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Schedule for Lectures of the Summer School “Molecular Interactions at Barriers in Inflammation” Theoretical part of the summer school in Lübeck, Audimax lecture hall 4, 06/08/12 – 10/08/12 Monday, 06/08/12 Immune Response in Inflammatory Diseases Chair: Jörg Köhl Time 8:30-08:40 8:40-09:30 Speaker Jörg Köhl Jörg Köhl 9:30-10:20 10:20-10:50 10:50-11:40 Claudia Kemper Coffee Break Peter Zipfel 11:40-12:30 Norbert Reiling 12:30-14:00 14:00-14:50 Lunch Tamas Laskay 14:50-15:40 15:40-16:00 16:00-16:50 Björn Rabe Coffee Break Rudolf Manz 16:50-17:40 Marc Ehlers 17:40-18:30 All speakers, panel discussion with students: “Emerging concepts in immunoregulation of inflammation at barrier organs” Tuesday, 07/08/12 Title Introduction Complement as an immune sensor and regulator of innate and adaptive immune responses New concepts in human Th1 regulation by innate signals A lesson learned from pathogenic microbes -complement and innate immunity control homeostasis When the WNT blows.... Novel functions of an evolutionarily conserved signaling system in the regulation of inflammation Neutrophil granulocytes: The contribution of cell death to antimicrobial defense and to the resolution of inflammation IL-6 Signaling pathways The multiple roles B cells play for induction and suppression of inflammation Antibodies: subclasses, effector functions and sugars The Microbiome in Environment and Evolution Time 9:00-09:10 9:10-10:00 10:00-10:30 10:30-11:20 11:20-12:40 Speaker Thomas Bosch Thomas Roeder Coffee Break Juris Grasis John Baines 12:40-14:00 14:00-14:50 14:50-15:40 Lunch Philip Rosenstiel Hinrich Schulenburg Irina Majul Chair: Thomas Bosch Title Introduction How Drosophila epithelia control microbial communities Towards understanding the evolution of host-virus interactions Evolutionary and ecological forces shaping diversity in the intestinal microbiota 16:30-18:30 Genome-genome interactions at the intestinal barrier Experimental evolution as a tool to dissect the dynamics and genomics of host-parasite interactions Human microbiome and evolution of small GTPases and their regulators Poster Session with Coffee Break and Snack From 19:30 Public Evening Lecture with Thomas Bosch: Living in a Microbial World 15:40-16:30 Wednesday, 08/08/12 Host-Pathogen Interaction Time 8:30-08:40 8:40-09:30 9:30-10:20 10:20-10:50 10:50-11:40 11:40-12:30 Speaker Rolf Hilgenfeld Nicole Fischer Albrecht von Brunn Coffee Break Jan Rupp Thomas Peters 12:30-14:00 14:00-14:50 14:50-15:40 15:40-16:00 16:00-16:50 Lunch Norbert Tautz Guntram Graßl Coffee Break Ulrich Schaible 16:50-17:40 17:40-18:30 Stefan Ehlers Christoph Hölscher Chair: Lars Redecke Title Introduction Virus hunting using array and sequencing technologies Applying systems biology to virus-host interactions Imaging of host-pathogen metabolic activities in living cells Identification and characterization of virus-receptor interactions using NMR experiments Deregulation of viral replication in lethal mucosal disease? How Salmonella breaches the barrier and causes disease The cell biology of intracellular bacterial infections with a focus in tuberculosis The granuloma in tuberculosis: a host-pathogen collusion Alternatively activated macrophages: the exit route for tubercle bacilli? Thursday, 09/08/12 Lipidomic-Sphingolipid Signaling in Health and Disease Time 8:30-08:40 8:40-09:30 9:30-10:20 Speaker Ulrich Schaible Monica Palmada Kathleen Reiss 10:20-10:50 10:50-11:40 Coffee Break Dieter Adam 11:40-12:30 Stefan Schütze 12:30-14:00 14:00-14:50 14:50-15:40 15:40-16:00 16:00-16:50 Lunch Martin Krause Otto Holst Coffee Break Konrad Sandhoff From 17:00 Barbecue and get together with all speakers Chair: Ulrich Schaible Title Introduction Sphingolipid involvement in infectious diseases The role of acid sphingomyelinase in sepsis and acute respiratory failure Regulation of necroptosis and lysosome size via acid and neutral sphingomyelinase Compartmentalization of ceramide production in tumor necrosis factor receptor-1 signaling Airway epithelial injury in mechanical ventilation Structure and function of certain bacterial glycolipids Sphingolipid catabolism and the lipid phase problem Friday, 10/08/12 Molecular Processes in Inflammation and Infection Time 8:30-08:40 8:40-09:30 9:30-10:20 10:20-10:50 10:50-11:40 11:40-12:30 Speaker Andreas Tholey Andreas Tholey Rolf Hilgenfeld Coffee Break Thomas Gutsmann Buko Lindner 12:30-14:00 14:00-14:50 14:50-15:40 15:40-16:00 Lunch Ulrich Zähringer Peter König Andreas Tholey Chair: Andreas Tholey Title Introduction Proteomics in host-pathogen interactions Structural systems biology of virus-host interactions Membrane biophysics in infectious disease Lipidomics, a new analytical tool for the characterization of molecular processes in inflammation and infection Glycolipids and NMR: Friends or Foes? Multiphoton microscopy to visualize host pathogen interaction Conclusion