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Ministero della Salute Direzione Generale Ricerca Scientifica e Tecnologica BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1 RF‐2009‐1473239 Development of Alzheimer disease therapeutics based on a natural variant of amyloid‐beta that hinders amyloidogenesis 5 biomedica Brain Disorders and Clinical Neuroscience € 590.700,00 2 RF‐2009‐1501881 Micro‐RNA Regulated Gene Transfer for Treatment of Autoimmune Diseases 5 biomedica Immunology € 600.000,00 3 RF‐2009‐1525539 BLOOD PRESSURE CONTROL AND CARDIOVASCULAR RISK MANAGEMENT IN HIGH RISK HYPERTENSIVE PATIENTS. CLINICAL EFFICACY AND FEASIBILITY OF HOME TELEMONITORING. 5,5 clinico assistenziale Healthcare Delivery and Methodologies € 597.000,00 4 RF‐2009‐1528187 Development of osteoinductive micro and nano structured polymer surfaces for bone replacement 5,5 biomedica Bioengineering Sciences and Technologies € 275.000,00 5 RF‐2009‐1530177 Cognitive, imaging and genetic predictors of behavioral disturbances in Parkinsons disease 5,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 387.000,00 6 RF‐2009‐1549619 Role of alpha6 nicotinic receptor subunit in tobacco dependence 6 biomedica Brain Disorders and Clinical Neuroscience € 590.000,00 7 RF‐2009‐1526759 Role of autophagy in neuromuscular diseases 6 biomedica Cell Biology € 400.000,00 8 GR‐2009‐1607206 Allergic components in experimental multiple sclerosis: novel targets for immune intervention 6 biomedica Immunology € 584.100,00 9 RF‐2009‐1532793 ITALIAN MULTICENTRE RANDOMIZED CLINICAL TRIAL ON SUBLICNICAL ACUTE REJECTION IN KIDNEY TRASNPLANT RECIPIENTS 6 clinico assistenziale Immunology € 275.000,00 10 RF‐2009‐1499374 Analysis and manipulation of LXR signaling to induce successful antitumor responses 6 biomedica Immunology € 430.000,00 Pagina 1 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 11 RF‐2009‐1498890 Epigenetic control of breast cancer progression: animal and clinical studies 6 biomedica Biobehavioral and Behavioral Processes € 398.970,00 12 RF‐2009‐1499542 Induced pluripotent stem cells (iPSC) in the treatment of TCIRG1‐dependent osteopetrosis: a step by step reproduction of the entire therapeutic process in the mouse 6 biomedica Genes, Genomes and Genetics € 460.000,00 13 GR‐2009‐1607070 Self‐Extinction of Stem Cells and the Spontaneous Regression/Dormancy of Breast Cancer 6,17 biomedica Oncology 1 ‐ Basic Translational € 556.600,00 14 RF‐2009‐1532281 Role of delta16HER2 splice variant in tumor progression and in response to biodrugs targeting HER2 receptor 6,25 biomedica Oncology 1 ‐ Basic Translational € 489.500,00 15 GR‐2009‐1608780 Positron Emission Tomography (PET)/Computerized Tomography (CT) and Magnetic Resonance Imaging (MRI) fusion for the in vivo characterization of atherosclerotic plaques at risk 6,3 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 600.000,00 16 RF‐2009‐1551083 INTERACTION FRAMEWORK BETWEEN PATIENT ADVOCACY GROUPS AND CANCER CENTERS ON SARCOMAS, AS A MODEL FOR RARE CANCERS 6,5 clinico assistenziale Healthcare Delivery and Methodologies € 451.000,00 17 RF‐2009‐1535329 SILS‐Study (Single Incision Laparoscopic Surgery Study) 6,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 225.000,00 18 RF‐2009‐1524170 Uncovering the genetic footprint of T cells residing in the pancreatic draining lymph nodes of patients with type 1 diabetes 6,5 biomedica Immunology € 450.000,00 19 GR‐2009‐1576820 ENVIROMENTAL, GENETIC AND EPIGENETIC COMPONENTS IN DRUG ABUSE AND RELAPSE TO DRUG‐SEEKING 6,5 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 20 RF‐2009‐1545998 SNAP25 heterozygous mice as models to identify a safer pharmacological treatment for ADHD 6,5 biomedica Brain Disorders and Clinical Neuroscience € 397.500,00 21 RF‐2009‐1472600 Treatment optimization of HER2 positive breast cancer 6,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 535.000,00 22 RF‐2009‐1474272 Investigation of the specific role for mGlu2 and mGlu3 metabotropic glutamate receptors in chronic pain. 6,5 biomedica Integrative, Functional, and Cognitive Neuroscience € 294.000,00 Pagina 2 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 23 RF‐2009‐1525460 Study of coagulation and tumor‐associated neutrophils in intestinal cancer development. 6,75 biomedica Immunology € 583.300,00 24 GR‐2009‐1529671 Definition of magnetic resonance imaging (MRI) biomarkers of cognitive impairment in multiple sclerosis patients with different disease phenotypes, from childhood to adulthood: application and integration of structural and functional MR‐based techniques 6,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 600.000,00 25 GR‐2009‐1579849 Novel approaches to imaging and treatment of epilepsy: virus‐like striped nanoparticles. 7 biomedica Bioengineering Sciences and Technologies € 554.400,00 26 RF‐2009‐1548152 Analysis of the iNKT cell‐DCs crosstalk for tolerance induction and prevention of autoimmune Type 1 Diabetes 7 biomedica Immunology € 467.000,00 27 GR‐2009‐1600315 Ruvbl‐1 in the pathogenesis of Hepatocellular Carcinoma. 7 biomedica Oncology 1 ‐ Basic Translational € 347.000,00 28 RF‐2009‐1547114 Parameter invariant TCP‐NTCP Radiotherapy Plan Ranking 7 biomedica Oncology 2 ‐ Translational Clinical € 484.000,00 29 GR‐2009‐1605759 Potential involvement of the atypical amino acid D‐aspartate in schizophrenia 7 biomedica Brain Disorders and Clinical Neuroscience € 512.000,00 30 RF‐2009‐1530290 HMGB1 blockade as a therapeutic tool in Systemic Lupus Erythematosus 7 biomedica Musculoskeletal, Oral and Skin Sciences € 580.000,00 31 RF‐2009‐1530493 NEXT‐GENERATION DNA SEQUENCING IN DEEP VEIN THROMBOSIS 7 biomedica Vascular and Hematology € 314.600,00 32 RF‐2009‐1538880 Development of innovative methods for the detection of pathogenic bacteria in fresh vegetables and in irrigation and washing water of crops 7 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 33 RF‐2009‐1506142 Toll‐like receptors at the intersection between infection and seizures: role in epileptogenesis and in developmental epilepsy 7 biomedica Brain Disorders and Clinical Neuroscience € 450.000,00 34 GR‐2009‐1600051 Exploring Opa1‐dependent mitochondrial cristae remodelling as a therapeutic target in cancer 7 biomedica Cell Biology € 600.000,00 Pagina 3 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 35 GR‐2009‐1596824 Modelling and treatment of cystic fibrosis through an integrated Systems Biology approach 7 biomedica Cardiovascular and Respiratory Sciences € 591.840,00 36 GR‐2009‐1594678 In pursuit of novel neuroprotective strategies for Parkinsons disease: understanding the role of PINK1 in regulating autophagy and apoptosis 7 biomedica Molecular, Cellular, and Developmental Neuroscience € 523.800,00 37 GR‐2009‐1596786 GENETIC VARIANTS AND SUSCEPTIBILITY TO SEVERE AND/OR RECURRENT LOWER RESPIRATORY TRACT INFECTIONS WITH WHEEZING IN CHILDREN 7 clinico assistenziale Infectious Diseases and Microbiology € 600.000,00 38 RF‐2009‐1491608 Role of p53/p63/p73 family in breast cancer stem cells 7 biomedica Oncology 1 ‐ Basic Translational € 283.000,00 39 RF‐2009‐1470484 Mechanisms of de‐regulation of self‐renewal and differentiation in cancer stem cells 7 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 40 RF‐2009‐1474758 The novel emergence of atypical animal and human TSEs. A clinical, pathological, molecular, and experimental approach to define interspecies similarities and strain connections 7 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 41 RF‐2009‐1525703 Mechanism of action and in vivo efficacy of old and new glucocorticoids and new combination treatments for an improved outcome of spinal cord injury 7,25 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 42 GR‐2009‐1603126 Development of innovative preclinical mouse models to define the molecular mechanisms of trasformation of Anaplastic Large T‐cell Lymphoma 7,25 biomedica Oncology 2 ‐ Translational Clinical € 296.000,00 43 GR‐2009‐1608935 Study of Radiobiological and Radiotherapic Effects of a Novel Laser Driven Electron Accelerator 7,25 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 44 RF‐2009‐1530527 Health technology assessment of needlestick‐prevention devices to enhance safety of health care workers 7,25 clinico assistenziale Healthcare Delivery and Methodologies € 210.000,00 45 RF‐2009‐1474624 The zoonotic potential of Transmisible Spongiform Encephalopathies 7,25 biomedica Brain Disorders and Clinical Neuroscience € 597.550,00 46 RF‐2009‐1525236 Targeting HMGB1 in inflammation‐associated tumors 7,34 biomedica Oncology 1 ‐ Basic Translational € 406.333,00 Pagina 4 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 47 GR‐2009‐1605007 Novel nanostructured coating for dental implants and prostheses with high osseointegration efficiency 7,5 biomedica Musculoskeletal, Oral and Skin Sciences € 525.000,00 48 RF‐2009‐1539841 Molecular bases and pathogenic mechanisms of hereditary spinocerebellar degenerations caused by defects of mitochondrial protein quality control 7,5 biomedica Brain Disorders and Clinical Neuroscience € 352.300,00 49 GR‐2009‐1604984 Design, development and pilot clinical application of innovative biofeedback systems for multidisciplinary motor rehabilitation in Parkinsons Disease 7,5 biomedica Musculoskeletal, Oral and Skin Sciences € 248.000,00 50 RF‐2009‐1524245 Allotransplantation of mesoangioblasts for Duchenne Muscular Dystrophy: a phase I/II clinical trial. 7,5 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 580.000,00 51 GR‐2009‐1606660 Investigation of novel predictors of response to antiangiogenic treatments in hepatocellular carcinoma: Contrast‐Enhanced Ultrasonography (CEUS), VEGFR2‐ targeted CEUS and elastosonography 7,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 152.500,00 52 GR‐2009‐1606736 Effect on professional practice and health care outcomes of computerized evidence‐based information system and clinical decision support: a randomized controlled trial in orthopedics 7,5 clinico assistenziale Healthcare Delivery and Methodologies € 423.576,00 53 RF‐2009‐1526404 Metabolic defects in stem cells as major causes of age‐related diseases 7,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 479.600,00 54 GR‐2009‐1579812 Functional and genetic dissection of Pseudomonas aeruginosa and host response to respiratory infection 7,5 biomedica Infectious Diseases and Microbiology € 580.000,00 55 GR‐2009‐1607360 Promote self‐other merging in Autism Spectrum Conditions by combined behavioural manipulation and Noninvasive Brain Stimulation. 7,5 clinico assistenziale Brain Disorders and Clinical Neuroscience 56 RF‐2009‐1539582 A multicenter randomised trial of contrast‐enhanced MR imaging as a breast cancer screening tool in addition to mammography and ultrasonography in women at intermediate risk. Feasibility, and short term results. 7,5 biomedica Healthcare Delivery and Methodologies € 565.000,00 57 RF‐2009‐1543548 Metabotropic glutamate receptors: new targets for the treatment of autoimmune disorders of the Central Nervous System 7,5 biomedica Immunology € 300.000,00 € 425.150,00 Pagina 5 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 58 RF‐2009‐1528677 TRANSCRANIAL STIMULATION FOR INDUCING SLEEP: Effectiveness of tDCS and TMS techniques 7,5 biomedica Integrative, Functional, and Cognitive Neuroscience € 263.429,00 59 RF‐2009‐1531842 Mechanisms of immune surveillance of prostate cancer by CD1d‐restricted invariant NKT cells 7,5 biomedica Immunology € 400.000,00 60 RF‐2009‐1536665 Impact of engineered nanoparticles on reproductive health and embryonic development 7,5 biomedica Bioengineering Sciences and Technologies € 325.000,00 61 RF‐2009‐1526102 Randomized, multi‐center, open‐label, study of monotherapy with darunavir/ritonavir or lopinavir/ritonavir vs. standard of care in virologically suppressed HIV‐infected patients. 7,5 clinico assistenziale AIDS and Related Research € 600.000,00 62 RF‐2009‐1547384 DESIGN OF A CLINICAL TRIAL USING CD133‐LV(U7) 7,5 clinico assistenziale Genes, Genomes and Genetics € 671.000,00 63 RF‐2009‐1475235 Motor neuron death in Spinal Muscular Atrophy (SMA): new animal models and innovative therapeutic strategies 7,5 biomedica Brain Disorders and Clinical Neuroscience € 594.000,00 64 RF‐2009‐1471694 Lentiviral vectors and cell permeable peptides against Ras‐GRF and ERK signalling to treat L‐DOPA induced Dyskinesia 7,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 600.000,00 65 RF‐2009‐1469691 BONE MARROW AS AN ALTERNATIVE SITE FOR ISLET TRANSPLANTATION IN PATIENTS WITH TYPE 1 DIABETES 7,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 600.000,00 66 RF‐2009‐1524077 DISEASE MODIFIERS AND NOVEL THERAPEUTIC TARGETS FOR ALTERED TISSUE REPAIR IN DYSTROPHIC EPIDERMOLYSIS BULLOSA 7,67 biomedica Musculoskeletal, Oral and Skin Sciences € 420.000,00 67 RF‐2009‐1471624 Chronic rejection in kidney transplantation: identification of new diagnostics targets 7,67 biomedica Immunology € 410.000,00 68 GR‐2009‐1580594 Beyond the use of autologous graft for urethral stricture repair: a novel application of stem cell in urethral tissue reconstruction. 7,75 clinico assistenziale Bioengineering Sciences and Technologies € 305.000,00 Pagina 6 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 69 GR‐2009‐1606801 Innovative approaches for diagnosis and treatment of B‐cell Chronic Lymphocytic Leukemia 7,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 500.000,00 70 RF‐2009‐1550218 A novel 3D bioreactor for in vitro platelet production: a translational research strategy to support platelet supply problems in patients undergoing chemotherapy and/or receiving autologous stem cells. 7,75 biomedica Oncology 2 ‐ Translational Clinical € 578.000,00 71 RF‐2009‐1485896 Combined Gene and Cell Therapy Approaches for the Treatment of Primary Immunodeficiencies 7,75 biomedica Genes, Genomes and Genetics € 580.000,00 72 RF‐2009‐1475845 Induction of long‐term synaptic plasticity in the human cerebellum by repetitive TMS: cellular mechanisms and implications for rehabilitation in ataxia 7,75 biomedica Integrative, Functional, and Cognitive Neuroscience € 374.000,00 73 RF‐2009‐1524462 Role of protein misfolding in the pathogenesis of Niemann‐Pick type C disease: a possible therapeutic target 7,84 biomedica Brain Disorders and Clinical Neuroscience € 444.500,00 74 RF‐2009‐1549561 Impact of Modified Intention to Treat Reporting on Treatment Effect in Meta‐ analyses: A Meta‐Epidemiological Study 8 clinico assistenziale Healthcare Delivery and Methodologies € 65.000,00 75 GR‐2009‐1605077 Dosimetric and methodological evaluation of the novel PET amyloid tracer 18F‐ FDDNP 8 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 200.000,00 76 RF‐2009‐1524017 Use of nanoparticles overcoming the blood‐brain barrier in the treatment of the mouse model of the Krabbe Disease severe form. 8 biomedica Molecular, Cellular, and Developmental Neuroscience € 367.000,00 77 RF‐2009‐1545081 Isolated Hemihyperplasia, a pediatric cancer risk disease: search for genetic/epigenetic mechanisms involved in its pathogenesis 8 biomedica Genes, Genomes and Genetics € 462.000,00 78 RF‐2009‐1529710 Population based comparisons of cancer burden indicators 8 clinico assistenziale Population Sciences and Epidemiology € 438.889,00 79 RF‐2009‐1550308 Study of the molecular, biochemical and metabolic mechanisms involved in the cardioprotective effect of T3 8 biomedica Cardiovascular and Respiratory Sciences € 385.000,00 80 GR‐2009‐1608032 Functional characterization of the circulating B cell compartment in rheumatoid arthritis: relationship with clinical remission and sub‐clinical disease activity 8 biomedica Musculoskeletal, Oral and Skin Sciences € 441.200,00 Pagina 7 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 81 GR‐2009‐1570296 The relationship among food, mycotoxins, gastrointestinal disorders and autism: a multidisciplinary approach for the molecular investigation. 8 biomedica Brain Disorders and Clinical Neuroscience € 594.000,00 82 RF‐2009‐1474648 Resistance to kinase Inhibitors in cancer therapy and in target validation 8 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 83 RF‐2009‐1469718 Role of mitochondrial dynamics in myogenesis and in the therapeutic action of Nitric Oxide in muscular dystrophy 8 biomedica Musculoskeletal, Oral and Skin Sciences € 228.800,00 84 RF‐2009‐1471003 Phospholipid homeostasis and endosomal dynamics in neurodegenerative disorders of the central and peripheral nervous system 8 biomedica Molecular, Cellular, and Developmental Neuroscience € 500.000,00 85 RF‐2009‐1473623 Modeling glioma progression and oncogene addiction in vivo to identify and challenge new therapeutic targets 8 biomedica Oncology 1 ‐ Basic Translational € 460.000,00 86 RF‐2009‐1470083 Gene therapy for beta‐thalassemia: studies of efficacy and safety 8 biomedica Genes, Genomes and Genetics € 500.000,00 87 RF‐2009‐1473000 Enhanced cell therapy of peripheral artery disease: improving survival and engraftment of transplanted endothelial cells by cell protection from oxidative stress. 8 biomedica Vascular and Hematology € 550.000,00 88 RF‐2009‐1498841 Platelet Rich Plasma, from clinical application to research and back: a new non‐ surgical bioactive treatment for knee cartilage degeneration and osteoarthritis. 8 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 600.000,00 89 RF‐2009‐1499302 models of atlastin function and dysfunction 8 biomedica Cell Biology € 383.000,00 90 RF‐2009‐1472661 The Role of Adipose Triglyceride Lipase (ATGL) in the Intracellular Muscle and Adipocyte Lipid Metabolism: the Model of Neutral Lipid Storage Disease with Myopathy (NLSDM) 8 biomedica Musculoskeletal, Oral and Skin Sciences € 400.000,00 91 RF‐2009‐1504409 LONG‐TERM PROGNOSIS OF OLDER PATIENTS AFTER HOSPITAL ADMISSION: ROLE OF PHYSICAL PERFORMANCE MEASURES, INFLAMMATORY MARKERS AND ADMINISTRATIVE DATA 8 clinico assistenziale Biology of Development and Aging 92 RF‐2009‐1473187 Mitochondrial Carrier Diseases: Clinical prevalence, study of mechanisms, and possible therapies 8 biomedica Brain Disorders and Clinical Neuroscience € 151.850,00 € 396.000,00 Pagina 8 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 93 GR‐2009‐1580495 Quantitative proteomics to decipher the molecular code of protein methylation: the dynamic methylome dissected by MS and its role in cancer 8,17 biomedica Biological Chemistry and Macromolecular Biophysics € 423.300,00 94 RF‐2009‐1475861 A POTENTIAL IRON‐LIPID METABOLISM CONNECTION REVEALED BY STUDIES OF HEPCIDIN REGULATION: RELEVANCE TO IRON DISORDERS AND METABOLIC SYNDROME 8,17 biomedica Vascular and Hematology € 310.000,00 95 RF‐2009‐1492700 Dissecting the Role of Autophagy in HCV‐induced Steatosis 8,17 biomedica Infectious Diseases and Microbiology 96 GR‐2009‐1606229 Folate metabolism, epigenetics, and Alzheimers disease 8,25 biomedica Brain Disorders and Clinical Neuroscience € 231.677,00 97 RF‐2009‐1511294 The role of alloreactive natural killer (NK) cells in children with hematological malignancies given a T‐cell depleted haematopoietic stem cell transplantation (HSCT) from an HLA‐disparate relative. 8,25 biomedica Oncology 2 ‐ Translational Clinical € 599.500,00 98 RF‐2009‐1539631 New and emerging vector borne infectious diseases in Italy: epidemiology, surveillance, diagnosis and impact on the safety of blood and organ donations. 8,25 clinico assistenziale Infectious Diseases and Microbiology € 300.000,00 99 RF‐2009‐1547884 Cortical stimulation in the study of time processing and anosognosia in brain damaged patients 8,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 300.000,00 100 GR‐2009‐1594913 Gene therapy for inborn errors of metabolism 8,25 biomedica Genes, Genomes and Genetics € 580.800,00 101 GR‐2009‐1591615 NEurocontrolled MEchatronic prostheSIS (NEMESIS) 8,25 biomedica Emerging Technologies and Training in Neurosciences € 586.000,00 102 GR‐2009‐1594645 Subthalamic Nucleus Deep Brain Stimulation in Tourettes Syndrome 8,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 273.900,00 103 RF‐2009‐1470310 Objective diagnosis of the hearing functionality and of the hearing loss susceptibility in workers exposed to noise and/or ototoxic agents, by development of advanced techniques for the acquisition and analysis of otoacoustic emissions. Evaluation of the 8,25 biomedica Bioengineering Sciences and Technologies € 476.000,00 € 513.516,00 Pagina 9 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 104 RF‐2009‐1492481 Ita‐MNGIE: An Italian network for MNGIE epidemiology, molecular mechanisms and enzyme replacement therapy by stem cell transplant 8,25 clinico assistenziale Genes, Genomes and Genetics € 300.000,00 105 RF‐2009‐1473326 Sensori‐motor Integration. Physiology and Pathophysiology. 8,34 biomedica Integrative, Functional, and Cognitive Neuroscience € 455.500,00 106 RF‐2009‐1505746 Prevention of anthracycline‐induced cardiotoxicity: a multicentre randomized trial 8,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 582.000,00 107 RF‐2009‐1537760 Borrelia infection and mantle cell lymphoma: a pathogenic association of clinico‐ therapeutic relevance 8,5 biomedica Oncology 1 ‐ Basic Translational € 512.600,00 108 RF‐2009‐1505517 A sequencing based genome wide association scan for autoimmunity in Sardinia 8,5 biomedica Genes, Genomes and Genetics € 300.000,00 109 RF‐2009‐1546787 Right ventricular adaptiation in pulmonary arterial hypertension: the interplay between shape and myocardial injury 8,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 298.600,00 110 RF‐2009‐1511144 Pharmacological enhancement of tumor cell death by soluble or membrane TRAIL and SMAC‐mimetics 8,5 biomedica Oncology 2 ‐ Translational Clinical € 413.600,00 111 RF‐2009‐1511914 SEARCHING NEW THERAPEUTIC TARGETS IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) BY DISSECTING TUMOR CELL/ MICROENVIRONMENT INTERACTIONS 8,5 biomedica Oncology 1 ‐ Basic Translational € 465.000,00 112 RF‐2009‐1530968 Italian Network of Genetic Isolates (INGI): identification of genetic and environmental risk factors for cardiovascular disorders 8,5 biomedica Genes, Genomes and Genetics € 600.000,00 113 RF‐2009‐1527297 DRUG TRANSPORTERS AND RESISTANCE TO TREATMENT OF OVARIAN CARCINOMA 8,5 biomedica Oncology 1 ‐ Basic Translational 114 GR‐2009‐1579814 B cell reconstitution upon gene therapy in WAS patients from the first clinical trial with lentiviral vectors 8,5 biomedica Immunology € 580.000,00 115 RF‐2009‐1530786 Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches. 8,5 biomedica Oncology 1 ‐ Basic Translational € 264.000,00 € 463.100,00 Pagina 10 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 116 GR‐2009‐1594563 The Role of Endothelial Mineralocorticoid Receptors in Vascular Inflammation and Atherosclerosis 8,5 biomedica Vascular and Hematology € 501.215,00 117 GR‐2009‐1580434 MULTIDISCIPLINARY TRANSLATIONAL BIOMEDICS APPROACH TO BICUSPID AORTIC VALVE‐RELATED AORTOPATHY FOR THE DEVELOPMENT OF NEW CLINICAL DIAGNOSTIC AND PROGNOSTIC TOOLS 8,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 351.700,00 118 GR‐2009‐1493804 Theta‐band oscillations and resonance in the cerebellum: implications for cerebellar ataxia 8,5 biomedica Integrative, Functional, and Cognitive Neuroscience € 310.750,00 119 RF‐2009‐1475018 Studies on the functional role and regulation of a restricted signature of microRNAs in acute myeloid leukemia 8,5 biomedica Oncology 1 ‐ Basic Translational € 199.650,00 120 RF‐2009‐1469148 Growing Old with Less Disease Enhancing Neurofunctions (GOLDEN) study. A cohort study over young and old adults from general population 8,5 clinico assistenziale Biology of Development and Aging € 400.000,00 121 RF‐2009‐1504330 Development of novel drugs counteracting amyloid‐driven organ damage in systemic amyloidosis 8,5 biomedica Biological Chemistry and Macromolecular Biophysics € 597.300,00 122 RF‐2009‐1504327 Context‐specific response to proteotoxicity and its role in degenerative diseases 8,5 biomedica Cell Biology € 600.000,00 123 GR‐2009‐1471693 Tripartite‐Motif (TRIM) 22‐Mediated Restriction Of HIV‐1 And Other Pathogenic Human Retroviruses: Investigation Of The Molecular Interactions For Novel Therapeutic Approaches 8,5 biomedica AIDS and Related Research € 495.000,00 124 RF‐2009‐1491699 Cognitive reserve, brain reserve, and neuroplasticity in Alzheimer's disease 8,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 600.000,00 125 GR‐2009‐1473821 GENETIC AND FUNCTIONAL ANALYSIS OF COPY NUMBER VARIATIONS (CNVs) AFFECTING ION CHANNEL GENES IN FAMILIAL IDIOPATHIC GENERALIZED EPILEPSY 8,5 biomedica Genes, Genomes and Genetics € 354.500,00 126 RF‐2009‐1474050 Biomaterials to promote nerve regeneration: towards clinical trials. 8,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 450.000,00 Pagina 11 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 8,5 biomedica Molecular, Cellular, and Developmental Neuroscience Development of guidelines, management systems and new methodologies for GMOs traceability, own‐checks procedures and official control in the food and feed supply chain with respect to EU legal requirements 8,67 biomedica Veterinary ‐ Food Safety ‐ FOSA 129 RF‐2009‐1530936 Gene expression profiling in juvenile idiopathic arthritis: integrated analysis of clinical, imaging and molecular features 8,67 biomedica Musculoskeletal, Oral and Skin Sciences € 600.000,00 130 RF‐2009‐1532633 A renal transplant model designed to identify non‐invasive kidney injury biomarkers and urinary exosomes of acute rejection and nephrotoxicity. A study in a swine lymphocyte antigens (SLA)‐defined strain of pigs 8,75 biomedica Immunology € 565.380,00 131 GR‐2009‐1580433 Advanced diagnostics and innovative procedures for diagnosis and therapy in striated muscle channelopathies 8,75 biomedica Musculoskeletal, Oral and Skin Sciences € 420.860,00 132 RF‐2009‐1497629 Contribution of Urokinase Plasminogen Activator to HIV and Tumor Derived Stroma Driving Polarization of Macrophages 8,75 biomedica AIDS and Related Research € 460.000,00 133 GR‐2009‐1472102 Sudden cardiac death during myocardial ischemia: unmasking genetic factors contributing to ventricular fibrillation 8,75 biomedica Genes, Genomes and Genetics € 253.200,00 134 RF‐2009‐1505437 DEVELOPMENT OF BIOMARKERS BY LOW‐INVASIVE METHODS AND THEIR VALIDATION IN DUCHENNE MUSCULAR DYSTROPHY AND COLLAGEN 6 MYOPATHIES TO EVALUATE MECHANISM‐BASED PHARMACOLOGICAL THERAPY 8,84 biomedica Musculoskeletal, Oral and Skin Sciences € 330.000,00 135 RF‐2009‐1538005 Potentiating clinical and immunological effects of chemotherapy by neutralizing acidic pH at tumor site: a phase II randomized study in melanoma patients 8,84 clinico assistenziale Oncology 2 ‐ Translational Clinical € 429.550,00 136 RF‐2009‐1476258 STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTAL FACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROIDISM. NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISORDER 8,84 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 599.500,00 127 RF‐2009‐1473823 DEVELOPMENT OF DRUGS SELECTIVELY ACTIVATING Na+/Ca2+ EXCHANGER ISOFORMS TO TREAT CEREBRAL ISCHEMIA 128 RF‐2009‐1506132 € 429.000,00 € 594.185,00 Pagina 12 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 137 GR‐2009‐1596220 MECHANISMS AND EFFECTS OF THE DNA DAMAGE RESPONSE IN THE HEART AND NOVEL MOLECULAR APPROACHES TO ENHANCE CARDIOMYOCYTE REPAIR 9 biomedica Cardiovascular and Respiratory Sciences € 226.000,00 138 GR‐2009‐1574637 Elaboration and pre‐clinical validation of a combinatorial immunotherapeutic strategy for the dual targeting of tumour vessels and cancer initiating cells 9 biomedica Oncology 1 ‐ Basic Translational € 590.000,00 139 RF‐2009‐1525701 On demand‐release of antimicrobial agents on biofilm‐colonized urinary catheters by drug‐functionalized polymer nanoparticles and liposomes 9 biomedica Infectious Diseases and Microbiology € 600.000,00 140 GR‐2009‐1595946 Innovative screening tool for allergic diseases in children: impact on clinical outcome, quality of life and socio‐economic burden. 9 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 141 GR‐2009‐1604820 THE PREDICTOMIC STUDY: METABOLOMIC APPROACH IN PHENOTYPING AND DRUG RESPONSE PREDICTION IN PEDIATRIC RESPIRATORY DISESASES 9 biomedica Cardiovascular and Respiratory Sciences € 220.000,00 142 GR‐2009‐1606636 Mouse and human induced pluripotent stem cells for myocardial diseases. 9 biomedica Cardiovascular and Respiratory Sciences € 600.000,00 143 RF‐2009‐1511588 The role of B Cell Receptor stimulation in the pathogenesis of Chronic Lymphocytic Leukemia 9 biomedica Oncology 1 ‐ Basic Translational € 285.000,00 144 GR‐2009‐1594716 Mesenchymal Stem Cells and Inflammatory Bowel Disease 9 biomedica Digestive, Kidney and Urological Systems € 436.000,00 145 RF‐2009‐1546445 Role of natural killer cells in the pathogenesis and progression of multiple sclerosis 9 biomedica Immunology € 300.000,00 146 RF‐2009‐1549045 RIFF Project ‐ Risk and Incidence of Fragility Fractures (RIFF) in Italy for the updating and validation of the Italian version of FRAX® and supporting the Nation Registry of Fragility Fractures 9 clinico assistenziale Population Sciences and Epidemiology € 600.000,00 147 GR‐2009‐1566807 Reorganization of the macrophage epigenome during sustained inflammation and its functional implications. 9 biomedica Immunology € 558.300,00 148 GR‐2009‐1584108 "My Mind" Project: the effects of cognitive training for elderly 9 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 Pagina 13 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 149 RF‐2009‐1539999 Ultra‐deep pyrosequencing as a tool to evaluate the genetic variability of viruses, and to define markers of clinical relevance: from applied research to routine diagnosis 9 clinico assistenziale Infectious Diseases and Microbiology € 572.800,00 150 RF‐2009‐1533025 Role of kinases and phosphatases in controlling progression through mitosis 9 biomedica Cell Biology € 485.000,00 151 RF‐2009‐1544589 Endothelial injury and repair in diabetes. The development of a non‐invasive multimarker index for "vascular competence". 9 biomedica Vascular and Hematology € 430.000,00 152 GR‐2009‐1548255 Modulation of ER stress as a therapeutic approach in hereditary neuropathies 9 biomedica Molecular, Cellular, and Developmental Neuroscience € 600.000,00 153 GR‐2009‐1606827 Exploring the role of mitochondrial dynamics in the regulation of T cell homeostasis associated with MS 9 biomedica Cell Biology € 543.950,00 154 GR‐2009‐1584485 Role of kidney, breast and lung cancer stem cells in bone metastases 9 biomedica Oncology 1 ‐ Basic Translational € 188.000,00 155 RF‐2009‐1550345 MicroRNAs as molecular markers of susceptibility to Mycobacterium tuberculosis infection and responsiveness to vaccination in IRF‐8 deficient mouse model. 9 biomedica Infectious Diseases and Microbiology € 594.000,00 156 GR‐2009‐1583774 Regenerative potential of the proinflammatory cytokine interleukin 22: towards new therapeutic approaches for diabetic ulcer treatment 9 biomedica Musculoskeletal, Oral and Skin Sciences € 547.778,00 157 GR‐2009‐1580521 UNRAVELING THE PATHOGENESIS OF FAMILIAL MYELOPROLIFERATIVE NEOPLASMS: IDENTIFICATION OF THE INHERITED PREDISPOSITION THROUGH GENOME‐WIDE LINKAGE ANALYSIS, GENOME‐WIDE ASSOCIATION STUDIES AND NEXT GENERATION SEQUENCING 9 biomedica Vascular and Hematology € 342.000,00 158 GR‐2009‐1547415 Renal‐Committed Embryonic Stem Cells to Promote Kidney Regeneration 9 biomedica Digestive, Kidney and Urological Systems € 345.500,00 159 RF‐2009‐1547460 Poly(ADPribosyl)ation as a member of the regulators of mitochondrial function, implication in mitochondrial disorders 9 biomedica Brain Disorders and Clinical Neuroscience € 261.800,00 160 GR‐2009‐1608662 Therapeutic Inhibition of Classical and Lectin Pathways of Complement to Prevent Local and Systemic effects of Renal Ischemia Reperfusion Injury. 9 biomedica Digestive, Kidney and Urological Systems € 470.000,00 Pagina 14 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 161 GR‐2009‐1591481 Memory Enhancement by Advanced Non Invasive Brain Stimulation: A project on Neuro‐Rehabilitation of patients with memory diseases. 9 biomedica Brain Disorders and Clinical Neuroscience € 398.960,00 162 RF‐2009‐1549155 Proteomic analysis of newborn's saliva. 9 biomedica Biological Chemistry and Macromolecular Biophysics € 305.000,00 163 GR‐2009‐1578914 PATHOGENESIS OF COENZYME Q10 DEFICIENCY 9 biomedica Genes, Genomes and Genetics € 442.200,00 164 RF‐2009‐1483319 Validation of the micronucleus assay in buccal exfoliated cells as a tool for biomonitoring DNA damage in human populations and predicting cancer in healthy subjects. 9 biomedica Population Sciences and Epidemiology € 310.200,00 165 RF‐2009‐1472190 VRehab ‐Virtual Reality in the Assessment and TeleRehabilitation of Parkinsons Disease and Post‐Stroke Disabilities 9 clinico assistenziale Emerging Technologies and Training in Neurosciences € 584.500,00 166 GR‐2009‐1483560 iPS derived neural stem cells for Spinal Muscular Atrophy Therapy (SMAThera) 9 biomedica Brain Disorders and Clinical Neuroscience € 512.000,00 167 RF‐2009‐1470224 Functional relevance of Natural Killer cells in the pathogenesis of primary sclerosing cholangitis 9 biomedica Immunology 168 RF‐2009‐1505377 Converting the kinetochore‐spindle contact into an anticancer drug target 9 biomedica Cell Biology 169 RF‐2009‐1475846 Neuromodulation of synaptic plasticity in the cerebellum and its implications for cerebro‐cerebellar dysfunction in autism 9 biomedica Integrative, Functional, and Cognitive Neuroscience € 374.000,00 170 RF‐2009‐1475350 Cell‐permeable JNK3 inhibitor peptides as drug delivery system to prevent neurodegeneration in Alzheimer disease 9 biomedica Brain Disorders and Clinical Neuroscience € 450.000,00 171 GR‐2009‐1470633 Mucosal Dendritic Cells Anti‐inflammatory Phenotype Induction by Polyphenols Oral Administration: Effects on IBD Therapies. 9 biomedica Digestive, Kidney and Urological Systems € 495.000,00 172 GR‐2009‐1475467 Modulation of MicroRNA expression by microenvironmental stimuli in Chronic Lymphocytic Leukemia: implication for therapy 9 biomedica Oncology 1 ‐ Basic Translational € 491.000,00 € 439.000,00 € 521.100,00 Pagina 15 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 173 RF‐2009‐1473007 Optimization of ex‐vivo generation of human erythroid cells for transfusion 9 biomedica Vascular and Hematology € 422.305,30 174 RF‐2009‐1475532 Multimodality approach in epilepsy 9 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 280.000,00 175 RF‐2009‐1472009 Host cell interactions with replicating or non‐replicating Mycobacterium tuberculosis as a preclinical model to disclose new targets of immunointervention for tuberculosis 9 biomedica Cardiovascular and Respiratory Sciences € 500.000,00 176 RF‐2009‐1474839 Inflammation and neuroretinal injury in Diabetic Retinopathy: possible role of Pigment Epithelium Derived Factor as therapeutic agent 9 biomedica Cell Biology € 435.000,00 177 RF‐2009‐1536447 Coupling Soluble and Cellular Diagnostics with Advanced Therapeutics for Bone Metastasis 9,17 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 178 GR‐2009‐1580090 The role of leukaemia‐specific mutant of NPM1 in activation of Wnt signalling, retinoic acid sensitivity in NPMc+AML 9,25 biomedica Vascular and Hematology € 286.600,00 179 GR‐2009‐1591573 A new Cardiopulmonary By‐Pass system that minimizes haemodilution, haemolysis and systemic inflammation. Effects on organ damage and surgical outcome 9,25 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 280.000,00 180 RF‐2009‐1532096 GONARTHRITIS TREATMENT WITH PLATELET RICH PLASM (PRP): ANALYSIS OF JOINT MICROENVIRONMENT AND PRP GROWTH FACTORS TO PREDICT THE CLINICAL OUTCOME 9,25 biomedica Musculoskeletal, Oral and Skin Sciences € 247.000,00 181 RF‐2009‐1527300 Identification of immunosuppressive biomarkers in peripheral blood and tissues of patients with melanoma 9,25 biomedica Oncology 2 ‐ Translational Clinical € 598.000,00 182 GR‐2009‐1579266 Relationship between sleep‐disordered breathing and clinical phenotype in PD: paroxysmal motor‐behavioural manifestations, sleepiness and cognition. Uncover the effect by treating sleep apnoea. 9,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 106.500,00 183 GR‐2009‐1576377 Safety, traceability and reliability of collection, processing and transplantation of haematopoietic stem cells (HSCs) and therapeutic cells (TCs): integrated procedures and tools to support operations, clinical care and banking 9,25 clinico assistenziale Vascular and Hematology € 277.800,00 Pagina 16 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 184 GR‐2009‐1606803 CO‐TRANSPLANTATION OF MESENCHYMAL STEM CELLS AND PANCREATIC ISLETS: A PRECLINICAL STUDY TO EVALUATE THE EFFECT ON ENGRAFTMENT AND IMMUNORESPONSE AFTER CO‐LOCALIZATION IN THE BONE MARROW 9,25 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences 185 GR‐2009‐1574072 CLASSICAL AND INNOVATIVE STRATEGIES FOR THE IDENTIFICATION OF GENETIC DEFECTS AT THE BASIS OF RARE FORMS OF PARTIAL EPILEPSY 9,25 biomedica Genes, Genomes and Genetics € 312.000,00 186 GR‐2009‐1471033 Straight and curved walking in Parkinsons disease: basic mechanisms, pathophysiology and rehabilitation interventions 9,25 biomedica Musculoskeletal, Oral and Skin Sciences € 241.778,00 187 GR‐2009‐1596647 DEVELOPMENT OF NON‐INVASIVE STRATEGIES FOR PRENATAL DIAGNOSIS OF RARE DISEASES BASED ON SURFACE PLASMON RESONANCE (SPR)‐ IMAGING, PEPTIDE NUCLEIC ACIDS PROBES AND PCR‐FREE HYBRIDIZATION 9,5 biomedica Genes, Genomes and Genetics € 427.000,00 188 RF‐2009‐1521855 Novel mutated oncogenes in multiple myeloma 9,5 biomedica Oncology 1 ‐ Basic Translational € 550.000,00 189 GR‐2009‐1524351 Identification of functional role of potassium channels in primary aldosteronism 9,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 259.600,00 190 RF‐2009‐1524015 Endothelial cell‐cell junctions:targets for vascular normalization and therapeutic intervention in tumors 9,5 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 191 RF‐2009‐1536185 Food and environmental safety: the problem of the endocrine disruptors 9,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 192 GR‐2009‐1580131 Promoting and imaging restoration of brain function in Multiple Sclerosis 9,5 biomedica Brain Disorders and Clinical Neuroscience € 320.432,00 193 RF‐2009‐1538170 Functional analysis of NCAM in acute myeloid leukemia 9,5 biomedica Vascular and Hematology € 450.556,00 194 RF‐2009‐1539638 Role of the RNA‐binding protein Sam68 in the regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy 9,5 biomedica Genes, Genomes and Genetics € 360.000,00 195 GR‐2009‐1558698 Post‐translational modifications induced by reactive species in tumor microenvironment: a new pathway to tumor immune escape 9,5 biomedica Immunology € 500.000,00 € 500.000,00 Pagina 17 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 196 RF‐2009‐1511167 THE ROLE OF GENDER IN PARKINSON'S DISEASE: SEX‐SPECIFIC THERAPEUTIC APPROACH BASED ON NEUROACTIVE STEROIDS 9,5 biomedica Brain Disorders and Clinical Neuroscience € 341.000,00 197 RF‐2009‐1511590 Group I metabotropic glutamate receptors as possible targets for innovative pharmacological treatment of amyotrophic lateral sclerosis 9,5 biomedica Brain Disorders and Clinical Neuroscience € 599.860,00 198 RF‐2009‐1548345 Role of nutrients involved in one‐carbon metabolism in the development of different molecular subtypes of breast cancer in the ORDET cohort 9,5 clinico assistenziale Population Sciences and Epidemiology € 404.250,00 199 GR‐2009‐1594586 An open‐label, single‐ arm, phase II, prospective, pilot study of tocilizumab in patients with Erdheim‐Chester disease 9,5 clinico assistenziale Immunology € 430.000,00 200 RF‐2009‐1547785 Immunesurveillance of leukaemia by CD1‐restricted T cells specific for self‐lipid antigens 9,5 biomedica Immunology € 338.000,00 201 GR‐2009‐1594541 Exploiting oncogene addiction and premature senescence to design novel therapeutic strategies for the treatment of cancer 9,5 biomedica Cell Biology € 483.413,90 202 RF‐2009‐1547142 A novel endoscopic surveillance protocol in patients with Barretts esophagus to predict the progression to esophageal adenocarcinoma 9,5 biomedica Oncology 2 ‐ Translational Clinical € 480.000,00 203 RF‐2009‐1545765 Risk evaluation of human exposure to Mycobacterium avium subsp. paratuberculosis (Map) and comparative analysis of strains of human and animal origin 9,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 450.000,00 204 GR‐2009‐1607340 Improving dementia care using early counseling and support for caregivers. 9,5 clinico assistenziale Risk, Prevention and Health Behavior € 330.960,00 205 RF‐2009‐1546271 Cell therapy with different types of IL‐10‐producing regulatory T cells: pre‐clinical comparative validation of efficacy 9,5 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 206 RF‐2009‐1512226 Identification of new prognostic factors for disease outcome in a regional cohort of patients with B‐cell chronic lymphocytic leukemia (B‐CLL) 9,5 biomedica Vascular and Hematology € 300.000,00 207 RF‐2009‐1546282 Role of the regulatory pathways in the pathogenesis of T cell dysfunction in chronic HBV and HCV infections: diagnostic and therapeutic implications 9,5 biomedica Infectious Diseases and Microbiology € 600.000,00 Pagina 18 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 208 RF‐2009‐1530973 Rehabilitation of Acalculia 9,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 252.000,00 209 RF‐2009‐1475889 Physiopathology studies on the increased thyroid cancer incidence in the volcanic areas of Sicily 9,5 biomedica Oncology 1 ‐ Basic Translational € 589.050,00 210 RF‐2009‐1499162 Biomacromolecular characterization and multi‐resolution modeling in structural genomics/proteomics. Development of a comprehensive facility, and application to the fibrin(ogen)‐integrins cell‐extracellular matrix interactions model system. 9,5 biomedica Biological Chemistry and Macromolecular Biophysics € 447.778,00 211 RF‐2009‐1502259 Effects of Hp(2‐20) peptide on cutaneous, corneal, conjunctival and gastric wound healing 9,5 biomedica Veterinary ‐ Animal Health ‐ ANHE € 500.000,00 212 RF‐2009‐1476231 Protection against influenza infection: define persistence and cross‐reactivity of protective immune status induced by the natural infection and vaccination; analysis of the immunological milieu in human ex‐vivo models. 9,5 biomedica Infectious Diseases and Microbiology € 569.800,00 213 RF‐2009‐1473731 Development of a cerebellar connectivity EEG index to evaluate cerebro‐cerebellar interactions. 9,5 biomedica Brain Disorders and Clinical Neuroscience 214 RF‐2009‐1483387 TOTAL PANCREATECTOMY WITH ISLET AUTOTRANSPLANTATION AS A SUPERIOR ALTERNATIVE TO PANCREATODUODENECTOMY IN PATIENTS AT VERY HIGH‐RISK OF COMPLICATIONS OF THE PANCREATIC ANASTOMOSIS: A SINGLE‐CENTER PROSPECTIC RANDOMISED CLINICAL TRIAL 9,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 600.000,00 215 RF‐2009‐1473794 Role of the immune system in bone resorption: the mineralized matrix as an osteoclast‐activating danger signal 9,5 biomedica Musculoskeletal, Oral and Skin Sciences € 368.500,00 216 RF‐2009‐1471760 Understanding the interactions between retroviral vectors and the genome of human somatic stem cells 9,5 biomedica Genes, Genomes and Genetics € 470.000,00 217 RF‐2009‐1539625 Dynamic interplay between innate and acquired immune response and pandemic influenza A H1N1 2009 virus evolution 9,67 biomedica Infectious Diseases and Microbiology € 600.000,00 218 GR‐2009‐1555694 Towards an innovative therapy of Ectrodactyly‐Ectodermal dysplasia‐Clefting (EEC) syndrome using allele‐specific RNA silencing 9,67 biomedica Genes, Genomes and Genetics € 231.000,00 € 599.815,00 Pagina 19 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 219 GR‐2009‐1523273 New insights on the role of purinergic P2Y12 receptor in Multiple Sclerosis 9,75 biomedica Brain Disorders and Clinical Neuroscience € 367.500,00 220 RF‐2009‐1550154 Monitoring of chimerism on sorted peripheral CD34+ cells in patients with acute leukemia receiving allogeneic bone marrow transplantation 9,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 251.500,00 221 RF‐2009‐1536130 ASSESSING BEST STRATEGIES FOR ADAPTIVE IMAGE‐GUIDED TOMOTHERAPY 9,75 biomedica Oncology 2 ‐ Translational Clinical € 596.000,00 222 GR‐2009‐1592227 Adenoviral gene transfer of donor specific MHC class II on Aire expressing mTEC to induce allograft tolerance 9,75 biomedica Immunology € 275.500,00 223 GR‐2009‐1476067 Multi‐site RCT comparing regional and general anaesthesia for effects on neurodevelopmental outcome in infants ‐ The GAS study 9,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 250.000,00 224 GR‐2009‐1494693 Hunt for new disease genes in hereditary spastic paraplegia 9,75 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 225 GR‐2009‐1594665 A PROSPECTIVE COMPARATIVE STUDY BETWEEN OPEN AND ROBOTIC‐ ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY FOR PATIENTS WITH ORGAN‐CONFINED PROSTATE CANCER. IMPACT OF SURGICAL APPROACH ON ONCOLOGICAL AND FUNCTIONAL RESULTS , PERI‐OPERATIVE PARAMETERS AND COSTS. 9,84 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 240.000,00 226 GR‐2009‐1591574 Role of Chromatin Remodeling in Germ Stem Cell Identity 10 biomedica Genes, Genomes and Genetics € 500.000,00 227 GR‐2009‐1578364 A NEW MULTIDISCIPLINARY STRATEGY FOR DRUG DISCOVERY IN NEURODEGENERATIVE DISEASES 10 biomedica Molecular, Cellular, and Developmental Neuroscience € 590.100,00 228 GR‐2009‐1534956 Standardized Brain Imaging Database for the Evaluation of Semantic Memory Disorders and Cognitive Reserve in Mild Cognitive Impairment and Alzheimer's Disease (SBIDSMCR) 10 biomedica Brain Disorders and Clinical Neuroscience € 567.000,00 229 GR‐2009‐1601048 Psychological consequences of cancer in elderly patients and their family 10 clinico assistenziale Oncology 2 ‐ Translational Clinical € 387.660,00 Pagina 20 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 230 GR‐2009‐1592249 Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replication stress response and its potential for early diagnosis and target therapy of cancer 10 biomedica Oncology 1 ‐ Basic Translational € 561.000,00 231 RF‐2009‐1548415 Preclinical characterization and sequence optimization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis 10 biomedica Infectious Diseases and Microbiology € 376.200,00 232 RF‐2009‐1547600 Role of HIV‐1 infection on colorectal carcinoma onset and progression and development of novel therapeutic strategies 10 biomedica AIDS and Related Research € 533.500,00 233 GR‐2009‐1578335 The molecular signature of liver autoimmunity: genome‐wide differences in epigenetics and copy number variations between monozygotic twins discordant for primary biliary cirrhosis 10 biomedica Digestive, Kidney and Urological Systems € 423.000,00 234 GR‐2009‐1592265 Mechanism‐driven exploration of hormonal interventions for menopause‐ and aging‐related cardiovascular diseases 10 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 495.000,00 235 RF‐2009‐1532731 "Tailored" Accreditation Model for Comprehensive Cancer Centers: validation through the applicability of the experimental OECI‐based model to the Network of Cancer IRCCS of Alleanza contro il Cancro 10 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 236 GR‐2009‐1594650 Service for detection of Pre‐psychosES: from genomics to phenomenology in a human/animal perspective 10 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 237 RF‐2009‐1532789 IGF‐I isoforms and Breast Cancer 10 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 444.400,00 238 GR‐2009‐1580427 Evaluation of cytochrome p450 2D6 and 2C19, ABCG1, ABCG2 polymorphisms in patients affected by chronic myeloid leukemia and their therapeutic implications 10 clinico assistenziale Oncology 2 ‐ Translational Clinical € 189.000,00 239 GR‐2009‐1536300 Role of Che‐1 in DNA damage response 10 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 240 GR‐2009‐1607203 Identification of immunological molecular patterns in atherosclerosis. 10 biomedica Vascular and Hematology € 518.500,00 Pagina 21 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 241 RF‐2009‐1546106 ANTIPLATELET TREATMENT FOR PREVENTION OF VASCULAR OUTCOMES IN PAD PATIENTS UNDERGOING PERIPHERAL REVASCULARIZATION. 10 clinico assistenziale Vascular and Hematology € 328.500,00 242 GR‐2009‐1607176 Investigation of novel indicators of sleepiness in healthy subjects and in sleep disorders by simultaneous polysomnographic‐fMRI techniques 10 biomedica Emerging Technologies and Training in Neurosciences € 598.600,00 243 GR‐2009‐1560224 Development of a multifunction platform for telerehabilitation. 10 biomedica Healthcare Delivery and Methodologies € 367.000,00 244 RF‐2009‐1538597 Study of the healthy benefits of anthocyanin dietary supplementation on obesity and cancer 10 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 483.333,00 245 RF‐2009‐1530649 Development of a novel mouse model of B‐CLL: validation of p66Shc as a prognostic marker and therapeutic target 10 biomedica Oncology 2 ‐ Translational Clinical € 500.000,00 246 GR‐2009‐1568943 Management of severe health care associated infections in high‐risk departments based on on‐line Infectious Diseases Specialists consulting: evaluation of efficacy and efficiency 10 clinico assistenziale Healthcare Delivery and Methodologies € 238.850,00 247 GR‐2009‐1608068 The non‐oncotic properties of human serum albumin in liver cirrhosis: functional characterization, clinical application and therapeutic perspectives. 10 biomedica Digestive, Kidney and Urological Systems € 550.000,00 248 RF‐2009‐1521760 Role of IL‐2 family cytokines in the regulation of cell survival and gene expression of neoplastic B cells 10 biomedica Vascular and Hematology € 350.000,00 249 GR‐2009‐1606542 The role of Gas6/RTK receptors in Rheumatoid Arthritis and Multiple Sclerosis: a patient and biological study 10 biomedica Immunology € 240.000,00 250 RF‐2009‐1470059 Identification of a Polycystin‐1/Nephrocystin‐1 Complex: functional and biochemical studies in vitro and in vivo 10 biomedica Digestive, Kidney and Urological Systems € 600.000,00 251 RF‐2009‐1472847 Identification of new biomarkers for metabolic syndrome associated with antipsychotic treatment 10 biomedica Biobehavioral and Behavioral Processes € 600.000,00 252 RF‐2009‐1473897 From BioEngineering new tools for identification of early markers of respiratory and cardiac impairment in Duchenne Muscular Dystrophy 10 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 290.000,00 Pagina 22 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 253 RF‐2009‐1475209 Exome sequencing of familial Parkinson disease: fishing for new genes trough next generation sequencing 10 biomedica Genes, Genomes and Genetics € 600.000,00 254 RF‐2009‐1474229 MOLECULAR AND PHARMACOLOGICAL CHARACTERIZATION OF TMEM16A (ANOCTAMIN 1) AS A NOVEL CHLORIDE CHANNEL 10 biomedica Cell Biology € 369.565,00 255 RF‐2009‐1472407 The mevalonate pathway as a target of immune intervention in lymphoproliferative diseases and solid cancers 10 biomedica Oncology 2 ‐ Translational Clinical € 150.000,00 256 GR‐2009‐1471382 From hyperphenylalaninemia to mental retardation: the key role of serotonin. 10 biomedica Brain Disorders and Clinical Neuroscience € 579.150,00 257 GR‐2009‐1469881 Proteins and genes in Frontotemporal lobar degeneration: old and novel players in neurodegeneration 10 biomedica Genes, Genomes and Genetics € 584.100,00 258 RF‐2009‐1492565 A multidisciplinary approach to unravel the role of uromodulin in chronic diseases of the kidney 10 biomedica Digestive, Kidney and Urological Systems € 600.000,00 259 RF‐2009‐1493248 MECHANISMS OF HCV PERSISTENCE IN THE HOST AND INDUCTION OF THE LYMPHOMAGENETIC PROCESS 10 biomedica Oncology 1 ‐ Basic Translational € 235.000,00 260 GR‐2009‐1493080 GENERATION AND TRANSPLANTATION OF GENETICALLY ENGINEERED NEURAL STEM CELLS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 10 biomedica Brain Disorders and Clinical Neuroscience € 535.095,00 261 RF‐2009‐1491217 Integrated approaches for the classification of variants of uncertain significance in BRCA genes. 10 biomedica Oncology 1 ‐ Basic Translational € 280.500,00 262 RF‐2009‐1485550 Combating Mitochondrial Disorders in cells, animal models and patients 10 biomedica Molecular, Cellular, and Developmental Neuroscience € 597.300,00 263 RF‐2009‐1499021 A metagenomic approach to evaluate the influence of antimicrobial therapy on the selection of multi‐drug resistant clones responsible for health‐care‐associated infections in the Intensive Care Unit setting 10 biomedica Infectious Diseases and Microbiology € 580.000,00 264 RF‐2009‐1468351 The role of necdin in the self renewal and activation of endogenous stem cells for the repair of dystrophic muscle 10 biomedica Musculoskeletal, Oral and Skin Sciences € 300.000,00 Pagina 23 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 265 RF‐2009‐1498662 Identification of self‐renewal programs in epidermal stem cells. 10 biomedica Musculoskeletal, Oral and Skin Sciences € 368.000,00 266 GR‐2009‐1476273 Understanding the formation of hyperplastic lesions in human proliferative glomerulonephritis: role of endothelin in promoting podocyte migration 10 biomedica Digestive, Kidney and Urological Systems € 590.000,00 267 RF‐2009‐1505025 Characteristics of persons with HIV/AIDS in Italy: a cross‐sectional study 10 clinico assistenziale AIDS and Related Research € 510.000,00 268 RF‐2009‐1483297 Pathological relevance of B‐cell abnormalities and Epstein‐Barr virus infection in multiple sclerosis: focus on early brain lesions and cases with relapsing remitting and aggressive disease. 10 biomedica Brain Disorders and Clinical Neuroscience € 301.400,00 269 RF‐2009‐1494489 Ovarian stimulation for infertility treatment and cancer risk: an italian cohort study 10 clinico assistenziale Population Sciences and Epidemiology € 300.100,00 270 RF‐2009‐1474965 Role and mechanisms of the homeprotein Prep1 in pathogenesis and diagnosis of human type II diabetes and obesity. 10,17 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 600.000,00 271 GR‐2009‐1606283 RECESSIVE SPINOCEREBELLAR ATAXIAS: AN INTEGRATED CLINICAL, NEURORADIOLOGICAL, BIOCHEMICAL AND GENETIC APPROACH FOR THE IDENTIFICATION OF NEW PHENOTYPES AND POSSIBLE BIOMARKERS 10,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 162.000,00 272 GR‐2009‐1583925 Immunological biomarkers predictive of successful antiviral therapy in chronic HCV infection 10,25 biomedica Immunology € 600.000,00 273 GR‐2009‐1591005 Integration of deep and low coverage sequencing data in a genome‐wide association study for HbF levels and its implication in the clinical severity of beta‐ thalassemia. 10,25 biomedica Genes, Genomes and Genetics € 600.000,00 274 GR‐2009‐1576636 THERAPEUTIC APPROACHES IN FABRY DISEASE AND GM1 GANGLIOSIDOSIS CAUSED BY RNA AND CONFORMATIONAL DEFECTS 10,25 biomedica Biobehavioral and Behavioral Processes € 217.000,00 275 GR‐2009‐1543842 Optimization of selection criteria for patients affected by metastatic HER2 overexpressing breast cancers eligible for a frontline treatment with Trastuzumab or Lapatinib 10,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 426.000,00 Pagina 24 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 276 GR‐2009‐1580035 Orienting of spatial attention in complex environments: intra‐regional activation and inter‐regional connectivity in the intact and the damaged human brain 10,25 biomedica Brain Disorders and Clinical Neuroscience € 447.700,00 277 GR‐2009‐1607901 Molecular and functional characterization of a cell adhesion molecule in a novel ectodermal dysplasia syndrome and in cancer 10,25 biomedica Genes, Genomes and Genetics € 367.000,00 278 GR‐2009‐1574241 Preoperative TPF chemotherapy in locally advanced resectable oral cavity squamous cell cancer in order to improve pathological complete response rate: a phase II study 10,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 310.750,00 279 RF‐2009‐1474128 ADVANCED PRODUCTS AND PROTOCOLS FOR THE PREVENTION AND TREATMENT OF DIABETIC FOOT ULCERS 10,25 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 600.000,00 280 RF‐2009‐1491712 WNT signaling and clock genes in the pathogenesis of Bipolar Disorder 10,25 biomedica Brain Disorders and Clinical Neuroscience € 530.000,00 281 RF‐2009‐1524129 The role of the extracellular matrix protein EMILIN1 in tumor growth and lymphatic spread 10,34 biomedica Oncology 1 ‐ Basic Translational € 239.000,00 282 RF‐2009‐1476141 Can a heart failure specific cardiac rehabilitation program decrease hospitalizations and improve outcomes in patients with chronic advanced heart failure? 10,34 clinico assistenziale Healthcare Delivery and Methodologies € 350.000,00 283 RF‐2009‐1499059 THE ROLE OF ADIPOKINES OF THE CTRP FAMILY IN CAUSING ARTERIAL HYPERTENSION AND PREMATURE PATHOLOGY OF THE CEREBROVASCULAR SYSTEM 10,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 462.000,00 284 GR‐2009‐1594720 Transposon‐based genetic screening for non‐coding RNAs involved in colorectal cancer metastasis 10,5 biomedica Genes, Genomes and Genetics 285 RF‐2009‐1524178 Reducing unjustified consumer alarmism by mapping, monitoring and improving food safety communication in the media 10,5 clinico assistenziale Veterinary ‐ Food Safety ‐ FOSA € 450.400,00 286 GR‐2009‐1606728 Molecular characterization of glioblastoma stem cell contribution to tumor angiogenesis to design novel therapies for glioblastoma treatment 10,5 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 € 386.100,00 Pagina 25 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 287 GR‐2009‐1568054 Inflammation and immune responses in vitamin D deficient patients. 10,5 biomedica Musculoskeletal, Oral and Skin Sciences € 482.000,00 288 RF‐2009‐1544535 Cancer survivorship: A new paradigm of care 10,5 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 289 RF‐2009‐1511541 Vertical viral transmission as a frequent cause of autism 10,5 biomedica Brain Disorders and Clinical Neuroscience € 489.500,00 290 RF‐2009‐1544568 IMPLEMENTATION OF INTERPERSONAL PSYCHOTHERAPY IN A COLLABORATIVE STEPPED CARE MODEL 10,5 clinico assistenziale Healthcare Delivery and Methodologies € 100.000,00 291 RF‐2009‐1549630 Biological Characterization, Molecular Diagnosis and Targeted Circumvention of Leukemia Immunoediting after Hematopoietic Stem Cell Transplantation 10,5 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 292 GR‐2009‐1594575 Involvement of dysregulated OPG/RANK/RANKL axis in atherogenesis and acute coronary syndromes 10,5 biomedica Vascular and Hematology € 475.000,00 293 RF‐2009‐1538536 The RNA Interactome of TLS/FUS as a novel approach to understand RNA dys‐ metabolism in ALS 10,5 biomedica Brain Disorders and Clinical Neuroscience € 228.000,00 294 GR‐2009‐1603038 Impact of TACE/Timp3 dyad in neurovascular disorders: a proteomic investigation 10,5 biomedica Biological Chemistry and Macromolecular Biophysics € 600.000,00 295 GR‐2009‐1505647 Treatment of Neurological Impairment in Lysosomal Storage Diseases by the Use of Neural Stem Cells 10,5 biomedica Brain Disorders and Clinical Neuroscience € 594.770,00 296 GR‐2009‐1573993 Dissecting the role of plasmacytoid dendritic cells in cancer. 10,5 biomedica Immunology € 600.000,00 297 RF‐2009‐1549386 Non‐invasive biomarkers of diagnosis, recurrence and tumor response in colon and rectal cancer 10,5 biomedica Oncology 2 ‐ Translational Clinical € 584.100,00 298 RF‐2009‐1527182 Adult human stem cells as a source for kidney and liver regeneration 10,5 biomedica Digestive, Kidney and Urological Systems € 300.000,00 299 GR‐2009‐1607990 The extracellular matrix protein EMILIN1 as a determinant in the pathogenesis of lymphedema: a basis for new therapeutic approaches 10,5 biomedica Vascular and Hematology € 298.700,00 Pagina 26 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 300 GR‐2009‐1528084 Hom Sweet Hom: Identification and control of the determinants of the homoplasmic shift of mitochondrial DNA mutations to drive benign tumorigenesis 10,5 biomedica Oncology 1 ‐ Basic Translational € 444.500,00 301 RF‐2009‐1548366 Influence of Telomere Length on the Risk of Ischemic Stroke and Prediction of Poststroke Recurrence 10,5 biomedica Brain Disorders and Clinical Neuroscience € 408.000,00 302 GR‐2009‐1526346 Clinical data‐driven research of new stem cell‐modulating agents for vascular repair in diabetes 10,5 biomedica Cardiovascular and Respiratory Sciences € 250.000,00 303 RF‐2009‐1532533 The mother in the cord: the immune privilege translated to the stem cells transplant setting 10,5 biomedica Immunology € 510.000,00 304 RF‐2009‐1474941 Characterization of the role of Polycomb post‐translational modifications and of the recruiting factor Jarid2 in differentiation and cancer. 10,5 biomedica Genes, Genomes and Genetics € 595.000,00 305 GR‐2009‐1498737 LYMPHOCYTE ACTIVATION AND HOMING DEFECTS IN THE WHIM SYNDROME 10,5 biomedica Immunology € 495.600,00 306 RF‐2009‐1475919 Set up of new procedures for selective allo‐depletion preserving regulatory T cells: a comprehensive approach to prevent both Graft Versus Host Disease and Severe infections in Hematopoietic Stem Cells Transplantation. 10,5 biomedica Immunology € 230.000,00 307 RF‐2009‐1494405 A translational approach to restrain recurrence of early breast cancer 10,5 biomedica Oncology 1 ‐ Basic Translational € 322.200,00 308 RF‐2009‐1474386 G15 Protein as a Therapeutic Target in Pancreas Cancer 10,5 biomedica Cell Biology € 245.500,00 309 RF‐2009‐1485135 Mapping the epigenome of tumor cells: identifying causes, markers and targets for new epigenetic therapies 10,5 biomedica Oncology 1 ‐ Basic Translational € 376.100,00 310 RF‐2009‐1468136 Induced pluripotent stem cells as a potential source of autologous neural stem cells for multiple sclerosis therapy 10,5 biomedica Brain Disorders and Clinical Neuroscience € 580.000,00 311 RF‐2009‐1494829 Role of microRNA‐221 and microRNA‐222 in the pathogenesis of muscular dystrophies 10,5 biomedica Musculoskeletal, Oral and Skin Sciences € 412.200,00 Pagina 27 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 312 RF‐2009‐1491506 An integrated platform for molecular and cellular studies in chronic myeloproliferative neoplasms to identify novel biomarkers and targets for therapy 10,5 biomedica Oncology 1 ‐ Basic Translational € 294.000,00 313 RF‐2009‐1491197 A PROSPECTIVE STUDY TO EVALUATE THE INFLUENCE OF GENETIC VARIATION OF THE ORGANIC CATION AND MULTIDRUG AND TOXIN EXTRUSION TRANSPORTERS ON THE RESPONSE TO METFORMIN IN DRUG‐ NAÏVE TYPE 2 DIABETIC PATIENTS 10,5 biomedica Genes, Genomes and Genetics € 353.000,00 314 GR‐2009‐1492080 Adenosine A2A receptors as potential therapeutic targets in Niemann‐Pick type C disease 10,5 biomedica Brain Disorders and Clinical Neuroscience € 430.000,00 315 RF‐2009‐1486727 Role of functional polymorphisms of the brain serotonin synthesizing enzyme TPH2 in treatment‐resistant depression: from human single gene mutations to mouse models. 10,5 biomedica Brain Disorders and Clinical Neuroscience € 591.111,00 316 RF‐2009‐1472856 High‐throughput copy number variation discovery in oculo‐auriculo‐vertebral spectrum: identification of disease‐causing genes and loci and implications in clinical diagnostics 10,5 biomedica Genes, Genomes and Genetics € 334.600,00 317 GR‐2009‐1475631 Novel drugs for targeted anticancer therapy 10,5 biomedica Oncology 1 ‐ Basic Translational € 321.600,00 318 RF‐2009‐1475880 Aberrant gene expression and facioscapulohumeral muscular dystrophy (FSHD): role of non‐protein coding RNAs and the epigenome. 10,5 biomedica Genes, Genomes and Genetics € 600.000,00 319 RF‐2009‐1511116 Natural Control of HIV‐1 Infection in the Absence of Antiretroviral Therapy. A Prospective Multi‐cohort Study of HIV‐1+ Long‐Term Nonprogressors (LTNP) and Viral Controllers. 10,67 biomedica AIDS and Related Research € 600.000,00 320 RF‐2009‐1486196 Evaluation of anthocyanin mechanisms of action in diabetes: effects on endothelial dysfunction and on cardiovascular markers in human 10,67 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 292.489,00 321 RF‐2009‐1511499 Use of saliva as biological matrix for non invasive screening of oral cancer ‐ ONCOSAL (ONCOlogical Diagnosis by SALiva) 10,75 biomedica Oncology 2 ‐ Translational Clinical € 560.000,00 322 GR‐2009‐1606641 Oxidative Stress in Multiple Sclerosis disease progression. A proteomic and red‐ ox proteomic analysis 10,75 biomedica Brain Disorders and Clinical Neuroscience € 540.000,00 Pagina 28 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 323 RF‐2009‐1551299 Biomarkers for objective assessment and early detection of work‐related upper extremity musculoskeletal disorders (WRUEMSDs) 10,75 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 408.000,00 324 RF‐2009‐1511573 Untargeted approach in detecting food adulteration and contamination using spectroscopic techniques database and chemometrics 10,75 biomedica Veterinary ‐ Food Safety ‐ FOSA € 500.000,00 325 RF‐2009‐1547447 Origin and evolution of recent vector‐borne virus incursions in the Mediterranean Basin 10,75 biomedica Veterinary ‐ Animal Health ‐ ANHE € 503.250,00 326 GR‐2009‐1595395 THE RELATIONSHIP BETWEEN BORDERLINE PERSONALITY DISORDER AND BIPOLAR DISORDER: A CLINICAL, MORPHOLOGIAL CEREBRAL AND BIOLOGICAL COMPARISON STUDY 10,75 biomedica Brain Disorders and Clinical Neuroscience € 505.000,00 327 RF‐2009‐1538720 Pulmonary Rehabilitation and Inflammation Status in COPD 10,75 clinico assistenziale Cardiovascular and Respiratory Sciences € 271.357,00 328 GR‐2009‐1594885 ARTT: Androgen receptors as targets for the treatment of estrogen and progestin receptor positive and negative breast cancers 10,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 225.000,00 329 RF‐2009‐1545455 Integrated program of experimental and clinical research to improve the outcome of lung transplantation 10,75 biomedica Cardiovascular and Respiratory Sciences € 395.000,00 330 GR‐2009‐1607350 Administration of Protein C concentrates in patients with severe sepsis and contraindication to activated protein C. A multicentre randomized placebo‐ controlled study. 10,75 clinico assistenziale Infectious Diseases and Microbiology € 600.000,00 331 RF‐2009‐1473679 Expanding the donor pool through the therapeutic applications of carbon monoxide (CO) and biliverdin in transplantation. Evaluation of efficacy in an in vivo porcine model and feasibility of a clinical trial in the donor 10,75 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 466.000,00 332 RF‐2009‐1499038 TRANSLATIONAL APPLICATIONS ENSUING CIRCULATING IMMUNOCOMPLEXES STUDY IN GASTRIC CARCINOMA AND LYMPHOMA‐ FROM IDENTIFICATION OF BIOMARKERS TO PRODUCTION OF POTENTIAL THERAPEUTIC COMPOUNDS 10,75 biomedica Biological Chemistry and Macromolecular Biophysics € 330.000,00 333 RF‐2009‐1498724 Generation of artificial lymphoid organs to enhance anti‐tumor immunity. 10,75 biomedica Immunology € 350.000,00 Pagina 29 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 334 RF‐2009‐1492626 Characterisation of the Envelope protein sequence of HIV‐1 subtype C variants and evaluation of their sensitivity/resistance to neutralisation by sera from HIV‐ infected individuals: an approach for the development of novel immunogens for a vaccine against 10,75 biomedica AIDS and Related Research € 588.500,00 335 RF‐2009‐1493881 Prevention of work injuries Evaluating the effectiveness of safety interventions carried out by Occupational Health Services of Local Health Authorities in the whole Veneto region (Northeastern Italy) from 2001 to 2007. 10,75 clinico assistenziale Healthcare Delivery and Methodologies € 150.000,00 336 RF‐2009‐1501148 Immuno‐phenotypic and microRNA profiles in breast cancer and adjacent non‐ involved tissues as biomarkers of tumor progression 10,75 biomedica Oncology 2 ‐ Translational Clinical € 363.000,00 337 RF‐2009‐1530324 A multi‐center phase II randomized study of CustOmized Neoadjuvant ThErapy vs Standard chemoTherapy in non‐small cell lung cancer (NSCLC) patients with resectable stage IIIA(N2) disease (CONTEST trial) 10,84 clinico assistenziale Oncology 2 ‐ Translational Clinical € 274.057,00 338 RF‐2009‐1545404 Dialogue between "tissue signaling lymphocytes" and keratinocytes in the expression and persistence of psoriatic phenotype: identification of molecular pathways for innovative biologic therapy 10,84 biomedica Immunology € 410.000,00 339 GR‐2009‐1606348 TIA pathway implementation to improve clinical management in a second level hospital 10,84 clinico assistenziale Brain Disorders and Clinical Neuroscience € 348.000,00 340 RF‐2009‐1550148 Teleradiology program for frail patients living at home or in nursing‐homes 10,88 clinico assistenziale Healthcare Delivery and Methodologies € 209.000,00 341 GR‐2009‐1605076 Autoimmunity associated with primary immunodeficiency due to partial V(D)J recombination defects: mechanisms and novel therapeutic approaches 11 biomedica Immunology € 300.000,00 342 RF‐2009‐1544566 Impact of HCV natural variants on new anti‐viral drugs: implementation of a national sequence database of HCV viruses circulating in Italy 11 biomedica Infectious Diseases and Microbiology € 400.000,00 343 GR‐2009‐1605762 Study of effects of rapamycin treatment on cortical neurons of a mouse model of Amyotrophic Lateral Sclerosis 11 biomedica Molecular, Cellular, and Developmental Neuroscience € 340.000,00 Pagina 30 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 344 RF‐2009‐1511075 Prognostic role of neurophysiological monitoring (continuous video‐EEG, somatosensory and auditory evoked potentials) in neonatal hypoxic‐ischemic encephalopathy managed with hypothermia 11 clinico assistenziale Brain Disorders and Clinical Neuroscience € 200.000,00 345 GR‐2009‐1591378 Effect of SMS based life style intervention in subjects with obesity or moderate cardiovascular risk 11 biomedica Population Sciences and Epidemiology € 597.300,00 346 RF‐2009‐1512087 Pathway Dissection In Leukocyte Extravasation: Identification And Validation Of Novel Therapeutic Targets In Nonresolving Inflammatory Processes 11 biomedica Immunology € 600.000,00 347 GR‐2009‐1553637 Relationship between DNA damage and signaling revealed in mouse models of Ataxia Telangiectasia 11 biomedica Oncology 1 ‐ Basic Translational € 394.900,00 348 GR‐2009‐1605521 The use of a biodrug, CTLA4‐Ig, in the immunometabolic control of experimental multiple sclerosis 11 biomedica Immunology € 381.000,00 349 GR‐2009‐1553664 A PROSPECTIVE STUDY TO EVALUATE THE RELATIONSHIP BETWEEN HISTOLOGICAL FEATURES AND VASCULAR RESISTANCES ASSESSED BY MACHINE PERFUSION IN KIDNEYS FROM OLDER DONORS AND THE PREDICTIVE VALUE OF THESE TWO PARAMETERS ON GRAFT OUTCOMES 11 clinico assistenziale Digestive, Kidney and Urological Systems € 184.000,00 350 GR‐2009‐1569626 MECHANISMS OF RESISTANCE TO CHEMOTERAPEUTIC AND ANTI‐ ANGIOGENIC DRUGS AS NOVEL TARGETS FOR PANCREATIC CANCER THERAPY 11 biomedica Oncology 1 ‐ Basic Translational € 427.380,00 351 GR‐2009‐1575236 PRECLINICAL DETECTION OF ALZHEIMER'S DISEASE BY ADVANCED MRI TECHNIQUES: FUNCTIONAL MRI AND DIFFUSION TENSOR IMAGING 11 clinico assistenziale Brain Disorders and Clinical Neuroscience € 281.000,00 352 RF‐2009‐1550130 NOVEL AND SELECTIVE ANTI‐TUMOR STRATEGIES FOR THE TREATMENT OF GLIOMA 11 biomedica Brain Disorders and Clinical Neuroscience € 265.680,00 353 GR‐2009‐1575091 Detection and characterization of new caliciviruses in swine and development of novel diagnostic tools to assess their circulation in humans 11 biomedica Veterinary ‐ Animal Health ‐ ANHE € 195.000,00 354 RF‐2009‐1506148 Diet‐induced changes in visceral fat‐associated inflammation and colon cancer 11 biomedica Immunology € 546.700,00 355 GR‐2009‐1555876 A PRECLINICAL PLATFORM TO STUDY THE PATHOGENESIS OF STROKE‐ RELATED FOCAL EPILEPSY 11 biomedica Brain Disorders and Clinical Neuroscience € 497.860,00 Pagina 31 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 356 RF‐2009‐1538659 Genetic and genomic approaches for the study of sporadic ALS: new animal models 11 biomedica Molecular, Cellular, and Developmental Neuroscience € 405.000,00 357 GR‐2009‐1580566 Role of mitochondrial S‐adenosylmethionine transporter in mitochondrial methylation and metabolism: a new potential target for the study of the maternally inherited deafness 11 biomedica Genes, Genomes and Genetics € 334.000,00 358 RF‐2009‐1527193 PEPTIDE RECEPTOR RADIONUCLIDE THERAPY WITH 177Lu‐DOTATATE ASSOCIATED WITH METRONOMIC CAPECITABINE IN PATIENTS AFFECTED BY AGGRESSIVE GASTRO‐ENTERO‐PANCREATIC NEUROENDOCRINE TUMORS 11 clinico assistenziale Oncology 2 ‐ Translational Clinical € 590.000,00 359 RF‐2009‐1536388 Analysis of in vivo and in vitro immunogenicity of putative GPI‐anchored proteins of Babesia for vaccine and diagnostic purposes 11 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 360 RF‐2009‐1549380 A prospective study on the role played by maternal prenatal stress, in interaction with mother‐infant relationship and genetics, on later infant bio‐behavioural development. 