Download CV - University of Minnesota School of Dentistry

BIOGRAPHICALSKETCH
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NAME
POSITION TITLE
KO, Ching-Chang
Professor of Orthodontics
eRA COMMONS USER NAME
CHING-CHANG_KO
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
Kaohsiung Medical University, Taiwan, R.O.C.
National Yang-Ming Medical Univ., Taiwan, R.O.C.
University of Michigan, Ann Arbor, MI, USA
DDS
MS
PhD
07/1984
07/1989
06/1994
University of Minnesota; Minneapolis, MN, USA
Certificate
06/2006
FIELD OF STUDY
Dentistry
Bioengineering
Bioengineering &
Biomaterials
Orthodontics
A. Personal Statement
One of my research goals is to develop the rigid biomimetic material scaffolds with stem cell-based therapy for
craniofacial bone regeneration. I invented the biomimetic synthesis that produces hydroxyapatite-gelatin
nanocomposites (HAP-GEL). Since I developed this HAP-GEL system 15 years ago, my laboratory has
continuously evolved new modifications. I am currently developing a newer version of HAP-GEL, from which
new bone cement and printable scaffolds can be synthesized. Prior to developing HAP-GEL, I also studied
dental biomechanics since 1990 and have never stopped biomechanical research in implant design and bone
remodeling. My laboratory equips facilities to perform the proposed biomechanical study. I am currently funded
by NIDCR to develop new polydopamine-laced hydroxyapatite-gelatin (HAP-GEL) nanocomposites and
investigate biomechanics of a nanocrystalline material in orthodontics. In addition, I successfully administered
the projects (e.g. staffing, research protections, budget), collaborated with other researchers, nurture
academicians, and produced more than 100 peer-reviewed publications. In summary, I am a bone bioengineer
who has a demonstrated record of accomplished and productive research projects in an area of high relevance
to this proposed study.
B. Positions and Honors
Positions and Employment
1984-1986
Army Dentist, Taiwan, R.O.C.
1987-1989
Graduate Res Assist, Biomedical Engineering, Yang-Ming University, Taiwan, R.O.C.
1990-1994
Graduate Research Assistant, Biological and Materials Sciences, Univ. of Michigan, USA
1994-1997
Postdoc Research Associate, Dept. of Oral Science / MDRCBB, Univ. of Minnesota, USA
1997-2006
Research Assistant Professor, Dept. of Oral Science / MDRCBB, Univ. of Minnesota, USA
2006-2011
Associate Professor, Dept. of Orthodontics, Univ. of North Carolina, Chapel Hill, USA
2007-2012
Associate Professor, Applied & Materials Sciences Program, Univ. of North Carolina, Chapel Hill,
USA
2010Adjunct Professor, Dept. of Material Science and Engineering, School of Engineering,
North Carolina State University, Raleigh, NC, USA
2012Professor, Dept. of Orthodontics, Univ. of North Carolina, Chapel Hill, USA
2013Program Director & Vice Chair, Dept. of Orthodontics, Univ. of North Carolina, Chapel Hill, USA
2014Dr. Fred Hale Distinguished Professor, Univ. of North Carolina, Chapel Hill, USA
Other Experience and Professional Memberships
2012-Present Member, Orthopedic Research Society (ORS)
2008-Present Member, American Ceramic Society (ACerS), Materials Research Society (MRS)
1990-Present Member, American Association for Dental Research (AADR)
1990-Present Member, International Association for Dental Research (IADR)
2006-Present Member, American Association of Orthodontists (AAO)
Honors
1991
1993
1998
2004-2006
2005
2007
2007-2022
2009
2009
2014
2014
2016
2016
Univ. Council on International Academic Affairs Grant Award, Univ. of Michigan
Rackham Research Partnership Award, Univ. of Michigan
Whitaker Foundation Biomedical Research Award
MinnCrest Clinical Fellow (Specialize in Orthodontics)
Organizer, MRS (Material Research Society) Fall Symposium: Mechanical Behavior of Biological
and Biomimetic Materials, Boston.
