Download InVivo SCI

InVivo Therapeutics
Spinal Cord Injury Therapy
Tod Holberton, Kent Leslie, Katie Yates
Spinal Cord Anatomy
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http://www.laesieworks.com/spinal/SCIinfo01.html
Attaches from brainstem
to vertebrae
Two rows of nerve roots
Sensory and motor nerve
fibers
Three meninges
Spinal Cord Injury
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http://www.michaelwaks.com/spinal-cord-injury-attorney.html
10,000 people yearly
Trauma damages
vertebrae
Vertebrae damage
spinal cord
Descending loss of
function
"Complete" and
"Incomplete" injuries
Existing Treatments and
Therapies
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http://www.usahockey.com
Methylprednisone
Surgery
Immobilization or
traction
Occupational therapy
Scaffold Technology
• PLGA Scaffold
• 300um pore size
• Bioresorbable
• Use of stem cells
• Two different types of
treatment for contusion
vs. piercing injury
http://invivotherapeutics.com/pdf/InVivo_Investor_Presentation_3.14.13.pdf
Drug Releasing Polymer
Technology
• Scaffold implanted
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http://physrev.physiology.org/content/87/1/315/F7.expansion.html
with peroxynitrite
scavenger
Reduces
neuroinflammatory NO
free radicals
Addresses the issue of
secondary cell death
Procedure
http://www.invivotherapeutics.com/ourresearch/
Effectiveness
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2009 primate study
Without treatment, loss of leg
function
With scaffold, animal is able
to run on a treadmill and use
its toes to grip and climb a
ladder
Greater injury recovery
Clinical Study
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Hoping to begin clinical trials
in 2013
Received HDE status from the
FDA in April 2012
5 acute SCI patients at
Brigham & Women's and
Geisinger Hospital (PA)
Rehab at Shepherd Center
(GA)
One-year followup
Cost, Complications, and
Recovery Process
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$60,000 - $100,000
Uncertainty of coverage
No current recovery
procedures for humans
Technology still in the
early developmental phase
Only known complications
thus far are those
associated with invasive
surgery
Future Developments
• 510(k) approval
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for two
neurological
devices
Expected to be on
the market for
late 2014
15 Billion
potential market
share