11 biomedica Biobehavioral and Behavioral Processes € 398.000,00 361 RF‐2009‐1526992 Genomic function of the c‐Myc oncoprotein 11 biomedica Genes, Genomes and Genetics € 595.000,00 362 RF‐2009‐1546695 New approaches to early diagnosis of breast cancer based on identification of metabolites in cancer patient breath and biological fluids as candidate biomarkers 11 biomedica Oncology 2 ‐ Translational Clinical € 335.500,00 363 RF‐2009‐1539308 Prognosis and therapy of melanoma: the potential role of microRNAs 11 biomedica Oncology 2 ‐ Translational Clinical € 572.000,00 364 GR‐2009‐1531001 New strategy for the treatment of schizophrenia and other neurodegenerative diseases: inhibition and allosteric regulation of serine racemase 11 biomedica Biological Chemistry and Macromolecular Biophysics € 425.000,00 365 GR‐2009‐1605011 Malformations of cortical development: diagnostic algorithm and straightforward tools to identify and characterize novel disease genes 11 biomedica Genes, Genomes and Genetics € 245.000,00 366 RF‐2009‐1529288 Innovative approach for the in vivo detection and treatment of Multiple Myeloma 11 biomedica Oncology 2 ‐ Translational Clinical € 500.000,00 Pagina 32 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 367 RF‐2009‐1536129 Health Technology Assessment (HTA) of HIV rapid testing policy in Italy 11 clinico assistenziale AIDS and Related Research 368 GR‐2009‐1607204 Development of new highly selective anti‐LOX‐1 receptor molecules to use for the prevention and therapy of reperfusion injury in acute myocardial infarction 11 biomedica Cardiovascular and Respiratory Sciences € 600.000,00 369 RF‐2009‐1545238 Diffusion of HPV infection and clinical correlates in males 11 biomedica Infectious Diseases and Microbiology € 600.000,00 370 RF‐2009‐1511638 Purinergic P2X7 Receptor in Amyotrophic Lateral Sclerosis 11 biomedica Brain Disorders and Clinical Neuroscience € 277.200,00 371 GR‐2009‐1607249 Identification of novel genetic biomarkers of response to treatment in Multiple Sclerosis: a genome‐wide approach 11 biomedica Genes, Genomes and Genetics € 600.000,00 372 GR‐2009‐1607012 Natural history, genetics and immunopathogenesis of potential celiac disease. 11 biomedica Digestive, Kidney and Urological Systems € 450.000,00 373 RF‐2009‐1519566 The impact and biology of HIV‐associated neurocognitive disorders (HAND) in treated patients with HIV infection achieving systemic virological suppression 11 biomedica AIDS and Related Research € 492.000,00 374 RF‐2009‐1511459 EMERGENCY GERIATRIC EVALUATION UNIT: A MODEL TO IMPROVE EFFECTIVENESS AND QUALITY OF THE MANAGEMENT AND CARE OF THE ELDERLY IN THE EMERGENCY ROOM 11 clinico assistenziale Healthcare Delivery and Methodologies € 240.000,00 375 GR‐2009‐1473148 Culture and characterisation of oral mucosal and conjunctival epithelial stem cells for the reconstruction of the ocular surface in patients with bilateral limbal stem cell deficiency 11 biomedica Brain Disorders and Clinical Neuroscience € 599.500,00 376 RF‐2009‐1472439 Study of the role of Toll‐like receptors in leukemogenesis 11 biomedica Oncology 1 ‐ Basic Translational € 165.000,00 377 RF‐2009‐1476009 New therapeutical approach for osteoarthritis: in vitro and in vivo evidences of bone‐marrow cell transplantation 11 biomedica Musculoskeletal, Oral and Skin Sciences € 597.300,00 378 RF‐2009‐1472891 Pathogenesis of Major Psychoses and Dementias: hypothesized points of convergence 11 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 € 215.000,00 Pagina 33 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 379 RF‐2009‐1500726 Cell therapy for treatment of restenosis: a preclinical study in rat and pig animal models 11 biomedica Vascular and Hematology € 396.000,00 380 RF‐2009‐1473189 Biomaterial funtionalization for orthopaedic and dental use to improve their biofunctionality and osseointegration in healthy and osteopenic bone. 11 biomedica Musculoskeletal, Oral and Skin Sciences € 504.000,00 381 RF‐2009‐1499721 Epigenetic abnormalities as novel targets for treatment in chronic myeloproliferative neoplasms. From genome‐wide methylation analysis to clinical trial. 11 biomedica Oncology 1 ‐ Basic Translational € 500.400,00 382 RF‐2009‐1472992 Imaging of molecular events during mammary tumorigenesis as a novel approach for the identification of new clinically useful tumour biomarkers. 11 biomedica Oncology 1 ‐ Basic Translational € 350.000,00 383 RF‐2009‐1483318 Cerebrospinal fluid proteome from Central Nervous System pediatric tumours: patient related pattern 11 clinico assistenziale Oncology 2 ‐ Translational Clinical € 365.200,00 384 RF‐2009‐1492615 The role of human Erv1 (GFER) and disulphide relay system in mitochondrial diseases 11 biomedica Musculoskeletal, Oral and Skin Sciences € 431.000,00 385 RF‐2009‐1492366 Identification of novel mechanisms of the inflammatory response in cystic fibrosis: A window for therapeutical opportunities 11 biomedica Cardiovascular and Respiratory Sciences € 585.800,00 386 RF‐2009‐1470015 Upstream pathways and downstream effectors regulating the tumorigenic action of eukaryotic Initiation Factor 6 11 biomedica Oncology 1 ‐ Basic Translational € 210.000,00 387 RF‐2009‐1491809 Monocytes as novel biomarkers for the evaluation of cystic fibrosis 11 biomedica Cardiovascular and Respiratory Sciences € 446.250,00 388 RF‐2009‐1492764 Genetic and epigenetic elements in the individual predisposition to lung cancer 11 biomedica Genes, Genomes and Genetics € 488.400,00 389 GR‐2009‐1483296 Role of hypoxia‐induced miR‐210 in tissue response to peripheral ischemia 11 biomedica Vascular and Hematology € 500.000,00 390 RF‐2009‐1493874 Pathogenesis of Multiple Sclerosis: the role of the vitamin D/vitamin D receptor complex 11 biomedica Genes, Genomes and Genetics € 424.600,00 391 RF‐2009‐1547434 Study of vitiligo pathogenesis: lipids and signal transduction alterations 11,17 biomedica Musculoskeletal, Oral and Skin Sciences € 597.500,00 Pagina 34 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 392 RF‐2009‐1476175 Insight into molecular events involved in the cooperation between bcl‐2 and hypoxia in the regulation of tumor progression and angiogenesis 11,17 biomedica Oncology 1 ‐ Basic Translational € 343.200,00 393 GR‐2009‐1560319 Neural basis of social intelligence: a lesion‐based multicenter study on stroke patients 11,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 228.000,00 394 GR‐2009‐1569715 Differentiation therapy of rhabdomyosarcoma with a cocktail of myomiRs 11,25 biomedica Oncology 2 ‐ Translational Clinical € 461.000,00 395 GR‐2009‐1591049 The ubiquitin‐editing protein A20 (TNFAIP3) as a peacekeeper in inflammation and immunity: a link between TNFAIP3 deregulation and Multiple Sclerosis 11,25 biomedica Brain Disorders and Clinical Neuroscience € 294.800,00 396 GR‐2009‐1568646 MITOLESS: genes, mechanisms, and experimental therapy of mtDNA depletion syndromes 11,25 biomedica Genes, Genomes and Genetics € 520.880,00 397 GR‐2009‐1577977 Delivery of adipose tissue‐derived multipotent adult stem cells as a cell therapy approach for treating Collagen VI‐related muscular dystrophies 11,25 biomedica Musculoskeletal, Oral and Skin Sciences € 390.500,00 398 RF‐2009‐1538555 Longitudinal pattern of Streptococcus pneumoniae nasopharyngeal carriage and antimicrobial susceptibility in healthy children aged <=5 years in the metropolitan area of Milan, Northern Italy. 11,25 clinico assistenziale Infectious Diseases and Microbiology 399 GR‐2009‐1536084 MicroRNAs in chronic myeloproliferative neoplasms: profiling, diagnostic and prognostic relevance and therapeutical perspectives 11,25 biomedica Genes, Genomes and Genetics € 383.400,00 400 RF‐2009‐1547948 Search for specific microRNAs as possible biomarkers for early diagnosis of lymphoma in HBV and/or HCV positive patients 11,25 biomedica Oncology 2 ‐ Translational Clinical € 366.300,00 401 GR‐2009‐1527828 Human oocytes ultra‐vitrification by ultra‐fast cooling at low concentration of cryoprotectants 11,25 biomedica Bioengineering Sciences and Technologies € 184.000,00 402 RF‐2009‐1487019 Metabolic markers, MRS detected, to evaluate radiation resistance in cancer (MARE) 11,25 biomedica Oncology 1 ‐ Basic Translational € 594.000,00 403 RF‐2009‐1474270 Monitoring adaptive responses in chronic hepatitis B virus infection as a tool to optimize antiviral therapy 11,25 biomedica Infectious Diseases and Microbiology € 600.000,00 € 152.750,00 Pagina 35 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 404 RF‐2009‐1475171 Nilotinib for steroid‐refractory chronic graft versus host disease 11,25 biomedica Oncology 2 ‐ Translational Clinical € 305.000,00 405 RF‐2009‐1476220 EFFECTS OF SELECTIVE INACTIVATION OF THE DYT1 GENE IN STRIATAL CHOLINERGIC NEURONS: PATHOPHYSIOLOGICAL IMPLICATIONS FOR DYT1 DYSTONIA 11,25 biomedica Molecular, Cellular, and Developmental Neuroscience € 330.750,00 406 GR‐2009‐1503776 Nanostructured scaffolds for the regeneration of nervous system injuries 11,25 biomedica Bioengineering Sciences and Technologies € 593.000,00 407 RF‐2009‐1504768 Development of radio‐labeled nanodevices decorated with matrix metalloproteinases inhibitors as nanoscopic imaging agents for cancer detection: synthesis, chemical and biological characterization and micro‐imaging in a mouse model of colorectal cancer 11,25 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 400.000,00 408 RF‐2009‐1473354 Strategies for preservation of the ovarian reserve in cancer therapy and autoimmunity conditions. 11,25 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 300.000,00 409 RF‐2009‐1511378 Dietary restriction and GH/IGF‐I axis involvement in the mechanisms of differential cellular protection: a strategy to enhance the efficacy of cancer chemotherapy. 11,34 biomedica Oncology 1 ‐ Basic Translational € 350.000,00 410 RF‐2009‐1530888 A NOVEL DIFFUSION TENSOR MR‐BASED APPROACH TO EVALUATE STRUCTURAL FEATURES OF BRAIN TUMORS 11,34 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 480.000,00 411 RF‐2009‐1486929 New approaches for cancer therapy based on manipulation of the tumor vascular physiology with chromogranin A and its fragments 11,34 biomedica Oncology 1 ‐ Basic Translational € 450.000,00 412 RF‐2009‐1475862 Novel bioactive small‐diameter vascular grafts able to reduce initial thrombosis and to accelerate in vivo endothelialisation 11,34 biomedica Bioengineering Sciences and Technologies € 591.000,00 413 GR‐2009‐1553846 Defining cancer stem cell pathogenic mechanisms by modulating developmental transcription factor genes in keratinocytes 11,5 biomedica Oncology 1 ‐ Basic Translational € 440.000,00 414 RF‐2009‐1524206 Early Environmental Determinants of Child Development and Respiratory Health: a Birth Cohort Study in Central Italy 11,5 clinico assistenziale Population Sciences and Epidemiology € 600.000,00 Pagina 36 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 415 GR‐2009‐1608112 Development of a neuro‐anatomical model for assessing and predicting cognitive deficits associated with parietal lesions 11,5 biomedica Biobehavioral and Behavioral Processes 416 RF‐2009‐1528643 In search for biomarkers predicting coronary bypass graft patency: Identification of molecular signatures of inflammation and coagulation. 11,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 599.600,00 417 RF‐2009‐1523713 High‐throughput Exome sequencing analysis of 300 subjects with mental retardation 11,5 biomedica Genes, Genomes and Genetics € 425.000,00 418 RF‐2009‐1530756 Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cell‐permeable peptides in preclinical models 11,5 biomedica Brain Disorders and Clinical Neuroscience € 300.000,00 419 RF‐2009‐1539594 MMP9‐mediated role of SCF/Bad patwhay in the progression of atherosclerosis: exploring the possibility to modulate carotid plaque growth 11,5 biomedica Vascular and Hematology € 510.000,00 420 RF‐2009‐1525669 Clinical and genetic study of early onset epilepsies of unknown aetiology 11,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 197.500,00 421 RF‐2009‐1521600 Probiotic Lactobacillus strains: preclinical study to assess their potential immunomodulatory effect in Myasthenia Gravis and its experimental model 11,5 biomedica Brain Disorders and Clinical Neuroscience € 415.265,00 422 RF‐2009‐1547527 Identification of genetic and environmental risk factors in migraine: first multicentric Italian Genome Wide Association Study 11,5 biomedica Genes, Genomes and Genetics € 600.000,00 423 RF‐2009‐1548426 Allogeneic hematopoietic stem cell transplantation from HLA‐matched donors in patients with familial amyotrophic lateral sclerosis 11,5 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 424 GR‐2009‐1606835 How Corpus Callosum changes in Alzheimer's Disease and in different forms of degenerative dementias 11,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 473.000,00 425 RF‐2009‐1529528 Mathematical‐biophysics models to assess the effects of the dynamical interplay between tumour cells in a solid tumour undergoing a drug‐based therapy 11,5 biomedica Bioengineering Sciences and Technologies € 303.333,00 426 GR‐2009‐1606346 Development of analytical methods to identify treatments with recombinant somatotropin in buffalos 11,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 281.000,00 € 453.310,00 Pagina 37 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 427 GR‐2009‐1591313 Parkinsons disease: effects of the aging on progenitor neural cells and bone marrow stromal cells 11,5 biomedica Brain Disorders and Clinical Neuroscience € 210.000,00 428 GR‐2009‐1594597 Development of a biological profile to predict cognitive decline and dementia in the elderly and to monitor the effects of preventive interventions 11,5 biomedica Population Sciences and Epidemiology € 522.000,00 429 GR‐2009‐1545682 Imaging in MR spectroscopy: reconstruction of high spatial resolution metabolic maps 11,5 biomedica Bioengineering Sciences and Technologies € 375.000,00 430 RF‐2009‐1549683 DETERMINATION IF LACK OF VARIABILITY IN CARDIAC R‐R INTERVAL ON EKG PREDICTS THE DEVELOPMENT OF THE CLASSIC MOTOR FEATURES OF PARKINSONS DISEASE. 11,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 596.000,00 431 GR‐2009‐1606765 Implication of the transcription factor Yin Yang‐1 in B‐cell non‐Hodgkin lymphoma development and progression 11,5 biomedica Oncology 1 ‐ Basic Translational € 200.000,00 432 GR‐2009‐1605555 A Double‐Blind, Multicenter, Randomized, Placebo‐controlled Study to Investigate the Impact of Serum Phosphorous Control on Kidney Disease Progression and Mortality in Moderate to Advanced Non‐dialysis‐dependent Kidney Dysfunction 11,5 clinico assistenziale Population Sciences and Epidemiology € 554.320,00 433 GR‐2009‐1546047 Phase II study of interleukin‐2 and zoledronic acid as maintenance therapy in multiple myeloma patients undergoing autografting 11,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 347.500,00 434 GR‐2009‐1605075 TAVI versus traditional approaches in treating severe symptomatic aortic stenosis 11,5 clinico assistenziale Healthcare Delivery and Methodologies € 380.000,00 435 GR‐2009‐1575612 Respiratory gated PET/CT technique and 18F‐FAZA for the evaluation of hypoxia in non small cell lung cancer (NSCLC) 11,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 600.000,00 436 RF‐2009‐1511276 INFLUENCE OF GENETIC AND GENOMIC BACKGROUND ON RESISTANCE TO ANTIVIRAL THERAPY, PREDISPOSITION TO DEVELOP HEPATOCELLULAR CARCINOMA AND SEVERITY OF RECURRENCE AFTER LIVER TRANSPLANT IN CHRONIC HEPATITIS C PATIENTS. 11,5 biomedica Genes, Genomes and Genetics € 568.050,00 437 RF‐2009‐1499157 Analysis of current dynamics of tuberculosis in a low incidence country 11,5 clinico assistenziale Population Sciences and Epidemiology € 520.000,00 Pagina 38 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 438 RF‐2009‐1471093 Genetics and Pathogenesis of Steroid Resistant Nephrotic Syndrome 11,5 biomedica Genes, Genomes and Genetics € 345.200,00 439 RF‐2009‐1483329 Utilization of Regional Health Service databases for evaluating epidemiology, short‐ and medium‐term outcome, and process indexes in patients hospitalized for heart failure. 11,5 clinico assistenziale Healthcare Delivery and Methodologies € 442.000,00 440 RF‐2009‐1472165 Development of new vaccines for animal salmonellosis 11,5 biomedica Veterinary ‐ Animal Health ‐ ANHE € 530.000,00 441 RF‐2009‐1470082 Developing Therapeutic Strategies Based on Intra‐Bone Transplant of Hematopoietic Stem Cells 11,5 biomedica Vascular and Hematology € 244.650,00 442 RF‐2009‐1469205 Identification and validation of biological outcome predictors in mantle cell lymphoma 11,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 360.000,00 443 GR‐2009‐1499610 New antimicrobial agents targeting antibiotic resistance mechanisms and novel or underexploited targets 11,5 biomedica Infectious Diseases and Microbiology € 528.000,00 444 RF‐2009‐1472961 Early diagnosis of pending failures of total hip arthroplasty with hard‐to‐hard bearings 11,5 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 335.000,00 445 GR‐2009‐1492607 Genetic elements linking inflammatory responsiveness to lung cancer susceptibility 11,5 biomedica Genes, Genomes and Genetics € 320.650,00 446 RF‐2009‐1472425 Novel molecular targets against drug‐resistant bacterial and protozan infections 11,5 biomedica Biological Chemistry and Macromolecular Biophysics € 400.000,00 447 RF‐2009‐1504341 Thrombolysis with r‐TPA for wake‐up stroke patients within 3 hours of symptoms awareness: a multi‐centre randomized open label controlled study 11,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 500.000,00 448 RF‐2009‐1471235 OXIDATIVE STRESS, AGEING, AND RESPIRATORY DISEASES. A multi‐centre epidemiological and genetic study on the general adult and elderly population in Italy. 11,5 clinico assistenziale Healthcare Delivery and Methodologies € 401.500,00 449 RF‐2009‐1546284 MOBI‐KIDS Italy ‐ Brain cancer risk from exposure to radiofrequency fields in childhood and adolescence: a multicentric international study 11,67 clinico assistenziale Population Sciences and Epidemiology € 475.000,00 Pagina 39 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 450 RF‐2009‐1538407 Identification of New Early Biomarkers in Kidney Malignancies 11,67 biomedica Digestive, Kidney and Urological Systems € 450.000,00 451 GR‐2009‐1570531 Human Well‐Being: a Twin Study on the Relation between Optimal Psychological and Biological Functioning 11,75 biomedica Biobehavioral and Behavioral Processes € 500.000,00 452 RF‐2009‐1549489 Role of innate immunity in human herpes simplex virus (HSV)‐1 infection and its related neuropathologies. 11,75 biomedica Immunology € 600.000,00 453 GR‐2009‐1566928 Combining microarrays, computational biology and molecular immunology: innovative diagnosis and vaccine discovery for Pneumococcal diseases 11,75 biomedica Bioengineering Sciences and Technologies € 495.200,00 454 RF‐2009‐1530982 DEVELOPMENT OF NOVEL BETA‐GLUCAN‐BASED, GLYCOCONJUGATE VACCINES AND ANTI‐BETA‐GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS 11,75 biomedica Immunology € 595.000,00 455 GR‐2009‐1578292 Genomewide evaluation of genetic factors associated with progressive non‐ alcoholic steatohepatitis by an Italian research network 11,75 biomedica Genes, Genomes and Genetics € 600.000,00 456 GR‐2009‐1579648 A zebrafish‐based integrated biosensor for molecular diagnosis, multi‐organ analysis and drug screening in Alagille syndrome 11,75 biomedica Genes, Genomes and Genetics € 390.000,00 457 GR‐2009‐1591908 Hemodynamic Neurotechnology for Stroke Rehabilitation 11,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 407.000,00 458 GR‐2009‐1600536 Human Cytomegalovirus, Adenovirus and Epstein Barr virus infection and cellular immune response: factors associated to prevention of congenital infection and correlates of protection in transplanted patients. 11,75 biomedica Immunology € 465.000,00 459 GR‐2009‐1605621 Role of uPAR in the epidermal stem cell compartment, skin carcinogenesis and hair follicle regeneration. 11,75 biomedica Musculoskeletal, Oral and Skin Sciences € 600.000,00 460 GR‐2009‐1596540 The capacity to consent to treatment in Amyotrophic Lateral Sclerosis 11,75 clinico assistenziale Healthcare Delivery and Methodologies € 152.000,00 461 RF‐2009‐1547121 Risk evaluation associated with Legionella water system contamination: data interpretation from Viability PCR , Real‐time PCR and culture. 11,75 clinico assistenziale Infectious Diseases and Microbiology € 522.500,00 Pagina 40 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 462 GR‐2009‐1595813 Assessment of neuropsychological and neurobiological effects in adult life of prenatal and early postnatal stress experiences 11,75 biomedica Biobehavioral and Behavioral Processes € 503.800,00 463 GR‐2009‐1607193 Molecular Changes in Endocrine Resistant Breast Cancer: Relationship between Hormone Receptor and Growth Factor Receptor Family 11,75 biomedica Oncology 2 ‐ Translational Clinical € 510.000,00 464 GR‐2009‐1607388 Mindfulness‐Based Cognitive Therapy for patients with Amyotrophic Lateral Sclerosis: a Randomized Controlled Trial 11,75 clinico assistenziale Biobehavioral and Behavioral Processes € 223.200,00 465 RF‐2009‐1509176 A Comprehensive clinical approach to Rare Tumours: From genetics to targeted clinical approach. 11,75 biomedica Oncology 2 ‐ Translational Clinical € 598.950,00 466 GR‐2009‐1539786 Identification of candidate disease genes in familial Amyotrophic Lateral Sclerosis using a targeted exon capture and resequencing approach 11,75 biomedica Brain Disorders and Clinical Neuroscience € 579.000,00 467 GR‐2009‐1607709 Exosomes as diagnostic markers for prion diseases: exploiting the infectivity vehicle 11,75 biomedica Infectious Diseases and Microbiology € 446.814,00 468 RF‐2009‐1503110 Function of Rac1 and Rac3 GTPases in the development of cortical and hippocampal interneurons. 11,75 biomedica Molecular, Cellular, and Developmental Neuroscience € 420.000,00 469 RF‐2009‐1500900 Myeloid‐derived suppressor cells, purinergic signalling, and tumor immunity 11,75 biomedica Immunology € 600.000,00 470 RF‐2009‐1488377 CD99 bridges molecular therapy to differentiation of bone sarcoma 11,75 biomedica Oncology 1 ‐ Basic Translational € 368.500,00 471 RF‐2009‐1492263 Treatment of neuromuscular diseases by inhibition of dystroglycan proteolysis 11,75 biomedica Molecular, Cellular, and Developmental Neuroscience € 600.000,00 472 RF‐2009‐1499202 Randomized clinical trial comparing the safety and efficacy of the use of fixed‐ dose combination efavirenz/tenofovir/emtricitabine (Atripla®) on alternate days versus continuous treatment 11,75 clinico assistenziale AIDS and Related Research € 267.500,00 473 RF‐2009‐1492228 CDKL5 gene: clinical phenotype and effects of mutations on development of the central nervous system in view of future therapeutic approaches 11,75 biomedica Brain Disorders and Clinical Neuroscience € 396.756,00 Pagina 41 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 474 RF‐2009‐1530517 Characterization of the tick‐Anaplasma interface: Development of vaccines for the integrated control of tick infestations and the transmission of tick‐borne pathogens, A. marginale and A. phagocytophilum. 11,84 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 475 RF‐2009‐1538661 Indicators of diabetes and cardiovascular risk and therapy efficacy in subjects with early impairment of glucose metabolism. 11,84 biomedica Genes, Genomes and Genetics € 599.500,00 476 RF‐2009‐1511346 Multicenter randomized study on the efficacy of immunosuppression in patients with virus‐negative inflammatory cardiomyopathy 11,84 clinico assistenziale Cardiovascular and Respiratory Sciences € 473.000,00 477 RF‐2009‐1498887 Familial breast cancer: low‐risk alleles, genetic modifiers and screen for variants in associated genes/loci. 11,84 biomedica Oncology 1 ‐ Basic Translational 478 GR‐2009‐1502408 Epidemiology and Genomics of taste, food preferences and Healthy Eating in three Italian Isolated Populations 11,84 biomedica Genes, Genomes and Genetics € 227.900,00 479 RF‐2009‐1510916 GABAergic dysfunction in the development and etiology of childhood and adult intractable epilepsies 12 biomedica Brain Disorders and Clinical Neuroscience € 293.000,00 480 GR‐2009‐1606634 Inhibition of adrenal beta‐arrestin 1 signaling pathway as a new therapeutic target to counteract the adverse effects of heart failure‐related hyperaldosteronism. 12 biomedica Cardiovascular and Respiratory Sciences € 450.100,00 481 GR‐2009‐1606536 The local control of thyroid hormone action in skin tumorigenesis and in the treatment of basal cell carcinomas 12 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 326.000,00 482 GR‐2009‐1505912 Melanocortin‐1 receptor variants in skin carcinogenesis: a pooled analysis 12 biomedica Oncology 1 ‐ Basic Translational € 170.000,00 483 GR‐2009‐1608697 Construction of microfluidic‐device to detect protein trace present in ocular liquid to monitor chronic brain diseases 12 biomedica Bioengineering Sciences and Technologies € 410.300,00 484 RF‐2009‐1529938 ITALIAN OBSERVATIONAL STUDY ON VEGETATIVE STATE 12 clinico assistenziale Healthcare Delivery and Methodologies € 360.000,00 485 RF‐2009‐1546221 Non human primate model for HIV/AIDS: a platform to generate and evaluate therapeutic antibodies against structural and non structural proteins of HIV‐1. 12 biomedica AIDS and Related Research € 597.850,00 € 337.333,00 Pagina 42 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 486 RF‐2009‐1524387 Cerebrospinal Fluid Ceruloplasmin oxidation as Parkinsons Disease Biomarker: role in pathological mechanisms 12 biomedica Brain Disorders and Clinical Neuroscience € 330.000,00 487 RF‐2009‐1511846 Health outcomes at school age of a population‐based cohort of very preterm infants: the ACTION III project 12 clinico assistenziale Population Sciences and Epidemiology € 299.200,00 488 RF‐2009‐1521775 The interplay between innate and adaptive immunity in the initial steps of chronic inflammatory diseases: psoriasis as a model 12 biomedica Immunology € 350.000,00 489 RF‐2009‐1511552 Biomolecular characterization of methylation and new histone deacetylase inhibitors: implications for cancers and their treatment. 12 biomedica Oncology 1 ‐ Basic Translational € 172.000,00 490 GR‐2009‐1607226 A look into the exciting network of Myospryn 12 biomedica Cardiovascular and Respiratory Sciences € 490.000,00 491 GR‐2009‐1606663 VALIDATION OF MPI AS PROGNOSTIC INDEX FOR ELDERLY CANCER PATIENTS; EVALUATION OF COMORBIDITY, POLIPHARMACOLOGY AND POTENTIAL DRUG INTERACTIONS; PAIN ASSESSMENT AND TREATMENT AND CORRELATION WITH QUALITY OF LIFE IN ELDERLY (AGE > 70 YEARS) PATIENTS WITH CA 12 clinico assistenziale Oncology 2 ‐ Translational Clinical € 190.000,00 492 RF‐2009‐1549299 FETAL HEMOGLOBIN INDUCTION IN BETA‐THALASSEMIA: ROLE OF BCL11A AND MYB IN MEDIATING THE EFFECT OF KIT LIGAND AND THALIDOMIDE, RESPECTIVELY 12 biomedica Vascular and Hematology € 339.900,00 493 GR‐2009‐1607828 Pharmacogenetics of analgesic drugs: towards a personalized medicine for treatment of neuropathic pain 12 biomedica Genes, Genomes and Genetics € 573.320,00 494 RF‐2009‐1546112 Mechanism of interaction between osteoclast and T cells in periprosthetic osteolysis: new perspectives for an early diagnosis 12 biomedica Musculoskeletal, Oral and Skin Sciences € 170.000,00 495 RF‐2009‐1530657 Novel cellular and molecular mechanisms in the pathogenesis of chronic obstructive pulmonary disease 12 biomedica Cardiovascular and Respiratory Sciences € 256.000,00 496 GR‐2009‐1607361 Identification of myogenic precursor cells forming new myofibers in regenerating skeletal muscle for the cell therapy of the muscular dystrophy. 12 biomedica Musculoskeletal, Oral and Skin Sciences € 525.000,00 Pagina 43 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 497 GR‐2009‐1607316 Assessment of the safety of antipsychotic drugs in elderly with dementia: an international, population‐based study using healthcare databases 12 clinico assistenziale Brain Disorders and Clinical Neuroscience 498 GR‐2009‐1607680 ROLE OF THE ACTIN REGULATORY PROTEINS, EPS8 AND IRSp53, IN THE PROGRESSION OF ORAL SQUAMOUS CELL CARCINOMA. 12 biomedica Oncology 1 ‐ Basic Translational € 493.333,00 499 GR‐2009‐1553657 Defining Estrogen Receptor‐beta selective agonists as candidate molecules for the medical therapy of cholangiocarcinoma 12 biomedica Oncology 1 ‐ Basic Translational € 215.400,00 500 RF‐2009‐1549885 MULTIDISCIPLINARY AND COMPREHENSIVE KNOWLEDGE ON BONE DISORDERS IN HIV INFECTION: CLINICAL‐EPIDEMIOLOGICAL FACTORS, RISK SCORES, INTEGRATED DIAGNOSTIC IMAGING AND BASIC SCIENCES. SKELETON STUDY 12 clinico assistenziale AIDS and Related Research € 362.500,00 501 RF‐2009‐1543210 Analysis of peripheral biomarkers to evaluate the efficacy of acetylcholinesterase inhibitor and antiglutamatergic drugs in Alzheimer's disease 12 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 502 RF‐2009‐1536741 PROTECTIVE AND DANGEROUS IMMUNE RESPONSES IN HIV‐INFECTED CHILDREN 12 biomedica AIDS and Related Research € 584.100,00 503 RF‐2009‐1509167 GENETIC TESTING BY ARRAY‐BASED COMPARATIVE GENOMIC HYBRIDISATION IN AUTISM SPECTRUM DISORDERS 12 biomedica Genes, Genomes and Genetics € 582.000,00 504 RF‐2009‐1531236 HMGB1 in the treatment of the failing heart 12 biomedica Cardiovascular and Respiratory Sciences € 600.000,00 505 GR‐2009‐1580055 Pain‐free Microneedle‐based Integrated Glycemic Holter for Metabolic Control of Patients with Diabetes Mellitus (MICROHOLTER) 12 biomedica Bioengineering Sciences and Technologies € 600.000,00 506 RF‐2009‐1547069 Comparative Effectiveness of Treatments for Degenerative Spine Disease 12 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 200.000,00 507 RF‐2009‐1524299 Effectiveness and cost‐effectiveness of new organizational integrated home care models 12 clinico assistenziale Healthcare Delivery and Methodologies € 256.000,00 508 RF‐2009‐1524267 Resistin and cardiovascular risk in type 2 diabetes 12 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 385.200,00 € 470.000,00 Pagina 44 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 509 GR‐2009‐1576371 A new tool for individual risk assessment of prostate cancer patients 12 biomedica Oncology 1 ‐ Basic Translational € 247.800,00 510 RF‐2009‐1524706 Novel molecular players in melanoma growth and progression. 12 biomedica Oncology 1 ‐ Basic Translational € 516.000,00 511 RF‐2009‐1546134 Detection of diarrhoea‐causing protozoa by multiplex real‐time PCR assays 12 biomedica Infectious Diseases and Microbiology € 220.000,00 512 GR‐2009‐1526395 Role of fibroblasts in intestinal inflammation: implications for celiac disease therapy and diagnosis 12 biomedica Digestive, Kidney and Urological Systems € 370.000,00 513 GR‐2009‐1595852 Development of innovative adipose tissue mesenchymal stem cell‐based strategies for bone tissue regeneration using pharmacological agents 12 biomedica Cell Biology € 208.000,00 514 RF‐2009‐1532869 Muteins of human NGF with therapeutic potential for Alzheimers Disease: expression, production and pharmacological studies 12 biomedica Molecular, Cellular, and Developmental Neuroscience € 402.000,00 515 GR‐2009‐1594648 Evaluation of an innovative approach for motor rehabilitation after stroke by manipulating central pathways: a physical and pharmacological intervention 12 biomedica Brain Disorders and Clinical Neuroscience € 155.000,00 516 GR‐2009‐1591226 Role of leukocyte telomere length and CD34+ hematopoietic precursor telomerase activity in the pathogenesis of cellular senescence in diabetic nephropathy. 12 biomedica Digestive, Kidney and Urological Systems € 363.120,00 517 GR‐2009‐1580040 Genetic Variation Of Dopamine D2 Receptor And Response to Antipsychotics In Patients With Behavioural And Psychological Symptoms Of Dementia 12 biomedica Biobehavioral and Behavioral Processes 518 RF‐2009‐1527420 Development of a new vaccine against tuberculosis 12 biomedica Immunology 519 RF‐2009‐1527419 ARTEMIS (Augmented Realism in Teleconsulting and Education in Minimally Invasive Surgery) 12 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 588.500,00 520 RF‐2009‐1527400 Tumorgraft models for the discovery of the molecular culprits of rectal cancer and the design of patient specific therapeutic protocols 12 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 521 RF‐2009‐1548577 TRANSMISSION OF CREUTZFELDT‐JAKOB DISEASE BY BLOOD: EPIDEMIOLOGICAL AND EXPERIMENTAL TRANSMISSION STUDIES 12 biomedica Population Sciences and Epidemiology € 470.000,00 € 599.500,00 € 321.100,00 Pagina 45 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 522 RF‐2009‐1531393 Development of new experimental models for mental retardation and autism by studying Shank3 and IL1RAPL1 function in synapse formation using iPS technology 12 biomedica Brain Disorders and Clinical Neuroscience € 330.000,00 523 GR‐2009‐1580063 Proteomic and lipidomic investigations in Multiple Sclerosis: research of molecular biomarkers 12 biomedica Biological Chemistry and Macromolecular Biophysics € 236.000,00 524 RF‐2009‐1530985 TRAIL‐producing UC‐MSCs as cell‐based therapy for multiple myeloma: a preclinical study 12 biomedica Oncology 1 ‐ Basic Translational € 469.000,00 525 RF‐2009‐1534860 Assessment and control of selected priority contaminants intake through the characterisation of rural and indoor environments ‐ ENVI FOOD 12 biomedica Veterinary ‐ Food Safety ‐ FOSA € 595.000,00 526 GR‐2009‐1601037 Preventive and therapeutic effects of zinc‐oxide and silver particles on bacteria involved in caries pathogenesis 12 biomedica Bioengineering Sciences and Technologies € 403.000,00 527 RF‐2009‐1546552 Lineage control of muscle‐derived adult stem cells by miRNA‐mediated regulation of the composition of the SWI/SNF chromatin remodeling complex 12 biomedica Musculoskeletal, Oral and Skin Sciences € 300.000,00 528 GR‐2009‐1594951 Role of the transcription factor Nfix in muscle regeneration and muscular dystrophies 12 biomedica Musculoskeletal, Oral and Skin Sciences € 0,00 529 RF‐2009‐1546550 The effect of blindness and visual impairment on neurocognitive mechanisms: clinical and rehabilitative implications 12 biomedica Biobehavioral and Behavioral Processes € 295.000,00 530 GR‐2009‐1596137 Evaluation of two Adapted Physical Activity (APA) training programs on cardiopulmonary parameters, inflammatory cytokines response, nutrients intake and body composition in subjects affected by chronic obstructive pulmonary disease (COPD). 12 clinico assistenziale Biology of Development and Aging € 569.800,00 531 GR‐2009‐1594838 BBB and inflammation in epilepsy: novel targets for pharmacological intervention 12 biomedica Brain Disorders and Clinical Neuroscience € 520.000,00 532 RF‐2009‐1471185 Genetic tauopathies: the involvement of tau protein in chromosome stability as a cause of neurodegeneration 12 biomedica Brain Disorders and Clinical Neuroscience € 304.700,00 533 RF‐2009‐1475906 Lost HuB: cell cycle deregulation and suppression of neuronal differentiation by a tumor suppressor candidate in gliomas 12 biomedica Oncology 1 ‐ Basic Translational € 465.300,00 Pagina 46 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 534 RF‐2009‐1504288 Evaluation of bacteriocins safety and efficacy as a strategy to control Campylobacter in poultry chain 12 biomedica Veterinary ‐ Food Safety ‐ FOSA € 478.500,00 535 RF‐2009‐1469133 Modulation of the NAD salvage pathway as a novel pharmacological approach for spinal cord injury 12 biomedica Brain Disorders and Clinical Neuroscience € 496.000,00 536 RF‐2009‐1468798 Enhancing cell proliferation in favor of regenerative medicine 12 biomedica Musculoskeletal, Oral and Skin Sciences € 354.444,00 537 RF‐2009‐1472402 BONE TISSUE REGENERATION FOR THE TREATMENT OF CONGENITAL PSEUDARTHROSIS OF THE TIBIA 12 biomedica Musculoskeletal, Oral and Skin Sciences € 360.000,00 538 RF‐2009‐1493195 Nano‐structured coatings enhance biomaterials performance for joint reconstruction 12 biomedica Bioengineering Sciences and Technologies € 450.000,00 539 GR‐2009‐1492099 A Cellular Model to Predict Disease Evolution and Response to Treatment in Patients with Systemic Mastocytosis 12 biomedica Vascular and Hematology € 300.000,00 540 RF‐2009‐1472623 THE UP‐REGULATION OF BACE1 AS PARADIGM OF THE PHYSIOLOGIC AND PATHOLOGIC EFFECTS OF BETA‐AMYLOID 42 12 biomedica Brain Disorders and Clinical Neuroscience € 300.000,00 541 RF‐2009‐1472066 Immunoproteomic, host‐parasite interaction and molecular epidemiology of Echinococcus granulosus 12 biomedica Infectious Diseases and Microbiology € 271.000,00 542 RF‐2009‐1469214 Post‐transcriptional control of gene expression and cancer. 12 biomedica Genes, Genomes and Genetics € 259.325,00 543 RF‐2009‐1504361 LONG‐TERM PROGNOSIS OF EPILEPSY. A multi‐center retrospective survey of prognostic patterns in newly diagnosed patients 12 clinico assistenziale Population Sciences and Epidemiology € 413.400,00 544 RF‐2009‐1476146 Histone deacetylase inhibitors as anti‐inflammatory drugs: dissecting molecular mechanisms and targets 12 biomedica Immunology € 600.000,00 545 RF‐2009‐1468605 EGFR expression identifies distinct tumor‐initiating cells in human glioblastoma multiforme: selection and functional validation of an EGFR‐associated TIC‐specific molecular signature with potential predictive value. 12 biomedica Oncology 1 ‐ Basic Translational € 350.000,00 Pagina 47 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 546 RF‐2009‐1471511 Innovative and integrated approaches to understand the genetic bases of hearing loss 12 biomedica Genes, Genomes and Genetics € 282.300,00 547 RF‐2009‐1474486 Fibrin resistance to lysis in pulmonary hypertension 12 biomedica Cardiovascular and Respiratory Sciences € 157.960,00 548 RF‐2009‐1468033 Identification of genes for rare neurological traits by homozygosity mapping and exome sequencing 12 biomedica Genes, Genomes and Genetics € 399.000,00 549 RF‐2009‐1471418 UNDERSTANDING PODOCYTE SIGNALING TO IMPROVE DIAGNOSIS AND TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS 12 biomedica Digestive, Kidney and Urological Systems € 396.000,00 550 RF‐2009‐1485953 Discovery of a new class of drugs aimed at reducing HIV latent reservoirs: HIV‐1 Tat‐mimicking compounds 12 biomedica AIDS and Related Research € 220.000,00 551 RF‐2009‐1492906 Therapeutic potential based on neural plasticity induced by the Rho GTPase activator CNF1: the case of Rett syndrome and neurophatic pain 12 biomedica Molecular, Cellular, and Developmental Neuroscience € 576.840,00 552 RF‐2009‐1494510 Relationships between receptor‐tranducer selectivity and tolerance to opioid ligands 12 biomedica Molecular, Cellular, and Developmental Neuroscience € 229.000,00 553 GR‐2009‐1470694 Regulation of Wnt signaling for bone regeneration in localized bone defects 12 biomedica Musculoskeletal, Oral and Skin Sciences € 360.500,00 554 RF‐2009‐1483806 Molecular crosstalk between cancer and aging: The p53‐p66Shc signalling pathway. 12 biomedica Biology of Development and Aging € 368.300,00 555 RF‐2009‐1469625 Identification of beta cell specific aptamers as in vivo imaging tools in diabetes mellitus 12 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 575.000,00 556 RF‐2009‐1487943 IMmunity, Inflammation and Carotid ATherosclerosis: The IMICAT study 12 biomedica Vascular and Hematology € 585.200,00 557 GR‐2009‐1473401 THE PROTEIN C PATHWAY IS A NOVEL MEDIATOR IN INTESTINAL HOMEOSTASIS: therapeutic implications for inflammatory bowel disease treatment 12 biomedica Vascular and Hematology € 600.000,00 Pagina 48 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 558 RF‐2009‐1469576 MicroRNAs role in aging‐dependent impairment of angiogenesis 12 biomedica Biology of Development and Aging € 600.000,00 559 RF‐2009‐1504070 Regulatory T cells at tumor site: phenotype diversity and functional implication 12 biomedica Oncology 2 ‐ Translational Clinical € 265.650,00 560 RF‐2009‐1544560 Spinocerebellar ataxia type 28, from molecular hypothesis to preclinical treatment 12,17 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 561 GR‐2009‐1594540 Validation of autoimmunity to PDGF receptor as a pathogenic mechanism in scleroderma 12,17 biomedica Musculoskeletal, Oral and Skin Sciences € 275.000,00 562 GR‐2009‐1606735 ReShape: Evaluation of possible determinants for early and late cardiac remodeling after mitral valve repair with annuloplasty using new computational tools. 12,17 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 503.300,00 563 RF‐2009‐1505910 Evaluation of advanced technologies to improve sensitivity and throughput of multiplex immunoassays for diagnosis of animal infectious diseases 12,17 biomedica Veterinary ‐ Animal Health ‐ ANHE € 345.000,00 564 GR‐2009‐1571862 The role of natural selection in shaping the genetic predisposition to chronic inflammatory diseases: multiple sclerosis and inflammatory bowel disease 12,17 biomedica Genes, Genomes and Genetics € 525.000,00 565 RF‐2009‐1474008 Bone disorders in chronic liver diseases: identification of cellular and molecular mechanisms 12,17 biomedica Musculoskeletal, Oral and Skin Sciences € 462.000,00 566 RF‐2009‐1546865 Magnetic Cardiac Targeting of Thermomagnetoliposomes entrapping L‐T3 to reverse ischemic myocardial remodeling in pigs. 12,2 biomedica Cardiovascular and Respiratory Sciences € 599.940,00 567 GR‐2009‐1601017 Facing the Pandemic Influenza virus threat: development of RNA interference‐ based innovative therapeutic approaches, targeting the anti interferon NS‐1 viral gene product. 12,25 biomedica Infectious Diseases and Microbiology € 590.150,00 568 GR‐2009‐1545579 TOWARD A THERAPEUTIC APPROACH IN CONGENITAL CENTRAL HYPOVENTILATION SYNDROME (CCHS): IN VITRO IDENTIFICATION OF DRUGGABLE PHOX2B TARGETS AND SCREENING OF EFFECTIVE PHARMACEUTICAL AGENTS 12,25 biomedica Molecular, Cellular, and Developmental Neuroscience € 417.500,00 Pagina 49 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 569 GR‐2009‐1607566 Alternative splicing as a tool to identify novel angiogenesis modulators for therapeutic purposes 12,25 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 570 GR‐2009‐1608490 Epigenetic Risk Assesment (ERA) of Assisted Reproductive Technologies (ART) 12,25 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 600.000,00 571 GR‐2009‐1606131 Microsomal Prostaglandin E synthase type‐1 as a therapeutical target in controlling tumor progression and angiogenesis promoted by EGFR/K‐Ras 12,25 biomedica Oncology 2 ‐ Translational Clinical € 356.500,00 572 RF‐2009‐1531687 New methods for sentinel lymph node mapping and intraoperative analysis by One Step Nucleic Acid Amplification (OSNA) in breast cancer patients: identification of new biological parameters correlated with sentinel and non‐ sentinel lymph node metastases 12,25 biomedica Oncology 2 ‐ Translational Clinical € 363.000,00 573 RF‐2009‐1526479 Primary progressive aphasia. Development and validation of a standardized diagnostic procedure in Italian patients 12,25 biomedica Brain Disorders and Clinical Neuroscience € 500.000,00 574 RF‐2009‐1519827 Levosimendan to reduce mortality in high risk cardiac surgery patients. A multicentre randomized controlled trial 12,25 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 600.000,00 575 GR‐2009‐1577841 ROLE OF CHIKUNGUNYA VIRUS GENETIC VARIABILITY IN PATHOGENETIC MECHANISMS 12,25 biomedica Infectious Diseases and Microbiology € 360.000,00 576 RF‐2009‐1536140 Translational Study on Neuroprotective Role of Conjuctivally Applied Nerve Growth Factor in Childhood Optic Gliomas 12,25 clinico assistenziale Brain Disorders and Clinical Neuroscience 577 GR‐2009‐1545513 Implementation of functional Magnetic Resonance Imaging techniques on the first Italian 7 Tesla Magnet 12,25 biomedica Emerging Technologies and Training in Neurosciences € 390.000,00 578 RF‐2009‐1475250 Exome sequencing in diagnosis of rare hereditary anemias 12,25 biomedica Genes, Genomes and Genetics € 396.000,00 579 RF‐2009‐1475557 Molecular basis of sporadic and familial Amyotrophic Lateral Sclerosis in Italy: a morbidity map of disease genes 12,25 biomedica Brain Disorders and Clinical Neuroscience € 243.000,00 € 341.700,00 Pagina 50 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 580 RF‐2009‐1473696 18F‐FDG‐PET as a predictor of response to cognitive rehabilitation for mild cognitive impairment 12,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 597.629,00 581 RF‐2009‐1528612 From micro GIST to macro GIST: dissection of the molecular pathways that underlie the malignant evolution of GIST 12,34 biomedica Oncology 1 ‐ Basic Translational € 500.000,00 582 RF‐2009‐1548551 Clinical and molecular investigation of HPV‐associated anal cancer precursors in immunocompetent and immunocompromised hosts. 12,34 biomedica Oncology 1 ‐ Basic Translational € 492.000,00 583 GR‐2009‐1580050 Endocytosis, Notch signaling and tumor suppression: From flies to human cancer 12,34 biomedica Cell Biology € 491.666,00 584 GR‐2009‐1604756 In‐vivo non‐invasive optical diagnosis of skin lesions 12,34 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 439.000,00 585 RF‐2009‐1484987 Study of autophagy dysregulation in Parkinson's Disease for the identification of new diagnostic markers using bio‐engineered neural cells obtained from the chemical reprogramming of easily accessible dermal fibroblasts 12,34 biomedica Brain Disorders and Clinical Neuroscience € 453.000,00 586 RF‐2009‐1549251 MULTIMODAL CLINICAL NEUROPHYSIOLOGICAL AND NEUROIMAGING APPROACH TO DISORDERS OF CONSCIOUSNESS IN THE REHABILITATION PHASE 12,5 biomedica Brain Disorders and Clinical Neuroscience € 400.000,00 587 RF‐2009‐1548666 Implementation and optimization of T‐cell therapy for EBV‐related tumors 12,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 500.000,00 588 RF‐2009‐1549214 In vitro and in vivo studies on a new blood component: platelet gel from cord blood 12,5 clinico assistenziale Healthcare Delivery and Methodologies € 594.000,00 589 RF‐2009‐1531265 Atherosclerosis and osteoporosis: identification of common pathogenetic factors. 12,5 clinico assistenziale Vascular and Hematology € 300.000,00 590 RF‐2009‐1544926 Epigenetic markers of melanoma progression 12,5 biomedica Oncology 1 ‐ Basic Translational € 380.000,00 591 RF‐2009‐1539540 Microparticles released from reactive microglia: a potential biomarker for multiple sclerosis and neurodegenerative diseases 12,5 biomedica Brain Disorders and Clinical Neuroscience € 340.000,00 Pagina 51 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 592 RF‐2009‐1544666 Skin lipidoma: an innovative tool to investigate individual vulnerability and repair capacity of photodamaged skin 12,5 biomedica Musculoskeletal, Oral and Skin Sciences € 580.000,00 593 RF‐2009‐1548121 Nutrient(Zinc)‐gene interaction in old patients affected by Chronic Obstructive Pulmonary Disease (COPD) and muscle weakness//hypotrophy (Sarcopenia). 12,5 biomedica Genes, Genomes and Genetics € 600.000,00 594 RF‐2009‐1546273 Development of a microarray‐based diagnostic system for the detection of major bacterial agents of acute respiratory tract infections and antibiotic resistance genes at point‐of‐care 12,5 biomedica Infectious Diseases and Microbiology € 565.000,00 595 RF‐2009‐1538867 Nano‐self‐assembled niosomal aggregates: an innovative multi‐drug delivery system for pulmonary tuberculosis 12,5 biomedica Bioengineering Sciences and Technologies € 500.000,00 596 GR‐2009‐1604482 A LONGITUDINAL STUDY OF NEURAL PLASTICITY IN CHILDREN WITH AUTISM SPECTRUM DISORDERS 12,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 244.000,00 597 GR‐2009‐1607521 CORD BLOOD SERUM EYE DROPS IN THE TREATMENT OF OCULAR SURFACE DISEASES IN GVHD PATIENTS 12,5 biomedica Interdisciplinary Molecular Sciences and Training € 362.010,00 598 GR‐2009‐1591859 Non invasive induction of long‐term synaptic plasticity in the human cerebellum: a new strategy for the rehabilitation of cerebellar disorders. 12,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 597.300,00 599 RF‐2009‐1530862 Metabotropic glutamate receptors and endocannabinoids: functional interactions and physiopathological role in cerebral ischemia 12,5 biomedica Brain Disorders and Clinical Neuroscience € 200.000,00 600 RF‐2009‐1528280 Combination of new biomarkers to predict mortality in elderly patients affected by myocardial infarction 12,5 biomedica Genes, Genomes and Genetics € 494.000,00 601 GR‐2009‐1608394 ALBRIGHT HEREDITARY OSTEODYSTROPHY AND PSEUDOHYPOPARATHYROIDISM: INVESTIGATION ON THE DISRUPTED SIGNALLING UNDERLYING ITS PATHOGENESIS AND IDENTIFICATION OF A NOVEL CLINICAL, BIOCHEMICAL AND MOLECULAR CLASSIFICATION 12,5 clinico assistenziale Genes, Genomes and Genetics € 470.000,00 602 RF‐2009‐1511108 STUDY OF THE MICROENVIRONMENT IN PATIENTS WITH MONOCLONAL GAMMOPATHY: IDENTIFICATION OF NEW MOLECULAR TARGETS 12,5 biomedica Oncology 1 ‐ Basic Translational € 308.000,00 Pagina 52 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto € 290.000,00 603 GR‐2009‐1578825 p140Cap as a tumour suppressor gene in breast cancer: prognostic value and therapeutic approaches 12,5 biomedica Oncology 1 ‐ Basic Translational 604 RF‐2009‐1529635 Adrenal tumors: from molecular studies to clinical application 12,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences 605 GR‐2009‐1600074 Pharmacogenetics in Parkinsons disease treatment: circulating lymphocytes as a novel tool to predict drug efficacy and tolerability 12,5 biomedica Genes, Genomes and Genetics € 390.000,00 606 GR‐2009‐1567604 Development of innovative immunotherapeutic strategies against oligomeric beta amyloid isoforms by intracellular antibody technology 12,5 biomedica Brain Disorders and Clinical Neuroscience € 530.000,00 607 RF‐2009‐1528821 A NEW POTENTIAL THERAPEUTIC TOOL IN FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD): EXPLORING IN VIVO AND IN VITRO SKELETAL MUSCLE DIFFERENTIATION OF AUTOLOGOUS FSHD MESOANGIOBLASTS 12,5 biomedica Musculoskeletal, Oral and Skin Sciences € 319.000,00 608 GR‐2009‐1605046 Melanoma shapes immune cells & stroma microenvironmental components through exosome‐driven transfer of functional molecules 12,5 biomedica Immunology € 237.600,00 609 GR‐2009‐1553658 Mesenchymal Stem Cells Therapy for the treatment of intervertebral disc degeneration: from bench and animal model to bedside 12,5 biomedica Musculoskeletal, Oral and Skin Sciences € 600.000,00 610 RF‐2009‐1504435 Resting state activity and its gabaergic modulation of stimulus‐induced activity in depression: A translational investigation 12,5 biomedica Biobehavioral and Behavioral Processes € 339.600,00 611 GR‐2009‐1567179 Role of Mediterranean Diet and vitamin D in prevention of cognitive decline in subjects with cognitive impairment 12,5 clinico assistenziale Risk, Prevention and Health Behavior € 491.000,00 612 GR‐2009‐1608600 Role of autophagy in the development and prognosis of CNS tumors 12,5 biomedica Cell Biology € 596.200,00 613 RF‐2009‐1527044 Unraveling the immunological mechanisms and molecular correlates of IFN‐alpha plus Ribavirin treatment efficacy for improving disease management in HCV‐ infected patients 12,5 biomedica Immunology € 598.400,00 € 312.700,00 Pagina 53 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 614 GR‐2009‐1606274 Identification and characterization of "cancer stem cells/tumor initiating cells" in chronic lymphocytic leukemia 12,5 biomedica Oncology 1 ‐ Basic Translational € 487.000,00 615 RF‐2009‐1519507 Endocrine evaluation of adult patiens with beta‐thalassemia with particular focus on GH secretion. Effects of rhGH treatment in thalassemic patients with GH deficiency. 12,5 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 355.000,00 616 GR‐2009‐1605472 Revealing Chronic Lymphocytic Leukemia intra‐clonal complexity: a tool for the conceivement of novel highly specific therapeutic approaches and the identification of a Leukemic Stem Cell 12,5 biomedica Oncology 1 ‐ Basic Translational € 502.000,00 617 GR‐2009‐1580416 An analysis of genetic and environmental factors affecting language development in typically developing children and children with Specific Language Impairment 12,5 biomedica Genes, Genomes and Genetics € 403.742,28 618 RF‐2009‐1503886 Striatal synaptic plasticity in experimental models of Parkinsons disease: molecular mechanisms and therapeutics implications 12,5 biomedica Brain Disorders and Clinical Neuroscience € 403.000,00 619 RF‐2009‐1471695 Improving characterization of anti‐leukemia activity mediated by NK cells derived from patients and haploidentical donors of hematopoietic stem cells: molecular interactions, identification of optimal donors, immune evasion mechanisms. 12,5 biomedica Oncology 2 ‐ Translational Clinical € 300.000,00 620 RF‐2009‐1474780 DEFINITION OF AN APPROPRIATE TIME WINDOW IN THE PERI‐NATAL PHASE TO PREVENT ALLERGEN SENSITIZATION: PRECLINICAL STUDY IN PREGNANT AND NEWBORN MICE 12,5 biomedica Immunology € 525.800,00 621 RF‐2009‐1472880 Genetic and biological aspects of familial/sporadic TDP43 proteinopathies 12,5 biomedica Genes, Genomes and Genetics € 590.100,00 622 RF‐2009‐1470902 IDENTIFICATION OF NOVEL THERAPEUTIC AGENTS FOR IMPAIRED SKIN WOUND HEALING IN DIABETES 12,5 biomedica Cardiovascular and Respiratory Sciences € 466.200,00 623 RF‐2009‐1473056 Understanding the WHIM syndrome: molecular analysis of CXCR4 functions in leukocyte trafficking and activation 12,5 biomedica Immunology € 576.000,00 624 RF‐2009‐1470765 Prevalence and impact on total mortality of chronic kidney disease in patients with type 2 diabetes in Apulia; a paradigm for a region‐based study whose data may be specifically implemented in the management of chronic metabolic and vascular diseases in 12,5 clinico assistenziale Population Sciences and Epidemiology € 488.000,00 Pagina 54 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 625 RF‐2009‐1505357 Development and validation of a novel platform of multifunctional fusion proteins for in vivo imaging and therapy of glioblastoma 12,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 600.000,00 626 RF‐2009‐1473182 Integrated high‐throughput approaches to ascertain novel mechanisms of RAS signaling dysregulation in human disease 12,5 biomedica Genes, Genomes and Genetics € 426.000,00 627 RF‐2009‐1472693 The Identification of a Proteomic Signature and Development of new Prognostic Markers and Therapeutic Targets in Chronic Lymphocytic Leukemia 12,5 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 628 RF‐2009‐1491790 Identification of key functional mediators in innate immune cells from subjects naturally controlling HIV infection in the absence of antiretroviral therapy. 12,5 biomedica Immunology € 360.000,00 629 GR‐2009‐1475813 Use of Icg‐loaded erythrocytes for choroidal angiography and retinal laser photocoagulation. 12,5 biomedica Bioengineering Sciences and Technologies € 461.000,00 630 RF‐2009‐1476007 Clinical and biological features of multiple myeloma patients in first relapse following frontline therapy with new drugs 12,5 biomedica Oncology 2 ‐ Translational Clinical € 296.000,00 631 GR‐2009‐1545297 Motor wave propagation in the human spinal cord: normal and pathological gait 12,67 biomedica Integrative, Functional, and Cognitive Neuroscience € 419.980,00 632 GR‐2009‐1607872 From GWAS to high resolution mapping and functional analyses: gaining mechanistic insights with clinical implications into susceptibility to nevus development, malignant melanoma and pancreatic cancer 12,67 biomedica Oncology 1 ‐ Basic Translational € 572.000,00 633 RF‐2009‐1530507 Role of REST, linked to TSC2 and beta‐catenin, in the transformation of medullo and neuroblastomas. 12,67 biomedica Cell Biology € 368.888,00 634 RF‐2009‐1473780 Amplification of the RARA gene in a sub‐population of patients with HER2‐ positive breast carcinoma is associated with sensitivity to retinoic acid and derivatives: from the bench to the bedside and the other way around. 12,67 biomedica Oncology 1 ‐ Basic Translational € 570.000,00 635 RF‐2009‐1472199 PHD fingers in human diseases: structural and functional studies of SP140‐PHD finger 12,67 biomedica Biological Chemistry and Macromolecular Biophysics € 530.000,00 Pagina 55 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 636 RF‐2009‐1538752 Novel molecular markers of thyroid neoplasms 12,75 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 637 RF‐2009‐1536040 HPV as primary screening test in cervical cancer prevention: from DNA to mRNA? A randomised controlled trial nested in a double testing study with long term follow up. 12,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 600.000,00 638 GR‐2009‐1608159 ASSESSMENT OF INDIVIDUAL GENETIC PROFILE IN HEALTHY YOUNG INDIVIDUALS WITH AND WITHOUT FAMILY HISTORY OF PROSTATE CANCER: IMPLICATIONS FOR INDIVIDUALIZED PROSTATE CANCER SCREENING PROGRAMS 12,75 clinico assistenziale Genes, Genomes and Genetics € 410.000,00 639 GR‐2009‐1580943 Transcriptional silencing by zinc‐finger technology to treat gain of function mutations 12,75 biomedica Genes, Genomes and Genetics € 595.000,00 640 GR‐2009‐1580464 PHARMACOKINETIC, PHARMACODYNAMIC AND PHARMACOGENOMIC ASSESSMENTS APPLIED TO THE OPTIMIZATION OF ANTI‐LEUKEMIC THERAPY FOR PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA 12,75 biomedica Oncology 2 ‐ Translational Clinical € 500.000,00 641 GR‐2009‐1580036 Ovarian reserve in women and their reproductive competence 12,75 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 257.000,00 642 RF‐2009‐1549144 Diagnosis and treatment of inflammatory arthropathies in the Regione Emilia‐ Romagna: a prospective population‐based study 12,75 clinico assistenziale Healthcare Delivery and Methodologies € 529.000,00 643 GR‐2009‐1594627 Hypersexuality and pathological gambling associated to Parkinson's disea‐ se: development of preclinical animal models, study of their causes and neuro‐ chemical mechanisms and clinical evaluation of their features and progression 12,75 biomedica Brain Disorders and Clinical Neuroscience € 260.000,00 644 GR‐2009‐1580488 A forecasting model for drug utilization and expenditure integrating a Cellular Automata model with the Budget Impact Analysis approach. 12,75 clinico assistenziale Healthcare Delivery and Methodologies € 535.900,00 645 RF‐2009‐1539267 Early combined ropinirole and rasagiline therapy in newly diagnosed patients with Parkinsons disease. A multicenter prospective randomized follow‐up study including delayed‐start design of rasagiline 12,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 150.000,00 Pagina 56 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 646 RF‐2009‐1527386 Targeting of ALK kinase activity in neuroblastoma 12,75 biomedica Oncology 2 ‐ Translational Clinical € 231.000,00 647 RF‐2009‐1532587 The relationship of psychopathological and immunological changes to coronary heart disease: prospective observational study of subjects experienced April 6th 2009 L'Aquila earthquake 12,75 biomedica Integrative, Functional, and Cognitive Neuroscience € 381.600,00 648 RF‐2009‐1511298 Metabolomic profiling of adult patients with newly diagnosed acute myeloid leukemia (AML) undergoing intensive treatment 12,75 biomedica Biological Chemistry and Macromolecular Biophysics € 540.000,00 649 GR‐2009‐1607326 Phenotypic characterization of parkinsonian syndromes associated with glucosecerebrosidase mutations 12,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 456.500,00 650 GR‐2009‐1573369 Development of a new analytical method for combined determination of the toxins most commonly found in Italian seafood 12,75 biomedica Interdisciplinary Molecular Sciences and Training € 500.000,00 651 RF‐2009‐1536301 SPATIAL‐TEMPORAL INTERACTIONS IN THE BRAIN: CLINICAL/REHABILITATIVE IMPLICATIONS 12,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 352.499,00 652 GR‐2009‐1608377 Diagnosis of cardiovascular disease in the low HDL people: a nanotechnological approach in the identification of blood cell patognomonic features. 12,75 biomedica Cardiovascular and Respiratory Sciences € 416.350,00 653 GR‐2009‐1607368 Role of microRNAs 143 and 145 in cardiovascular physiology and disease: from bench to bedside 12,75 biomedica Vascular and Hematology € 570.000,00 654 GR‐2009‐1570058 ORGANIZATION OF A REGIONAL REFERENCE LABORATORY FOR THE (STANDARDIZATION OF) MOLECULAR MONITORING OF PHILADELPHIA‐ POSITIVE LEUKEMIAS 12,75 clinico assistenziale Vascular and Hematology € 187.000,00 655 GR‐2009‐1608713 HERITABLE DISORDERS OF CONNECTIVE TISSUE: EARLY DETECTION OF AORTIC ANEURYSMS AND PREVENTION OF DISSECTION 12,75 clinico assistenziale Cardiovascular and Respiratory Sciences € 574.000,00 656 RF‐2009‐1538078 The role of hypoxia in regulating microRNAs and target genes in cancer biology: identification of new therapeutic targets 12,75 biomedica Oncology 1 ‐ Basic Translational € 522.500,00 Pagina 57 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 657 GR‐2009‐1575520 A in vivo Study of the Interaction between Lymphocytes, and Antigen‐Presenting Cells in the Pathophysiology of chronic GVHD following Allogeneic Hematopoietic Stem Cell Transplantation 12,75 clinico assistenziale Vascular and Hematology € 255.000,00 658 GR‐2009‐1578342 Prevention of medical device‐related infections by innovative anti‐microbial biofilm polymers 12,75 biomedica Infectious Diseases and Microbiology € 600.000,00 659 GR‐2009‐1493113 GORMITA (Generator Of Response Markers Impacting Targeted Agents): a comprehensive approach for the identification of molecular predictors of response to targeted treatments in soft‐tissue sarcomas 12,75 biomedica Oncology 1 ‐ Basic Translational € 550.000,00 660 RF‐2009‐1485912 Non‐Integrating Lentiviral Vectors for AIDS Vaccine 12,75 biomedica AIDS and Related Research € 575.000,00 661 RF‐2009‐1491198 Mesenchymal stem cell‐derived microvesicles for the treatment of nephropathic cystinosis and other monogenic lysosomal disorders 12,75 biomedica Genes, Genomes and Genetics € 326.150,00 662 RF‐2009‐1499651 Early identification of newborns at high risk of brain injury through a validated biomarkers profile and specific neuro‐imaging patterns. A follow up study of clinical and neurodevelopmental outcome in a large cohort study. 12,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 296.500,00 663 GR‐2009‐1472561 Age related hearing impairment: an innovative, multidisciplinary and International approach to identify genetic and environmental risk factors based on high throughput technologies 12,75 biomedica Genes, Genomes and Genetics € 363.265,00 664 RF‐2009‐1475439 STUDY OF THE WILD‐TYPE SOD1 AGGREGATION IN LYMPHOBLASTS OF SPORADIC ALS PATIENTS TO OPEN NEW PERSPECTIVES IN THE PATHOLOGICAL MECHANISMS 12,75 biomedica Molecular, Cellular, and Developmental Neuroscience € 367.000,00 665 GR‐2009‐1493029 A new rehabilitation approach for Alzheimer's Disease 12,75 biomedica Brain Disorders and Clinical Neuroscience € 594.000,00 666 GR‐2009‐1473829 Determination of kinase inhibitor resistance mechanisms and develoment of novel inhibitor compounds in anaplastic large‐cell lymphoma and melanoma 12,75 biomedica Oncology 2 ‐ Translational Clinical € 215.000,00 667 GR‐2009‐1606866 Profile of inflammatory mediators in patients with psoriasis, and their association with comorbidities. 12,8 biomedica Musculoskeletal, Oral and Skin Sciences € 440.000,00 Pagina 58 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto € 292.600,00 668 RF‐2009‐1530499 Functional approaches for identification of novel targets in thyroid carcinogenesis 12,84 biomedica Oncology 1 ‐ Basic Translational 669 RF‐2009‐1492424 Development and exploitation of a platform able to produce antibody‐based reagents. From monoclonal murine antibody to completely human reagent using protein engineering to raise new potent diagnostic and therapeutic tools in oncology 12,84 biomedica Immunology € 512.000,00 670 RF‐2009‐1519678 Developing of specific, sensitive and non‐invasive diagnostic tests on all saliva for heavy drinker subjects 13 biomedica Risk, Prevention and Health Behavior € 350.000,00 671 GR‐2009‐1606720 Clinical and biological activity of curcumin in patients with psoriasis vulgaris 13 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 206.000,00 672 GR‐2009‐1592038 The activation of GPR35 by Kynurenic acid in the schizophrenia‐associated deficit of glutamatergic transmission 13 biomedica Brain Disorders and Clinical Neuroscience € 164.000,00 673 RF‐2009‐1511297 Tailored Beta‐catenin mutational approach in extra‐abdominal sporadic desmoid tumor patients 13 clinico assistenziale Oncology 2 ‐ Translational Clinical € 419.000,00 674 GR‐2009‐1607315 Human models for identifying biomarkers of cutaneous beta‐HPV infection and the definition of their oncogenic implications 13 biomedica Infectious Diseases and Microbiology € 365.000,00 675 RF‐2009‐1511057 Calcium/Calmodulin‐dependent kinases: novel links between metabolic stress and inflammatory response 13 biomedica Immunology € 510.500,00 676 GR‐2009‐1595860 Gastrointestinal neuropathies induced by neurotropic viruses: innate cellular mechanisms and cell‐based repair in neurodegeneration 13 biomedica Digestive, Kidney and Urological Systems € 549.000,00 677 GR‐2009‐1600623 Analysis of RNA processing defects in amyotrophic lateral sclerosis 13 biomedica Genes, Genomes and Genetics € 601.000,00 678 GR‐2009‐1607416 Identification of a Bcr‐Abl/Hausp network that inactivates the tumor suppressor PTEN in Chronic Myeloid Leukemia 13 biomedica Oncology 1 ‐ Basic Translational € 304.000,00 679 RF‐2009‐1536072 Erasing fear in post traumatic stress disorder: monitoring neuronal connectivity in hippocampal‐cortical networks during reconsolidation or extinction of remote aversive memories 13 clinico assistenziale Brain Disorders and Clinical Neuroscience € 394.000,00 Pagina 59 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 680 GR‐2009‐1601011 TMEM127, the new tumor suppressor gene predisposing to pheochromocytoma 13 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 342.100,00 681 RF‐2009‐1526402 Acinetobacter baumannii colonization/infection in ICU patients: two sides of the coin? 13 clinico assistenziale Infectious Diseases and Microbiology € 355.000,00 682 GR‐2009‐1594693 Identification and functional analysis of mutations in FMR1 and FMRP‐interacting genes CYFIP1 and BC200 in a large cohort of patients with idiopathic mental retardation and/or autism. 13 biomedica Molecular, Cellular, and Developmental Neuroscience € 220.000,00 683 RF‐2009‐1547039 Role of human CYP3A4 and CYP3A5 genetic polymorphisms on the pharmacokinetics of Protease Inhibitor Lopinavir/Ritonavir in HIV‐1 infected subjects 13 clinico assistenziale AIDS and Related Research € 149.800,00 684 GR‐2009‐1592229 Periodontal disease as emergent systemic pathology: development of a new clinical unit for patients global health care 13 clinico assistenziale Healthcare Delivery and Methodologies 685 RF‐2009‐1538519 Targeting tumours with competitive proteins and bi‐functional antibodies to interfere with receptor tyrosine kinase/ beta1 integrin cross‐talk: validation and preclinical studies 13 biomedica Oncology 1 ‐ Basic Translational € 450.000,00 686 GR‐2009‐1606891 Cytokines and antibodies in the treatment of disseminated neuroblastoma: a preclinical study 13 biomedica Oncology 2 ‐ Translational Clinical € 540.000,00 687 GR‐2009‐1510915 Development and characterization of a rat model of alpha‐synuclein‐induced neuronal degeneration: toward a better understanding and treatment of Parkinson´s disease 13 biomedica Brain Disorders and Clinical Neuroscience € 595.000,00 688 GR‐2009‐1510919 MicroRNA regulation by mutant p53 oncoprotein in human cancer. 13 biomedica Oncology 1 ‐ Basic Translational € 370.000,00 689 RF‐2009‐1549101 The microenvironment of classical Hodgkin Lymphoma: the role of MSC in promoting tumor growth, the formation of an immunosuppressive microenvironment, the induction of drug resistance. 13 biomedica Oncology 1 ‐ Basic Translational € 525.555,00 € 511.940,00 Pagina 60 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 690 GR‐2009‐1608080 Therapeutic targeting of the initial steps of the metastatic cascade through RNAi‐ based identification and pre‐clinical validation of components of the "proteoglycan system" 13 biomedica Cell Biology € 586.000,00 691 GR‐2009‐1577482 The morphological and microstructural MRI correlates of motor, cognitive and neurobehavioral impairment in Parkinson disease 13 clinico assistenziale Biobehavioral and Behavioral Processes € 400.000,00 692 GR‐2009‐1608428 Angiogenic and Immunogenic Aspects of Coronary Transplant Arteriosclerosis 13 biomedica Vascular and Hematology € 300.000,00 693 RF‐2009‐1549303 A multicentric study to standardize a new informatic tool to assess cognitive and behavioral functions in acute stroke 13 clinico assistenziale Integrative, Functional, and Cognitive Neuroscience € 574.000,00 694 GR‐2009‐1573896 The Rai adaptor protein in Th17 cell differentiation, effector function and chemotaxis and in the pathogenesis of multiple sclerosis 13 biomedica Immunology € 361.600,00 695 GR‐2009‐1549493 THE ROLE OF MACROPHAGES IN PRIMARY BILIARY CIRRHOSIS 13 biomedica Immunology € 539.000,00 696 RF‐2009‐1547834 A Systems Biology approach to understand Melanoma in the context of the immune response 13 biomedica Immunology € 485.000,00 697 GR‐2009‐1555517 Understanding integrins' role in cancer: energetic and molecular insights into ligand recognition process 13 biomedica Biological Chemistry and Macromolecular Biophysics € 260.000,00 698 RF‐2009‐1527188 Molecular mechanisms linking hypertension and Alzheimer's disease: role of Receptor for Advanced Glycation End‐products (RAGE). 13 biomedica Brain Disorders and Clinical Neuroscience € 595.100,00 699 GR‐2009‐1591087 Study of epigenetic program in heart failure to identify of novel potential therapeutic targets 13 biomedica Cardiovascular and Respiratory Sciences € 583.333,00 700 RF‐2009‐1486739 Genetic regulation of inflammation‐mediated activation of haemostasis 13 biomedica Genes, Genomes and Genetics € 599.000,00 701 RF‐2009‐1471742 Role of mesenchymal stromal cells in lymphoma‐mediated immunosuppression: a novel target for the treatment. 13 biomedica Immunology € 291.200,00 Pagina 61 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 702 RF‐2009‐1486269 innovAtive Device for tRansabdominal relevatIon of fetAl oxygeN sAturation (ADRIANA) 13 biomedica Bioengineering Sciences and Technologies € 539.000,00 703 RF‐2009‐1483534 Characterization of epsins function in endocytosis, epidermal homeostasis and cancer 13 biomedica Oncology 1 ‐ Basic Translational € 480.000,00 704 RF‐2009‐1483266 Can Mesenchymal Stem Cells used as therapeutic agents induce the formation of tumors in the host? 13 biomedica Musculoskeletal, Oral and Skin Sciences 705 RF‐2009‐1483473 Discovery and clinical translation of a factor that rebuilds immunity after bone marrow transplant 13 biomedica Immunology € 360.000,00 706 GR‐2009‐1470114 Dystrophic cardiomyopathy as an investigational model for novel therapeutic approaches 13 biomedica Cardiovascular and Respiratory Sciences € 577.000,00 707 RF‐2009‐1483774 NO‐NSAID for the treatment of cancer 13 biomedica Oncology 1 ‐ Basic Translational € 525.000,00 708 RF‐2009‐1476268 Mechanisms of reactivation of the FMR1 gene and analysis of pathways involved in the pathogenesis of fragile X syndrome: towards a drug‐based therapy. 13 biomedica Genes, Genomes and Genetics € 160.000,00 709 RF‐2009‐1469449 Search of novel therapies for latent tuberculosis 13 biomedica Infectious Diseases and Microbiology € 600.000,00 710 RF‐2009‐1474964 Unlocking tumor immune recognition through self HLA‐E molecules 13 biomedica Immunology € 264.000,00 711 GR‐2009‐1492184 Neoadjuvant targeted agents followed by surgery in squamous cell carcinoma of head and neck: detection of promising agents through identification of molecular and imaging parameters to predict treatment activity and/or resistance 13 clinico assistenziale Oncology 2 ‐ Translational Clinical € 429.000,00 712 RF‐2009‐1493239 Tailored screening for breast cancer in premenopausal women. A translational, randomized, population‐based trial. 