BF Dewell Memorial Research Award, AAOF (Am. Ass oc. of Orthodontists Foundation)
Diplomat of the American Board of Orthodontics.
Faculty Lecture Award, Southern Association of Orthodontists.
Faculty of Year in Full Time Teaching, Department of Orthodontics at UNC
Faculty Member, Omicron Kappa Upsilon (OKU) Dental Honor Society
Faculty of Year in Full Time Teaching, Department of Orthodontics at UNC
Fellow of the ADEA Leadership Institute
Faculty of Year in Full Time Teaching, Department of Orthodontics at UNC
C. Journal Articles (Peer-Reviewed), out of 120
1. Olafsson V, Ritter A, Swift E, Boushell L, Ko CC, Jackson G, Ahmed S, Donovan T. Effect of
Composite Type and Placement Technique on Polymerization Shrinkage Stress. Submitted to J
Operative Dentistry. 2016.
2. Hu H, Dyke J, Bowman B, Ko CC, You W. Investigation of Dopamine Analogues: Synthesis,
Mechanistic Understanding, and Structure-Property Relationship. Submitted to Langmuir. 2016.
3. Jackson T, Guez C, Lin F-C, Proffit W, Ko CC. The Modern Likelihood of Orthodontic Tooth
Extraction. Accepted to AJODO. 2016.
4. Uhlir R, Mayo V, Lin PH, Chen S, Lee Y-T, Garland H, Adalsteinsson D, Lin F-C, Ko CC.
Biomechanical Characterization of the Periodontal Ligament: Orthodontic Tooth Movement. In
Press. Angle Orthodontist. 2016.
5. Kim Y-I, Ko CC. Comparison of post-operative distal segment changes between conventional and
sliding mini-plate fixation methods. In Press. The Korean Journal of Orthodontics. 2016.
6. Choi Y-K, Kim J, Yamaguchi T, Maki K, Ko CC, Kim Y-I. Cervical Vertebral Body’s Volume as a New
Parameter for Predicting the Skeletal Maturation Stages. BioMed Research International, 2016.
http://dx.doi.org/10.1155/2016/8696735.
7. Lee DJ, Park Y, Hu W-S, Ko CC. Osteogenic potential of Multipotent Adult Progenitor Cells
(MAPCs) for Calvaria Bone Regeneration. Advances in Medicine. vol. 2016, Article ID 2803081, 11
pages, 2016. doi:10.1155/2016/2803081.
8. Son S-A, Jung K-H, Ko CC, Kwon YH. Spectral characteristics of caries-related autofluorescence
spectra and their use for diagnosis of caries stage. J Biomed Opt. 2016 Jan 1;21(1):15001. doi:
10.1117/1.JBO.21.1.015001.
9. Byun B-R, Kim Y-I, Yamaguchi T, Maki K, Ko CC, Hwang D-S, Park S-B, Son W-S. Quantitative
skeletal maturation estimation using cone-beam computed tomography-generated cervical
vertebral images: a pilot study in 5- to 18-year-old Japanese children. Clin Oral Invest. 2015,
19:2133-2140. DOI 10.1007/s00784-015-1415-6.
10. Kim T-W, Lee J-H, Jeong S-H, Ko CC, Kim H-I, Kwon YH. Mechanical Properties and
Polymerization Shrinkage of Composite Resins Light-Cured Using Two Different Lasers.
Photomedicine and Laser Surgery. 2015. 33(4): 213-219. DOI: 10.1089/pho.2014.3849.
11. Lee DJ, Tseng HC, Wang Z, Dong M, Zhang H, Ko CC. Dopaminergic effects on in vitro
soteogenesis. Bone Research. 3:15020. 2015. doi:10.1038/boneres.2015.20. PMID 26558139.
