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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES BANGALORE, KARNATAKA ANNEXURE - II APPLICATION FOR REGISTRATION OF SUBJECTS FOR DISSERTATION 1 NAME OF THE CANDIDATE AND ADDRESS 2 NAME OF THE INSTITUTION COURSE OF STUDY AND SUBJECT M.D(HOMOEO) – REPERTORY 3 Dr.PRASHANTH.C PG STUDENT , DEPT OF REPERTORY H.K.E.SOCIETY’S HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL , GULBARGA585105 H.K.E.SOCIETY’S HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL, GULBARGA. DATE OF ADMISSION TO THE COURSE 20/10/2011 5 TITLE OF THE TOPIC “ CLINICAL UTILITY OF MINTON’S UTERINE THERAPEUTICS IN TREATMENT OF DYSFUNCTIONAL UTERINE BLEEDING ” 6 BRIEF RESUME OF THE INTENDED WORK 4 6.1 NEED FOR STUDY The DYSFUNCTIONAL UTERINE BLEEDING is a condition where there are no demonstrable structural or any other extra genital causes for the excessive bleeding. And is commonly found among the women aged between 30 to 50 but it is becoming more common around the menarche and peri menopause due to stress, especially emotional stress, grief, excessive use of contraceptives and hormonal therapy. So the number of women presenting with this complaint are increasing day by day. In allopathy there is no permanent cure for dysfunctional uterine bleeding the reason being that they only treat the symptoms of the disease but not the patient as a whole. Their method of treatment is only to relieve the symptoms by infusing drugs like hormonal 2 supplements, analgesics for pain, anti inflammatory drugs, and when the symptoms are not relieved by these drugs they opt for surgical procedures like oophorectomy, uterine packing and lastly hysterectomy. Thus instead of giving relief to the patient these grave procedures worsen the patient’s condition with many complications like metorrhoegia and some somato-psychic disorders. In this regard, it’s the system of HOMOEOPATHY with its principle of individualistic and holistic approach plays a ‘VITAL ROLE’. That is it intends to cure the person as a whole with consideration of the psychological, social and biological aspects rather than considering only the clinical symptoms and ultimates (end results) of the disease. Because the cure constitutes restoration of the sick to cure as it termed. Henry Minton’s repertory of uterine therapeutics is based on the philosophy of general to particular. This repertory is usefull monograph on the problems of menstruation and other related functions. The author has collected and arranged systematically in a convenient form all those symptoms of materia medica that have any direct or specific bearing upon the subject of uterine disorders. In this regard it’s my privilege being an homoeopath I would like to take up this task in order to understand its clinical utility in the management of dysfunctional uterine bleeding, since it serves to be a very usefull tool and thus serving the purpose or need of study. 6.2 REVIEW OF LITERATURE 1. Henry Minton, Uterine therapeutics – (clinical repertory ) B-Jain Publishers New Delhi.1999 A clinical repertory on uterine therapeutics. It has two parts, First Part contains remedies and their 3 indications Second part deals with repertory in which the rubrics are arranged alphabetically. The gradings used are italic and ordinary roman. 2. Harsh Mohan, Text book of pathology 5th edition, pg no : 758, Jaypee Brother’s Medical Publishers(P)Ltd New Delhi. Text book of pathology says Dysfunctional uterine bleeding is excessive bleeding which occurs during or between the menstrual periods without causative uterine lesions such as tumor, polyp, infection, hyperplasia, trauma, blood dyscrasia or pregnancy. 3. Dr.Kent.J.T ,Repertory Of Homoeopathic Materia Medica , B.Jain publication , 6th American edition , Aug 2005. Some of the rubrics found in kent’s repertory for dysfunctional uterine bleeding are MENSES-copious-pg no: 725,726 MENSES-frequent-pg no:726 METRRORHAGIA-729-731 4. Medline plus ( NATIONAL INSTITUTE OF HEALTH ).com Dysfunctional uterine bleeding (DUB) is abnormal bleeding from the vagina that is due to changes in hormone levels. Dysfunctional uterine bleeding (DUB) most commonly occurs when the ovaries do not release an egg. Changes in hormone levels cause your period to be later or earlier and sometimes heavier than normal. About every month, the levels of female hormones in a woman's body rise and fall. Estrogen and progesterone are two very important hormones. 4 5. Padubidri VG and Shirish N Daftary, Shaw’s Text Book Of Gynecology Elsevier publication 14th edition, page no : 269 In a number of patients menorrhagias is not associated with any structural abnormality, disease in the pelvis or evidence either of general or endocrine disease. If on bimanual examination the uterus and appendages are found to be normal, the term Dysfunctional uterine bleeding is used. The aetiology is purely hormonal and that the hypertrophy and hyperplasia of the endometrium are induced by a high titre of oestrogens in the circulating blood. 