13 clinico assistenziale Oncology 2 ‐ Translational Clinical € 600.000,00 713 GR‐2009‐1471987 Systems Biology of von Hippel‐Lindau syndrome 13 biomedica Biological Chemistry and Macromolecular Biophysics € 303.100,00 € 557.700,00 Pagina 62 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 714 RF‐2009‐1492743 Biological and clinical implications of two miRNA clusters potentially associated with lack of clinical response to conventional chemotherapy in advanced stage ovarian carcinomas 13 biomedica Oncology 2 ‐ Translational Clinical € 165.000,00 715 RF‐2009‐1472170 Regulation of histone deacetylase 1 and 2 13 biomedica Cell Biology € 535.500,00 716 RF‐2009‐1502045 Evaluation in elderly patients with urogenital cancer (prostate, kidney, bladder and penis) of the geriatric care needs and pathways after initial treatment. 13 clinico assistenziale Oncology 2 ‐ Translational Clinical € 561.300,00 717 RF‐2009‐1468619 Hepatocyte growth factor as a regulator of indoleamine 2,3‐dioxygenase 1 (IDO1) expression in cancer 13 biomedica Immunology € 571.300,00 718 GR‐2009‐1594595 Longitudinal observational 36‐months prospective study aimed at exploring diagnostic and prognostic salivary proteomic biomarkers for primary Sjögren' s syndrome (pSS) 13,17 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 175.000,00 719 RF‐2009‐1534871 FROM CONFOCAL ENDOSCOPY TO TARGETED ENDOSCOPY FOR EARLY DETECTION AND TREATMENT OF ESOPHAGEAL AND COLONIC NEOPLASTIC LESIONS. 13,17 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering 720 GR‐2009‐1604309 SLEEP‐WAKE DISTURBANCES IN INTERNAL MEDICINE: THE LIVER MODEL 13,17 clinico assistenziale Digestive, Kidney and Urological Systems € 361.935,00 721 RF‐2009‐1472164 Novel therapeutic strategy combining an extracellular matrix‐mediated and cell surface‐based platform for the simultaneous targeting of neovascular elements and tumor cells. 13,17 biomedica Oncology 2 ‐ Translational Clinical € 285.600,00 722 RF‐2009‐1492260 Magnetic resonance imaging with hyperpolarized 13C‐pyruvate for innovative cardiac diagnostic imaging 13,17 biomedica Cardiovascular and Respiratory Sciences € 250.000,00 723 RF‐2009‐1524423 Cardiovascular complication in Familial HDL Deficiency: new diagnostic tools from circulating cell biology 13,25 biomedica Cardiovascular and Respiratory Sciences € 326.650,00 724 RF‐2009‐1530868 Development of scFvs against the HPV16 E6, E7, L1 and L2 proteins for diagnostic, prognostic and therapeutic applications 13,25 biomedica Oncology 2 ‐ Translational Clinical € 335.500,00 725 RF‐2009‐1519531 Genetic study for the diagnosis and treatment of patients with Porphyria. 13,25 clinico assistenziale Genes, Genomes and Genetics € 600.000,00 € 369.600,00 Pagina 63 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 726 GR‐2009‐1578270 Quality of life, cognitive abilities and costs of transcatheter aortic valve implantation and surgical aortic valve replacement 13,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 600.000,00 727 RF‐2009‐1524104 Biomarker‐driven development of 3rd generation anti‐angiogenic cancer therapies 13,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 590.000,00 728 GR‐2009‐1595272 Therapeutical approaches for diabetes due to the proteotoxic effect of misfolded insulin and beta‐cellular ER‐stress 13,25 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 500.000,00 729 GR‐2009‐1607228 From genes to function: statistical and experimental investigation of neurodegenerative mechanisms in Multiple Sclerosis 13,25 biomedica Genes, Genomes and Genetics € 236.200,00 730 GR‐2009‐1605107 Activation of A3 adenosine receptor by Cl‐IB‐MECA in a mouse model of melanoma. 13,25 biomedica Immunology € 463.050,00 731 RF‐2009‐1536545 Predictive factors in endocrine unresponsive breast cancer patients 13,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 380.000,00 732 RF‐2009‐1528730 Preclinical and clinical studies using a new human radiolabeled recombinant monoclonal antibody fragment (scFv anti‐CEA) by PET imaging in the localization of gastric cancers. 13,25 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 733 RF‐2009‐1532150 Molecular events involved in progression from hepatitis C virus (HCV) chronic infection to hepatocellular carcinoma: miRNome and proteome analysis in experimental and clinical settings 13,25 biomedica Infectious Diseases and Microbiology € 589.999,00 734 GR‐2009‐1592201 THE FATE OF MELANOPSIN RETINAL GANGLION CELLS AND PHOTOENTRAINMENT OF CIRCADIAN RHYTHMS IN NEURODEGENERATION 13,25 biomedica Brain Disorders and Clinical Neuroscience € 282.650,00 735 RF‐2009‐1492312 INNOVATIVE STRATEGY ADDRESSED TO TERRITORIAL AND HOSPITAL INTERACTION AT REGIONAL LEVEL FOR IMPROVED MANAGEMENT OF ADVANCED LIVER DISEASE 13,25 clinico assistenziale Digestive, Kidney and Urological Systems € 370.000,00 736 RF‐2009‐1474075 Phenotypic and genetic characterization of ALS: a step towards developing effective therapies 13,25 biomedica Brain Disorders and Clinical Neuroscience € 545.000,00 Pagina 64 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 737 RF‐2009‐1474409 Neurobiology of Fragile X Syndrome: a biochemical and electrophysiological study on developmental pre‐ and post‐synaptic mechanisms. 13,25 biomedica Brain Disorders and Clinical Neuroscience € 403.500,00 738 RF‐2009‐1485959 Novel functions for D‐aspartate in the mammalian brain and its potential involvement in schizophrenia 13,25 biomedica Brain Disorders and Clinical Neuroscience € 486.000,00 739 RF‐2009‐1473856 Understanding the biological continuum between Amyotrophic lateral sclerosis (ALS) and Fronto‐temporal dementia (FTD): a step towards a more efficient assistance model for the affected patients 13,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 591.000,00 740 RF‐2009‐1493197 Hypoxia in neuroblastoma tumors: from the biology to the identification of novel predictors of outcome 13,25 biomedica Oncology 2 ‐ Translational Clinical € 318.600,00 741 GR‐2009‐1606111 Amniotic fluid‐derived mesenchymal stromal cells as potential cellular component for bone repair 13,3 biomedica Musculoskeletal, Oral and Skin Sciences € 542.000,00 742 RF‐2009‐1510996 Role of pro‐angiogenic factors in leukemogenesis and evaluation of the effectiveness of their targeting as anti‐tumor therapy 13,34 biomedica Oncology 1 ‐ Basic Translational € 490.000,00 743 GR‐2009‐1607545 Bisphosphonates and Bones Material Composition 13,34 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 600.000,00 744 RF‐2009‐1532226 ACTIVITY OF METFORMIN ON CELL PROLIFERATION IN PATIENTS WITH EARLY BREAST CANCER 13,34 clinico assistenziale Oncology 2 ‐ Translational Clinical € 448.100,00 745 RF‐2009‐1469465 Innovative adhesives for the treatment of retinal detachment: development and biocompatibility assessment. 13,34 biomedica Bioengineering Sciences and Technologies € 455.000,00 746 GR‐2009‐1523224 EPIGENETIC ROLE OF NITRIC OXIDE IN THE SENESCENCE AND AGING 13,5 biomedica Biology of Development and Aging € 357.500,00 747 RF‐2009‐1531282 Genomic and transcriptional profiling of primary cutaneous B cell lymphoma for the improvement of cancer molecular diagnostic 13,5 biomedica Oncology 2 ‐ Translational Clinical € 331.100,00 748 GR‐2009‐1604878 Therapy based on A2A receptor antagonism in combination with mesenchymal stem cell transplantation in an animal model of stroke 13,5 biomedica Brain Disorders and Clinical Neuroscience € 315.000,00 Pagina 65 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 749 GR‐2009‐1584343 MET‐Inhibitors and MHC‐Unrestricted Adoptive Immunotherapy: Potentials and Synergisms in a Non‐Small‐Cell Lung Cancer Preclinical Model. 13,5 biomedica Oncology 1 ‐ Basic Translational € 196.000,00 750 GR‐2009‐1606828 Calcium‐dependent cell‐cell adhesion molecule dysfunctions associated to mutations of protocadherin 19 (PCDH19) gene (Xq22) in epilepsy. Molecular screening and identification of the causative role of PCDH19 gene in a spectrum of epilepsy phenotypes and g 13,5 biomedica Genes, Genomes and Genetics € 562.320,00 751 GR‐2009‐1512181 New therapeutic approach to Autosomal Dominant Osteopetrosis (ADO) 13,5 biomedica Genes, Genomes and Genetics € 328.350,00 752 RF‐2009‐1530442 MEDications in the ELderly NETwork Acute Care (MEDELNET‐AC) 13,5 clinico assistenziale Healthcare Delivery and Methodologies € 530.000,00 753 RF‐2009‐1511023 Evolution of H1N1 pandemic influenza viruses and its impact on influenza prevention and control 13,5 biomedica Infectious Diseases and Microbiology € 599.500,00 754 RF‐2009‐1539223 Detection of early markers of Bronchiolitis obliterans syndrome (BOS) by proteomic Broncho Alveolar Lavage‐fluid analysis with SELDI‐TOF 13,5 biomedica Cardiovascular and Respiratory Sciences € 150.000,00 755 GR‐2009‐1604462 Innovative Technologies in Mental Retardation Genetics (ITER) 13,5 biomedica Genes, Genomes and Genetics € 309.042,00 756 GR‐2009‐1606220 Leptin and obesity: cellular bases of both cardiovascular and cancer risk. 13,5 biomedica Vascular and Hematology € 445.500,00 757 GR‐2009‐1594499 A novel transgenic swine model of amyotrophic lateral sclerosis (ALS) 13,5 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 758 RF‐2009‐1546281 Clinical impact of ultra high‐field MRI in neurodegenerative diseases diagnosis 13,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 356.375,00 759 GR‐2009‐1591914 Metabolic state and natural regulatory T cells: cellular and molecular basis for a novel immune intervention in multiple sclerosis 13,5 biomedica Immunology 760 GR‐2009‐1591008 Folic acid assumption in late pregnancy and its interaction with parental and fetal genes in childhood asthma development 13,5 biomedica Population Sciences and Epidemiology € 600.000,00 € 185.700,00 Pagina 66 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 761 RF‐2009‐1511538 THE PATHOPHYSIOLOGICAL SUBSTRATES OF RARE DISEASES PRESENTING WITH CORTICAL HYPEREXCITABILITY AND MYOCLONUS: IMPLEMENTATION OF AN INNOVATIVE FUNCTIONAL APPROACH CAPABLE TO ADVISE THE TREATMENT CHOICE 13,5 biomedica Brain Disorders and Clinical Neuroscience € 543.400,00 762 GR‐2009‐1607294 EVALUATION OF CARDIOVASCULAR RISK IN HIV‐POSITIVE PATIENTS UNDER HAART 13,5 clinico assistenziale AIDS and Related Research € 563.700,00 763 RF‐2009‐1524319 A systems biology framework for multiple sclerosis 13,5 biomedica Brain Disorders and Clinical Neuroscience € 429.000,00 764 GR‐2009‐1607498 Mesenchymal progenitor cells as biomarkers in idiopathic pulmonary fibrosis: a prospective study. 13,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 275.000,00 765 GR‐2009‐1596488 The IL‐7/IL‐7 receptor axis as a common, novel target pathway in autoimmunity and cancer 13,5 biomedica Immunology € 354.900,00 766 GR‐2009‐1579861 Characterization of Tertiary Lymphoid Structures in Colorectal Cancer and their clinical relevance 13,5 biomedica Digestive, Kidney and Urological Systems € 471.000,00 767 RF‐2009‐1526401 Effects of overweight/obesity and weight loss on metabolic factors associated with increased cancer risk and DNA damage in monozygotic twin pairs discordant for body weight. 13,5 biomedica Oncology 2 ‐ Translational Clinical € 544.000,00 768 GR‐2009‐1547492 A novel pharmacological approach for the management of spinal cord injury: regulation of NAD pathway 13,5 biomedica Brain Disorders and Clinical Neuroscience € 470.000,00 769 GR‐2009‐1592029 Study of the Causal Relationship between Intestinal Permeability, Microbial Translocation and T Lymphocyte Hyperactivation in HIV‐Infected Patients with Poor Immunological Response in Course of Suppressive HAART 13,5 clinico assistenziale AIDS and Related Research € 228.800,00 770 RF‐2009‐1549220 Functional studies of deregulated microRNAs in Sezary Syndrome 13,5 biomedica Oncology 1 ‐ Basic Translational € 312.000,00 771 GR‐2009‐1580139 HYPERHOMOCYSTEINEMIA AND NEUROLOGICAL DISORDERS: EFFECTS ON METHYLATION STATUS AND THERAPEUTICAL PERSPECTIVES 13,5 biomedica Brain Disorders and Clinical Neuroscience € 343.000,00 772 GR‐2009‐1594504 Systems analysis of mitotic transitions 13,5 biomedica Cell Biology € 526.666,00 Pagina 67 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 773 RF‐2009‐1530991 The hidden androgen deficiency in young men. A role as predictor of metabolic syndrome, sexual dysfunction and cardiovascular disease. 13,5 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 470.000,00 774 RF‐2009‐1537886 RTKs target therapy: toward a prevention of drug resistance 13,5 biomedica Oncology 1 ‐ Basic Translational € 596.200,00 775 GR‐2009‐1528716 Targeting the ERBB‐3 receptor: chimerization and humanization of a murine anti‐ ERBB‐3 antibody. 13,5 biomedica Oncology 2 ‐ Translational Clinical € 431.000,00 776 RF‐2009‐1524340 Metabolomic Profiling of Heart Failure 13,5 biomedica Cardiovascular and Respiratory Sciences € 540.100,00 777 GR‐2009‐1608008 MicroRNA signature in colorectal carcinoma: correlation with mutational status of signaling pathways 13,5 biomedica Oncology 2 ‐ Translational Clinical € 268.000,00 778 RF‐2009‐1509165 REGULATION OF TUMOR DORMANCY BY HETEROTYPIC CELL‐CELL INTERACTIONS: DISSECTING THE MOLECULAR PATHWAYS DOWNSTREAM OF NOTCH FOR THERAPEUTIC PURPOSES 13,5 biomedica Oncology 1 ‐ Basic Translational € 410.000,00 779 RF‐2009‐1549494 New models for in vivo and in vitro analysis of carbon nanotubes: an approach for the evaluation of occupational and environmental risk 13,5 biomedica Risk, Prevention and Health Behavior € 150.000,00 780 RF‐2009‐1472806 Characterization of intestinal mucosal B cells and isolation of HIV neutralizing monoclonal antibodies 13,5 biomedica AIDS and Related Research 781 GR‐2009‐1474179 ADAM10: from neurodevelopment to neurodegeneration 13,5 biomedica Brain Disorders and Clinical Neuroscience € 361.000,00 782 RF‐2009‐1491359 Allogeneic stem cell transplantation in hematological malignancies: conditioning with total lymphoid irradiation and thymoglobulin to reduce complications and increase anti‐tumor effects 13,5 clinico assistenziale Immunology € 150.000,00 783 RF‐2009‐1472163 Therapeutics that target EMT in chemoresistant ovarian cancer: emerging role of endothelin A receptor 13,5 biomedica Oncology 1 ‐ Basic Translational € 326.700,00 784 RF‐2009‐1470581 RESTORING CELL‐ECM INTERACTION TO RESCUE MUSCLE AND NERVE DEGENERATION IN CONGENITAL MUSCULAR DYSTROPHY 13,5 biomedica Musculoskeletal, Oral and Skin Sciences € 525.000,00 € 600.000,00 Pagina 68 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 785 RF‐2009‐1468924 CARDIOTOXICITY OF ANTICANCER DRUGS AND CHEMOPREVENTIVE APPROACHES 13,5 biomedica Cardiovascular and Respiratory Sciences € 246.500,00 786 RF‐2009‐1483545 Development of a stem cell approach for the treatment of TARDP and sporadic Amyotrophic Lateral Sclerosis (ALS stem) 13,5 biomedica Brain Disorders and Clinical Neuroscience € 540.000,00 787 RF‐2009‐1483430 Cancer Stem Cells and Tumor Associated Fibroblasts in Breast cancer: search for new targeted therapy 13,5 biomedica Oncology 1 ‐ Basic Translational € 604.500,00 788 RF‐2009‐1468477 Epigenetics of skin repair 13,5 biomedica Musculoskeletal, Oral and Skin Sciences € 577.000,00 789 RF‐2009‐1475478 Outpatient Day Service (ODS): a technological integrated innovative health care modality for the secondary prevention in subjects with diabetes mellitus 13,5 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 790 RF‐2009‐1488710 Role of the long pentraxin PTX3 in the biology of lymphatic vessels 13,5 biomedica Cell Biology € 600.000,00 791 GR‐2009‐1596815 Improvement of feed quality and safety by using functional agents and novel detection system of toxic agents for the attainment of safe and high quality food of animal origin 13,6 biomedica Veterinary ‐ Food Safety ‐ FOSA € 538.000,00 792 RF‐2009‐1524431 An in vitro ad in vivo imaging approach to myelin dysfunction and reconstruction after stroke: role of GPR17, a new player in the specification of stem‐like neural cells 13,67 biomedica Brain Disorders and Clinical Neuroscience € 528.000,00 793 RF‐2009‐1529511 Electrophysiological investigation of substantia nigra pars reticulata neurons on the functional effects of high frequency stimulation in the subthalamic nucleus: implications for the Deep Brain Stimulation therapy in Parkinsons disease 13,67 biomedica Brain Disorders and Clinical Neuroscience € 350.000,00 794 RF‐2009‐1539347 Impact of neurological aging and cognitive impairment on hospitalization and mortality in an Italian elderly general population cohort 13,67 clinico assistenziale Population Sciences and Epidemiology € 340.000,00 795 RF‐2009‐1548257 An innovative assay development for minimal residual disease detection in adult patients with acute myeloid leukemia based on Surface Enhanced Raman Spectroscopy 13,67 biomedica Bioengineering Sciences and Technologies € 530.000,00 Pagina 69 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 796 RF‐2009‐1470092 NEW INSIGHTS ABOUT BONE METASTATIC NICHE OF HUMAN BREAST CANCER: HEPATOCYTE GROWTH FACTOR/MET SYSTEM ORCHESTRATES THE CROSS‐TALK METASTASIS/MICROENVIRONMENT AND REGULATES GENE EXPRESSION THROUGH betaCATENIN/WNT PATHWAY 13,67 biomedica Oncology 1 ‐ Basic Translational € 171.500,00 797 RF‐2009‐1475107 New insight into thyroid epithelial carcinogenesis: role of oncogene‐induced senescence 13,67 biomedica Oncology 1 ‐ Basic Translational € 481.800,00 798 RF‐2009‐1468554 Clinical implications and emotional impact of electrocardiographic and genetic screening for the risk of sudden death in the young: the case of the long QT syndrome 13,67 clinico assistenziale Cardiovascular and Respiratory Sciences € 597.000,00 799 GR‐2009‐1607195 Multifunctional coated gold nanoparticles as contrast agents for multimodal imaging in neurodegenerative diseases 13,75 biomedica Brain Disorders and Clinical Neuroscience € 560.120,00 800 RF‐2009‐1523355 Tumor micro‐environment as a determinant of outcome to anti‐EGFR and anti‐ VEGF antibodies in advanced colorectal cancer: a comprehensive analysis 13,75 biomedica Oncology 2 ‐ Translational Clinical € 544.600,00 801 RF‐2009‐1539740 Identification of regulatory network of myeloid‐derived suppressor cells by integrating gene expression and microRNA expression data. 13,75 biomedica Genes, Genomes and Genetics € 450.000,00 802 GR‐2009‐1505780 Human Immunoagents for the Therapy of ErbB2‐positive cancer patients ineligible to Herceptin treatment 13,75 biomedica Oncology 2 ‐ Translational Clinical € 440.000,00 803 RF‐2009‐1539464 Randomized phase III trial (OBELICS study) and biomarkers evaluation to optimize the schedule of bevacizumab in combination with chemotherapy in colorectal cancer 13,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 588.700,00 804 RF‐2009‐1547242 Radiotherapy as an immunological booster in patients with metastatic melanoma or renal cell carcinoma treated with High‐dose Interleukin‐2: evaluation of biomarkers of immunologic and therapeutic response 13,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 300.000,00 805 GR‐2009‐1550863 Experimental models of Alzheimer's disease: development of new therapies based on neural plasticity induced by the Rho GTPases' activator CNF1 13,75 biomedica Molecular, Cellular, and Developmental Neuroscience € 525.000,00 806 GR‐2009‐1605547 Antiplatelet therapy tailored by platelet function and pharmacogenetic profile: towards an appropriate use of the new antiplatelet agents 13,75 clinico assistenziale Vascular and Hematology € 181.500,00 Pagina 70 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 807 GR‐2009‐1521736 Pharmacogenomic Approach to Personalize and Optimize the Available Drug‐ therapy for Alzheimer's Disease 13,75 biomedica Genes, Genomes and Genetics € 597.850,00 808 GR‐2009‐1555845 A new gene for inherited thrombocytopenias: clinical, pathogenetic and pharmacological studies 13,75 biomedica Vascular and Hematology € 400.000,00 809 RF‐2009‐1549450 Assessment of different behaviors of non‐adherence to antiretroviral therapy as predictors of viro‐immunological and clinical outcome of HIV infection during the last HAART era. 13,75 clinico assistenziale AIDS and Related Research € 246.000,00 810 RF‐2009‐1546664 Peritoneal Mesothelioma: Optimize Outcomes by the Integration of new Prognostic Factors and Potential Therapeutic Targets in a Individualized Treatment based on Molecular Characterization and Chemosensitivity Profile on Primary Cultures. 13,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 525.800,00 811 GR‐2009‐1519806 Predictivity for MPN of screening for JAK2 V617F and TET2 mutations in asymptomatic patients with splanchnic thrombosis and usefulness in clinical management and counselling. 13,75 clinico assistenziale Vascular and Hematology € 350.000,00 812 RF‐2009‐1532564 Molecular profiles in Male Breast Cancer (MBC) 13,75 biomedica Oncology 1 ‐ Basic Translational € 500.000,00 813 GR‐2009‐1525606 New immunotherapeutic strategies in pancreatic cancer: pre‐clinical validation of DNA vaccination with alpha‐enolase. 13,75 biomedica Oncology 2 ‐ Translational Clinical € 492.025,00 814 RF‐2009‐1548820 Mechanism‐based biomarkers in oncology therapy: Evaluation of biochemical and cellular markers as surrogate endpoints for predicting response to neoadjuvant anti‐EGFR therapy with cetuximab in head and neck cancer patients 13,75 biomedica Oncology 2 ‐ Translational Clinical € 421.250,00 815 RF‐2009‐1547476 Unraveling neurobiology of social anhedonia as a core dimension of Deficit Schizophrenia 13,75 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 816 RF‐2009‐1491589 Methods for investments/disinvestments and distribution of health technologies in Italian Regions ‐ MIDDIR 13,75 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 817 RF‐2009‐1492993 Involvement of ALK receptor as critical oncogene and tractable target for pediatric rhabdomyosarcoma. 13,75 biomedica Oncology 2 ‐ Translational Clinical € 205.260,00 Pagina 71 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 818 GR‐2009‐1576321 FoxO3A meets the mitochondrial genome: may the ultimate newcomer smooth the way toward mitochondrial medicine? 13,84 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 566.907,00 819 RF‐2009‐1547181 Narcolepsy with cataplexy: a model disease for the study of metabolic syndrome determinants 13,84 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 0,00 820 GR‐2009‐1594705 Three‐dimensional (3D) rendering of left ventricular wall structure (viable myocardium, scar, fat) based on Magnetic Resonance or Multi‐Detector‐ Computed‐Tomography cardiac imaging as anatomic substrate for electroanatomic mapping and radiofrequency ablat 13,84 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 225.000,00 821 GR‐2009‐1608705 ROLE OF MEMBRANE LIPID MICRODOMAINS, RAFTS AND CAVEOLAE, IN THE SIGNALLING OF GROWTH FACTOR RECEPTOR INVOLVED IN THYROID CANCER 13,84 biomedica Cell Biology € 179.000,00 822 RF‐2009‐1473099 Neuronal nicotinic acetylcholine receptors as target to enhance inhibitory neurotransmission in temporal lobe epilepsy. 13,84 biomedica Molecular, Cellular, and Developmental Neuroscience € 324.444,00 823 RF‐2009‐1504694 Early deprogramming to prevent long‐term metabolic consequences of intrauterine growth retardation. A nutritional and hormonal approach. 13,84 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 421.300,00 824 RF‐2009‐1475183 TRANSFORMING GROWTH FACTOR BETA 1 IN THE PATHOPHYSIOLOGY OF HUNTINGTON DISEASE 13,84 biomedica Brain Disorders and Clinical Neuroscience € 340.000,00 825 RF‐2009‐1468068 The role of autophagy in modulating tumor cell response to targeted agents in relapsed/refractory Hodgkin lymphoma (HL) 13,84 biomedica Oncology 1 ‐ Basic Translational € 597.000,00 826 RF‐2009‐1549337 Continuity of care for persons with HIV/AIDS through home and hospice care: a multicentric study to identify barriers to access in the late HAART era 14 clinico assistenziale Healthcare Delivery and Methodologies € 215.000,00 827 RF‐2009‐1549872 CONGESTIVE HEART FAILURE IN INTERNAL MEDICINE SETTING: DIFFERENCE BY GENDER IN QUALITY OF LIFE, PREDICTION OF SURVIVAL AND HOSPITALIZATION 14 clinico assistenziale Cardiovascular and Respiratory Sciences € 225.000,00 Pagina 72 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 828 GR‐2009‐1553705 Study of progression of clinical and neuroimaging features in early‐stage parkinsonism: The role of Diffusion‐weighted Imaging and FDG‐PET in predicting diagnosis of atypical parkinsonian syndromes 14 clinico assistenziale Brain Disorders and Clinical Neuroscience € 385.000,00 829 RF‐2009‐1550115 INTENSIVE ADJUVANT CHEMOTHERAPY REGIMEN 14 clinico assistenziale Oncology 2 ‐ Translational Clinical € 220.000,00 830 RF‐2009‐1550117 Impact of atherosclerosis and hemodynamic markers detected by ultrasound on the outcome of patients with mild degree of carotid stenosis. 14 clinico assistenziale Risk, Prevention and Health Behavior € 465.000,00 831 RF‐2009‐1539840 Mechanisms of cardiomyocyte dysfunction in Fabry disease and susceptibility to long term enzyme replacement therapy 14 clinico assistenziale Cardiovascular and Respiratory Sciences € 453.500,00 832 GR‐2009‐1573934 AUTOPHAGY A NOVEL POTENTIAL TARGET IN DUCHENNE MUSCULAR DYSTROPHY: IDENTIFICATION OF THE PATHWAYS AND NEW PHARMACOLOGICAL STRATEGIES 14 biomedica Musculoskeletal, Oral and Skin Sciences € 411.480,00 833 GR‐2009‐1608797 The role for the GnRH receptor in urinary bladder function 14 biomedica Digestive, Kidney and Urological Systems € 387.750,00 834 RF‐2009‐1539821 Studying and targeting host‐parasite membrane dynamics in malaria parasite blood development 14 biomedica Infectious Diseases and Microbiology € 600.000,00 835 RF‐2009‐1538907 Analysis of the molecular lesions involved in the development of rhabdomyosarcoma in a murine model. New targets for immunoprevention and therapy 14 biomedica Oncology 1 ‐ Basic Translational € 180.000,00 836 GR‐2009‐1608374 Development of new therapies for L‐DOPA‐induced dyskinesia: role of striatal D1R/D3R heterodimeric complex 14 biomedica Molecular, Cellular, and Developmental Neuroscience € 199.000,00 837 RF‐2009‐1549175 Validation and application of a biomolecular method for Escherichia coli O157, Salmonella spp. and Listeria monocytogenes examination in raw ovine milk. 14 biomedica Veterinary ‐ Food Safety ‐ FOSA € 220.000,00 838 GR‐2009‐1607223 Tobacco Control: Econometric Analysis and Public Health Implications 14 clinico assistenziale Risk, Prevention and Health Behavior € 554.000,00 839 GR‐2009‐1606974 Klotho as a regulator of cardiovascular disease progression in patients with chronic kidney disease. 14 biomedica Cardiovascular and Respiratory Sciences € 511.000,00 Pagina 73 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 840 GR‐2009‐1603120 Role of the glycoprotein Dickkopf‐3 in the development of cerebral ischemia and ischemic neuronal death 14 biomedica Brain Disorders and Clinical Neuroscience € 300.000,00 841 RF‐2009‐1545954 Prevalence and risk factors of genital Chlamydia trachomatis infection among sexually active young women (14‐25 years), in Italy 14 clinico assistenziale Population Sciences and Epidemiology € 510.000,00 842 GR‐2009‐1600978 Surgical resection associated with hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal component of gastric and colo‐rectal cancers 14 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 533.333,00 843 RF‐2009‐1546597 MiRNA in diagnosis and experimental therapy of pleural malignant mesothelioma. 14 biomedica Oncology 2 ‐ Translational Clinical € 470.800,00 844 RF‐2009‐1539658 Self‐performed bandaging in the maintenance phase of breast cancer related lymphedema : advantages of patient's self‐management 14 clinico assistenziale Risk, Prevention and Health Behavior € 164.580,00 845 RF‐2009‐1546511 GENERATION AND IMPLEMENTATION OF A SHARED SYSTEM OF MONITORING, WARNING AND RESPONSE TO ACUTE CLINICAL EVENTS IN PATIENTS HOSPITALIZED IN INTERNAL MEDICINE UNITS 14 clinico assistenziale Healthcare Delivery and Methodologies € 254.000,00 846 GR‐2009‐1575595 Focus on Myotonic Dystrophy pathogenesis and MBNL1 proteins: expression, signalling and modulation in DM1 mice models 14 biomedica Genes, Genomes and Genetics € 301.900,00 847 GR‐2009‐1607806 THE LOW SALT COMMUNITY. A strategy‐testing and feasibility trial of salt reduction at the population level 14 clinico assistenziale Healthcare Delivery and Methodologies € 147.500,00 848 RF‐2009‐1548915 USE OF ‐2PROPSA FOR THE DETECTION OF PROSTATE CANCER IN PATIENTS WHO ARE CANDIDATES FOR A PROSTATE BIOPSY 14 clinico assistenziale Digestive, Kidney and Urological Systems € 520.000,00 849 GR‐2009‐1607221 Arrhythmogenic Right Ventricular Cardiomyopathy: in vivo experimental models for investigating the molecular pathogenesis and identifying new targets for therapy. 14 biomedica Cardiovascular and Respiratory Sciences € 354.000,00 850 GR‐2009‐1608265 Extracellular adenosine triphosphate (eATP) as a pharmacological target in inflammatory muscle myopathies and in muscular dystrophies 14 biomedica Immunology € 494.000,00 851 RF‐2009‐1548704 Identification and monitoring of gene mutations in peripheral blood and urine as a diagnostic tool for patients with solid tumors 14 clinico assistenziale Oncology 2 ‐ Translational Clinical € 377.300,00 Pagina 74 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 852 RF‐2009‐1549398 Combined Phosphodiesterase Inhibitor‐statin therapy in rat and mouse models of Huntingtons disease 14 biomedica Brain Disorders and Clinical Neuroscience € 130.000,00 853 GR‐2009‐1577386 Th17 responses in Cystic Fibrosis: paving the way for novel anti‐inflammatory strategies and immunogenetic screening 14 biomedica Cardiovascular and Respiratory Sciences € 322.402,00 854 RF‐2009‐1546514 THE METABOLIC SYNDROME IN BREAST CANCER SURVIVORS: FROM CLINICAL EPIDEMIOLOGY TO MOLECULAR INVESTIGATION 14 biomedica Oncology 2 ‐ Translational Clinical € 525.000,00 855 RF‐2009‐1524414 Breast Stem Cells and Chemioresistence:Epigenetic Studies 14 biomedica Oncology 1 ‐ Basic Translational € 578.333,00 856 RF‐2009‐1511624 AMP‐DEPENDENT KINASE/MAMMALIAN TARGET OF RAPAMYCIN COMPLEX1 SIGNALING IN T‐CELL ACUTE LYMPHOBLASTIC LEUKEMIA: IMPLICATIONS FOR TARGETED THERAPY 14 biomedica Oncology 1 ‐ Basic Translational € 390.400,00 857 RF‐2009‐1532760 Safety and Appropriateness of Growth Hormone therapy in Italy 14 clinico assistenziale Population Sciences and Epidemiology € 300.000,00 858 RF‐2009‐1531410 New genomic disorders: identification, phenotypic outline and clinical management 14 clinico assistenziale Genes, Genomes and Genetics € 120.000,00 859 GR‐2009‐1526502 Assessment of fetal exposure to alcohol, drugs of abuse and tobacco by biomarkers detection in neonatal meconium 14 clinico assistenziale Biobehavioral and Behavioral Processes € 550.000,00 860 RF‐2009‐1505652 Candida vaginitis and coinfections with Chlamydia trachomatis and Human Papillomavirus: impact on pathogenesis, diagnosis prevention and therapy of these diseases 14 biomedica Infectious Diseases and Microbiology 861 GR‐2009‐1526406 Anti‐cancer blockers of ErbB2 induce oxidative stress and myocardial dysfunction, countered by PDE5‐inhibition, and by enhancement of myocytes Ca2+ cycling and myofilaments Ca2+ sensitivity. 14 biomedica Cardiovascular and Respiratory Sciences € 512.000,00 862 RF‐2009‐1528285 Adolescents and young adults cancers: the burden in Italy 14 clinico assistenziale Population Sciences and Epidemiology € 401.500,00 € 511.500,00 Pagina 75 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 863 RF‐2009‐1511491 The Therapeutics Effects of Sport Activity on Disabled People Brain Functions: Neuro‐Plastic Processes Revealed by the Combination of Electrophysiological and Neuroimaging techniques 14 biomedica Integrative, Functional, and Cognitive Neuroscience € 285.000,00 864 RF‐2009‐1505848 ANTI‐INFLAMMATORY ACTIVITY OF POLYPHENOLS IN CANCER CHEMOPREVENTION 14 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 576.000,00 865 RF‐2009‐1526393 Phase I adoptive immunotherapy study using the anti‐EGFR monoclonal antibody, cetuximab, low dose IL‐2 and allogenic NK cell infusion after immunosuppressive therapy in non‐transplanted patients with metastatic colorectal‐cancer 14 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 866 RF‐2009‐1511618 Chemokine decoy receptors as new pharmacological targets: the D6 case‐of‐study 14 biomedica Immunology € 375.000,00 867 RF‐2009‐1524111 HIV associated neurocognitive disorders in the HAART era: epidemiology, neuropathogenesis, clinical features, treatment responses and impact on health services 14 clinico assistenziale AIDS and Related Research € 123.000,00 868 GR‐2009‐1509191 Investigating the molecular pathology of advanced colorectal cancer: coupling peptide signatures of the liver metastasis microenvironment with KRAS/BRAF mutational status for the design of alternative target therapies 14 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 869 GR‐2009‐1531782 Optimization of the treatment in Non Small Lung Cancer: Impact of different types of K‐RAS mutations on tumour progression and drug sensitivity 14 biomedica Oncology 2 ‐ Translational Clinical € 528.000,00 870 RF‐2009‐1521690 High‐order social cognition in chronic neurological disorders 14 clinico assistenziale Brain Disorders and Clinical Neuroscience € 388.300,00 871 RF‐2009‐1527087 STDs (sexual transmitted diseases) in a vulnerable population: a inmates cohort in Italy 14 clinico assistenziale AIDS and Related Research € 600.000,00 872 RF‐2009‐1521815 Towards "All Laser" procedures in ophthalmic surgery ‐ TALL 14 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 250.000,00 Pagina 76 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 873 RF‐2009‐1511593 VENOUS THROMBOEMBOLISM IN KINDREDS WITH INHERITED THROMBOPHILIA: STRATIFICATION OF THE RISK IN THE CARRIER RELATIVES ACCORDING TO THE CLINICAL PHENOTYPE OF THE PROBAND. IMPLICATIONS FOR FAMILIAL LABORATORY SCREENING OF INDIVIDUALS WITH INHERITED THROMBOPH 14 clinico assistenziale Population Sciences and Epidemiology € 187.000,00 874 RF‐2009‐1528977 Identification of an inflammatory signature of human colorectal cancer to seek candidate molecules as potential prognostic markers and/or therapeutic targets 14 biomedica Digestive, Kidney and Urological Systems € 506.000,00 875 RF‐2009‐1524024 Vitamin B1 analogue benfotiamine for prevention of diabetic cardiomyopathy 14 biomedica Cardiovascular and Respiratory Sciences € 202.000,00 876 RF‐2009‐1510889 Cells and molecules of the innate immunity: potential molecular targets in diagnosis and therapy in cancer 14 biomedica Immunology € 600.000,00 877 RF‐2009‐1529289 Autophagy in the pathogenesis of Gaucher's disease. 14 biomedica Genes, Genomes and Genetics € 264.000,00 878 RF‐2009‐1510967 ANDROGEN DEPRIVATION THERAPY WITHDRAWAL VERSUS MAINTENANCE AND INTERMITTENT DOCETAXEL THERAPY VERSUS CONTINUOUS ADMINISTRATION IN HORMONE REFRACTORY PROSTATE CANCER PATIENTS. A PHASE III STUDY. 14 clinico assistenziale Oncology 2 ‐ Translational Clinical € 168.000,00 879 RF‐2009‐1491786 The role of SOD1 in nucleus: new insights in the pathogenesis of sporadic ALS 14 biomedica Molecular, Cellular, and Developmental Neuroscience € 420.980,00 880 RF‐2009‐1474812 Innovative phase Ib clinical trials based on patient genotype 14 biomedica Oncology 2 ‐ Translational Clinical € 263.000,00 881 RF‐2009‐1505031 Improving specificity of brain iron mapping for the study of physiological and pathological aging 14 biomedica Brain Disorders and Clinical Neuroscience € 388.000,00 882 RF‐2009‐1490934 Identification of progression markers for a clinical impact in cutaneous metastatic melanoma 14 biomedica Oncology 2 ‐ Translational Clinical € 265.650,00 883 RF‐2009‐1504216 Defining the role of the Erk8 MAP kinase in thyroid cancer 14 biomedica Oncology 1 ‐ Basic Translational € 420.500,00 Pagina 77 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 884 RF‐2009‐1485993 Radiation exposure of paediatric patients undergoing interventional radiology procedures 14 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering 885 RF‐2009‐1501930 MECHANISMS OF ENPP1‐MEDIATED MODULATION OF INSULIN ACTION AND SECRETION 14 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 330.000,00 886 RF‐2009‐1473073 The role of unconventional Myosin VI in prostate cancer 14 biomedica Oncology 1 ‐ Basic Translational € 350.000,00 887 GR‐2009‐1492190 The DNA damage response at telomeres: new aspects of a barrier against genomic instability and tumorigenesis. 14 biomedica Oncology 1 ‐ Basic Translational € 552.200,00 888 RF‐2009‐1472874 Epigenetics of cerebral tumors: in vitro studies and perspective clinical applications 14 biomedica Oncology 1 ‐ Basic Translational € 350.000,00 889 RF‐2009‐1475361 Amniotic Fluid Stem Cells (AFS): molecular markers of osteoblastic and neurogenic differentiation and preclinical investigations for the treatment of age‐ related diseases. 14 biomedica Biology of Development and Aging € 596.000,00 890 RF‐2009‐1491710 West Nile virus infection: Pathogenic mechanisms and development of new therapeutic tools 14 biomedica Infectious Diseases and Microbiology € 590.000,00 891 RF‐2009‐1472694 MODELING AND THERAPEUTIC TARGETING OF THE IDH1 MUTATION IN GLIOMAS 14 biomedica Oncology 1 ‐ Basic Translational € 569.800,00 892 RF‐2009‐1493182 BIOMARKERS FOR TUBERCULOSIS 14 biomedica Infectious Diseases and Microbiology € 600.000,00 893 RF‐2009‐1474439 The Ligurian Palliative Care Demonstration Project 14 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 894 RF‐2009‐1474055 Host and microbial biomarkers in exhalate breath condensate and other accessible body fluids for Clinical and incipient tuberculosis detection 14 biomedica Immunology € 600.000,00 895 RF‐2009‐1473499 Characterization of BRCA1 transcriptional regulation by Next generation sequencing 14 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 € 533.273,00 Pagina 78 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 14 biomedica Cell Biology € 200.000,00 Dissecting host‐parasite interactions by RNA interference (RNAi) knock‐down of lipid raft proteins in human erythrocytes 14,1 biomedica Infectious Diseases and Microbiology € 600.000,00 898 GR‐2009‐1538035 Role of Twist1 transcription factor in thyroid tumor progression 14,13 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 899 GR‐2009‐1605747 MULTITHERAPEUTIC APPROACH TO THE SPINAL CORD INJURY BY SMART HYDROGEL DRUG DELIVERY 14,17 biomedica Brain Disorders and Clinical Neuroscience 900 RF‐2009‐1539292 Identification of new genetic factors of non medullary familial thyroid carcinoma and study of their interaction with the phenotype 14,17 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 901 RF‐2009‐1483567 Italian Network on Hereditary Periodic Fevers: ITALIANFEVER 14,17 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 902 RF‐2009‐1475344 Prenylcysteine lyase, a novel pro‐oxidant low density lipoprotein‐associated protein: from biology to its role in atherosclerosis 14,2 biomedica Vascular and Hematology € 577.778,00 903 GR‐2009‐1584537 Development and validation of a novel brain imaging method for the in vivo assessment of distinct patterns of connectivity disorders of consciousness 14,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 482.000,00 904 RF‐2009‐1523737 Identification of new molecular targets in biliary carcinoma 14,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 450.000,00 905 GR‐2009‐1608871 The neurobiology of working memory span in normal and pathological ageing 14,25 biomedica Brain Disorders and Clinical Neuroscience € 543.560,00 906 RF‐2009‐1539197 Induced Pluripotent Stem Cells and Exploration of Reprogramming Epigenetic Molecules for neurodegenerative disease 14,25 biomedica Emerging Technologies and Training in Neurosciences € 270.000,00 907 GR‐2009‐1535328 A randomized controlled trial of metabolic intervention in breast cancer families 14,25 clinico assistenziale Risk, Prevention and Health Behavior € 343.200,00 908 GR‐2009‐1600791 Identification of a novel prognostic operator‐independent methodology for the individualized assessment of lung water and fibrosis 14,25 biomedica Bioengineering Sciences and Technologies € 168.500,00 896 RF‐2009‐1472691 OSTEOGENIC DIFFERENTIATION OF HUMAN ADIPOSE TISSUE‐DERIVED STEM CELLS: INVOLVEMENT OF EPIGENETIC MECHANISMS 897 GR‐2009‐1592083 € 522.223,00 Pagina 79 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 909 GR‐2009‐1539288 IDENTIFICATION OF PREDICTIVE BIOMARKERS FOR MULTIPLE MYELOMA AT FIRST RELAPSE 14,25 biomedica Oncology 2 ‐ Translational Clinical € 402.000,00 910 RF‐2009‐1530653 GENETIC CONTRIBUTION TO INHIBITORS DEVELOPMENT IN HEMOPHILIA A 14,25 clinico assistenziale Vascular and Hematology € 195.000,00 911 RF‐2009‐1511460 The potential of miRNome screening for understanding the clinical response and the mechanism of action of SSRI antidepressant drugs 14,25 biomedica Biobehavioral and Behavioral Processes € 600.000,00 912 GR‐2009‐1580289 Targeting Biomarkers of Glaucoma in the Trabecular Meshwork: understanding Pathophysiology to Point Towards New Diagnostic and Therapeutic Strategies for Glaucoma 14,25 biomedica Brain Disorders and Clinical Neuroscience € 388.000,00 913 GR‐2009‐1606497 EFFECTS OF BOTULINUM TOXIN A INJECTION IN THE DETRUSOR MUSCLE AND HIGH‐FREQUENCY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION OVER FRONTAL AREAS IN PATIENTS WITH NEUROGENIC OVERACTIVE BLADDER SYNDROME DUE TO PARKINSONS DISEASE AND MULTIPLE SCLEROSIS: INS 14,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 349.000,00 914 RF‐2009‐1474537 Implementation of a novel mechatronic paradigm for management, rehabilitation and restoration of motor functioning in patients with disorders of consciousness 14,25 clinico assistenziale Emerging Technologies and Training in Neurosciences € 572.222,50 915 RF‐2009‐1474341 Optimization of human oocytes vitrification procedure through the randomized clinical application of an open protocol versus a closed protocol 14,25 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 446.600,00 916 RF‐2009‐1469155 PARKINSONS DISEASE AS A MULTIFACTORIAL DISORDER: CLINICAL AND PRE‐CLINICAL INVESTIGATION OF POTENTIAL BIOMARKERS FOR RISK ASSESSMENT AND MONITORING OF DISEASE PROGRESSION AND COMPLICATIONS OF LONG‐TERM L‐DOPA THERAPY 14,25 biomedica Brain Disorders and Clinical Neuroscience € 480.700,00 917 RF‐2009‐1504260 Target enrichment and massively parallel sequencing to discover the cause of Schwannomatosis, a rare mendelian disorder. 14,25 biomedica Genes, Genomes and Genetics € 600.000,00 918 RF‐2009‐1486287 Assessment of the allergic risk in the newborn and development of clinical practice guidelines for risk monitoring and allergy management. 14,25 biomedica Risk, Prevention and Health Behavior € 325.000,00 Pagina 80 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 919 GR‐2009‐1472225 Assessment of an adaptive response in patients with thyroid diseases after iodine‐ 131 metabolic therapy 14,25 biomedica Oncology 2 ‐ Translational Clinical € 363.000,00 920 RF‐2009‐1502221 Role of Copy Number variations in determining the individual susceptibility to essential hypertension 14,25 biomedica Cardiovascular and Respiratory Sciences € 515.900,00 921 GR‐2009‐1605748 Relevance of host factors in the pathogenesis of HCV‐related lymphoproliferative disorders 14,3 biomedica Oncology 1 ‐ Basic Translational € 205.000,00 922 RF‐2009‐1547286 Cancer pain classification in palliative care. Clinical and genetic determinants of comprehensive management outcome 14,34 clinico assistenziale Oncology 2 ‐ Translational Clinical € 580.800,00 923 GR‐2009‐1569530 The neural architecture of temporal processing 14,34 biomedica Biobehavioral and Behavioral Processes € 360.000,00 924 RF‐2009‐1510990 Study of the involvement of mutant p53 gain of function in tumor microenvironment 14,34 biomedica Oncology 1 ‐ Basic Translational € 270.000,00 925 GR‐2009‐1530057 Attentional selection under alcohol consumption: Psychophysical and neural correlates of attention impairment 14,34 biomedica Biobehavioral and Behavioral Processes € 254.000,00 926 GR‐2009‐1568956 Arachidonic acid‐activated Ca2+ channel as potential target for tumor angiogenesis interference 14,38 biomedica Oncology 1 ‐ Basic Translational € 300.000,00 927 GR‐2009‐1528657 Prognostic role of follow up in melanoma patients. A prospective, randomized, trial. 14,5 clinico assistenziale Healthcare Delivery and Methodologies € 320.000,00 928 RF‐2009‐1543766 Adaptation, operation and analysis of the biological effects on tumour cellular models of photoneutron converters (BNCT) at clinical LINAC's with real‐time neutron dosimetry. 14,5 biomedica Oncology 1 ‐ Basic Translational € 287.000,00 929 RF‐2009‐1536209 A comprehensive treatment for locally advanced breast cancer patients according to different biological features 14,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 299.200,00 930 RF‐2009‐1548147 General practice vs specialist‐based follow‐up for patients with colon cancer: a randomised controlled trial 14,5 clinico assistenziale Population Sciences and Epidemiology € 387.000,00 Pagina 81 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 931 GR‐2009‐1580309 Prognostic value of cross‐sectional and long‐term changes of grey matter structure and functional reorganization for physical disability and cognitive impairment in people with Multiple Sclerosis 14,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 460.000,00 932 RF‐2009‐1534804 Ultrasound in physical therapy: a clinical and economical evaluation 14,5 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 566.000,00 933 RF‐2009‐1510965 A novel approach to understanding the role of mTOR in immunity and cancer 14,5 biomedica Immunology € 345.000,00 934 RF‐2009‐1532745 Design of novel rational therapeutic strategies for RET‐driven medullary thyroid carcinoma 14,5 biomedica Oncology 1 ‐ Basic Translational € 567.600,00 935 GR‐2009‐1583872 Predictors of sleepiness related accidents in sleep disorders with excessive daytime sleepiness: from a laboratory‐based driving simulator approach to real road accident risk. 14,5 clinico assistenziale Risk, Prevention and Health Behavior € 215.000,00 936 GR‐2009‐1584439 An open source, platform independent, WEB‐based implementation of IHE radiological and nuclear medicine workflow. 14,5 biomedica Healthcare Delivery and Methodologies € 300.000,00 937 GR‐2009‐1584396 MATCH: Multidisciplinary Approach to brain Tumours in CHildhood 14,5 clinico assistenziale Population Sciences and Epidemiology € 245.300,00 938 GR‐2009‐1591576 Relevance of Toll‐like Receptor 9 in lung carcinoma 14,5 biomedica Immunology € 450.450,00 939 RF‐2009‐1524704 TM9SF4 A NEW PROTEIN ASSOCIATED TO THE METASTATIC PHENOTYPE OF HUMAN MELANOMA. A POTENTIAL NEW TARGET FOR ANTI‐CANCER STRATEGIES 14,5 biomedica Oncology 1 ‐ Basic Translational € 500.000,00 940 GR‐2009‐1525569 A simple method for estimating global DNA methylation using micro fluidic device with single nucleotide resolution 14,5 biomedica Bioengineering Sciences and Technologies € 410.300,00 941 GR‐2009‐1606098 Interplay between PGE‐2 and HIF‐1 alpha in tumor progression and angiogenesis. 14,5 biomedica Oncology 2 ‐ Translational Clinical € 356.500,00 942 GR‐2009‐1543834 A different vasopressor approach during cardiopulmonary resuscitation: evaluating the effects of administration of the short acting beta‐1 adrenergic blocker agent, esmolol, in combination with epinephrine, on outcome of cardiac arrest. From the experimen 14,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 248.050,00 Pagina 82 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 943 RF‐2009‐1537954 Prevention of peripartum, postnatal and breastfeeding‐HIV transmission in pregnant HIV‐infected women treated with HAART in the uran and rural areas of Dodoma ‐ Tanzania 14,5 clinico assistenziale AIDS and Related Research 944 GR‐2009‐1604480 Role of Notch in neuroplasticity : implication for cerebral palsy neurorehabilitation 14,5 biomedica Brain Disorders and Clinical Neuroscience € 200.000,00 945 GR‐2009‐1594577 An Innovative Biotech Approach to Reduce Parkinson's Disease Neurodegeneration by Hydrogel‐assisted Delivery of Autologous Engineered Fibroblasts 14,5 biomedica Emerging Technologies and Training in Neurosciences € 544.200,00 946 GR‐2009‐1608519 EFFECT OF FLUTICASONE FUROATE ON THE IL‐23/TH17 AXIS IN CHRONIC RHINOSINUSITIS 14,5 biomedica Immunology 947 GR‐2009‐1608558 Motor and autonomic phenotypes associated with GRN and MAPT mutations in frontotemporal lobar degeneration 14,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 384.450,00 948 RF‐2009‐1530779 Proteomic analysis of the saliva: a new tool for diagnosis and classification of rheumatoid arthritis and early rheumatoid arthritis 14,5 biomedica Biological Chemistry and Macromolecular Biophysics € 300.000,00 949 RF‐2009‐1551346 ASSESSMENT OF PRESCRIBING APPROPRIATENESS IN GENERAL PRACTICE AND EVALUATION OF THE IMPACT OF EDUCATION AMONG PRACTITIONERS 14,5 clinico assistenziale Population Sciences and Epidemiology € 234.000,00 950 GR‐2009‐1567012 A new approach for drug resistant epilepsy 14,5 biomedica Brain Disorders and Clinical Neuroscience € 380.000,00 951 RF‐2009‐1549595 Poligenic prediction of ischemic events after early‐onset myocardial infarction. 14,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 189.000,00 952 RF‐2009‐1531133 Novel strategies to deliver a bioactive molecule with antiproliferative properties to prostate cancer cells: melatonin in nanoparticles and as cryo‐laser therapy 14,5 biomedica Oncology 2 ‐ Translational Clinical € 350.000,00 953 GR‐2009‐1568719 A new approach to study alcoholism: evaluation of toxicity, tolerance and ethanol dependence mechanisms by molecular imaging, regulation of transcription and epigenetic analysis 14,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 373.082,00 € 211.900,00 € 173.512,00 Pagina 83 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 954 GR‐2009‐1579815 FREEZING OF GAIT IN PARKINSONS DISEASE: FUNCTIONAL NEUROIMAGING, NEUROPHYSIOLOGICAL and PHARMALCOLOGICAL STUDY 14,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 285.000,00 955 RF‐2009‐1549307 Adolescents and Young Adults Area Project. A dedicated unit for teenagers and young adult with cancer: towards a new clinical and translational research approach 14,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 450.000,00 956 GR‐2009‐1573217 Combined MR and PET imaging for monitoring stem cell therapies 14,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 600.000,00 957 GR‐2009‐1569913 SLEEP DEPRIVATION, SLEEP DISORDERS, FATIGUE, STRESS AND THE RISK OF OCCUPATIONAL INJURIES AND ERRORS AMONG HEALTH‐CARE WORKERS: A MULTI‐APPROACH EPIDEMIOLOGICAL STUDY 14,5 clinico assistenziale Risk, Prevention and Health Behavior 958 RF‐2009‐1548861 Peptides from proteins of innate and adaptive immunity as new therapeutic agents against respiratory pathogens. 14,5 biomedica Infectious Diseases and Microbiology € 550.000,00 959 GR‐2009‐1607756 Evaluation of the effectiveness of a multifactorial approach based on Intermittent Photic Stimulation, Cognitive and Physical Training and pharmacological treatment on slowing the progression of mild Alzheimers Disease, identified in accordance with the 14,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 427.380,00 960 GR‐2009‐1578244 A multimodal approach to disorders of consciousness: integrating neurophysiological signal processing and functional neuroimaging 14,5 biomedica Brain Disorders and Clinical Neuroscience € 272.800,00 961 RF‐2009‐1548346 Colonoscopy based on Actively Propelled and Steerable capsULE (CAPSULE): design, development and preclinical assessment of a novel device for truly endoscopic colorectal cancer screening and diagnosis. 14,5 biomedica Digestive, Kidney and Urological Systems € 595.000,00 962 GR‐2009‐1580030 Defining the intrinsic role of NF‐kappaB canonical signaling in chondrocytes in OA disease onset and progression in an inducible, IKKbeta‐deleter mouse model 14,5 biomedica Musculoskeletal, Oral and Skin Sciences € 544.300,00 963 RF‐2009‐1509084 Characterization of cancer stem cells heterogeneity in human glioblastomas 14,5 biomedica Oncology 1 ‐ Basic Translational € 570.900,00 € 150.150,00 Pagina 84 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 964 GR‐2009‐1578856 DNA Methylation Abnormalities in Blood Cells of Schizophrenic Patients with history of suicide attempts: Identification of epigenetic marks of schizophrenia and suicide risk for diagnostic purposes and prediction of drug responsiveness 14,5 biomedica Brain Disorders and Clinical Neuroscience € 330.000,00 965 RF‐2009‐1472967 Molecular mechanisms underlying organic acidurias identified in newborn screening 14,5 biomedica Genes, Genomes and Genetics € 438.000,00 966 GR‐2009‐1473880 MicroRNAs as predictive biomarkers target in rare paediatric tumors 14,5 biomedica Oncology 2 ‐ Translational Clinical € 599.500,00 967 RF‐2009‐1475586 Autologous dendritic cells immuno‐therapy in HIV positive patients: a genomic approach 14,5 biomedica AIDS and Related Research € 200.000,00 968 RF‐2009‐1471456 Vaccine against Staphylococcus aureus implant‐related infections (VASARI) 14,5 biomedica Immunology € 450.000,00 969 RF‐2009‐1475492 Improving diagnosis and management of patients with cerebellar ataxias by a comprehensive molecular screening of the known genetic forms, a systematic phenotypic classification of sporadic cases, and search for new disease genes in undefined familial case 14,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 393.000,00 970 RF‐2009‐1491734 Molecular signatures in liver lesions as paradigm for discovery of new biomarkers and therapeutic targets 14,5 biomedica Oncology 2 ‐ Translational Clinical € 524.000,00 971 RF‐2009‐1472372 CLINICAL, NEUROIMAGING AND MOLECULAR STUDIES BY NEXT GENERATION SEQUENCING OF MIDLINE BRAIN ABNORMALITIES ASSOCIATED WITH PITUTARY HORMONE DEFICIENCIES: A MULTI‐ DISCIPLINARY NETWORK 14,5 clinico assistenziale Genes, Genomes and Genetics € 600.000,00 972 RF‐2009‐1501035 IDENTIFICATION OF GENETIC DETERMINANTS OF STROKE IN AN ANIMAL MODEL OF A COMPLEX HUMAN DISEASE 14,5 biomedica Genes, Genomes and Genetics € 184.600,00 973 RF‐2009‐1472890 Impact of Antiretroviral Therapy on Viral Replication and Immune Restoration in the Gut‐associated Lymphoid Tissue of HIV‐infected Patients. 14,5 clinico assistenziale AIDS and Related Research € 583.333,00 974 RF‐2009‐1504978 Molecular Phenotyping of Chronic Obstructive Pulmonary Disease. 14,5 biomedica Cardiovascular and Respiratory Sciences € 599.999,00 Pagina 85 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto € 410.000,00 975 RF‐2009‐1504418 Development, in vitro testing and in vivo validation of novel drugs targeting the interaction between the urokinase receptor and the extracellular matrix protein vitronectin: exploiting a novel avenue for the interference with tumor growth, invasion and m 14,5 biomedica Oncology 1 ‐ Basic Translational 976 RF‐2009‐1471993 Oxidative DNA damage and protection of neurodegeneration by the hMTH1 hydrolase: therapeutic approaches in cellular and animal models 14,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 551.100,00 977 RF‐2009‐1504262 DEVELOPMENT AND VALIDATION OF A WIRELESS POLYGRAPHIC DEVICE FOR REMOTELY ATTENDED HOME MONITORING AND DIAGNOSIS OF SLEEP DISORDERS 14,5 clinico assistenziale Emerging Technologies and Training in Neurosciences € 425.500,00 978 RF‐2009‐1493097 Mechanisms of neurodegeneration and phenotypic heterogeneity in inherited prion diseases: physiopathological involvement of prion proteins in membrane trafficking and signaling 14,5 biomedica Brain Disorders and Clinical Neuroscience € 500.000,00 979 RF‐2009‐1469484 From humans to mice and return: comparative analysis among patients and NCL's mouse models 14,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 539.500,00 980 RF‐2009‐1529969 Novel BNCT Clinical Approach to Osteosarcoma 14,67 clinico assistenziale Oncology 2 ‐ Translational Clinical € 595.000,00 981 RF‐2009‐1475727 IKKalpha as a novel therapeutical target in osteoarthritis 14,67 biomedica Musculoskeletal, Oral and Skin Sciences € 599.500,00 982 RF‐2009‐1543604 Significant predictors of risk behaviours and mental health outcomes in adolescent immigrants to Italy compared to a national sample of native Italians 14,75 clinico assistenziale Risk, Prevention and Health Behavior € 264.800,00 983 RF‐2009‐1510966 Prognostic role of circulating tumor cells in stage I‐III colorectal cancer 14,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 560.000,00 984 GR‐2009‐1596748 Predict and Prevent Reading Acquisition Disorders: Developmental and Cognitive Neuroscience of Dyslexia 14,75 biomedica Biobehavioral and Behavioral Processes € 501.000,00 985 GR‐2009‐1605287 Genetic and psychosocial determinants of the outcome of Bipolar depression. 14,75 biomedica Brain Disorders and Clinical Neuroscience € 350.000,00 Pagina 86 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 986 RF‐2009‐1538890 GENETIC PREDISPOSITION AND MECHANISMS OF INTESTINAL FIBROSIS IN CROHNS DISEASE: BASIS FOR THERAPEUTIC AND DIAGNOSTIC INTERVENTION 14,75 clinico assistenziale Genes, Genomes and Genetics € 345.000,00 987 GR‐2009‐1606711 Early cardiac dysfunction predictive of clinically significant Trastuzumab induced cardiac damage in the neoadjuvant, adjuvant and metastatic setting and its correlation with biological markers of chronic inflammation and oxidative stress. Proposal of a c 14,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 185.000,00 988 RF‐2009‐1512210 Phosphorylated alpha‐enolase isoforms as diagnostic and prognostic tools in pancreatic cancer 14,75 biomedica Oncology 2 ‐ Translational Clinical € 219.500,00 989 GR‐2009‐1567138 Exploring immune gene regulation by microRNAs in multiple sclerosis: from candidate to modifier genes 14,75 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 990 RF‐2009‐1545222 Autoimmune pancreatitis mimicking pancreatic cancer: pathogenetic mechanisms and serological markers. 14,75 biomedica Immunology € 263.000,00 991 RF‐2009‐1549217 How hepatitis C virus exploits the lipoproteins machinery: development of new antiviral strategies. 14,75 biomedica Infectious Diseases and Microbiology € 333.000,00 992 GR‐2009‐1604106 EARLIEST ANTENATAL DIAGNOSIS OF GENETIC DISEASES AND CHROMOSOMAL ABNORMALITIES BY COELOMIC FLUID SAMPLING 14,75 biomedica Healthcare Delivery and Methodologies € 500.000,00 993 GR‐2009‐1578069 MicroRNA profile in blood as novel biomarker in Amyotrophic Lateral Sclerosis 14,75 biomedica Brain Disorders and Clinical Neuroscience € 315.000,00 994 GR‐2009‐1601123 Phase II study of neoadjuvant Cisplatin, Gemcitabine plus Sorafenib for transitional cell carcinoma of the bladder. 14,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 290.400,00 995 RF‐2009‐1548925 Dietary fat, inflammatory status and breast cancer risk in the ORDET (Hormones and Diet in Etiology of Tumors) prospective cohort 14,75 clinico assistenziale Population Sciences and Epidemiology € 255.200,00 996 RF‐2009‐1546896 Circulating biomarkers for the diagnosis, prognostic stratification and assessment of response to treatment in hepatocellular and cholangiocellular carcinomas 14,75 biomedica Oncology 2 ‐ Translational Clinical € 540.000,00 997 GR‐2009‐1604422 Definition of new biomarkers and methodologies for the evaluation of the quality of aging: a biomedical, genetic and statistic multidisciplinary approach 14,75 biomedica Genes, Genomes and Genetics € 372.500,00 Pagina 87 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 998 GR‐2009‐1547287 Analysis of ribavirin plasma concentration: evaluation of the possible role in predicting virological responses and in monitoring toxicity in patients with chronic hepatitis C 14,75 clinico assistenziale Infectious Diseases and Microbiology € 198.000,00 999 RF‐2009‐1544967 Study on target therapies Impact in breast cancer patients on a wide area of northern Emilia (AVEN ) Population included in the Reggio Emilia, Modena, Parma, Piacenza Tumour Registry 14,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 420.000,00 1000 RF‐2009‐1547548 Prevention and management of symptom burden in cancer patients: from biological pathways to behavioral interventions 14,75 clinico assistenziale Risk, Prevention and Health Behavior € 600.000,00 1001 GR‐2009‐1607860 Identification of candidate modifier and disease‐causing genes for Multiple Osteochondromas by genome‐wide SNP/CNV genotyping 14,75 biomedica Genes, Genomes and Genetics € 480.700,00 1002 RF‐2009‐1521636 Development of a multigene classifier for the prediction of the response to Metformin of HER2 negative metastatic breast cancer patients based on the expression of genes of the insulin/IGF pathway in circulating tumor cells 14,75 biomedica Oncology 2 ‐ Translational Clinical € 350.000,00 1003 RF‐2009‐1530022 HPV genotyping and evaluation of viral and cancer biomarkers for the triage of anal HPV related lesions in HIV/HPV coinfected patients 14,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 200.000,00 1004 GR‐2009‐1606783 The p53 network in breast cancer aggressiveness: new regulatory levels and molecular targets for diagnosis and therapy. 14,75 biomedica Oncology 1 ‐ Basic Translational € 593.640,00 1005 RF‐2009‐1539240 High‐resolution mapping of genomic structural variation in the general Italian population 14,75 biomedica Genes, Genomes and Genetics € 599.700,00 1006 RF‐2009‐1485922 Nuclear Activation of the Innate Immune Kinase PKR as a Potential Therapeutic Target and Marker for Disease Progression and Therapeutic Response in Myelodysplastic Syndromes and Acute Leukemia 14,75 biomedica Vascular and Hematology € 420.000,00 1007 RF‐2009‐1474995 Individualisation and optimization of antidepressant therapy: from the genetic to clinical observation. 14,75 clinico assistenziale Emerging Technologies and Training in Neurosciences € 580.000,00 1008 GR‐2009‐1493879 Biomarkers of cardiovascular risk and inflammation: potential association with Alzheimer's disease progression and subsequent conversion of mild cognitive impairment to dementia 14,75 biomedica Genes, Genomes and Genetics € 481.000,00 Pagina 88 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1009 RF‐2009‐1486261 Cisplatin, Docetaxel and Capecitabine Followed by Cetuximab and Radiotherapy in Locally Advanced Inoperable Head and Neck Cancer. A Phase I/II Study with Prognostic Evaluation of Biological Parameters. 14,75 biomedica Oncology 2 ‐ Translational Clinical € 360.325,00 1010 GR‐2009‐1491467 A study of defensins and innate immunity genes as candidate genetic factors for HPV infection and HPV‐related cancer development 14,75 biomedica Genes, Genomes and Genetics € 338.000,00 1011 RF‐2009‐1538791 Molecular epidemiology of male breast cancer in Tuscany: genetic alterations and environmental factors 14,84 biomedica Oncology 1 ‐ Basic Translational € 289.300,00 1012 GR‐2009‐1578739 Advanced strategies for maternal and fetal medicine: analysis of fetal nucleic acids in maternal plasma for noninvasive prenatal diagnosis of fetal genetic diseases and monitoring of pregnancy complications 14,84 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 383.000,00 1013 RF‐2009‐1539461 USE OF NATURAL PEPTIDES AS ANTIBACTERIAL AGENTS IN FOOD PRESERVATION 14,84 biomedica Veterinary ‐ Food Safety ‐ FOSA € 500.000,00 1014 RF‐2009‐1539552 EXPERIMENTATION OF LICENSED BONE MARROW DERIVED MESENCHYMAL STROMAL CELLS (MSCs) IN INTRACTABLE AUTOIMMUNE DISORDERS OF CHILDHOOD: A PIVOTAL TRIAL 14,84 biomedica Immunology € 265.000,00 1015 RF‐2009‐1471801 Novel molecular biomarkers predictive of individual response to therapy in human colorectal carcinoma 14,84 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 1016 RF‐2009‐1526361 MicroRNA as modulators of gene expression during beta‐cell damage and regeneration: towards a novel therapeutic tool for cell therapy in diabetes mellitus 15 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 588.500,00 1017 RF‐2009‐1548541 Base excision repair as a therapeutic target in human cancer 15 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 1018 GR‐2009‐1595212 Cognitive and neural plasticity in aging: Behavioral and neurophysiological approaches in memory training 15 biomedica Biobehavioral and Behavioral Processes € 296.000,00 1019 RF‐2009‐1524026 Autism: clinical and genetic correlation in a regional‐based study 15 biomedica Brain Disorders and Clinical Neuroscience € 411.000,00 Pagina 89 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1020 GR‐2009‐1591877 Role of MYC in orchestrating epigenetic events in Embryonic and Cancer Stem Cells 15 biomedica Genes, Genomes and Genetics 1021 GR‐2009‐1600984 EXPLOITING DIFFERENTIATION AND APOPTOSIS TO FIGHT AGAINST THE HETEROGENEITY OF BREAST CANCER. 15 biomedica Oncology 1 ‐ Basic Translational 1022 GR‐2009‐1600983 PULSED ELECTROMAGNETIC FIELD (PEMF) AS ADJUVANT TREATMENT FOR OSTEOCHONDRAL TISSUE REGENERATION OF THE KNEE: FROM PRECLINICAL STUDY TO CLINICAL APPLICATION. 15 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 435.500,00 1023 RF‐2009‐1550476 Constitutive activation of multiple receptor tyrosine kinases in a subset of human melanomas: identification of common and specific intracellular pathways for therapeutic intervention 15 biomedica Oncology 1 ‐ Basic Translational € 251.900,00 1024 GR‐2009‐1536519 Novel inhibitors targeting entry of herpes virus type 1 15 biomedica Infectious Diseases and Microbiology € 500.000,00 1025 GR‐2009‐1600733 Dreaming as a model for psychosis: EEG measurements across states of the brain/mind 15 clinico assistenziale Brain Disorders and Clinical Neuroscience € 348.000,00 1026 RF‐2009‐1521677 Endocrine disrupters and effects on thyroid function: bridging toxicology and clinical endocrinology to characterize mechanisms, biomarkers and potential risks for health, growth and development (EDUCT) 15 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 600.000,00 1027 RF‐2009‐1547453 IMPACT OF AN INTEGRATED REHABILITATION PROGRAM FOR HEAD AND NECK CANCER PATIENTS ON QUALITY OF LIFE, PATIENT‐REPORTED AND FUNCTIONAL OUTCOMES 15 clinico assistenziale Healthcare Delivery and Methodologies € 300.000,00 1028 RF‐2009‐1549712 Suicide Prevention in Italian Regions 15 clinico assistenziale Risk, Prevention and Health Behavior € 460.000,00 1029 RF‐2009‐1532553 Arterial calcification in chronic kidney disease: diagnosis, development and cardiovascular complications 15 clinico assistenziale Vascular and Hematology € 550.000,00 1030 RF‐2009‐1530626 MESENCHYMAL STEM CELL FROM PLACENTA:IMMUNOMODULATION PROPRIETES AND CLINICAL USE 15 biomedica Immunology € 300.000,00 € 200.000,00 € 511.100,00 Pagina 90 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1031 RF‐2009‐1532554 Novel multi‐scale approach to 3D cancer models for the discovery of new therapeutic strategies for patients with bone metastatic lesions 15 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 1032 GR‐2009‐1578373 Cognitive and imaging correlates of brain Abeta amyloidosis in healthy adults 15 clinico assistenziale Brain Disorders and Clinical Neuroscience € 598.240,00 1033 GR‐2009‐1545984 Involvement of microRNAs in breast cancer driving pathways: from biology to possible therapies. 15 biomedica Oncology 1 ‐ Basic Translational € 347.600,00 1034 GR‐2009‐1568011 Genomic instability in healthy tissues after cancer radiotherapy: implications for long term effects 15 biomedica Oncology 2 ‐ Translational Clinical € 514.256,00 1035 GR‐2009‐1594635 Impaired Cardiac Metabolism during Heart Faliure: Role of the Beta 2 Adrenergic Receptor 15 biomedica Cardiovascular and Respiratory Sciences € 545.900,00 1036 GR‐2009‐1594646 TelMedOb ‐ Low‐cost TeleMedicine solutions for the treatment of Obesity with and without Type 2 Diabetes in out‐patient settings 15 clinico assistenziale Risk, Prevention and Health Behavior € 250.000,00 1037 GR‐2009‐1578111 Multifunctional nanocarriers for drug delivery, cellular and molecular imaging as potential therapeutic and diagnostic tools for pediatric tumors 15 biomedica Bioengineering Sciences and Technologies € 600.000,00 1038 RF‐2009‐1525619 A strategy for the implementation of Patient Tailored Chronochemotherapy 15 clinico assistenziale Oncology 1 ‐ Basic Translational € 600.000,00 1039 RF‐2009‐1525745 Efficacy and effectiveness of early and intensive rehabilitation interventions in patients with recent stroke. A randomized controlled study 15 clinico assistenziale Brain Disorders and Clinical Neuroscience € 330.000,00 1040 RF‐2009‐1550779 A research project on management methodologies, which will help improving diagnosis, treatment and scientific research in oncology through an integrated network connecting the Sardinian territory to national IRCCS 15 clinico assistenziale Healthcare Delivery and Methodologies € 565.000,00 1041 GR‐2009‐1594743 Adoptive Immunotherapy with Cytokine‐Induced Killer Cells for the Treatment of Bone sarcomas: Preclinical Model and Clinical Application 15 biomedica Oncology 2 ‐ Translational Clinical € 300.000,00 1042 RF‐2009‐1525310 Ultrasound susceptibility of botulinum neurotoxins and botulinum neurotoxin‐ producing clostridia 15 biomedica Veterinary ‐ Food Safety ‐ FOSA € 594.000,00 1043 GR‐2009‐1595717 Role of OX40L triggering on mast cell functions 15 biomedica Immunology € 596.700,00 Pagina 91 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1044 GR‐2009‐1580563 Integromic analysis of the DNA damage repair networks in patients affected by rectal cancer undergoing neo‐adjuvant treatment with capecitabine and ionizing radiation 15 biomedica Oncology 1 ‐ Basic Translational € 720.000,00 1045 GR‐2009‐1580024 MicroRNA control of prostate cancer metastasis 15 biomedica Oncology 1 ‐ Basic Translational € 402.600,00 1046 GR‐2009‐1595399 Genetic of Major depressive disorder 15 biomedica Genes, Genomes and Genetics € 412.485,00 1047 RF‐2009‐1550219 Neuropeptides and Neprilysin involvement in pancreatic cancer: from pain pathogenesis to cancer progression 15 biomedica Oncology 1 ‐ Basic Translational € 327.000,00 1048 GR‐2009‐1583760 Molecular Mechanisms in Invasive Thyroid Tumors 15 biomedica Oncology 1 ‐ Basic Translational € 379.000,00 1049 RF‐2009‐1529583 Incidence of the histotypes and related variants of thyroid cancer in Western Emilia, including the provinces of Parma, Piacenza, and Reggio Emilia, 2000‐2008. 15 clinico assistenziale Oncology 2 ‐ Translational Clinical € 166.000,00 1050 RF‐2009‐1523605 Hypoxia and Danger signals in Erdheim‐Chester Disease microenvironment: insights on the pathogenesis and implications for therapy 15 biomedica Immunology € 229.000,00 1051 RF‐2009‐1528426 Identification of prognostic and therapeutic biomarkers in patients with high‐risk musculoskeletal sarcomas by profiling post‐transcriptional and post‐translational molecular networks. 15 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 1052 RF‐2009‐1531034 Mechanisms and sources of infection in the main food‐borne zoonoses pathogens and definition of innovative methodologies for human disease prevention, through the implementation of a surveillance network. 15 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 1053 RF‐2009‐1551260 Late Presentation of HIV‐Infected Individuals: Evaluation of Epidemiological, Clinical And Immunological Implications in Order to Optimize Treatment Outcome. 15 clinico assistenziale AIDS and Related Research € 342.400,00 1054 GR‐2009‐1607229 Lung ultrasound for diagnosis, follow‐up and prognosis of cardiopulmonary disease 15 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 231.000,00 Pagina 92 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1055 GR‐2009‐1605292 New strategies for treatment of meningococcal meningitis: therapeutic effects of L‐ glutamate analogues in animal models 15 biomedica Infectious Diseases and Microbiology € 270.000,00 1056 RF‐2009‐1509159 Phosphatonins role in bone mineralization process 15 biomedica Genes, Genomes and Genetics € 222.850,00 1057 GR‐2009‐1607338 Identifying expression dysregulation associated with autism 15 biomedica Genes, Genomes and Genetics € 584.100,00 1058 GR‐2009‐1606589 Isolation and characterization of invasive E coli strains and analysis of their influence on innate immune response in pediatric patients with inflammatory bowel disease 15 biomedica Digestive, Kidney and Urological Systems € 440.000,00 1059 RF‐2009‐1539649 Non traditional vascular, metabolic and inflammatory predictors of silent coronary artery disease and of cardiovascular events in type 2 diabetes mellitus: potential impact on guidelines. 