Download AveULTRA: All-Natural Support for Standard Cancer Therapies

AveULTRA: All-Natural Support for Standard Cancer Therapies &
Immune Health
While new research is focusing on the broader immune support potential of this special
nutrient, the major emphasis to date has been its benefit for people undergoing standard
cancer treatments - helping to improve outcomes and reduce adverse reactions.
Avemar® (fermented wheat germ extract) - the active ingredient in AveULTRA™ - is
considered part of standard therapy for cancer patients in Hungary and is classified as a
"dietary food for special medical purposes for cancer patients" in Europe. Its development
was built on the work of two Nobel Laureates, more than six decades of research, and perhaps
a small miracle.
The Story Behind the Story
In 1931, the German scientist Dr. Otto Warburg was awarded the Nobel Prize for his
discovery that cancer cells use glucose (sugar) at a rate 10 to 50 times higher than healthy
cells. It is this enormous consumption of glucose which fuels the explosive growth of cancer.
A few years later, another Nobel Prize winner - the Hungarian-born biochemist Dr. Albert
Szent-Gyorgyi (who won for his discovery of Vitamin C) - set out to discover why there
seemed to be much lower rates of cancer in populations that consumed large amounts of
whole grain products. His theory was that supplementing a natural compound found in wheat
germ could prevent cancer cells from growing without affecting healthy cells. His early
studies, published in the 1960s in the Proceedings of the National Academy of Sciences USA,
showed that, in the lab at least, his theory was correct.
Unfortunately, it was at about that time the scientific community began focusing on cancer
treatments that are cytotoxic (i.e., toxic to cells) like chemotherapy and radiation, so Dr.
Szent-Gyorgyi's theory was set aside.
The Avemar Story - A Miracle?
Under communism, Hungarian scientists were not allowed to pursue their own personal
research projects. But when communism fell in 1989, Dr. Mate Hidvegi decided to pick up
where Dr. Szent-Gyorgyi had left off. The problem with the standard cytotoxic cancer
treatments being used was that they couldn't differentiate between cancer cells and healthy
cells. So in order to kill the cancer cells, they also ended up destroying the healthy cells. He
wanted to find a way to attack the cancer cells and still protect the healthy cells.
Although Dr. Hidvegi was making good progress, his funding soon ran out and it looked like
the research would once again have to be set aside. His wife was pressuring him to give up
research and find a job that paid. But Dr. Hidvegi was a man with a great deal of faith. He
prayed to the Virgin Mary for both guidance and an investor. The very next day a stranger
gave him a large check – in the $100,000 ballpark – enabling him to continue his research and
finally patent his technique of fermenting wheat germ with brewer's yeast. Dr. Hidvegi named
the resulting product Avemar as a tribute to the Virgin Mary ("Ave" means "hail" and "Mar"
means "Mary").
The Science Supporting Avemar
Avemar has been the subject of more than 100 studies – in laboratory cell lines, with animals,
and in human clinical trials – and its research has been published in more than 30 articles in
respected medical peer-reviewed journals. While there is some research on the use of Avemar
for autoimmune diseases like rheumatoid arthritis and lupus, the vast majority of research has
focused on its effect as a support for people undergoing various types of cancer treatment.
Some examples:

In a controlled study of 170 patients with primary colorectal cancer, half received
"standard of care" (surgery, radiation, chemotherapy and/or other appropriate
therapies) and half received "standard of care" plus once-a-day Avemar. Only 3
percent of the Avemar group experienced a recurrence of the cancer, as opposed to 17
percent of the standard-care-only group. In addition, there was a 67 percent reduction
in metastasis and a 62 percent reduction in deaths in the Avemar group.(1)

A one-year, non-randomized trial of oral cancer patients(2) showed some impressive
results:
Treatment / No. of
Patients
Local Recurrence (recurred
in same spot)
Disease Progression (metastasis
and/or death)
Standard care / 21
57.1%
61.9%
Standard care +
Avemar / 22
4.5%
9.09%

