Download Scientist, Molecular Interaction and Characterization

Date: 03/24/17
Scientist, Molecular Interaction and Characterization BioAnalytical Sciences (BAS)
Job ID: 3400077622
Job Function
Other Development
Schedule
Full-time
Location
United States - California
South San Francisco
Job type
Company/Division
Job Level
Pharmaceuticals
Individual Contributor
Regular Employee
The Position
The BioAnalytical Sciences (BAS) Department within Development Sciences develops,
validates, implements, and maintains biological matrix assays and automated systems in
both non-regulated and compliant environments to support clinical and nonclinical studies.
The Core Biophysical Characterization and Reagent Facility (CBCRF) in BAS provides
critical molecular interaction information and well characterized bioanalytical assay reagents
to enable biopharmaceutical development at Genentech.
A Scientist in the CBCRF group is a highly motivated and creative individual who designs,
develops and refines in vitro methodologies to characterize both biotherapeutics and
bioanalytical reagents in support of regulatory filings. This individual will develop molecular
interaction strategies, will evaluate and implement a range of biophysical methods to
characterize protein-target interactions and bioanalytical reagents, will present strategies and
datasets to project teams and scientific review committees. S/he will manage timelines and
resources to meet project and functional goals.
The Scientist will also develop and characterize in vitro assay methods for biological
characterization of biotherapeutics and bioanalytical assay reagents. This will involve
laboratory work, the use of automation systems and various biophysical and biochemical
platforms, and participation in compliance and safety related activities. This individual will
also take on the responsibility of establishing subject matter expertise within Development
Sciences in the area of molecular interaction analysis and reagent characterization. They
may work with external expertise and internal colleagues to help design and execute
molecular interaction strategies for pre-clinical and clinical studies.
This individual may be responsible for writing technical reports and/or sections of regulatory
filings related to bioanalytical assay reagents and/or characterization of biological activity.
This individual may also be involved with the assessment and implementation of new
technologies, reagents, and methods. This Scientist will work in a very fast-paced crossfunctional environment, and is expected to contribute to departmental activities. This
individual may also be expected to help train colleagues and to mentor and/or supervise
more junior colleagues.
Who You Are
A Ph.D. in Biochemistry, Biophysics, Chemistry, Immunology, or a related field or an
equivalent credential is required, with at least two years of relevant postgraduate experience.
Background knowledge and practical experience in developing bioanalytical methods and
reagents for protein therapeutics, along with a proven track record of productivity and
publications solving complex bioanalytical problems are essential. A strong technical
background that includes extensive laboratory experience in molecular interaction work (e.g.,
thermodynamics, kinetics, binding affinity measurement using surface plasmon resonance) is
essential. Proficiency in biophysical characterization methods such as light scattering, HPLC
for biologics would be a plus. Familiarity with standard text, graphic, and presentation
software is required, and familiarity with database/data archival software systems is helpful.
Excellent communication, interpersonal and organizational skills are required.
Pharmaceutical or biotechnology industry experience is a real advantage, as is a basic
understanding of compliance.
*LI-gRED-EK
Who We Are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology
industry for more than 40 years, using human genetic information to develop novel
medicines for serious and life-threatening diseases. Genentech has multiple therapies on the
market for cancer & other serious illnesses. Please take this opportunity to learn about
Genentech where we believe that our employees are our most important asset & are
dedicated to remaining a great place to work.
Genentech is an equal opportunity employer & prohibits unlawful discrimination based on
race, color, religion, gender, sexual orientation, gender identity/expression, national
origin/ancestry, age, disability, marital & veteran status. For more information about equal
employment opportunity, visit our Genentech Careers page.