15 clinico assistenziale Cardiovascular and Respiratory Sciences € 437.000,00 1060 GR‐2009‐1607389 Role of Cyclophilin D in tumorigenesis 15 biomedica Oncology 1 ‐ Basic Translational € 421.600,00 1061 RF‐2009‐1539628 Discovery Proteomic Analysis of Human Ovarian Cancer Stem Cells and Functional Validation of Targets 15 biomedica Oncology 2 ‐ Translational Clinical € 588.500,00 1062 GR‐2009‐1605294 'Cancers of unknown primary origin' (CUPs): a pathology driven by the Met oncogene 15 biomedica Oncology 1 ‐ Basic Translational € 448.000,00 1063 GR‐2009‐1536551 Post‐Genome Wide Association study: biological and prognostic significance of alcohol dehydrogenase gene polymorphisms in head and neck cancer patients 15 biomedica Population Sciences and Epidemiology € 332.000,00 1064 GR‐2009‐1607307 Targeting strategies in Numb‐defective cancers 15 biomedica Oncology 1 ‐ Basic Translational € 581.600,00 1065 GR‐2009‐1546218 Environmental influence on motor learning in disability conditions 15 clinico assistenziale Brain Disorders and Clinical Neuroscience € 381.000,00 1066 GR‐2009‐1605609 A novel link between complement and thrombosis promotes cardiovascular events in type 2 diabetes 15 biomedica Vascular and Hematology € 325.000,00 Pagina 93 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1067 RF‐2009‐1543661 Stathmin expression and ovarian carcinoma: searching for a new prognosis marker and new therapeutic approaches. 15 biomedica Oncology 1 ‐ Basic Translational € 227.800,00 1068 RF‐2009‐1511452 Characterization of proteome alterations induced by Mycobacterium tuberculosis in human dendritic cells to develop new TB vaccination strategies. 15 biomedica Immunology € 447.778,00 1069 RF‐2009‐1537808 Characterization of the mechanisms regulating mononuclear phagocyte protumoral activity within the tumor hypoxic microenvironment: potential therapeutic applications 15 biomedica Oncology 1 ‐ Basic Translational € 232.200,00 1070 GR‐2009‐1606739 New immunopahtological‐based diagnostic and therapeutic strategies in dermatitis herpetiformis and celiac disease 15 biomedica Musculoskeletal, Oral and Skin Sciences € 404.000,00 1071 RF‐2009‐1511165 Rapid diagnosis and molecular characterization of B. pertussis infection: relationship with epidemiology, vaccine efficacy, and clinical presentation 15 biomedica Infectious Diseases and Microbiology € 378.400,00 1072 GR‐2009‐1606299 SEARCH FOR BEST CRITERIA TO PREDICT ARRHYTHMOGENIC RISK IN CARDIOMYOPATHIES CAUSED BY MUTATIONS OF GENES CODING DESMOSOME PROTEINS 15 clinico assistenziale Cardiovascular and Respiratory Sciences € 403.000,00 1073 RF‐2009‐1539624 FATTY ACIDS COMPLEMENTATION FOR THE TREATMENT OF SCHIZOPRENIA (FACTS): A DOUBLE‐BLIND, RANDOMIZED CONTROLLED TRIAL 15 clinico assistenziale Biobehavioral and Behavioral Processes € 530.000,00 1074 GR‐2009‐1605514 Establishment and Characterization of cytotoxic T‐lymphocytes for immunotherapy of JC‐virus Associated Progressive Multifocal Leukoencephalopathy 15 biomedica Immunology € 420.000,00 1075 GR‐2009‐1608969 The role of beta‐catenin in T cell‐mediated inflammatory and neurodegenerative processes. 15 biomedica Brain Disorders and Clinical Neuroscience € 445.200,00 1076 RF‐2009‐1538033 Investigation of Norovirus strains with putative zoonotic potential in pet animals in Italy. Implementation of diagnostic assays, molecular characterization and phylogenesis, host restricted binding. 15 biomedica Veterinary ‐ Animal Health ‐ ANHE € 577.000,00 1077 GR‐2009‐1608628 Lymphatic endothelial dysfunction is involved in the pathogenesis of systemic sclerosis 15 biomedica Vascular and Hematology € 506.000,00 Pagina 94 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1078 GR‐2009‐1608708 Dissecting the metastatic process: identification of novel biomarkers improving clinical management of aggressive cancers. 15 biomedica Oncology 1 ‐ Basic Translational € 321.000,00 1079 GR‐2009‐1605045 Monitoring of heart failure: a new non‐invasive method 15 biomedica Cardiovascular and Respiratory Sciences € 535.000,00 1080 GR‐2009‐1605539 Exploring the Autophagy pathway in Amyotrophic Lateral Sclerosis‐related Motor Neuron death 15 biomedica Brain Disorders and Clinical Neuroscience € 528.000,00 1081 RF‐2009‐1509185 Generation and development of monoclonal antibodies recognising tumor stem cells in colorectal and lung cancer 15 biomedica Oncology 2 ‐ Translational Clinical € 172.700,00 1082 RF‐2009‐1539523 Knowledge dissemination as a basis for health promotion and prevention in chronic conditions: focus on cardiovascular health 15 clinico assistenziale Risk, Prevention and Health Behavior € 590.000,00 1083 RF‐2009‐1505448 Guided bone regeneration with innovative degradable scaffolds: preclinical evaluation 15 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 305.000,00 1084 GR‐2009‐1607879 Innate immunity and autoimmunity in myasthenia gravis: outcomes of Epstein‐ Barr virus infection and Toll‐like receptor signaling pathways in B cell function 15 biomedica Immunology € 458.865,00 1085 RF‐2009‐1538322 High‐throughput genomic profiling of autistic patients grouped on the basis of biochemical differences 15 biomedica Genes, Genomes and Genetics € 254.000,00 1086 RF‐2009‐1545193 Exploitation of the sublingual route of immunization for mucosal vaccine against HIV‐1. 15 biomedica AIDS and Related Research € 300.000,00 1087 GR‐2009‐1607921 How to evaluate Efficacy In the framework of cost‐effectiveness analysis for Growth Hormone (rhGH) Therapy in paediatric patients with Growth Hormone deficiency (HEIGHT) 15 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 200.000,00 1088 RF‐2009‐1475519 KIR/HLA phenotypes and genotypes in HIV‐infected elite natural controller subjects and comparative analysis of molecular mechanisms of innate immune responses. 15 biomedica AIDS and Related Research € 198.000,00 1089 RF‐2009‐1483651 Identification of novel synthetic and natural compounds for the development of new drugs targeting vector‐borne protozoan parasites 15 biomedica Infectious Diseases and Microbiology € 592.234,50 Pagina 95 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1090 RF‐2009‐1504018 Enlightening activation of the ocular albinism type 1 protein (OA1) on intracellular organelles by protein complementation assays and correlative light‐electron microscopy 15 biomedica Cell Biology € 462.000,00 1091 RF‐2009‐1486790 The clinical impact of genetic predictors on the treatment of drug‐resistant epilepsy in tuberous sclerosis complex 15 biomedica Genes, Genomes and Genetics € 285.500,00 1092 RF‐2009‐1473272 Dissecting the role of NOD2 in the modulation of gut inflammation and fibrosis: relevance for Crohns Disease 15 biomedica Immunology € 533.500,00 1093 RF‐2009‐1491281 CELLULAR AND ANIMAL SYSTEMS IN MODELING HUMAN DISORDERS DUE TO ALTERED CONTENT AND/OR STABILITY OF mtDNA ASSOCIATED WITH MILD METHYLMALONIC ACIDURIA 15 biomedica Brain Disorders and Clinical Neuroscience € 528.000,00 1094 RF‐2009‐1485901 Molecular characterization of and therapeutic approach to muscle fibrosis in Duchenne muscular dystrophy 15 biomedica Musculoskeletal, Oral and Skin Sciences € 353.100,00 1095 RF‐2009‐1489536 ITALIAN SURVEY OF SERVICES AND PATHWAYS OF CARE FOR CHILDREN AND ADOLESCENT NEUROPSYCHYATRIC DISORDERS 15 clinico assistenziale Healthcare Delivery and Methodologies € 300.000,00 1096 RF‐2009‐1505131 Caveolin‐1 modulation of tumor associated macrophages (TAM) function 15 biomedica Oncology 1 ‐ Basic Translational € 203.500,00 1097 RF‐2009‐1505203 A CHARACTERISATION OF THE ALZHEIMERS DISEASE AND OF THE FRONTO‐PARIETAL DEMENTIA BASED ON A BIOCHEMICAL STUDY OF MICRO‐VESICLES PRESENT IN LIQUOR AND PLASMA SAMPLES 15 biomedica Brain Disorders and Clinical Neuroscience € 410.000,00 1098 RF‐2009‐1486299 Evaluation of the effectiveness of ADL‐based exercises Vs point‐to‐point reaching tasks in robot‐mediated therapy of the upper limb for sub‐acute stroke patients 15 biomedica Musculoskeletal, Oral and Skin Sciences € 600.000,00 1099 RF‐2009‐1472383 Clinical‐genetic study of Parkinson disease associated with glucosecerebrosidase mutations 15 clinico assistenziale Brain Disorders and Clinical Neuroscience € 360.250,00 1100 GR‐2009‐1491495 Role and Modulation of Jak and STAT signaling in Graft Rejection and Graft versus Host Disease 15 biomedica Immunology € 220.000,00 1101 GR‐2009‐1471184 Treatment of human melanoma xenograft by a potent, newly identified human CD8+ memory T cell subset 15 biomedica Immunology € 589.346,67 Pagina 96 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1102 RF‐2009‐1472605 Fase 2b trial: oral corticosteroids vs intra‐erythrocyte dexamethasone (EryDex) for the treatment of the CNS symptoms of patients with Ataxia Teleangectasia 15 clinico assistenziale Brain Disorders and Clinical Neuroscience € 198.250,00 1103 GR‐2009‐1492339 Identification and functional validation of microRNA biomarkers in lung cancer 15 biomedica Oncology 1 ‐ Basic Translational € 234.300,00 1104 RF‐2009‐1494485 Mitochondrial succinate dehydrogenase (SDH) mutations and pheochromocytoma/paraganglioma syndromes: biochemical and functional in vitro and in vivo (animal xenograft model) consequences of different SDH mutations. 15 biomedica Oncology 1 ‐ Basic Translational € 363.000,00 1105 RF‐2009‐1503981 Identification of expression networks as effectors of genetic susceptibility to lung cancer in a segregating mouse population 15 biomedica Genes, Genomes and Genetics € 333.300,00 1106 RF‐2009‐1469647 Pathogenesis of hemolytic uremic syndrome associated with Shiga toxin‐ producing Escherichia coli infections: understanding the mechanisms of toxin delivery from the gut to the target organ endothelia by clinical observations on patients with bloody diarrh 15 biomedica Infectious Diseases and Microbiology € 577.000,00 1107 RF‐2009‐1468779 Sensitizing glioma stem cells to radiotherapy and chemotherapy with cell cycle checkpoint and DNA repair inhibitors 15 biomedica Oncology 2 ‐ Translational Clinical € 153.000,00 1108 RF‐2009‐1483468 STUDY OF DIAGNOSTIC AND THERAPEUTIC INTERVENTIONS FOR ALLERGIC DISEASES IN LOMBARDY BY COST‐UTILITY ANALYSIS 15 clinico assistenziale Healthcare Delivery and Methodologies € 325.000,00 1109 RF‐2009‐1493009 Transition from commensal to nosocomial bacterial pathogens: an integrated approach for population based and lateral virulence gene transfer studies on hospital‐adapted streptococci and enterococci. 15 biomedica Infectious Diseases and Microbiology € 490.000,00 1110 RF‐2009‐1499203 Human Herpes virus 8 (HHV8) infection in transplanted patients: prevalence, seroconversion and Kaposi's Sarcoma development after transplantation. 15 clinico assistenziale Infectious Diseases and Microbiology € 400.000,00 1111 RF‐2009‐1471992 Novel Diagnostic Biomarkers for Global Brain Dysfunction following Aneurysmal Subarachnoid Hemorrhage and Therapeutic Intervention 15 biomedica Brain Disorders and Clinical Neuroscience € 158.750,00 1112 RF‐2009‐1473785 Second generation of prophylactic and therapeutic vaccines against HPV and related cancers. 15 biomedica Oncology 2 ‐ Translational Clinical € 592.000,00 Pagina 97 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1113 RF‐2009‐1472509 Clinical testing and mechanistic evaluation of caffeine as a potential therapeutic option for Alzheimer's disease. 15 clinico assistenziale Brain Disorders and Clinical Neuroscience € 567.000,00 1114 RF‐2009‐1503079 CELL CHARACTERIZATION AND ANALYSIS OF THE PROLIFERATIVE/DIFFERENTIATIVE POTENTIAL OF HUMAN COELOMIC FLUID CELLS FOR "IN UTERO" HAEMATOPOIETIC STEM CELL TRANSPLANTATION IN HAEMOGLOBINOPATHIES 15 biomedica Vascular and Hematology € 395.000,00 1115 RF‐2009‐1472038 Long QT syndrome type 2: functional characterization and identification of corrective strategies (GO‐QT2) 15 biomedica Genes, Genomes and Genetics € 546.200,00 1116 RF‐2009‐1473951 calorie restriction and cancer prevention: epigenetic and transcriptional mechanisms 15 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 1117 RF‐2009‐1471740 THE PHYSICAL CO‐MORBIDITY, HEALTH STATUS AND POOR HEALTH BEHAVIOUR OF TREATED PSYCHIATRIC PATIENTS WITH FUNCTIONAL PSYCHOSES. A multicentre prevalence study PHYSICO ‐ I 15 clinico assistenziale Population Sciences and Epidemiology € 600.000,00 1118 RF‐2009‐1500838 Phatogenetic mechanism of Malignant Pleural Mesothelioma development 15 biomedica Oncology 1 ‐ Basic Translational € 500.000,00 1119 RF‐2009‐1473012 Role of mGlu2 and mGlu3 metabotropic glutamate receptors in neurodegeneration/neuroprotection mechanisms 15 biomedica Molecular, Cellular, and Developmental Neuroscience € 300.000,00 1120 RF‐2009‐1492594 Is the Mycobacterium avium subspecies paratuberculosis present in cows linked to human Crohn's disease? A microbiological, molecular and genetic approach to a long‐lasting issue 15 biomedica Veterinary ‐ Animal Health ‐ ANHE € 371.800,00 1121 RF‐2009‐1469094 New approaches for in situ monitoring of immune responses in melanoma patients treated with combined chemo‐immunotherapy 15 biomedica Oncology 2 ‐ Translational Clinical € 392.000,00 1122 RF‐2009‐1492433 Residual morbidity and risk of relapse in patients cured of Cushing's syndrome 15 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 522.000,00 Pagina 98 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1123 RF‐2009‐1492613 ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION WITH REDUCED‐INTENSITY CONDITIONING REGIMEN IN PATIENTS WITH HIGH‐ RISK MYELOFIBROSIS: RANDOMIZED PHASE II STUDY BETWEEN FLUDARABINE PLUS BUSULPHAN OR THIOTEPA CONDITIONING REGIMENS 15 clinico assistenziale Vascular and Hematology € 297.000,00 1124 RF‐2009‐1475102 Systems biology for predictive biomarkers of responsiveness to cancer vaccines 15 biomedica Oncology 2 ‐ Translational Clinical € 524.000,00 1125 RF‐2009‐1526815 PRESERVATION OF THE REPRODUCTIVE FUNCTION IN ONCOLOGICAL CHILDREN AND WOMEN AT RISK OF STERILITY: OVARIAN TISSUE CRYOPRESERVATION USING A NON‐CONVENTIONAL ANTI‐OXIDANT IN HYPERBARIC CONDITIONS 15,17 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 250.000,00 1126 GR‐2009‐1591708 Definition of the epigenetic signature in Multiple Myeloma by high‐resolution DNA methylation analysis; an integrative genomic approach with allelic imbalances and mRNA‐microRNA expression profiling. 15,17 biomedica Oncology 1 ‐ Basic Translational € 361.500,00 1127 RF‐2009‐1474220 ATROPHY AND AUTOPHAGY AS KEY REGULATORS IN LIMB‐GIRDLE MUSCULAR DYSTROPHY AND IN METABOLIC MYOPATHIES 15,17 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 334.000,00 1128 RF‐2009‐1487395 Targeting the Met oncogene in osteosarcoma cancer stem cells 15,17 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 1129 RF‐2009‐1474501 Role of mitochondria in triggering cell loss in Huntington disease: molecular mechanisms, animal models and preclinical studies for validation of innovative target for pharmacological therapy 15,17 biomedica Molecular, Cellular, and Developmental Neuroscience € 595.000,00 1130 RF‐2009‐1525617 Redirecting T cells against prostate cancer by gene transfer of chimeric antigen receptors 15,25 biomedica Oncology 2 ‐ Translational Clinical € 583.000,00 1131 RF‐2009‐1532411 New therapeutic strategies for the control of fungal infections in the elderly 15,25 biomedica Biology of Development and Aging € 520.000,00 1132 GR‐2009‐1607237 Design and assessment of rehabilitation strategies in stroke subjects by integrating robotics and neuroimaging 15,25 biomedica Emerging Technologies and Training in Neurosciences € 420.900,00 1133 RF‐2009‐1548266 Identification and validation of microRNAs as novel biomarkers and therapeutic targets in prostate cancer 15,25 biomedica Oncology 2 ‐ Translational Clinical € 534.600,00 Pagina 99 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1134 GR‐2009‐1579979 Motor Imagery and Body Representation in Amiotrophic Lateral Sclerosis 15,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 229.000,00 1135 RF‐2009‐1505789 Broad functional monitoring of cellular and humoral immunity for rational post‐ transplant management of operational tolerance and infectious disease complications in liver transplant recipients undergoing immunosuppressive regimens with anti‐thymocyte glo 15,25 clinico assistenziale Immunology € 600.000,00 1136 GR‐2009‐1608478 Prevention of tissue injury in diabetes: novel approaches for marker and target discovery 15,25 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences 1137 GR‐2009‐1607551 VIROLOGICAL, IMMUNOLOGICAL AND GENETIC STUDIES ON HIV‐ INFECTED ITALIAN AND IMMIGRANT POPULATIONS IN ITALY. 15,25 clinico assistenziale AIDS and Related Research 1138 RF‐2009‐1528160 MULTICENTRE COMPARATIVE STUDY OF AMITRIPTYLINE, CARBAMAZEPINE AND PREGABALIN FOR FIRST‐LINE THERAPY IN CHRONIC PERIPHERAL NEUROPATHIC PAIN: RANDOMIZED TRIAL (the PainPAD trial) 15,25 clinico assistenziale Emerging Technologies and Training in Neurosciences 1139 GR‐2009‐1510900 Study of genetic bases of osteoporosis in a genetic isolate 15,25 biomedica Genes, Genomes and Genetics € 600.000,00 1140 RF‐2009‐1530995 Mediastinoscopy versus endobronchial ultrasound‐transbronchial needle aspiration in the preoperative staging of lung cancer patients: a prospective‐ randomized study 15,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 150.000,00 1141 RF‐2009‐1539509 Identification of biomarkers to predict thrombosis in a high risk cohort of cancer patients undergoing bevacizumab‐based regimens. 15,25 clinico assistenziale Vascular and Hematology € 300.000,00 1142 GR‐2009‐1584425 Design of glycopeptides as biomarkers for multiple sclerosis 15,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 200.000,00 1143 RF‐2009‐1550022 NF‐kB signaling pathway, microbial infections and neurodegeneration in Alzheimer's disease. 15,25 biomedica Infectious Diseases and Microbiology € 258.000,00 1144 RF‐2009‐1471294 Natural‐history model of lung cancer: characterization of genetic changes and cellular populations determining tumor invasiveness 15,25 biomedica Oncology 2 ‐ Translational Clinical € 489.500,00 € 301.500,00 € 588.500,00 € 367.125,00 Pagina 100 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1145 GR‐2009‐1471797 Development of an innovative system for sensing the wave aberration of human eyes based on diffractive multiple shearing interferometry 15,25 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 523.210,00 1146 GR‐2009‐1606670 Functional roles of MITOSTATIN, a novel putative Mitochondria‐Localized Tumor Suppressor protein 15,34 biomedica Oncology 1 ‐ Basic Translational € 337.500,00 1147 GR‐2009‐1605057 Low cost alternative prognostic and diagnostic biochemical surrogate markers to monitor HIV disease progression 15,34 biomedica AIDS and Related Research € 400.000,00 1148 GR‐2009‐1608556 The hypoxic microenvironment in Neuroblastoma tumors: relationship with the aggressive tumor phenotype 15,34 biomedica Oncology 1 ‐ Basic Translational € 500.000,00 1149 GR‐2009‐1568806 Mediators of inflammation and angiogenesis in Chronic Autoimmune Urticaria (CAU): new tools for the diagnosis and follow‐up 15,34 biomedica Immunology 1150 GR‐2009‐1583970 Novel aspects of medical therapy and phisopathology of ACTH‐secreting pituitary tumors 15,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 290.440,00 1151 RF‐2009‐1532496 Telomere length: a new marker for diabetic complications? 15,34 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 482.000,00 1152 RF‐2009‐1475730 Role of the pancreatic cancer microenvironment in conditioning CD4+ adaptive antitumor immunity and vice versa 15,34 biomedica Immunology € 375.000,00 1153 RF‐2009‐1492226 Developing a computer aided diagnosis system for detection of prostate cancer using multispectral MRI 15,34 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 288.818,76 1154 GR‐2009‐1607391 NANOVECTUCAM‐ Nanovectors for Targeted Visualization and Treatment of Undetectable Unstable Coronary Atherosclerotic Plaques using Magnetic Resonance Imaging In Vivo 15,5 biomedica Vascular and Hematology € 555.300,00 1155 GR‐2009‐1607719 GENETIC SUSCEPTIBILITY TO OXIDATIVE DNA DAMAGE: FROM SINGLE NUCLEOTIDE POLYMORPHISMS TO FUNCTION 15,5 biomedica Genes, Genomes and Genetics € 500.000,00 € 191.000,00 Pagina 101 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1156 GR‐2009‐1599967 Serotype distribution, antimicrobial resistance, and molecular characterization of Streptococcus pneumoniae isolates in two Italian regions from culture positive and culture negative clinical specimens 15,5 biomedica Infectious Diseases and Microbiology € 300.000,00 1157 GR‐2009‐1594715 A bright idea to detoxify CO poisoned patients 15,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 490.000,00 1158 RF‐2009‐1551363 Development, characterization and in vivo evaluation of innovative pharmaceutical formulations of the new potent painkiller peptide opiorphin 15,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 428.000,00 1159 GR‐2009‐1591227 Molecular characterization and functional analysis of amniotic fluid stem cells driven toward smooth muscle cell lineage ‐ potential for regenerative medicine 15,5 biomedica Cell Biology € 162.000,00 1160 RF‐2009‐1526251 Role of MET and MYC regulation in resistance to anti‐EGFR agents in colorectal and non‐small cell lung cancer 15,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 192.500,00 1161 GR‐2009‐1594593 Genistein effects on phosphorylated Tau in Alzheimer Disease investigated by Surface Enhanced RAMAN spectroscopy 15,5 biomedica Brain Disorders and Clinical Neuroscience € 461.000,00 1162 GR‐2009‐1580074 Preclinical testing of phosphoinositide 3‐kinases as therapeutic targets in heart failure 15,5 biomedica Cardiovascular and Respiratory Sciences € 600.000,00 1163 RF‐2009‐1511033 BIOCHEMICAL AND TISSUTAL RESPONSES IN FISH OF COMMERCIAL INTEREST FED MELAMINE AND CYANURIC ACID ENRICHED DIETS EVALUATING THE RISK ASSESSMENT FOR ANIMAL AND HUMAN HEALTH 15,5 biomedica Veterinary ‐ Animal welfare ‐ ANWE € 579.700,00 1164 RF‐2009‐1545469 A novel therapeutic approach for the cure of advanced prostate cancer 15,5 biomedica Oncology 2 ‐ Translational Clinical € 420.000,00 1165 GR‐2009‐1607124 Lung adenocarcinoma genomic initiative: characterization of oncogenic abnormalities and target validation in pulmonary adenocarcinoma 15,5 biomedica Oncology 2 ‐ Translational Clinical € 520.000,00 1166 RF‐2009‐1543416 Evaluation of anti‐TAT immunity (T and B) in the clinical, immunological and virological pathogenesis and progression of AIDS patients 15,5 biomedica AIDS and Related Research € 540.000,00 1167 GR‐2009‐1578019 MYH9 related disease: development of a strategy to genetically engineer mouse embryonic stem (ES) cells at high efficiency 15,5 biomedica Genes, Genomes and Genetics € 297.600,00 Pagina 102 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1168 RF‐2009‐1539539 A Phase I/II, Multicentre, Open label, Repeated Dose Range Finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of Bortezomib in association with Topotecan, Vincristine and Doxorubicine (TVD) in subjects with relapsed or refra 15,5 biomedica Oncology 2 ‐ Translational Clinical € 364.824,00 1169 GR‐2009‐1608883 Study of the viral and host correlates of mixed cryoglobulinemia 15,5 biomedica Genes, Genomes and Genetics € 178.700,00 1170 RF‐2009‐1530475 ATM heterozygosity as a major tumor‐susceptibility and radio‐sensitivity factor in the general population 15,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 418.000,00 1171 RF‐2009‐1544409 Novel class‐sparing regimens to achieve substantial CD4 gain in R5 HIV‐1 infected patients undergoing salvage therapy 15,5 clinico assistenziale AIDS and Related Research € 600.000,00 1172 RF‐2009‐1538754 Use of genistein in Alzheimer disease: from iron levels to neuronal modifications, a combined clinical and experimental approach 15,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 570.000,00 1173 GR‐2009‐1608602 Stroma‐derived SPARC critically regulates primary and secondary lymphoid tissues homeostasis and has a role in acute myeloid leukemia and lymphoma development. 15,5 biomedica Oncology 1 ‐ Basic Translational € 359.700,00 1174 RF‐2009‐1549231 A combined multidisciplinary approach to identify new HBV resistance determinants against last generation antiviral compounds. 15,5 biomedica Infectious Diseases and Microbiology € 580.000,00 1175 RF‐2009‐1530193 An integration system for in vivo and in vitro studies: application to patients with Ovarian Cancer 15,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 300.000,00 1176 GR‐2009‐1594529 Rare inherited disorders of HDL metabolism: from molecular diagnosis to therapeutic development 15,5 biomedica Genes, Genomes and Genetics € 510.000,00 1177 RF‐2009‐1536097 Alimentary human exposure to cadmium: intake evaluation and risk assessment 15,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 438.700,00 1178 GR‐2009‐1605512 Alterations of the resting state cortical networks: imaging biomarker for Frontotemporal Dementia. 15,5 biomedica Brain Disorders and Clinical Neuroscience € 510.950,00 1179 GR‐2009‐1608117 Role of morgana/chp‐1 in acute leukemia onset and progression 15,5 biomedica Oncology 1 ‐ Basic Translational € 290.000,00 Pagina 103 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1180 GR‐2009‐1606785 Epigenetic therapy and Rett syndrome: a pharmacological approach 15,5 biomedica Molecular, Cellular, and Developmental Neuroscience 1181 GR‐2009‐1567318 The Rorschach test in assessment of emotions and affective disorder in MS patients. 15,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 209.500,00 1182 RF‐2009‐1530016 IDENTIFICATION AND VALIDATION OF MOLECULAR MARKERS OF RESPONSE TO ADJUVANT CHEMOTHERAPY IN COLORECTAL CANCER 15,5 biomedica Oncology 2 ‐ Translational Clinical € 212.300,00 1183 RF‐2009‐1511210 Callosal agenesis: a complex brain malformation with heterogeneous genetic origin. Identification of new genes and loci through massive parallel DNA sequencing analysis in a large set of patient with corpus callosum anomalies 15,5 biomedica Genes, Genomes and Genetics € 330.000,00 1184 RF‐2009‐1471659 Gammadelta T lymphocytes in the control of HIV‐1 infection and coinfections: identification of tools to improve their survival and tissue localization. 15,5 biomedica AIDS and Related Research € 240.000,00 1185 RF‐2009‐1468753 Progeroid syndromes: a tool to evaluate the relative contribution of bioenergetic dysfunction and DNA repair defects to aging 15,5 biomedica Biology of Development and Aging € 600.000,00 1186 RF‐2009‐1505372 Variability of the platelet response to antiplatelet therapy defined by a combined functional and proteomic approach: predictive value of vascular events in patients undergoing coronary artery bypass grafting or elective percutaneous coronary intervention 15,5 biomedica Cardiovascular and Respiratory Sciences € 592.900,00 1187 GR‐2009‐1476279 Immunonogenicity of Mycobacterium tuberculosis antigen PPE44 for human T lymphocytes and interaction with human dendritic cells: implications for diagnosis and vaccine development. 15,5 biomedica Infectious Diseases and Microbiology € 150.000,00 1188 RF‐2009‐1498792 From MeCP2 gene mutation to disease expression in Rett syndrome through oxidative stress: Towards a new therapeutic strategy by a molecular‐level reinterpretation of the natural history of a major human pervasive developmental disorder 15,5 biomedica Biobehavioral and Behavioral Processes € 452.650,00 1189 RF‐2009‐1472993 Transgenic zebrafish model to visualize proliferation in vivo. 15,5 biomedica Cell Biology € 200.000,00 € 311.300,00 Pagina 104 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1190 RF‐2009‐1502143 IDENTIFICATION OF THE CELLULAR AND MOLECULAR TARGETS OF THE ANTI‐CANCER ACTIVITY OF HIV PROTEASE INHIBITORS: THE BASIS FOR A POTENTIAL NOVEL ANTITNEOPLASTIC COMPOUND 15,5 biomedica Interdisciplinary Molecular Sciences and Training € 575.000,00 1191 RF‐2009‐1490849 Persantine In non‐ischemic Cardiomyopathy 15,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 556.000,00 1192 RF‐2009‐1472999 Identification of new heart‐related miRNAs as tools for diagnosis and terapy of heart malformations and diseases 15,5 biomedica Cardiovascular and Respiratory Sciences € 419.000,00 1193 RF‐2009‐1473206 Tailored microRNA treatment of TCL1 driven lymphoproliferative disorders 15,5 biomedica Oncology 2 ‐ Translational Clinical € 511.500,00 1194 GR‐2009‐1473001 Realization of a gene array‐based method for the presurgical diagnosis of thyroid nodules 15,5 biomedica Oncology 1 ‐ Basic Translational € 440.500,00 1195 RF‐2009‐1475511 Exploitation of permissive donor‐recipient HLA‐DPB1 disparities for graft versus leukemia activity after hematopoietic stem cell transplantation 15,5 biomedica Immunology € 600.000,00 1196 RF‐2009‐1469202 Redox alteration in the tumor microenvironment. Role in inflammation and tumor progression, pharmacologic modulation 15,5 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 1197 RF‐2009‐1475040 Diverging molecular roles of MeCP2 and CDKL5: from partly overlapping networks to the pathogenesis of Rett syndrome and Hanefeld variant 15,5 biomedica Brain Disorders and Clinical Neuroscience € 505.000,00 1198 GR‐2009‐1608529 Lactic acid bacteria as "biodrugs" in human cancer prevention 15,6 biomedica Oncology 1 ‐ Basic Translational € 496.600,00 1199 RF‐2009‐1511448 Management and control models of risk factors for food intended for neutropenic population both in hospital environment and during domiciliation period 15,67 biomedica Veterinary ‐ Food Safety ‐ FOSA € 500.000,00 1200 RF‐2009‐1547822 Novel strategies and tools for clinical translation of autologous adult cardiac stem cells therapy 15,67 biomedica Cardiovascular and Respiratory Sciences € 600.000,00 1201 GR‐2009‐1575142 Pilot study comparing the safety and efficacy of the use of fixed‐dose combination efavirenz/tenofovir/emtricitabine (Atripla®) on alternate days versus standard of care in successfully treated HIV‐1 infected patients 15,75 clinico assistenziale AIDS and Related Research € 210.000,00 Pagina 105 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1202 GR‐2009‐1604222 EFFECT OF IMMUNOMODULATORY DRUGS ON microRNA EXPRESSION, MICROENVIRONMENT AND IMMUNE CELLS IN PATIENTS WITH LYMPHOPROLIFERATIVE DISEASES 15,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 495.000,00 1203 GR‐2009‐1580124 Analysis of development and persistence of specific memory B‐cells after new and routine vaccinations in HIV‐1 infected children and adolescents. 15,75 biomedica Immunology € 534.050,00 1204 GR‐2009‐1580852 Safe eradication of leukemic stem cells with suicide gene‐modified CD44v6‐ redirected T cells: a novel approach for adoptive immunotherapy of acute myelogenous leukemia 15,75 biomedica Oncology 2 ‐ Translational Clinical € 544.000,00 1205 GR‐2009‐1607381 Physical Exercise Interventions in Type 2 Diabetes: Clinical and Economic Impact 15,75 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 1206 GR‐2009‐1607159 Antiviral Immune Responses in Lymph Nodes 15,75 biomedica Immunology € 600.000,00 1207 GR‐2009‐1566579 Clinical prevalence and study of pathogenetic mechanisms of neurologic disorders associated with mutations of mitochondrial carrier genes 15,75 biomedica Brain Disorders and Clinical Neuroscience € 332.000,00 1208 GR‐2009‐1579654 Human Neural Stem Cells for the cure of Amyotrophic Lateral Sclerosis 15,75 biomedica Brain Disorders and Clinical Neuroscience € 589.600,00 1209 RF‐2009‐1503115 Tumor‐Stroma Interaction in thyroid cancer: Contribution of Cell Stress 15,75 biomedica Oncology 1 ‐ Basic Translational € 368.000,00 1210 RF‐2009‐1469568 Characterization of immune responses against incipient neoplasia in BRCA1/BRCA2 germ‐line mutation carriers: possible role for cancer risk modulating immunotherapy? 15,75 biomedica Immunology € 550.000,00 1211 RF‐2009‐1472500 Intrasubtypic and intersubtypic cross‐reactivity as a novel approach to pandemic influenza preparedness programmes 15,75 biomedica Immunology € 600.000,00 1212 RF‐2009‐1501301 A systematic immune‐monitoring and tumor microenvironment dissection in a combined chemo‐immunotherapeutic trial of melanoma patients: searching for novel predictive or surrogate biomarkers 15,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 499.400,00 1213 RF‐2009‐1476221 A randomized controlled trial of the effectiveness of a depression screening and management program in cardiovascular care 15,75 clinico assistenziale Biobehavioral and Behavioral Processes € 599.830,00 Pagina 106 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1214 RF‐2009‐1471961 Protective or seizure‐precipitating effects of interictal events in focal epilepsy 15,75 biomedica Brain Disorders and Clinical Neuroscience € 445.500,00 1215 RF‐2009‐1548615 Human Papilloma Virus Infection in HIV positive, immigrant and pregnant women: an integrated molecular and clinical approach 15,8 clinico assistenziale Oncology 1 ‐ Basic Translational € 182.000,00 1216 RF‐2009‐1537428 Identification of oxidative stress biomarkers as surrogate outcome measures of oxygen therapy and exercise rehabilitation programs in chronic respiratory diseases. 15,84 clinico assistenziale Cardiovascular and Respiratory Sciences € 594.000,00 1217 GR‐2009‐1568800 Innovative strategy of tissue regeneration in acute and chronic kidney graft dysfunction: role of endothelial progenitor cell‐derived microvesicles 15,84 biomedica Digestive, Kidney and Urological Systems € 390.000,00 1218 GR‐2009‐1605833 Unique processing of DNA damage in adult stem cells 15,84 biomedica Oncology 1 ‐ Basic Translational € 585.300,00 1219 GR‐2009‐1525989 Extending the knowledge on human and animal astroviruses (Astroviridae family): identification, genetic and biological characterization of a novel astrovirus in rabbits. 15,84 biomedica Veterinary ‐ Animal Health ‐ ANHE € 432.000,00 1220 GR‐2009‐1574292 Correlations between inflammatory cytokines and haematopoietic and endothelial stem cells function in type 2 diabetes mellitus 16 biomedica Vascular and Hematology € 176.000,00 1221 GR‐2009‐1608934 Role of satellite cell‐mediated regeneration of muscle fibers in facioscapulohumeral muscular dystrophy 16 biomedica Biology of Development and Aging € 516.565,00 1222 RF‐2009‐1530093 Epidemiological evaluation of health status, drug prescriptions and pediatric care in a cohort of newborn followed up for 18 months. 16 clinico assistenziale Population Sciences and Epidemiology € 566.500,00 1223 RF‐2009‐1532297 Percutaneous Tibial Nerve Stimulation (PTNS) as new rehabilitative treatment for chronic pelvic pain in patients with pelvic cancer 16 clinico assistenziale Brain Disorders and Clinical Neuroscience € 300.000,00 1224 GR‐2009‐1606749 Pathogenetic mechanism and novel strategies to target cardiac autonomic dysfunction in aging hearts. 16 biomedica Cardiovascular and Respiratory Sciences € 406.000,00 Pagina 107 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1225 GR‐2009‐1607884 IMPLEMENTATION OF TWO NOVEL DEVICES FOR VESTIBULAR DIAGNOSIS, ASSESSMENT, AND TAILORED HOME‐BASED REHABILITATION PROGRAMS, AND CONTROLLED TRIAL OF VESTIBULAR REHABILITATION FOR CENTRAL VESTIBULAR DISORDERS. 16 clinico assistenziale Integrative, Functional, and Cognitive Neuroscience € 313.520,00 1226 GR‐2009‐1605602 Role of the endocytic machinery in cancer 16 biomedica Oncology 1 ‐ Basic Translational € 373.333,00 1227 RF‐2009‐1528958 Effect of palmitoleic acid treatment on AMPK pathway and on CAMK4 and DCAMKL1, genes previously associated with exceptional longevity and candidates to be regulated by palmitoleate being the former in AMPK pathway and latter repressing CAMK4 induced CREB 16 biomedica Biology of Development and Aging € 150.000,00 1228 GR‐2009‐1605505 New Therapeutic Strategies Overcoming Opportunistic Infections 16 biomedica Infectious Diseases and Microbiology € 590.000,00 1229 RF‐2009‐1546833 Identification of gender‐related differences in oxidative stress biomarkers associated with atherosclerotic disease progression 16 clinico assistenziale Vascular and Hematology € 538.700,00 1230 RF‐2009‐1531263 Vascular ageing in the complex pathways of cardiovascular determinants of cognitive decline in older subjects 16 clinico assistenziale Biology of Development and Aging € 600.000,00 1231 RF‐2009‐1529043 Silk fibroin cells delivery systems and autologous mesenchymal stem cells: innovative, non‐invasive treatment for intervertebral disc degeneration 16 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 226.600,00 1232 RF‐2009‐1511345 The Williams Beuren sydrome as model to investigate the role of miRNAs in genomic disorders 16 biomedica Genes, Genomes and Genetics € 298.000,00 1233 GR‐2009‐1600194 Understanding thyroid cancer genetics: new approaches for a better cure (THYGER) 16 biomedica Oncology 1 ‐ Basic Translational € 364.128,00 1234 GR‐2009‐1606855 Primary motor cortex and brainstem plasticity in patients with Gilles de la Tourette Syndrome and Obsessive Compulsive Disorder 16 biomedica Brain Disorders and Clinical Neuroscience € 313.500,00 1235 GR‐2009‐1577644 RESHAL Regional Study on Health and Ageing in Lombardia 16 clinico assistenziale Population Sciences and Epidemiology € 431.707,00 Pagina 108 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1236 GR‐2009‐1546924 BIG‐GGT‐CARDIO PROJECT: Set‐up and clinical validation of a new immunometric assay for quantification of big‐gamma‐glutamyltransferase (big‐ GGT), an emerging biomarker for cardiovascular risk stratification. 16 biomedica Biological Chemistry and Macromolecular Biophysics € 407.000,00 1237 GR‐2009‐1606211 New diagnostic approaches for familial hyperlipidemias 16 biomedica Genes, Genomes and Genetics € 490.000,00 1238 RF‐2009‐1549607 DISTANT METASTASIS IN NODE‐NEGATIVE BREAST CANCERS: INVESTIGATING THE ROLE OF INFLAMMATORY RESPONSE GENES 16 biomedica Oncology 2 ‐ Translational Clinical € 464.200,00 1239 GR‐2009‐1606639 COL4A1/COL4A2 gene mutations in patients with deep cerebral hemorrhage 16 clinico assistenziale Brain Disorders and Clinical Neuroscience € 290.000,00 1240 GR‐2009‐1594599 Mechanisms of tumor progression from pre‐tumoral stem cells 16 biomedica Oncology 1 ‐ Basic Translational € 508.300,00 1241 RF‐2009‐1519681 EVALUATION OF THE CHEMOSENSITIZING EFFECT OF THE PLANT ALKALOID VOACAMINE ON OSTEOSARCOMA AND EWING'S SARCOMA: AN IN VITRO, IN VIVO AND CLINICAL STUDY. 16 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 1242 GR‐2009‐1605560 Role of endocannabinoids signaling in remote damage after spinal cord injury. 16 biomedica Brain Disorders and Clinical Neuroscience € 409.200,00 1243 GR‐2009‐1568272 Role of the growth factors activin and myostatin and their related proteins in leiomyoma formation 16 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 403.000,00 1244 GR‐2009‐1591876 MicroRNA‐101 depletion in the brain: exploring microRNA‐101 as a molecular basis for Alzheimer's disease. 16 biomedica Brain Disorders and Clinical Neuroscience 1245 GR‐2009‐1606664 Time‐Course of Platelet Activation During the Development and Progression of Type 2 Diabetes Mellitus: Validation of Platelet Biomarkers for Predicting Thrombotic Risk and Testing Novel Preventive Strategies 16 clinico assistenziale Vascular and Hematology € 264.000,00 1246 GR‐2009‐1603058 Development of a chimeric antibody targeting the matricellular protein 90K, as a novel therapeutic agent for cancer 16 biomedica Oncology 2 ‐ Translational Clinical € 430.000,00 € 600,00 Pagina 109 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1247 GR‐2009‐1606809 Use of diazoxide and mTOR activators for treatment of Friedreich's ataxia 16 biomedica Molecular, Cellular, and Developmental Neuroscience € 337.000,00 1248 GR‐2009‐1552468 Impact of DNp63 on resistance mechanism to chemotherapy 16 biomedica Oncology 1 ‐ Basic Translational € 425.000,00 1249 GR‐2009‐1591820 Palmitoylethanolamide: a possible new therapeutic approach for inflammatory bowel diseases 16 biomedica Digestive, Kidney and Urological Systems € 241.500,00 1250 RF‐2009‐1530195 Biomarkers identification and validation for malignant mesothelioma: from molecular biology to clinical practice 16 biomedica Oncology 2 ‐ Translational Clinical € 255.000,00 1251 GR‐2009‐1608308 Nucleolin‐mediated breast cancer diagnostics and therapy 16 biomedica Cell Biology € 415.500,00 1252 GR‐2009‐1578294 Innovative preclinical molecular imaging techniques 16 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 530.000,00 1253 RF‐2009‐1510910 Characterization of different human Mesodermal Stromal Cell populations: applications for regenerative medicine and bone marrow transplantation 16 biomedica Biology of Development and Aging € 380.000,00 1254 GR‐2009‐1539532 Pathway‐based analysis of ischemic stroke subtypes assessed by genome‐wide association study 16 clinico assistenziale Genes, Genomes and Genetics € 572.000,00 1255 RF‐2009‐1547379 Environmental, genetic and epigenetic factors in amyotrophic lateral sclerosis 16 biomedica Brain Disorders and Clinical Neuroscience € 472.097,83 1256 RF‐2009‐1547837 Siglec‐7 in immune response to viral infections: a potential cellular biomarker capable of identifying the clinical stages of HIV‐1 and HCV infections. 16 biomedica Immunology 1257 RF‐2009‐1535140 Optimization of Tissue microarrays (TMA) technology for immunohistochemestry in colorectal cancer: development of a pre‐screening model for Hereditary Nonpolyposis Colorectal Cancer (HNPCC) 16 biomedica Oncology 2 ‐ Translational Clinical € 230.000,00 1258 RF‐2009‐1543768 AGE IN DIET AND BLOOD, CARDIOVASCULAR DISEASE, CANCER AND COGNITIVE DECLINE. A POPULATION STUDY IN SOUTHERN ITALY. 16 biomedica Population Sciences and Epidemiology € 540.000,00 € 110.000,00 Pagina 110 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1259 RF‐2009‐1548702 Deep inside the oxaliplatin neurotoxicity: new SOD‐mimetic compounds as strategy to prevent and cure neuropathy 16 biomedica Oncology 2 ‐ Translational Clinical € 358.000,00 1260 RF‐2009‐1511277 Facioscapulohumeral muscular dystrophy: serial muscle MRI study, immunological surveillance and biomolecular characterization of affected versus unaffected muscles to define non‐invasive outcome measures, assess the role of inflammation and elucidate the 16 biomedica Musculoskeletal, Oral and Skin Sciences € 500.000,00 1261 RF‐2009‐1511408 Ferritin and ferritin‐related metals as diagnostic tools in Alzheimer's disease 16 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 1262 RF‐2009‐1524421 Effect of Sunitinib treatment on circulating tumor cells (CTC) in metastatic renal cancer (mRCC) 16 biomedica Oncology 2 ‐ Translational Clinical € 486.200,00 1263 RF‐2009‐1547402 The relation between neurodegeneration and inflammation in Multiple Sclerosis: NR4A2 puts a dampener on inflammation 16 biomedica Brain Disorders and Clinical Neuroscience € 287.300,00 1264 GR‐2009‐1594961 Establishment of a new diagnostic tool for an innovative molecular analysis of Fragile X syndrome and premutation associated diseases. 16 biomedica Genes, Genomes and Genetics € 215.000,00 1265 RF‐2009‐1528678 Setting up a new LC‐MS method for determination of palytoxin and ovatoxin‐a as an alternative method to mouse bioassay in seafood analyses 16 biomedica Interdisciplinary Molecular Sciences and Training € 600.000,00 1266 RF‐2009‐1523227 MicroRNAs as novel sensitive diagnostic and prognostic biomarkers of myocardial infarction 16 clinico assistenziale Cardiovascular and Respiratory Sciences € 562.000,00 1267 GR‐2009‐1510976 COMT x Dysbindin double ko mice will help humans in early detection of schizophrenia 16 biomedica Biobehavioral and Behavioral Processes € 492.223,00 1268 RF‐2009‐1537818 Host and viral factors as biomarkers of treatment outcomes in chronic B and C hepatitis 16 clinico assistenziale Infectious Diseases and Microbiology € 600.000,00 1269 GR‐2009‐1605270 Small Ubiquitin‐like Modifier (SUMO)‐dependent regulation of Na+/Ca2+ exchanger (NCX) isoforms in cerebral ischemia: a strategy for identifying new targets for therapeutic intervention 16 biomedica Molecular, Cellular, and Developmental Neuroscience € 414.200,00 Pagina 111 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1270 RF‐2009‐1529305 DNA Damage induced by potential new antineoplastic drugs: Role in Toxicity and Mutagenicity 16 biomedica Oncology 1 ‐ Basic Translational € 322.560,00 1271 RF‐2009‐1548188 Efficacy of active research and access to cure promotion for tuberculosis in migrants accessing primary health centres and Roma camps. 16 clinico assistenziale Healthcare Delivery and Methodologies € 272.850,00 1272 GR‐2009‐1600580 The critical problem of Multiple Sclerosis patients troubled by spasticity who are non‐responders or intolerant to oral anti‐spastic drugs: a wide randomized‐ controlled study comparing the effect of focal muscle vibration and neuromuscular taping on gait 16 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 152.500,00 1273 GR‐2009‐1594651 Impact of myocardial 123I‐metaiodobenzylguanidine (mIBG) imaging on patient selection and risk stratification before device therapy for heart failure. Correlation with residual myocardial viability and cost‐effectiveness evaluation. 16 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 506.000,00 1274 GR‐2009‐1607138 Neurobiology of frataxin and neuroprotective effects of alpha lipoic acid and EPO in a new in‐vitro model of Friedreich Ataxia 16 biomedica Molecular, Cellular, and Developmental Neuroscience € 167.200,00 1275 RF‐2009‐1548108 Feasibility study on adipose stem cells transplantation from autologous fat tissue in thoracic surgery 16 biomedica Oncology 2 ‐ Translational Clinical € 283.800,00 1276 GR‐2009‐1594611 New methods for Non‐ionizing imaging and guidance of ENDOvascular devices in CArdiac Surgery (NENDOCAS) 16 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 594.000,00 1277 RF‐2009‐1511098 Innovative therapeutic approaches against CD49d‐driven microenvironmental interactions in chronic lymphocytic leukemia and multiple myeloma 16 biomedica Oncology 1 ‐ Basic Translational € 498.000,00 1278 RF‐2009‐1511063 INDOLEAMINE 2,3‐DIOXYGENASE (IDO) AND TRYPTOPHAN‐DIOXYGENASE (TDO) AS POTENTIAL TARGETS FOR THERAPEUTIC AGENTS USEFUL IN POST‐ISCHEMIC BRAIN DAMAGE 16 biomedica Brain Disorders and Clinical Neuroscience 1279 GR‐2009‐1607178 PDGF receptor alpha agonists as inhibitors of melanoma growth in vivo 16 biomedica Oncology 1 ‐ Basic Translational € 314.661,00 1280 GR‐2009‐1607289 IDENTIFICATION OF RELIABLE BIOMARKERS OF DIABETIC NEPHROPATHY BY POWERFUL AND COMPLEMENTARY PROTEOMIC STRATEGIES 16 biomedica Digestive, Kidney and Urological Systems € 379.575,00 € 201.000,00 Pagina 112 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1281 RF‐2009‐1470712 Development of effective cancer therapies based on functional proteomics and cancer stem cell targeting 16 biomedica Oncology 2 ‐ Translational Clinical € 500.000,00 1282 RF‐2009‐1493906 UNDER‐PHOSPHORYLATED MECP2 AS A NEW THERAPEUTIC STRATEGY IN RETT SYNDROME 16 biomedica Brain Disorders and Clinical Neuroscience € 396.888,00 1283 RF‐2009‐1470038 FISABILITY OF A HOME‐BASED PALLIATIVE CARE PROGRAM FOR NON‐ ONCOLOGIC PATIENTS 16 clinico assistenziale Healthcare Delivery and Methodologies € 334.950,00 1284 RF‐2009‐1471927 MicroRNA‐regulated expression of HLA‐G and tolerance via adaptive regulatory T cells induced by tolerogenic dendritic cells 16 biomedica Immunology € 600.000,00 1285 RF‐2009‐1472552 Prion‐like transmission in neurodegenerative protein‐misfolding disorders (PRIMIS) 16 biomedica Molecular, Cellular, and Developmental Neuroscience 1286 RF‐2009‐1491613 Prevention of severe toxicity by fluoropyrimidines by screening dihydropyrimidine dehydrogenase variants. 16 biomedica Oncology 2 ‐ Translational Clinical 1287 RF‐2009‐1471313 IMMUNOTHERAPY FOR FOOD ALLERGY WITH TOLEROGENIC ALLERGEN TOOLS: PRECLINICAL STUDY IN MOUSE MODELS OF SENSITIZATION AND ANAPHYLAXIS 16 biomedica Immunology 1288 RF‐2009‐1475128 The role of inflammatory network and associated brain micro‐ and macro‐ structural damage in longitudinal neuropsychiatric symptom expression in patients with Mild Cognitive Impairment and early Alzheimer disease 16 biomedica Brain Disorders and Clinical Neuroscience € 386.208,00 1289 RF‐2009‐1475668 TOXIC EFFECTS INDUCED BY POLYAMINE METABOLITES ON MELANOMA CELLS: A NEW THERAPEUTIC APPROACH 16 biomedica Oncology 1 ‐ Basic Translational € 590.000,00 1290 RF‐2009‐1503103 A cohort study of persons with hepatitis C and/or hepatitis B virus infections in southern and northern Italy 16 biomedica Population Sciences and Epidemiology € 254.500,00 1291 RF‐2009‐1475559 ALTERNATIVE AND RELIABLE IN VITRO METHOD FOR BONE IMPLANT BIOMATERIAL BIOCOMPATIBILITY AND OSTEOINTEGRATION 16 biomedica Veterinary ‐ Animal welfare ‐ ANWE € 226.000,00 1292 RF‐2009‐1475224 Biological Networks of host‐pathogens interplay in genital cancers: Determinants of Cancer Susceptibility and response to Therapy 16 biomedica Oncology 1 ‐ Basic Translational € 527.000,00 € 501.444,00 € 200.000,00 € 513.700,00 Pagina 113 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1293 RF‐2009‐1504404 The role of the association of two urinary biomarkers (PCA3mRNA and GSTP1) in the diagnosis of the prostate cancer 16 clinico assistenziale Digestive, Kidney and Urological Systems € 360.000,00 1294 RF‐2009‐1490602 Proteomic signatures as biomarkers of breast cancer risk and as predictors of outcome in women with early breast cancer. 16 biomedica Oncology 2 ‐ Translational Clinical € 470.000,00 1295 RF‐2009‐1473857 Selective NF‐kappaB inhibitory peptides: a first step toward novel anti cancer therapeutics 16 biomedica Oncology 2 ‐ Translational Clinical € 480.000,00 1296 RF‐2009‐1490868 Tumor microenvironment and host immune response: characterization of new mechanisms of tumor evasion and identification of possible therapeutic targets. 16 biomedica Oncology 1 ‐ Basic Translational € 450.000,00 1297 RF‐2009‐1504126 The separate roles of long‐lived plasma cells and memory B cells in protection and autoimmunity . 16 biomedica Immunology € 551.000,00 1298 RF‐2009‐1491438 HIGH‐THROUGHPUT DRUGS SCREENING IN CELLULAR MODELS OF OSTEOBLAST DIFFERENTIATION AND CYSTIC FIBROSIS 16 biomedica Genes, Genomes and Genetics € 507.100,00 1299 RF‐2009‐1475755 Anticancer therapies based on correcting TGFß+ associated immune dysfunctions in myeloid cells 16 biomedica Immunology € 367.400,00 1300 RF‐2009‐1486487 Multifactorial analysis of indicators of short and long term outcomes in long‐term mechanically ventilated patients 16 clinico assistenziale Cardiovascular and Respiratory Sciences € 510.000,00 1301 RF‐2009‐1475647 Planar Cell Polarity signaling and Neural Tube Defects 16 biomedica Genes, Genomes and Genetics € 353.923,00 1302 GR‐2009‐1594676 Construction of an IL‐23/p40 antagonist: study of a potential immunology target in multiple sclerosis 16,17 biomedica Immunology € 242.857,00 1303 RF‐2009‐1548790 Clinical and economical impact of advanced molecular strategies for bacterial and fungal diagnosis in oncohematological patients with suspected sepsis 16,17 clinico assistenziale Infectious Diseases and Microbiology € 600.000,00 1304 RF‐2009‐1530566 Novel strategies to limit post‐ischemic myocardial damage: vagal nerve stimulation and stem cells therapy 16,17 biomedica Cardiovascular and Respiratory Sciences € 600.000,00 1305 RF‐2009‐1470435 Innovative diagnostic and prognostic biomarkers in primary systemic vasculitides 16,17 biomedica Immunology € 580.000,00 Pagina 114 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto € 401.500,00 1306 RF‐2009‐1549477 Genotoxic effects related to pesticide exposure in greenhouses: a novel biomonitoring approach 16,2 biomedica Oncology 1 ‐ Basic Translational 1307 RF‐2009‐1549263 PATHOPHYSIOLOGICAL EVALUATION AND THERAPEUTIC APPROACHES FOR THE NEUROLOGICAL INVOLVEMENT AFFECTING LYSOSOMAL STORAGE DISORDERS 16,25 biomedica Brain Disorders and Clinical Neuroscience € 314.533,00 1308 GR‐2009‐1592245 Genetic, functional and structural correlates of cognitive and emotional impairment in Mood Disorders. 16,25 biomedica Brain Disorders and Clinical Neuroscience € 495.500,00 1309 GR‐2009‐1580409 Disclosing LOX‐1, the key receptor in endothelial dysfunction and atherosclerosis 16,25 biomedica Biological Chemistry and Macromolecular Biophysics € 510.000,00 1310 GR‐2009‐1595518 Monitoring drug resistance in the canine reservoir of human leishmaniases 16,25 biomedica Infectious Diseases and Microbiology € 245.575,00 1311 GR‐2009‐1580459 Mild Cognitive Impairment: towards a neuromodulatory cognitive rehabilitation of the memory disorder 16,25 biomedica Brain Disorders and Clinical Neuroscience € 359.560,00 1312 GR‐2009‐1608659 HUMAN HIPPOCAMPAL TISSUE TRANSPLANTATION AS A NOVEL STRATEGY FOR THE TREATMENT OF ALZHEIMER'S DISEASE 16,25 biomedica Brain Disorders and Clinical Neuroscience € 460.000,00 1313 GR‐2009‐1601035 Mother‐delivered infant massage as a cost‐effective model for early intervention in preterm infants: effects on infant brain development, mothers mental health and mother‐infant relationship. 16,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 449.460,00 1314 RF‐2009‐1548186 Aromatase inhibitors as adjuvant treatment of breast cancer 16,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 600.000,00 1315 RF‐2009‐1538006 Biomarker studies on Vitamin D and Melanoma 16,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 405.000,00 1316 GR‐2009‐1594684 Potential Therapeutic Usage Of GM1 Ganglioside In Huntington Disease (HD) 16,25 biomedica Brain Disorders and Clinical Neuroscience € 300.000,00 1317 RF‐2009‐1530633 Tissue cytokine response in Leishmania infantum naturally infected dogs treated with different therapy 16,25 clinico assistenziale Veterinary ‐ Animal Health ‐ ANHE € 524.000,00 Pagina 115 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1318 GR‐2009‐1607351 Motor control in relation with visual processing in children with autism 16,25 biomedica Brain Disorders and Clinical Neuroscience € 453.700,00 1319 GR‐2009‐1569634 Remote post‐conditioning as new therapeutic avenue to treat cerebral ischemia 16,25 biomedica Molecular, Cellular, and Developmental Neuroscience € 419.600,00 1320 GR‐2009‐1552384 Gut microbiota and inflammatory diseases 16,25 biomedica Genes, Genomes and Genetics € 599.600,00 1321 RF‐2009‐1474076 Development of T regulatory cells‐based strategies for immunotherapy in haploidentical stem cell transplantation for patients with haematological malignancies 16,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 370.000,00 1322 RF‐2009‐1476285 Primary prevention of Neural Tube Defects: Periconceptional Inositol supplementation of women with a previous affected pregnancy 16,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 223.797,00 1323 RF‐2009‐1502142 Role of microRNAs in papillary thyroid carcinoma: pathways involved and possible therapeutic targets 16,25 biomedica Oncology 1 ‐ Basic Translational € 314.050,00 1324 RF‐2009‐1545106 Hepatitis B virus in the etiology of non‐Hodgkin lymphoma and disease biomarkers: an Italian multicentre study 16,34 biomedica Population Sciences and Epidemiology € 327.800,00 1325 GR‐2009‐1600677 In vitro and in vivo differentiation of human amniotic epithelial stem cells into functional mature hepatocytes 16,34 biomedica Digestive, Kidney and Urological Systems € 338.000,00 1326 RF‐2009‐1530565 Proteomics of benign and malignant parathyroid tumors: mechanisms of oncogenic transformation and identification of molecular and humoral biomarkers for early diagnosis of sporadic and familial parathyroid cancer 16,34 biomedica Oncology 1 ‐ Basic Translational € 500.000,00 1327 RF‐2009‐1469716 Inflammation, insulin resistance and cardio‐metabolic risk: phosphodiesterase Type 5 role in the pathophysiology of cardiometabolic diseases (from cell culture to obese and type 2 diabetic patients) 16,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 482.040,00 1328 GR‐2009‐1530449 Molecular and Cellular Analysis of GnRH‐1 Neuronal Development: Implications in Hypogonadotropic Hypogonadisms 16,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 245.000,00 Pagina 116 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1329 RF‐2009‐1530743 Molecular epidemiology and behavioural determinants of HAV and HCV hepatitis among men who have sex with men in some Italian metropolitan areas 16,5 clinico assistenziale Infectious Diseases and Microbiology € 589.000,00 1330 GR‐2009‐1604636 Multifunctional nanopore arrays tailored with angiogenesis inhibitors and cancer cell death ligands: an innovative hybrid nanodevice for a new effective cancer therapy. 16,5 biomedica Bioengineering Sciences and Technologies € 500.252,00 1331 RF‐2009‐1506122 Seafood safety and public health: development and validation of analytical methodologies for species identification to guarantee correct labelling of fishery products in Italy. 16,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 206.800,00 1332 RF‐2009‐1550536 Effects of metabolic conditions that modify vascular function on HDL levels and endothelial progenitor cells 16,5 biomedica Vascular and Hematology € 345.000,00 1333 GR‐2009‐1608610 Development of New Genotypic and Phenotypic Assays for the Analysis of Drug Resistance in HIV‐1 Infected Patients Treated with Integrase Inhibitors. Synthesis and Evaluation of New Compounds Against HIV Resistant Variants 16,5 biomedica AIDS and Related Research € 591.000,00 1334 RF‐2009‐1529413 Modulation of autophagy and apoptosis in Mycobacterium tuberculosis‐host interaction: role of Transglutaminase type II. 16,5 biomedica Infectious Diseases and Microbiology € 425.000,00 1335 GR‐2009‐1606207 Integrated approach for the identification of peripheral biological markers for Anorexia Nervosa. 16,5 biomedica Biobehavioral and Behavioral Processes € 600.000,00 1336 GR‐2009‐1594567 Dissecting the Polycomb‐mediated epigenetic determination of stem identity in adult stem cells 16,5 biomedica Genes, Genomes and Genetics € 260.000,00 1337 GR‐2009‐1592013 Effect of a population‐based public communication campaign to improving awareness and knowledge on palliative care. A quasi‐experimental study in the Liguria Region. 16,5 clinico assistenziale Healthcare Delivery and Methodologies € 560.000,00 1338 GR‐2009‐1594745 Towards a therapeutic anti‐metastatic breast cancer in a mouse model by validation of new generated drugs 16,5 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 1339 GR‐2009‐1584319 A multimodality approach to cancer cachexia. Clinical translational study to evaluate the efficacy of an oral, ambulatorial, low cost treatment approach on novel patient‐centred outcomes of cancer cachexia 16,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 395.000,00 Pagina 117 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1340 GR‐2009‐1607174 Tumor regression grade (TRG) and erb‐B2 expression in resectable carcinomas of stomach and gastro‐oesophageal junction after neoadjuvant chemotherapy: clinical and pathological correlations 16,5 biomedica Oncology 2 ‐ Translational Clinical € 150.000,00 1341 RF‐2009‐1526078 Canonical Wnt signaling in CNS regeneration 16,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 333.000,00 1342 GR‐2009‐1591161 Immunogenetics of Myasthenia Gravis by genome wide association scan (GWAS) analysis 16,5 biomedica Immunology 1343 RF‐2009‐1527333 Inner Retinal Dysfunction of the Cone System in Inherited Photoreceptor Degenerations: A Study of Disease Sequence and Assessment of Novel Therapeutic Strategies. 16,5 clinico assistenziale Genes, Genomes and Genetics € 153.600,00 1344 GR‐2009‐1579200 Robotic therapy for the rehabilitation of lower limbs in pediatrics 16,5 biomedica Musculoskeletal, Oral and Skin Sciences € 330.000,00 1345 GR‐2009‐1605111 Perceiving actions to improve their execution in brain damaged patients. 16,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 450.000,00 1346 RF‐2009‐1529582 Epidemiological and toxicogenomics approaches for the evaluation of the adverse reproductive outcomes associated with airborne exposure 16,5 biomedica Genes, Genomes and Genetics € 600.000,00 1347 RF‐2009‐1523896 Development of an Integrated MRI/SPECT System for Monitoring Ischemic Stroke and Stem Cell Transplantation 16,5 biomedica Emerging Technologies and Training in Neurosciences € 600.000,00 1348 GR‐2009‐1607762 Amniotic fluid stem cells are involved in muscle stem cells niche repopulation 16,5 biomedica Musculoskeletal, Oral and Skin Sciences € 160.000,00 1349 GR‐2009‐1528979 Dissecting the neural basis of behavior through multimodal imaging and computational modeling of decision‐making in health and neuropsychiatric disorders 16,5 biomedica Biobehavioral and Behavioral Processes € 583.260,00 1350 RF‐2009‐1528952 18F‐Fluorohymidine Positron Emission Tomography as an early predictor of response to neoadjuvant therapy in patients with locally advanced breast carcinoma 16,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 332.000,00 € 600.000,00 Pagina 118 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1351 RF‐2009‐1519690 PHARMACOGENOMICS OF ANTIDEPRESSANT DRUGS: PHARMACOGENETIC OF SSRIs, AND THE APPROPRIATE PRESCRIPTION OF ANTIDEPRESSANT AGENTS IN MILD AND MODERATE MOOD DEPRESSIVE DISORDERS IN GENERAL PRACTICE, SOMATIC CO‐MORBIDITY AND COMMUNITY CARE 16,5 biomedica Genes, Genomes and Genetics € 180.000,00 1352 GR‐2009‐1569734 Generation and preclinical validation of myocardial bio‐substitutes fabricated with human autologous stem cells for heart mending 16,5 biomedica Cardiovascular and Respiratory Sciences € 525.500,00 1353 GR‐2009‐1570218 Inhibition of human Follicular Lymphoma cells growth by a PNA specific for t(8;14) translocated bcl2 16,5 biomedica Oncology 2 ‐ Translational Clinical € 250.000,00 1354 GR‐2009‐1600986 Characterization of epigenetic changes in mammary Stem Cells in mice subjected to excess food intake 16,5 biomedica Oncology 2 ‐ Translational Clinical € 499.400,00 1355 RF‐2009‐1529700 Optimization of the early diagnosis of hepatic encephalopathy at a minimal stage, inquire on its clinical and biochemical correlates, educational perspectives for rehabilitation techniques. Acronym: E.D.U.C.A.T.IO.N. STUDY 16,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 320.000,00 1356 GR‐2009‐1583897 Use of protective cultures for the prevention and treatment of mastitis in small ruminants as an alternative to antibiotics 16,5 biomedica Veterinary ‐ Animal welfare ‐ ANWE € 580.000,00 1357 RF‐2009‐1543150 Host immune system behavior during standard of care chemotherapy in cancer patients: role of regulatory T cells in patient immune response and clinical outcome 16,5 clinico assistenziale Immunology 1358 RF‐2009‐1539587 Targeting the Hodgkin Lymphoma microenvironment by CXCR4 inhibition: overcoming resistance to therapy. 16,5 biomedica Oncology 1 ‐ Basic Translational € 300.000,00 1359 RF‐2009‐1549640 GENOMIC AND PROTEOMIC ALTERATIONS IN HUMAN HEPATOCELLULAR CARCINOMA FROM THE SOUTH OF ITALY: INSIGHTS INTO PROGNOSIS AND CLINICAL MANAGEMENT IN RELATION TO ETIOLOGY AND METABOLIC RISK FACTORS 16,5 biomedica Genes, Genomes and Genetics € 550.640,00 1360 RF‐2009‐1536694 Correlation between redox status and markers of risk and progression of melanoma 16,5 biomedica Musculoskeletal, Oral and Skin Sciences € 600.000,00 1361 RF‐2009‐1543219 A clinical standardized model to fenotype COPD patients and to assess disease severity 16,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 412.500,00 € 150.000,00 Pagina 119 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1362 RF‐2009‐1547398 3 Tesla vs 7 Tesla MRI comparison in the evaluation of cerebral and cerebellar cortex in healthy adults. 16,5 biomedica Bioengineering Sciences and Technologies € 200.000,00 1363 RF‐2009‐1547140 REFERENCE MODELS IN RADIOLOGICAL TECHNOLOGIES AND PRACTICES (REMORA) 16,5 clinico assistenziale Healthcare Delivery and Methodologies € 594.000,00 1364 RF‐2009‐1537144 Immunological and virological effects of maraviroc vs raltegravir vs efavirenz in combination with emcitrabin/tenofovir in the treatment of ART‐naïve HIV‐ infected patients 16,5 clinico assistenziale AIDS and Related Research € 143.000,00 1365 RF‐2009‐1548508 Inflammatory signaling, aging and neurodegenerative diseases: preclinical and clinical investigation 16,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 475.000,00 1366 RF‐2009‐1545272 Use of the Tat protein to develop vaccines and therapeutic interventions 16,5 biomedica AIDS and Related Research € 586.000,00 1367 RF‐2009‐1544980 Appropriateness of diagnosis and immunotherapy of allergic diseases: Immunochemical methods in improving mould allergenic extracts characterization and standardization. 16,5 biomedica Immunology € 595.555,00 1368 RF‐2009‐1503098 Identification of new molecular targets for the development of alternative therapeutic approaches to reduce tumor recurrence 16,5 biomedica Oncology 1 ‐ Basic Translational € 599.500,00 1369 RF‐2009‐1494025 The neuron‐glia cross‐talk in the recruitment and function of glial cells. Role of the novel neuronal signal hyccin. 16,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 400.000,00 1370 RF‐2009‐1504733 Identification of clinically relevant fingerprints of lung cancer by a novel proteomic/peptidomic platform 16,5 biomedica Oncology 2 ‐ Translational Clinical € 180.000,00 1371 RF‐2009‐1498972 Brain death organ donors: Improving the number and quality of organs for transplantation 16,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 280.000,00 1372 RF‐2009‐1498880 Improving the diagnosis of selected rare diseases and rare tumors: MicroRNAs as emerging biomarkers 16,5 biomedica Oncology 2 ‐ Translational Clinical € 599.500,00 Pagina 120 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1373 RF‐2009‐1505010 Innovative strategies to analyze protein‐drug interaction based on structural and computational methods 16,5 biomedica Biological Chemistry and Macromolecular Biophysics € 216.100,00 1374 GR‐2009‐1505378 Effects of low dose mixture of thyroid disruptors in critical phases of development: a translational approach 16,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 511.500,00 1375 RF‐2009‐1468457 Molecular mechanisms for senataxin induced motor neuron degeneration: cellular and animal models. 16,5 biomedica Brain Disorders and Clinical Neuroscience 1376 RF‐2009‐1486229 The role of Dbl in the development of diffuse large B cell lymphoma: molecular and biologic characterization. 16,5 biomedica Oncology 1 ‐ Basic Translational 1377 RF‐2009‐1475162 Tracing of antimicrobial resistance genes in food: a tool for consumer's health risk assessment 16,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 596.470,60 1378 GR‐2009‐1472753 Role of cardiac progenitor cells in doxorubicin induced cardiomyopathy 16,5 biomedica Cardiovascular and Respiratory Sciences € 305.000,00 1379 RF‐2009‐1476085 GMP‐implementation and pre‐clinical validation of cardiac stromal cells for heart repair. 16,5 biomedica Cardiovascular and Respiratory Sciences € 477.000,00 1380 RF‐2009‐1471309 Regenerative medicine and biosafety: development of a microarray‐based screening for transformation risk of in vitro expanded cells. 16,5 biomedica Musculoskeletal, Oral and Skin Sciences € 468.050,00 1381 RF‐2009‐1473524 New approach to optimize osseointegration in dental implantology. Stem cells and regenerative therapy. 16,5 biomedica Bioengineering Sciences and Technologies € 420.000,00 1382 RF‐2009‐1473889 Unravelling the molecular basis of infection‐driven lymphoma 16,5 biomedica Oncology 1 ‐ Basic Translational € 485.000,00 1383 RF‐2009‐1474251 Chikungunya virus a new emerging infection. A multidisciplinary study on virus, vector and host immune cells cross‐talk 16,5 biomedica Infectious Diseases and Microbiology € 458.340,00 1384 RF‐2009‐1475640 Endocrine disruptors in the food chain: occurrence in feed and food and effects in vitro of perfluorinated organic compounds and inorganic arsenic 16,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 € 464.000,00 € 166.320,00 Pagina 121 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1385 GR‐2009‐1574645 The mother‐to‐child health flow: gene‐environment interactions in human placenta 16,67 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 599.500,00 1386 RF‐2009‐1502051 The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro and in vivo. 16,67 biomedica Oncology 2 ‐ Translational Clinical € 500.000,00 1387 GR‐2009‐1492216 Deleted in Breast Cancer 1, a new player in the DNA damage response. 16,67 biomedica Oncology 1 ‐ Basic Translational € 539.000,00 1388 RF‐2009‐1491702 Exploiting the osteogenic properties of mesenchymal stem cells for bone structural‐functional repair in hemodialysis patients: role of uremic toxins. 16,7 biomedica Musculoskeletal, Oral and Skin Sciences € 293.180,00 1389 RF‐2009‐1510840 Functional interactomes: spatio‐temporal dynamics and molecular organization of membrane receptors in cancer 16,75 biomedica Biological Chemistry and Macromolecular Biophysics € 300.000,00 1390 RF‐2009‐1530920 Epigenetics/proteomics of osteosarcoma chemoresistance predictive biomarkers and development of therapeutics. 16,75 biomedica Oncology 2 ‐ Translational Clinical € 219.000,00 1391 GR‐2009‐1546816 A multidisciplinary approach for the identification of novel therapeutic treatments for infants and young children affected by respiratory tract infections. 16,75 biomedica Infectious Diseases and Microbiology € 535.900,00 1392 GR‐2009‐1560087 Skin Biopsy morphometry as Outcome measure for Neuropathy in Diabetes: a worldwide validation study. (The SBOND Project) 16,75 biomedica Brain Disorders and Clinical Neuroscience € 262.900,00 1393 RF‐2009‐1539773 Predicting and preventing cardiotoxicity in the era of breast cancer targeted therapy. Novel molecular tools for clinical issue 16,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 405.000,00 1394 RF‐2009‐1530861 Tissue‐specific T and NK cells characterization for adoptive cell therapy of cutaneous and ocular melanoma 16,75 biomedica Oncology 2 ‐ Translational Clinical € 419.000,00 1395 GR‐2009‐1608127 Thymosin Beta 4: a novel marker for prognosis and detection of colorectal cancer 16,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 271.000,00 Pagina 122 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1396 GR‐2009‐1594570 Reproductive function assessment in patients with testicular tumors after oncological treatment 16,75 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 155.000,00 1397 GR‐2009‐1605613 Residual tumor after preoperative chemotherapy in breast cancer as a model to study resistant micrometastatic disease 16,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 276.570,00 1398 GR‐2009‐1604310 Role of abscisic acid (ABA) in the pathogenesis of atherosclerosis and development of anti‐ABA drugs. 16,75 biomedica Cardiovascular and Respiratory Sciences € 263.480,00 1399 GR‐2009‐1591204 Efficacy of new antiretroviral compounds through PK/PG monitoring 16,75 clinico assistenziale Genes, Genomes and Genetics € 387.000,00 1400 GR‐2009‐1591521 Molecular characterization of the cellular players involved in the epithelial‐ mesenchimal transition process underlying idiopathic pulmonary fibrosis. 16,75 biomedica Cardiovascular and Respiratory Sciences € 237.000,00 1401 GR‐2009‐1580258 Molecular Identification of Resistance/Responsiveness Mechanisms to Anti‐VEGF Therapy in Breast Cancer 16,75 biomedica Oncology 2 ‐ Translational Clinical € 570.000,00 1402 GR‐2009‐1607328 Signaling pathway profiling of renal cell carcinoma for targeted therapy 16,75 biomedica Oncology 2 ‐ Translational Clinical € 385.000,00 1403 GR‐2009‐1607157 Gastric SubMucosal Space as a new site for pancreatic islet transplantation in pigs. 16,75 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 597.367,00 1404 GR‐2009‐1606851 Predictive models of genito‐urinary and sexual dysfunction after high dose radiotherapy for prostate cancer 16,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 403.568,00 1405 GR‐2009‐1569624 New immunogenetic parameters to predict graft‐versus‐host‐disease and graft rejection after allogeneic hematopoietic stem cell transplantation for inborn genetic diseases 16,75 biomedica Immunology € 400.000,00 1406 GR‐2009‐1473761 Innovative statistical approaches to identify aetiopathogenetic factors of myopia in 10 Italian genetic isolates. 16,75 biomedica Genes, Genomes and Genetics € 412.485,00 Pagina 123 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1407 RF‐2009‐1470576 LIVER METABOLITE IDENTIFICATION IN HEPATOCELLULAR CARCINOMA BY HIGH RESOLUTION MAGIC ANGLE SPINNING 1 H NMR SPECTROSCOPY 16,75 biomedica Oncology 2 ‐ Translational Clinical € 490.000,00 1408 RF‐2009‐1490642 SEARCHING FOR VALID, RELIABLE AND FAST TOOLS TO DIFFERENTIATE FRESH FROM FROZEN FISH PRODUCTS 16,75 biomedica Veterinary ‐ Food Safety ‐ FOSA € 538.500,00 1409 RF‐2009‐1499422 The role of joint aspiration and intraoperative culture to isolate pathogen organism in infected total knee arthroplasty. 16,75 clinico assistenziale Infectious Diseases and Microbiology € 330.000,00 1410 GR‐2009‐1607614 Easy HIFU: simplified lesion localization for HIFU treatment 16,84 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 298.000,00 1411 RF‐2009‐1505649 Investigation of the role of estrogen receptors in chronic lymphocytic leukemia 16,84 biomedica Oncology 1 ‐ Basic Translational € 516.000,00 1412 GR‐2009‐1530239 Role of Dbl in epithelial cell transformation: search for diagnostic markers and therapeutic targets for epithelial cancers. 