Download Nociceptin mediated microvascular inflammation during sepsis

The University of Sheffield
Faculty of Medicine, Dentistry & Health
Department of Infection & Immunity
Mediators of Histidine Phosphorylation in Innate Immunity.
Supervisor: Dr Richmond Muimo
Project:Reversible
phosphorylation
of
the
histidine
amino
acid
residue
is
increasingly recognised as a key phosphorylation event. Proteins containing
phosphohistidine (pHis) are implicated in various mammalian cellular processes
including regulation of ion channels, apoptosis, cell proliferation and differentiation,
inflammation, chromatin biology, cancer and cell signalling. However, much remains
to be understood about the role and extent of the modification in mammalian cell
biology. The study of both the extent and functional role of pHis in signaling, either
in vitro or in vivo, is complicated by the instability of the pHis modification. As a
consequence, we are currently handicapped by a chronic lack of chemical and
biochemical tools with which to study histidine phosphorylation. The aim of this
project is to develop tools for the study of the role of histidine phosphorylation in
mammalian cells. We will incorporate novel stable analogues of phosphohistidine
that we have recently synthesized into relevant peptide sequence to develop potent
and specific reagents as protein-protein interaction and PHP inhibitors.
Entry Requirements:
Candidates must have a first or upper second class honors degree or significant
research experience.
Enquiries:
Interested candidates should in the first instance contact Ricmond Muimo,
[email protected]
How to apply:
Please complete a University Postgraduate Research Application form and attach at
least two references to your application. To complete the application form please
visit: www.shef.ac.uk/postgraduate/research/apply.
Please clearly state the prospective main supervisor in the respective box and select
‘Infection & Immunity’ as the department.
Closing date: Open