6. DR.ASRANI. C.H ,National Journal Of Homoeopathy, Vol-11 ,Jan -2009 pg no 10-11. DUB dysfunctional uterine bleeding-any vaginal bleeding that is not related to a women’s normal menstrual pattern, any abnormal uterine bleeding for which no organic cause can be demonstrated is called DUB. 7. Understanding Dysfunctional Uterine Bleeding.com Dysfunctional uterine bleeding (also known as DUB) is a collective term for classifying six separate conditions all relating to uterine bleeding. These conditions vary from an absence of bleeding (amenorrhea) to heavy and excessive bleeding (menorrhagia).Menstrual blood flow is mostly controlled by the hormones estrogen and progesterone. Estrogen stimulates a buildup of the uterine lining and progesterone holds the lining together. There is a fine balance between the two and if there is a disruption to one or both hormones, often the disruption can be reflected in menstrual bleeding changes. 8. Teens health.com/dub When a girl's period is irregular, doctors may diagnose her with something called dysfunctional uterine bleeding (DUB). DUB can cause periods that last longer or have 5 more bleeding than normal.DUB isn't usually a problem on its own. In fact, doctors often don't do anything to treat mild cases. But DUB can affect the health of some girls. The most common worry is that a girl might develop anemia if she's bleeding more than she should. 9. Medscape.com/dub Dysfunctional uterine bleeding (DUB) is defined as abnormal uterine bleeding in the absence of organic disease. Dysfunctional uterine bleeding is the most common cause of abnormal vaginal bleeding during a woman's reproductive years. Dysfunctional uterine bleeding can have a substantial financial and quality-of-life burden.[1] It affects women's health both medically and socially. 10. Web health.com/dub Dysfunctional uterine bleeding is the most common abnormality of a woman’s menstrual cycle. Ordinarily the first day of the period would be 28 days (26 to 30 range) apart. When there has not been an ovulation in the ovary (no egg release) in that cycle, it causes a dysfunctional bleeding. In 50% of cases, this happens in women older than 45 years; 20% in adolescents. 11. Women livingnaturally.com/dub The term "dysfunctional uterine bleeding" is used to describe heavy vaginal bleeding that isn't caused by a serious medical problem. In most cases, heavy often irregular bleeding is related to abnormal hormone levels that throw off the menstrual cycle. Dysfunctional uterine bleeding is not used to describe vaginal bleeding caused by medical conditions such as miscarriage, uterine growths such as fibroids, cancer of the cervix or uterus or blood diseases. If you are having heavy vaginal bleeding, your health professional must rule out these other conditions before diagnosing you with dysfunctional uterine bleeding. 6 6.3 OBJECTIVES OF THE STUDY 1) To know the utility of Minton’s uterine therapeutics in the treatment of dysfunctional uterine bleeding. 2) To evolve a group of efficacious homoeopathic remedies in the management of dysfunctional uterine bleeding. 7 MATERIALS AND METHODS 7.1 SOURCES OF DATA 7.2 METHOD OF COLLECTION OF DATA H.K.E.SOCIETY’S HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL (IPD’S AND OPD’S) GULBARGA. Including sampling procedure if any. 1. 2. 3. 4. 5. By interrogation of individual case By physical examination of the patient By laboratory investigation Sample size: 30 cases Sampling procedure: simple random sampling technique. 6. Statistical data analysis: all the variables are qualitative ones by applying test, data can be analyzed. 7. Inclusion criteria: Female Patients of middle age between 30-50 years. Irrespective of their socioeconomic status. 8. Exclusion criteria: subjects who are with uterine fibroid, carcinoma of cervix, carcinoma of uterus. 9. Duration of study: 01-05-2012 to 30-04-2014 7 8 7.3 DOES THE STUDY REQUIRE ANY INVESTIGATION TO BE CONDUCTED ON PATIENTS OR OTHER HUMANS OR ANIMALS? IF SO, PLEASE DESCRIBE BRIEFLY. ETHICAL 7.4 HAS CLEARANCE BEEN OBTAINED FROM YOUR INSTITUTION LIST OF REFERENCES 1. Henry Minton, Uterine therapeutics – (clinical repertory ) B.Jain publication New Delhi, 1999 2. Harsh Mohan, Text book of pathology 5th edition. Jaypee Brother’s Medical Publishers(P)Ltd New Delhi. 3. Dr.Kent.J.T , Repertory Of Homoeopathic Materia Medica , B.Jain publication, 6th American edition, Aug 2005. 4. Medline plus ( NATIONAL INSTITUTE OF HEALTH ).com 5. Padubidri VG and Shirish N Daftary , Complete blood count (CBC) Blood clotting profile Hormone tests like FSH ,LH and Thyroid function tests Pap smear and culture to look for infection Biopsy Transvaginal ultrasound Ultrasonography–abdomen ( lower abdomen) YES ethical clearance has been obtained from our institution. Shaw’s Text Book Of Gynecology Elsevier publication,14th edition. 6. DR.ASRANI.C.H ,National Journal Of Homoeopathy Vol-11, Jan -2009 7. Understanding Dysfunctional Uterine Bleeding.com 8. Teens health.com/dysfunctional uterine bleeding. 9. Medscape.com/Dysfunctional uterine bleeding. 10. Web health.com/dub 11. Women livingnaturally.com/dub 8 9 10 SIGNATURE OF THE CANDIDATE REMARKS GUIDE OF THE 11 NAME AND DESIGNATION OF (IN BLOCK LETTERS) 11.1 GUIDE Dr.VIJAYLAKSHMI.B.M M.D.(HOMOEO) PROF.DEPARTMENT OF REPERTORY H.K.E.SOCIETY’S HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL, GULBARGA. 11.2 SIGNATURE OF THE GUIDE 11.3 CO-GUIDE ANY) 11.4 SIGNATURE 11.5 HEAD OF THE DEPERTMENT 11.6 SIGNATURE 12.1 REMARKS OF CHAIRMAN & PRINCIPAL 12.2 SIGNATURE 12 (IF Dr.S.KRISHNA M.D.(HOMOEO) PROF & HEAD DEPARTMENT OF REPERTORY H.K.E.SOCIETY’S HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL, GULBARGA.