16,84 biomedica Oncology 1 ‐ Basic Translational € 500.000,00 1413 GR‐2009‐1511458 A systematic in vitro analysis of early molecular events involved in the amyloidogenesis. 16,84 biomedica Molecular, Cellular, and Developmental Neuroscience € 375.000,00 1414 GR‐2009‐1578728 DO ESTROGENS INFLUENCE BONE METABOLISM THROUGH THE MODUDULATION OF THE IMMUNE RESPONSE? 16,84 biomedica Musculoskeletal, Oral and Skin Sciences 1415 GR‐2009‐1606373 Understanding in vivo the bio‐pathological role of microRNAs: scientific basis for the identification of novel targets and tools for the non‐conventional anticancer therapy of human hepatocellular carcinoma 16,84 biomedica Oncology 1 ‐ Basic Translational € 410.000,00 1416 RF‐2009‐1475026 Metabolomics of sebum: a new approach to investigate the pathological mechanisms underlying acne. 16,84 biomedica Musculoskeletal, Oral and Skin Sciences € 600.000,00 1417 RF‐2009‐1469979 New approches to prevent or rescue antineoplastic induced cardiomyopathy: from growth factors to cardiac progenitor cell therapy 16,84 biomedica Cardiovascular and Respiratory Sciences € 305.000,00 1418 RF‐2009‐1512248 Sensitivity and resistance of Ph+ leukemias to tyrosine kinase and leukemia stem cell inhibitors 17 biomedica Oncology 1 ‐ Basic Translational € 150.000,00 € 55.000,00 Pagina 124 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1419 GR‐2009‐1591315 Pro‐angiogenic, anti‐angiogenic and inflammatory signals regulating circulating endothelial colony forming cell (ECFC) migration, proliferation and differentiation: impact on lung vascular development after very premature birth 17 biomedica Cardiovascular and Respiratory Sciences € 426.000,00 1420 RF‐2009‐1527530 Niche factors driving hepatic stem cell differentiation toward Hepatic Stellate/Miofibroblast Cells: novel therapeutic targets for liver fibrosis 17 biomedica Cell Biology € 360.000,00 1421 GR‐2009‐1591519 Role of P‐glycoprotein and Multi‐drug resistant 1 for the clinical management of patients HIV positive receiving transplant and treated with antiretroviral and immunosuppressant drugs. 17 biomedica AIDS and Related Research € 243.960,00 1422 GR‐2009‐1591524 Nuclear Pore Complex Genes: towards the Clinical translation of basic results 17 biomedica Oncology 1 ‐ Basic Translational € 525.000,00 1423 GR‐2009‐1604902 EVALUATION OF BRAIN DEVELOPMENT IN FETUSES AND NEWBORNS WITH SEVERE CONGENITAL HEART DISEASE 17 clinico assistenziale Brain Disorders and Clinical Neuroscience € 500.000,00 1424 GR‐2009‐1607878 Analysis of signal transduction pathways involved in haematopoiesis, in the generation and maintenance of leukaemia cell stemness. Identification of novel diagnostic, prognostic and therapeutic targets. 17 biomedica Vascular and Hematology € 331.000,00 1425 GR‐2009‐1591641 MUSCLE IMAGING ASSESSMENT AS A GOLD STANDARD NON INVASIVE TOOL IN ADDRESSING THE DIAGNOSIS OF NEUROMUSCULAR DISORDERS 17 biomedica Musculoskeletal, Oral and Skin Sciences € 310.000,00 1426 RF‐2009‐1530456 A PROSPECTIVE GENETIC STUDY ON PULMONARY SURFACTANT CANDIDATE GENES AND PROTEOMIC ANALYSIS ON BALF IN A SAMPLE OF BRONCHOPULMONARY DYSPLASIA PRETERM EUROPEAN NEWBORNS 17 biomedica Cardiovascular and Respiratory Sciences € 392.000,00 1427 RF‐2009‐1531192 INCIDENCE OF DENTAL PATHOLOGIES AND PREVENTION STRATEGY IN MENTAL RETARDATION FROM RARE PATHOLOGY 17 clinico assistenziale Risk, Prevention and Health Behavior € 167.212,91 1428 GR‐2009‐1559987 Metabolomic profiling and docosahexaenoic acid‐derived anti‐inflammatory mediators in exhaled breath condensate and sputum of adults with cystic fibrosis 17 clinico assistenziale Cardiovascular and Respiratory Sciences € 511.000,00 1429 GR‐2009‐1580046 Molecular biomarkers of response to chemo‐immunotherapy in melanoma patients 17 biomedica Oncology 2 ‐ Translational Clinical € 338.000,00 Pagina 125 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1430 RF‐2009‐1510973 Role of the beta 2 adrenergic receptor in the clinical and molecular setup of the metabolic abnormalities of the failing heart: a positron emission tomography in small animals and humans. 17 biomedica Cardiovascular and Respiratory Sciences € 593.250,00 1431 GR‐2009‐1607217 EFFICACY OF A GROUP‐BASED COGNITIVE‐BEHAVIORAL INTERVENTION FOR PEOPLE WITH SEVERE MENTAL DISORDERS ‐ A RANDOMIZED CONTROLLED TRIAL (THE 4C STUDY) 17 clinico assistenziale Biobehavioral and Behavioral Processes € 259.000,00 1432 RF‐2009‐1528854 Detection of titanium dioxide nanoparticles in food to evaluate toxicity towards humans 17 biomedica Veterinary ‐ Food Safety ‐ FOSA € 407.000,00 1433 RF‐2009‐1511028 Evaluation of DNA methylation status as new biomarker in breast cancer 17 biomedica Oncology 2 ‐ Translational Clinical € 300.000,00 1434 GR‐2009‐1607173 A multidisciplinary approach for neurobiology of Eating Disorders: evaluation of state and trait dependent neural correlates of the core psychopathology, using a combined, MRI, fMRI, and psychiatric assessment, repeated before and after a cognitive behavi 17 clinico assistenziale Biobehavioral and Behavioral Processes € 162.000,00 1435 GR‐2009‐1607191 Alcohol abuse in the adolescent brain: a gate toward addiction? 17 biomedica Molecular, Cellular, and Developmental Neuroscience € 400.000,00 1436 RF‐2009‐1511450 PCSK9 ,plasma LDL, and Atherosclerosis 17 biomedica Cardiovascular and Respiratory Sciences € 275.000,00 1437 RF‐2009‐1548779 Effects of HIV protease inhibitors on in vitro and in vivo experimental models of human uterine cervical tumours 17 biomedica Oncology 1 ‐ Basic Translational € 231.000,00 1438 GR‐2009‐1511031 PROGNOSTIC MODEL IN PATIENTS WITH METASTATIC RENAL CELL CANCER IN TREATMENT WITH SUNITINIB 17 clinico assistenziale Oncology 2 ‐ Translational Clinical € 600.000,00 1439 GR‐2009‐1607194 Identification of the molecular mechanisms through which the mutant p53/Id4 axis controls cytokines production and angiogenesis in breast cancer 17 biomedica Oncology 1 ‐ Basic Translational € 500.000,00 1440 RF‐2009‐1511589 Early cognitive deficit in Alzheimer Disease: segregation of conceptual network 17 clinico assistenziale Brain Disorders and Clinical Neuroscience € 355.007,00 Pagina 126 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1441 RF‐2009‐1528277 Aberrant choline metabolism as a source of imaging biomarkers and pharmacological endpoints for targeted therapies in breast and ovary cancer 17 biomedica Oncology 1 ‐ Basic Translational € 397.000,00 1442 GR‐2009‐1606173 Neuroprotective effects of flavocoxid in Alzheimers disease: an in vitro and in vivo study 17 biomedica Brain Disorders and Clinical Neuroscience € 359.000,00 1443 RF‐2009‐1529895 New bio‐markers for the clinical surveillance of workers previously exposed to asbestos. 17 biomedica Oncology 2 ‐ Translational Clinical € 388.700,00 1444 GR‐2009‐1570265 Preventing onset of synaptic degeneration in early‐stage of Alzheimer disease 17 biomedica Brain Disorders and Clinical Neuroscience € 596.200,00 1445 RF‐2009‐1506170 Advanced phylogenetic analysis in the study of molecular evolution and the surveillance of viral infection. 17 biomedica Healthcare Delivery and Methodologies € 385.000,00 1446 GR‐2009‐1607595 Circulating myeloid subset as tool to predict microenvironment composition in Hodgkin`s Lymphoma: identification of new molecular targets for anti‐neoplastic immunity. 17 biomedica Oncology 2 ‐ Translational Clinical € 325.000,00 1447 RF‐2009‐1509090 Ex‐vivo selection, characterization and amplification of antitumor T‐cell lines from patients with ovarian cancer and metastatic colorectal carcinoma for adoptive immunotherapy 17 biomedica Oncology 2 ‐ Translational Clinical € 188.889,00 1448 GR‐2009‐1567083 Membrane transporters and ion channels in chemoresistance: detection and prognostic significance in acute lymphoblastic leukemia. 17 biomedica Oncology 1 ‐ Basic Translational € 300.000,00 1449 RF‐2009‐1527816 NONCODING RNA IN BRAIN FUNCTION 17 biomedica Molecular, Cellular, and Developmental Neuroscience € 300.000,00 1450 GR‐2009‐1606618 Development of alternative analytical methods for the detection of irradiation treatment in poultry meat and shrimps 17 biomedica Veterinary ‐ Food Safety ‐ FOSA € 295.000,00 1451 GR‐2009‐1528663 Molecular mechanisms of RTN‐1C function: role in CNS disorders. 17 biomedica Molecular, Cellular, and Developmental Neuroscience € 500.000,00 1452 RF‐2009‐1528793 Role of lymphangiogenesis in growth, progression and metastasis of human neuroblastoma 17 biomedica Oncology 1 ‐ Basic Translational € 274.752,00 Pagina 127 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1453 GR‐2009‐1580480 ROLE OF LIVER PLASMACYTOID DENDRITIC CELLS IN LIVER ISCHEMIA/REPERFUSION INJURY 17 biomedica Immunology € 575.900,00 1454 GR‐2009‐1606808 Investigating the role of Bcl‐2/adenovirus E1B 19‐kDa interacting protein (BNip3) in mitochondrial dysfunction in Huntington's disease 17 biomedica Molecular, Cellular, and Developmental Neuroscience € 450.000,00 1455 RF‐2009‐1535149 Critical issues of late preterm births: improving appropriateness and standard of cares 17 clinico assistenziale Healthcare Delivery and Methodologies € 360.000,00 1456 GR‐2009‐1604487 Use of stromal cells isolated from bone marrow fat (BMFC) to treat the animal model of multiple sclerosis (EAE). A preclinical study. 17 biomedica Brain Disorders and Clinical Neuroscience € 285.000,00 1457 GR‐2009‐1594621 Phenotype, genotype and pharmacological dissection of mTOR pathway for the identification of druggable molecules in high‐grade osteosarcoma. 17 biomedica Oncology 1 ‐ Basic Translational € 391.000,00 1458 RF‐2009‐1538868 MicroRNAs Gene Expression Profiling of rejection/infection in solid organ transplantation in children 17 biomedica Immunology € 594.000,00 1459 RF‐2009‐1547701 VARIATIONS IN CANCER CARE ACROSS ITALY 17 clinico assistenziale Healthcare Delivery and Methodologies € 482.350,00 1460 RF‐2009‐1525767 Study of mechanisms involved in the protective effect of physical exercise on age‐ dependent cognitive impairment 17 biomedica Biology of Development and Aging € 372.000,00 1461 GR‐2009‐1608333 Genetic variants involved in the susceptibility to MGUS, at risk of transition to SMM and MM. 17 biomedica Oncology 1 ‐ Basic Translational € 260.500,00 1462 GR‐2009‐1594613 Neuroinflammation and synaptic function: an electrophysiological analysis in experimental multiple sclerosis 17 biomedica Molecular, Cellular, and Developmental Neuroscience € 437.000,00 1463 RF‐2009‐1523736 Treatment with intra‐erythrocyte encapsulated Dexamethasone sodium‐ phosphate in cystic fibrosis patients with double lung transplantation 17 clinico assistenziale Immunology € 464.000,00 1464 RF‐2009‐1550631 Circulating microRNA signatures as novel noninvasive biomarkers for breast cancer 17 biomedica Oncology 2 ‐ Translational Clinical € 456.500,00 Pagina 128 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1465 RF‐2009‐1547697 Impacting on microglia behavior through mesenchymal stem cells: implications for the treatment of multiple sclerosis 17 biomedica Brain Disorders and Clinical Neuroscience 1466 RF‐2009‐1546812 Evaluation of HIV‐1 Tat protein at physiologically hypoxic conditions: impact on HIV‐1 infection and immune responses 17 biomedica AIDS and Related Research € 519.500,00 1467 GR‐2009‐1595979 Study of HIV‐1 regulatory mechanisms mediated by Tat 17 biomedica AIDS and Related Research € 333.330,00 1468 RF‐2009‐1550475 START STATE OF THE ART ONCOLOGY IN EUROPE A COMPREHENSIVE EVIDENCE‐BASED DATABASE ON MALIGNANT TUMOURS IN SUPPORT OF HEALTH CARE PROFESSIONALS IN DAILY ONCOLOGY PRACTICE AND PATIENT ADDRESSED INFORMATION 17 clinico assistenziale Healthcare Delivery and Methodologies € 475.200,00 1469 RF‐2009‐1524345 Neuroinflammation in Alzheimer's disease 17 biomedica Immunology € 408.650,00 1470 GR‐2009‐1595814 The role of gene profiling: tissue and circulating markers in the prediction of bone metastases in breast cancer patients 17 biomedica Oncology 2 ‐ Translational Clinical € 345.000,00 1471 GR‐2009‐1521702 D‐Aspartate: an atypical amino acid with therapeutic potential in cognitive disorders 17 biomedica Molecular, Cellular, and Developmental Neuroscience € 505.000,00 1472 RF‐2009‐1521812 Genome wide analysis (GWA) in RET wild type hereditary and sporadic medullary thyroid cancer to identify either new oncogenic alterations or chromosomal regions of interest linked to the tumoral disease 17 biomedica Genes, Genomes and Genetics € 550.000,00 1473 RF‐2009‐1549730 GEMCART: a randomized phase II trial with Carboplatinum and Gemcitabine and their combination with Trastuzumab in HER2 ‐ positive metastatic breast cancer patients pretreated with Trastuzumab and Lapatinib. 17 clinico assistenziale Oncology 2 ‐ Translational Clinical € 225.000,00 1474 GR‐2009‐1608064 Production of human pluripotent cells by chemical reprogramming 17 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 506.500,00 1475 GR‐2009‐1596492 High‐resolution pharmacogenetic profiles of genes involved in drug absorption, distribution, metabolism and elimination in adult acute lymphoblastic leukemia patients to optimize current and novel therapies 17 biomedica Genes, Genomes and Genetics € 160.000,00 € 526.960,00 Pagina 129 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1476 GR‐2009‐1604441 Cutaneous squamous cell carcinoma (CSCC) and precursor lesions: role of cutaneous HPV infection, gene/protein profiling and investigation of novel prognostic markers 17 biomedica Oncology 1 ‐ Basic Translational € 480.000,00 1477 GR‐2009‐1608832 Angiogenesis as therapeutic target in glioblastoma: study of predictive and/or prognostic tissue markers, mechanisms of action and effects. 17 clinico assistenziale Oncology 2 ‐ Translational Clinical € 302.500,00 1478 GR‐2009‐1608817 Development of an immunological based strategy against membrane proteins involved in human cancer: a potential diagnostic and clinical application 17 biomedica Oncology 2 ‐ Translational Clinical € 551.000,00 1479 GR‐2009‐1594924 Guided immunomodulation of stroke activated blood borne inflammatory cells as a novel therapeutic rationale to limit brain infiltration and neuronal damage in the ischemic penumbra in mammals 17 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 1480 RF‐2009‐1475005 Definition of new immunological and biochemical biomarkers of diagnostic, prognostic and therapeutic value in the management of Kawasaki disease 17 biomedica Immunology € 580.000,00 1481 RF‐2009‐1469176 Role of lipofuscin in the pathogenesis of Alzheimer's disease 17 biomedica Brain Disorders and Clinical Neuroscience € 286.000,00 1482 RF‐2009‐1475531 Novel combination therapies based on Reverse Transcriptase inhibitors for cancer treatment of improved efficacy 17 biomedica Oncology 1 ‐ Basic Translational € 588.462,00 1483 RF‐2009‐1487484 "Animal models of neuroferritinopathies: new genetic models to study the role of iron in neurodegeneration" 17 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 1484 RF‐2009‐1491719 Neurotoxins in bladder and prostate cancer: new potential agents for chemotherapy 17 biomedica Oncology 1 ‐ Basic Translational € 385.200,00 1485 RF‐2009‐1498813 Molecular Mechanism of Cancer Prevention: The Psoriasis Model 17 clinico assistenziale Oncology 1 ‐ Basic Translational € 600.000,00 1486 RF‐2009‐1474056 Mesenchymal cells in the hematopoietic stem cell transplantation setting: evaluation of immunomodulatory function, impact on hematopoietic recovery and on leukemic cell survival. 17 clinico assistenziale Vascular and Hematology € 270.000,00 1487 RF‐2009‐1475400 A functional genomic approach to overcome drug resistance in ovarian cancer 17 biomedica Oncology 1 ‐ Basic Translational € 561.000,00 Pagina 130 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1488 RF‐2009‐1468690 DISORDERS WITH ANOMALOUS OSSIFICATION: PROOF OF PRINCIPLE FOR NEW THERAPEUTIC APPROACHES 17 biomedica Genes, Genomes and Genetics € 405.000,00 1489 RF‐2009‐1483309 Engineering Intestinal Probiotics with IgE Moieties to Establish a Universal Fight Against Allergy 17 biomedica Digestive, Kidney and Urological Systems € 300.000,00 1490 RF‐2009‐1476123 Identification of prognostic molecular markers in Wilms tumor through genome‐ wide approaches 17 biomedica Oncology 1 ‐ Basic Translational € 240.900,00 1491 RF‐2009‐1468834 INHERITED THROMBOCYTOPENIAS: FROM GENES TO DRUGS THROUGH IN VITRO MODELS 17 biomedica Vascular and Hematology € 495.000,00 1492 RF‐2009‐1483277 Epithelial ovarian cancer: cancer stem cell, tumor microenvironment and in vitro response to drugs. 17 biomedica Oncology 1 ‐ Basic Translational € 534.000,00 1493 RF‐2009‐1539799 Development of novel molecules and medical devices for the treatment of wet age‐ related macular degeneration 17,17 biomedica Cell Biology € 600.000,00 1494 GR‐2009‐1594727 Role of MicroRNAs and Ultraconserved Regions in the pathogenesis and treatment of Renal Cell Carcinoma 17,17 biomedica Oncology 1 ‐ Basic Translational € 350.500,00 1495 RF‐2009‐1510834 Hepatocellular carcinoma and glioblastoma induce abnormal vascular organization: study on the role of their tumor‐infiltrating stromal cells. 17,17 biomedica Oncology 1 ‐ Basic Translational € 254.500,00 1496 GR‐2009‐1528298 Emerging viral pathogens of carnivores and possible risks for human health 17,17 biomedica Veterinary ‐ Animal Health ‐ ANHE € 387.500,00 1497 RF‐2009‐1546688 TUMOR INITIATING CELLS AND THEIR MICROENVIRONMENT IN ACUTE MYELOID LEUKEMIA. CHARACTERIZATION AND TARGETING 17,17 biomedica Oncology 1 ‐ Basic Translational € 407.800,00 1498 RF‐2009‐1506133 PROJECT: Role of B cell receptor signaling in CLL: prognostic relevance and new therapeutic strategies 17,17 biomedica Oncology 1 ‐ Basic Translational € 250.000,00 1499 RF‐2009‐1475609 Study of ADAM17/TACE as a therapeutic target in epithelial ovarian cancer 17,17 biomedica Oncology 1 ‐ Basic Translational € 150.000,00 1500 GR‐2009‐1606681 Clinical validation of an high sensitivity HIV‐RNA test. 17,25 biomedica AIDS and Related Research € 244.000,00 Pagina 131 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1501 GR‐2009‐1606694 Mesenchymal stem cells in the treatment of ALS: from bench to bedside 17,25 biomedica Brain Disorders and Clinical Neuroscience € 301.000,00 1502 GR‐2009‐1596785 EPIDEMIOLOGY OF HBV AND HCV INFECTIONS IN SICILY: MONITORING THROUGH MOLECULAR CHARACTERIZATION OF THE VIRAL STRAINS 17,25 biomedica Infectious Diseases and Microbiology € 195.000,00 1503 RF‐2009‐1531267 Feasibility and accuracy of robotic colonoscopy with minimally invasive colon preparation. 17,25 clinico assistenziale Digestive, Kidney and Urological Systems € 400.000,00 1504 GR‐2009‐1579647 Bisphosphonate‐related osteonecrosis of the jaws and genetic polymorphism: a genetic study 17,25 biomedica Oncology 2 ‐ Translational Clinical € 322.000,00 1505 GR‐2009‐1580494 Multidisciplinary novel approach to early detection of atherosclerotic plaque formation and progression: analysis of new biocompatible molecular imaging probes and biomarkers 17,25 biomedica Cardiovascular and Respiratory Sciences € 545.000,00 1506 RF‐2009‐1530060 Role of stress echocardiography in valvular heart disease 17,25 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering 1507 RF‐2009‐1538301 In‐vivo prognostication of posterior uveal melanoma: a combined cytogenetic and circulating tumor cells approach. 17,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 273.000,00 1508 RF‐2009‐1548334 MOVEMENT OBSERVATION EMPOWERS NEUROPLASTIC REORGANIZATION OF MOTOR NETWORKS AND ENHANCES RECOVERY FROM STROKE 17,25 biomedica Brain Disorders and Clinical Neuroscience € 570.000,00 1509 GR‐2009‐1603070 THE DNA "METHYLOME" OF HUMAN CUTANEOUS MELANOMA: PROGNOSTIC, CLINICAL AND IMMUNOTHERAPEUTIC IMPLICATIONS 17,25 biomedica Oncology 2 ‐ Translational Clinical € 574.000,00 1510 GR‐2009‐1580634 Investigation of the expression profile and role of Caveolin‐1 in rhabdomyosarcoma tumors 17,25 biomedica Oncology 1 ‐ Basic Translational € 290.000,00 1511 RF‐2009‐1501945 Early detection of lung cancer in high‐risk population: an integrated bio‐imaging and bio‐molecular approach 17,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 599.500,00 1512 GR‐2009‐1472563 Double‐blinded, sham‐controlled, randomized study to evaluate the efficacy and safety of premotor cortical stimulation in focal hand dystonia 17,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 315.700,00 € 152.300,00 Pagina 132 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1513 RF‐2009‐1494697 Pathogenic simian/human immunodeficiency virus with genetic changes after passage from rhesus to cynos: genetic pathway of transmitted /founder viruses and impact of the MHC class I in a cohort of cynomolgus monkeys. 17,25 biomedica AIDS and Related Research € 325.000,00 1514 RF‐2009‐1504230 New discovery approaches for the non‐invasive early diagnosis of lung cancer 17,25 biomedica Oncology 2 ‐ Translational Clinical € 599.500,00 1515 RF‐2009‐1473058 MOLECULAR GENETIC AND PHENOTYPIC EXPRESSION OF MONOGENIC HYPERTRIGLYCERIDEMIAS 17,25 biomedica Genes, Genomes and Genetics € 445.000,00 1516 RF‐2009‐1505083 Evaluation of the immune response against human papillomavirus induced by prophylactic vaccination and after natural infection aiming to identify immune correlates of protection 17,25 clinico assistenziale Immunology € 534.000,00 1517 RF‐2009‐1488665 Non invasive prenatal diagnosis of genetic diseases by separation and enrichment of circulating fetal cells in maternal blood 17,25 biomedica Genes, Genomes and Genetics € 166.080,00 1518 GR‐2009‐1471730 Assessing short and long term comparative effectiveness of PCI vs. CABG: an observational outcome study using administrative data 17,25 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 1519 RF‐2009‐1499817 CAUSES AND CONSEQUENCES OF FETAL PROGRAMMING OF SOMATIC, KIDNEY, AND LIVER GROWTH AFTER BIRTH. A BIOCHEMICAL, GENETIC AND SYSTEMS BIOLOGY APPROACH AND AN ECONOMIC EVALUATION. 17,3 biomedica Biology of Development and Aging € 442.000,00 1520 GR‐2009‐1608506 Systematic assessment of the acute and chronic effects of trauma on quality of life 17,34 biomedica Integrative, Functional, and Cognitive Neuroscience € 600.000,00 1521 GR‐2009‐1608007 Identifying novel genetic and molecular determinants of bone health and disease 17,34 biomedica Musculoskeletal, Oral and Skin Sciences € 600.000,00 1522 RF‐2009‐1535330 Low grade inflammatory status, sleep apnea syndrome and endocrine andrologic dysfunctions in patients with morbid obesity: Role of specific profiles of circulating chemokines and type of macrophage activation sustaining chronic inflammation and its relati 17,34 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 350.000,00 1523 RF‐2009‐1491745 Neuroprotective activity of transmembrane chemokines CX3CL1 and CXCL16 in experimental models of brain ischemia and Parkinson disease. 17,34 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 Pagina 133 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1524 GR‐2009‐1607344 Evaluation of the role of oxytocin in the placebo effect 17,5 biomedica Integrative, Functional, and Cognitive Neuroscience € 800.000,00 1525 RF‐2009‐1547517 Fragility and myelomatous fractures: bone quality, bone healing and therapy 17,5 clinico assistenziale Biology of Development and Aging € 303.000,00 1526 RF‐2009‐1534814 Neonatal Thyroid function and phthalates exposure ‐ NeThyPhEx 17,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 593.444,00 1527 GR‐2009‐1575073 A multidisciplinary approach to the study of Spatial Awareness in brain tumor and stroke: from a better diagnosis to the recovery/prevention of the deficits. 17,5 biomedica Brain Disorders and Clinical Neuroscience € 597.000,00 1528 GR‐2009‐1608994 Characterization of Circulating Tumor Cells in patients with advanced breast cancer 17,5 biomedica Oncology 2 ‐ Translational Clinical € 420.000,00 1529 RF‐2009‐1511331 Remyelination failure in multiple sclerosis: to understand the mechanism and overcome the differentiation block of resident and newly generated oligodendrocyte precursor cells. 17,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 457.000,00 1530 RF‐2009‐1544597 Evaluation of the rough strain Brucella melitensis B115 as a vaccine against brucellosis 17,5 biomedica Veterinary ‐ Animal Health ‐ ANHE € 440.000,00 1531 GR‐2009‐1580010 Effects of in vitro nutrient supplementations on inflammation and zinc homeostasis modulation as prospective for nutrigenetic interventions in atherosclerosis and type 2 diabetes. 17,5 biomedica Vascular and Hematology € 600.000,00 1532 GR‐2009‐1608440 Early non invasive diagnosis and prognostic biological profiles of bladder cancer: from laboratory to clinic 17,5 biomedica Oncology 2 ‐ Translational Clinical € 350.000,00 1533 GR‐2009‐1608741 EXTENDING REHABILITATION FROM HOSPITAL TO HOME WITH WEARABLE DEVICES 17,5 biomedica Musculoskeletal, Oral and Skin Sciences € 500.000,00 1534 RF‐2009‐1506106 Developmental exposure to environmental toxicants and risk of Autism Spectrum Disorders: an integrated in vivo and in vitro approach to unravel the molecular mechanisms involved in the neuroendocrine and behavioral effects of organophosphorous pesticides 17,5 biomedica Integrative, Functional, and Cognitive Neuroscience € 577.333,00 Pagina 134 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1535 GR‐2009‐1591643 Platelet transcriptomics and gene expression profiling as a tool to predate myocardial infarction 17,5 biomedica Cardiovascular and Respiratory Sciences € 591.000,00 1536 GR‐2009‐1578121 Genetic diversity, phylogenetic analyses and phylodinamic of HCV from plasma, PBMC and liver tissue in patients of the Mediterranean area 17,5 biomedica Healthcare Delivery and Methodologies € 385.000,00 1537 RF‐2009‐1539451 Lexical semantic skills, APOE and neuroanatomical substrate of semantic memory in early diagnosis of Alzheimer's disease 17,5 clinico assistenziale Biobehavioral and Behavioral Processes € 284.120,00 1538 RF‐2009‐1530237 Characterization of the impact of co‐infections by hepatitis viruses on the anti‐ viral immune response and disease progression in HIV‐infected individuals from Subsaharian Africa. 17,5 clinico assistenziale AIDS and Related Research € 500.000,00 1539 GR‐2009‐1547692 Mechanisms Of Stent Thrombosis (MOST) Study 17,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 449.000,00 1540 GR‐2009‐1608307 UnderstaNding the mechanisms of vitamin D Effects on musculaR STrength and PerformANce in elDers (UNDERSTAND) 17,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 400.000,00 1541 GR‐2009‐1605042 RANK‐L/RANK‐OPG pathway as novel target in induced‐bone loss disease: from rheumatoid arthritis to osteoporosis. 17,5 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 447.500,00 1542 GR‐2009‐1578363 Identification of lung cancer associated oncoantigens as target for active immunotherapy 17,5 biomedica Immunology € 450.000,00 1543 GR‐2009‐1596663 The role of iconic memory in developmental dyslexia 17,5 biomedica Brain Disorders and Clinical Neuroscience € 231.000,00 1544 RF‐2009‐1528953 Carboplatin and Pemetrexed chemotherapy in malignant mesothelioma Italians patients: impact of the C1900T ERCC1 and TSER* genotype on response to chemotherapy, clinical outcome and toxicity. 17,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 232.500,00 1545 GR‐2009‐1596768 Novel RNase‐based antitumor agents 17,5 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 Pagina 135 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1546 GR‐2009‐1575518 Amyotrophic Lateral Sclerosis neuro‐muscular degeneration shares pathological features with Spinal and Bulbar Muscular Atrophy: study of the Androgen Receptor‐dependent machanism(s) in cellular toxicity and analysis of the possible implications of "dopin 17,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 134.000,00 1547 GR‐2009‐1578806 TUMOR‐ AND VASCULAR‐TARGETED THERAPIES AGAINST PEDIATRIC AND ADULT SOLID CANCERS 17,5 biomedica Oncology 2 ‐ Translational Clinical € 312.660,00 1548 RF‐2009‐1536336 SPECIFIC READING DISORDERS: EARLY IDENTIFICATION AND INTERVENTION ON AT‐RISK CASES THROUGH INTERNET‐BASED, SELF‐ PACING SYSTEMS, REMOTELY SUPERVISED 17,5 clinico assistenziale Healthcare Delivery and Methodologies € 258.000,00 1549 RF‐2009‐1544916 Wound‐healing and vasculogenic mimicry as players of early relapse in triple negative breast carcinomas 17,5 biomedica Oncology 1 ‐ Basic Translational € 500.500,00 1550 GR‐2009‐1606087 Cryptic chromosomal imbalances analysis in patients with Idiopathic Generalized Epilepsy through high‐resolution array‐CGH 17,5 biomedica Brain Disorders and Clinical Neuroscience € 535.000,00 1551 RF‐2009‐1529701 Physician group management of chronic viral hepatitis: value index of personalized antiviral therapy 17,5 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 1552 RF‐2009‐1534778 HEALTHY SPINE: A PERSPECTIVE, RANDOMIZED, CONTROLLED, BLIND TRIAL APPLIED TO AN INTEGRATIVE APPROACH WITH BACK SCHOOL AND SHIATSU, FOR HEALTHCARE STAFF. 17,5 clinico assistenziale Healthcare Delivery and Methodologies € 217.000,00 1553 GR‐2009‐1511126 Role of astrocytic inwardly‐rectifying K+ channels in the pathogenesis of Autism Spectrum Disorders with susceptibility to seizures (Autism‐Epilepsy Phenotype). 17,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 499.070,00 1554 RF‐2009‐1524541 IDENTIFICATION OF NEW PREDISPOSING ALLELES IN HEREDITARY BREAST AND OVARIAN CANCER FAMILIES WITH A NON‐INFORMATIVE BRCA1/2 TEST 17,5 biomedica Genes, Genomes and Genetics € 330.500,00 1555 GR‐2009‐1580288 PET, serum tumour markers and circulating tumour cells in early treatment efficacy assessment for patients with advanced non‐small cell lung cancer (NSCLC) 17,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 460.000,00 1556 RF‐2009‐1547128 Cancer stem cells and hematopoietic growth factors: a dangerous liaison? 17,5 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 Pagina 136 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1557 RF‐2009‐1537608 Identification of biomarkers for disease prognosis and monitoring in Metachromatic Leukodystrophy (and other lysosomal storage diseases) 17,5 biomedica Brain Disorders and Clinical Neuroscience € 325.000,00 1558 RF‐2009‐1511595 Early use of Extracorporeal Membrane Oxygenation in ARDS (EuECMO) 17,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 510.000,00 1559 GR‐2009‐1606534 The impact of inflammation and multimodal neuroimaging parameters on aphasia recovery prediction in patients with acute ischemic stroke 17,5 biomedica Brain Disorders and Clinical Neuroscience € 365.000,00 1560 GR‐2009‐1567860 Understanding the molecular mechanisms of Heat Shock Protein 90 for the rational discovery of new anticancer molecules: From computational models to in vivo experiments 17,5 biomedica Biological Chemistry and Macromolecular Biophysics € 388.000,00 1561 RF‐2009‐1505386 Circulating tumor cells (CTC) in early mammary breast cancer 17,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 96.000,00 1562 RF‐2009‐1487536 Role of circulating mesenchymal stem cells and sTRAIL in heart failure: a potential approach for regenerative medicine 17,5 biomedica Cardiovascular and Respiratory Sciences € 500.000,00 1563 RF‐2009‐1493983 Muscle functional, structural and molecular correlates of motor disability in obese subjects with Prader‐Willi syndrome. 17,5 biomedica Musculoskeletal, Oral and Skin Sciences € 555.000,00 1564 GR‐2009‐1475210 Epidemiological role of Human Bocavirus in acute respiratory illnesses in Puglia. 17,5 clinico assistenziale Infectious Diseases and Microbiology € 390.000,00 1565 RF‐2009‐1545824 TOWARD PERSONALIZED MEDICINE: INVESTIGATING ANTIDEPRESSANT EFFICACY AND THE UNDERLYING MOLECULAR MECHANISMS IN A GENE BY ENVIRONMENT INTERACTION PERSPECTIVE 17,67 biomedica Biobehavioral and Behavioral Processes € 579.000,00 1566 RF‐2009‐1537598 Generation of disease‐specific RIsk Scores for heritable COnnective tissue Diseases with arterial aneurysm and dissection (RISCOD) 17,67 clinico assistenziale Cardiovascular and Respiratory Sciences € 600.000,00 1567 RF‐2009‐1531953 Transgenic C. elegans as a model for mechanistic studies and the development of innovative therapeutic strategies for Alzheimer disease and peripheral amyloidoses 17,67 biomedica Molecular, Cellular, and Developmental Neuroscience € 578.600,00 1568 RF‐2009‐1546515 Targeting the heparanase/heparansulfate system for pediatric sarcoma therapy 17,67 biomedica Oncology 1 ‐ Basic Translational € 399.300,00 Pagina 137 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1569 RF‐2009‐1531315 Development of a computerized clinical chart and a set of quality indicators to monitor patients with Systemic Lupus Erythematosus (SLE) in routine clinical practice and in observational studies and development of a multicenter lupus network. 17,67 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 154.000,00 1570 RF‐2009‐1536039 BIOCHEMICAL MECHANISMS OF IMMUNOACTIVATION IN HIV INFECTED PATIENTS: THE ROLE OF TAT PROTEIN 17,67 biomedica AIDS and Related Research € 472.000,00 1571 RF‐2009‐1536137 DISTAL MYOPATHIES: MOLECULAR CHARACTERIZATION AND CLINICAL, HISTOPATHOLOGICAL AND MUSCLE IMAGING ASSESSMENT 17,67 biomedica Musculoskeletal, Oral and Skin Sciences € 360.800,00 1572 GR‐2009‐1595997 ASSOCIATION OF CALCA GENE POLYMORPHISMS, OXIDATIVE STRESS, AND ARTERIAL FUNCTION WITH MIGRAINE AND POSSIBLE TREATMENT IMPLICATIONS 17,75 biomedica Brain Disorders and Clinical Neuroscience € 267.000,00 1573 GR‐2009‐1607212 Immune reconstitution after nonmyeloablative allogeneic stem cells transplant and role of thymic‐derived donor T cells in preventing infections and promoting graft‐versus‐tumor effect. 17,75 biomedica Oncology 2 ‐ Translational Clinical € 120.000,00 1574 RF‐2009‐1530518 Impact of cytokine blocking‐therapy on immunological pathways in lesional skin and systemic circulation of patients with psoriasis and psoriatic arthritis. 17,75 biomedica Immunology € 190.000,00 1575 GR‐2009‐1551923 Zoonotic parasitic infections in livestock and humans from zootechnical farms, didactic farms and agritourisms in the Salerno province, Southern Italy 17,75 biomedica Infectious Diseases and Microbiology € 600.000,00 1576 RF‐2009‐1528879 Assessment of the role of image guided hypofractionated intensity modulated radiotherapy in the treatment of prostate, lung and head and neck cancers 17,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 600.000,00 1577 RF‐2009‐1511553 Development of molecular diagnostic strategies and validation of clinical application in Oncology 17,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 246.000,00 1578 GR‐2009‐1569668 Experimental correlation amongst density, static strength and cracking behaviour of sows' bones weakened by an hormonal situation similar to that observed in post‐menopausal women 17,75 biomedica Bioengineering Sciences and Technologies € 569.500,00 1579 RF‐2009‐1521799 Genetic determination of dopamine signaling of cognitive phenotypes related with schizophrenia 17,75 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 Pagina 138 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1580 GR‐2009‐1473229 Off‐label use of antiretroviral drugs in children exposed to HIV‐1: a nation‐wide multicenter study 17,75 clinico assistenziale AIDS and Related Research € 164.000,00 1581 RF‐2009‐1501011 Identification of novel prognostic markers for Hepatitis C virus therapy by quantitative proteomics 17,75 biomedica Infectious Diseases and Microbiology € 330.000,00 1582 RF‐2009‐1471032 Treatment of high risk cervical intraepitelial neoplasia in HIV seronegative women with HIV protease inhibitors: background preparatory studies and phase II clinical trial 17,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 600.000,00 1583 RF‐2009‐1472481 GENETIC MODULATION OF COELIAC DISEASE 17,75 clinico assistenziale Genes, Genomes and Genetics € 312.000,00 1584 RF‐2009‐1493244 Development of multitargeted therapy and identification of predictive biomarkers for the optimization of colorectal cancer treatment: a comprehensive approach combining molecular, functional and prognostic information 17,75 biomedica Oncology 2 ‐ Translational Clinical € 318.000,00 1585 RF‐2009‐1549559 Improving RAAS Blockers prescription on the basis of pharmacoepidemiological and laboratory data 17,84 clinico assistenziale Vascular and Hematology € 524.200,00 1586 GR‐2009‐1606982 Isolation of pluripotent stem cells from murine and human testes for generation of autologous spermatozoa 18 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences 1587 GR‐2009‐1607158 Targeting specific steps of cholesterol biosynthesis to inhibit angiogenesis and tumor progression 18 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 1588 GR‐2009‐1600152 Evaluation of virus‐specific T cell response in patients with occult heptitis B virus infection undergoing immunosoppressive chemotherapy: potential implications for clinical management. 18 biomedica Immunology € 244.000,00 1589 RF‐2009‐1545271 Evaluation of the impact of a Menopausal Womens Health Clinic Network in Chronic Disease Prevention 18 clinico assistenziale Population Sciences and Epidemiology € 583.000,00 1590 GR‐2009‐1607147 Inflammatory stage in post‐operatory patients measured by microdialysis. 18 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 316.000,00 € 394,00 Pagina 139 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1591 GR‐2009‐1592126 GLUTEN ANTAGONIST PEPTIDES AS A NEW THERAPEUTIC STRATEGY IN CELIAC DISEASE 18 biomedica Digestive, Kidney and Urological Systems € 500.000,00 1592 GR‐2009‐1596700 Neuroprotection and modulation of endogenous neurogenesis: role of Neuropeptide Y and estrogens in an in vivo model of hippocampal neurodegeneration. 18 biomedica Brain Disorders and Clinical Neuroscience € 150.000,00 1593 GR‐2009‐1606097 MRI and EEG‐EMG markers for the diagnosis and prognosis in young‐onset torsion dystonia 18 clinico assistenziale Brain Disorders and Clinical Neuroscience € 400.000,00 1594 RF‐2009‐1548916 Evaluation of benefit/risk profile of different antineoplastic regimens administered to elderly cancer patients with advanced stage tumor and polipathology to simplify medical interventions. 18 clinico assistenziale Oncology 2 ‐ Translational Clinical € 165.000,00 1595 RF‐2009‐1527195 The role of microRNAs in T‐cell physiology and neoplastic transformation. 18 biomedica Immunology € 510.000,00 1596 RF‐2009‐1531299 DIAGNOSTIC, CLINICAL AND GENETIC CORRELATES OF ENDOPHENOTYPES IN ANOREXIA NERVOSA: COGNITION AND NEURAL CONNECTIVITY 18 clinico assistenziale Brain Disorders and Clinical Neuroscience € 585.000,00 1597 RF‐2009‐1547675 A translational approach to the oxidative stress burden in end‐stage renal disease 18 clinico assistenziale Population Sciences and Epidemiology € 600.000,00 1598 GR‐2009‐1577937 Brain and ketogenic diets: unsuspected potentialities during aging 18 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 600.000,00 1599 RF‐2009‐1543811 In vitro and ex vivo studies of Electromagnetic Fields' effects on stem cells and risk assessment of health care workers 18 biomedica Healthcare Delivery and Methodologies € 550.000,00 1600 GR‐2009‐1591846 Targeted chemotherapy for osteosarcoma: biointegrated nanoparticles as a forthcoming therapeutic strategy 18 biomedica Oncology 2 ‐ Translational Clinical € 400.000,00 1601 GR‐2009‐1535004 Experimental studies and preclinical applications of stem cells from amniotic fluid: new perspectives for the treatment of neurological and orthopedic diseases. 18 biomedica Cell Biology € 547.800,00 1602 RF‐2009‐1547354 Suppression of epitope spreading with inhibitors of PARP‐1 and its relevance to treatment of multiple sclerosis 18 biomedica Brain Disorders and Clinical Neuroscience € 155.000,00 Pagina 140 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1603 GR‐2009‐1580564 CONDITIONAL MOUSE MODELS FOR THE STUDY OF THE WNT/BETA‐ CATENIN PATHWAY IN CEREBELLAR DEVELOPMENT AND MEDULLOBLASTOMA FORMATION 18 biomedica Biology of Development and Aging 1604 RF‐2009‐1536157 Transplant of Placenta Derived Cells as a Potential Anti‐proliferative treatment in animal models of cancer 18 biomedica Oncology 2 ‐ Translational Clinical 1605 RF‐2009‐1523279 Evaluation of the antiviral role of Immunogenic Complexes in woodchucks with chronic WHV infection. Analysis of virological and immunological correlates for identifying new therapeutic strategies for HBV chronic liver disease 18 biomedica Infectious Diseases and Microbiology € 385.000,00 1606 GR‐2009‐1606799 Exploring the role of the Na+/Ca+2 exchanger in the dysregulation of oligodendrocyte differentiation to establish new therapeutic strategies to control demyelination and astrogliosis in Multiple Sclerosis and other demyelinating diseases 18 biomedica Molecular, Cellular, and Developmental Neuroscience € 417.000,00 1607 RF‐2009‐1524470 REHABILITATION OF VISUAL AND SPATIAL DISORDERS THROUGH MULTISENSORY AND TRANSCRANIAL DIRECT CURRENT STIMULATION 18 clinico assistenziale Integrative, Functional, and Cognitive Neuroscience € 330.000,00 1608 RF‐2009‐1511940 Defining the rational basis for an epigenetic therapy of malignant gliomas: the role of histone H3 lysine 27 methylation 18 biomedica Oncology 1 ‐ Basic Translational € 590.556,00 1609 GR‐2009‐1592284 Inside the 14‐3‐3 proteins and their interactomes: a reverse proteomic approach to define protein functions in Apicomplexan parasites and identify novel potential drug targets. 18 biomedica Infectious Diseases and Microbiology € 357.500,00 1610 GR‐2009‐1591773 Role of phospholipid‐scramblase 1 in immunogenic cancer cell death. 18 biomedica Oncology 1 ‐ Basic Translational 1611 GR‐2009‐1607161 Metabolic disruption: molecular mechanisms, detection and clinical implications in human health 18 biomedica Biological Chemistry and Macromolecular Biophysics 1612 RF‐2009‐1546449 INNOVATIVE THERAPEUTIC STRATEGIES AND PROGNOSTIC FACTORS IN UNDIFFERENTIATED THYROID CARCINOMA 18 biomedica Oncology 1 ‐ Basic Translational € 374.600,00 1613 GR‐2009‐1595427 Lipid specific CD1‐restricted T cell response in the pathogenesis of Crohn's Disease 18 biomedica Immunology € 427.700,00 € 399.300,00 € 415.277,00 € 400.000,00 € 573.100,00 Pagina 141 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1614 RF‐2009‐1528950 How chronic infections contribute to progression of aging: from immune activation to telomere shortening and cellular senescence 18 clinico assistenziale Biology of Development and Aging 1615 GR‐2009‐1607182 Metabolically‐normal and metabolically‐abnormal obesity: effects of overfeeding 18 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 493.688,00 1616 GR‐2009‐1605580 Understanding mitochondrial function in podocyte signaling to dissect podocyte damage in idiopathic nephrotic syndrome 18 biomedica Digestive, Kidney and Urological Systems € 212.600,00 1617 GR‐2009‐1606099 DESIGN AND TEST OF A SPECIFIC CUSTOM ARRAY‐CGH FOR GENOME WIDE COPY NUMBER VARIATIONS (CNVs) ANALYSIS IN HYPERTROPHIC CARDIOMYOPATHY 18 biomedica Genes, Genomes and Genetics € 410.000,00 1618 RF‐2009‐1532956 Mechanisms and early biomarkers of cardiovascular complications and graft failure in liver transplant recipients 18 biomedica Cardiovascular and Respiratory Sciences € 549.500,00 1619 GR‐2009‐1578239 Testing the effectiveness of an intensive and comprehensive drug abuse preventive program through wastewater analysis, a novel approach to estimate drug consumption in a whole community. 18 clinico assistenziale Risk, Prevention and Health Behavior € 590.000,00 1620 GR‐2009‐1607747 An in vivo model to study molecular determinants in T‐ALL. 18 biomedica Oncology 1 ‐ Basic Translational € 351.100,00 1621 GR‐2009‐1608421 Brain metabolism and cognitive training in mild Alzheimer's Disease: exploring the neurobiological substrate of a novel cognitive intervention program 18 clinico assistenziale Brain Disorders and Clinical Neuroscience € 157.500,00 1622 RF‐2009‐1531259 Information Communication Technology resources in a model of care based on the integration between hospital and local health and social services 18 clinico assistenziale Healthcare Delivery and Methodologies € 400.000,00 1623 GR‐2009‐1576270 Mitochondrial Citrate Carrier: a new target for chemotherapeutics in cancer therapy 18 biomedica Oncology 1 ‐ Basic Translational € 300.000,00 1624 RF‐2009‐1538750 Definition of a cluster of biomarkers representative of healthy ocular surface and predictive of a pathological ocular surface manifestations: a simply method to classify inflammation. 18 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 € 166.750,00 Pagina 142 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1625 GR‐2009‐1573725 Tumor‐associated macrophages and thyroid hormone system in the pathophysiology of tumors 18 biomedica Oncology 1 ‐ Basic Translational € 406.080,00 1626 RF‐2009‐1530071 Synergistic antibiotic combinations for multidrug resistant nonfermentative gram‐ negative bacilli (Ps. aeruginosa, A.baumannii) causing severe nosocomial infections 18 clinico assistenziale Infectious Diseases and Microbiology € 400.000,00 1627 GR‐2009‐1576038 Amplitude‐integrated EEG (aEEG) and General Movements (GMs) as early indicators of neurodevelopmental outcome in preterm 18 clinico assistenziale Brain Disorders and Clinical Neuroscience € 100.000,00 1628 GR‐2009‐1550277 The expression and cellular localization of BCRP are affected by EGFR pathway in NSCLC: role of erlotinib and analysis of microRNA in the search of novel pharmacogenomics biomarkers of drug resistance 18 biomedica Oncology 1 ‐ Basic Translational € 320.000,00 1629 GR‐2009‐1608411 Vectors as indicators of infectious diseases in wildlife, livestock and humans: early surveillance by metagenomics for emerging animal infectious diseases and zoonoses. 18 biomedica Infectious Diseases and Microbiology € 367.500,00 1630 GR‐2009‐1574507 Search for novel disease genes by whole exome sequencing in patients affected by neurocristopathies and without mutations in known predisposing genes. 18 biomedica Genes, Genomes and Genetics € 415.800,00 1631 GR‐2009‐1530528 Arrhythmogenicity of Diesel Exhaust Nanoparticles in Healthy and Failing Hearts: Focus on Mechanisms 18 biomedica Cardiovascular and Respiratory Sciences € 509.112,00 1632 GR‐2009‐1607345 New chemical entities targeting human gamma delta T cells to improve tuberculosis therapy: from basic science to clinical approaches 18 biomedica Immunology € 600.000,00 1633 GR‐2009‐1569918 From new genes to new therapeutic strategies in Frontotemporal Lobar Degeneration and Alzheimer Disease 18 clinico assistenziale Brain Disorders and Clinical Neuroscience € 500.000,00 1634 RF‐2009‐1549381 Effect of parathyroidectomy and Vitamin D3 supplementation on vertebral fractures and other non classical features (quality of life, neuropsychological aspects, lipids and glucose metabolism, indexes of cardiovascular damages) of primary hyperparathyroidi 18 clinico assistenziale Oncology 2 ‐ Translational Clinical € 447.000,00 1635 RF‐2009‐1529967 PREDICTION AND PREVENTION OF FALLS IN SUBJECTS SUFFERING FROM NEUROLOGICAL DISEASES 18 clinico assistenziale Risk, Prevention and Health Behavior € 178.000,00 Pagina 143 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1636 GR‐2009‐1574027 Acid sphingomyelinase in host and tumour interaction: pathways and novel therapeutic targets 18 biomedica Oncology 1 ‐ Basic Translational € 406.080,00 1637 RF‐2009‐1510917 microRNAS AS POTENTIAL PROGNOSTIC AND THERAPEUTIC TOOLS IN MULTIPLE OSTEOCHONDROMAS DISEASE 18 biomedica Musculoskeletal, Oral and Skin Sciences € 542.000,00 1638 RF‐2009‐1550072 Antineoplastic activity of PPARalpha agonists in aggressive follicular and medullary thyroid cancers 18 biomedica Oncology 2 ‐ Translational Clinical € 495.000,00 1639 RF‐2009‐1549850 Study of gene mutations associated with phenotypic drug resistance in multidrug‐ resistant (MDR) and extensively drug ‐resistant (XDR) clinical strains of Mycobacterium tuberculosis 18 biomedica Infectious Diseases and Microbiology € 310.000,00 1640 RF‐2009‐1550808 Pain in orthopedic post‐surgical rehabilitation: occurrence, influence and basis for development and testing of a reasoned pain‐free therapeutic algorithm. 18 clinico assistenziale Healthcare Delivery and Methodologies € 289.000,00 1641 RF‐2009‐1549995 Analysis of Xenotropic Murine Leukemia Virus‐Related Virus and Human Papillomavirus infection in Italian prostate cancer patients related with RNASEL germline variants 18 biomedica Oncology 1 ‐ Basic Translational € 580.000,00 1642 RF‐2009‐1504427 ELF INDUCED MATURATION AND DIFFERENTIATION OF HUMAN CARDIAC STEM CELLS AND THEIR IMPLANTATION IN NUDE MICE: A PRECLINICAL STUDY FOR TREATING HEART ATTACKS 18 biomedica Cell Biology € 600.000,00 1643 RF‐2009‐1475645 CRYOpreservation and in vitro maturation of human oocytes by using new antioxidant formulations against ROS production (acronym: CRYOROS) 18 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 600.000,00 1644 RF‐2009‐1501341 New therapeutical strategies in head and neck squamous cell carcinoma based on the use of histone deacetylase inhibitors 18 biomedica Oncology 1 ‐ Basic Translational 1645 GR‐2009‐1474824 The epileptogenic malformed brain: pathogenic mechanisms of epilepsy and new therapeutic strategies 18 biomedica Brain Disorders and Clinical Neuroscience € 509.300,00 1646 RF‐2009‐1475820 Study on the interaction among activated fibroblasts, liver cells and ductular epithelium in cirrhosis and hepatic neoplasia. 18 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 € 361.340,00 Pagina 144 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1647 RF‐2009‐1473908 Development of a p190 derived vaccine as immune target therapy for the control of minimal residual disease in Ph+ acute lymphoblastic leukemia patients. 18 clinico assistenziale Oncology 2 ‐ Translational Clinical € 200.000,00 1648 RF‐2009‐1491252 Altered choline metabolism in ovarian cancer. Integration and interpretation of multilevel data for the validation of the significance of choline‐kinase activity and expression in prognosis and/or therapeutic guidance 18 biomedica Oncology 2 ‐ Translational Clinical € 165.000,00 1649 RF‐2009‐1472161 Cardiovascular Immunology Ontology: Reasoning to identify novel candidate genes for cardiovascular diseases 18 biomedica Bioengineering Sciences and Technologies € 278.000,00 1650 RF‐2009‐1505343 Congenital Anomalies of the Urinary Tract: Validation of Functional MR urography (MRU) as unique diagnostic step in children and development of new sequences (DWI, DTI and BOLD imaging) for the assessment of renal dysplasia. 18 biomedica Bioengineering Sciences and Technologies € 103.462,00 1651 RF‐2009‐1474901 Effects of PLP1 gene overexpression 18 biomedica Genes, Genomes and Genetics € 180.500,00 1652 RF‐2009‐1471858 Survivors of Suicide ‐ Italian Trial (SoS IT) 18 clinico assistenziale Biobehavioral and Behavioral Processes € 166.152,00 1653 RF‐2009‐1497628 Role of Bv8/prokineticin 2 and its receptors PKR1 and PKR2 in psoriasis 18 biomedica Musculoskeletal, Oral and Skin Sciences € 480.000,00 1654 RF‐2009‐1473319 NOVEL OUTCOME MEASURES AND NATURAL HISTORY IN CHARCOT‐ MARIE‐TOOTH DISEASE 18 clinico assistenziale Brain Disorders and Clinical Neuroscience € 387.500,00 1655 RF‐2009‐1499212 A multidisciplinary approach to identify molecular determinants of Triple Negative Breast Cancer 18 biomedica Oncology 2 ‐ Translational Clinical € 212.500,00 1656 GR‐2009‐1475869 PERFUSION IMAGING STUDIES OF PANCREATIC DUCTAL ADENOCARCINOMA 18 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 265.000,00 1657 RF‐2009‐1472628 Isolation of new molecules for the cure of retinal dystrophies 18 biomedica Cell Biology € 400.000,00 1658 RF‐2009‐1475769 Mineralocorticoid Receptor and human adipocyte: regulation of adipose differentiation, expansion and pro‐inflammatory capacity in visceral epicardial versus subcutaneous adipose depots 18 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 436.700,00 Pagina 145 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1659 RF‐2009‐1493811 Identification and characterization of glioblastoma cancer stem cells in a marker independent manner. 18 biomedica Oncology 1 ‐ Basic Translational € 380.000,00 1660 RF‐2009‐1492699 CLINICAL AND NEUROIMAGING PREDICTORS OF COGNITIVE IMPAIRMENT AFTER STROKE 18 clinico assistenziale Brain Disorders and Clinical Neuroscience € 160.000,00 1661 RF‐2009‐1474487 Idiopathic pulmonary fibrosis: evaluation of biological mechanisms and identification of therapeutic targets in patients and animal models 18 biomedica Cardiovascular and Respiratory Sciences € 593.000,00 1662 RF‐2009‐1474538 Unveiling neural, genetic and cognitive endophenotypes in a new model for Anorexia Nervosa: towards an individually tailored treatment. 18 clinico assistenziale Brain Disorders and Clinical Neuroscience € 599.984,00 1663 RF‐2009‐1504160 Identification of new markers of early renal dysfunction in type 2 diabetes 18 biomedica Risk, Prevention and Health Behavior € 252.000,00 1664 RF‐2009‐1475239 Genome‐based in silico identification and functional validation of novel Mycobacterium tuberculosis antigens that activate polyfunctional CD8 T cell responses in human tuberculosis 18 biomedica Immunology € 272.500,00 1665 GR‐2009‐1499228 POLYMORPHISMS of INNATE IMMUNITY GENES in HEPATOCARCINOMA 18 biomedica Genes, Genomes and Genetics € 257.000,00 1666 RF‐2009‐1550529 Molecular studies of glucosamine‐derivatives aimed to find new drugs with chondroprotective activity. 18,17 biomedica Musculoskeletal, Oral and Skin Sciences € 270.600,00 1667 GR‐2009‐1568880 Brain multi‐parametric magnetic resonance study of patients with vegetative and minimally conscious state 18,17 clinico assistenziale Brain Disorders and Clinical Neuroscience € 388.000,00 1668 GR‐2009‐1600720 How many cancer deaths were avoidable in Italy during 2000‐2007? 18,25 clinico assistenziale Healthcare Delivery and Methodologies € 344.300,00 1669 RF‐2009‐1536270 AZIB: Antitumor activity of Zoledronate in metastatic breast cancer patients: a phase II randomized study 18,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 500.000,00 1670 RF‐2009‐1510947 Role of metabotropic glutamate receptors and calcium in spinocerebellar ataxia 1 (SCA1) 18,25 biomedica Molecular, Cellular, and Developmental Neuroscience € 300.000,00 Pagina 146 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1671 RF‐2009‐1532728 Fatigue relief in Multiple Sclerosis by transcranial Direct Current neuro‐ Stimulation (tDCS). [FaMuSNeT] 18,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 449.000,00 1672 RF‐2009‐1535999 The Surgical Management of Primary Tumors of the Spine 18,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 150.000,00 1673 GR‐2009‐1521663 New approaches with nanoparticles in ex vivo human model of colon rectum cancer (CRC) for imaging and therapeutic applications. 18,25 biomedica Bioengineering Sciences and Technologies € 598.600,00 1674 GR‐2009‐1603037 SNOW‐ON‐HEART PROJECT: Magnetic resonance imaging for diagnosis of subclinical cardiotoxicity of cocaine abuse 18,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 289.250,00 1675 RF‐2009‐1526376 MULTI‐STRUCTURED DATA ANALYSIS FOR PATIENT‐SPECIFIC MODELLING OF HUMAN LIGAMENTS 18,25 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 590.000,00 1676 GR‐2009‐1604426 From ciliary protein networks to epigenetic mechanisms: developing novel in vitro strategies to study primary cilia‐related neural defects. 18,25 biomedica Molecular, Cellular, and Developmental Neuroscience € 316.800,00 1677 RF‐2009‐1549696 alpha7‐nicotinic receptor: a common target for lung cancer and Alzheimer' s disease treatment? 18,25 biomedica Oncology 2 ‐ Translational Clinical € 599.000,00 1678 RF‐2009‐1475814 Novel techniques for administration and tracking of human Mesenchymal Stem Cells in an experimental model of Parkinson's Disease: biological and therapeutic clues leading to clinical application 18,25 biomedica Brain Disorders and Clinical Neuroscience € 504.000,00 1679 RF‐2009‐1511903 Multicenter study on the mechanisms related to vessel atherosclerosis in systemic rheumatic diseases as a model of accelerated atherosclerotic damage. 18,3 biomedica Vascular and Hematology 1680 RF‐2009‐1499091 Ecological approach to the study of interspecies transmission of influenza A viruses 18,3 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 1681 RF‐2009‐1549634 A translational medicine research collaboration to fight pre‐eclampsia: from molecular pathogenesis to biomarkers of the disease and novel treatments 18,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 522.000,00 € 151.111,00 Pagina 147 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1682 GR‐2009‐1606669 Identification of microRNAs as potential targets for innovative anti‐cancer therapy 18,34 biomedica Oncology 1 ‐ Basic Translational € 490.000,00 1683 GR‐2009‐1607198 Mapping of human DNA replication origins and study of their regulation in normal and cancer cells 18,34 biomedica Oncology 1 ‐ Basic Translational € 349.300,00 1684 RF‐2009‐1529943 Functional Imaging and Biomarkers as predictors of outcome in Head and Neck cancer patients after surgery or chemo/radiotherapy 18,34 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 595.925,00 1685 GR‐2009‐1578770 Targeted magnetic iron oxide nanoparticles as contrast agents of magnetic resonance imaging of amyloid plaques in Alzheimers disease 18,34 biomedica Bioengineering Sciences and Technologies € 396.000,00 1686 GR‐2009‐1607262 Involvement of kinin‐kallikrein system in hypertension associated with IgA nephropathy: effects on renal aquaporins 18,34 biomedica Digestive, Kidney and Urological Systems € 312.000,00 1687 RF‐2009‐1473872 APPROACHES TO IMPROVE OUTCOMES OF PANCREATIC ISLETS TRANSPLANTATION IN TYPE 1 DIABETES. IDENTIFICATION OF MECHANISMS AND PREVENTION OF INFLAMMATION AS A CAUSE OF REDUCED SURVIVAL OF TRANSPLANTED ISLETS 18,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 410.000,00 1688 GR‐2009‐1607728 Characterisation of MxA and the immune infiltrates status in human renal cell carcinoma: possible utilization as prognostic markers. 18,5 clinico assistenziale Oncology 1 ‐ Basic Translational € 243.000,00 1689 RF‐2009‐1544553 Pharmacological targeting of type‐3 metabotropic glutamate receptors on cancer stem cells: an innovative anti‐cancer therapeutic strategy 18,5 biomedica Oncology 1 ‐ Basic Translational € 192.000,00 1690 GR‐2009‐1580308 GENISTEIN AGLYCONE AND METABOLIC SYNDROME IN POSTMENOPAUSAL WOMEN: MECHANISMS OF ACTION AN IN VITRO MODEL AND EVALUATION OF EFFICACY ON SOME PREDICTORS OF CARDIOVASCULAR RISK IN A DOUBLE‐BLIND RANDOMIZED CONTROLLED TRIAL 18,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 330.000,00 1691 GR‐2009‐1601098 CORTICAL MICROMALFORMATIONS, BIOCHEMICAL ABNORMALITIES, AND NEURAL NETWORKS IN SPECIFIC LANGUAGE DISORDER AND DEVELOPMENTAL COORDINATIONS DISORDER: A 3‐TESLA MORPHOLOGICAL, SPECTROSCOPY, AND FUNCTIONAL STUDY 18,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 203,80 Pagina 148 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1692 RF‐2009‐1545298 BIOMECOLECULAR PROFILING OF NORMAL AND CANCER EPITHELIAL STEM CELLS OF THE HUMAN PROSTATE 18,5 biomedica Oncology 1 ‐ Basic Translational € 310.000,00 1693 RF‐2009‐1548405 PAPILLOMAVIRUS (HPV) AND TELOMERE/TELOMERASE INTERPLAY IN HEAD & NECK AND ANAL CANCERS: CORRELATION WITH PROGNOSIS AND RESPONSE TO THERAPIES 18,5 biomedica Oncology 2 ‐ Translational Clinical € 293.000,00 1694 GR‐2009‐1606152 THE BCL‐2 POST‐TRANSCRIPTIONAL OPERON AS TARGET OF MOLECULAR CANCER THERAPEUTICS 18,5 biomedica Oncology 1 ‐ Basic Translational € 246.000,00 1695 RF‐2009‐1550953 Morphologic venous anomalies in patients with multiple sclerosis: a case‐control study 18,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 150.000,00 1696 RF‐2009‐1547201 Predictors of response to neoadjuvant chemotherapy in advanced colorectal cancer with liver resectable disease: an observational study 18,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 538.362,00 1697 RF‐2009‐1543767 An Integrative Approach to Identify Functional Biomarkers in Human Astroglial brain tumours: the '‐omics' strategy 18,5 biomedica Brain Disorders and Clinical Neuroscience € 165.000,00 1698 GR‐2009‐1580023 Prostate cancer in the elderly: biological bases and development of a multi‐marker strategy for diagnosis and prognosis 18,5 biomedica Biology of Development and Aging € 520.000,00 1699 RF‐2009‐1547763 CREATING A NETWORK FOR THE PROVINCE OF PAVIA TO ROUND CARE OF PATIENTS WITH ALS 18,5 clinico assistenziale Healthcare Delivery and Methodologies € 168.000,00 1700 RF‐2009‐1526363 PATHOGENIC MECHANISMS OF POMPE DISEASE (GLYCOGENOSIS TYPE II): CLINICAL AND EXPERIMENTAL INTEGRATED APPROACH 18,5 biomedica Genes, Genomes and Genetics € 276.500,00 1701 GR‐2009‐1523293 Study of human exposure to dioxins in selected populations living in Campania by measuring the internal dose and selected blood protein biomarkers for the evaluation of dose‐response relationship 18,5 biomedica Oncology 2 ‐ Translational Clinical € 310.000,00 1702 RF‐2009‐1549511 Retargeting of citokine‐induced killer (CIK) cells with bispecific antibodies or molecularly engrafted T‐cell receptors (TCR): a preclinical study 18,5 biomedica Oncology 2 ‐ Translational Clinical € 440.000,00 Pagina 149 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1703 RF‐2009‐1528637 Antiretroviral therapy as a preventive strategy of sexual and vertical transmission of HIV. An analysis of HIV compartimentalization in the genital secretions and in maternal breast milk: viral replication, genetic diversity, viral resistance, and local p 18,5 biomedica AIDS and Related Research € 300.000,00 1704 RF‐2009‐1526998 Unrevealing prognostic and therapeutic role of Poly(ADP‐ribose)polymerase‐1 (PARP‐1) in squamous cell carcinomas of the head and neck region. 18,5 biomedica Oncology 2 ‐ Translational Clinical € 270.000,00 1705 GR‐2009‐1567173 Genetic background of glucose homeostasis. Insulin sensitivity and ß‐cell function across the spectra of fasting glucose and glucose tolerance in youth. 18,5 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 592.710,00 1706 GR‐2009‐1607376 Role of hepatitis C in atherosclerosis development 18,5 biomedica Infectious Diseases and Microbiology € 374.000,00 1707 GR‐2009‐1574449 The impact of neuroligin inactivation by in‐utero electroporation: correlations with autistic‐like behavior in rats 18,5 biomedica Brain Disorders and Clinical Neuroscience € 325.000,00 1708 GR‐2009‐1580639 Non invasive brain stimulation with transcranial magnetic and direct current stimulation (TMS/tDCS) in vegetative and minimal conscious state patients 18,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 300.000,00 1709 GR‐2009‐1608470 Functional, physical and clinical interactions of menin and parafibromin 18,5 biomedica Oncology 1 ‐ Basic Translational € 230.000,00 1710 RF‐2009‐1545322 The last contact with a health professional before suicide: What was missed? 18,5 clinico assistenziale Risk, Prevention and Health Behavior € 386.960,00 1711 GR‐2009‐1594625 Development of a new fast chemosensitivity test for human colorectal cancer 18,5 biomedica Oncology 1 ‐ Basic Translational € 441.000,00 1712 GR‐2009‐1600680 Involvement of hypothalamicpituitaryadrenal axis dysregulation in amyotrophic lateral sclerosis murine model: a possible therapy with an oligodeoxynucleotide antisense versus endogenous pro‐opiomelanocortin mRNA. 18,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 595.600,00 1713 GR‐2009‐1601007 Quality Control in the Early Secretory Pathway and its role in Folding and Storage Disorders 18,5 biomedica Cell Biology € 550.000,00 Pagina 150 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1714 RF‐2009‐1549504 Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes in OBese patients and the impact of Insulin Resistance (OBIR) 18,5 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 200.500,00 1715 GR‐2009‐1606050 Cellular, Molecular and Serological Approaches to Characterize the Immunopathogenesis and to Identify New Diagnostic and Prognostic Markers in ACS. A Window on New Therapeutic Targets. 18,5 biomedica Vascular and Hematology € 540.000,00 1716 GR‐2009‐1606089 Role of DNA Damage Response‐signaling in differentiation, cell death and degeneration of human neural stem cell 18,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 554.333,00 1717 GR‐2009‐1607456 SUMOylation of JNK3 as a new target for neuroprotection in neuropathology 18,5 biomedica Brain Disorders and Clinical Neuroscience 1718 RF‐2009‐1539158 Macrophage response to pathogens in HIV‐1 infected individuals: role of Nef protein in supporting opportunistic infections 18,5 biomedica AIDS and Related Research € 333.333,00 1719 GR‐2009‐1604953 Definition of neurometabolic biomarkers of Alzheimers disease using H magnetic resonance spectroscopy 18,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 337.150,00 1720 GR‐2009‐1580411 Early detection of psychosis in children and adolescents: An evaluation of current at‐risk criteria 18,5 clinico assistenziale Biobehavioral and Behavioral Processes € 300.000,00 1721 RF‐2009‐1491713 Linking cell function and metabolism in T regulatory cells: implications for multiple sclerosis. 18,5 biomedica Brain Disorders and Clinical Neuroscience € 300.000,00 1722 RF‐2009‐1474978 In vivo IL‐23 and IL‐27 anti‐tumor activity against pediatric acute leukemia initiating cells and blast cells 18,5 biomedica Oncology 2 ‐ Translational Clinical € 538.500,00 1723 GR‐2009‐1473896 High field MR evaluation of brain activity in low level consciousness patients 18,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 365.000,00 1724 RF‐2009‐1474160 Minocycline intensification in HIV infected patients with persistent virologic suppression during HAART: a pilot longitudinal clinical trial 18,5 clinico assistenziale AIDS and Related Research € 235.400,00 € 452.000,00 Pagina 151 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1725 RF‐2009‐1504398 Crucial factors for effectiveness of a multicomponent prevention program for Disruptive Disorders in school‐age youths: genetic structure, psychopathological traits, psychosocial factors, and timing. 18,5 clinico assistenziale Risk, Prevention and Health Behavior € 458.000,00 1726 RF‐2009‐1494033 Towards controlling paratuberculosis in cattle through marker assisted or genomic selection 18,5 biomedica Veterinary ‐ Animal Health ‐ ANHE € 599.916,00 1727 RF‐2009‐1488439 An innovative, VLP‐based biotechnological platform for the development of CTL vaccines against viral diseases and tumors 18,5 biomedica Immunology 1728 RF‐2009‐1483496 Epigenetic changes in myelodysplastic syndromes: role of methylation and demethylating drugs 18,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 400.000,00 1729 RF‐2009‐1473902 EVALUATION OF COMBINED GENE‐ AND CELL‐BASED APPROACHES USING NEURAL AND HEMATOPOIETIC STEM CELLS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS. 18,5 biomedica Brain Disorders and Clinical Neuroscience € 350.000,00 1730 RF‐2009‐1487557 PRECLINICAL VALIDATION OF ABC TRANSPORTERS AND PROTEIN KINASES IN OSTEOSARCOMA TO OVERCOME DRUG RESISTANCE AND TO IDENTIFY NEW CANDIDATE THERAPEUTIC MARKERS 18,5 biomedica Oncology 2 ‐ Translational Clinical € 330.000,00 1731 RF‐2009‐1529648 Clonorchis and Opisthorchis in fish for human consumptions and in definitive hosts as dogs, cats and humans in the Campania region, southern Italy 18,6 biomedica Infectious Diseases and Microbiology € 600.000,00 1732 RF‐2009‐1540091 Aquaculture diet based and post stroke patient: biodisponibility of polyunsaturated fatty acids in omega‐3 enriched diets catered to patients under neuro‐rehabilitation and assessment of food safety risk factors 18,67 biomedica Veterinary ‐ Food Safety ‐ FOSA € 565.000,00 1733 GR‐2009‐1575916 Epigenetic Regulation of Inositide Signaling Pathways in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) 18,67 biomedica Cell Biology € 365.000,00 1734 GR‐2009‐1584045 Study on clock genes of ruminants in health and disease 18,67 biomedica Veterinary ‐ Animal Health ‐ ANHE € 330.000,00 1735 RF‐2009‐1500854 Foxp3 and metastatic spread 18,67 biomedica Oncology 1 ‐ Basic Translational € 445.500,00 € 511.500,00 Pagina 152 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto biomedica Oncology 2 ‐ Translational Clinical € 300.000,00 18,7 clinico assistenziale AIDS and Related Research € 293.000,00 Development of network‐based molecular signature as a tool for more efficient cancer care in NSCLC 18,75 biomedica Oncology 2 ‐ Translational Clinical € 451.800,00 1739 GR‐2009‐1608360 Clinical usefulness and prognostic value of mesothelin and other bio‐markers in patients with Malignant Pleural Mesothelioma 18,75 biomedica Oncology 2 ‐ Translational Clinical € 213.400,00 1740 RF‐2009‐1548369 Haploinsufficiency of LETM1 and mitochondrial dysfunction in Wolf‐Hirschhorn syndrome: structural and functional analysis of mitochondria in lymphoblasts, fibroblasts and myoblasts of patients and rescue analysis in vitro 18,75 biomedica Genes, Genomes and Genetics € 136.000,00 1741 GR‐2009‐1595855 Multidisciplinary approach for the characterization of molecular determinants in Gastrointestinal Stromal Tumors. 18,75 biomedica Oncology 1 ‐ Basic Translational € 404.000,00 1742 RF‐2009‐1537422 New clinical procedures in dental caries prevention 18,75 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 1743 RF‐2009‐1538531 Pancreatic endocrine tumours: from gene expression evidences to potential novel prognostic factors and therapeutic targets 18,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 290.400,00 1744 RF‐2009‐1524100 Identification and characterization of biological targets for HCC therapy 18,75 biomedica Oncology 2 ‐ Translational Clinical € 480.000,00 1745 GR‐2009‐1531353 Prospective and integrative memory in dementia 18,75 biomedica Brain Disorders and Clinical Neuroscience € 550.000,00 1746 GR‐2009‐1475924 LONG‐TERM MORBIDITY OF MULTIVISCERAL RESECTION FOR RETROPERITONEAL SARCOMA. A PROSPECTIVE LONGITUDINAL STUDY OF NEUROLOGICAL IMPAIRMENT AND CHRONIC PAIN 18,75 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 374.000,00 1747 RF‐2009‐1468910 Genetic and phenotypic characterisation of Clostridium difficile of human and animal origin to investigate on the extent of a potential zoonosis 18,8 biomedica Veterinary ‐ Animal Health ‐ ANHE € 469.800,00 1736 RF‐2009‐1471183 Effects of quercetin, a naturally occurring phytochemical, in enhancing apoptosis in chronic lymphocytic leukemia (acronym: PhytoCancer) 1737 RF‐2009‐1543831 Relationship between endotoxin levels, immune activation and anti‐Tat antibodies in sera of HIV‐infected asymptomatic individuals 1738 GR‐2009‐1567798 18,67 Pagina 153 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1748 GR‐2009‐1608727 Genetic control of the adult neurogenesis and its application in post‐stroke regenerative therapies 18,84 biomedica Molecular, Cellular, and Developmental Neuroscience € 515.000,00 1749 GR‐2009‐1524416 The NGR/isoDGR motif: a molecular timer for regulating endothelial cells adhesion to fibronectin and a tool for drug development 18,84 biomedica Oncology 1 ‐ Basic Translational € 370.000,00 1750 GR‐2009‐1605078 Design and development of solid state breath analyzers for non‐invasive measurement of markers in the human breath, finalized to applications in the monitoring and control of patients with neurological disorders. 18,84 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 473.475,00 1751 RF‐2009‐1491556 Cellular therapy to rescue diabetic complications in the BioBreading rat model of type 1 diabetes 18,84 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 599.005,00 1752 RF‐2009‐1472550 INTEGRATED APPROACH TO EVALUATE BIOLOGICAL EFFECTS ON LUNG, CARDIOVASCULAR SYSTEM AND SKIN OF OCCUPATIONAL EXPOSURE TO NANOMATERIALS (NanO I‐LuCaS) 18,84 biomedica Bioengineering Sciences and Technologies € 598.000,00 1753 RF‐2009‐1504393 Swine colostrum‐embedded chitosan‐based prosthesis: Replacement time and remodelling with autologous tissue induced by bioactive molecules for hollow organs reconstructive surgery (Te.col.pro project) 18,84 biomedica Bioengineering Sciences and Technologies € 410.039,24 1754 RF‐2009‐1473224 Dissecting the role of osteopontin in mammary carcinogenesis, from primary tumor to metastasis, toward targeted therapy. 