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Sites of action of hematopoietic growth factors in the differentiation and maturation of marrow cell lines. A self-sustaining pool of marrow stem cells
differentiates under the influence of specific hematopoietic growth factors to form a variety of hematopoietic and lymphopoietic cells. Stem cell factor
(SCF), ligand (FL), interleukin-3 (IL-3), and granulocyte-macrophage colony-stimulating factor (GM-CSF), together with cell–cell interactions in the marrow,
stimulate stem cells to form a series of burst-forming units (BFU) and colony-forming units (CFU): CFU-GEMM (granulocyte, erythrocyte, monocyte and
megakaryocyte), CFU-GM (granulocyte and macrophage), CFU-Meg (megakaryocyte), BFU-E (erythrocyte), and CFU-E (erythrocyte). After considerable
proliferation, further differentiation is stimulated by synergistic interactions with growth factors for each of the major cell lines—granulocyte colonySource: Hematopoietic Agents: Growth Factors, Minerals, and Vitamins, Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
stimulating factor (G-CSF), monocyte/macrophage-stimulating factor (M-CSF), thrombopoietin, and erythropoietin. Each of these factors also influences
Citation:
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37–1). and Therapeutics, 2e; 2016 Available at:
http://mhmedical.com/ Accessed: August 09, 2017
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