In a randomized study of stage III melanoma patients, 26 received surgery and
chemotherapy and 26 received the same with the addition of Avemar taken once a day.
Those in the Avemar group had nearly a 50% reduction in risk of progression. The
researchers concluded: "We, therefore, highly recommend the inclusion of this
fermented wheat-germ-extract-based medical nutriment into the adjuvant protocols of
high-risk skin melanoma patients."(3)
Many of the studies also observed that the use of Avemar with standard cancer treatments was
associated with reduced frequency and severity of some of the side effects commonly
experienced with chemotherapy and radiation, such as nausea, fatigue, weight loss and
immune suppression.
How Avemar Works
In 2005, researchers at UCLA published a review of multiple studies done on Avemar and
outlined some of the biological mechanisms involved in Avemar's apparent ability to help the
body cope with cancer.(4) This review of in vitro and in vivo research demonstrated how
Avemar:
1. Blocks glucose uptake in cancer cells, cutting off their energy supply.
Cancer cells crave glucose. It's what allows them to thrive and grow. The higher the rate of
glucose utilization a cancer cell has, the greater its chance of spreading. A 2001 study showed
not only that Avemar significantly reduced glucose utilization in a broad range of different
types of cancer cells, but also that the worse the malignancy was, the more Avemar inhibited
the cells’ glucose utilization.(5) When cancer cells are no longer able to utilize glucose, they
can no longer continue to grow.
2. Promotes cancer cell death by apoptosis (programmed cell death).
Cancer cells tend to reproduce so quickly and chaotically that they end up having a lot of
breaks in their cellular structures. Because of this, cancer cells need a lot of the enzyme PARP
(poly-ADP-ribose) in order to repair the breaks. When there is no PARP available, another
enzyme called Caspase-3 steps in and sets up a programmed cell death. In a study of leukemia
tumor cells, researchers demonstrated that Avemar inhibited the production of PARP and
increased the production of Caspase-3, which helped promote the programmed death of the
cancer cells.(6)
3. Unmasks cancer cells working in disguise.
Healthy cells have a membrane feature called MHC-1 (Major Histocompatibility Complex 1)
that basically tells natural killer (NK) cells - the immune system's first line of defense - "I'm a
good guy; don't attack me." Cells that have been infected with a virus don't have that
membrane, which readily identifies them as a target for the NK cells. But some cancer cells
have learned how to work in disguise, displaying the MHC-1 membrane, which effectively
hides them from the NK cells. Avemar helps the immune system find those cancer cells by
suppressing their ability to disguise themselves.(7)
Not Just for Cancer Patients
Although most of the focus in the development and testing of Avemar has centered around
support of cancer patients, there is significant evidence that Avemar promotes an overall
healthy immune system. Early research on the use of Avemar as a supplement to standard
care for autoimmune diseases has yielded positive results. Scientists are continuing to explore
the possibilities of how Avemar may be used to support the immune system. And in fact Rich
Carson, ProHealth's founder, considers AveULTRA a fundamental part of his personal
protocol to fight ME/CFS.
"As Safe as Whole Wheat Bread"
Unlike standard cancer treatments, which are highly toxic, Avemar was found not to be toxic
at all. In fact, a safety study published in the International Journal of Toxicology found that
taking Avemar was as safe as eating whole wheat bread.(8) In the United States, this extract
has fulfilled the self-affirmed "generally recognized as safe" (GRAS) status.
Avemar, Ave, and AveULTRA – What's the difference?
Avemar* is fermented wheat germ extract and is the active ingredient in both Ave and
AveULTRA. Ave™ was the first dietary supplement to contain Avemar. AveULTRA is the
new and improved version of Ave.
AveULTRA is the result of Dr. Hidvegi's effort to improve his original patented, fermented
wheat germ processing method. Some of the improvements include:

Utilizing low-temperature freeze-drying, eliminating the need to add maltodextrin as a
stabilizer.

Replacing fructose sweetener with the natural, zero-calorie sweetener Stevia, Reb-A.

Making it three times more concentrated – 5.5g of AveULTRA is equal to 17g of Ave.

Reducing the non-active ingredients by 99 percent.

Improving the taste.
Important Details About the Use of AveULTRA
How to take it: AveULTRA is a mild orange-flavored instant drink mix in powder form. Add
one packet of AveULTRA to 4 oz. of cold water (or juice that has less than 10 mg of vitamin
C) in a container with a lid and shake until dissolved. Consume it within 30 minutes of
mixing.
When to take it: AveULTRA should be taken once a day, one hour before or after a meal,
and two hours before or after any drugs or other dietary supplements.
Contraindications: Do not take AveULTRA if you are pregnant or breastfeeding; if you've
had an organ or tissue transplant; if you have bleeding GI ulcers, malabsorption syndrome,
gluten sensitivities, or sensitivity to wheat germ. If you're going to have a barium X-ray
contrast exam, it is recommended that you discontinue AveULTRA for two days prior to and
resume taking it two days after the exam.
Time required for results: Often improvements in energy, appetite and daily function are
seen within three weeks. Objective markers such as blood markers, CAT scans, MRIs, etc.
typically take about three months.
Potential side effects: A few people have reported very minor GI discomfort that went
away after a few days. No vomiting, diarrhea or other GI problems have been reported.
Final Thoughts
It's important to remember that Avemar is not promoted as a stand-alone cancer "treatment,"
nor has it been studied as such. Rather, clinical trials have shown that this dietary supplement
can be an effective support to standard cancer treatment protocols, helping to improve
outcomes and reduce adverse reactions.