18,84 biomedica Oncology 1 ‐ Basic Translational € 380.490,00 1755 RF‐2009‐1535850 MALIGNANT MESOTHELIOMA. ROLE OF INFLAMMATION IN TUMOUR PROGRESSION UNDER HYPOXIC CONDITIONS: IDENTIFICATION OF NEW MARKERS AND THERAPEUTIC TARGETS 19 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 1756 GR‐2009‐1606575 Cancer stem cell profiling in gastric cancer patients 19 biomedica Oncology 2 ‐ Translational Clinical € 170.000,00 1757 GR‐2009‐1568940 The development of a tissue‐engineered prosthesis using decellularized blood vessels and autologous mesenchymal stem cells 19 biomedica Cardiovascular and Respiratory Sciences € 500.000,00 1758 RF‐2009‐1540065 New molecular profiles for the diagnosis of colorectal pre‐neoplastic and neoplastic lesions 19 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 Pagina 154 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1759 RF‐2009‐1531561 Innovative strategies to control HPV‐associated lesions: delivery of E7 oncoprotein by integrase‐negative lentivirus‐derived vectors and biodegradable polymers associated with chemotherapy; Evaluation of microRNAs as therapeutic agents and targets for the 19 biomedica Oncology 2 ‐ Translational Clinical € 555.000,00 1760 GR‐2009‐1604486 Development of multi‐mycotoxins screening methods for control activities of food and feed products 19 biomedica Interdisciplinary Molecular Sciences and Training € 578.600,00 1761 RF‐2009‐1527179 MODULATION OF DRUG RESISTANCE IN BRAIN TUMORS 19 biomedica Oncology 1 ‐ Basic Translational 1762 RF‐2009‐1551262 Bevacizumab in the intrahepatic arterial treatment of Hepatocellular carcinoma nor responsive to other therapies ‐ Pilot study of feasibility and safety 19 biomedica Oncology 2 ‐ Translational Clinical 1763 GR‐2009‐1577993 TERMINAL CANCER PATIENTS' NEEDS EVALUTATION AS A BRIDGE IN COMMUNICATION BETWEEN CANCER PATIENTS, CAREGIVERS AND PROFESSIONALS 19 clinico assistenziale Healthcare Delivery and Methodologies 1764 GR‐2009‐1579796 IL‐1beta secretion by monocytes from healthy donors and patients with autoinflammatory diseases. Definition of mechanisms controlling processing and secretion, search for novel therapeutic strategies 19 biomedica Immunology € 400.000,00 1765 RF‐2009‐1539803 Genetic‐epidemiological study of the role of alterations in the mismatch repair genes in sporadic and familial endometrial and colorectal cancer in the population of the Alpine region 19 clinico assistenziale Genes, Genomes and Genetics € 559.000,00 1766 RF‐2009‐1544240 Sequential Chemotherapy with GEMOX and dual isotopes Peptide Receptors Radionuclide Therapy in the treatment of advanced stage metastatic Neuro‐ Endocrine Tumours 19 clinico assistenziale Oncology 1 ‐ Basic Translational € 460.000,00 1767 GR‐2009‐1530258 Investigation on genetic resistance factors to bovine brucellosis in the apulian cattle population serologically positive 19 biomedica Genes, Genomes and Genetics € 325.000,00 1768 GR‐2009‐1536363 An epizootiological survey of bat populations in the Italian peninsula by a wide‐ range virological diagnostic protocol: implications for public health and biological conservation 19 biomedica Veterinary ‐ Animal Health ‐ ANHE € 226.000,00 € 573.100,00 € 600.000,00 € 150.000,00 Pagina 155 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1769 RF‐2009‐1524247 Innovative Tool for Unicompartimental Knee Prostheses: Clinical Guidelines 19 clinico assistenziale Healthcare Delivery and Methodologies 1770 RF‐2009‐1543682 Effects of a controlled combined aerobic and anaerobic training vs aerobic training on quality of life, risk profile and on the achievement of sustained metabolic control in cardiac patients with comorbid type II diabetes. 19 clinico assistenziale Cardiovascular and Respiratory Sciences € 316.000,00 1771 RF‐2009‐1511435 Applicability, economic analysis and further insight into the psychoneuroendocrine mechanisms of a structured clinical and educational model (Group Care). 19 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 156.000,00 1772 GR‐2009‐1607139 Observatory for the Treatment of Chronic Hepatitis C Virus Infection in Italian Children 19 clinico assistenziale Digestive, Kidney and Urological Systems € 600.000,00 1773 RF‐2009‐1530640 Identification, validation and development of analytical methods to detect shellfishes (mollusc and crustacean) traces in foods 19 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 1774 RF‐2009‐1530471 Development of a real‐time monitoring "cockpit" to improve the safety managment in a health facility 19 clinico assistenziale Healthcare Delivery and Methodologies € 281.000,00 1775 RF‐2009‐1545092 Feasibility, implementation and effectiveness of a multielement intervention for first‐episode psychotic patients treated in Italian community mental health services. A 2‐year follow‐up study 19 clinico assistenziale Biobehavioral and Behavioral Processes 1776 GR‐2009‐1576818 Use of Hiv protease inhibitors to block cervical cancer progression and recurrence in HIV uninfected women 19 biomedica Oncology 1 ‐ Basic Translational € 333.330,00 1777 GR‐2009‐1560325 Inflammation and colorectal cancer: the hypothesis of an inflammatory niche for the maintenance of a staminal phenotype 19 biomedica Oncology 1 ‐ Basic Translational € 390.000,00 1778 GR‐2009‐1608412 Epigenetic remodelling of NCX1 gene by a specific histone deacetylase (HDAC) to identify a new drug targets to prevent or reduce the neuronal damage in brain ischemia 19 biomedica Molecular, Cellular, and Developmental Neuroscience € 237.000,00 1779 RF‐2009‐1545275 Molecular and functional analysis of CCMs genes in CCM (cerebral cavernous angiomas) patients: an expression study and clinical applications. 19 biomedica Genes, Genomes and Genetics € 400.000,00 € 564.000,00 € 600.000,00 Pagina 156 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1780 RF‐2009‐1539244 Role of PI3Kgamma in oxidative stress‐induced cerebral damage following ischemia‐reperfusion 19 biomedica Brain Disorders and Clinical Neuroscience € 386.100,00 1781 GR‐2009‐1543602 Evaluating array comparative genome hybridization (aCGH) for clinical genetic testing in Autism Spectrum Disorders 19 biomedica Genes, Genomes and Genetics € 599.500,00 1782 GR‐2009‐1604108 MicroPET preclinical development of novel peptidomimetic integrin inhibitors as innovative anticancer therapeutics in metastatic malignant melanoma 19 biomedica Oncology 2 ‐ Translational Clinical € 542.000,00 1783 RF‐2009‐1547647 Validation of a novel rehabilitative tool for upper limb motor disorders based on implicit motor imagery 19 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 177.700,00 1784 GR‐2009‐1591317 Non‐coding RNA profiling to predict drug‐resistance in high‐risk neuroblastomas 19 biomedica Oncology 1 ‐ Basic Translational € 431.333,00 1785 RF‐2009‐1521816 Proteomics strategies for the detection of illicit treatments on cattle: research of functional molecular biomarkers for food safety control. 19 biomedica Veterinary ‐ Food Safety ‐ FOSA € 346.000,00 1786 GR‐2009‐1580502 Characterization and Isolation of Cancer Stem Cells (CSCs) in Hepatocellular and Cholangiocellular Carcinoma and their Adaptation to Hypoxia. 19 biomedica Oncology 1 ‐ Basic Translational € 260.000,00 1787 GR‐2009‐1605839 AN ITALIAN PROSPECTIVE STUDY ON PERSONALITY DISORDERS 19 biomedica Genes, Genomes and Genetics € 450.000,00 1788 GR‐2009‐1592288 Adverse drug reactions related to anti‐tuberculosis therapy: clinical, pharmacogenomic and pharmacokinetic observational case‐control study 19 clinico assistenziale Genes, Genomes and Genetics € 294.000,00 1789 GR‐2009‐1605784 A kidney transplant study to assess the impact of the kidney on brain injury and stroke, in spontaneously hypertensive stroke‐prone rats 19 biomedica Brain Disorders and Clinical Neuroscience € 475.200,00 1790 RF‐2009‐1547621 GENOMIC AND PROTEOMIC BIOMARKERS FOR AUTISM SPECTRUM DISORDERS 19 biomedica Brain Disorders and Clinical Neuroscience € 598.200,00 1791 RF‐2009‐1550121 UNDERSTANDING BASIC MECHANISMS OF ROBOT‐MEDIATED NEURO‐ REHABILITATION FOLLOWING STROKE: CLINICAL AND ANIMAL STUDIES 19 biomedica Brain Disorders and Clinical Neuroscience € 588.000,00 1792 GR‐2009‐1594622 Novel strategy to improve anti‐tumor immune response: use of a tumor‐ associated antigen coupled with a TLR7 agonist 19 biomedica Oncology 2 ‐ Translational Clinical € 300.000,00 Pagina 157 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1793 GR‐2009‐1594783 Identification of possible molecular targets for development of new biological approaches in the therapy of juvenile idiopathic arthritis. 19 biomedica Immunology 1794 GR‐2009‐1580294 USEFULNESS OF BRAIN PARENCHYMA SONOGRAPHY IN EARLY DIAGNOSIS OF EXTRAPIRAMIDAL SYNDROMES AND IN THE DIFFERENTIAL DIAGNOSIS BETWEEN IDIOPATHIC PARKINSON DISEASE AND ATYPICAL PARKINSONISMS 19 clinico assistenziale Brain Disorders and Clinical Neuroscience € 0,00 1795 GR‐2009‐1580318 Infliximab‐induced modulation of systemic and mucosal immunity in patients with inflammatory bowel diseases. 19 biomedica Digestive, Kidney and Urological Systems € 217.777,00 1796 RF‐2009‐1529792 Multifunctional Nanoengineered Capsules for Imaging and Early diagnostic and Therapy of Breast Cancer. 19 biomedica Bioengineering Sciences and Technologies € 585.000,00 1797 RF‐2009‐1549348 microRNA and acute myeloid leukemia 19 biomedica Oncology 1 ‐ Basic Translational € 230.000,00 1798 GR‐2009‐1606478 REliable markers of cardiac remodeling in left ventricular Assist device: focus on C Type Natriuretic peptide [REACTioN study] 19 biomedica Cardiovascular and Respiratory Sciences € 272.200,00 1799 GR‐2009‐1580235 Study of the complex interplay among chronic cerebrospinal venous insufficiency , oxidative stress and cerebral Fe overload in MS patients 19 biomedica Brain Disorders and Clinical Neuroscience € 450.000,00 1800 GR‐2009‐1531420 EFFECT OF TOOLS IMPLEMENTING ADHERENCE TO MEDITERRANEAN DIET AND PHYSICAL ACTIVITY IN GROUPS OF SUBJECTS AT DIFFERENT LEVELS OF RISK FOR CARDIOVASCULAR DISEASES: FROM PREVENTION TO GENOMIC AND METABOLOMIC 19 biomedica Risk, Prevention and Health Behavior € 181.500,00 1801 GR‐2009‐1606659 Intracoronary administration of bone marrow‐derived mononuclear cells in ischaemic heart failure: influence of patient‐related and cell‐related factors on clinical success 19 biomedica Cardiovascular and Respiratory Sciences € 450.000,00 1802 GR‐2009‐1606638 GENETIC PREDISPOSITION TO RITONAVIR‐ASSOCIATED LIPODYSTROPHY 19 biomedica AIDS and Related Research € 270.000,00 1803 RF‐2009‐1549461 Validation of Immunological Biomarkers for the Diagnosis and Cure of Diabetic Retinopathy 19 biomedica Cell Biology € 600.000,00 € 505.000,00 Pagina 158 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1804 GR‐2009‐1606823 Detection of Neovascularization in Atherosclerotic Lesions by Ultrasound Molecular Imaging. A Feasibility and Pathophysiological Study. 19 biomedica Interdisciplinary Molecular Sciences and Training € 178.570,00 1805 RF‐2009‐1544555 Development of branched peptides as novel selective theranostic molecules for personalized cancer treatment 19 biomedica Oncology 2 ‐ Translational Clinical € 533.000,00 1806 GR‐2009‐1594592 Investigation of Hepatitis E strains in wild animals population. Evaluation of zoonotic potential, implementation of new diagnostic assays, and molecular characterization. 19 biomedica Veterinary ‐ Animal Health ‐ ANHE € 401.500,00 1807 RF‐2009‐1472373 Evaluation of Influenza A virus growth and oncolytic properties in human pancreatic tumour cells and animal models 19 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 1808 RF‐2009‐1489526 Pharmacogenomics of clopidogrel in acute coronary syndromes. 19 clinico assistenziale Cardiovascular and Respiratory Sciences € 400.000,00 1809 RF‐2009‐1470782 Evaluation of innovative immunomagnetic concentration and development of multiplex Real‐Time PCR methods for detecting and monitoring pathogenic human viruses (HAV, Norovirus GGI and GGII) in vegetables and soft fruit: correlation with human cases 19 biomedica Veterinary ‐ Food Safety ‐ FOSA € 585.000,00 1810 RF‐2009‐1494015 Role of Ataxia Telangiectasia Mutated kinase in the modulation of protein stability and autophagy 19 biomedica Cell Biology € 430.000,00 1811 RF‐2009‐1487671 Widening p53 and EGFR co‐players in light of targeted treatments in head and neck squamous cell carcinoma. 19 biomedica Oncology 1 ‐ Basic Translational € 247.500,00 1812 RF‐2009‐1475085 Endogenous retroelements in prostate cancer: an investigation of their role in cancer‐associated mutation, carcinogenesis and as candidate targets in anti‐cancer therapy 19 biomedica Genes, Genomes and Genetics € 600.000,00 1813 RF‐2009‐1491304 THE STEMNESS AND EPITHELIAL‐TO‐MESENCHYMAL TRANSITION IN BREAST CANCER: IDENTIFICATION OF NEW MOLECULAR DETERMINATS 19 biomedica Oncology 1 ‐ Basic Translational € 428.000,00 1814 RF‐2009‐1475078 Robotic‐assisted locomotion training in children affected by Cerebral Palsy (CP): comparison between different rehabilitation approaches and quantitative/instrumental evaluation . 19 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 345.000,00 Pagina 159 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1815 RF‐2009‐1487446 Characterization of UL14 gene in herpesvirus isolates from Water Buffalo (Bubalus bubalis) in Campania Region: its role in viral neurovirulence and impact on vaccination strategy. 19 biomedica Veterinary ‐ Animal Health ‐ ANHE € 596.000,00 1816 RF‐2009‐1473577 Autoimmunity in rare diseases: from a network supported by an advanced IT system to diagnosis, natural history, research and care in Aicardi‐Goutières syndrome with application to other autoimmune disorders 19 clinico assistenziale Brain Disorders and Clinical Neuroscience € 360.000,00 1817 RF‐2009‐1550887 Development and clinical experimentationof a low‐cost telerehabilitation framework based on kinematic and electromyographic biofeedback techniques 19,17 clinico assistenziale Bioengineering Sciences and Technologies € 455.000,00 1818 RF‐2009‐1491759 TTV and related anellovirus: a new surrogate marker for ensuring food safety 19,17 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 1819 RF‐2009‐1475569 Discovery and validation of methylation based biomarkers for breast cancer. 19,17 biomedica Oncology 1 ‐ Basic Translational € 439.000,00 1820 RF‐2009‐1487724 Phase I protocol for the treatment of patients affected by unresectable grade II‐IV gliomas overexperessing somatostatin receptors with a combination therapy of sistemic temozolamide ad intratumoral 90Y‐DOTATOC 19,17 biomedica Oncology 2 ‐ Translational Clinical € 315.000,00 1821 RF‐2009‐1537247 Reduction of atherogenic and carcinogenic risks in milk and beef consumers by increasing the content of n‐3 polyunsaturated fatty acids (PUFA) and conjugated linoleic acid (CLA) in milk and meat by feeding ruminants' diets with supplements rich in rumen p 19,25 biomedica Veterinary ‐ Animal welfare ‐ ANWE € 250.000,00 1822 GR‐2009‐1595694 Investigational study of T cell immune synapse impairment induced by ALL and AML tumor cells and of the potential reverting activity of lenalidomide‐azacitidine combinations 19,25 biomedica Oncology 2 ‐ Translational Clinical € 285.000,00 1823 GR‐2009‐1606768 Assessment and management of craniofacial predisposing factors for sleep disordered breathing and sleep bruxism in a pediatric orthodontic population. 19,25 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 190.000,00 1824 GR‐2009‐1579837 Alkaline sphingomyelinase: A novel potential diagnostic and prognostic molecular marker for inflammatory bowel disease and colorectal cancer 19,25 biomedica Oncology 2 ‐ Translational Clinical € 291.135,00 1825 RF‐2009‐1551343 Combined active and passive ErbB2 based immunotherapy in breast cancer patients with low expression of antigen 19,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 1.000.390,00 Pagina 160 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1826 GR‐2009‐1608644 Biomarkers of adverse neuropsychological outcomes in preterm newborns: Structural/functional connectivity Magnetic Resonance Imaging (MRI) and Magnetoencephalography (MEG) 19,25 biomedica Brain Disorders and Clinical Neuroscience € 346.500,00 1827 GR‐2009‐1599851 Study of the mechanisms involved in radiation‐induced brain injury: evaluation of microenvironment changes in relation to the radiation quality 19,25 biomedica Oncology 2 ‐ Translational Clinical € 370.000,00 1828 GR‐2009‐1606864 A PROJECT IN SICILY TO RAISE DONKEY'S MILK ‐ DRINK/FOOD OF THE THIRD MILLENNIUM. IN VITRO STUDIES ON INTESTINAL AND ORAL MUCOSA CULTURES ABOUT THE TOXICITY OF DONKEY'S MILK, AND IN VIVO STUDIES ON PAEDIATRIC PATIENTS WITH ALLERGY TO COW'S MILK AND INTOLER 19,25 biomedica Veterinary ‐ Food Safety ‐ FOSA € 491.500,00 1829 RF‐2009‐1525637 TRAINING WITH SLOW BREATHING IN HEART FAILURE: A NON‐INVASIVE METHOD TO INCREASE THE CHOLINERGIC ANTI‐INFLAMMATORY PATHWAY 19,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 280.000,00 1830 RF‐2009‐1549173 Identification of targets for therapeutic intervention in lung cancer in never smokers through sequencing of the trascriptome 19,25 biomedica Oncology 1 ‐ Basic Translational € 595.000,00 1831 RF‐2009‐1499408 Enteric pathogens infection risk in cancer patients and their relatives: infections prevalence, incidence and molecular epidemiology; hospital and domestic environmental hygiene; preventive and educational programs 19,25 biomedica Population Sciences and Epidemiology € 472.000,00 1832 GR‐2009‐1498960 VALIDATION OF A BLOOD SCREENING TEST FOR EARLY DIAGNOSIS OF PRION DISEASES IN HUMANS 19,25 biomedica Brain Disorders and Clinical Neuroscience € 194.445,00 1833 RF‐2009‐1473128 Cerebellar abnormalities, neuromuscular and developmental disorders: a clinical, hystopathological and genetic study 19,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 600.000,00 1834 GR‐2009‐1599831 EFFECTS OF IMPLANTED BONE MARROW‐DERIVED MESENCHYMAL STEM CELLS ON ANAL SPHINCTERS INJURIES: PERSPECTIVES FOR TREATMENT OF ANAL INCONTINENCE 19,34 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 543.150,00 1835 RF‐2009‐1543753 Surgical Treatment of Musculoskeletal Tumours localized in the Pelvic Region: The Technological Support given by Computer‐Assisted Surgery 19,34 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 597.850,00 Pagina 161 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1836 RF‐2009‐1500812 Impact of lifestyle factors on cancer outcomes and their interactions with tumor characteristics and therapies 19,34 biomedica Population Sciences and Epidemiology € 169.400,00 1837 RF‐2009‐1470017 Verocytotoxin‐producing Escherichia coli (VTEC) O157: identification of bacterial and host factors involved in cattle colonisation and influencing the shedding of the pathogen. 19,34 biomedica Infectious Diseases and Microbiology € 480.000,00 1838 GR‐2009‐1594591 STUDY ON THE EXPRESSION OF THE hMENA PROTEIN IN PSORIASIS 19,5 biomedica Musculoskeletal, Oral and Skin Sciences € 250.000,00 1839 GR‐2009‐1607688 Harnessing reactive oxygen species to target cancer cells 19,5 biomedica Oncology 1 ‐ Basic Translational € 450.000,00 1840 GR‐2009‐1601112 New therapeutical strategy for stroke: rational design and synthesis of peptidomimetic compounds based on molecular determinants that activate sodium calcium exchanger in the central nervous system 19,5 biomedica Brain Disorders and Clinical Neuroscience € 387.000,00 1841 RF‐2009‐1538332 Genetic epidemiology of Multiple Endocrine Neoplasia Type 1 syndrome in Italy: MEN1 3'UTR sequencing test and haplotype analysis at 11q13 in a large Italian series of sporadic and familial MEN1 cases 19,5 biomedica Genes, Genomes and Genetics € 480.000,00 1842 RF‐2009‐1525941 Use of natural terpenoid‐based products for Legionella control in hospital hot‐ water distribution systems. Toxicological assessment of the active principle and its antimicrobial efficacy in comparison with two conventional disinfection treatments (chlorin 19,5 clinico assistenziale Infectious Diseases and Microbiology € 522.000,00 1843 RF‐2009‐1536497 Advanced Glycated End‐products (AGE) and deglycating enzymes in AGEing 19,5 biomedica Biology of Development and Aging € 470.000,00 1844 RF‐2009‐1521766 The common marmoset (Callithrix jacchus) as a model for anxiety disorders: An integration of different diagnostic methodologies with transferability to the clinics 19,5 biomedica Biobehavioral and Behavioral Processes € 388.888,00 1845 RF‐2009‐1512025 PLC beta2 in breast cancer: a possible role in determining malignant cell features 19,5 biomedica Oncology 1 ‐ Basic Translational € 188.500,00 1846 GR‐2009‐1550914 Combined effects of two peroxisome proliferatoractivated receptor‐gamma (PPAR‐gamma) agonists in the early phases of diabetic retinopathy 19,5 biomedica Cell Biology € 302.000,00 Pagina 162 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1847 RF‐2009‐1510896 Evaluation of Mycobacterium bovis/Mycobacterium caprae contamination of cattle and buffalo milk in bovine tuberculosis outbreaks 19,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 350.000,00 1848 RF‐2009‐1548882 Early Quantitative Image‐Based Prediction of efficacy of antiangiogenic drug treatment, in metastatic cancer patients using Dynamic Contrast Enhanced Ultrasound 19,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 627.400,00 1849 GR‐2009‐1608315 Identification of genetic factors predisposing to non‐syndromic cleft lip with or without cleft palate (CL/P) 19,5 biomedica Genes, Genomes and Genetics € 240.600,00 1850 GR‐2009‐1607343 Semantics at rest and Autism 19,5 biomedica Brain Disorders and Clinical Neuroscience € 337.000,00 1851 GR‐2009‐1608247 Appropriateness and safety of drugs prescription in elderly: a new application of text mining 19,5 clinico assistenziale Risk, Prevention and Health Behavior € 250.000,00 1852 GR‐2009‐1608180 EXPANSION OF THE LIVING DONOR KIDNEY TRANSPLANTATION PROGRAM: HYPERIMMUNE RECIPIENTS AND AB0 INCOMPATIBLE TRANSPLANTATION 19,5 clinico assistenziale Immunology € 449.000,00 1853 GR‐2009‐1591926 Practical application for Real Time Microchip PCR: pilot study for routine monitoring of allele frequency differences of MC1R variants across population 19,5 biomedica Bioengineering Sciences and Technologies € 500.000,00 1854 RF‐2009‐1544638 Is levodopa really toxic? An electrophysiological and morphological investigation on mammalian substantia nigra dopaminergic neurons 19,5 biomedica Brain Disorders and Clinical Neuroscience € 380.000,00 1855 RF‐2009‐1550060 Markers of sensitivity to specific antitumor agents in HER2 Positive and Triple Negative Breast Cancer 19,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 442.400,00 1856 RF‐2009‐1539445 Neuroimaging study of cerebral reorganization induced by robot mediated therapy in children with hemiparesis 19,5 biomedica Brain Disorders and Clinical Neuroscience € 462.000,00 1857 GR‐2009‐1605617 The unawareness of illness and executive dysfunction in bipolar outpatients 19,5 clinico assistenziale Biobehavioral and Behavioral Processes € 126.500,00 1858 GR‐2009‐1594690 Immunity and disability in multiple sclerosis: investigating the possible correlations between circulating CD4+ and CD8+ T cell functions and measures of disability in Multiple Sclerosis, in order to identify new markers of disability. 19,5 biomedica Brain Disorders and Clinical Neuroscience € 181.000,00 Pagina 163 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1859 GR‐2009‐1607758 Stop Bleeding. A multicenter randomized controlled study with active control, aimed at analyzing the impact of two different transfusion strategies on hospital mortality, consumption of packed red cells and the development of coagulopathy in trauma patie 19,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 600.000,00 1860 RF‐2009‐1550171 Pathological and molecular characterization of screen detected and interval colorectal cancers in Italian Colorectal Cancer Screening Programmes 19,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 576.700,00 1861 GR‐2009‐1567419 Impact of Obesity on Cardiovascular Disease: Role of Adipokines, Inflammation and Oxidative Stress 19,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 347.000,00 1862 GR‐2009‐1580279 Development of Graph Theoretical Measures for the Evaluation of Brain Functional Networks from EEG signals ‐ Application to Motor Recovery through Brain‐Computer Interfaces 19,5 biomedica Emerging Technologies and Training in Neurosciences € 135.000,00 1863 GR‐2009‐1607804 Assessment of the clinical relevance of CDKN2A Unclassified Variants (UVs) in familial malignant melanoma/pancreatic cancer syndrome by functional and structural analyses 19,5 biomedica Genes, Genomes and Genetics € 172.200,00 1864 GR‐2009‐1578271 Mechanisms and Pattern of High‐Grade Glioma Diffusion. Definition of a Prevision Model and Radiobiologic Analysis for a New Irradiation Strategy 19,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 385.000,00 1865 RF‐2009‐1529077 Peptide receptor radionuclide therapy with 177Lu‐DOTATATE in resistant/refractory Diffuse Large B cell NHL 19,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 443.300,00 1866 GR‐2009‐1607358 Role of Msy‐3/Csda in developmental transitions occurring in muscle maturation, innervation and degeneration 19,5 biomedica Musculoskeletal, Oral and Skin Sciences € 455.000,00 1867 RF‐2009‐1550145 SEROLOGICAL MARKERS AND ADVERSE CARDIOVASCULAR EVENTS: CONSTITUTION OF A TISSUE AND PLASMA BANK TO INVESTIGATE THEIR ROLE IN ETHIOPATHOGENESIS AND PREVENTION OF ATHEROSCLEROTIC VULNERABLE AND UNSTABLE PLAQUE 19,5 biomedica Vascular and Hematology € 401.000,00 1868 GR‐2009‐1606376 LATE THROMBOSIS IN DRUG‐ELUTING CORONARY STENTS: NOVEL STRATEGIES TO EVALUATE STRUT NEO‐ ENDOTHELIALISATION 19,5 biomedica Cardiovascular and Respiratory Sciences € 490.000,00 1869 RF‐2009‐1546448 Influence of detection of a refractive defect in children with attention deficit hyperactivity disorder in a treatment without stimulants. 19,5 clinico assistenziale Risk, Prevention and Health Behavior € 221.777,78 Pagina 164 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1870 RF‐2009‐1530797 Thoracoscopic da Vinci Robot‐assisted extended thymectomy in myasthenia gravis 19,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 600.000,00 1871 RF‐2009‐1487559 Evaluation of metallothionein expression, oxidative stress and inflammation in blood as possible markers for progression of alcoholic liver disease 19,5 biomedica Digestive, Kidney and Urological Systems € 285.000,00 1872 RF‐2009‐1493063 CONTROL OF TUBERCULOSIS IN THE WATER BUFFALO BY GENETIC SELECTION AND VACCINE PRODUCTION 19,5 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 1873 RF‐2009‐1471919 Exploring the molecular and cellular bases of developmental disconnection in autism: probing the role of microRNAs and axonogenesis 19,5 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 1874 RF‐2009‐1472943 Strategies to reach self‐sufficiency for anti‐tetanus and anti‐hepatitis B hyperimmune plasma in Italy: impact on public health 19,5 clinico assistenziale Healthcare Delivery and Methodologies € 520.000,00 1875 RF‐2009‐1486049 EFFECTS OF UNHEALTHY LIFESTYLES ON BONE METABOLISM, HEALING CAPABILITY, IMPLANT OSTEOINTEGRATION RATE. 19,5 biomedica Musculoskeletal, Oral and Skin Sciences € 500.000,00 1876 RF‐2009‐1475743 Platelet Activation and Endothelial Dysfunction in Type 2 Diabetic Patients with Stable Coronary Artery Disease: Insight into Pathophysiological Mechanisms by Comparative Genomics and Proteomics 19,5 biomedica Vascular and Hematology € 599.200,00 1877 RF‐2009‐1491684 Novel approaches to cure type 1 diabetes: induction of tolerance toward transplanted pancreatic islets with third‐party human umbilical cord mesenchymal stem cell lines engineered to enhance their immunosuppressive potency and allow non‐invasive traceabil 19,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 405.000,00 1878 GR‐2009‐1476259 Molecular tools for the epidemiological surveillance of V. parahaemolyticus: Multi‐ locus sequence typing approach 19,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 150.150,00 1879 GR‐2009‐1607744 New perspectives in diagnosis of atherosclerosis and vascular proliferative disorders with the support of cutting edge technologies. 19,67 biomedica Cardiovascular and Respiratory Sciences € 301.500,00 1880 RF‐2009‐1548947 Anti‐idiotypic network to anti‐transglutaminase antibodies in the pathogenesis of celiac disease 19,67 biomedica Immunology € 200.000,00 Pagina 165 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1881 RF‐2009‐1468545 Role of the interaction between reelin and sex steroids in neurobehavioural alterations isomorphic to Autism Spectrum Disorders 19,67 biomedica Brain Disorders and Clinical Neuroscience € 595.555,00 1882 GR‐2009‐1608833 Genetic and epigenetic determinants in familial late‐onset degenerative dementia 19,75 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 1883 GR‐2009‐1606680 Reducing 1‐year mortality in coronary artery bypass grafting with volatile anesthetic agents. A multicentre randomized controlled study. 19,75 clinico assistenziale Cardiovascular and Respiratory Sciences € 600.000,00 1884 GR‐2009‐1576003 Genotyping approach for the discovery of possible genetic biomarkers related to diet (Zinc)‐gene interaction and frailty in old age 19,75 biomedica Genes, Genomes and Genetics € 600.000,00 1885 GR‐2009‐1583941 In vitro and in vivo study on the effects of transcranial stimulation on cerebral ischemia: from basic mechanisms to clinical application 19,75 clinico assistenziale Integrative, Functional, and Cognitive Neuroscience € 500.000,00 1886 GR‐2009‐1566802 Structural and biochemical characterization of new HIV Env/Tat molecular complexes 19,75 biomedica AIDS and Related Research € 305.000,00 1887 GR‐2009‐1595954 The stressed synapse. The synaptic action of acute behavioural stress and the protective effect of psychiatric drugs 19,75 biomedica Molecular, Cellular, and Developmental Neuroscience € 375.000,00 1888 GR‐2009‐1607243 Investigation of structural and functional correlates of cognitive fatigue in Multiple Sclerosis patients using fMRI and MRS 19,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 499.400,00 1889 RF‐2009‐1468961 Abdominal Aortic Aneurysms (AAA): a multidisciplinary fluid dynamic and metabolic investigation of rupture risk and possible rupture site 19,75 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 227.500,00 1890 RF‐2009‐1494251 ResHomING: Innovative technology of Respiratory Home MonitorING in COPD patients 19,75 clinico assistenziale Cardiovascular and Respiratory Sciences € 592.000,00 1891 RF‐2009‐1550151 INTEGRATED HOME CARE FOR NON‐SELF SUFFICIENT ELDERLY PEOPLE: EFFECTIVENESS AND COST‐EFFECTIVENESS SOLUTIONS 19,84 clinico assistenziale Healthcare Delivery and Methodologies € 364.638,00 1892 RF‐2009‐1550759 VALIDATION OF BAG3 PROTEIN AS A MARKER OF CARDIOVASCULAR DISEASE 19,84 clinico assistenziale Cardiovascular and Respiratory Sciences € 450.000,00 Pagina 166 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1893 GR‐2009‐1594619 In vivo xenograft models as a powerful tool for lung cancer pharmacogenomic profiling 19,84 biomedica Oncology 2 ‐ Translational Clinical € 105.000,00 1894 GR‐2009‐1599725 A siRNA screen to identify novel genes synthetically lethal with Chk1 as strategy for targeted cancer therapy 19,84 biomedica Oncology 1 ‐ Basic Translational € 581.000,00 1895 RF‐2009‐1548182 Seeking an appropriate treatment for the cardiovascular diseases of Emergency Department patients: are they related to medications, smart drugs or congenital abnormalities? 19,84 clinico assistenziale Risk, Prevention and Health Behavior € 207.500,00 1896 GR‐2009‐1603088 Study of association between chronic autoimmune thyroiditis and polycystic ovary syndrome 19,84 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 177.000,00 1897 RF‐2009‐1535032 Systemic and local effect of inflammation on the obese phenotype 19,84 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 350.000,00 1898 RF‐2009‐1484983 Study of the antibiotic resistance of foodborne bacteria and the relative risk for public health 19,84 biomedica Veterinary ‐ Food Safety ‐ FOSA € 541.000,00 1899 RF‐2009‐1547745 DISAGE in Italy: Disability and Ageing Survey in Italy 20 clinico assistenziale Population Sciences and Epidemiology € 592.706,00 1900 GR‐2009‐1550365 A comprehensive strategy to eradicate prion diseases from the Italian sheep and goat populations 20 biomedica Veterinary ‐ Animal Health ‐ ANHE € 533.500,00 1901 RF‐2009‐1549518 Effect of metabolic modulation of cardiac metabolism in patients with ischemic chronic heart failure and left ventricular dysfunction 20 clinico assistenziale Cardiovascular and Respiratory Sciences € 598.000,00 1902 RF‐2009‐1539490 A new preclinical model of bone metastasis from human sarcoma and carcinoma. Evaluation of new therapeutic approaches 20 biomedica Oncology 1 ‐ Basic Translational € 180.000,00 1903 RF‐2009‐1547341 Characterization of long pentraxin PTX3 as genetic biomarker of susceptibility to endothelial dysfunction diseases: atherosclerosis and preeclampsia 20 biomedica Genes, Genomes and Genetics € 450.000,00 Pagina 167 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1904 GR‐2009‐1594731 Expression defects of the RET proto‐oncogene as a novel mechanism underlying Hirschsprung disease 20 biomedica Genes, Genomes and Genetics 1905 RF‐2009‐1546096 Increased severity of repiratory viral infections in the elderly: identification of thiol levels as biomarker and therapeutic target. 20 biomedica Infectious Diseases and Microbiology € 600.000,00 1906 GR‐2009‐1595620 Molecular characterization of the Apical Membrane Antigen‐1 from Italian strains of Babesia bigemina and study of its role in the protective host immune response. 20 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 1907 GR‐2009‐1608847 Correlation between clinical‐pathological features and gene expression profile in pediatric tumors of glial origin 20 biomedica Oncology 1 ‐ Basic Translational € 285.120,00 1908 RF‐2009‐1551234 Ribonomic approach to the development of a RNA‐based therapy for the Multiple Endocrine Neoplasia type 1 syndrome 20 biomedica Oncology 1 ‐ Basic Translational € 520.000,00 1909 RF‐2009‐1530646 Leukocyte Telomere Length and telomerase gene variants: new diagnostic/prognostic markers of cardiovascular diseases? 20 biomedica Cardiovascular and Respiratory Sciences € 512.000,00 1910 RF‐2009‐1525907 FUSION BETWEEN TUMOR CELLS AND NORMAL CELLS, OR TUMOR CELLS THEMSELVES CONTRIBUTES TO TUMOR INITIATION AND PHENOTYPIC EVOLUTION DURING CANCER PROGRESSION 20 biomedica Oncology 1 ‐ Basic Translational € 203.000,00 1911 GR‐2009‐1601154 Anti‐neuropeptide autoantibodies and nutritional changes in Alzheimer's disease and vascular dementia: a novel approach to investigate disease mechanisms. 20 biomedica Brain Disorders and Clinical Neuroscience € 250.000,00 1912 RF‐2009‐1504419 GENOME‐WIDE LINKAGE ANALYSIS OF MANDIBULAR PROGNATHISM IN ITALIAN FAMILIES: A MULTICENTER TRIAL 20 clinico assistenziale Genes, Genomes and Genetics € 330.000,00 1913 GR‐2009‐1594738 Role of the COP9 signalosome in cancer progression 20 biomedica Cell Biology € 500.000,00 1914 GR‐2009‐1547787 NEW STRATEGY TO REPAIR ACUTE NEURODEGENERATIVE DISEASE by IMPLEMENTATION OF NEUROGENESIS AND GLIOGENESIS Mechanisms VIA THE PURINERGIC SYSTEM. 20 biomedica Molecular, Cellular, and Developmental Neuroscience € 470.000,00 1915 GR‐2009‐1604497 Organized cervical cancer screening programs in Italian areas covered by population cancer registries: evaluation of outcomes and identification of critical points 20 clinico assistenziale Population Sciences and Epidemiology € 170.000,00 € 491.724,00 Pagina 168 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1916 GR‐2009‐1600611 The Impact of Cortical Pathology on the Recover after a Multiple Sclerosis Relapse 20 clinico assistenziale Brain Disorders and Clinical Neuroscience 1917 GR‐2009‐1608551 MicroRNAs: potential targets for melanoma therapy . 20 biomedica Oncology 1 ‐ Basic Translational € 500.000,00 1918 GR‐2009‐1604752 SATB1 as a novel marker of metastasis and chromosomal rearrangement in thyroid carcinoma 20 biomedica Oncology 1 ‐ Basic Translational € 220.000,00 1919 GR‐2009‐1604736 ONCOGENE‐INDUCED PROMOTION OF A PRO‐TUMORAL INFLAMMATORY MICROENVIRONMENT IN PAPILLARY THYROID CARCINOMAS 20 biomedica Oncology 1 ‐ Basic Translational € 286.000,00 1920 RF‐2009‐1549454 A cross‐over study of comparison between the traditional management model and the co‐management model of surgical patients: a new skilled role of specialist in internal medicine 20 clinico assistenziale Healthcare Delivery and Methodologies € 580.000,00 1921 GR‐2009‐1596541 Heart failure after "successful" primary percutaneous coronary intervention (PCI) for Acute Myocardial Infarction (HF‐AMI) 20 biomedica Cardiovascular and Respiratory Sciences € 517.000,00 1922 GR‐2009‐1594618 Incremental value of 64‐slice computed tomography in patients with acute myocardial infarction and without significant coronary stenosis 20 clinico assistenziale Cardiovascular and Respiratory Sciences € 150.000,00 1923 RF‐2009‐1538909 Epidemiology of motor coordination disorder: screening in an unselected school population. 20 clinico assistenziale Biobehavioral and Behavioral Processes € 225.000,00 1924 RF‐2009‐1548941 TREATMENT AND COURSE OF BIPOLAR DISORDERS. PSYCHOEDUCATION, RISK FACTORS, PREVENTION OF RELAPSES AND ENDOPHENOTYPES 20 clinico assistenziale Biobehavioral and Behavioral Processes € 600.000,00 1925 GR‐2009‐1607531 Role of the MYH9 locus in kidney diseases 20 biomedica Digestive, Kidney and Urological Systems € 322.500,00 1926 GR‐2009‐1606032 The Role of the Sensorimotor Cortex in Higher Cognitive Processing: clinical and therapeutic potential applications. 20 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 461.000,00 1927 GR‐2009‐1580583 Low‐back pain in healthcare workers. Biomechanical analysis and rehabilitation program (LOBAP) 20 clinico assistenziale Healthcare Delivery and Methodologies € 138.000,00 € 82.000,00 Pagina 169 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1928 GR‐2009‐1607726 Brain‐Heart biochemical crosstalking for understanding of the neurobiological bases of depression in patients with myocardial infarction: a clue for new therapeutical strategies 20 biomedica Biobehavioral and Behavioral Processes € 479.000,00 1929 GR‐2009‐1580635 Field and laboratory studies on sand flies and transmissible viruses in Italy 20 biomedica Infectious Diseases and Microbiology € 283.800,00 1930 GR‐2009‐1605852 The role of dopamine and endocannabinoid systems interaction in the pathogenesis of Parkinson`s disease and psychiatric comorbidity 20 biomedica Biobehavioral and Behavioral Processes € 570.000,00 1931 GR‐2009‐1576262 IDENTIFICATION OF NOVEL AUTOANTIBODIES ASSOCIATED WITH IDIOPATHIC RETROPERITONEAL FIBROSIS 20 biomedica Immunology € 589.570,00 1932 GR‐2009‐1577612 "A new model for the mandibular reconstruction" 20 biomedica Musculoskeletal, Oral and Skin Sciences € 550.000,00 1933 GR‐2009‐1608031 Functional characterization of the CCDC6 gene product, a protein responsible for a new mechanism of genome instability and a novel diagnostic and prognostic marker of human neoplasias. 20 biomedica Oncology 1 ‐ Basic Translational € 385.500,00 1934 GR‐2009‐1576310 Urethral reconstruction on bio‐adsorbable scaffold promoting urothelial stem cells migration in mini‐pig model. 20 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 400.000,00 1935 GR‐2009‐1576147 Development of a new EGFR‐based therapy targeting the activated NHERF1‐EGFR‐ NHE1 axis in pancreatic ductal adenocarcinoma 20 biomedica Oncology 1 ‐ Basic Translational € 476.150,00 1936 RF‐2009‐1548652 An Italian multicentric prospective phase III randomized, placebo‐controlled blinded investigation of six weeks vs. sixteen weeks of oral valganciclovir therapy in infants with symptomatic congenital cytomegalovirus infection. 20 clinico assistenziale Infectious Diseases and Microbiology € 395.000,00 1937 GR‐2009‐1539820 CREATION OF A BIOLOGICAL BANK OF THE POPULATION‐BASED REGIONAL REGISTRY OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS: A STEP TOWARDS CLINICAL AND PATHOGENETIC STUDIES IN EMILIA ROMAGNA REGION. 20 clinico assistenziale Brain Disorders and Clinical Neuroscience € 381.000,00 1938 RF‐2009‐1511559 Use of Platelets Rich Plasma in the treatment of Achilles Tendinopathy to reduce tendon ruptures 20 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 249.000,00 Pagina 170 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1939 RF‐2009‐1548142 Cryo‐focal therapy for prostate cancer: a stage 2a‐b phase 20 clinico assistenziale Digestive, Kidney and Urological Systems € 460.000,00 1940 GR‐2009‐1576101 New anti ‐VEGF strategies in adrecocortical tumors 20 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 266.060,00 1941 RF‐2009‐1549288 Development of innovative molecular markers as tools for the rapid and accurate detection of Anisakis, etiological agents of a fish‐borne zoonosis, in fish and squids: from the epidemiology to the diagnosis in humans 20 biomedica Veterinary ‐ Food Safety ‐ FOSA € 438.740,00 1942 RF‐2009‐1539986 BIOMORPHOLOGICAL, CULTURAL AND CLINICAL STUDY ON LONG‐TERM CRYOPRESERVED MESENCHYMAL STEM CELLS FROM EQUINE ADIPOSE TISSUE 20 biomedica Biology of Development and Aging € 349.000,00 1943 GR‐2009‐1607403 HYPERBRAIN ‐ How brains interact during real‐life social situations: simultaneous multi‐subject recording of high resolution EEG and autonomic signals 20 biomedica Bioengineering Sciences and Technologies € 343.400,00 1944 GR‐2009‐1606992 Herpes simplex virus and the cross‐talk between the NF‐kB and the HIF signaling pathways: implications in hypoxia/ischemia‐associated brain injury. 20 biomedica Infectious Diseases and Microbiology € 180.000,00 1945 GR‐2009‐1544316 Effect of mesenchymal stromal cells (MSCs) on tumor angiogenesis: potential implications in the therapy of human cancer 20 biomedica Oncology 1 ‐ Basic Translational € 599.500,00 1946 GR‐2009‐1558657 High resolution quantification of MR biomarkers in deep structures of the human brain: investigation of the thalamus and basal ganglia. 20 clinico assistenziale Brain Disorders and Clinical Neuroscience € 400.000,00 1947 RF‐2009‐1536848 Multidisciplinary vs Monodisciplinary Clinic for Prostate Cancer Patients: Evaluating patients satisfaction and Multidisciplinary Team working 20 clinico assistenziale Healthcare Delivery and Methodologies € 184.800,00 1948 RF‐2009‐1511103 Characterization of colon cancer stem cells for the identification of new prognostic markers and/or targets for novel anticancer therapies 20 biomedica Oncology 1 ‐ Basic Translational € 337.000,00 1949 GR‐2009‐1574048 Involvement of the proteasome degradation pathway and molecular chaperones in sporadic and familial neurodegenerative diseases 20 biomedica Molecular, Cellular, and Developmental Neuroscience € 399.000,00 Pagina 171 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1950 GR‐2009‐1608177 Evaluation of inflammatory status in plasma of atherosclerotic patients and healthy controls 20 biomedica Vascular and Hematology 1951 GR‐2009‐1605086 Metabolic profile in urine and blood for the identification of biomarkers of bladder cancer 20 biomedica Oncology 2 ‐ Translational Clinical € 261.000,00 1952 RF‐2009‐1539772 TRIAL STUDY ‐ TRAINING IN ITALIAN AGINGS WITH HEART FAILURE 20 clinico assistenziale Risk, Prevention and Health Behavior € 580.800,00 1953 RF‐2009‐1529578 Hypoxia, inflammation and stem cells in cancer progression 20 biomedica Oncology 1 ‐ Basic Translational € 415.000,00 1954 GR‐2009‐1604927 A comparative analysis of amniotic fluid and amniotic membrane derived cells: immunophenotypic characterization, genomic stability, gene expression modulation and in vitro stem cell potential evaluation. 20 biomedica Biology of Development and Aging € 214.000,00 1955 GR‐2009‐1606657 New strategies of intervention in cancer involving the insulin receptor isoform A 20 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 450.000,00 1956 GR‐2009‐1575615 Biochemical and ultrasonographic screening of pre‐eclampsia in the first gestational trimester. 20 clinico assistenziale Healthcare Delivery and Methodologies € 151.000,00 1957 GR‐2009‐1573194 Small Molecule Inhibitors Targeting MDM4/MDM2 Complex: Delivering a Novel Therapeutic Opportunity for Cancer Disease 20 biomedica Oncology 2 ‐ Translational Clinical € 572.631,58 1958 RF‐2009‐1548579 BIOLOGICAL MARKERS PREDICTIVE FOR EFFICACY AND SAFETY OF PHARMACOTHERAPY IN BOYS WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER: VALIDATION OF FINDINGS GENERATED IN ANIMAL MODELS 20 clinico assistenziale Brain Disorders and Clinical Neuroscience € 600.000,00 1959 GR‐2009‐1584632 A novel transgenic mouse as a tool to study the role of IL‐7 in the pathogenesis of multiple sclerosis and inflammatory bowel disease. 20 biomedica Immunology € 598.000,00 1960 GR‐2009‐1604925 Proteomic Biomarkers for IgA Nephropathy: the Interstiome Strategy 20 clinico assistenziale Digestive, Kidney and Urological Systems € 140.700,00 1961 RF‐2009‐1548599 Prospective evaluation of screening for sight‐threatening diabetic retinopathy 20 clinico assistenziale Healthcare Delivery and Methodologies € 285.000,00 € 600.000,00 Pagina 172 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1962 GR‐2009‐1566900 translating biology into clinic: a molecular approach for the identification of target key factors to combat glioma diffuse growth 20 biomedica Oncology 1 ‐ Basic Translational € 190.000,00 1963 RF‐2009‐1532563 The role of hypoxia and hypoxia response in allogeneic hematopoietic stem cells transplant 20 biomedica Oncology 1 ‐ Basic Translational € 150.000,00 1964 GR‐2009‐1606665 ASSESSING THE FUNCTIONAL ROLE OF 6‐sulfo LacNAc+ DENDRITIC CELLS (slanDC) IN THE RECONSTITUTING IMMUNE SYSTEM AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) AND IN THE TUMOUR MICROENVIRONMENT 20 biomedica Immunology € 478.000,00 1965 GR‐2009‐1569625 Flavonoids and cancer risk, with focus on proanthocyanidins derived from apples: a network of case‐control studies from Mediterranean countries. 20 clinico assistenziale Population Sciences and Epidemiology € 450.000,00 1966 GR‐2009‐1605554 Frequency of peripheral CD4 + subset, expression of Killer Immunoglobulin‐Like Receptors (KIRs) and Signaling Proteins Regulating the Cytotoxic Function of CD4 T Cells in subjects with acute ischemic stroke 20 biomedica Brain Disorders and Clinical Neuroscience € 185.000,00 1967 RF‐2009‐1472761 Staphylococcal enterotoxin risk assessment in traditional raw ewe milk Pecorino cheese 20 biomedica Veterinary ‐ Food Safety ‐ FOSA € 363.500,00 1968 RF‐2009‐1472585 Development of RNAi‐mediated silencing strategies for the design of tumour‐ targeted therapies of neuroectoderma‐derived tumours 20 biomedica Oncology 2 ‐ Translational Clinical € 237.600,00 1969 RF‐2009‐1476182 Environmental, occupational, and genetic factors in the etiology of lung cancer in EAGLE, a population based case‐control study 20 clinico assistenziale Population Sciences and Epidemiology € 169.000,00 1970 RF‐2009‐1473219 Prevalence of respiratory diseases related to climate and air pollution: a survey among young‐adults in Puglia. 20 clinico assistenziale Population Sciences and Epidemiology € 400.000,00 1971 RF‐2009‐1492736 Childhood obesity prevention project on high risk young children and development of a regional Pediatric Network for childhood obesity prevention and care 20 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 198.000,00 1972 RF‐2009‐1475708 ROLE OF ADAPTIVE AND HUMORAL IMMUNITY IN CORONARY AND MYOCARDIAL VULNERABILITY 20 clinico assistenziale Vascular and Hematology € 405.000,00 Pagina 173 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1973 RF‐2009‐1473320 Oncomirs as new biomarkers and/or therapeutic target for soft tissue sarcomas 20 biomedica Oncology 1 ‐ Basic Translational € 530.000,00 1974 RF‐2009‐1499659 Effectiveness of repeated immunizations with DNA plasmids encoding HER‐2/neu in the long‐term prevention of mammary cancer in HER‐2/neu transgenic mice 20 biomedica Biology of Development and Aging € 280.000,00 1975 RF‐2009‐1471841 SENESCENCE‐ASSOCIATED microRNAs (SAmiRs) IN CELLULAR SENESCENCE, NEOPLASTIC TRANSFORMATION AND ORGANISMAL AGING 20 biomedica Biology of Development and Aging € 470.000,00 1976 RF‐2009‐1475905 Identification of telomere maintenance mechanism‐related genes and miRNAs as prognostic and therapeutic tools. 20 biomedica Oncology 1 ‐ Basic Translational € 445.500,00 1977 RF‐2009‐1493907 Inhibition of telomerase: a therapeutic strategy for disruption of glioblastoma multiforme development 20 biomedica Oncology 1 ‐ Basic Translational € 381.000,00 1978 RF‐2009‐1483508 CHARACTERIZATION OF MECHANISMS CONTROLLING GLOMERULAR SCLEROSIS. FROM THE EXPERIMENTAL MODEL TO THERAPY 20 biomedica Digestive, Kidney and Urological Systems € 418.000,00 1979 RF‐2009‐1472214 Connexin related hereditary hearing loss: Pathogenetic mechanisms and therapeutic perspectives 20 biomedica Genes, Genomes and Genetics € 591.672,00 1980 RF‐2009‐1473855 Mapping Progressive Neurodegeneration in FTLD: a Multiparametric Study combining Biological, Clinical, Neuropsychological, and Neuroimaging Assessment 20 clinico assistenziale Brain Disorders and Clinical Neuroscience € 600.000,00 1981 RF‐2009‐1470376 Development of new orthobiologic products from tissue engineering for the regenerative and reparative medicine of the osteochondral tissue 20 biomedica Musculoskeletal, Oral and Skin Sciences € 264.600,00 1982 RF‐2009‐1468400 A nationwide analysis on the effect of therapies in patients with chronic inflammatory demyelinating polyneuropathy: cost‐utility analysis of intravenous immunoglobulin and steroid. 20 clinico assistenziale Brain Disorders and Clinical Neuroscience € 150.000,00 1983 RF‐2009‐1502319 Prospective study on Bone Mineral Density and bone quality in post‐menopausal women affected with Diabetes Mellitus type 2: role of hypothalamus‐pituitary‐ adrenal (HPA) axis and glucocorticoid sensitivity. 20 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 600.000,00 1984 RF‐2009‐1469005 Gene networking of primary hypertension and related organ complications: a strategy for individual therapy 20 clinico assistenziale Cardiovascular and Respiratory Sciences € 600.000,00 Pagina 174 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1985 RF‐2009‐1475331 Salivary gland tumours: a study of immunohistochemical markers, cancer genes, and genomic imbalances for detection of diagnostic and prognostic markers 20 biomedica Oncology 1 ‐ Basic Translational € 429.946,00 1986 RF‐2009‐1475672 Bacterial virulence factors and MicroRNAs' profiling in colon cancer 20 biomedica Oncology 1 ‐ Basic Translational € 510.000,00 1987 RF‐2009‐1493810 Role of tissue microenvironment in lung cancer development 20 biomedica Oncology 1 ‐ Basic Translational € 321.200,00 1988 RF‐2009‐1492600 Children and adolescent obesity: assessment of early markers of cardiovascular and cancer risk in a cohort of school children and adolescents in the metropolitan area of Pisa (north‐west Tuscany). Set‐up of a multi‐parameter score system to recognize chil 20 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 216.500,00 1989 RF‐2009‐1475137 Hypertrophic cardiomyopathy (HCM) and its aetiopathogenesis: search for new‐ HCM causing genes and mutations and analysis of cardiac microRNA regulatory role 20 biomedica Genes, Genomes and Genetics € 420.000,00 1990 GR‐2009‐1606141 Impact of neuroinflammation on adult neurogenesis: analysis of the modulatory role of different microglial phenotypes on neural stem cell fate determination. 20,17 biomedica Molecular, Cellular, and Developmental Neuroscience € 393.800,00 1991 GR‐2009‐1601113 in vivo antitumor effects of gamma‐ and delta‐tocotrienol on HER‐2/neu‐positive breast carcinoma in young and old ages 20,17 biomedica Biology of Development and Aging € 280.000,00 1992 RF‐2009‐1476291 DOPAMINERGIC MODULATION OF CD4+ T LYMPHOCYTES: RELEVANCE FOR NEURODEGENERATION AND NEUROPROTECTION IN PARKINSONS DISEASE ‐ THE DOPAMINERGIC NEURO‐IMMUNE CONNECTION 20,17 biomedica Brain Disorders and Clinical Neuroscience € 456.300,00 1993 RF‐2009‐1503085 New molecular targets for prognostic definition and therapeutic intervention in prostate cancer patients: from bench to clinic 20,17 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 1994 GR‐2009‐1606435 Mechanisms of cortical brain damage in multiple sclerosis: a combined molecular, neuropathological and ultra‐high field imaging study 20,25 biomedica Brain Disorders and Clinical Neuroscience € 573.100,00 1995 GR‐2009‐1607207 Drug resistance in leukemia: role of small noncoding RNA (miRNAs) and the redox status of cells. 20,25 biomedica Oncology 2 ‐ Translational Clinical € 349.000,00 Pagina 175 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 1996 RF‐2009‐1528795 IDEA: Immediate versus Delayed Erlotinib After front‐line chemotherapy in advanced Non‐Small‐Cell Lung Cancer. A randomized phase 3 clinical trial. 20,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 595.000,00 1997 RF‐2009‐1539701 Exercise and molecular pathways promoting axonal growth following spinal cord injury. 20,25 biomedica Molecular, Cellular, and Developmental Neuroscience € 415.000,00 1998 GR‐2009‐1580575 Protective mechanisms during cardiopulmonary resuscitation: role of selective head cooling 20,25 biomedica Cardiovascular and Respiratory Sciences € 631.000,00 1999 GR‐2009‐1560014 Early Diagnosis of Neurodegenerative Disorders: Absolute Quantification of Metabolic Markers by 1H Magnetic Resonance Spectroscopy at 3 Tesla. 20,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 301.275,00 2000 GR‐2009‐1577490 4.Clinical and prognostic relevance of vitamin d deficiency in acute coronary syndromes 20,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 154.000,00 2001 RF‐2009‐1539785 A phase I‐II trial of suicide gene therapy with central memory donor T cells in the context of haploidentical hematopoietic stem cell transplantation for the treatment of acute leukemia in relapse 20,25 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 2002 GR‐2009‐1604634 Sleep disruption as a basis for visual hallucinations and nocturnal confusional behaviours in DLB and PDD: a 24‐hour continuous polysomnographic study before and after rivastigmine. 20,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 189.500,00 2003 GR‐2009‐1605838 THERAPEUTIC APPROACHES TO PRION DISEASES BASED ON NANOMEDICINE AND GENE THERAPY 20,25 biomedica Molecular, Cellular, and Developmental Neuroscience € 542.410,00 2004 GR‐2009‐1580489 IMMUNEMONITORING OF T CELL RESPONSES ELICITED BY LOCAL TREATMENT OF MELANOMA LESIONS THROUGH ELECTROCHEMOTHERAPY 20,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 250.000,00 2005 RF‐2009‐1473727 STUDY OF STEREO‐EEG SIGNALS BASED ON EFFECTIVE CONNECTIVITY IN PATIENTS WITH REFRACTORY EPILEPSY: A TOOL TO IDENTIFY THE EPILEPTOGENIC ZONE AND SUPPORT SURGICAL STRATEGY 20,25 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 594.000,00 2006 RF‐2009‐1471260 Molecular biomarkers for lung cancer diagnosis 20,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 549.000,00 Pagina 176 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2007 RF‐2009‐1473181 NOVEL THERAPEUTIC APPROACH TO OVERCOME BCL‐2 RELATED DRUG RESISTANCE IN CHOLANGIOCARCINOMA: A SHIFT FROM A TUMOR‐TYPE APPROACH TO A PATIENT‐BASED APPROACH 20,25 biomedica Oncology 2 ‐ Translational Clinical € 437.932,00 2008 GR‐2009‐1511997 METABOLIC AND CARDIOVASCULAR FEATURES IN PATIENTS WITH TURNER'S SYNDROME AND AUTOIMMUNE PREMATURE OVARIAN FAILURE 20,34 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 150.000,00 2009 GR‐2009‐1577868 TSC2 CELLS IN THE PATHOGENESIS OF RARE DISEASES: TUBEROUS SCLEROSIS AND LYMPHANGIOLEIOMYOMATOSIS. A CELLULAR, MOLECULAR AND PHARMACOLOGICAL STUDY. 20,34 biomedica Cell Biology € 401.000,00 2010 RF‐2009‐1545132 Endemic and epidemic clones of Escherichia coli that cause antimicrobial‐ resistant extraintestinal infections in humans: born in the community or in the farmyard? 20,34 biomedica Infectious Diseases and Microbiology € 310.000,00 2011 RF‐2009‐1471687 Environmental and occupational exposure assessment to endocrine disrupters 20,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 600.000,00 2012 RF‐2009‐1473891 Characterization of novel RGD‐based integrin targeted agents for cancer imaging and therapy 20,34 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 539.000,00 2013 RF‐2009‐1474324 Human DNA Topoisomerase I mutations that induce drug resistance: a prospective study 20,34 biomedica Oncology 1 ‐ Basic Translational € 505.000,00 2014 GR‐2009‐1604633 HIP AND KNEE REPLACEMENT IN FRAGILE INPATIENT: GROUP VERSUS INDIVIDUAL MULTIDISCIPLINARY REHABILITATION 20,5 clinico assistenziale Healthcare Delivery and Methodologies 2015 RF‐2009‐1539452 UNRESECTABLE IN‐TRANSIT METASTATIC MELANOMA: ELECTROCHEMOTHERAPY VERSUS ELECTROIMMUNOTHERAPY. LOCAL AND SYSTEMIC EFFECTS. 20,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 425.000,00 2016 RF‐2009‐1536103 The role of complementary clinical and molecular research in the understanding of nevus evolution, stabilization and involution 20,5 biomedica Oncology 1 ‐ Basic Translational € 260.000,00 € 150.100,00 Pagina 177 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2017 RF‐2009‐1538807 EFFECT OF HAART ON HIV IMMUNE DYSREGULATION: role of multispliced RNA and drug induced secretome. 20,5 biomedica AIDS and Related Research 2018 GR‐2009‐1576386 Human mesenchymal stem cells (hMSCs) as novel therapeutic tool in neurodegenerative diseases: study of the role of purinergic receptors in hMSCs transdifferentiation in vitro into neuronal lineages. 20,5 biomedica Biology of Development and Aging € 298.000,00 2019 GR‐2009‐1583763 Effect of Glucosamine and Vitamin D on Human Osteoarthritic Cartilage 20,5 biomedica Musculoskeletal, Oral and Skin Sciences € 450.000,00 2020 GR‐2009‐1606838 Evaluation of Metallothioneins auto‐antibodies directed against human Metallothioneins in the serum of diabetes type 2 and in old subjects in relation to MT1A polymorphisms 20,5 biomedica Immunology € 350.000,00 2021 GR‐2009‐1608063 Metabolomics of Bone Malignancies 20,5 biomedica Biological Chemistry and Macromolecular Biophysics € 550.000,00 2022 RF‐2009‐1549435 Vitamin D binding protein as a new biological marker of prostate cancer 20,5 biomedica Oncology 2 ‐ Translational Clinical € 590.000,00 2023 RF‐2009‐1530058 ELECTROCHEMOTHERAPY IN ANIMAL MODEL TO IMPROVE NEW CANCER TREATMENT 20,5 biomedica Oncology 2 ‐ Translational Clinical € 483.500,00 2024 GR‐2009‐1607689 Modularity for sensory motor control: a study in the first year after a brain lesion. 20,5 biomedica Biobehavioral and Behavioral Processes € 264.000,00 2025 GR‐2009‐1605579 Evaluation of pulmonary function after ex‐vivo reperfusion of lungs unelegible for transplantation: an experimental study 20,5 biomedica Cardiovascular and Respiratory Sciences € 275.000,00 2026 GR‐2009‐1605620 Diagnosis of extra vascular lung water by means of ultrasound comets analysis: development of a new methodology and apparatus. 20,5 biomedica Cardiovascular and Respiratory Sciences € 244.200,00 2027 RF‐2009‐1548851 REGULATORY T‐CELLS IN THE MILD COGNITIVE IMPAIRMENT AND THEIR PROGNOSTIC VALUE TOWARDS THE CONVERSION TO CLINICALLY DEFINED ALZHEIMERs DISEASE 20,5 biomedica Brain Disorders and Clinical Neuroscience € 124.500,00 2028 RF‐2009‐1547275 Role of immunological impairment in myeloma progression: identification of new molecular targets for anti‐neoplastic immunity. 20,5 biomedica Oncology 1 ‐ Basic Translational € 451.000,00 € 333.330,00 Pagina 178 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2029 RF‐2009‐1532552 Progressive Multifocal leukoencephalopathy and JC Virus: a combined molecular, genetic and proteomic investigation for the discovery of new prognostic biomarkers and antiviral treatments. 20,5 biomedica Brain Disorders and Clinical Neuroscience 2030 RF‐2009‐1548608 Zoonotic risks related to the handling and consumption of meat from wild ungulates mainly hunted in Italy (wild boar / Sus scrofa, roe deer / Capreolus capreolus, red deer / Cervus elaphus and chamois / Rupicapra rupicapra). 20,5 biomedica Veterinary ‐ Food Safety ‐ FOSA 2031 GR‐2009‐1575456 MARKERS OF NEURODEVELOPMENTAL IMPAIRMENT IN A MODEL OF MATERNAL IMMUNE ACTIVATION 20,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 293.057,60 2032 GR‐2009‐1605437 Long‐term oral melatonin in patients with Cystic Fibrosis: A Randomized Controlled Trial 20,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 180.000,00 2033 RF‐2009‐1536092 HGF/c‐MET, PI3K/PTEN, IGF‐1/IGF‐1R and AKT/mTOR pathways in gastric cancer. Assessments in vivo and implications for developing novel therapeutic strategies. 20,5 biomedica Oncology 2 ‐ Translational Clinical € 294.000,00 2034 GR‐2009‐1607304 Role of the scaffold molecule KSR2 in immune cells deficiency associated to obesity: studies in mice models and humans 20,5 biomedica Immunology € 500.000,00 2035 RF‐2009‐1547973 Incidence, management, comorbidity, and prognosis of patients hospitalized for Venous ThromboEmbolism in Sardinia (iVTE‐S) 20,5 clinico assistenziale Healthcare Delivery and Methodologies € 275.000,00 2036 GR‐2009‐1470203 Effects of robotic‐aided rehabilitation on the wrist joint in hemiparetic patients: a fMRI study 20,5 biomedica Musculoskeletal, Oral and Skin Sciences € 300.900,00 2037 RF‐2009‐1476209 Role of glycation/glycoxidation products in the pathogenesis of atherosclerosis: a search for new biomarkers of increased cardiovascular risk 20,5 biomedica Cardiovascular and Respiratory Sciences € 580.000,00 2038 RF‐2009‐1474387 Relevance of BACE1 expression in Alzheimer's disease: identification of new regulators of BACE1 expression by in vitro and in vivo approaches 20,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 280.000,00 2039 RF‐2009‐1505035 miR‐221/222 and miR‐145 in the biology of glioblastoma multiforme 20,5 biomedica Oncology 1 ‐ Basic Translational € 247.500,00 € 391.500,00 € 600.000,00 Pagina 179 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto biomedica Immunology € 200.000,00 20,67 clinico assistenziale Cardiovascular and Respiratory Sciences € 400.000,00 I2D2 Information Integrated DNA Database Designing a Network to hereditary cancer sharing an integrated database of molecular oncology and dissemination of information for the management of multicentric patients and their families in ASL Lecce. 20,67 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 2043 RF‐2009‐1524300 A novel strategy to implement appropriate prescribing and reduce the morbidity burden in patients with comorbid chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) or heart failure (HF): a cluster‐randomized trial of an in‐hospit 20,67 clinico assistenziale Cardiovascular and Respiratory Sciences € 536.250,00 2044 GR‐2009‐1554607 Automatic non‐invasive system to Detect and characterize VitAl meseNchymal stem Cells in a spatio‐temporal contExt (ADVANCE) 20,67 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 551.500,00 2045 RF‐2009‐1476219 Red‐Ox proteomic and cell biology studies about the E5 oncoprotein of Human Papillomavirus type 16. A potential candidate for improved molecular markers of genital infection and carcinogenesis. 20,67 biomedica Oncology 1 ‐ Basic Translational € 495.000,00 2046 RF‐2009‐1500836 Effect of metabotropic glutamate receptor subtype 7 (mGlu7) blockade on neuropathic pain symptoms, anxiety‐related behaviour and neural death 20,7 biomedica Molecular, Cellular, and Developmental Neuroscience € 195.000,00 2047 GR‐2009‐1606816 Genotyping and Expression profiling of sex‐steroid related genes associated with autistic traits and Autism Spectrum Disorders. 20,75 biomedica Biobehavioral and Behavioral Processes € 435.000,00 2048 GR‐2009‐1577611 Molecular characterization of B‐cell Chronic Lymphocytic Leukemia (B‐CLL): integrative genomic approach by using microarray technologies 20,75 biomedica Genes, Genomes and Genetics € 483.000,00 2049 RF‐2009‐1549319 Study of genetic structure of adult and paediatric patients affected by c‐KIT related disease (mastocytosis, chronic myeloprolipherative diseases and acute leukemia) using array‐CGH technology in order to detect the presence of numerical and structural ch 20,75 biomedica Genes, Genomes and Genetics € 541.428,00 2040 RF‐2009‐1483543 Factors predictive of response to anti‐Hepatitis C Virus treatment or neoplastic progression or immune protection: a study by gene expression profiles and Functional cell assays in innate immune cells. 2041 RF‐2009‐1528294 Surgical versus Transcatheter Aortic Valve Implantation for the treatment of Severe Isolated Aortic Valve Stenosis 2042 RF‐2009‐1548780 20,5 Pagina 180 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2050 GR‐2009‐1608009 Zinc oxide application in the treatment of Periprosthetic infection 20,75 biomedica Infectious Diseases and Microbiology € 452.000,00 2051 GR‐2009‐1607718 A new pharmacological approach for the treatment of andrological diseases of the testis with low blood flow and reduced fertility 20,75 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 219.000,00 2052 GR‐2009‐1608338 mRNA and microRNA expression profiles in peripheral blood as non invasive diagnostic and prognostic markers of non‐small cell lung cancer (NSCLC) 20,75 biomedica Oncology 2 ‐ Translational Clinical € 320.000,00 2053 GR‐2009‐1600361 a randomised phase II trial of second line therapy in advanced biliary tract cancer: capecitabine vs capecitabine plus mitomycin 20,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 0,00 2054 RF‐2009‐1528245 Comparison of clinical results after treatment and biological characteristics of screen detected vs non screen detected vs interval colo‐rectal carcinomas 20,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 500.000,00 2055 GR‐2009‐1607559 PULMONARY FUNCTION AND KINEMATICS IN PATIENTS WITH PECTUS EXCAVATUM: EFFECT OF SURGICAL TREATMENT 20,75 clinico assistenziale Cardiovascular and Respiratory Sciences € 169.461,00 2056 GR‐2009‐1476096 Identification of novel prognostic factors in Hodgkin's Lyphoma through the realization of a multidsciplinary platform 20,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 600.000,00 2057 RF‐2009‐1473234 Phage therapy: a new weapon for the environment, animal and public health. An application example: Shiga toxin producing Escherichia coli (STEC) zoonoses established in industrial countries 20,75 biomedica Veterinary ‐ Animal Health ‐ ANHE € 350.000,00 2058 GR‐2009‐1583797 Study of the effects of the hepatitis C virus on the biogenesis of low density lipoproteins: development of new antiviral strategies 20,84 biomedica Infectious Diseases and Microbiology € 265.400,00 2059 GR‐2009‐1567334 SINGLE NUCLEOTIDE POLYMORPHISMS OF SNAP‐25 AS BIOMARKERS FOR AUTISM SPECTRUM DISORDERS 20,84 biomedica Molecular, Cellular, and Developmental Neuroscience € 289.000,00 2060 GR‐2009‐1580149 Establishment of an interdisciplinary research unit for the study of fatigue in the elderly 20,84 biomedica Biology of Development and Aging € 599.500,00 2061 RF‐2009‐1530966 Development of innovative therapies: new molecular targets sustaining metastatic potential of Breast CSCs 20,84 biomedica Oncology 1 ‐ Basic Translational € 590.000,00 Pagina 181 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2062 RF‐2009‐1468426 Nigrostriatal damage and hepatic dysfunction in experimental Parkinson's disease: a potential link underlying self‐perpetuating neurodegeneration and a potential target for neuroprotection 20,84 biomedica Brain Disorders and Clinical Neuroscience 2063 RF‐2009‐1539326 CLINICAL MANAGEMENT OF CRYOGLOBULINAEMIA SECONDARY TO HCV INFECTION BASED ON A NEW SPECTROPHOTOMETRIC TEST 20,88 biomedica Biological Chemistry and Macromolecular Biophysics € 331.700,00 2064 RF‐2009‐1523266 Changes in structure and recruitment of muscle synergies after cortical and cerebellar lesions 21 biomedica Integrative, Functional, and Cognitive Neuroscience € 335.060,00 2065 RF‐2009‐1505450 Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies 21 biomedica Cell Biology € 313.000,00 2066 RF‐2009‐1534853 Mechanisms of stem cell‐platelet interaction in the reparative process of the ischemic damage in cardiovascular patients 21 biomedica Cell Biology € 309.100,00 2067 GR‐2009‐1606788 Analysis of cortical EEG/MEG rhythms and non‐invasive brain stimulation for the therapy of insomnia 21 biomedica Integrative, Functional, and Cognitive Neuroscience € 462.000,00 2068 GR‐2009‐1603081 A novel cardiac MRI approach to study Early Myocardial Interstitium Remodeling in Dilated Cardiomyopathy 21 clinico assistenziale Cardiovascular and Respiratory Sciences € 246.500,00 2069 GR‐2009‐1607536 The effect of hypertension on female genital vascular activity 21 biomedica Digestive, Kidney and Urological Systems 2070 GR‐2009‐1606794 Myocardial ischemia beyond atherosclerosic plaque and endothelial dysfunction: role of genetic polimorphysm for ion channels 21 clinico assistenziale Cardiovascular and Respiratory Sciences € 599.500,00 2071 GR‐2009‐1606692 Integrated therapeutic drug monitoring and pharmacogenetics strategies for the optimal management of transplanted HIV patients 21 clinico assistenziale AIDS and Related Research € 600.000,00 2072 GR‐2009‐1606096 The neuropathological and neurochemical substrates of gastrointestinal dysfunction in a rodent model of Parkinson's disease: prospects for the development of new therapeutic strategies 21 biomedica Brain Disorders and Clinical Neuroscience € 478.000,00 € 321.957,00 € 415.000,00 Pagina 182 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2073 GR‐2009‐1606802 Dissecting neuron‐like signalling in the podocyte and the osteocyte to uncover early mechanisms of mineral metabolism alterations during renal damage. 21 biomedica Digestive, Kidney and Urological Systems € 197.000,00 2074 RF‐2009‐1521615 Use of clinical care variables with social and economic impact in the treatment of frail, elderly patients suffering from heart disease 21 clinico assistenziale Cardiovascular and Respiratory Sciences € 401.500,00 2075 GR‐2009‐1606756 Clinical Decision Support Systems and Membrane Computing 21 clinico assistenziale Healthcare Delivery and Methodologies € 91.500,00 2076 RF‐2009‐1523599 A multidisciplinary approach for molecular biomarkers in Mild Cognitive Impairment: evaluation of genetic, biochemical and neuroimaging patterns. 21 biomedica Molecular, Cellular, and Developmental Neuroscience € 296.000,00 2077 GR‐2009‐1605809 ROLE OF EXERCISE TRAINING IN PREVENTION AND TREATMENT OF AGE‐ RELATED CHRONIC DEGENERATIVE DISORDERS. ANALYSIS OF THE ROLE PLAYED BY OXIDATIVE STRESS, SIRT1 EXPRESSION, AND mTOR AND eNOS SIGNALLING PATHWAYS IN HUMANS AND RATS 21 biomedica Biology of Development and Aging € 400.000,00 2078 GR‐2009‐1580551 Platinum derived chemotherapy in Malignant Mesothelioma patients: impact of ABCC2 genetic polymorphisms on plasma levels of the drugs, clinical outcome and toxicity 21 biomedica Oncology 1 ‐ Basic Translational 2079 GR‐2009‐1594779 Synergism between natural products from lichens and antibiotics against Gram‐ negative non fermenting bacteria expressing a Multi‐Drug Resistant phenotype. Effects on planktonic life and biofilm formation 21 biomedica Infectious Diseases and Microbiology € 600.000,00 2080 RF‐2009‐1547345 Novel therapeutic approaches targeting the cross‐talk between mesenchymal stem cells and tumor cells in breast cancer 21 biomedica Oncology 1 ‐ Basic Translational € 403.000,00 2081 GR‐2009‐1560076 Esmolol as cardioplegia adjuvant in high risk cardiac surgery patients. A multicentre randomized placebo‐controlled trial. 21 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering 2082 GR‐2009‐1583757 Harnessing autophagy to promote cell death of metastatic tumors 21 biomedica Oncology 1 ‐ Basic Translational € 396.000,00 2083 RF‐2009‐1550890 Nutritional and environmental determinants of bone growth and development in children 21 biomedica Population Sciences and Epidemiology € 350.000,00 € 95.000,00 € 311.000,00 Pagina 183 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2084 GR‐2009‐1592196 Development of an experimental biological protocol able to the characterisation of new buccal and transbuccal dosage forms for local and systemic pharmacological therapies. 