12. Zhang H, Yang S, Masako N, Lee DJ, Cooper L, Ko CC. Proliferation of preosteoblasts on TiO2
nanotubes is FAK/RhoA related. RSC Advances. 2015. 5:38117–38124. DOI:
10.1039/C4RA16803H. NIHMSID 685853. PMCID: PMC4467958
13. Ku R-M, Ko CC, Jeong C-M, Park M-G, Kim H-I, Kwon YH. Effect of flowability on the flow rate,
polymerization shrinkage, and mass change of flowable composites. Dental Materials Journal 2015;
34(2): 168–174. PMID: 25740163.
14. Ro JH, Son SA, Park JK, Jeon GR, Ko CC, Kwon YH. Effect of two lasers on the polymerization of
composite resins: single vs combination. Lasers Med Sci. 2015. 30:1497–1503. PMID:25895056.
15. Chiu C-K, Dong Joon Lee DJ, Chen H, Chow LC, Ko CC. In-situ hybridization of calcium silicate and
hydroxyapatite-gelatin nanocomposites enhances physical property and in vitro osteogenesis. J
Mater Sci: Mater Med. 2015, 26:92. DOI: 10.1007/s10856-015-5456-9
16. Son S-A, Park J-K, Jung K-H, Ko CC, Jeong C-M, Kwon YH. Effect of 457nm Diode-Pumped Solid
State Laser on the Polymerization Composite Resins: Microhardness, Cross-Link Density, and
Polymerization Shrinkage. Photomedicine and Laser Surgery. 33(1):3-8, 2015. DOI:
10.1089/pho.2014.3786. PMID 25549163.
17. Dyke J, You W, Ko CC, Lee DJ. The role of temperature in forming sol-gel biocomposites containing
polydopamine. J Mater Chem B Mater Biol Med. 2014. 2:7704-7711. doi:10.1039/C4TB00884G;
NIHMSID: NIHMS634448
18. Galicia JC, Naqvi AR, Ko CC, Nares S, Khan AA. MiRNA-181a regulates Toll-like receptor
agonist-induced inflammatory response in human fibroblasts. Genes and Immunity,
Jul-Aug;15(5):333-7. doi: 10.1038/gene.2014.24.
19. Lee DJ, Padilla R, Zhang H, Hu W-S, Ko CC. In Vivo Assessment of Decellularized Bone Matrix and
Calcium Silicate Incorporated Hydroxyapatite-Gelatin Nanocomposites. BioMed Research
International. 2014:837524. PMCID: PMC4098952
20. Miguez P, Terajima M, Nagaoka H, Ferreira JA, Braswell K, Ko CC, Yamauchi M. Recombinant
biglycan promotes bone morphogenetic protein-induced osteogenesis. Journal of Dental Research.
April 2014. 93(4):406-411. doi: 10.1177/0022034514521237
21. Cox, C, Nguyen T, Koroluk L, Ko CC. In Vivo Force Decay of Niti Closed Coil Springs. Am J Orthod
Dentofacial Orthop. 145(4): 505–513, April. 2014. NIHMSID#558064. YMOD4561.
D. Research Support
Ongoing Research Support
NIH/NIDCR R01DE022816-01
CC Ko (PI)
$2,107,981.00
4/1/2014-3/31/2019
Engineering Novel Bio-inspired Materials for Stem Cell-Mediated Bone Regeneration
The goal is to develop a polydopamine-laced hydroxyapatite-gelatin nancomposite scaffold for bone tissue
engineering. The neural-osseous biological effect of dopamine on osteogenesis will be investigated.
Role: PI
NIH/NIDCR R44DE022218-02
J Burns, N2Bio Inc. (PI)
$1,362,022.00
9/1/2014-8/31/2017
Phase II: Nano-Crystalline ceramic coatings for the reduction of sliding resistance of orthodontic archwires.”
The goal of this project is to develop a nanocrystal coating on orthodontic archwires to reduce friction. The
clinical trial will be performed to evaluate the efficacy of this new wire.
Role: subcontract UNC PI
Biomaterial Recharge Center “Bone Tissue Engineering”
CC Ko (PI)
$54,007.42
2011 – Present