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FOXP2
-The “Language Gene“Presentation by
Melanie Selle
&
Hüseyin Balim
Outline
•
Introduction
•
Discovery
–
–
KE-family
Pedigree of the KE family
•
Description of F0XP2
•
Function
•
FOXP2 in humanbeings
–
•
FOXP2 in animals
–
•
Developmental dyspraxia
Songbirds
Evolution Aspect and Scientific Background
–
–
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Scientists find gene 'switch' linked to speech
The importance of being human *
Mice Given 'Human' Version of Speech Gene*
•
Conclusion
•
References
Central Questions
Why can just a single gene have such a
huge impact on our language ability?
What really differs animal from human communication?
Discovery
• 1990 discovered by Myrna Gopnik
• During research on the KE family
KE family
• Affected
family members
exhibit specific language
impairment
• Disorder is associated with
a mutation in a single
autosomal-dominant gene
Pedigree of the KE family
Where is the FOXP2 gene
located?
• Correlation of sets of
small stretches of
DNA between
affected and notaffected members of
the KE family
Variations in the small
locus of the long arm
of chromosome 7