21 biomedica Bioengineering Sciences and Technologies € 511.500,00 2085 GR‐2009‐1560028 Plasticity of body and space representations: rehabilitative programs in the field of prosthetic devices and treatment of neuropsychological and neuropsychiatric deficits 21 clinico assistenziale Integrative, Functional, and Cognitive Neuroscience € 300.000,00 2086 GR‐2009‐1567985 Role of Toll‐Like Receptors 4, 9 and MyD88 adaptor in the pathogenesis of multiple sclerosis: analysis using immunomodulatory compounds 21 biomedica Immunology € 525.000,00 2087 RF‐2009‐1548183 linking the genetic level to mechanic and dielectric properties of physiological and pathological human diseases 21 biomedica Bioengineering Sciences and Technologies € 589.100,00 2088 GR‐2009‐1591839 New strategies for the repair of epileptogenic neuronal damage 21 biomedica Brain Disorders and Clinical Neuroscience € 0,00 2089 GR‐2009‐1551422 Role of miRNAs in Alzheimers disease and Frontotemporal Lobar Degeneration: from pathogenesis to biomarker discovery 21 biomedica Genes, Genomes and Genetics € 581.000,00 2090 RF‐2009‐1548176 microRNAs' EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA AND IN AUTOLOGOUS PERI‐TUMORAL AND NORMAL TISSUES 21 clinico assistenziale Oncology 2 ‐ Translational Clinical € 300.000,00 2091 GR‐2009‐1580214 A human recombinant Manganese Superoxide Dismutase (rMnSOD) protects Mice exposed to Dioxine intoxication from Carcinogensis and Teratogenesis risk. 21 biomedica Veterinary ‐ Animal Health ‐ ANHE € 355.000,00 2092 RF‐2009‐1524764 Anti‐HCV treatment outcome in HCV/HIV co‐infected patients: the role of dendritic cells 21 biomedica Immunology € 300.000,00 2093 RF‐2009‐1530935 LEUKODYSTROPHIES OF THE ADULTS: DEVOLOPMENT OF A DIAGNOSTIC PROTOCOL AND ASSESSMENT OF PATHOGENETIC MECHANISMS 21 clinico assistenziale Brain Disorders and Clinical Neuroscience 2094 GR‐2009‐1523234 Molecular profiling of glycosaminoglycans in MO patients: evaluation of pathophisiological alterations to define biomarkers for diagnosis and patients follow‐up 21 biomedica Biological Chemistry and Macromolecular Biophysics € 421.300,00 € 405.000,00 Pagina 184 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2095 GR‐2009‐1578181 Can the nanotechnology be useful for neurodegenerative diseases such as Alzheimer disease (AD)? A preclinical study of new target drug formulation CeO2 nanoparticles‐based as a promising innovative tool for AD treatment. 21 biomedica Brain Disorders and Clinical Neuroscience € 359.750,00 2096 GR‐2009‐1530573 Identification of new histone acetylase inhibitors with potential antitumor activity 21 biomedica Oncology 2 ‐ Translational Clinical € 560.000,00 2097 RF‐2009‐1549764 Usefulness of ultra high field (7T) brain imaging in candidates for neurosurgical treatment of epileptogenic brain lesions 21 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 230.000,00 2098 GR‐2009‐1595345 Role of metabotropic glutamate receptors in monogenic autism: new targets for pharmacological therapy 21 biomedica Molecular, Cellular, and Developmental Neuroscience € 297.000,00 2099 GR‐2009‐1555591 Morpho‐Functional characterisation of human white adipose tissue 21 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 434.500,00 2100 RF‐2009‐1547101 METABOLOMIC PROFILE OF URINE AND SERA BIOMARKERS IN FANCONI ANEMIA 21 biomedica Healthcare Delivery and Methodologies € 595.000,00 2101 GR‐2009‐1577709 Implementation of an Amniotic Fluid‐Derived Mesenchymal Stromal Cells RDG‐ Polyurethanes/Hydroxyapatite Based Bioprosthesis: An In Vivo Evaluation Study. 21 biomedica Bioengineering Sciences and Technologies € 249.000,00 2102 GR‐2009‐1580049 Tissue biomarkers with diagnostic and prognostic significance in hepatocellular carcinoma. 21 biomedica Oncology 2 ‐ Translational Clinical 2103 RF‐2009‐1475241 Integrated Network Data Analysis System for OncoGenomics (INDAS‐OG) 21 biomedica Bioengineering Sciences and Technologies € 490.000,00 2104 RF‐2009‐1501919 Role of mechanotransduction signals and sirtuins in rehabilitation coupled with physical activity 21 biomedica Musculoskeletal, Oral and Skin Sciences € 450.000,00 2105 RF‐2009‐1471574 Role of Toll‐like receptor 2 in collateral vessels development after acute ischemia 21 biomedica Cardiovascular and Respiratory Sciences € 590.600,00 € 80.000,00 Pagina 185 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2106 RF‐2009‐1475592 Clinical, functional imaging, molecular and biochemical investigation of novel gene and therapeutic targets involved in Angelman syndrome 21 biomedica Brain Disorders and Clinical Neuroscience € 598.500,00 2107 RF‐2009‐1472738 Muscular disorders and muscle cell apoptosis: the role of melatonin 21 biomedica Cell Biology € 230.000,00 2108 RF‐2009‐1489510 Gastrokine 1 and Gastric Cancer: role of the protein as tumor biomarker and tumor suppessor to optimize diagnosis and therapy of gastric carcinogenesis 21 biomedica Biological Chemistry and Macromolecular Biophysics € 200.000,00 2109 GR‐2009‐1476047 Hemo‐Dialysis treatment optimization and customization by means of patient specific hydro‐electrolytic and hemodynamic modelling 21 biomedica Digestive, Kidney and Urological Systems € 523.938,00 2110 RF‐2009‐1493224 Organization models and informatic technology for the integrated management of chronic heart failure 21 clinico assistenziale Healthcare Delivery and Methodologies € 443.300,00 2111 RF‐2009‐1470920 OBSERVANT ‐ OBservational Study of Effectiveness of avR‐taVi procedures for severe Aortic steNosis Treatment 21 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 2112 GR‐2009‐1492718 A new chemico‐pharmacological approach to heart regeneration: use of "small molecules" to generate cardiac progenitor cells and to induce their differentiation into cardiac myocytes 21 biomedica Cardiovascular and Respiratory Sciences € 463.000,00 2113 RF‐2009‐1492614 The role of chronic inflammation in cognitive impairment syndromes 21 biomedica Brain Disorders and Clinical Neuroscience € 500.000,00 2114 RF‐2009‐1474854 A new therapeutic approach for treating pancreatic cancer: use of Aurora B kinase inhibitors 21 biomedica Oncology 1 ‐ Basic Translational € 467.366,00 2115 GR‐2009‐1475161 Congenital Hyperinsulinism: from the Italian epidemiology to the discover of novel related‐genes. 21 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 263.850,00 2116 RF‐2009‐1530428 Characterization of cancer stem cells and drug resistance markers for targeted therapy of uveal melanoma: synthesis of new inhibitors of ABC transporters and development of new animal models of metastatic disease. 21,17 biomedica Oncology 1 ‐ Basic Translational 2117 GR‐2009‐1607252 fMRI neuroimages voxel based processing via CUDA for brain function assessment 21,17 clinico assistenziale Bioengineering Sciences and Technologies € 541.111,00 € 399.675,00 Pagina 186 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2118 RF‐2009‐1473017 METAL ION‐INDUCED MOLECULAR DAMAGE IN PATIENTS WITH ORTHOPAEDIC IMPLANTS 21,17 clinico assistenziale Oncology 1 ‐ Basic Translational € 165.000,00 2119 GR‐2009‐1607401 Identification of prognostic markers in posttransplant lymphoproliferative disorders: genetic lesions in peripheral blood lymphocytes during infection with viruses of the herpesviridae family 21,2 biomedica Oncology 1 ‐ Basic Translational € 447.200,00 2120 GR‐2009‐1594912 Surveillance of the circulation of enteric viruses in the infantile population of Sicily following the introduction of rotavirus vaccines. 21,25 biomedica Population Sciences and Epidemiology 2121 GR‐2009‐1607694 Advanced phenotypic and functional laboratory diagnostics in clinical lipidology: toward a more correct patient cardiovascular risk characterization for a more appropriate prescription of diagnostic exams and drug prescription 21,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 583.400,00 2122 RF‐2009‐1524195 Understanding human skeletal diseases and developing novel therapeutic strategies by using Zebrafish models 21,25 biomedica Genes, Genomes and Genetics € 417.900,00 2123 RF‐2009‐1531114 Validation of the Framingham Heart Study risk score for atrial fibrillation in a community‐based prospective cohort study in Alto Adige 21,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 190.000,00 2124 GR‐2009‐1606143 In‐depth characterisation of the immune response in the population of South African individuals enrolled in the clinical study A Multicentre, Observational, Cross‐Sectional Study to Assess the Seroprevalence of Anti‐Tat Antibodies in HIV‐ Infected Patient 21,25 clinico assistenziale AIDS and Related Research € 513.700,00 2125 GR‐2009‐1605830 Longitudinal multi‐parametric structural and functional MR of the brain in degenerative diseases of the motor system. 21,25 biomedica Brain Disorders and Clinical Neuroscience 2126 GR‐2009‐1491129 Virological and viro‐immunological monitoring of polyomavirus JC in patients with multiple sclerosis treated with natalizumab. 21,25 clinico assistenziale Infectious Diseases and Microbiology € 150.000,00 2127 GR‐2009‐1471211 IDENTIFICATION OF PROTECTIVE GENETIC FACTORS IN CARRIERS OF THE E200K PRNP MUTATION 21,25 biomedica Genes, Genomes and Genetics € 579.000,00 2128 RF‐2009‐1510974 In vitro culture of human male germ cells for couples at risk for chromosomal aneuploidy or monofactorial genetic disorders 21,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 299.750,00 € 191.500,00 € 490.000,00 Pagina 187 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2129 GR‐2009‐1600231 New methodologies for non‐invasive, quantitative and Automatic MOnitoring of childbirth LABor (AMOLAB) 21,34 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 597.000,00 2130 RF‐2009‐1511620 Prospective within patient study to assess feasibility and accuracy of real time endoscopic trans urethral in vivo staging and grading of bladder cancerous lesions by mean of optical coherence tomography combined with narrowband imaging modality 21,34 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 178.000,00 2131 RF‐2009‐1474823 Translating molecular knowledge into colorectal cancer clinical management 21,34 biomedica Oncology 1 ‐ Basic Translational € 409.200,00 2132 RF‐2009‐1526520 Identification and preclinical validation of new strategies for targeted therapy against head and neck tumors 21,5 biomedica Oncology 2 ‐ Translational Clinical € 450.000,00 2133 RF‐2009‐1521662 CT SCREENING FOR LUNG CANCER WITH A RANDOMIZED STUDY AMONG DIFFERENT SMOKING CESSATION STRATEGIES 21,5 clinico assistenziale Risk, Prevention and Health Behavior € 600.000,00 2134 GR‐2009‐1591718 Validation of a prognostic score in clinically isolated syndromes and early relapsing‐remitting multiple sclerosis. 21,5 clinico assistenziale Population Sciences and Epidemiology € 300.000,00 2135 RF‐2009‐1537299 Large scale identification of disease‐causing mutations and genetic variants predisposing to heart failure in patients with hypertrophic cardiomyopathy 21,5 biomedica Cardiovascular and Respiratory Sciences € 432.933,00 2136 RF‐2009‐1546052 Role of endothelial nitric oxide synthase (eNOS) gene polymorphisms and peripheral biomarkers related to the nitric oxide pathway in the prediction of recurrent cardiovascular events in patients with CHD (CARDIO‐DIABETES study). 21,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 600.000,00 2137 RF‐2009‐1546909 Pulmonary Arterial Hypertension Secondary to Chronic Obstructive Pulmonary Desease 21,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 195.000,00 2138 GR‐2009‐1594689 Proteomic Biomarkers to Detect Chronic Obstructive Pulmonary Disease (COPD) in Smokers 21,5 biomedica Cardiovascular and Respiratory Sciences € 569.200,00 2139 RF‐2009‐1543208 The impact of maladaptive personality on the treatment of hospitalized psychiatric patients 21,5 clinico assistenziale Biobehavioral and Behavioral Processes € 180.000,00 Pagina 188 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2140 GR‐2009‐1606740 Proteogenomics of adrenal cancer and benign adrenal neoplasia: new insights in the pathogenesis of adrenal masses 21,5 biomedica Oncology 2 ‐ Translational Clinical € 410.000,00 2141 RF‐2009‐1529019 The role of autophagy in conditioning motor neuron survival 21,5 biomedica Brain Disorders and Clinical Neuroscience € 385.000,00 2142 RF‐2009‐1538788 Physical exercise in animal models of the human motor diseases Amyotrophic Lateral Sclerosis and Muscular Dystrophy of Duchenne type. Functional properties and synaptic plasticity of neocortical and hippocampal circuits. 21,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 260.000,00 2143 GR‐2009‐1606588 Role of endoglin and TGFBeta receptor complex in the pathogenesis of thoracic aortic aneurysms: a search for new predictive biomarkers 21,5 biomedica Cardiovascular and Respiratory Sciences € 556.600,00 2144 GR‐2009‐1607636 Cognitive impairment in amyotrophic lateral sclerosis: a population‐based study 21,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 238.000,00 2145 GR‐2009‐1607484 Potentially new and reemerging epidemics 21,5 biomedica Infectious Diseases and Microbiology € 530.200,00 2146 RF‐2009‐1519477 A DNAchip for surveying: Development and clinical validation of an arrayed‐ primer extension technique for the detection and molecular characterization of aetiological agents of bacterial meningitis 21,5 biomedica Infectious Diseases and Microbiology € 555.000,00 2147 RF‐2009‐1505838 Identification of new genetic markers for a more accurate assessment of the real cardiovascular risk: a rapid and cost‐saving strategy 21,5 biomedica Vascular and Hematology € 389.000,00 2148 GR‐2009‐1532588 STUDY OF ENDOTHELIUM‐DERIVED HYPERPOLARIZING FACTOR (EDHF): A NOVEL APPROACH WITH CLINICAL IMPLICATIONS 21,5 biomedica Vascular and Hematology € 211.154,00 2149 RF‐2009‐1498731 In vitro and in vivo studies of the role of EFA6A, a guanosine exchange factor for the ARF6 small GTPase, in neuronal connectivity and in mental retardation 21,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 160.000,00 2150 RF‐2009‐1492627 Control of metastatic melanoma through immune intervention 21,5 biomedica Immunology € 450.000,00 2151 RF‐2009‐1471848 Surveillance, control and prevention of infections by multidrug‐resistant organisms in non hospital settings: nursing and residential homes 21,5 clinico assistenziale Infectious Diseases and Microbiology € 300.000,00 Pagina 189 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2152 RF‐2009‐1475223 The "sweet side" of cancer: undermining the Hexokinase association with mitochondria for a generalized tumor therapy 21,5 biomedica Biological Chemistry and Macromolecular Biophysics € 518.384,00 2153 RF‐2009‐1476170 Prevalence and Etiology of StereoAnomalies (PESA) in Northern‐Italian young adults and seniors 21,5 biomedica Biobehavioral and Behavioral Processes € 171.000,00 2154 RF‐2009‐1504326 Identification of markers of muscle fibrosis and osteoporosis in Duchenne muscular dystrophy patients 21,5 biomedica Musculoskeletal, Oral and Skin Sciences € 457.600,00 2155 RF‐2009‐1530541 CLINICAL USE OF MAGNETIC RESONANCE WHOLE BODY IMAGING FOR EARLY DETECTION OF ACTIVE MULTIPLE MYELOMA BONE DISEASE 21,67 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 180.000,00 2156 GR‐2009‐1579830 High throughput drug screening for bone regeneration using zebrafish as animal model 21,67 biomedica Musculoskeletal, Oral and Skin Sciences € 170.000,00 2157 RF‐2009‐1505435 Predictive value of integrated markers of inflammation and coagulation in an accelerated model of atherosclerosis 21,67 biomedica Cardiovascular and Respiratory Sciences € 460.000,00 2158 RF‐2009‐1547486 Role of Oxidative Stress in Central Nervous System localization of Haematological Malignancies. A proteomics, flow cytometry and molecular study. 21,75 biomedica Oncology 2 ‐ Translational Clinical € 429.000,00 2159 GR‐2009‐1574746 The abused child: a project/action based on multidsciplinary approach for a prevention strategy 21,75 clinico assistenziale Risk, Prevention and Health Behavior € 261.870,00 2160 GR‐2009‐1605436 Improving the management of Medication Overuse Headache and reducing its burden Long‐term outcome with two care approaches (in‐patient vs out‐patient) supported by an innovative electronic system 21,75 clinico assistenziale Healthcare Delivery and Methodologies € 400.000,00 2161 GR‐2009‐1606826 Behavioral and electrophysiological markers of decision‐making, and probabilistic learning associated with alcohol misuse in adults and cirrhotic patients with and without minimal hepatic encephalopathy 21,75 biomedica Integrative, Functional, and Cognitive Neuroscience € 338.000,00 2162 RF‐2009‐1474104 The Bloodless Cardiac Surgery Project A prospective quality study based on a comprehensive Patient Blood Management 21,75 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 315.000,00 Pagina 190 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 21,84 biomedica Veterinary ‐ Food Safety ‐ FOSA Human bone marrow mesenchymal stem cells: a new prospective for urine incontinence cell‐ therapy 22 biomedica Cell Biology € 315.000,00 2165 GR‐2009‐1606724 Do Copy Number Variations contribute to phenotypic variability of Klinefelter syndrome? 22 biomedica Genes, Genomes and Genetics € 200.025,00 2166 GR‐2009‐1574749 Development of novel strategies for the evaluation of HIV/AIDS vaccine‐elicited immune responses and for the identification of correlates of protection/non‐ progression 22 biomedica AIDS and Related Research € 456.000,00 2167 GR‐2009‐1603044 The vascular endothelial growth factor (VEGF) pathway in neuroendocrine tumors: in vitro and in vivo expression of VEGF and its receptors, prognostic role and evaluation of the response in vitro to specific VEGF inhibitors 22 biomedica Oncology 2 ‐ Translational Clinical € 427.300,00 2168 RF‐2009‐1549418 Cardiovascular risk profiling in solid organ transplanted patients: identification of novel predictive biomarkers 22 clinico assistenziale Vascular and Hematology € 247.000,00 2169 RF‐2009‐1511583 Evaluation of the efficacy of a multitask training in patients affeceted by Multiple Sclerosis 22 clinico assistenziale Brain Disorders and Clinical Neuroscience € 130.000,00 2170 GR‐2009‐1580468 The role of insulin resistance on mitochondrial pathways on sarcopenia over aging 22 biomedica Biology of Development and Aging € 600.000,00 2171 RF‐2009‐1524184 RANK/RANKL/OPG pathway in bone metastases of patients with neuroendocrine tumors 22 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 427.300,00 2172 GR‐2009‐1601114 C‐di‐GMP as adjuvant of DNA Vaccination on HER‐2/neu‐positive Mammary Carcinoma in young and old Ages 22 biomedica Biology of Development and Aging € 290.000,00 2173 RF‐2009‐1546353 INTERACTIONS BETWEEN BIOLOGICAL NETWORKS AS A TOOL TO DEFINE THE ROLE OF MOLECULAR‐TARGETED THERAPIES IN DIGESTIVE ENDOCRINE TUMOURS 22 biomedica Oncology 1 ‐ Basic Translational € 220.700,00 2163 RF‐2009‐1486499 Bacteriocin‐like inhibitory substance (BLIS) producing bacteria for decontamination of bivalve molluscs from pathogenic vibrios and Salmonella spp.: applicability assessment and development of experimental protocols. 2164 GR‐2009‐1607626 € 250.000,00 Pagina 191 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2174 GR‐2009‐1596219 THE ROLE OF POLYCYSTINS ON ERYTHROPOIESIS. 22 biomedica Digestive, Kidney and Urological Systems € 142.800,00 2175 GR‐2009‐1583799 Identification and characterisation of potential vectors and associated multispecies pathogens of animal in cattle dedicated environments 22 biomedica Veterinary ‐ Animal Health ‐ ANHE € 520.000,00 2176 GR‐2009‐1580428 Secondary alpha‐dystroglycanophaties: towards novel molecular diagnostic protocols. 22 biomedica Musculoskeletal, Oral and Skin Sciences € 290.400,00 2177 RF‐2009‐1539266 Transcription factor gene expression analyses in circulant mesenchymal stem cells in patients with degenerative diseases. 22 biomedica Genes, Genomes and Genetics € 236.500,00 2178 RF‐2009‐1524198 Determinants of HAART efficacy over older aged HIV‐infected population: observational study 22 clinico assistenziale AIDS and Related Research 2179 RF‐2009‐1547315 AUTOLOGOUS CARDIAC CELL THERAPY WITH BONE‐MARROW‐DERIVED CD133+ CELLS IN PATIENTS WITH ADVANCED REFRACTORY CARDIOMYOPATHY: ARRHYTHMOLOGIC ASSESSMENT 22 clinico assistenziale Cardiovascular and Respiratory Sciences € 536.800,00 2180 RF‐2009‐1519476 Type I interferons and Toll‐like receptors: two players in the pathological events of idiopathic inflammatory myopathies 22 biomedica Immunology € 406.450,00 2181 GR‐2009‐1608416 From genotype to beta cell phenotype and beyond: transcriptional and post‐ transcriptional effects of disease‐associated genes in human type 2 diabetes 22 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 173.000,00 2182 GR‐2009‐1608320 ADVANCED GLYCATION ENDPRODUCTS IN DIET AND BLOOD, DEGLYCATING ENZYMES, AND CHRONIC DISEASES IN A COHORT OF OLDER PEOPLE IN SOUTHERN ITALY 22 biomedica Population Sciences and Epidemiology € 330.000,00 2183 RF‐2009‐1539471 BV8 prokineticin system in the immune‐associated pathophysiology of neuropathic pain 22 biomedica Biobehavioral and Behavioral Processes € 240.000,00 2184 GR‐2009‐1607769 Proposal for a Semantic Integration Framework for Health Technology Assessment (HTA) 22 biomedica Healthcare Delivery and Methodologies € 333.000,00 € 60.000,00 Pagina 192 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2185 GR‐2009‐1596825 DYSLEXIA AND DYSGRAPHIA: DIFFERENT EXPRESSIONS OF A COMMON LINGUISTIC IMPAIRMENT OR MERE ASSOCIATION BETWEEN UNDERLYING COGNITIVE DEFICITS? A systematic study on the comorbidity between language impairment and learning disabilities 22 biomedica Brain Disorders and Clinical Neuroscience € 296.000,00 2186 RF‐2009‐1543773 FETUS (FEtalTeleUltraSound) CAMPANIA 22 biomedica Healthcare Delivery and Methodologies € 483.000,00 2187 GR‐2009‐1606811 Analysis of circulating tumour cells in peripheral blood and in pulmonary venous blood of patients submitted to surgery for non‐small cell lung cancer 22 clinico assistenziale Oncology 2 ‐ Translational Clinical € 346.000,00 2188 RF‐2009‐1548383 Safeguarding the Health of the Immigrant Population. Analysis of Clinical and Epidemiological Aspects, Evaluation of the Health Services, Health Policies and Training Supply 22 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 2189 GR‐2009‐1592204 Role of the redox state of methionine 35 in synaptotoxicity induced by amyloid‐ beta peptide 22 biomedica Brain Disorders and Clinical Neuroscience € 350.000,00 2190 GR‐2009‐1600988 Evaluation of multi‐exposure to pesticides in a Sicilian population and biochemical correlates for in vitro induction of insulin resistance by cellular models. 22 biomedica Population Sciences and Epidemiology € 550.000,00 2191 GR‐2009‐1607122 Executive functioning in medical residents: effects of sleep debt and usefulness of napping as a countermeasure 22 clinico assistenziale Healthcare Delivery and Methodologies € 474.000,00 2192 GR‐2009‐1576592 EFFICACY AND BIOLOGICAL CORRELATES OF PSYCHOTHERAPY: THE EFFECTS OF A TIME‐LIMITED, PSYCHODYNAMIC APPROACH ON NEUROTROPHIC FACTORS IN PATIENTS WITH MAJOR DEPRESSION. 22 clinico assistenziale Brain Disorders and Clinical Neuroscience € 331.000,00 2193 RF‐2009‐1550061 Depression and coronary artery disease (CAD); the risk factors for the onset of depression in never depressed patients at their first episode of CAD and the effect of depression on the outcome of cardiopathy 22 clinico assistenziale Cardiovascular and Respiratory Sciences € 311.040,00 2194 GR‐2009‐1606675 ROLE OF CBX7 IN HUMAN CANCERS 22 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 Pagina 193 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2195 RF‐2009‐1528996 Pharmacological modulation of allergen‐induced inflammatory and dysfunctional alterations of the airways by PPAR (Peroxisome Proliferator‐Activated Receptors) ligands. 22 biomedica Cardiovascular and Respiratory Sciences € 160.000,00 2196 GR‐2009‐1608929 Molecular characterization of the interaction between Pseudomonas aeruginosa clinical strains and cystic fibrosis airways 22 biomedica Infectious Diseases and Microbiology € 466.200,00 2197 RF‐2009‐1550776 EVALUATION OF APPROPRIATENESS, EFFICACY AND SAFETY IN CARE SETTINGS OF HOSPITALS FOR INTENSITY OF CARE 22 clinico assistenziale Healthcare Delivery and Methodologies € 600.000,00 2198 GR‐2009‐1578313 EPIDEMIOLOGICAL STUDY ON DISORDERS OF CONSCIOUSNESS: ORGANIZATIONAL AND CARE MODELS IN ITALY. ESODOC in Italy 22 clinico assistenziale Healthcare Delivery and Methodologies € 296.450,00 2199 GR‐2009‐1580047 Are dually diagnosed patients more deprived than their single diagnosis counterpart? A cross sectional study in Italian Mental Health Care Trusts 22 clinico assistenziale Healthcare Delivery and Methodologies € 386.000,00 2200 GR‐2009‐1594952 Autophagy in human neuronal ceroid lipofuscinosis: a life saver or a death partner? 22 biomedica Brain Disorders and Clinical Neuroscience € 191.000,00 2201 RF‐2009‐1505771 Erythropoietin in ALS: a study of dose‐finding, safety, and biological activity 22 clinico assistenziale Brain Disorders and Clinical Neuroscience € 524.475,00 2202 RF‐2009‐1471322 Emerging risk prioritization in nursery and primary school catering: exposure evaluation, risk management and communication 22 biomedica Veterinary ‐ Food Safety ‐ FOSA 2203 GR‐2009‐1469957 Hypoglycemia mediated brain injury: new pharmacological approaches 22 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 567.330,00 2204 RF‐2009‐1475591 Intrauterine growth restriction, oxidative stress and neurodevelopmental outcomes 22 biomedica Biobehavioral and Behavioral Processes € 508.200,00 2205 RF‐2009‐1502216 A novel global approach to face Mycobacterium bovis tuberculosis in man and animals today 22 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 2206 RF‐2009‐1489723 IS HIGH ORAL DOSE L‐ARGININE SUPPLEMENTATION EFFECTIVE IN LEUKOARAIOSIS? A PRELIMINARY HOSPITAL‐BASED STUDY 22 clinico assistenziale Brain Disorders and Clinical Neuroscience € 184.500,00 € 400.000,00 Pagina 194 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2207 GR‐2009‐1486630 Antitumoral effect of 3‐O‐methylfunicone (OMF) from Penicillium pinophilum in in vitro model of melanoma and in animals. Effect of OMF combined with traditional chemiotherapy 22 biomedica Oncology 1 ‐ Basic Translational € 208.000,00 2208 RF‐2009‐1475671 A proteomic approach to search potential biomarkers useful in colon cancer diagnosis 22 biomedica Oncology 1 ‐ Basic Translational € 351.000,00 2209 GR‐2009‐1594636 Define the role of calcineurin/nuclear factor of activated T cells (NFAT) pathway activation in leukemogenesis, in particular to identify key regulators and new calcineurin substrates that could have an important role in tumor development and could be pot 22,17 biomedica Oncology 1 ‐ Basic Translational € 308.000,00 2210 GR‐2009‐1521767 PROMISES study: Multicenter project Sleep and Heart Failure 22,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 376.000,00 2211 GR‐2009‐1553651 Role of environmental contaminants and eating habits as carcinogenetic cofactors influencing the risk of developing hepatocellular carcinoma in patients with HCV‐ related liver cirrhosis 22,25 biomedica Risk, Prevention and Health Behavior € 573.100,00 2212 RF‐2009‐1546250 FACTORS ASSOCIATED WITH RECURRENCE OF UPPER RESPIRATORY TRACT INFECTION IN CHILDREN AT RISK (1‐6 YEARS OLD): A COHORT STUDY 22,25 clinico assistenziale Infectious Diseases and Microbiology € 237.700,00 2213 RF‐2009‐1529774 Nuclear Magnetic Resonance Metabolomics as innovative diagnostic approach to Alzheimer's Disease 22,25 biomedica Brain Disorders and Clinical Neuroscience € 382.400,00 2214 GR‐2009‐1473305 Effect of the C1584G polymorphism of CYP2D6 on the efficacy of galantamine in patients with Alzheimer disease. 22,25 clinico assistenziale Genes, Genomes and Genetics € 248.475,00 2215 RF‐2009‐1548206 Fertility preservation in breast cancer patients: The evaluation of two ovarian tissue freezing techniques 22,34 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 383.000,00 2216 GR‐2009‐1594744 Characterization of mesenchymal stem cells able to participate in liver regeneration and development of a reproducible clinical protocol of stem cell transplantation in patients with chronic liver diseases 22,34 biomedica Digestive, Kidney and Urological Systems € 600.000,00 2217 RF‐2009‐1532700 Metabolic syndrome and cardiovascular risk: identification of new gender associated risk factors 22,34 biomedica Cardiovascular and Respiratory Sciences € 570.000,00 Pagina 195 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2218 RF‐2009‐1545789 The role of retrograde perfusion to reduce ischemic‐reperfusion injury in double lung transplantation: a prospective randomized clinical study. 22,34 clinico assistenziale Cardiovascular and Respiratory Sciences € 150.000,00 2219 GR‐2009‐1605290 Modulation of gene expression after GM‐SCF signaling reactivation in Pulmonary Alveolar Proteinosis. 22,34 biomedica Genes, Genomes and Genetics € 249.000,00 2220 GR‐2009‐1551739 Sleep related risk factors for postpartum depression 22,5 clinico assistenziale Risk, Prevention and Health Behavior € 431.100,00 2221 RF‐2009‐1530506 Exploiting the tumor microenvironment for the identification of mechanisms of induced resistance to paclitaxel and anti‐VEGF therapy in solid tumors as rationale for combination therapy. 22,5 biomedica Oncology 1 ‐ Basic Translational € 322.220,00 2222 GR‐2009‐1607761 Phenotypic, Neurocognitive, Genetic and Surgical Characterization of Hypoplastic Left Heart Syndrome (HLHS) 22,5 biomedica Cardiovascular and Respiratory Sciences € 106.501,00 2223 GR‐2009‐1559720 Regeneration of neuronal activity via multi‐walled carbon nanotubes 22,5 biomedica Bioengineering Sciences and Technologies € 500.000,00 2224 GR‐2009‐1578007 Novel bioactive nanostructured systems for gene therapy and vaccine development 22,5 biomedica Immunology € 580.000,00 2225 GR‐2009‐1607407 The Influence of Acetabular Labrum on Hip Joint Stability: a Biomechanical Analysis 22,5 biomedica Bioengineering Sciences and Technologies € 440.000,00 2226 GR‐2009‐1599718 Molecular and expression analysis of LKB1 in prostate cancer 22,5 biomedica Oncology 1 ‐ Basic Translational € 297.000,00 2227 GR‐2009‐1605026 Immune and metabolic control of cancer growth: a novel biological system to study the immunotherapeutic role of leptin in cancer 22,5 biomedica Immunology € 600.000,00 2228 GR‐2009‐1607183 Successful aging: definition and validation of a multidimensional model. 22,5 clinico assistenziale Population Sciences and Epidemiology € 444.450,00 2229 GR‐2009‐1607429 Effect of a new isoform of Superoxide Dismutase in the prevention and treatment of Malaria, prospectus of a new therapy methodology 22,5 clinico assistenziale Infectious Diseases and Microbiology € 346.000,00 2230 GR‐2009‐1532549 Genetics of alcohol dependence and depressive disorders: towards ad hoc therapy 22,5 biomedica Genes, Genomes and Genetics € 600.000,00 Pagina 196 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2231 GR‐2009‐1583789 Evaluation of digital images acquired by computed tomography and magnetic resonance in virtual autopsy: new knowledge by the observation of a sample 22,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 190.000,00 2232 RF‐2009‐1538797 Identification of genetic markers of neoplastic progression in IBD 22,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 187.380,00 2233 GR‐2009‐1606151 Arginine metabolites in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD): new insights into the identification of biomarkers of susceptibility and progression of the disease. 22,5 biomedica Cardiovascular and Respiratory Sciences € 180.000,00 2234 GR‐2009‐1578793 CAREMORE‐LUNG: a population‐based study on lung cancer from tobacco to rehabilitation 22,5 clinico assistenziale Population Sciences and Epidemiology € 480.000,00 2235 GR‐2009‐1526888 Set your movements free! Expectation‐induced enhancement of motor recovery 22,5 biomedica Biobehavioral and Behavioral Processes € 515.000,00 2236 GR‐2009‐1578516 Emotional mechanisms in Williams Sindrome investigated by a multidisciplinary approach. Neuropsychological, neurophysiologic, functional neuroimaging, and neurobehavioral studies. 22,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 669.000,00 2237 GR‐2009‐1530015 INVESTIGATING MOLECULAR EPIDEMIOLOGY AND GENOMIC DIVERSITY OF BACILLUS ANTHRACIS IN ITALY BY WHOLE GENOME SNP ANALYSIS AND MLVA 22,5 biomedica Veterinary ‐ Animal Health ‐ ANHE € 390.200,00 2238 GR‐2009‐1574832 Alterations of bone mineral metabolism in young women with chronic bowel diseases. The pathogenetic role of serotonin and cytokines and the influence of nutritional and vitamin D deficiencies. 22,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 484.000,00 2239 GR‐2009‐1577737 Reperfusion injury after cerebral ischemia treated with thrombolysis: an in vivo study using biological and neuro‐imaging markers 22,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 235.000,00 2240 RF‐2009‐1538641 Genetic determinants of left ventricular hypertrophy 22,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 400.000,00 2241 GR‐2009‐1576587 Food safety: emergence of vancomycin‐resistant Staphylococcus aureus (VRSA) 22,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 355.000,00 Pagina 197 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2242 RF‐2009‐1530451 Analysis of the pathogenetic mechanisms underlying Mental Retardation: identification of prognostic factors and therapeutic targets 22,5 biomedica Brain Disorders and Clinical Neuroscience 2243 GR‐2009‐1604358 The Impact of Pulmonary Rehabilitation on Exertional Dyspnea in patients with Mild Chronic Obstructive Pulmonary Disease 22,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 177.283,00 2244 GR‐2009‐1525398 In vitro effects of hypoxia on murine osteocytes 22,5 biomedica Cell Biology € 164.250,00 2245 GR‐2009‐1608786 Adoptive Immunotherapy Strategies for Relapsed or Metastatic Bone Sarcomas: Preclinical models and Clinical Applications. 22,5 clinico assistenziale Immunology € 280.000,00 2246 RF‐2009‐1498641 Bone mineral and body composition analyses in infants with different intrauterine growth: early detection of alterations for an effective prevention of osteoporosis and metabolic disturbances. 22,5 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 420.000,00 2247 RF‐2009‐1486879 Modulators of the mTOR pathway in sarcomas: a genetic RNAi approach 22,5 biomedica Oncology 1 ‐ Basic Translational € 556.000,00 2248 GR‐2009‐1604861 Understanding the role of L‐arginine metabolism in mammary carcinogenesis 22,6 biomedica Oncology 1 ‐ Basic Translational € 429.550,00 2249 RF‐2009‐1528553 FETAL ALCOHOL SYNDROME: THE DAMAGE ASSOCIATED WITH PRENATAL ALCOHOL EXPOSURE IN HUMANS AND IN AN ANIMAL MODEL 22,67 biomedica Integrative, Functional, and Cognitive Neuroscience € 594.000,00 2250 GR‐2009‐1566453 In vivo silencing of autophagic genes (Atg) by electroporation‐mediated transfection. A promising target therapy to improve chemosensitivity of tumour cells. 22,67 biomedica Oncology 1 ‐ Basic Translational € 520.000,00 2251 RF‐2009‐1532409 Morbid Obesity. Prospective cohort study with analysis of treatment (medical or surgical), evaluation of outcome predictors and assessment of cardiovascular and liver disease risk . 22,67 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 365.000,00 2252 GR‐2009‐1606514 RECONSTRUCTION OF EPIDEMIOLOGICAL LINKS AND TRANSMISSION OF PRIMARY RESISTANCE TO ANTIRETROVIRALS IN A DENSE HIV‐1 POPULATION BY MOLECULAR PHYLODYNAMICS 22,75 biomedica AIDS and Related Research € 193.000,00 € 600.000,00 Pagina 198 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2253 GR‐2009‐1579951 ACUTE INFLAMMATORY LEUKOENCEPHALOPATHIES OF VARIOUS ORIGIN: MULTIDISCIPLINARY STUDY ON AETIOPATHOGENETIC MECHANISMS AND IDENTIFICATION OF DISEASE MARKERS 22,75 biomedica Brain Disorders and Clinical Neuroscience € 420.000,00 2254 GR‐2009‐1607856 The emerging problem of malignant mesothelioma in Emilia Romagna region: observational increasing incidence and need for identification of therapy‐related predictive markers 22,75 biomedica Oncology 1 ‐ Basic Translational € 552.000,00 2255 RF‐2009‐1526400 Construction of an ICT setting for the facilitation of home functional rehabilitation through motor‐cognitive therapies 22,75 clinico assistenziale Healthcare Delivery and Methodologies € 350.000,00 2256 GR‐2009‐1553706 PSY‐GE (Psychology and genetics): A study on the relationship between Psychoeducation, SNPs, side effects and adherence to improve compliance, quality of life and health in People with schizophrenia 22,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 328.400,00 2257 GR‐2009‐1475860 Development of new techniques to investigate brain iron from imaging data 22,75 biomedica Brain Disorders and Clinical Neuroscience € 358.000,00 2258 RF‐2009‐1472057 Regional‐based registry of Pervasive Developmental Disorders in Italy: prevalence estimation of autism and survey of diagnostic tools and health services 22,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 357.667,00 2259 RF‐2009‐1472881 Designing an antibody based therapy for an effective eradication of Ewing sarcoma. Selective delivery of radionuclide and immunostimulatory cytokines to tumor cells using a human monoclonal antibody in single chain fragment variable (scFv) format showi 22,75 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 2260 RF‐2009‐1471381 NATURAL PRODUCTS WITH ANTI‐MICROBIAL ACTIVITY AND THEIR INTERACTION WITH THE IMMUNE SYSTEM: IN VITRO AND IN VIVO STUDIES FOR THE EVALUATION OF NEW THERAPEUTICAL TOOLS 22,75 biomedica Immunology € 558.800,00 2261 RF‐2009‐1474564 Evaluation of an innovative rehabilitative approach in a multimodal setting for NSCLC post‐surgery patients. 22,75 clinico assistenziale Cardiovascular and Respiratory Sciences € 599.000,00 2262 GR‐2009‐1535973 Development of an optical diagnostic tool set based on Raman light scattering: from chemical imaging of tissue sections to real‐time tissue analysis in the surgical operation theatre 22,84 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 450.000,00 Pagina 199 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 22,84 biomedica Bioengineering Sciences and Technologies € 533.500,00 Relationship between modulation of frataxin function and iron‐independent oxidative stress related to the cytosolic phospholipase A2/arachidonic acid pathway. 23 biomedica Molecular, Cellular, and Developmental Neuroscience € 500.000,00 2265 RF‐2009‐1546777 Does "emotional" rehabilitation affect expression/recognition of emotional facial expressions and EEG markers (alpha rhythms, event‐related potentials) in mild cognitive impairment patients with depression? An innovative methodological approach based on s 23 clinico assistenziale Brain Disorders and Clinical Neuroscience € 495.000,00 2266 GR‐2009‐1555559 Effect of polyphenols‐rich extra virgin olive oil on childhood obesity: making the connection between inflammation and insulin resistance. 23 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 456.000,00 2267 GR‐2009‐1580934 An innovative approach to the development and validation of Biomarkers of Autism: a challenge for diagnosis and follow up of children, contributing to understand the molecular mechanisms of the different clinical forms 23 clinico assistenziale Biobehavioral and Behavioral Processes € 200.000,00 2268 RF‐2009‐1536278 DEVELOPMENT OF FORMULATION OF ZOLEDRONIC ACID ENCAPSULATED IN LIPOSOME: A NEW OPPORTUNITY AGAINST CANCER 23 biomedica Oncology 2 ‐ Translational Clinical € 478.500,00 2269 GR‐2009‐1606110 Role of the Vascular Endothelial Growth Factor (VEGF) as predictor of failure of mechanical abrasion in treatment of primary spontaneous pnemothorax 23 clinico assistenziale Cardiovascular and Respiratory Sciences € 170.445,00 2270 GR‐2009‐1591040 THE EFFICACY OF COGNITIVE REMEDIATION IN PSYCHIATRIC DISORDERS 23 clinico assistenziale Brain Disorders and Clinical Neuroscience € 262.094,00 2271 GR‐2009‐1592195 Induction of fetal haemoglobin in primary erythroid cells using new pharmacological agents: a model for the treatment of haemoglobinopathies 23 biomedica Vascular and Hematology € 378.000,00 2272 GR‐2009‐1576869 Development of an affinity‐based enrichment protocol for isolating subproteomes for diagnostic/prognostic and drug therapy evaluation purposes 23 biomedica Interdisciplinary Molecular Sciences and Training € 470.000,00 2273 RF‐2009‐1524248 PHASE II PROSPECTIVE TRIAL: HIFU FOCAL THERAPY FOR LOCALISED PROSTATE CANCER 23 clinico assistenziale Digestive, Kidney and Urological Systems € 229.000,00 2263 RF‐2009‐1536215 Harmonization and standardization of biobanking activities: definition of guidelines and operating procedures 2264 RF‐2009‐1544319 Pagina 200 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2274 GR‐2009‐1555287 CLINICAL AND INSTRUMENTAL EVALUATION OF A LOCAL INTRAOPERATIVE DRUG THERAPY TO IMPROVE PRIMARY STABILITY IN TOTAL KNEE REPLACEMENT 23 clinico assistenziale Musculoskeletal, Oral and Skin Sciences 2275 GR‐2009‐1594710 RNA‐Seq transcriptome analysis of Mid2 null and wild‐type murine embryonic Heart and Thymus. 23 biomedica Biology of Development and Aging € 195.300,00 2276 RF‐2009‐1530996 THERAPEUTIC POTENTIAL OF MULTIPOTENT MESENCHYMAL STEM CELLS (MSCs) IN CROHN'S DISEASE, A TYPICAL PRE‐CANCEROUS CHRONIC INFLAMMATION WITH INCREASING INCIDENCE: Evaluation of MSCs regulatory role on immune cells in vivo and ex vivo. 23 biomedica Digestive, Kidney and Urological Systems € 471.000,00 2277 RF‐2009‐1511123 Primary care practice‐based Emergency Department outpatient clinic: working at the interface between hospital and community. 23 clinico assistenziale Healthcare Delivery and Methodologies € 220.000,00 2278 RF‐2009‐1527581 Standardization of molecular methods to genetic individuation of ovine and bovine subjects belonging to typical italian species. Study of the microsatellite patterns, data analysis for forensic and parentage verification approach. 23 biomedica Veterinary ‐ Food Safety ‐ FOSA € 540.000,00 2279 GR‐2009‐1594501 Iodinated contrast media acute renal failure: Molecular mechanisms of cell damage and identification of novel early biomarkers and new potential therapeutic molecules. 23 biomedica Digestive, Kidney and Urological Systems € 590.000,00 2280 GR‐2009‐1606725 Effect of electromagnetic field (EMFs) on the Alzheimer disease progression: a long‐term exposition study. 23 clinico assistenziale Brain Disorders and Clinical Neuroscience € 450.000,00 2281 GR‐2009‐1604847 THE IMPACT OF DYSREGULATED RAS SIGNALING IN COGNITIVE FUNCTION 23 biomedica Molecular, Cellular, and Developmental Neuroscience € 469.700,00 2282 GR‐2009‐1584034 Role of CLIC1 in glioblastoma‐derived cancer stem cells 23 biomedica Oncology 1 ‐ Basic Translational € 453.600,00 2283 GR‐2009‐1596145 Chronic kidney disease and the cardiovascular risk in Italy 23 clinico assistenziale Population Sciences and Epidemiology € 600.000,00 2284 GR‐2009‐1553680 Functional study and detailed molecular analysis of the ABCB4 gene in human liver diseases with and without HCV infection characterized by rapid and slow hepatic fibrosis 23 biomedica Digestive, Kidney and Urological Systems € 437.000,00 € 400.000,00 Pagina 201 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2285 GR‐2009‐1578120 BIO‐INSPIRED, SUPER‐PARAMAGNETIC NANOPARTICLES FOR TARGETED THERAGNOSTIC APPLICATIONS IN MELANOMA 23 biomedica Bioengineering Sciences and Technologies € 400.000,00 2286 RF‐2009‐1511332 Anaesthesia opioid‐free and perioperative management for prevention of postoperative ileus 23 clinico assistenziale Digestive, Kidney and Urological Systems € 190.000,00 2287 RF‐2009‐1530477 Molecular mechanisms of neurogenesis alterations in mood‐related disorders. BDNF as a therapeutic target? 23 biomedica Molecular, Cellular, and Developmental Neuroscience € 380.000,00 2288 GR‐2009‐1606818 AUTOPHAGY AND APOPTOSIS AS KEY REGULATORS OF MUSCLE ATROPHY IN MYOTONIC DYSTROPHIES AND LIMB GIRDLE MUSCULAR DYSTROPHY. 23 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 355.000,00 2289 GR‐2009‐1606973 Genome‐wide association study (GWAS) and detection of novel genetic loci involved in the carcinogenesis of differentiated thyroid carcinoma (DTC). 23 biomedica Genes, Genomes and Genetics € 377.000,00 2290 GR‐2009‐1551882 A Comprehensive Approach for the Identification of Learning Disabilities 23 clinico assistenziale Emerging Technologies and Training in Neurosciences € 243.000,00 2291 GR‐2009‐1560403 Disorders on mitochondrial DNA synthesis and maintenance: clinical, histopathological and genetic study in a heterogeneous population with mitochondrial disorders 23 clinico assistenziale Genes, Genomes and Genetics € 550.000,00 2292 RF‐2009‐1549557 Acute and delayed adverse Health Effects of Airborne Particle Pollution (HEAPP): a mechanistic study of the biological effects of particles size and chemistry nested within an epidemiological cohort study among traffic police officer 23 clinico assistenziale Population Sciences and Epidemiology € 265.400,00 2293 GR‐2009‐1591308 Post‐translational modification of frataxin. Role in frataxin maturation and functions. New insights for the pathogenesis of the Friedreichs Ataxia. 23 biomedica Molecular, Cellular, and Developmental Neuroscience € 300.000,00 2294 RF‐2009‐1548348 Strategies for the identification of colorectal cancer (CRC) high risk subjects and development of tailored clinical and molecular surveillance programs 23 biomedica Oncology 2 ‐ Translational Clinical € 444.400,00 2295 GR‐2009‐1605327 Reward‐based recovery of attentional mechanisms in stroke and traumatic brain injury patients: An integrated behavioral and rTMS approach 23 clinico assistenziale Brain Disorders and Clinical Neuroscience € 536.050,00 Pagina 202 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2296 GR‐2009‐1607864 Tumor initiating colon cancer cells in human liver metastasis: technological assessment and clinical relevance 23 biomedica Oncology 1 ‐ Basic Translational € 457.000,00 2297 GR‐2009‐1493240 Modulation of Ischemia/reperfusion damage during human liver transplantation using anti‐lymphocyte T polyclonal antibodies 23 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 182.500,00 2298 RF‐2009‐1472324 RAGE/insulin signalling interactions: new pathway linking inflammation to insulin resistance 23 biomedica Cell Biology € 167.500,00 2299 RF‐2009‐1499725 Modulation of genes G‐protein signaling modulator in vascular endothelium regulating the mechanism of vasodilatation: a role in arterial hypertension 23 biomedica Vascular and Hematology 2300 RF‐2009‐1474872 Triage test combined with the p16INK4a‐Ki‐67 in screening cervical cancer with HPVDNA‐TEST 23 biomedica Risk, Prevention and Health Behavior € 156.000,00 2301 RF‐2009‐1500905 Innovative molecular imaging to assess the tumorigenic potential of feline mammary carcinoma stem cells 23 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 2302 GR‐2009‐1573479 Congenital hyperinsulinism of infancy: clinical and metabolic evaluation, genetic characterization, identification of candidate genes, national registry and role of hyperinsulinemic hypoglycemia in the Apparent Life Threatening Events (ALTE) and Sudden In 23,17 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 530.000,00 2303 RF‐2009‐1511645 Neurofunctional evaluation of low level consciousness patients 23,17 clinico assistenziale Brain Disorders and Clinical Neuroscience € 450.000,00 2304 RF‐2009‐1550805 Philadelphia‐negative Myeloproliferative Neoplasms: new molecular approaches for translational research and patients clinical management through the creation of a regional network. 23,17 biomedica Oncology 1 ‐ Basic Translational € 307.000,00 2305 RF‐2009‐1546440 Implementation of a multidisciplinary network for the prevention, early diagnosis and clinical care of vertically transmitted infections 23,25 clinico assistenziale Healthcare Delivery and Methodologies € 400.000,00 2306 GR‐2009‐1560049 Arrhythmogenic Right Ventricular Cardiomyopathy: In The Research Of Clinical And Molecular Prognostic Markers 23,25 biomedica Cardiovascular and Respiratory Sciences € 286.208,30 € 290.000,00 Pagina 203 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2307 GR‐2009‐1546104 Modeling progression of colorectal cancer via pathway dependencies 23,25 biomedica Genes, Genomes and Genetics € 450.000,00 2308 GR‐2009‐1580367 Investigating the role of placebo and nocebo effects in migraine 23,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 572.000,00 2309 GR‐2009‐1555162 Characterization of Transcranial Magnetic Stimulation (TMS) response in patients with Major Depression: the influence of genetic and epigenetic patterns 23,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 316.000,00 2310 GR‐2009‐1604428 THE VENOUS OXYGEN SATURATION (VOXSAT) PEDIATRIC CARDIAC SURGERY TRIAL 23,25 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 150.000,00 2311 RF‐2009‐1526375 DEVELOPMENT OF AN INTEGRATED BIOSTATISTICS AND BIOINFORMATICS FRAMEWORK FOR CLINICAL TRANSLATION AND EVALUATION OF NEW BIOMARKER TECHNOLOGIES 23,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 165.000,00 2312 GR‐2009‐1488730 TREATMENT OF PERITONEAL CARCINOMATOSIS WITH CYTOREDUCTIVE SURGERY AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (HIPEC): STUDY OF FACTORS ASSOCIATED WITH THE THERAPEUTIC RESPONSE. 23,25 biomedica Oncology 2 ‐ Translational Clinical € 193.500,00 2313 RF‐2009‐1532471 Study of the risks related to Listeria monocytogenes in dairy products: detection, molecular typing and use of bacteriocin‐producing Lactic Acid Bacteria to reduce the contamination. 23,34 biomedica Veterinary ‐ Food Safety ‐ FOSA € 564.000,00 2314 GR‐2009‐1576363 Pathogenicity and clincal impact of emerging pathogens 23,34 biomedica Infectious Diseases and Microbiology € 600.000,00 2315 GR‐2009‐1594927 Artificial Neural Network in development of Innovative diagnostic systems for Carotid Atherosclerosis: the ANN‐ICA study 23,34 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering 2316 RF‐2009‐1538529 The role of semaphorins in the progression of chronic liver injury: from fibrosis to hepatocellular carcinoma 23,34 biomedica Oncology 1 ‐ Basic Translational € 268.600,00 2317 RF‐2009‐1532282 Outcome indicators in pediatric hospital care 23,34 clinico assistenziale Healthcare Delivery and Methodologies € 300.000,00 € 315.638,00 Pagina 204 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2318 RF‐2009‐1538734 Farm‐Community model and Autism in adolescent and young adult subjects 23,5 clinico assistenziale Healthcare Delivery and Methodologies € 280.000,00 2319 RF‐2009‐1546781 Development of an index, registry and research based networking for pediatric biobanks 23,5 biomedica Genes, Genomes and Genetics € 235.000,00 2320 RF‐2009‐1539549 Health Technology Assessment (HTA) of Amplatzer Cardiac Plug (ACP) for Left Atrial Appendage Embolization in patients with non‐valvular Atrial Fibrillation (AF) with High Risk for Oral Anticoagulant Therapy (CHADS2 score). 23,5 clinico assistenziale Healthcare Delivery and Methodologies € 190.000,00 2321 GR‐2009‐1607627 Understanding and translating into the clinical approach the underlying mechanisms of non conventional medicine in the therapy of pain: the western scientific approach in the service of eastern medicine (EASTWESTHOSTILE to PAIN) 23,5 clinico assistenziale Emerging Technologies and Training in Neurosciences 2322 RF‐2009‐1549339 Three key drugs in newborns: a novel approach for micro‐dosing by means of advanced mass spectrometry techniques 23,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 280.000,00 2323 GR‐2009‐1538021 Understanding the physiopathology of endogenous stem cells to boost their efficacy as endogenous therapeutics for muscle diseases 23,5 biomedica Musculoskeletal, Oral and Skin Sciences € 416.000,00 2324 GR‐2009‐1607310 Implementation of an organizational model in the care pathways of people with eating disorders: filters definition and operational policy 23,5 clinico assistenziale Healthcare Delivery and Methodologies 2325 RF‐2009‐1550388 Chemical contamination of foods and the Italian consumer's risk assessment through the ONR‐OICA database 23,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 428.700,00 2326 GR‐2009‐1605044 The role of apoptosis and autophagy in the pathogenesis and progression of Rheumatoid Arthritis. 23,5 biomedica Immunology € 582.000,00 2327 RF‐2009‐1531297 SYNBIO TRIAL: RANDOMIZED CONTROLLED TRIAL ON THE USE OF SYNTHETIC VS BIOSYNTHETIC PATCH FOR THE TREATMENT OF CONGENITAL DIAPHRAGMATIC HERNIA 23,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 200.000,00 2328 GR‐2009‐1607754 An Open‐label, Single Center, Randomized, 2‐arm Study to Investigate the Impact of Serum Free‐Light Chain Removal by High Cutoff Hemodialysis versus Conventional Plasma Exchange in Acute Renal Failure due to Cast Nephropathy 23,5 clinico assistenziale Digestive, Kidney and Urological Systems € 0,00 € 88.500,00 € 153.000,00 Pagina 205 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2329 GR‐2009‐1592230 A first level screening test for 22q11.2 microalterations detection in patients with congenital heart disease 23,5 biomedica Genes, Genomes and Genetics € 346.400,00 2330 GR‐2009‐1492745 The role of Osteopontin and SPARC towards development of androgen‐ independent prostate cancer 23,5 biomedica Oncology 1 ‐ Basic Translational € 330.880,00 2331 GR‐2009‐1470959 Pilot study of Lokomat versus manual‐assisted with body weight support on the treadmill training for gait recovery in Parkinsonian patients. 23,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 495.000,00 2332 RF‐2009‐1473654 MOLECULAR MECHANISMS OF CHEMOSENSIBILIZATION TO THE ACTION OF CISPLATIN IN MESOTHELIOMA THERAPY 23,5 biomedica Oncology 1 ‐ Basic Translational € 350.000,00 2333 GR‐2009‐1596613 Inhibition of phosphatidylcholine‐specific phospholipase C as a new strategy to counteract tumor‐promoting inflammation 23,67 biomedica Oncology 1 ‐ Basic Translational € 415.000,00 2334 GR‐2009‐1605493 Two hits one goal: lentiviral synapsin I gene delivery and ATF4/CREB‐2 gene silencing. An integrative approach to counteract the alpha‐synuclein‐induced neuronal derangement in Parkinson disease 23,67 biomedica Brain Disorders and Clinical Neuroscience € 195.000,00 2335 RF‐2009‐1523548 Phenotypic and molecular characterization aimed at chemosensitization of hormone‐independent prostate cancer models 23,67 biomedica Oncology 1 ‐ Basic Translational € 425.700,00 2336 RF‐2009‐1538302 New prognostic tools of cardiovascular events in patients undergone to prosthetic heart valve implantation 23,67 biomedica Cardiovascular and Respiratory Sciences € 599.500,00 2337 RF‐2009‐1504462 Nanomedicine applied to cerebral ischemia 23,67 biomedica Bioengineering Sciences and Technologies € 596.500,00 2338 RF‐2009‐1524120 Characterization of autophagy role in HIV‐infected LTNP 23,75 biomedica AIDS and Related Research € 321.000,00 2339 GR‐2009‐1594911 PRO‐SHOULD Project for a comprehensive assessment of shoulder function outcome measures: development of a new three‐dimensional (3D) model, for research including technology, using an optoelectronic‐based motion analysis system as gold standard for identi 23,75 clinico assistenziale Musculoskeletal, Oral and Skin Sciences € 283.000,00 2340 RF‐2009‐1538708 Innovative approaches for disease management of difficult to treat tuberculosis patients in a low burden context 23,75 clinico assistenziale Infectious Diseases and Microbiology € 243.428,00 Pagina 206 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2341 RF‐2009‐1475124 Evaluation of the inhibitory effect of specific blocking antibody and the modulatory action of high molecular weight Hyaluronan of CD44 and Toll‐like receptors on diabetic complications in congenic diabetic mice and streptozotocin‐ induced diabetes in mice 23,75 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 177.000,00 2342 RF‐2009‐1472337 Efficacy of transcranial Direct Current Stimulation (tDCS) in the treatment of paediatric pharmaco‐resistant focal epilepsy 23,75 biomedica Brain Disorders and Clinical Neuroscience € 150.000,00 2343 RF‐2009‐1549669 Role of master transcription factors in regulating tumor‐microenvironment interaction and survival programs in human melanoma 23,84 biomedica Oncology 1 ‐ Basic Translational € 196.900,00 2344 GR‐2009‐1606754 Generation of neuronal cellular models from skin fibroblasts to study the relevance of iron homeostasis alterations in the pathogenesis of Pantothenate Kinase Associated Neurodegeneration. 24 biomedica Molecular, Cellular, and Developmental Neuroscience € 540.000,00 2345 GR‐2009‐1606593 Diagnosis of attention‐deficit/hyperactivity disorder (ADHD) in children by quantitative EEG and transcranial magnetic stimulation markers. 24 biomedica Biobehavioral and Behavioral Processes € 450.000,00 2346 RF‐2009‐1535928 Trans Oral Robotic versus Open Tongue Base Reduction & SupraGlottoPlasty for adult Obstructive Sleep Apnea Hypopnea Syndrome :A Randomised Controlled Trial 24 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 351.000,00 2347 GR‐2009‐1606632 Molecular markers for prediction or early diagnosis of colorectal cancer 24 biomedica Population Sciences and Epidemiology € 599.500,00 2348 GR‐2009‐1606592 Prognostic biomarkers for the level of circulating Endothelial Progenitor Cells (EPCs) in a cohort of healthy donors, pre‐diabetic and type 2 diabetic patients. 24 biomedica Genes, Genomes and Genetics € 463.800,00 2349 GR‐2009‐1606751 Relationship between mitochondrial genetic load and visual system abnormalities in migraine 24 clinico assistenziale Brain Disorders and Clinical Neuroscience € 506.900,00 2350 GR‐2009‐1594512 Volumetric breast density by MRI as a predictor of breast cancer: a 6‐year prospective study 24 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 300.000,00 2351 GR‐2009‐1578362 Added value of MR Spectroscopy in the screening, diagnosis and follow‐up of Cardiac involvement in patients with Anderson‐Fabry disease 24 clinico assistenziale Cardiovascular and Respiratory Sciences € 390.000,00 Pagina 207 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2352 GR‐2009‐1606862 Molecular analysis of LTBP2, the new gene associated with Primay Congenital Glaucoma, in Italian patients without CYP1B1 mutations. 24 biomedica Genes, Genomes and Genetics 2353 RF‐2009‐1551325 Molecular imprinting on electrospun scaffolds for cardiovascular disease 24 biomedica Cardiovascular and Respiratory Sciences € 599.500,00 2354 GR‐2009‐1580039 Identification of Novel Akt Substrates and Binding Partners During Myogenesis by a Functional Proteomic Approach: Benefits for Diagnosis and Symptoms Attenuation in Primary and Secondary Myopathies. 24 biomedica Musculoskeletal, Oral and Skin Sciences € 345.000,00 2355 RF‐2009‐1539944 Genotypes of Toxoplasma gondii present in Central Italy, their pathogeneticity and transmission among wildlife, livestock and humans. Are the ectoparasites an additional natural source of infection? 24 biomedica Veterinary ‐ Animal Health ‐ ANHE € 440.000,00 2356 GR‐2009‐1577865 Identification of novel prognostic factors and potential therapeutic targets for post operative atrial fibrillation 24 biomedica Cardiovascular and Respiratory Sciences € 552.000,00 2357 GR‐2009‐1538891 Efficacy of psychological support interventions tailored to caregivers of patients with stroke, heart failure or chronic obstructive pulmonary disease undergoing a rehabilitation program: a pilot study. 24 clinico assistenziale Risk, Prevention and Health Behavior € 355.000,00 2358 GR‐2009‐1594782 Health risk assessment for Lyme disease and TBE in Italy and possible introduction of CCHF 24 biomedica Infectious Diseases and Microbiology € 280.400,00 2359 GR‐2009‐1604424 From Aß deposition to synaptic dysfunction in the TgCRND8 mouse: in vitro and in vivo studies of the molecular, cellular and functional alterations 24 biomedica Molecular, Cellular, and Developmental Neuroscience € 467.000,00 2360 GR‐2009‐1605783 Integration of DCE‐MRI, DWI and MRSI for early evaluation of response to neoadjuvant therapy in locally advanced breast cancer patients. 24 biomedica Bioengineering Sciences and Technologies € 600.000,00 2361 RF‐2009‐1546927 Stem cells derived from lipoaspirate of transplanted patients: future for tissues regeneration 24 biomedica Biology of Development and Aging € 480.000,00 2362 GR‐2009‐1608561 Identification and characterization of putative tumour suppressor miRNAs for replacement therapy 24 biomedica Oncology 2 ‐ Translational Clinical € 401.960,00 € 73.000,00 Pagina 208 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2363 RF‐2009‐1549524 Role of anti‐lymphocytes autoantibodies in autoimmunity and in lymphomagenesis 24 biomedica Immunology € 355.000,00 2364 RF‐2009‐1524065 HEALTH AND SAFETY OF WORKERS RELATED TO AGEING AND CHANGE IN THE PRODUCTIVE SYSTEMS AND SOCIAL POLICIES 24 clinico assistenziale Population Sciences and Epidemiology € 500.000,00 2365 GR‐2009‐1605091 Liposomal drug delivery system in the treatment of Pertiodontal diseases 24 biomedica Infectious Diseases and Microbiology € 472.000,00 2366 GR‐2009‐1605080 Interaction between genetic predisposition and inflammation in sporadic amyotrophic lateral sclerosis : identification of novel therapeutic targets to reduce motor neuron vulnerability 24 biomedica Molecular, Cellular, and Developmental Neuroscience € 435.000,00 2367 RF‐2009‐1476226 Rejuvenating Cardiac Stem Cells 24 biomedica Cardiovascular and Respiratory Sciences € 530.000,00 2368 GR‐2009‐1472868 Assessment of the hygienic and health status of fish and molluscs bred in aquaculture plants counted in Campania Region (Italy), under the microbiological, parasitological and chemical‐toxicological aspects. 24 biomedica Veterinary ‐ Food Safety ‐ FOSA € 260.000,00 2369 RF‐2009‐1493245 Assessing the effect of intensive neurorehabilitation treatment (IRT) on neurotrophic factors production and dopamine transmission in patients with newly diagnosed Parkinsons disease 24 clinico assistenziale Brain Disorders and Clinical Neuroscience € 308.000,00 2370 GR‐2009‐1469929 Layer‐specific genes as neuronal markers for diagnosis and pathogenesis of malformations of cortical development: a combined study on human and animal model 24 biomedica Brain Disorders and Clinical Neuroscience € 500.005,00 2371 RF‐2009‐1474528 S. aureus and L. monocytogenes in food and environment: new methods to assess biofilm formation in order to verify efficacy of sanitizing agents to reach a high hygiene level in food producing processes and risk analysis on cross contamination with comm 24 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 2372 RF‐2009‐1502052 Role of respiratory viral infections in asthma exacerbations: clinical and therapeutic implications. 24 clinico assistenziale Infectious Diseases and Microbiology € 150.000,00 2373 RF‐2009‐1498640 Autism Spectrum Disorder: a new approach to the management of Rett syndrome based on administration of omega ‐ 3 LC ‐ PUFAs 24 clinico assistenziale Biobehavioral and Behavioral Processes € 249.150,00 Pagina 209 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2374 RF‐2009‐1504155 Text Mining and the Public Health System. Mining Public Health Databases to Enhance the Quality of Health Care 24 clinico assistenziale Healthcare Delivery and Methodologies € 483.000,00 2375 GR‐2009‐1491709 Development of efficient gene expression and protein secretion system in non‐ pathogenic gram positive Lactobacillus for Canine parvovirus infection in puppies 24 biomedica Veterinary ‐ Animal Health ‐ ANHE € 412.000,00 2376 RF‐2009‐1492047 Developing therapeutic strategies that support astrocyte function as new avenues in the treatment of neurodegenerative diseases: focus on Parkinson's disease 24 biomedica Brain Disorders and Clinical Neuroscience € 500.000,00 2377 RF‐2009‐1505389 Study of role of the Aryl Hydrocarbon Receptor (AHR) in the activation of apoptosis in cancer cells 24 biomedica Oncology 2 ‐ Translational Clinical € 550.000,00 2378 RF‐2009‐1472420 Megalencephalic leukoencephalopathy with subcortical cysts: new insights on MLC1 function and therapeutic developments. 24 biomedica Molecular, Cellular, and Developmental Neuroscience € 374.000,00 2379 RF‐2009‐1549675 Realization of a Bio‐Bank for Rare Ocular Disease 24,17 biomedica Cell Biology € 600.000,00 2380 RF‐2009‐1511495 CRYPTOgeNetic Ischemic stroke and atrial Tachyarrhythmic Events (CRYPTONITE) 24,17 clinico assistenziale Cardiovascular and Respiratory Sciences € 597.000,00 2381 RF‐2009‐1544962 Health and environmental issues of asbestos fibres in natural and human context. Biological studies by in vitro screening for mineral pathogenicity after mineralogical characterization of Ca‐Fe‐Mg‐amphiboles and thermal transformed cement‐asbestos materia 24,17 biomedica Oncology 1 ‐ Basic Translational € 575.000,00 2382 RF‐2009‐1537400 Role of immune‐inflammation in the normal and pathological ageing. 24,17 biomedica Biology of Development and Aging € 470.000,00 2383 GR‐2009‐1603041 screening programs of dysphagia 24,25 clinico assistenziale Biobehavioral and Behavioral Processes € 150.000,00 2384 RF‐2009‐1550126 Action and object observation treatment in rehabilitation of cerebral palsy 24,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 372.000,00 2385 GR‐2009‐1608533 Novel global measures for an eEarly and safe use of antibiotic therapy in severe infections in ICU with respect of to emerging antimicrobial resistance patterns: development of a computer decision support system for Italian Intensive Care Units. 24,25 clinico assistenziale Infectious Diseases and Microbiology € 198.000,00 Pagina 210 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2386 RF‐2009‐1471739 Environmental exposure of the Italian population to toxicants and/or endocrine disrupters: Identification and development of gene expression biomarkers. 24,25 biomedica Genes, Genomes and Genetics € 600.000,00 2387 RF‐2009‐1548258 WAKE‐UP ISCHEMIC STROKE: CLINICAL, NEUROSONOLOGICAL AND RADIOLOGICAL FEATURES, INCLUDING PERFUSIONAL CT 24,34 clinico assistenziale Brain Disorders and Clinical Neuroscience € 200.000,00 2388 RF‐2009‐1547405 Role of the nociceptin/orphanin FQ‐NOP receptor system in immune‐ and glia‐ mediated regulation of neuronal functions: search of novel drugs for neurophatic pain control 24,34 biomedica Integrative, Functional, and Cognitive Neuroscience € 445.500,00 2389 GR‐2009‐1606746 Repeated influenza A infections as a risk factor for the development of neurodegenerative diseases, including Parkinsons disease 24,5 biomedica Infectious Diseases and Microbiology € 500.000,00 2390 GR‐2009‐1607710 OFF‐PUMP, BEATING HEART, MITRAL VALVE REPAIR 24,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 205.000,00 2391 GR‐2009‐1601012 Maspin expression and function in melanoma: evaluation of maspin as new prognostic marker and a therapeutic target for melanoma patients 24,5 biomedica Oncology 2 ‐ Translational Clinical € 290.000,00 2392 GR‐2009‐1606645 Identification of metabolic pathways and genes affected by FUS RNA‐binding protein dysfunction in Amyotrophic Lateral Sclerosis 24,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 352.000,00 2393 GR‐2009‐1577534 Telemedicine based management model for Amyotrophic Lateral Sclerosis patients 24,5 clinico assistenziale Healthcare Delivery and Methodologies € 561.150,00 2394 GR‐2009‐1578183 A functional study on implications of PPAR gene polymorphisms in AD 24,5 biomedica Genes, Genomes and Genetics € 315.785,00 2395 RF‐2009‐1530859 Spinal and supraspinal functional, biomolecular and morphofunctional changes in a model of neuropathic pain in the mouse: recovery perspectives by transplantation of human mesenchymal stem cells in the prelimbic cortex. 24,5 biomedica Biobehavioral and Behavioral Processes € 260.000,00 2396 GR‐2009‐1603040 Identification of genetic variants associated with atherothrombotic vascular risk in cardiosurgery patients 24,5 biomedica Risk, Prevention and Health Behavior € 500.000,00 2397 RF‐2009‐1511121 Farmed mussels (Mytilus galloprovincialis) diseases as environmental biomarkers. 24,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 Pagina 211 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2398 RF‐2009‐1524656 Innovative immunotherapeutic protocols for the treatment of HER‐2+ cancer patients 24,5 biomedica Oncology 2 ‐ Translational Clinical € 220.000,00 2399 GR‐2009‐1591312 Evaluation of large‐scale brain networks connectivity in mild cognitive impairment as a marker to track Alzheimers disease progression 24,5 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 2400 GR‐2009‐1569582 Marteilia refringens biomonitor in captive and cultured mussel (Mytilus galloprovincialis) population in Campania region: etiology, phases of the infection, temporal and spatial variability in prevalence 24,5 biomedica Veterinary ‐ Animal Health ‐ ANHE € 600.000,00 2401 GR‐2009‐1606146 Walking through atherosclerosis.Physical training in peripheral arterial disease: effects of an intensive treatment protocol on walking performance, redox state, inflammation, platelets and endothelial function. 24,5 clinico assistenziale Vascular and Hematology € 324.500,00 2402 GR‐2009‐1608693 Strategies of colorectal cancer screening: virtual colonoscopy versus fecal occult blood test 24,5 clinico assistenziale Digestive, Kidney and Urological Systems € 600.000,00 2403 GR‐2009‐1580410 CARDIAC STEM CELLS: FROM CELL ISOLATION, THROUGH DESIGNING A BIODEGRADABLE SCAFFOLD FOR STEM CELL THERAPY, TO A NEW SURGICAL APPROACH 24,5 biomedica Cardiovascular and Respiratory Sciences € 423.000,00 2404 RF‐2009‐1505794 INNOVATIVE TOOLS FOR THE STUDY, DIAGNOSIS AND TREATMENT OF NEUROVASCULAR DISEASE AND COGNITIVE IMPAIRMENT 24,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 500.000,00 2405 GR‐2009‐1580311 New diagnostic approaches for identification of known and new viruses in cell cultures and biological samples 24,5 clinico assistenziale Healthcare Delivery and Methodologies € 450.000,00 2406 GR‐2009‐1583917 THE NETWORK OF MOLECULAR INTERACTIONS UNDERLYING LIVER REGENERATION: A NEW ROAD FOR THE SUCCESS OF LIVER CELL TRANSPLANTATION. 24,5 biomedica Digestive, Kidney and Urological Systems € 570.900,00 2407 RF‐2009‐1539774 Welfare assessment of horses on farm and during transport 24,5 biomedica Veterinary ‐ Animal welfare ‐ ANWE € 242.555,00 2408 GR‐2009‐1607903 END OF LIFE DECISION STUDY ( E.L.D.Y. PROJECT) 24,5 clinico assistenziale Population Sciences and Epidemiology € 170.000,00 Pagina 212 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2409 GR‐2009‐1566927 Radiotherapy Response prediction in cancer: from the genetic code into the clinics 24,5 biomedica Oncology 2 ‐ Translational Clinical 2410 GR‐2009‐1608626 OBESITY IN PREGNANCY: OXIDATIVE AND NITROSATIVE STRESS IN PLATELETS AND LIPOPROTEINS 24,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 344.000,00 2411 RF‐2009‐1475808 Inflammation, angiogenesis and microRNA in malignant mesothelioma. 24,5 biomedica Oncology 1 ‐ Basic Translational € 295.000,00 2412 RF‐2009‐1485982 Molecular signature of circulating osteogenic stem cells: clinical relevance for bone regenerative medicine 24,5 biomedica Musculoskeletal, Oral and Skin Sciences € 594.000,00 2413 RF‐2009‐1504367 A neuroscientific study of the factors leading to cognitive decline, and the treatment of cognitive symptoms following stroke 24,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 358.000,00 2414 RF‐2009‐1486949 Development and validation of rapid tools to diagnose high impact emerging viral pathogens 24,5 clinico assistenziale Infectious Diseases and Microbiology € 600.000,00 2415 RF‐2009‐1494390 Vascular compliance before and after brachial ischemia in small‐for‐gestational‐ age children‐adolescents 24,5 clinico assistenziale Risk, Prevention and Health Behavior € 227.000,00 2416 RF‐2009‐1473590 PERSONAL, MOBILE, REUSABLE AND WIRELESS SYSTEM FOR NURSING SUPPORT DETECTING AND SIGNALING BIOMEDICAL MEASUREMENTS AND POTENTIALLY CRITICAL CONDITIONS ORIENTED TO A TIMELY INTERVETION FOR STAYING‐IN‐BED PATIENTS AND TO A BIOMEDICAL DATA BASE CREATION FOR 24,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 334.000,00 2417 RF‐2009‐1545779 BIOINFORMATIC AND BIOENGINEERING ANALYSIS TO STUDY LATE ONSET EPILEPSY 24,67 biomedica Emerging Technologies and Training in Neurosciences € 465.800,00 2418 RF‐2009‐1547311 INVOLVEMENT OF mGlu7 AND mGlu8 RECEPTORS IN NEROPATHIC PAIN: THERAPUTIC PERSPECTIVES 24,67 biomedica Molecular, Cellular, and Developmental Neuroscience € 195.000,00 2419 GR‐2009‐1592254 Evaluating the influence of genetic factors in the response to rotigotine in patients with Idiophatic Parkinsons Disease 24,75 biomedica Molecular, Cellular, and Developmental Neuroscience € 315.175,00 € 251.000,00 Pagina 213 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2420 RF‐2009‐1539489 NEW PURINERGIC STRATEGIES TO IMPLEMENT ENDOGENOUS NEUROGENESIS AND RE‐MYELINATION IN THE REPAIR OF SPINAL CORD INJURY AND BRAIN ISCHEMIA 24,75 biomedica Molecular, Cellular, and Developmental Neuroscience € 584.037,00 2421 GR‐2009‐1580125 Brain‐computer interfaces to support individual autonomy: transfer to the rehabilitation context 24,75 clinico assistenziale Emerging Technologies and Training in Neurosciences € 498.900,00 2422 RF‐2009‐1511600 Psychobiological predictors of treatment response in Panic Disorder and Obsessive‐Compulsive Disorder. 