* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Slide ()
Survey
Document related concepts
Endomembrane system wikipedia , lookup
Tissue engineering wikipedia , lookup
Extracellular matrix wikipedia , lookup
Cell encapsulation wikipedia , lookup
Cytokinesis wikipedia , lookup
Cell growth wikipedia , lookup
Organ-on-a-chip wikipedia , lookup
Cell culture wikipedia , lookup
Programmed cell death wikipedia , lookup
List of types of proteins wikipedia , lookup
Transcript
Sites of action of hematopoietic growth factors in the differentiation and maturation of marrow cell lines. A self-sustaining pool of marrow stem cells differentiates under the influence of specific hematopoietic growth factors to form a variety of hematopoietic and lymphopoietic cells. Stem cell factor (SCF), ligand (FL), interleukin-3 (IL-3), and granulocyte-macrophage colony-stimulating factor (GM-CSF), together with cell–cell interactions in the marrow, stimulate stem cells to form a series of burst-forming units (BFU) and colony-forming units (CFU): CFU-GEMM (granulocyte, erythrocyte, monocyte and megakaryocyte), CFU-GM (granulocyte and macrophage), CFU-Meg (megakaryocyte), BFU-E (erythrocyte), and CFU-E (erythrocyte). After considerable proliferation, further differentiation is stimulated by synergistic interactions with growth factors for each of the major cell lines—granulocyte colonySource: Hematopoietic Agents: Growth Factors, Minerals, and Vitamins, Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e stimulating factor (G-CSF), monocyte/macrophage-stimulating factor (M-CSF), thrombopoietin, and erythropoietin. Each of these factors also influences Citation: Hilal-Dandan Brunton and Manual of (Table Pharmacology the proliferation, maturation, and in R, some casesLL. theGoodman function of theGilman's derivative cell line 37–1). and Therapeutics, 2e; 2016 Available at: http://mhmedical.com/ Accessed: August 09, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved