Download Tasks for 1stMidtermExam. Introduction. Metabolic Regulation

Tasks for 1stMidtermExam.
1. Introduction. Metabolic Regulation
2. Introduction to biochemistry. Vitamins. Enzymes. Hormones.
3. Energy metabolism
4. Carbohydratemetabolism
5. Lipid metabolism
6. Protein metabolism
7. Amino acidmetabolism. Nucleotide metabolism.
8. Protein biosynthesis
9. Unity and relationship of metabolisms
1. The second name of vitamin B12
A) External factor castle.
B) korenovo ring
C) anemia
D) factor liver
E) cobalt
2. What is the cause of deficiency of vitamin B12
A) Anemia.
B) loss of sight
C) osteochondrosis
D) cataract
E) scurvy
3. With a lack of vitamin manifested anemia
A)В12.
B)В6
C)Са
D)В2
E)К
4. What scientist first discovered vitamin B12
A)William Murphy.
B) Adam Hodgkin
C) Dorothy Crowfoot
D) Kevin Smith
E) George Vipi
5. In which year scientist Dorothy Crowfoot determined the molecular chemical
structure of vitamin B12
A)1934.
B)1956
C)1962
D)1975
E)1980
6.What vitamin involved in blood clotting?
A) Vitamin K.
B) Vitamin B6
C) Vitamin C
D) Vitamin E
E) Vitamin D
7. Lack of vitamin K is often develops in diseases
A) Liver.
B) heart
C) kidney
D) stomach
E) thyroid
8. Which vitamin provides for the conversion of prothrombin to thrombin?
A) Vitamin K.
B) Vitamin A
C) Vitamin B1
D) Vitamin E
E) Vitamin D
9. Vitamin K:
A)Iis responsible for blood clotting.
B) is called tocopherol
C) highly soluble in water
D) promotes the absorption of calcium
E) has reducing properties
10. What vitamins are fat-soluble to:
A) vitamins E,D,A,K.
B) vitamins A,D,E,C
C) vitamins A,C
D) vitaminsC,B
E) vitamins A,B
11.When it was discovered Vitamin F?
А) 1923.
В) 1930
С) 1934
D) 1882
E) 1932
12.In 1930 the two families unsaturated fatty acid are not to vitamin.
A) Fats.
B) lipids
C) proteins
D) amino acids
E) hormones
13.What is the source of slaves Vitamin F?
A) Salmon.
B) perch
C) carp
D) pike
E) whale
14.Determine acid related to Omega-3.
A) Linolenic acid.
B) sulfuric acid
C) nitrous acid
D) hydrochloric acid
E) nucleic acid
15.Determine acid related to Omega-6.
A) Linolenic acid.
B) nitrous acid
C) sulfuric acid
D) nucleic acid
E) hydrochloric acid
16. Vitamin C:
А) Water soluble.
В) fat-soluble
С) insoluble
D) acid-soluble
E) gas Soluble
17.Vitamin C is necessary for:
А) Normal growth and development.
В) slimming
C) digestion
D) breath
E) good Sleep
18) Heal wounds and form scar tissue is able to:
A) Vitamin С.
B) Vitamin B6
C) Vitamin D
D) Vitamin А
E) Vitamin B12
19. The body of vitamin C:
A) Unable to produce vitamin C on their own, does not store vitamin C.
B) get in contact with sunlight
C) produces itself
D) receives oxygen
Е) receives water
20. Vitamin C is known as a remedy for:
A) Colds.
B) diarrhea
C) joint pain
D) soreness
E) headache
21. What is vitamin A?
A) Vitamin A is a group of unsaturated nutritional organic compounds that includes
retinol, retinal, retinoic acid, and several provitamin A carotenoids.
B) Vitamin A is a group of water-soluble vitamins that play important role in cellular
metabolism
C) Vitamin A is a group of biologically active substances
D) Vitamin A refers to a group of lipophilis and hydrophobic vitamins that are
needed for protein synthesis, providing a sufficient level of coagulation
E) Vitamin A anticholesterolemic vitamin is a fat-soluble vitamin
22.What year was opened Vitamin A?
A) In 1913.
B) in 1910
C) in 1901
D) in 1900
E) in 1991
23. Find the true statement:
A) Substances of the group of vitamin A are crystalline.
B) Vitamin A is essential for building cell membranes
C) Vitamin A is prevents the deposition of cholesterol in blood
D) Vitamin A is formed in the skin by action of sunlight
E) Vitamin A is very important for energy generation
24. What in any animal products is Vitamin A?
A) Fish oil, liver, eggs, milk, butter.
B) horsemeat, sunflower oil
C) mutton, kefir
D) buckthorn, parsley
E) carrots, fish
25) What in any vegetable products is Vitamin A?
A) Green and yellow vegetables (pumpkin, sweet pepper).
B) lemon, eggplant, eggs
C) melon, pumpkin, milk
D) pear, lemon, rose hips
E) margarine, cherry
26.Who was vitamin E discovered by?
A) H.Evans and K.S.Bishop.
B) E.Cockings and G.Mendel
C) J.Lenon and W.Flemming
D) M.Karrer and F.Crick
E) H.Rehinger and F.Miescher
27.When was vitamin E discovered?
A) 1922.
B) 1932
C) 1920
D) 1933
E) 1940
28.What is vitamin E side effects?
A) Gemolytic anemia, bleeding in the brain.
B) allergy, cough
C) sneeze, stroke
D) high level of insult
E) heart disease, dementia
29.Which of these vitamin is a fat-soluble vitamin?
A) Е.
B) B12
C) B1
D) РР
E) C
30.What is vitamin E function?
A) Antioxidant.