24,75 clinico assistenziale Biobehavioral and Behavioral Processes € 221.558,00 2423 RF‐2009‐1474990 Identification of genetic and epigenetic factors for patient‐tailored treatment in myelodysplastic syndromes and acute myeloid leukemia 24,75 biomedica Oncology 2 ‐ Translational Clinical € 468.000,00 2424 GR‐2009‐1600709 A recessive form of Alzheimer disease (AD) associated with a novel APP variant with dominant‐negative effect on amyloidogenesis: deciphering the molecular mechanisms underlying the opposite effects of the A673V mutation in the homozygous or heterozygous s 24,84 biomedica Molecular, Cellular, and Developmental Neuroscience 2425 RF‐2009‐1538099 Functional and Structural neuroimaging markers for early diagnosis/prognosis of Alzheimer's disease as a function of Genetic risk factors 25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 320.000,00 2426 RF‐2009‐1539285 Beyond classical neurotransmission: the potential role of novel neuromodulators in physiological and pathological brain functioning 25 biomedica Molecular, Cellular, and Developmental Neuroscience € 600.000,00 2427 RF‐2009‐1530757 Mucosal innate immunity in early phases of HIV infection: role of activated gamma/delta T cells as adjuvants enhancing protective anti‐HIV response. 25 biomedica Immunology € 548.000,00 2428 GR‐2009‐1604369 Global Warming and health risk assessment: human and animal leishmaniasis infection is growing in Italy? 25 biomedica Veterinary ‐ Animal Health ‐ ANHE € 423.000,00 2429 RF‐2009‐1548984 Proteomic and biochemical characterization of osteoblast metabolism in Adolescent Idiopathic Scoliosis 25 biomedica Musculoskeletal, Oral and Skin Sciences € 205.700,00 2430 GR‐2009‐1591253 Genetic and pathological changes induced by toxic residues in ruminats milk and their effects on public health 25 biomedica Veterinary ‐ Food Safety ‐ FOSA € 370.000,00 € 361.100,00 Pagina 214 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2431 RF‐2009‐1523902 Assessment of resistance to infections and of the effectiveness of immunomodulatory treatments to reduce the need for antimicrobials in periparturient, high‐yielding dairy cattle 25 biomedica Veterinary ‐ Animal Health ‐ ANHE € 505.000,00 2432 GR‐2009‐1591501 Obesity and cachexia in chronic heart failure insights into the interplay between metabolic changes, mechanisms of muscle wasting and exercise capacity 25 clinico assistenziale Cardiovascular and Respiratory Sciences € 425.000,00 2433 GR‐2009‐1605023 The role of cathepsin B in the cannibalic behavior of metastatic melanoma cells 25 biomedica Oncology 1 ‐ Basic Translational € 586.000,00 2434 RF‐2009‐1545784 IN VITRO PROPAGATION AND EXPANSION OF NORMAL ENDOTHELIAL PROGENITORS FROM BLOOD: A NEW TOOL FOR REGENERATIVE MEDICINE 25 biomedica Vascular and Hematology € 362.340,00 2435 GR‐2009‐1591861 Role of imaging in the evaluation of the natural history and of the efficacy of the anticancer treatment driven by nanoparticles in liver metastases of nude rats affected by colorectal carcinoma 25 biomedica Bioengineering Sciences and Technologies € 100.000,00 2436 RF‐2009‐1547794 Genetic upgrade of Emilia‐Romagna Bone Marrow Donor Registry 25 biomedica Genes, Genomes and Genetics € 491.500,00 2437 GR‐2009‐1594578 Fat tissue as source of cardiomyocytes: epigenetic and transcriptional characterization of adipose tissue derived stromal vascular fraction and of white mature adipocytes during cardiomyocyte differentiation 25 biomedica Cardiovascular and Respiratory Sciences € 392.000,00 2438 GR‐2009‐1583934 Linear and non‐linear parameterization of EEG in patients affected by senile dementia and disorders of consciousness for diagnosis and prognosis purposes 25 biomedica Bioengineering Sciences and Technologies € 174.025,00 2439 GR‐2009‐1606347 Turning expression into advantage: a new tool for regulatory T cell therapy 25 biomedica Immunology € 225.000,00 2440 RF‐2009‐1548843 Immunologic investigations in Amyotrophic Lateral Sclerosis: disease improvements need a cross‐talk among basic genetic research and immunological clinical data. 25 biomedica Immunology € 361.000,00 2441 GR‐2009‐1608122 Successful Iloprost treatment and Metabolic Profile of critical Limb ischemia in Elderly patients (SIMPLE) 25 biomedica Vascular and Hematology € 572.000,00 2442 GR‐2009‐1577869 Endothelialization of biofunctionalized human cardiac valves by endothelial progenitor cells 25 biomedica Bioengineering Sciences and Technologies € 525.000,00 Pagina 215 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2443 GR‐2009‐1548435 Study of regulatory regions of CFTR in cystic fibrosis patients bearing unknown mutations 25 biomedica Genes, Genomes and Genetics € 361.000,00 2444 RF‐2009‐1506094 Clinical and economic impact of Low Dose CT Coronary Angiography vs. Stress Imaging in the assessment of suspected Coronary Artery Disease:PARADISE Study 25 clinico assistenziale Cardiovascular and Respiratory Sciences € 484.000,00 2445 RF‐2009‐1529321 Classe V beta‐tubulin expression as biomarker in solid tumors. 25 biomedica Oncology 1 ‐ Basic Translational € 450.000,00 2446 GR‐2009‐1608278 Neuroinflammation in the pathogenesis of seizures and epilepsy: a nanomedicinal approach 25 biomedica Brain Disorders and Clinical Neuroscience € 600.000,00 2447 GR‐2009‐1591900 Hospital‐based Stroke Registry in Modena Province 25 clinico assistenziale Population Sciences and Epidemiology € 428.080,00 2448 RF‐2009‐1531078 neurometabolic correlates of non‐pharmachological intervention in social phobic patients: through a neurobiological basis of attentional bias theory of social phobia 25 biomedica Brain Disorders and Clinical Neuroscience € 300.000,00 2449 GR‐2009‐1607264 NEW PERSPECTIVES IN OVARIAN CANCER DIAGNOSIS AND CLINICAL TREATMENT DEPICTING THE BIOLOGICAL PATHWAYS WITH A REDOX PROTEOMIC APPROACH 25 biomedica Oncology 1 ‐ Basic Translational 2450 RF‐2009‐1538760 GLUCOCORTICOIDS, OXIDATIVE STRESS AND CARDIOVASCULAR RISK IN HUMANS: EVALUATION OF HYPER‐ AND HYPOCORTISOLEMIC STATES BEFORE AND AFTER REMISSION AND NEW POSSIBLE THERAPEUTIC STRATEGIES 25 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 95.000,00 2451 GR‐2009‐1607393 Biological characterization of Brain Tumor Initiating Cells and their treatment‐ resistance features. 25 biomedica Oncology 1 ‐ Basic Translational € 285.120,00 2452 GR‐2009‐1607755 PHOSPHOPROTEOMIC PROFILING OF COLORECTAL CANCER LIVER METASTASIS FOR RESPONSE PREDICTION AND TREATMENT IMPROVEMENT 25 biomedica Oncology 2 ‐ Translational Clinical € 223.000,00 2453 GR‐2009‐1604751 Congenital abnormalities of kidney and urinary tract: clinical and genetic study aimed to identify a proper work‐up for paediatric patients 25 biomedica Digestive, Kidney and Urological Systems € 196.000,00 2454 GR‐2009‐1475939 Innovative biomarkers in rheumatoid arthritis: cardiovascular risk scoring tools to promote a better management of cardiovascular disease in RA 25 biomedica Vascular and Hematology € 410.000,00 € 420.210,00 Pagina 216 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2455 RF‐2009‐1472659 Detection and characterization of Coxiella burnetii in water buffalo (Bubalus bubalis) 25 clinico assistenziale Veterinary ‐ Animal Health ‐ ANHE 2456 RF‐2009‐1475019 Monoclonal antibodies to external domains of the chemokine receptors CXCR4 and CCR5 to study structure and biology of the receptors during a mucosal inflammatory status 25 biomedica Immunology € 600.000,00 2457 RF‐2009‐1469081 Identification of molecular targets shared by apoptosis and EMT pathways in cancer 25 biomedica Oncology 1 ‐ Basic Translational € 455.000,00 2458 RF‐2009‐1474829 GENDER AND AGE‐RELATED DIFFERENCES IN HUMAN COLONIC SMOOTH MUSCLE: ROLE OF ESTROGENS 25 biomedica Digestive, Kidney and Urological Systems € 395.719,00 2459 RF‐2009‐1468328 Non invasive brain stimulation: a new therapeutic window in neurorehabilitation 25 biomedica Brain Disorders and Clinical Neuroscience € 522.500,00 2460 RF‐2009‐1529055 Prostate and breast cancer progression: biochemical studies for future clinical application of cholesterol modulators 25,17 biomedica Oncology 1 ‐ Basic Translational € 353.000,00 2461 GR‐2009‐1554074 PROGNOSTIC REGISTRY OF CT CORONARY ANGIOGRAPHY IN SUSPECTED CORONARY ARTERY DISEASE ‐ RECORD 25,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 250.000,00 2462 GR‐2009‐1607752 RETRACT: REducing TRAnsition to psychosis by Omega‐3 fatty acids ComplemenTation 25,25 clinico assistenziale Biobehavioral and Behavioral Processes € 550.000,00 2463 RF‐2009‐1549400 Integrated analytical platform for evaluating the effects of exposure to 1950 MHz UMTS signal by means of proteomics and metabolomics studies 25,25 biomedica Biological Chemistry and Macromolecular Biophysics € 599.610,00 2464 GR‐2009‐1578741 Vascular and inflammatory markers as new predictors of Silent Coronary Artery Disease in Postmenopausal Women 25,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 400.000,00 2465 GR‐2009‐1474613 A bioinformatic platform for the Systems Biology oriented analysis of variations in tumor genomes. 25,25 biomedica Genes, Genomes and Genetics € 400.000,00 2466 GR‐2009‐1607835 ROLE OF ORAI‐1 AND STIM‐1 UNDERLYING STORE‐OPERATED Ca2+ CURRENTS (SOCs) IN STROKE PATHOGENESIS 25,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 237.000,00 € 591.500,00 Pagina 217 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2467 GR‐2009‐1577405 GUILLAIN‐BARRÉ SYNDROME AND ITS VARIANTS: INVESTIGATION ON BIOMARKERS FOR PATHOGENESIS AND CLINICAL PRACTICE 25,5 biomedica Brain Disorders and Clinical Neuroscience € 181.060,00 2468 GR‐2009‐1578517 Non‐coding elements that regulate MeCP2 expression 25,5 biomedica Genes, Genomes and Genetics € 261.000,00 2469 RF‐2009‐1549257 Study on contamination patterns and source identification of foodborne zoonoses and toxic organic compounds and implementation of a surveillance network for reducing the exposure of resident population in Molise region 25,5 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 2470 GR‐2009‐1608664 EXOSOMES AND TUMOR RELATED VIRUSES. 25,5 biomedica Oncology 1 ‐ Basic Translational € 300.000,00 2471 GR‐2009‐1552067 Understanding the role of TRIM8, a novel p53 target gene, in the physiopatology of gliomas 25,5 biomedica Oncology 1 ‐ Basic Translational € 404.000,00 2472 RF‐2009‐1536082 PREDICTION OF POSTOPERATIVE RESPIRATORY FUNCTION WITH VOLUMETRIC AND DENSITOMETRIC COMPUTED TOMOGRAPHY AND VIBRATION RESPONSE IMAGING IN PATIENTS SUBMITTED TO LOBECTOMY FOR LUNG CANCER 25,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 150.000,00 2473 RF‐2009‐1537806 OPTIMAL HUMAN OVARIAN TISSUE CRYOPRESERVATION: SLOW FREEZING VERSUS VITRIFICATION 25,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 330.000,00 2474 GR‐2009‐1583894 Use of Coagulation Factors Concentrate for prevention of clinically significant postoperative bleeding in cardiac surgery 25,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 165.000,00 2475 GR‐2009‐1608282 Early diagnosis of Mild Cognitive Impairment: a new approach involving genetics, epigenetics and neuroimaging . 25,5 biomedica Genes, Genomes and Genetics € 280.000,00 2476 GR‐2009‐1606858 Multi‐level factors subserving healthy decision‐making as a reference for the understanding of decisional impairments in healthy aging, pathological‐gambling, addiction and Parkinsons disease. An integrated cognitive, personality, neurological and geneti 25,5 biomedica Biobehavioral and Behavioral Processes € 585.000,00 Pagina 218 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2477 RF‐2009‐1474149 Effect of cholera toxin B subunit on the cross talk between intestinal epithelial cells and dendritic cells 25,5 biomedica Immunology € 294.000,00 2478 RF‐2009‐1470170 INNOVATIVE MODEL TO MEET THE SOCIOCULTURAL NEEDS OF ADULT FOREIGN LANGUAGE SPEAKING CANCER PATIENTS IN THEIR DIAGNOSTIC AND THERAPEUTIC PROCEDURES 25,5 clinico assistenziale Healthcare Delivery and Methodologies € 450.000,00 2479 RF‐2009‐1476042 Cell therapy in veterinary medicine: identification of specific markers for animal Multipotent Stromal Cell (MSC) technologies 25,5 biomedica Veterinary ‐ Animal Health ‐ ANHE € 487.000,00 2480 GR‐2009‐1607291 TERAHERTZ SPECTROSCOPY AND IMAGING FOR DIAGNOSTIC PURPOSES IN REHABILITATION 25,67 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 600.000,00 2481 RF‐2009‐1527469 Oxidative Stress in the pathogenesis of neurodegenerative diseases: glutathione as a new key regulator of neurodegeneration in Friedreich's Ataxia 25,67 biomedica Molecular, Cellular, and Developmental Neuroscience € 415.800,00 2482 GR‐2009‐1596172 Identification of cancer stem cells in head and neck squamous cell carcinoma: a new model of cancerogenesis 25,67 biomedica Oncology 1 ‐ Basic Translational 2483 GR‐2009‐1596198 Self‐Configuring Communication Device for Stable and Reliable Tele‐Medicine Applications 25,75 biomedica Healthcare Delivery and Methodologies € 195.000,00 2484 GR‐2009‐1580221 Longitudinal cognitive assessment and communication in amyotrophic lateral sclerosis: eye‐tracking technology and the use of augmentative and alternative communication strategies 25,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 293.000,00 2485 GR‐2009‐1591572 Proposal for a Research Project on the assessment of the mechanical properties of the skin tumors. A three years project merging the researchers and technologies between IEO European Institute of Oncology and POLIMI. 25,75 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 273.300,00 2486 RF‐2009‐1505434 DNA damage and epigenetic mechanisms in chronic hepatitis C and hepatocellular carcinoma patients 25,84 biomedica Oncology 1 ‐ Basic Translational € 522.500,00 2487 RF‐2009‐1519538 Na+‐Ca2+ exchanger as new therapeutical target in management of bacteria‐ induced heart hypertrophy and related complications 26 biomedica Cardiovascular and Respiratory Sciences € 575.000,00 € 600.000,00 Pagina 219 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2488 GR‐2009‐1605788 New protein misfolding specificities in Alzheimer's disease and innovative recombinant antibody‐based approaches for diagnostics, imaging and therapeutics 26 biomedica Molecular, Cellular, and Developmental Neuroscience € 498.055,00 2489 RF‐2009‐1519532 The assessment of cancer risk behaviours of immigrant populations in Italy and the impact on the welcome context. Strategies for a conscious prevention. 26 clinico assistenziale Risk, Prevention and Health Behavior € 277.500,00 2490 GR‐2009‐1591201 Tumor cell death and new emerging drugs in sarcomas 26 biomedica Oncology 1 ‐ Basic Translational € 225.500,00 2491 GR‐2009‐1605258 Rare Disease Infant botulism: improvement of diagnostic method, microbiology of agents, clinical management and treatment 26 biomedica Infectious Diseases and Microbiology € 455.100,00 2492 GR‐2009‐1580268 Maintaining and Retraining Brain Organization Following Limb Immobilization 26 clinico assistenziale Integrative, Functional, and Cognitive Neuroscience € 176.000,00 2493 GR‐2009‐1580407 NEUROIMAGING AND NEUROPSYCHOLOGICAL ENDOPHENOTYPES OF EATING DISORDERS: GENETIC AND ENVIRONMENTAL RISK FACTORS 26 clinico assistenziale Brain Disorders and Clinical Neuroscience € 585.000,00 2494 RF‐2009‐1528899 ZINC THERAPY: SAFETY AND EFFICACY IN ALZHEIMERS DISEASE PATIENTS 26 clinico assistenziale Brain Disorders and Clinical Neuroscience € 600.000,00 2495 RF‐2009‐1523196 CHARACTERIZATION OF LEUKEMIC STEM CELLS IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA 26 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 2496 GR‐2009‐1592203 ANALYSIS OF ONCOGENETIC MECHANISMS OF HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CANCER (HLRCC) 26 clinico assistenziale Genes, Genomes and Genetics 2497 GR‐2009‐1608772 Production of secretory granules with repeating substructure: a suitable mechanism for intracytoplasmic storage of peptides with relevant biological activities 26 biomedica Biological Chemistry and Macromolecular Biophysics € 230.100,00 2498 RF‐2009‐1531680 POST‐HARVEST PRODUCTION TREATMENTS FOR THE CONTROL OF VIRAL CONTAMINATION IN BIVALVE MOLLUSKS: TOOLS FOR IMPROVEMENT OF SHELLFISH SAFETY 26 biomedica Veterinary ‐ Food Safety ‐ FOSA € 533.775,00 2499 GR‐2009‐1578852 Parathyroid Hormone and Endothelial Progenitor cells in Renal patients: Mobilization and Biological Characterization 26 clinico assistenziale Cardiovascular and Respiratory Sciences € 130.010,00 € 0,00 Pagina 220 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2500 GR‐2009‐1524463 Identification of novel mechanicistic and diagnostic markers of human heart failure: focus on oxidatively modified proteins 26 biomedica Cardiovascular and Respiratory Sciences € 525.000,00 2501 RF‐2009‐1509156 DEVELOPMENT OF MATCHED PROTOCOL TO ISOLATE, EXPAND AND MAXIMAZE CELL YIELD OF HUMAN ADIPOSE TISSUE DERIVED MSCs TO MEET NEEDS OF CELL THERAPY 26 biomedica Bioengineering Sciences and Technologies € 400.000,00 2502 RF‐2009‐1473745 OBESITY AND DIABETES/HYPERTENSION RISK IN CHILDREN: PREVENTION AND TREATMENT THROUGH MONITORED PHYSICAL ACTIVITY PROGRAMS 26 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 440.000,00 2503 RF‐2009‐1500737 Juvenile justice: development of a monitoring system to evaluate alcohol misuse in arrested teenagers 26 clinico assistenziale Risk, Prevention and Health Behavior € 588.500,00 2504 RF‐2009‐1485913 EVALUATION OF THE ESTROGENIC PROFILE OF DESMOID TUMORS AND ITS CORRELATION TO TUMORAL AGGRESSIVENESS AND ANTI‐ESTROGENIC THERAPY 26 biomedica Oncology 2 ‐ Translational Clinical € 250.000,00 2505 RF‐2009‐1494574 Malignant gliomas: tumor stem cells and phenotype and cell resistance. MDR and MGMT systems. 26 biomedica Oncology 1 ‐ Basic Translational € 522.000,00 2506 RF‐2009‐1474177 A new treatment of depression in the elderly: positive memory neurostimulation as an alternative to antidepressants? 26 clinico assistenziale Brain Disorders and Clinical Neuroscience € 75.000,00 2507 GR‐2009‐1483580 IDENTIFICATION OF NOVEL MOLECULAR TARGETS AND BIOLOGICAL AGENTS FOR THE CHEMOTHERAPY OF MALIGNANT PLEURAL MESOTHELIOMA 26 biomedica Oncology 2 ‐ Translational Clinical € 249.000,00 2508 RF‐2009‐1470023 Elucidation of the Mechanisms Responsible for the Enigmatic in vivo Iduronate‐2‐ Sulfatase (IDS) Mutant Transcript Correction to Wild‐Type in Hunter Syndrome 26 biomedica Genes, Genomes and Genetics € 474.481,00 2509 RF‐2009‐1511073 Comprehensive Gene Expression Analysis of Airway Epithelial Cells on All Stages of Chronic Obstructive Pulmonary Disease. 26,17 biomedica Cardiovascular and Respiratory Sciences € 598.950,00 2510 RF‐2009‐1549635 Reverse translating oncologic cachexia features into innovative therapeutic approaches for lung, liver and pancreatic cancer 26,25 biomedica Oncology 2 ‐ Translational Clinical € 588.000,00 Pagina 221 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2511 GR‐2009‐1592045 IDENTIFICATION OF MARKERS OF GENETIC INSTABILITY LEADING TO RESISTANCE TO TYROSINE‐KINASE INHIBITOR THERAPY AND DISEASE PROGRESSION IN CHRONIC MYELOID LEUKEMIA 26,25 biomedica Oncology 2 ‐ Translational Clinical € 295.000,00 2512 RF‐2009‐1511924 Randomized controlled trial on the effects of exercise training on bone mineral density and bone fractures risk in elderly patients with heart failure 26,34 clinico assistenziale Biology of Development and Aging € 295.000,00 2513 RF‐2009‐1474740 Standardization and validation of biomolecular methods for the detection of HAV, HEV and NoV in bivalve molluscs; evaluation of their presence in Italian seas, through coordination of the authorized laboratories at national level. 26,34 biomedica Veterinary ‐ Food Safety ‐ FOSA € 600.000,00 2514 GR‐2009‐1608067 Anthracycline‐induced cardiotoxicity: a molecular and functional approach. 26,5 biomedica Cardiovascular and Respiratory Sciences € 527.000,00 2515 GR‐2009‐1606730 DIFFERENTIATION OF CANCER CELLS INDUCED BY EXTREMELY LOW FREQUENCY MAGNETIC FIELDS 26,5 biomedica Oncology 1 ‐ Basic Translational 2516 RF‐2009‐1539645 Safety patient and risk management in a Geriatric‐Rehabilitation Department 26,5 clinico assistenziale Risk, Prevention and Health Behavior 2517 GR‐2009‐1576770 Redox state of tumor microenvironment: effect on cancer cell anchorage, anoikis and acquisition of metastatic phenotype. 26,5 biomedica Oncology 1 ‐ Basic Translational € 400.000,00 2518 RF‐2009‐1525558 Clinical implication of amyloid beta (A‐beta) and its receptor, the RAGE (Receptor for Advanced Glycation End Product), in the pathogenesis of glaucomatous neurodegeneration and its involvement in cognitive impairment 26,5 biomedica Brain Disorders and Clinical Neuroscience € 300.000,00 2519 RF‐2009‐1538846 POST‐SURGICAL ADJUVANT THERAPY FOR STAGE III MELANOMA PATIENTS 26,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 200.000,00 2520 RF‐2009‐1543780 Safety of workers with implanted medical devices in MRI environment: criteria for occupational risk evaluation 26,5 biomedica Healthcare Delivery and Methodologies € 598.950,00 2521 RF‐2009‐1535092 COGNITIVE STIMULATION PROGRAM TO ANTAGONISE COGNITIVE DECLINE, TO IMPROVE BEHAVIORAL DISTURBANCES AND QUALITY OF LIFE, IN PRODROMAL AND MILD TO MODERATE STAGES OF ALZHEIMER'S DISEASE. 26,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 600.000,00 € 183.100,00 € 150.000,00 Pagina 222 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2522 GR‐2009‐1560015 Innate immune response to respiratory virus infection in asthmatic children 26,5 biomedica Immunology € 585.000,00 2523 RF‐2009‐1523349 Abnormal ALT levels are a surrogate marker of acute Cytomegalovirus (CMV) infection that could reduce the risk of CMV‐transfusion‐transmitted infection? 26,5 clinico assistenziale Infectious Diseases and Microbiology € 290.000,00 2524 GR‐2009‐1591614 Autophagy manipulation as a strategy for fighting neuropathic pain and facilitating regenerative processes 26,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 577.500,00 2525 GR‐2009‐1608346 Prospect study on the social care integrated management of the oncological subject, in patients older than 70, with the aim of elaborating a new organizational model for the integration between hospital and extra‐hospital assistance 26,5 clinico assistenziale Risk, Prevention and Health Behavior € 150.000,00 2526 RF‐2009‐1486032 Exposure to dioxin: cellular damages and biological implications. Effects on viral infection, differentiation processes and cell proliferation 26,5 biomedica Veterinary ‐ Animal Health ‐ ANHE € 596.000,00 2527 GR‐2009‐1473440 The manometric pattern can be the key for the treatment of esophageal achalasia 26,5 clinico assistenziale Digestive, Kidney and Urological Systems € 160.000,00 2528 RF‐2009‐1471383 Surveillance of the circulation of rotaviruses in the infantile population of Sicily and of the ecology of rotavirus infections in view of the introduction of a rotavirus vaccine. Implications for vaccine adoption and immunization policies. 26,5 biomedica Population Sciences and Epidemiology 2529 RF‐2009‐1491309 A Novel Therapeutic Strategy Targeting Photoreceptor Oxidative Damage in ABCR‐related Retinal Degenerations: An Experimental and Clinical Study. 26,5 biomedica Brain Disorders and Clinical Neuroscience 2530 RF‐2009‐1530439 Traffic‐related air pollution near main roads and risk of respiratory tract cancers in the North‐East of Italy 26,67 biomedica Population Sciences and Epidemiology 2531 RF‐2009‐1491055 Survival of Lactic Acid Bacteria (LAB) able to produce biogenic amine (BA) in the human gastrointestinal tract 26,67 biomedica Veterinary ‐ Food Safety ‐ FOSA € 360.000,00 2532 GR‐2009‐1526436 Sleep‐Wake cycle and outcome of the Vegetative Patients and Minimal Responders 26,75 clinico assistenziale Brain Disorders and Clinical Neuroscience € 423.550,00 2533 GR‐2009‐1605245 Evaluation and validation of new bladder cancer markers through a new phosphoproteomic approach 26,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 175.000,00 € 191.500,00 € 299.200,00 € 111.100,00 Pagina 223 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2534 GR‐2009‐1567330 CAROTID ATHEROSCLEROSIS: MARKERS OF PROGRESSION AND INFLUENCE ON COGNITIVE IMPAIRMENT OCCURRENCE 26,75 biomedica Brain Disorders and Clinical Neuroscience € 280.000,00 2535 RF‐2009‐1548137 Clinical trial for the assessment of the safety and efficacy of autologous mesenchymal stem cell transplantation in parkinsonism 26,75 biomedica Brain Disorders and Clinical Neuroscience € 548.000,00 2536 RF‐2009‐1499201 Comparative evaluation of the diagnostic and prognostic role of serum and urinary PCA3, of advanced imaging techniques and of tissue and circulating molecular markers in prostate cancer patients. 26,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 541.500,00 2537 GR‐2009‐1591166 Biological dosimetry of Magnetic Resonance procedures in patients and occupational workers 26,84 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 330.000,00 2538 RF‐2009‐1529272 Reproductive and hormonal gonadal function assessment in type 1 and type 2 diabetic patients 26,84 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 155.000,00 2539 RF‐2009‐1537997 Functional Analysis of Homeobox Genes and microRNAs Expression Profiles in Mesenchymal Stem Cells. Application to Bone Tissue Engineering. 27 biomedica Biology of Development and Aging € 160.000,00 2540 GR‐2009‐1576814 Robotic and Mental Practice training effects: functional brain reorganization in walking recovery 27 clinico assistenziale Brain Disorders and Clinical Neuroscience € 540.000,00 2541 RF‐2009‐1523696 SETUP AND APPLICATION OF INNOVATING MODELS BASED ON BIOTECHNOLOGICAL METHODS FOR THE CONTROL AND MANAGEMENT OF VIRUS, PARASITE AND MICROCONTAMINANT FOOD RISKS 27 biomedica Veterinary ‐ Food Safety ‐ FOSA € 593.500,00 2542 GR‐2009‐1584458 Specific absorption of putative pathogenetic anti‐domain I of beta2‐glyoprotein I (aDmI/beta2GPI) antibodies in high risk patients with Antiphosphiolipid Syndrome (APS) 27 biomedica Vascular and Hematology € 165.000,00 2543 RF‐2009‐1535237 Management of manpower health and productivity in an Infectious Dieseases Dept 27 clinico assistenziale Risk, Prevention and Health Behavior 2544 RF‐2009‐1550454 Novel diagnostic and treatment strategies for sepsis in critically ill patients 27 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 113.250,00 € 510.000,00 Pagina 224 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2545 GR‐2009‐1605438 HISTOLOGICAL DATA FROM ATRIAL BIOPSY COUPLED TO TRANSSEPTAL PUNCTURE IN ATRIAL FIBRILLATION PATIENTS 27 clinico assistenziale Cardiovascular and Respiratory Sciences 2546 GR‐2009‐1607881 COCAINE ADDICTION AND CARDIOVASCULAR DAMAGE: an in vivo model combined with an in vitro model to evaluate the possible role of oxidative stress in accelerated atherosclerosis and left ventricular hypertrophy. 27 clinico assistenziale Risk, Prevention and Health Behavior 2547 GR‐2009‐1594587 Involvement of the atypical cytokine and chemokine receptors Tir8 and D6 in the pathogenesis of Inflammatory Bowel Disease 27 biomedica Immunology € 320.000,00 2548 GR‐2009‐1579626 Studies of the pathogenic mechanisms of Porcine Circovirus type 2 (PCV2) and Torque Teno virus (TTV) that can be transmitted from animals to human 27 biomedica Veterinary ‐ Animal Health ‐ ANHE € 425.700,00 2549 GR‐2009‐1555924 SENTINEL NODE IDENTIFICATION WITH SENTINELLA INTRAOPERATIVE GAMMACAMERA vs TRADITIONAL GAMMAPROBE: IS THERE AN IMPROVEMENT IN ACCURACY? 27 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 250.000,00 2550 GR‐2009‐1595858 Evaluation of the frequency of putative cancer stem cells in paired primary and metastastic tissue in breast cancer patients. 27 biomedica Oncology 1 ‐ Basic Translational € 255.000,00 2551 RF‐2009‐1511861 DIETARY USE OF GOAT MILK AND DAIRY PRODUCTS IN THE PREVENTION OF SKELETAL SYSTEM DEGENERATIVE DISEASES, WITH PARTICULAR REGARD TO PATIENTS IN NEUROREHABILITATION: NUTRITIONAL AND HYGIENIC ASSESSMENT. 27 biomedica Veterinary ‐ Food Safety ‐ FOSA € 565.000,00 2552 RF‐2009‐1505469 Venous Thromboembolism (VTE) risk in patients with cancer undergoing surgery and anesthesia 27 clinico assistenziale Vascular and Hematology € 200.000,00 2553 GR‐2009‐1600157 Clinical, pharmacological and biochemical correlation between epilepsy and depression. Identification of common therapeutical approaches. 27 biomedica Brain Disorders and Clinical Neuroscience € 420.000,00 2554 RF‐2009‐1531437 WHOLE GENOME GENE EXPRESSION PROFILING OF CIRCULATING TUMOR CELLS (CTCs), METASTATIC AXILLARY NODES AND PRIMARY TUMORS BY SINGLE‐CELL INTERROGATION METHODOLOGY IN PATIENTS WITH LOCALLY ADVANCED BREAST CANCER 27 biomedica Oncology 2 ‐ Translational Clinical € 217.800,00 € 559.800,00 € 151.292,00 Pagina 225 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2555 GR‐2009‐1578374 Introducing translational clinical endpoints in longevity studies of laboratory mice: development of mice models of frailty or robustness from metallothionein transgenic mice 27 biomedica Biology of Development and Aging 2556 GR‐2009‐1601008 In vitro studies on the effects of CFTR mutations on RNA expression and protein function 27 biomedica Genes, Genomes and Genetics € 145.000,00 2557 GR‐2009‐1576325 Molecular characterization and role of RCAN3 (Regulator of calcineurin family member 3) in cardiac development and function 27 biomedica Cardiovascular and Respiratory Sciences € 203.250,00 2558 GR‐2009‐1580306 Beta‐catenin mutation in desmoid tumor: impact on prognosis and response to commonly‐used drugs 27 clinico assistenziale Oncology 2 ‐ Translational Clinical € 458.700,00 2559 RF‐2009‐1474271 Analysis of biological processes during wound healing: clinical and forensic applications 27 biomedica Cell Biology € 169.000,00 2560 RF‐2009‐1505076 Predictivity for MPN of screening for JAK2 V617F ad TET2 mutations in asymptomatic patients with splanchnic thrombosis and usefulness in clinical management and counselling. 27 clinico assistenziale Vascular and Hematology € 190.000,00 2561 RF‐2009‐1473453 Searching into possible molecular and genetic relationships among the metabolic syndrome, cardiovascular disease and longevity: novel proposed markers of aging and premature atherosclerosis. 27,17 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 408.000,00 2562 RF‐2009‐1529124 Systematic active research and epidemiological analysis of occupational cancer cases 27,25 biomedica Population Sciences and Epidemiology € 600.000,00 2563 RF‐2009‐1511163 ROLE OF ANASTHESIA ON IMMUNE RESPONSE 27,25 clinico assistenziale Immunology € 200.000,00 2564 RF‐2009‐1498562 MULTIDISCIPLINARY CARE CENTER FOR PREGNANT AND POST‐PARTUM WOMEN 27,25 clinico assistenziale Risk, Prevention and Health Behavior € 400.000,00 2565 RF‐2009‐1483428 Investigating early cognition by electrophysiology and genomics: a study of infant twins 27,25 biomedica Biobehavioral and Behavioral Processes € 337.000,00 2566 GR‐2009‐1604116 Unawareness of Disease, Functional Recovery, Treatment Compliance and Rehabilitation Outcome: a Multidimensional Approach 27,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 540.000,00 € 598.400,00 Pagina 226 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2567 GR‐2009‐1608156 A possible use of membrane vesicles in medicine 27,5 biomedica Cell Biology € 550.000,00 2568 RF‐2009‐1545072 Human whole genome expression profiles in tissues and in the peripheral blood mononuclear cell (PBMC) of patients with ruptured and unruptured aneurysms for the identification of novel predictive genetic biomarkers. 27,5 biomedica Genes, Genomes and Genetics € 222.000,00 2569 RF‐2009‐1536186 MicroRNAs expression profile and modulation in nonsmall cell lung cancer progression. 27,5 biomedica Oncology 2 ‐ Translational Clinical € 452.050,00 2570 GR‐2009‐1560012 Anticancer treatment‐induced cardiovascular diseases involve alterations in resident cardiac and circulating progenitor cells and is gender dependent: new targets for the prevention and therapy of cardiotoxicity. 27,5 biomedica Oncology 2 ‐ Translational Clinical € 597.250,00 2571 RF‐2009‐1536422 RESTRICTIVE TRANSFUSION POLICY IN CARDIAC SURGERY: FINDING THE CLINICALLY ACCEPTABLE LIMIT OF POSTOPERATIVE ANEMIA 27,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 150.000,00 2572 RF‐2009‐1524169 Reduction of amyloid‐beta load in Alzheimers disease by Toll‐like Receptor activity modulation with low and high molecular weight Hyaluronan : in vitro and in vivo studies for a new therapeutic approach to the disease. 27,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 150.000,00 2573 GR‐2009‐1606790 Use of magnetic resonance venography as a validation tool of the relationship between chronic cerebrospinal venous insufficency and multiple sclerosis 27,5 clinico assistenziale Integrative, Functional, and Cognitive Neuroscience € 203.800,00 2574 GR‐2009‐1608472 BIOMOLECULAR CHARACTERIZATION OF MELANOMA ARISED FROM PRE‐ EXISTENT NEVUS IDENTIFIED USING DERMOSCOPIC APPROACH 27,5 biomedica Oncology 2 ‐ Translational Clinical € 590.000,00 2575 GR‐2009‐1604877 Incidental Thyroid Nodules in Melanoma patients: evaluation of their malignancy and correlated hormonal abnormalities. Detection of RET tyrosine kinase receptor (RET/PTC) rearrangements and BRAF mutation in thyroid cells in patients with concomitant me 27,5 clinico assistenziale Oncology 1 ‐ Basic Translational € 190.000,00 2576 RF‐2009‐1474608 Altered Vessel Signaling And Impaired Recruitment of Endothelial Progenitor Cells as a Mechanisms Underlying the Chronic Ischemic Complications of Diabetes. 27,5 biomedica Vascular and Hematology € 479.150,00 2577 GR‐2009‐1473348 Physical rehabilitation in a neurological unit: Burnout and coping strategies 27,5 clinico assistenziale Risk, Prevention and Health Behavior € 274.000,00 Pagina 227 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto clinico assistenziale Brain Disorders and Clinical Neuroscience € 312.400,00 27,75 biomedica AIDS and Related Research € 305.000,00 Extravasation project: prevention, treatment and monitoring 27,75 clinico assistenziale Oncology 2 ‐ Translational Clinical € 185.000,00 2581 GR‐2009‐1578843 Endocrinological and metabolical effects of bariatric surgery 28 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 155.000,00 2582 RF‐2009‐1546513 Bladder wall investigation in patients affected by bladder outlet obstruction 28 clinico assistenziale Digestive, Kidney and Urological Systems € 176.500,00 2583 GR‐2009‐1576812 Optimization of the use of Topotecan as anti‐hypoxia drug 28 biomedica Oncology 2 ‐ Translational Clinical € 500.000,00 2584 GR‐2009‐1607550 NT‐UF‐study: NT‐proBNP driven volume unloading in decompensated heart failure: ultrafiltration versus intravenous diuretics. Neurohormonal effects and prognosis. 28 clinico assistenziale Cardiovascular and Respiratory Sciences € 216.620,00 2585 GR‐2009‐1607929 Investigation of Immune Function in Individuals with Different Status of Alpha‐1 Antitrypsin Deficiency 28 biomedica Cardiovascular and Respiratory Sciences € 200.000,00 2586 GR‐2009‐1599852 Notch1 and N‐cadherin expression as possible novel prognostic markers in cutaneous melanoma 28 biomedica Oncology 1 ‐ Basic Translational 2587 GR‐2009‐1606900 In vivo evaluation of the effects caused by plant extracts and their components on the proliferation and differentiation of adult stem cells in a simple animal model for potential applications in the field of regenerative medicine 28 biomedica Cell Biology 2588 GR‐2009‐1607192 Internal Loop Recorder Device to detect atrial fibrillation in patients with cryptogenic ischemic stroke: a randomised controlled trial 28 clinico assistenziale Cardiovascular and Respiratory Sciences 2578 RF‐2009‐1474105 Mirror therapy rehabilitation after child brain tumor hemiparesis 27,5 2579 GR‐2009‐1580237 The HIV‐1 pathogenicity factor Nef as a novel therapeutic target in opportunistic infections. 2580 RF‐2009‐1499049 € 182.692,00 € 580.000,00 € 371.000,00 Pagina 228 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2589 GR‐2009‐1601815 SUBCLINICAL MYOPATHY IN COLORECTAL CANCER AT THE CLINICAL ONSET OF THE DISEASE: DIAGNOSTIC AND PROGNOSTIC ROLE OF HUMORAL BIOMARKERS OF MUSCLE DAMAGE AND REGENERATION 28 biomedica Oncology 1 ‐ Basic Translational € 150.000,00 2590 GR‐2009‐1606848 OXIDATIVE STRESS‐MEDIATED NEURONAL DAMAGE IN NEURODEGENERATIVE DISORDERS: NEW POTENTIAL THERAPEUTIC APPROACHES FOR FRIEDREICHS ATAXIA 28 biomedica Brain Disorders and Clinical Neuroscience € 388.300,00 2591 RF‐2009‐1547118 Pressure ulcers and microbial biofilms: development of novel drug‐releasing dressings for their prevention and treatment 28 biomedica Infectious Diseases and Microbiology € 600.000,00 2592 GR‐2009‐1594649 Characterization of prostate cancer stem cells for the identification of new prognostic markers and/or targets for novel anticancer therapies. 28 biomedica Oncology 2 ‐ Translational Clinical € 360.000,00 2593 GR‐2009‐1591514 Plasmatic oxidative stress markers in Sicilian people living in industrial areas 28 biomedica Risk, Prevention and Health Behavior € 302.700,00 2594 GR‐2009‐1606643 New therapeutic perspectives in the treatment of infantile hemangiomas in rapid proliferative phase: use of propranolol and evaluation of molecular markers involved in its mechanism of action. 28 biomedica Vascular and Hematology € 485.000,00 2595 GR‐2009‐1579952 Parents‐adolescents relationships: the key of successful prevention in adolescence 28 clinico assistenziale Risk, Prevention and Health Behavior € 305.550,00 2596 GR‐2009‐1607309 Mucosal cytokine levels in colorectal cancer 28 clinico assistenziale Oncology 2 ‐ Translational Clinical € 150.000,00 2597 GR‐2009‐1606432 TOURETTE SYNDROME IN CHILDHOOD AND ASOLESCENCE: VALIDATION AND CLINICAL‐PHARMACOLOGICAL APPLICATION OF A QUALITY‐OF‐LIFE SCALE 28 clinico assistenziale Biobehavioral and Behavioral Processes € 193.000,00 2598 GR‐2009‐1574778 Pathways controlling ErbB2 mediated cardiac protection: mitochondrial function and calcium cycling during oxidative stress. 28 biomedica Cardiovascular and Respiratory Sciences € 350.000,00 2599 RF‐2009‐1530983 Traditional and organic foods comparison in patients with different degrees of obesity versus healthy subjects: analysis of foods and their chemical/physical evaluation. 28 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 475.000,00 Pagina 229 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2600 RF‐2009‐1543822 A novel class of molecules against Gram‐negative bacteria 28 biomedica Infectious Diseases and Microbiology € 500.000,00 2601 RF‐2009‐1469588 A novel therapeutic strategy against breast cancer: cAMP elevating drugs and leptin 28 biomedica Oncology 1 ‐ Basic Translational € 240.000,00 2602 RF‐2009‐1536132 Early diagnosis and K‐Ras, PT53, APC and BRAF mutations in colorectal cancer 28,25 biomedica Genes, Genomes and Genetics € 185.000,00 2603 GR‐2009‐1575111 CAlabRian Epidemiological observatory on early stages of KIDney dysfunction and cardiovascular risk factors at pediatric age ‐ The CAREKID‐CV project 28,25 clinico assistenziale Population Sciences and Epidemiology € 600.000,00 2604 GR‐2009‐1575635 MESENCHYMAL STEM CELL TRANSPLANTATION IN NEUROPATHIC PAIN TREATMENT 28,25 biomedica Molecular, Cellular, and Developmental Neuroscience € 305.000,00 2605 RF‐2009‐1549441 On the road to growth ‐ Empowering mental health in adolescents, with particular focus on preventing or reducing drug use 28,25 clinico assistenziale Risk, Prevention and Health Behavior € 200.000,00 2606 RF‐2009‐1548655 In vivo, non invasive, quantification of ß‐cell mass loss during diabetes progression by means of Diffusion Weighted Magnetic Resonance Imaging (DWI‐ MRI) and Manganese Enhanced MRI (ME‐MRI), performed on mouse model diabetes type 2 and human Impaired Gluc 28,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 434.000,00 2607 RF‐2009‐1521695 A study investigating the presence of prion infectivity in Sardinian ovine cheese 28,34 biomedica Veterinary ‐ Food Safety ‐ FOSA € 400.000,00 2608 GR‐2009‐1608026 Effects of pharmacological and natural compounds on putative biomarkers of prostate‐related diseases: integration of novel endpoints derived by system biology approaches. (ANDROS) 28,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 600.000,00 2609 GR‐2009‐1605750 DEVELOPMENT OF EVIDENCE BASED GUIDELINES TO TREAT CARPAL TUNNEL SYNDROME AND ULNAR NERVE AT ELBOW 28,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 229.600,00 2610 GR‐2009‐1606714 GENetically determined Endothelial Dysfunction and Insulin Resistance (GENEDIR): an experimental and translational study on the molecular mechanisms linking endothelial dysfunction, insulin signalling and cardiovascular damage 28,5 biomedica Cardiovascular and Respiratory Sciences € 599.250,00 Pagina 230 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2611 GR‐2009‐1594629 New methodologies for monitoring of Vibrio spp. in crustaceans and for evaluation of their potential pathogenicity 28,5 biomedica Infectious Diseases and Microbiology 2612 GR‐2009‐1504156 Microenvironment modifications in cancer induced by chronic stress 28,5 biomedica Biobehavioral and Behavioral Processes 2613 GR‐2009‐1591847 Co‐occurrence of asymptomatic brain lesions, inter‐atrial septal abnormalities and cerebrovascular risk factors in the young population of Verona. 28,75 clinico assistenziale Brain Disorders and Clinical Neuroscience 2614 GR‐2009‐1579315 AN INNOVATIVE TRANSDERMAL DRUG DELIVERY DEVICE FOR THE TREATMENT OF TYPE 1 DIABETES 29 biomedica Bioengineering Sciences and Technologies € 371.000,00 2615 GR‐2009‐1608004 Optimizing of DNA vaccination with synapsin in the suppression of experimental autoimmune encephalomyelitis 29 biomedica Immunology € 242.857,00 2616 GR‐2009‐1595378 Post mortem adult neural stem cell transplantation on traumatic spinal cord injury and neurodegenerative diseases 29 biomedica Molecular, Cellular, and Developmental Neuroscience € 597.000,00 2617 RF‐2009‐1511533 Exercise cardiac Output Change in Ventricular Reconstruction for heart failure due to Ischemic Cardiomyopathy 29 clinico assistenziale Cardiovascular and Respiratory Sciences € 183.500,00 2618 RF‐2009‐1535266 Prospective study on movement perception and performance in early autism: clinical predictors and neural correlates 29 clinico assistenziale Brain Disorders and Clinical Neuroscience € 555.000,00 2619 RF‐2009‐1550952 Tandem treatment with 90Y and 177Lu‐labelled somatostatin analogues of patients with neuroendocrine tumours non responding to conventional therapy 29 clinico assistenziale Oncology 2 ‐ Translational Clinical € 513.700,00 2620 GR‐2009‐1607263 Aminoacid substitutions (AAS) rate of proteins encoded by mitochondrial DNA (mtDNA) in high grade glioma patients: a translational approach. 29 clinico assistenziale Emerging Technologies and Training in Neurosciences 2621 GR‐2009‐1607395 The Emilia Romagna First Episode Psychosis project: a contribution to the European Network of National Schizophrenia Networks Studying Gene‐ Environment Interactions 29 biomedica Biobehavioral and Behavioral Processes 2622 RF‐2009‐1549733 Comparative analysis of vitreal inflammatory and angiogenic factors in vitreoretinal disorders 29 biomedica Cell Biology € 300.000,00 € 0,00 € 600.000,00 € 600.000,00 € 156.000,00 € 600.000,00 Pagina 231 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2623 GR‐2009‐1530400 NON DESTRUCTIVE 3D ANALYSIS OF BONE‐IMPLANT INTERFACE WITH HIGH RESOLUTION MICRO‐CT SYSTEM: DEVELOPMENT OF 3D PARAMETERS FOR OSTEOINTEGRATION EVALUATION AND THEIR VALIDATION BY MEAN OF 2D HISTOMORPHOMETRY AND MECHANICAL TESTS 29 biomedica Musculoskeletal, Oral and Skin Sciences € 495.600,00 2624 RF‐2009‐1492698 SCAFFOLD INTERACTION WITH BONE MARROW‐DERIVED MESENCHYMAL STEM CELLS IN AN ONE‐STEP PROCEDURE FOR OSTEOCHONDRAL REPAIR 29 biomedica Musculoskeletal, Oral and Skin Sciences € 218.160,00 2625 RF‐2009‐1474113 Definition of new long term predictive biomarkers of TD2 and associated CVD, and identification of novel therapeutic targets. 29 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 580.000,00 2626 RF‐2009‐1471781 Genetic and biochemical markers for Huntington's disease. 29 biomedica Brain Disorders and Clinical Neuroscience € 480.000,00 2627 GR‐2009‐1486845 Multi‐layer analysis of adult human stromal cells from different origins: insights into cardiovascular differentiation 29 biomedica Cardiovascular and Respiratory Sciences € 440.000,00 2628 RF‐2009‐1488138 Development of algorithms for real‐time detection of neonatal seizures by analyzing video signals 29 biomedica Brain Disorders and Clinical Neuroscience € 356.800,00 2629 RF‐2009‐1475395 Beyond Adoption and Diffusion towards "Normalization". Integrating new technologies within health organizations and systems: a study of factors that promote or inhibit routine embedding of innovations using the Normalization Process Theory (AD‐NORMAL) 29 clinico assistenziale Healthcare Delivery and Methodologies € 569.000,00 2630 RF‐2009‐1549325 COMPLEMENTARY THERAPIES IN PARKINSONS DISEASE: A MULTIDIMENSIONAL APPROACH FOR A BETTER QUALITY OF LIFE. 29,17 clinico assistenziale Integrative, Functional, and Cognitive Neuroscience € 150.000,00 2631 GR‐2009‐1575662 Role of insulin in early pericyte loss: implications in the pathogenesis of diabetic retinopathy. 29,25 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 312.500,00 2632 RF‐2009‐1550144 MUTATIONAL ANALISYS OF GENES PKD1 E PKD2 IN SICILIAN POPULATION WITH POLICISTIC KIDNEY DISEASE 29,34 biomedica Genes, Genomes and Genetics € 319.000,00 Pagina 232 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2633 RF‐2009‐1539483 INNOVATIVE INTEGRATE CLINICAL PATHWAY TO IMPROVE THE OUTCOME OF PATIENTS AFFECTED WITH PANCREATIC CANCER 29,34 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 117.250,00 2634 RF‐2009‐1543730 An integrated approach to the optimization of dose and image quality for computed radiography and digital radiography 29,34 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 209.000,00 2635 RF‐2009‐1537530 Long‐term assessment of the immunological profile in patients with psoriasis/psoriatic arthritis treated with biologics targeting immune response mediators 29,5 clinico assistenziale Immunology € 400.000,00 2636 RF‐2009‐1538509 Clinical and psychological advantages of controlling pain in high risk surgical patients: Neurophysiological monitoring of the afferent and efferent pain pathway. 29,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering 2637 GR‐2009‐1608337 After traumatic brain injury: Evaluation of the procedures helping patients to return to drive and testing of a new rehabilitation protocol. 29,5 biomedica Risk, Prevention and Health Behavior € 600.000,00 2638 GR‐2009‐1608339 VIRAL MONITORING FOR PREVENTION OF SEVERE POST‐TRANSPLANT INFECTIONS AND VIRUS‐LINKED CANCER 29,5 clinico assistenziale Immunology € 205.000,00 2639 RF‐2009‐1550265 SPONTANEOUS MAST CELL TUMOURS IN DOG AS A MODEL FOR HUMAN TUMOURS EXPRESSING C‐KIT RECEPTOR: DEVELOPING A BIOBANK FOR TRANSLATIONAL ANGIOGENETIC STUDIES AND TARGETED THERAPYES 29,5 biomedica Oncology 1 ‐ Basic Translational € 250.000,00 2640 RF‐2009‐1550122 Autistic phenotype: a clue for the diagnosis of the idic(15) syndrome; a neurogenetic disorder characterized by autistic symptoms, intellectual disability, and epilepsy. Study of the neuro‐behavioral phentoptype, and molecular cytogenetics, with genotype‐ 29,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 438.000,00 2641 GR‐2009‐1578001 Role of functional CD4+T cells subsets in the collateral response to acute ischemia 29,5 biomedica Immunology € 519.150,00 2642 RF‐2009‐1504201 IFN‐alpha improves Vgamma9Vdelta2 T cell antiviral activity : implication for new combined therapeutic strategies in HCV infection 29,5 biomedica Immunology € 300.000,00 2643 RF‐2009‐1473824 Management of aggression in dogs: ethologic and laboratory parameters 29,5 biomedica Veterinary ‐ Animal welfare ‐ ANWE € 400.000,00 € 310.000,00 Pagina 233 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2644 GR‐2009‐1601095 Innovative tools for biological agents exposure assessment in workplaces 29,75 biomedica Infectious Diseases and Microbiology 2645 RF‐2009‐1526394 Evaluation of stalking phenomenon: victims, stalkers and professional 29,75 clinico assistenziale Risk, Prevention and Health Behavior 2646 GR‐2009‐1604755 NON‐ALCOHOLIC FATTY LIVER DISEASE (NAFLD), GENETIC POLYMORPHISMS, HORMONAL PROFILE AND LIPIDOMICS AS NEW RISK FACTORS FOR ATHEROSCLEROSIS: A STUDY IN THREE DIFFERENT VASCULAR DISTRICTS. 30 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences 2647 GR‐2009‐1576289 Emerging viral infections: diagnosis, pathogenesis and host immune response 30 biomedica Infectious Diseases and Microbiology € 540.000,00 2648 GR‐2009‐1606375 Potential interplay of cancer stem cells and NF‐kB inflammatory pathway in gastrointestinal adenocarcinoma: novel cancer approaches 30 biomedica Oncology 1 ‐ Basic Translational € 297.000,00 2649 GR‐2009‐1607253 A population‐based characterization of potential microbial etiologies of Crohn disease and Type 1 Diabetes Mellitus 30 biomedica Infectious Diseases and Microbiology € 600.000,00 2650 GR‐2009‐1607276 ESTROGEN RECEPTOR BETA EXPRESSION AND METHYLATION OF GENE‐ER AS A MOLECULAR PROGNOSTIC MARKER OF CANCER PROGRESSION IN ULCERATIVE COLITIS 30 biomedica Digestive, Kidney and Urological Systems € 99.000,00 2651 RF‐2009‐1539938 Late‐onset epilepsy: epidemiology, pathogenesis and predictive criteria of recurrence after a first unprovoked seizure 30 clinico assistenziale Molecular, Cellular, and Developmental Neuroscience € 510.000,00 2652 RF‐2009‐1550172 GENESIS, TRANSMISSION AND PROCESSING OF NEURAL INFORMATION IN NEURODEGENERATIVE DISEASES 30 clinico assistenziale Brain Disorders and Clinical Neuroscience € 255.000,00 2653 RF‐2009‐1509168 Molecular analysis of pathways involving p53 family members and non‐ clustered homeobox genes in mammary gland 30 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 2654 GR‐2009‐1568908 Isolated ruminant mammary stem cell population and uses thereof for production of transgenic proteins in vivo 30 biomedica Biology of Development and Aging 2655 GR‐2009‐1608769 Role of Notch 4 in rigeneration and neoangiogenesis of hepatocellular carcinoma. 30 biomedica Oncology 1 ‐ Basic Translational € 362.000,00 € 315.500,00 € 0,00 € 226.111,00 € 280.000,00 Pagina 234 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2656 GR‐2009‐1607260 ANALISYS OF SHORT TERM MORTALITY BASED ON REGISTRY FOR TYPE 1 DIABETES IN ITALY (RIDI) 30 clinico assistenziale Population Sciences and Epidemiology 2657 GR‐2009‐1596139 Direct assessment of ventricular‐arterial coupling in asymptomatic patients at risk of developing heart failure. Role of gender and age. 30 clinico assistenziale Cardiovascular and Respiratory Sciences € 252.000,00 2658 RF‐2009‐1473249 Dysregulation of Expression and Functionality of small non‐coding RNAs (miRNAs) in Breast Cancer and Intervention by Curcumin 30 biomedica Risk, Prevention and Health Behavior € 403.390,00 2659 RF‐2009‐1504250 Development and clinical applications of natural foods with antiinflammatory properties 30 biomedica Cardiovascular and Respiratory Sciences € 309.720,00 2660 RF‐2009‐1504736 IN VITRO AND IN VIVO IDENTIFICATION OF NOVEL MORPHO‐ BIOCHEMICAL MARKERS OF LIVER FIBROSIS AND THEIR TRANSLATION INTO CLINICAL PRACTICE 30 biomedica Digestive, Kidney and Urological Systems € 600.000,00 2661 GR‐2009‐1600153 New approach for in‐vitro study of fixture‐abutment connections to avoid implant failure 30,17 biomedica Bioengineering Sciences and Technologies 2662 GR‐2009‐1474551 Three dimensional dosimetry for radiotherapy by means of optically detected Fricke gel 30,25 biomedica Oncology 2 ‐ Translational Clinical € 600.000,00 2663 RF‐2009‐1550248 Percutaneous injection of bone substitute in hips of the severe osteoporotic patients to prevent fractures 30,34 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 140.000,00 2664 GR‐2009‐1580501 Genetic and molecular physiopathology of Intrahepatic Cholestasis of Pregnancy: possible correlations with the development of fetal complications 30,34 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 137.000,00 2665 GR‐2009‐1608065 Development of innovative instruments for the characterization and evaluation of high frequency percussive ventilation systems 30,5 biomedica Bioengineering Sciences and Technologies 2666 GR‐2009‐1591891 <<Hybrid>> revascularisation by combined CABG and PCI in multivessel coronary disease. A randomized comparison with conventional coronary by‐pass surgery 30,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 75.000,00 € 511.000,00 € 221.112,50 € 565.000,00 Pagina 235 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2667 GR‐2009‐1604786 A fMRI STUDY ON BRAIN FUNCTIONAL CHANGES AND NEUROPLASTICITY IN INFLAMMATORY DISORDERS 30,5 biomedica Digestive, Kidney and Urological Systems 2668 RF‐2009‐1499094 Effectiveness of Selective Intercostal Neurectomy for Chronic Pain following Breast Surgery 30,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 410.000,00 2669 RF‐2009‐1549688 Assessment of kinetic of selected priority contaminants in three species of aquacultured bivalves and study of relationships to farming environment ‐ project BIVA‐CONT 30,67 biomedica Veterinary ‐ Food Safety ‐ FOSA € 470.000,00 2670 GR‐2009‐1604854 Role of estrogen receptor in the uptake of recombinant MnSOD in tumor cells 30,84 biomedica Oncology 1 ‐ Basic Translational € 460.000,00 2671 GR‐2009‐1574289 A multifunctional approach: from animal welfare through product quality to reach consumer health in poultry meat chains 31 biomedica Veterinary ‐ Food Safety ‐ FOSA 2672 GR‐2009‐1600973 Role of microRNAs in human glioblastoma 31 biomedica Oncology 1 ‐ Basic Translational € 416.000,00 2673 RF‐2009‐1539635 A Gene array study of early tight junction alterations in the neoterminal ileum after curative resection in Crohns disease. 31 clinico assistenziale Digestive, Kidney and Urological Systems € 175.000,00 2674 RF‐2009‐1532179 Monitoring of heavy metals and nanoparticles in fishes and baby foods of animal origin 31 biomedica Veterinary ‐ Food Safety ‐ FOSA € 457.000,00 2675 RF‐2009‐1547373 INTEGRATED MODEL OF NOSOCOMIAL MICROBIOLOGIC MONITORING AND EPIDEMIOLOGICAL SURVEILLANCE. 31 clinico assistenziale Infectious Diseases and Microbiology € 320.000,00 2676 GR‐2009‐1555991 Re‐sequencing protocols, an high throughput molecular approach for diagnosis of clinically heterogeneous genetic disorders 31 biomedica Genes, Genomes and Genetics € 297.465,00 2677 RF‐2009‐1531057 Phase 2/3, twelve‐month, multicenter, intra‐subject controlled (retrospective‐ prospective), open‐label, active‐treatment study to evaluate the efficacy, safety, tolerability and pharmacokinetics of cinacalcet hydrochloride for the treatment of secondary h 31 clinico assistenziale Digestive, Kidney and Urological Systems € 403.488,00 € 9.000,00 € 210.100,00 Pagina 236 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2678 GR‐2009‐1607955 Molecular modeling of antibiotic efflux systems in Gram‐negative bacteria: unveiling the relations among energy transfer, proteins dynamics and extrusion of antibiotics 31 biomedica Biological Chemistry and Macromolecular Biophysics 2679 GR‐2009‐1539473 Design and synthesis of new molecules active against multidrug‐resistant bacteria. 31 biomedica Interdisciplinary Molecular Sciences and Training 2680 GR‐2009‐1591917 INHIBITION OF HDAC6 FUNCTIONS IN NOVEL THERAPEUTIC APPROACHES 31 biomedica Oncology 1 ‐ Basic Translational € 338.800,00 2681 GR‐2009‐1472374 BIOMARKERS RESEARCH FOR DIFFERENTIAL AND NONINVASIVE DIAGNOSIS OF CHRONIC ALLOGRAFT DYSFUNCTION IN KIDNEY TRANSPLANTATION 31 clinico assistenziale Digestive, Kidney and Urological Systems € 154.500,00 2682 RF‐2009‐1539621 PET/CT guidance for adaptive PTV tomotherapy re‐irradiations in local‐ relapse tumors or in‐field secondary tumors 31,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 600.000,00 2683 RF‐2009‐1551181 Project for a global therapeutic strategy of Transcatheter aortic valve implantation (TAVI) for isolated severe aortic stenosis in Veneto 31,25 clinico assistenziale Cardiovascular and Respiratory Sciences € 150.000,00 2684 GR‐2009‐1600422 ACE I and ACE II expression in normal and UVB‐induced damage conjunctiva cells and its relationship with the pterygium disease 31,25 biomedica Immunology € 180.984,60 2685 RF‐2009‐1483797 Inhaled anesthesia, cognitive decline progression and Alzheimers Disease acceleration in older subjects with Mild Cognitive Impairment 31,5 clinico assistenziale Brain Disorders and Clinical Neuroscience € 412.250,00 2686 RF‐2009‐1475233 An integrated functional and bioinformatic approach to identify deregulated EMT‐ associated pathways in the progression of epithelial ovarian and thyroid cancer and melanoma 31,67 biomedica Oncology 1 ‐ Basic Translational € 192.500,00 2687 GR‐2009‐1580267 Evaluation of the individual susceptibility through the analysis ‐from "buccal swab"‐ of genetic polymorphisms of phase 1 enzymes (CYPs) and phase 2 (GSTs) in subjects exposed to benzene and ethical aspects, liceity of screening genetic application in wor 31,75 biomedica Genes, Genomes and Genetics € 70.000,00 2688 GR‐2009‐1575642 BIOMARKERS FOR THE EVALUATION OF INFLUENCE OF TOBACCO SMOKING ON THE PROGRESSION OF NEURODEGENERATIVE DISEASES clinico assistenziale Brain Disorders and Clinical Neuroscience € 455.000,00 32 € 470.000,00 € 430.231,00 Pagina 237 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2689 GR‐2009‐1608499 Efficacy, Safety and Pharmacokinetics of Rituximab in Refractory Nephrotic Syndrome due to Primary Glomerulonephritis: Correlation with clinical outcomes and laboratory markers. 32 biomedica Digestive, Kidney and Urological Systems € 0,00 2690 GR‐2009‐1584345 Stem cell therapy for end‐stage liver disease due to non‐alcoholic steatohepatitis 32 biomedica Digestive, Kidney and Urological Systems € 455.628,00 2691 GR‐2009‐1584678 Neuropsychological assessment and rehabilitation in brain cancer patients: a multidisciplinary approach 32 clinico assistenziale Biobehavioral and Behavioral Processes € 272.500,00 2692 GR‐2009‐1528777 Different significance among critical factors affecting effectiveness of the most important biological stimulators in regenerative medicine of orthopedics and traumatology. 32 biomedica Musculoskeletal, Oral and Skin Sciences € 292.000,00 2693 GR‐2009‐1578341 The ability to maintain and retrieve delayed intentions. A study on the neurocognitive and morphological aspects of prospective memory and its modulation in individuals with Parkinsons disease. 32 clinico assistenziale Biobehavioral and Behavioral Processes € 341.000,00 2694 GR‐2009‐1606877 Comparison between two different types of therapeutic groups for Eating Disorders, a trial to appraise non inferiority and costs of CBT versus 12 step program 32 clinico assistenziale Biobehavioral and Behavioral Processes € 77.000,00 2695 RF‐2009‐1505801 Medical or Endovascular Treatment for Renal Artery Stenosis (METRAS): a randomized study. 32,17 clinico assistenziale Vascular and Hematology € 305.000,00 2696 RF‐2009‐1527749 Correlation between environmental pollution and malignant cancer in areas of high risk of exposure in the Puglia Region of Italy. 32,17 clinico assistenziale Population Sciences and Epidemiology € 400.000,00 2697 GR‐2009‐1606854 Randomized controlled trials on the prevention of alcohol misuse among adolescents through the dissemination of school‐based and web‐based Metacognitive Prevention of Alcohol Use programme [M‐PAU] 32,25 clinico assistenziale Risk, Prevention and Health Behavior € 309.500,00 2698 GR‐2009‐1569628 STUDY OF THE DIFFERENT GENE EXPRESSION IN PERIFERAL LYMPHOLCYTES AND IN PRIMARY/RECURRENT OVARIAN CANCER NEOPLASTIC TISSUE THROUGH DNA/PROTEIN MICROARRAY AND REAL TIME PCR ANALYSIS. 32,5 biomedica Oncology 1 ‐ Basic Translational € 310.222,00 Pagina 238 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2699 GR‐2009‐1607069 Collaborative environment for Clinical Audit by integration of NUI (Natural User Interface), Surface Computing, 3D Dynamical Visualization and Imaging Fusion technique 32,5 biomedica Healthcare Delivery and Methodologies 2700 GR‐2009‐1607743 Correlation between imaging and genetic data for early diagnosis of Alzheimer Disease 32,5 clinico assistenziale Brain Disorders and Clinical Neuroscience 2701 RF‐2009‐1549541 HEALTH, BEHAVIOUR AND SOCIOENVIRONMENTAL FACTORS IN ADULTS WITH INTELLECTUAL DISABILITY 32,5 clinico assistenziale Healthcare Delivery and Methodologies € 200.000,00 2702 RF‐2009‐1494020 Animal model of pharmacological modification of the blood brain barrier to increase accumulation of anticancer drugs within brain tumor tissue 32,75 biomedica Brain Disorders and Clinical Neuroscience € 329.000,00 2703 GR‐2009‐1606748 Ivabradine for heart rate control in heart transplanted patients: a clinical study. 33 clinico assistenziale Cardiovascular and Respiratory Sciences € 270.000,00 2704 GR‐2009‐1607278 Differential biomolecular involvement of intracellular pathways during the progression from myocardial hypertrophy to heart failure in the aortic stenosis 33 biomedica Cardiovascular and Respiratory Sciences € 222.000,00 2705 GR‐2009‐1607771 Hormonal peptides and intestinal mucosal proteins as possible factors predisposing to weight regain after a period of weight loss. 33 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences 2706 GR‐2009‐1605009 Coping Strategy and Quality of life in Patients with moderate to severe stroke 33 clinico assistenziale Risk, Prevention and Health Behavior 2707 GR‐2009‐1596733 In vitro and in vivo models to assess calcium homeostasis in Alzheimer's disease and to explore its involvement in the beneficial effects of environmental enrichment. 33 biomedica Emerging Technologies and Training in Neurosciences € 600.000,00 2708 RF‐2009‐1491570 Randomized Clinical Trial to confront the efficacy of treatment in patients with grade 2 and grade 3 obesity, of low calory diet Vs entheral ketogenic nutrition Vs oral ketogenic nutrition. 33 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 597.987,00 2709 GR‐2009‐1546473 Setting up a new method for the determination of nitrites and nitrates in vegetables and baby food biomedica Biological Chemistry and Macromolecular Biophysics € 200.000,00 33,25 € 298.000,00 € 382.150,00 € 511.350,00 € 250.350,00 Pagina 239 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2710 GR‐2009‐1592107 Dysfunctions in biogenesis of lysosome pathways in Parkinson Disease 33,5 biomedica Molecular, Cellular, and Developmental Neuroscience € 428.500,00 2711 GR‐2009‐1476118 How to revert the disease progression from chronic and persistent HCV infection to the hepatocellular carcinoma: a metabolic way 33,5 clinico assistenziale Oncology 1 ‐ Basic Translational € 525.000,00 2712 RF‐2009‐1539779 Cardiovascular risk in sistemic sclerosis 33,67 clinico assistenziale Cardiovascular and Respiratory Sciences € 470.000,00 2713 GR‐2009‐1583788 Epilepsy and Hirsutism 33,75 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 150.000,00 2714 GR‐2009‐1608182 Detection of Bacillus anthracis in contaminated soils by immunomagnetic method 34 biomedica Infectious Diseases and Microbiology € 210.000,00 2715 RF‐2009‐1475670 Multiple Myeloma (MM) and Osteo‐ Immunology: role of Notch in the expression of chemokines and cytokines as new predictive markers 34 biomedica Musculoskeletal, Oral and Skin Sciences € 222.700,00 2716 GR‐2009‐1594617 SENTINEL LYMPH NODE BIOPSY BY INDOCYANINE GREEN FLUORESCENCE IN BREAST CANCER VS RADIOCOLLOID MAPPING PROCEDURE 34,5 clinico assistenziale Oncology 2 ‐ Translational Clinical € 350.000,00 2717 GR‐2009‐1584515 Impact of Surgical Treatment of the Hyperparathyroidism on Cardiovascular Risk. Evaluation of Coronary Microvascular Function Before and After Parathyroidectomy Performed with Transthoracic Doppler Echocardiography. 34,5 clinico assistenziale Cardiovascular and Respiratory Sciences € 285.000,00 2718 GR‐2009‐1607880 Non invasive monitoring of hepatic steatosis in patients with HIV infection undergoing orthotopic liver transplantation: a pilot case‐control study based on Magnetic Resonance Spectroscopy 34,5 clinico assistenziale AIDS and Related Research € 252.000,00 2719 RF‐2009‐1511629 Advanced Molecular BioMedicine of Complex Systems: Molecular Analysis of the MicroRNA Transcriptome in Breast and Colorectal Carcinoma through High Throughput Technology to Identify Diagnostic and Prognostic Biomarkers 34,5 biomedica Genes, Genomes and Genetics € 588.000,00 2720 RF‐2009‐1550707 THE DEVELOPMENT OF A BEST PRACTICE MODEL TO PALLIATIVE CARE: AN EVALUATION RESEARCH IN SICILY clinico assistenziale Healthcare Delivery and Methodologies € 225.000,00 35 Pagina 240 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2721 RF‐2009‐1511217 Neurobehavioral problems in autistic spectrum disorder patients undergoing pediatric dentistry care: an observational and experimental study aimed at an innovative, tailored approach in special‐needs patients. 35 clinico assistenziale Biobehavioral and Behavioral Processes € 259.600,00 2722 GR‐2009‐1575424 Cell initiating human acute myeloid leukemia: dissecting progenitor‐cell driven trascriptional programs 35 biomedica Oncology 1 ‐ Basic Translational € 210.000,00 2723 GR‐2009‐1606635 Development of a 3D imaging system for breast volume, shape and symmetry assessment in preoperative planning and follow up in breast reconstructive surgery after mastectomy, quadrantectomy and for developmental breast asymmetries 35 clinico assistenziale Bioengineering Sciences and Technologies € 105.400,00 2724 GR‐2009‐1607261 Genomic microarrays in mental retardation: from research to diagnosis 35 clinico assistenziale Genes, Genomes and Genetics 2725 RF‐2009‐1549898 Prevention of Pressure Ulcers: a different nursing model 35 clinico assistenziale Healthcare Delivery and Methodologies € 465.000,00 2726 GR‐2009‐1607414 Colorectal surgery in very old people. Perspectives and new surgical approaches with particular reference to advanced laparoscopic surgery: indications, timing, surgical techniques and application protocols. 35 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 335.000,00 2727 RF‐2009‐1548587 Global ingestion by foodstuffs of some toxic contaminants: calculation of total exposure for every balanced diet differing classes of Italian people for age, dietary systems and clinical conditions. 35 biomedica Veterinary ‐ Food Safety ‐ FOSA € 540.000,00 2728 GR‐2009‐1607909 Population based epidemiology of early acquired disabilities: to qualify and quantify the unmet care needs of disabled individuals, to explore their avoidability to field test innovative interventions. 35 clinico assistenziale Population Sciences and Epidemiology € 489.500,00 2729 RF‐2009‐1519742 VIRO‐IMMUNOLOGICAL FACTORS INVOLVED IN THE POST‐LIVER TRANSPLANT HCV RE‐INFECTION AND IN THE RESPONSE TO SUBSEQUENT ANTIVIRAL TREATMENT 35 biomedica Infectious Diseases and Microbiology € 550.000,00 2730 RF‐2009‐1539867 Prematurity and low birth weight: probable cause of increased cardiovascular risk in adulthood 35,25 biomedica Cardiovascular and Respiratory Sciences € 242.000,00 2731 GR‐2009‐1591088 Screening for Hereditary Hemochromatosis on Blood Donors from Lazio 35,5 clinico assistenziale Genes, Genomes and Genetics € 190.000,00 € 0,00 Pagina 241 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2732 GR‐2009‐1584591 Minimally Invasive Thoracic Surgery 35,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 168.000,00 2733 GR‐2009‐1606757 EVALUATION AN INTERVENTION MEASURES ON QUALITY OF LIFE OF CHILDREN BORN WITH ANO‐RECTAL MALFORMATION 35,5 clinico assistenziale Biobehavioral and Behavioral Processes € 308.000,00 2734 RF‐2009‐1474927 GENOMICS AND METABOLOMICS PROFILINGS OF MYELODYSPLASTIC SYNDROMES AND MULTIPLE MYELOMA 35,5 biomedica Genes, Genomes and Genetics € 380.000,00 2735 RF‐2009‐1537006 Project MOICA ‐ Integrated Model of Continuity of Care between hospital and social setting of Primary Health Care (PHC) for problems and Alcohol‐related harm 35,67 clinico assistenziale Risk, Prevention and Health Behavior € 475.000,00 2736 RF‐2009‐1538830 Platelet aggregation tests in diabetic patients in clinical practice 35,67 clinico assistenziale Cardiovascular and Respiratory Sciences 2737 RF‐2009‐1545578 Prevention of Worsening of Chronic Disease and Drug‐Drug Interaction by A Simple Tool in Postmenopausal Women 36 clinico assistenziale Healthcare Delivery and Methodologies 2738 RF‐2009‐1474983 Myocardial infarction and remodeling: at the heart of the problem 36 biomedica Cardiovascular and Respiratory Sciences € 413.000,00 2739 RF‐2009‐1511961 HIGH DOSE RATE BRACHYTHERAPY WITH OR WITHOUT EXTERNAL‐BEAM RADIATION THERAPY IN PATIENTS WITH PROSTATE CANCER 36,25 clinico assistenziale Oncology 2 ‐ Translational Clinical € 241.220,00 2740 GR‐2009‐1470060 Efficacy of a new multisensory stimulation in SV and SMC patients. 36,25 clinico assistenziale Brain Disorders and Clinical Neuroscience € 330.875,00 2741 GR‐2009‐1579132 Microarray as diagnostic tool to risk assessment in alimentary field; development, standardization and validation of multidiagnostic platforms to monitor bacteria and fungal pathogens in food. 37 biomedica Veterinary ‐ Food Safety ‐ FOSA € 302.500,00 2742 GR‐2009‐1603030 Autosomal Recessive Spastic Ataxia of Charlevoix‐Saguenay: functional study of the gene and its role in the pathogenesis of neurodegeneration autophagy‐ mediated 38 biomedica Molecular, Cellular, and Developmental Neuroscience € 312.000,00 € 18.000,00 € 400.000,00 Pagina 242 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 2743 GR‐2009‐1595875 Deregulation of methylation in X‐linked brain expressed genes and correlation with structural and functional brain abnormalities in patients with Idiopathic Autism Spectrum Disorders 38 biomedica Genes, Genomes and Genetics € 310.000,00 2744 RF‐2009‐1539583 Mutations and/or Polymorphism in vitamin D pathway genes,vitamin D levels and allergic asthma 39 biomedica Cardiovascular and Respiratory Sciences € 245.122,00 2745 RF‐2009‐1550858 The use of probiotics as factors to improve the immune response of vaccines administered during epidemic emergencies. Identification of the animal model and utilize of anthrax vaccine for human use. 39 biomedica Immunology € 290.500,00 2746 RF‐2009‐1548313 Development of techniques and methods for diagnosing and treating nephrolithiasis. 40 clinico assistenziale Digestive, Kidney and Urological Systems € 150.000,00 2747 RF‐2009‐1549439 CONI Project:Relationship between metabolic diseases, lifestyle and nutrition in childhood 40 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences € 210.000,00 2748 RF‐2009‐1535089 Outcome research in oncology: a prospective study evaluating the effectiveness of different treatments and strategies in cancer patients 40 clinico assistenziale Healthcare Delivery and Methodologies € 438.350,00 2749 GR‐2009‐1573611 Monitoring and molecular characterization of vector insect population on sicilian territory and research of viral agents to them potentially associated 40 biomedica Infectious Diseases and Microbiology € 450.000,00 2750 GR‐2009‐1600299 Bone Marrow Cell Transplantation in Acute Anterior Myocardial Infarction Patients 40,5 clinico assistenziale Cardiovascular and Respiratory Sciences 2751 RF‐2009‐1545622 Team Mental Model: a new measurament performance methods to evaluate a social‐health services that are interdependent and organised as an Hub&Spoke Network. 40,5 clinico assistenziale Healthcare Delivery and Methodologies € 590.000,00 2752 GR‐2009‐1608706 EVALUATION OF IMMEDIATE, MID TERM AND LONG TERM RENAL FUNCTION DAMAGE FOLLOWING DIFFERENT NEPHRON SPARING TECHNIQUES (OPEN NEPHRON SPARING SURGERY, LAPAROSCOPIC/ROBOTIC NEPHRON SPARING SURGERY AND LAPAROSCOPIC RENAL CRYOABLATION) 41 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering € 325.000,00 € 0,00 Pagina 243 di 244 BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI ‐ Graduatoria ID CODICE PROGETTO Punteggio AREA Classificazione 1 Liv. Finanziamento Richiesto 41,34 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering € 379.000,00 Adiponectin involvement in the proliferation and differentiation of human glioblastoma tumor stem cells. 42 biomedica Oncology 1 ‐ Basic Translational € 495.000,00 INVASION MECHANISMS OF BRAIN TUMOR STEM CELLS 44 biomedica Oncology 1 ‐ Basic Translational € 600.000,00 2753 GR‐2009‐1607738 Automatic method for hepatic lesions extraction from multiphase CT images: a new approach for the assessment of the lesions response to therapy. 2754 GR‐2009‐1592093 2755 GR‐2009‐1579813 Pagina 244 di 244
