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Immun 441
Practice Questions Set #1
AB Discussion section
1. What is the evolutionary purpose of having both an innate and adaptive immune system
that function as they do in humans?
2. Name 3 different types of barriers (mechanical, chemical, and microbial) that protect us
from pathogens and list the key features for each category.
3. A dendritic cell phagocytoses a gram-negative bacteria. Which PAMP(s) may be
detected? Which innate immune receptor will be detecting the PAMP(s)?
4. What type of pathogens do surface TLRs recognize? Endosomal TLRs?
5. Why is it logical that the TLRs are located where they are?
6. What cellular mechanisms and gene expression programs do TLRs activate?
7. Which cells are considered to be Professional Antigen Presenting (APC) cells and what
differentiates them from ‘non-professional’ antigen presenting cells.
8. Describe the similarities and differences between the three types of programmed cell
death.
9. Give examples of pathogens that would undergo the Classical, Lectin, and Alternative
pathways.
10. Name 3 forms of regulation within the complement cascade.