mikurensis” in Denmark 2011. Eurosurveillance, vol: 17, issue: 8.
Græsbøll, K., Bødker, R., Enøe, C., Christiansen, L.E., 2012. Simulating spread of bluetongue virus by flying
vectors between hosts on pasture. Scientific Reports, 2.
_______________
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Annual reports of OIE Reference Centres, 2012