B) synthesis
C) synthesis RNA
D) support strong bone
e) take part in water-salt metabolism
31. fat-soluble vitamins include
A) Vitamins A, D, E, K.
B) vitamin D and B
C) vitamins A, D, E, C
D) vitamin E, C
E) vitamin C
32. The development of rickets in children occurs from a lack of vitamin
A) Vitamin D.
B) vitamin B
C) Vitamin А
D) vitamin C
E) vitamin E
33. Avitaminosis:
A) Lack of vitamins.
B) excess vitamins
C) the absence of any vitamin
D) blocking vitamin certain substances
E) intolerance of the body of some vitamins
34. Vitamin D2
A) It is derived from ergosterol.
B) responsible for reproduction
C) It called phylloquinone
D) destroyed by the action of UV rays
E) soluble in water
35. Lack of vitamin causes a decrease in the activity of aminotransferases and
decarboxylases?
A) B6.
B. B2
C. B3
D. B12
E. B15
36. Determination of some transaminase activity widely used in medical practice to
diagnose internal injuries. Cofactor of these enzymes is the active form of vitamin
A) B6
B)B1.
C) B12
D) B2
E)PP
37. Determination of activity of transaminases is widely used to diagnose internal
injuries. Cofactor of these enzymes is the active form of vitamin:
A) B6.
B)B1
C) B2
D) B12
E)РР
38. When vitamin deficiency relative of vitamin A can significantly decrease
serum transaminase activity?
A) B6 (peridoksin).
B)B1 (thiamine)
C) B2 (riboflavin)
D) B5 (nicotinamide)
E)Bc (folic acid)
39. What is another name for pyridoxine?
A) Vitamin B6 .
B)Vitamin C
C) Vitamin E
D) Vitamin N
E)Vitamin G
Enzymes
1. Enzyme-driven metabolic pathways can be made more efficient by
A. concentrating enzymes within specific cellular compartments
B. grouping enzymes into free-floating, multienzyme complexes
C. fixing enzymes into membranes so that they are adjacent to each other
D. All of the above.
2. Which of the following (s) is/are serine proteases?
A. Chymotrypsin
B. Trypsin
C. Elastase
D.
all of these.
3. Which of the following statements about enzymes or their function is true?
A. Enzymes do not alter the overall change in free energy for a reaction
B. Enzymes are proteins whose three-dimensional form is key to their function
C. Enzymes speed up reactions by lowering activation energy
D.
All of the above.
4. Tryprotophan synthetase of E.coli, a typical bifunctional oligomeric enzyme
consist of
A. a protein designated A
B.
Two proteins designated A and B.
C. a protein A and one-subunit a
D. a protein designated B
5. What is the specificity of the Clostripain protease?
A.
It cleave after Arg residues.
B. It cleave after His residues
C. It cleave after Lys residues
D. None of the above
6. The proteolysis rate enhancement by chymotrypsin (~1010 folds) corresponds to
a reduction in activation energy of about
A. 40 kJ/mol
B. 49 kJ/mol
C.
58 kJ/mol.
D. 88 kJ/mol
7. Which of the following is false statement with regard to comparison between
Serine and HIV proteases?
A. Both use nucleophilic attack to hydrolyze the peptide bond
B. Both require water to complete the catalytic cycle
C.
Both forms an acyl-enzyme intermediate.
D. Both show specificity for certain amino acid sequences
8. In the enzyme-catalyzed reaction shown below, what will be the effect on
substances A, B, C, and D of inactivating the enzyme labeled E2? A ---(E1)---> B
---(E2)---> C ---(E3)--->
A. A, B, C, and D will all still be produced
B. A, B, and C will still be produced, but not D
C.
A and B will still be produced, but not C or D.
D. A will still be produced, but not B, C, or D
9. The nucleophile in serine proteases is
A. Serine
B. water
C.
both (a) and (b).
D. Asparagine
10. The role of Asp 102 and His 57 during trypsin catalysis is to
A. neutralize the charge on the other's side chain
B. keep the specificity pocket open
C.
function as a proton shuttle.
D. clamp the substrate into the active site
11. The cleavage specificity of trypsin and chymotrypsin depend in part on the
A. proximity of Ser 195 to the active site or specificity pocket
B.
size, shape, and charge of the active site or specificity pocket.
C. presence of a low-barrier hydrogen bond in the active site or specificity
pocket
D. absence of water in the active site
12. The E.coli pyruvic acid dehydrogenase complex is reported to
A. decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
B.
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2.
C. retard the reduction of pyruvic acid to acetyl Co A and CO2
D. Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
13. Which of the common features are shared between serine and aspartate
proteases?
A. Both require water to complete the catalytic cycle
B. Both use a base to activate the nucleophile
C. Both show specificity for certain amino acid sequences
D.
All of the above.
14. Before they can react, many molecules need to be destabilized. This state is
typically achieved through
A. changing the three-dimensional shape of the molecule
B. oxidizing the molecules by removing electrons
C. changing the reaction from a biosynthetic to a catabolic pathway
D.
the input of a small amount of activation energy.
15. Common feature in all serine proteases is a
A. hydrophobic specificity pocket
B. hydrophilic specificity pocket
C. cluster of reactive serine residues
D.
single reactive serine residue.
16. How is the enzyme COX-1 important in human health?
A. It helps to transport carbon dioxide in the blood
B. It is critical for the biosynthesis of DNA
C. It is a chemical derivative of aspirin
D.
It catalyzes the production of hormones that maintain the stomach lining.
5. A kinase is an enzyme that
A. removes phosphate groups of substrates
B.
uses ATP to add a phosphate group to the substrate.
C. uses NADH to change the oxidation state of the substrate
D. removes water from a double bond