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Transcript
Nutrients that Support Phase II Detoxification Pathways During phase II detoxification, activated substances from phase I, which are known as intermediates are conjugated and altered further before expulsion from the body. Six different major biochemical reactions occur in this phase, known as: Glutathione conjugation Amino acid conjugation Methylation Sulfation Acetylation Glucuronidation Each of these reactions works on specific types of intermediates and needs specific nutrients in order to proceed to successful completion. The nutrients required for phase II fall into two categories. The first are the amino acids, which donate molecules that are attached to phase I intermediates. These include the sulfur donors, among which are the amino acids methionine, taurine, cysteine, and Nacetylcysteine. Other, non-sulfur-containing amino acids are also required: glycine, taurine, glutamine, ornithine, and arginine. Table: Nutrients needed by Phase II Detoxification Enzymes Nutrients Phase II Phase II System Nutrient Glutathione conjugation Glutathione Vitamin B6 Glutathione Precursors (Cysteine, Glycine, NAC) Essential Fatty Acids Vitamin B6 Amino acid conjugation Glycine Folic Acid, Manganese, B-2, B-6/P-5-P Taurine Glutamine Arginine Ornithine Methylation S-adenosyl-methionine (SAMe) Magnesium Folic Acid Vitamin B12 Betaine (TMG) Sulfation Cysteine Methionine Molybdenum Vitamin B12 Folic Acid Magnesium MSM Taurine Acetylation Acetyl CoA Molybdenum Iron Niacinamide (B3) Vitamin B2 Glucuronidation Glucuronic acid Magnesium B-Vitamins Print This Post Related Posts Support and Enhancement of Phase II Detoxification Pathways Using Foods, Food-Derived Components and Nutrients Maximizing The Sulforaphane Content of Broccoli and Broccoli Sprouts Rice Bran Fiber found to bind effectively to toxic Polychlorinated Biphenyls (PCBs) more than other tested natural substances Freezing Broccoli Sprouts Increases Sulforaphane Yield Increasing Nrf2: A Master Regulator of the Aging Process
